Robyn L Ball, Molly A Bogue, Hongping Liang, Anuj Srivastava, David G Ashbrook, Anna Lamoureux, Matthew W Gerring, Alexander S Hatoum, Matthew J Kim, Hao He, Jake Emerson, Alexander K Berger, David O Walton, Keith Sheppard, Baha El Kassaby, Francisco Castellanos, Govindarajan Kunde-Ramamoorthy, Lu Lu, John Bluis, Sejal Desai, Beth A Sundberg, Gary Peltz, Zhuoqing Fang, Gary A Churchill, Robert W Williams, Arpana Agrawal, Carol J Bult, Vivek M Philip, Elissa J Chesler
Hundreds of inbred mouse strains and intercross populations have been used to characterize the function of genetic variants that contribute to disease. Thousands of disease-relevant traits have been characterized in mice and made publicly available. New strains and populations including consomics, the collaborative cross, expanded BXD, and inbred wild-derived strains add to existing complex disease mouse models, mapping populations, and sensitized backgrounds for engineered mutations. The genome sequences of inbred strains, along with dense genotypes from others, enable integrated analysis of trait-variant associations across populations, but these analyses are hampered by the sparsity of genotypes available...
January 30, 2024: Genome Research