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Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association

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https://www.readbyqxmd.com/read/27976643/gluten-free-hepatomiracle-in-celiac-hepatitis-a-case-highlighting-the-rare-occurrence-of-nutrition-induced-near-total-reversal-of-advanced-steatohepatitis-and-cirrhosis
#1
Kavita Gaur, Puja Sakhuja, Amarender S Puri, Kaushik Majumdar
Regression of hepatic fibrosis is increasingly becoming a reality, both in clinical as well as experimental models. Reversal or near-total regression of marked liver steatohepatitis and fibrosis, however, remains a rare event. We report the case of a 20-year-old female presenting with diarrhea due to celiac disease and biopsy proven cirrhosis with portal hypertension who had a remarkable clinical improvement in response to a gluten free diet (GFD). A follow-up liver biopsy 9 months after the initiation of GFD revealed a remarkable regression of both fibrosis as well as steatosis...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976642/solitary-rectal-ulcer-syndrome-a-single-center-case-series
#2
Abdulaziz I AlGhulayqah, Ehab H Abu-Farhaneh, Fahad I AlSohaibani, Majid A Almadi, Hadeel M AlMana
BACKGROUND/AIM: Solitary rectal ulcer syndrome (SRUS) is a benign, chronic defecation disorder with varied presentations. The aim of this study is to summarize the clinical features, endoscopic findings, histological appearance, and treatment strategies associated with SRUS. PATIENTS AND METHODS: This is a retrospective study of all patients diagnosed with SRUS at the King Faisal Specialist Hospital and Research Centre in Riyadh from January 2003 to December 2013...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976641/deoxyschizandrin-suppresses-dss-induced-ulcerative-colitis-in-mice
#3
Wen-Feng Zhang, Yan Yang, Xin Su, Da-Yan Xu, Yu-Li Yan, Qiao Gao, Ming-Hua Duan
BACKGROUND/AIMS: Deoxyschizandrin as one of the most important component of Schisandra chinensis (Turcz.) Baill plays an immunomodulatory role in a variety of diseases, yet its role in ulcerative colitis remains to be elucidated. We aimed to investigate the role of deoxyschizandrin in DSS-induced ulcerative colitis in mice. PATIENTS AND METHODS: In the present study, an inflammation model of cells was constructed to confirm the anti-inflammatory effect of deoxyschizandrin...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976640/cardiac-functions-assessment-in-children-with-celiac-disease-and-its-correlation-with-the-degree-of-mucosal-injury-doppler-tissue-imaging-study
#4
Abeer Fathy, Hany M Abo-Haded, Najat Al-Ahmadi, Marwa M El-Sonbaty
BACKGROUND/AIMS: Celiac disease (CD)-associated cardiologic disorders is a growing concern. However, data regarding cardiac affection in children with CD are few. This study aimed at assessing the subclinical impact of CD on the global myocardial performance in Saudi children with CD using Doppler tissue imaging (DTI). PATIENTS AND METHODS: Conventional two-dimensional echocardiography was performed among 20 Saudi children with CDas well as 20 age and sex-matched healthy controls...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976639/p16-protein-is-upregulated-in-a-stepwise-fashion-in-colorectal-adenoma-and-colorectal-carcinoma
#5
Mahmoud Al-Ahwal, Wafaey Gomaa, Eman Emam, Yousif Qari, Abdelbaset Buhmeida, Salman Radwi, Basim Al-Maghrabi, Mohammad Al-Qahtani, Jaudah Al-Maghrabi
BACKGROUND/AIMS: p16 is tumor suppressor gene acting as a cell cycle regulator. The present study was conducted to compare p16 expression in normal, dysplastic, and malignant colonic mucosae, and to explore its relation to clinicopathological variables and follow-up data in colorectal carcinoma (CRC). PATIENTS AND METHODS: Tissue microarrays were performed from 25 normal colonic mucosae, 41 colonic adenomas, and 191 CRC, with corresponding 50 nodal metastases. Immunohistochemistry was performed using anti-p16 antibody, sections were scored, and statistical analysis was performed...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976638/effect-of-angiotensin-converting-enzyme-inhibitor-lisinopril-on-morphological-and-biochemical-aspects-of-fibrotic-liver-regeneration
#6
Aysha Ambreen, Sarwat Jahan, Satwat Malik
BACKGROUND/AIMS: Hepatic fibrosis results in defective liver regeneration following partial hepatectomy. Angiotensin converting enzyme (ACE) inhibitors can enhance liver regeneration and are also involved in the reduction of hepatic fibrosis. The present study has been conducted to evaluate the potential effect of an ACE inhibitor, lisinopril, on the morphological and biochemical aspects of fibrotic liver regeneration. MATERIALS AND METHODS: Eight-week old female Sprague Dawley rats were made fibrotic by intragastric carbon tetrachloride treatment...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976637/thromboembolic-events-in-patients-with-inflammatory-bowel-disease
#7
Farjah H Algahtani, Youssef M K Farag, Abdulrahman M Aljebreen, Nahla A Alazzam, Aamer S Aleem, Fouad F Jabri, Mohammad H Rajab, Mohamed M Shoukri
BACKGROUND/AIMS: Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity. PATIENTS AND METHODS: Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976636/intraperitoneal-administration-of-apigenin-in-liver-ischemia-reperfusion-injury-protective-effects
#8
Alexandra K Tsaroucha, Anastasia Tsiaousidou, Nikolaos Ouzounidis, Evanthia Tsalkidou, Maria Lambropoulou, Dimitrios Giakoustidis, Ekaterini Chatzaki, Constantinos Simopoulos
BACKGROUND/AIMS: Hepatic injury caused by ischemia/reperfusion (I/R) is a clinical problem associated with major liver surgery. Among other flavonoids, apigenin has shown a promising effect on I/R cases. In this study, we have investigated the effects of apigenin after liver I/R injury in rats. MATERIALS AND METHODS: Forty eight rats were randomized into the following eight groups: (1) Control-sham group: rats subjected to the surgical procedure, except for liver I/R; (2) DMSO group: rats subjected to surgery, except for liver I/R given the apigenin solvent dimethyl-sulfoxide intraperitoneally; (3) C60 group; (4) C120 group; (5) C240 group: rats underwent liver ischemia for 45 min followed by reperfusion for 60 min, 120 min, and 240 min; (6) AP60 group; (7) AP120 group; (8) AP240 group: rats underwent liver ischemia for 45 min, and then given apigenin (5 mg) intraperitoneally followed by reperfusion for 60 min, 120 min, and 240 min...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976635/outcome-of-phlebotomy-for-treating-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#9
Veeravich Jaruvongvanich, Tanawan Riangwiwat, Anawin Sanguankeo, Sikarin Upala
BACKGROUND/AIMS: No medications have been approved for managing nonalcoholic fatty liver disease (NAFLD). Lifestyle intervention is the mainstay for its treatment. Hyperferritinemia, which appears to be associated with the severity of liver injury and insulin resistance, is frequently observed in patients with NAFLD. PATIENTS AND METHODS: We conducted a systematic review and meta-analysis of the outcomes of four interventional trials regarding the effect of phlebotomy in patients with NAFLD versus the outcomes of NAFLD patients who did not undergo phlebotomy...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976634/partial-splenic-embolization-has-beneficial-effects-for-the-management-of-gastroesophageal-variceal-hemorrhage
#10
Ping Wang, Ruibo Liu, Liquan Tong, Yangjing Zhang, Tongyun Yue, Haiquan Qiao, Feng Zhang, Xueying Sun
BACKGROUND/AIMS: Partial splenic embolization (PSE) is used in the management of gastroesophageal variceal hemorrhage (GEVH). However, it is uncertain whether it has beneficial effects for GEVH patients in preventing variceal recurrence and variceal hemorrhage, as well as promoting overall survival (OS), when it is combined with conventional therapies. MATERIALS AND METHODS: The databases including PubMed, EMBASE, Web of Science, Google scholar, and Cochrane Central Register of Controlled Trials were searched up to 11th of November, 2015...
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27976633/partial-splenic-embolization-for-gastroesophageal-variceal-bleeding-a-potential-long-waiting-to-be-tapped
#11
EDITORIAL
Hemant Sharma, Ibrahim Al Hasan, Bandar Al-Judabi
No abstract text is available yet for this article.
November 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748328/impact-of-pediatric-inflammatory-bowel-disease-on-linear-growth-data-from-a-national-cohort-study-in-saudi-arabia
#12
Mohammad I El Mouzan
No abstract text is available yet for this article.
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748327/pediatric-gastrointestinal-sarcoidosis-successful-treatment-with-infliximab
#13
Laila Alawdah, Ahmad Nahari, Dayel Alshahrani, Musa Fagih, Shahid Ghazi, Abdulrahman Al-Hussaini
Gastrointestinal sarcoidosis is a rare disease with very limited data in children. Here we report the first pediatric case of successful treatment with infliximab. The first case was an 8-year-old Saudi girl who presented with fever, weight loss, and abdominal pain that was followed in a few months with hematemesis and development of hepatosplenomegaly. The second case was a 9-year-old Sudanese boy who manifested with vomiting, epigastric pain, and weight loss. On upper endoscopy, both cases demonstrated severe erosive nodular gastric mucosa...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748326/efficacy-of-repeat-review-with-flexible-spectral-imaging-color-enhancement-in-patients-with-no-findings-by-capsule-endoscopy
#14
Yuka Minami-Kobayashi, Atsuo Yamada, Hirotsugu Watabe, Hirobumi Suzuki, Yoshihiro Hirata, Yutaka Yamaji, Haruhiko Yoshida, Kazuhiko Koike
BACKGROUND/AIM: The efficacy of flexible spectral imaging color enhancement (FICE) ch. 1 (F1) for the detection of ulcerative lesions and angioectasias in the small intestine with capsule endoscopy (CE) has been reported. In the present study, we evaluated whether F1 could detect incremental findings in patients with no findings in a standard review mode. PATIENTS AND METHODS: In total, 52 patients (age: 60.1 ± 15.3 years; 30 males) with obscure gastrointestinal bleeding (OGIB) who underwent CE and in whom no lesion was detected in the small intestine in the standard mode (first review) were enrolled...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748325/endoscopic-color-doppler-ultrasonography-in-predicting-the-safety-of-endoscopic-submucosal-dissection-for-antral-heterotopic-pancreas
#15
Ling Xin, Li Qian Jun, Xu Li Hua, Zhu Hong, Chen Tian Bao, Tang Jin Hai
BACKGROUND/AIMS: Complications are important determining factors for safety of endoscopic submucosal dissection (ESD) for gastric heterotopic pancreas (HP). This study investigated whether endoscopic color Doppler ultrasonography (ECDUS) could be used to predict the feasibility, efficacy, and safety of ESD. PATIENTS AND METHODS: The study included 52 patients with heterotopic pancreas of the gastric antrum who underwent ECDUS before ESD. ECDUS was used to evaluate the submucosal vascular structure and the location of HP in gastric wall...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748324/pigment-epithelium-derived-factor-and-matrix-metalloproteinase-9-in-liver-cirrhosis
#16
Joanna Kozlowska, Tomasz Mikula, Magdalena Suchacz, Joanna Jabnonska, Wojciech Stanczak, Janusz Cianciara, Alicja Wiercinska-Drapalo
BACKGROUND/AIM: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). RESULTS: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748323/colorectal-cancer-liver-metastasis-trends-in-the-kingdom-of-saudi-arabia
#17
Mazen Hassanain, Faisal Al-Alem, Eve Simoneau, Thamer A Traiki, Faisal Alsaif, Abdulsalam Alsharabi, Heba Al-Faris, Khalid Al-Saleh
BACKGROUND/AIM: To elucidate colorectal cancer (CRC) disease patterns, demographics, characteristics, stage at presentation, metastases, and survival rates of patients, particularly those with liver metastases, at our center as the first report from the Kingdom of Saudi Arabia. PATIENTS AND METHODS: We performed a retrospective, single-center database study based on the histological diagnosis of CRC in patients seen at the King Khalid University Hospital between 2007 and 2011...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748322/inefficacy-of-triple-therapy-and-comparison-of-two-different-bismuth-containing-quadruple-regimens-as-a-firstline-treatment-option-for-helicobacter-pylori
#18
Murat Kekilli, Ibrahim K Onal, Serkan Ocal, Zeynal Dogan, Alpaslan Tanoglu
BACKGROUND/AIM: Increasing resistance of Helicobacter pylori to antimicrobials necessitated the development of new regimens and the modification of existing regimens. The present study aimed to compare the efficacy of two bismuth-containing quadruple regimens-one including clarithromycin (C) instead of metronidazole (M) and triple therapy. PATIENTS AND METHODS: Patients with H. pylori infection given the following regimens were sequentially enrolled in this retrospective study: (1) Triple therapy: Lansoprazole 30 mg b...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748321/paired-comparison-of-procedural-sequence-in-same-day-bidirectional-endoscopy-with-moderate-sedation-and-carbon-dioxide-insufflation-a-prospective-observational-study
#19
Jui-Hsiang Tang, Chi-Liang Cheng, Yen-Lin Kuo, Yi-Ning Tsui
BACKGROUND/AIMS: Same-day bidirectional endoscopy (BDE) is a commonly performed procedure, but the optimal sequence of the procedure with carbon dioxide insufflation is not well established. In this study, we investigated the optimal sequence for same-day BDE without polypectomy under moderate sedation and carbon dioxide insufflation in terms of sedation doses and colonoscopy performance. PATIENTS AND METHODS: We performed a prospective observational study of 63 asymptomatic patients who were admitted for physical check-ups...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27748320/a-systematic-review-on-the-safety-and-effectiveness-of-yttrium-90-radioembolization-for-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis
#20
Zhongzhi Jia, Guomin Jiang, Feng Tian, Chunfu Zhu, Xihu Qin
BACKGROUND/AIM: Over the past two decades, several advances have been made in the management of patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT). Yttrium-90 ( 90 Y) radioembolization has recently been made a treatment option for patients with HCC and PVTT. However, there is still a need to systematicly evaluate the outcomes of 90 Y radioembolization for HCC and PVTT. We aimed to assess the safety and effectiveness of 90 Y radioembolization for HCC and PVTT...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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