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Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association

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https://www.readbyqxmd.com/read/29205188/validity-and-clinical-impact-of-glucose-transporter-1-expression-in-colorectal-cancer
#1
Ghada M K GabAllah, Mona Salah El-Din Habib, Shimaa El-Shafey Soliman, Zienab A Kasemy, Suzy F Gohar
BACKGROUND/AIM: There is no doubt that colorectal cancer (CRC) poses a major threat to public health worldwide, and despite improvement in managements, prognosis still remains an irritating question with no definite answer. Being a fundamental player in cancer metabolism, glucose transporter 1 (GLUT1) could be utilized as a prognostic biomarker that could fuel development of new treatment strategies. The aim of this study was to assess the validity of GLUT1 expression as a prognostic biomarker and to elucidate to what extent it is immersed in poor clinical outcome among CRC patients...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205187/a-ct-guided-fat-transversing-coaxial-biopsy-technique-for-pancreatic-lesion-biopsy-that-avoids-major-organs-and-vessels
#2
Chia-Ying Lin, Ming-Ching Ou, Yi-Sheng Liu, Ming-Tsung Chuang, Yan-Shen Shan, Hong-Ming Tsai, Chien-Kuo Wang, Yi-Shan Tsai
BACKGROUND/AIMS: The purpose of this study is to report our results using a computed tomography (CT)-guided fat transversing coaxial biopsy technique for pancreatic lesion biopsy that avoids major organs and vessels. We retrospectively reviewed the records of patients referred to our department for pancreatic mass biopsy. PATIENTS AND METHODS: The records of patients (from June 2008 to August 2014) in whom biopsy was performed under CT guidance with a coaxial needle using a fat transversing technique were reviewed...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205186/a-cross-sectional-survey-of-multi-generation-inflammatory-bowel-disease-consanguinity-and-its-relationship-with-disease-onset
#3
Mahmoud Mosli, Abdulelah Alzahrani, Showlag Showlag, Abdullah Alshehri, Ahmed Hejazi, Majed Alnefaie, Adel Almaymuni, Mubarak Abdullahi, Mohammed Albeshir, Eman Alsulais, Hani Jawa, Emad Aljahdli, Salem Bazarah, Yousif Qari
Background\Aim: Consanguinity influences the phenotypic variations of some hereditary and immune-mediated disorders, including inflammatory bowel disease. This study estimated the prevalence of consanguinity among the ancestors of patients with inflammatory bowel disease and examined the effect of various consanguinity levels on inflammatory bowel disease onset. PATIENTS AND METHODS: Patients with inflammatory bowel disease who were seen at two gastroenterology outpatient clinics were consecutively recruited and surveyed for demographics, disease onset, and presence of ancestral consanguinity within three generations...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205185/knowledge-attitude-and-practices-of-primary-health-care-physicians-toward-colorectal-cancer-screening
#4
Mahmoud Mosli, Yaser Alnahdi, Abdusalam Alghamdi, Mohammad Baabdullah, Afnan Hadadi, Khaleel Khateery, Ibrahim Alsulami, Abdulaziz AlHoqail, Majid Almadi, Hani Jawa, Emad Aljahdli, Salem Bazarah, Yousif Qari
BACKGROUND/AIM: Early diagnosis of chronic illnesses and cancers mainly occurs at primary health care centers (PHCs) by primary health care physicians (PHPs). The incidence of colorectal cancer (CRC) in the Kingdom of Saudi Arabia (KSA) is rising and this has been attributed to many factors. The increasing incidence of CRC is compounded by nonadherence to screening recommendations. Therefore, evaluating PHPs knowledge, attitudes, and practices of screening for CRC is clinically important...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205184/adipose-derived-mesenchymal-stem-cells-suppress-of-acute-rejection-in-small-bowel-transplantation
#5
Yu Zhang, Qinghong Meng, Yanyan Zhang, Xiaobo Chen, Yuliang Wang
BACKGROUND/AIMS: Adipose-derived mesenchymal stem cells (ADSCs) possess immunosuppressive activity and hold promise in autologous cell-based therapies. The aim of this study was to determine whether autologous ADSCs can improve outcomes in the rat small bowel transplantation (SBT) model. MATERIALS AND METHODS: Allogeneic SBT followed by implantation of autologous ADSCs through the penile vein was conducted in Brown-Norway (BN) donor rats with Lewis (LEW) recipient rats infused with phosphate buffered solution as the control...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205183/feasibility-of-conversion-of-percutaneous-cholecystostomy-to-internal-transmural-endoscopic-ultrasound-guided-gallbladder-drainage
#6
Tanyaporn Chantarojanasiri, Saburo Matsubara, Hiroyuki Isayama, Yousuke Nakai, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Ryunosuke Hakuta, Yukiko Ito, Minoru Tada, Kazuhiko Koike
BACKGROUND/AIM: Percutaneous cholecystostomy [percutaneous transhepatic gallbladder drainage (PTGBD)] is the treatment of choice in surgically unfit patients with acute cholecystitis. However, PTGBD tube removal after symptoms resolution results in 41-46% recurrence. This study aims to demonstrate the feasibility of the conversion of PTGBD to transmural endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using plastic stents in patients unfit for cholecystectomy. PATIENTS AND METHODS: Patients who underwent internal transmural EUS-GBD as a conversion from PTGBD were reviewed...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205182/association-between-gastroesophageal-reflux-disease-and-nonalcoholic-fatty-liver-disease-a-meta-analysis
#7
REVIEW
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Charat Thongprayoon, Veeravich Jaruvongvanich, Patompong Ungprasert
BACKGROUND/AIM: The relationship between gastroesophageal reflux disease (GERD) and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in recent epidemiologic studies although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of NAFLD among patients with GERD. MATERIALS AND METHODS: Comprehensive literature review was conducted using MEDLINE and EMBASE database from inception through November 2016, to identify studies that compared the risk of NAFLD among patients with GERD versus those without GERD...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29205181/feasibility-of-the-conversion-of-percutaneous-cholecystostomy-to-internal-transmural-endoscopic-ultrasound-guided-gallbladder-drainage
#8
EDITORIAL
Anthony Y B Teoh
No abstract text is available yet for this article.
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937028/a-rare-etiology-of-idiopathic-acute-pancreatitis
#9
LETTER
Malay Sharma, Piyush Somani
No abstract text is available yet for this article.
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937027/ascariasis-and-pancreatitis
#10
LETTER
Vipul D Yagnik
No abstract text is available yet for this article.
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937026/intrahepatic-cholestasis-in-two-omani-siblings-associated-with-a-novel-homozygous-atp8b1-mutation-c-379c-g-p-l127v
#11
Hassib Narchi, Suhailah Alhefeiti, Fatmah Althabahi, Jozef Hertecant, A S Knisely, Abdul-Kader Souid
We report two Omani brothers with intrahepatic cholestasis that resolved with supportive care. In one, cholestasis began in infancy; in the other, only at the age of 18 months. Whole exome sequencing identified a novel homozygous variant, c.379C>G (p.L127V) in ATP8B1. Those attending patients with cholestasis from the Arabian peninsula should be aware of this mutation and of the variation in its phenotypic effects.
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937025/the-efficacy-and-safety-of-the-left-lateral-position-for-endoscopic-retrograde-cholangiopancreatography
#12
Tae Young Park, Sang Hyeon Choi, Young Joo Yang, Suk Pyo Shin, Chang Seok Bang, Ki Tae Suk, Gwang Ho Baik, Dong Joon Kim
BACKGROUND/AIM: Endoscopic retrograde cholangiopancreatography (ERCP) is typically performed in prone position. In cases of difficulty in prone position, ERCP can be performed in left lateral position. We aimed to evaluate the efficacy and safety of left lateral position for ERCP compared with those of prone position. PATIENTS AND METHODS: Between August 2015 and March 2016, a total of 62 patients with native papilla who underwent ERCP were randomly assigned to undergo the procedure in left lateral position (n = 31) or prone position (n = 31)...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937024/celiac-disease-related-osteopathy-among-saudi-celiac-patients-are-we-adherent-to-recommendations
#13
Mona A Fouda
BACKGROUND/AIMS: There are no reports from Saudi Arabia documenting the picture of osteopathy in celiac disease (CD) and the adherence of physicians to the guidelines and recommendations to screen for bone disease. We conducted this study to document the prevalence of CD-related osteopathy and the Saudi physicians' adherence to the screening recommendations. PATIENTS AND METHODS: We identified the biopsy proven CD cases diagnosed between 2003 and 2012. In addition to demographic data, we collected laboratory (serum calcium, phosphate, alkaline phosphatase, 25-dihydroxy vitamin D, and parathyroid hormone levels) and imaging [Dual-energy X-ray absorptiometry (DEXA)] data...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937023/pre-illness-diet-as-risk-factor-in-pediatric-inflammatory-bowel-disease-in-saudi-arabia
#14
Mohammad I El Mouzan, Mohammad A Al Mofarreh, Ahmad A Al Sarkhy, Asaad M Assiri, Yassin M Hamed
BACKGROUND/AIM: Inflammatory bowel disease (IBD) is increasing in Saudi Arabia but there's little knowledge about its risk factors. Our aim is to investigate the dietary risk factors of this disease in Saudi children. PATIENTS AND METHODS: The children investigated for IBD were prospectively enrolled. Those with confirmed IBD were designated cases and the others were controls. The average food frequency intake at least 3 months before onset of illness was obtained by direct interview and recorded on a modified food frequency questionnaire...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937022/yield-of-p53-expression-in-esophageal-squamous-cell-cancer-and-its-relationship-with-survival
#15
Tushar H Sankalecha, Sudhir J Gupta, Nitin R Gaikwad, Nikhil U Shirole, Harit G Kothari
BACKGROUND/AIMS: Esophageal squamous cell carcinoma (ESCC) is the most aggressive type of cancer. Mutation of tumor suppressor gene p53 is observed in many gastrointestinal malignancies including ESCC. The immunohistochemical protein expression of mutant p53 has been proposed as a potential tool to evaluate the biological behavior of ESCC. Predictive value of p53 for survival is debatable, hence this study was formulated to know the survival of patients with p53 expression in ESCC. PATIENTS AND METHODS: We prospectively included 91 consecutive patients of ESCC from August 2014 to August 2016...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937021/optimized-high-dose-amoxicillin-proton-pump-inhibitor-dual-therapies-fail-to-achieve-high-cure-rates-in-china
#16
Jia-Li Hu, Jun Yang, Yin-Bin Zhou, Ping Li, Ran Han, Dian-Chun Fang
Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylori infection. Rabeprazole dosages for H. pylori eradication were also evaluated. PATIENTS AND METHODS: Treatment-naive and H...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937020/unique-characteristics-of-arid1a-mutation-and-protein-level-in-gastric-and-colorectal-cancer-a-meta-analysis
#17
REVIEW
Young-Sik Kim, Hoiseon Jeong, Jung-Woo Choi, Hwa Eun Oh, Ju-Han Lee
BACKGROUND/AIM: Recently, AT-rich interactive domain-containing 1A protein (ARID1A) has been identified as a novel tumor suppressor gene in gastric cancer (GC) and colorectal cancer (CRC). However, the clinicopathologic value of ARID1A mutation or protein level in GC and CRC patients is controversial. Hence, we conducted a meta-analysis on the relationship between ARID1A aberrations and clinicopathologic parameters in GC and CRC. MATERIALS AND METHODS: Relevant published studies were selected from PubMed and EMBASE...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28937019/failure-of-optimized-dual-proton-pump-inhibitor-amoxicillin-therapy-what-now
#18
EDITORIAL
David Y Graham, Hong Lu, Akiko Shiotani
No abstract text is available yet for this article.
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28721982/towards-supporting-greater-and-lower-cost-access-to-direct-acting-antiviral-treatment-for-hepatitis-c-for-all-patients
#19
LETTER
Said A Al-Busafi, Heba Omar
No abstract text is available yet for this article.
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28721981/detection-of-clostridium-difficile-antigen-and-toxin-in-stool-specimens-comparison-of-the-c-difficile-quik-chek-complete-enzyme-immunoassay-and-genexpert-c-difficile-polymerase-chain-reaction-assay
#20
Abiola C Senok, Kamel M Aldosari, Rayan A Alowaisheq, Othman A Abid, Khalid A Alsuhaibani, Mohammad A Khan, Ali M Somily
BACKGROUND/AIMS: Accurate and rapid laboratory diagnosis of Clostridium difficile infections (CDI) remains a significant challenge. A two-step algorithm for detection of toxigenic C. difficile in stool based on initial screening for glutamate dehydrogenase assay followed by confirmation by toxin A+B detection using an enzyme immunoassay (EIA) or molecular assay has been proposed. We aimed to evaluate the C. difficile Quik Chek Complete® (QCC-EIA) versus the GeneXpert® C. difficile polymerase chain reaction (PCR) assay in this two-step algorithm...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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