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Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association

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https://www.readbyqxmd.com/read/30004043/biologic-agents-in-inflammatory-bowel-disease-quality-of-internet-website-information
#1
Rymon Rofaiel, Nilesh Chande
Background/Aims: Many patients currently seek the Internet for health-related information without discerning the quality or bias of the evidence presented. Biologic agents have become the mainstay of therapy in inflammatory bowel disease (IBD), and it is important that patients have access to high-quality information when exploring the various available agents to make informed decisions about their therapy. The primary aim of this study was to evaluate the quality of patient-searched Internet websites that describe the biologic agents used as treatment options for IBD...
July 6, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/30004042/real-world-single-center-experience-with-entecavir-and-tenofovir-disoproxil-fumarate-in-treatment-na%C3%A3-ve-and-experienced-patients-with-chronic-hepatitis-b
#2
Young Min Kim, Hyun Phil Shin, Joung Il Lee, Kwang Ro Joo, Jae Myung Cha, Jung Won Jeon, Jin Young Yoon, Min Seob Kwak
Background/Aim: The goal of antiviral therapy for chronic hepatitis B (CHB) is to improve survival of the patients by achieving a complete virological response (CVR). This study aimed to evaluate long-term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) in nucleos(t)ide analog (NA)-naïve and NA-experienced Korean patients with CHB and to determine the incidence of cirrhosis-related complications in these patients. Patients and Methods: We retrospectively reviewed medical records of all patients treated with ETV or TDF from July 2007 to January 2017...
July 6, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/30004041/initial-experience-of-video-capsule-endoscopy-at-a-tertiary-center-in-saudi-arabia
#3
Abdulrahman Alkhormi, Mohammed Y Memon, Ahmad Elhafi, Mishal Aljohani, Abdullah Aljahdali, Adil Khatimi, Amer Rizvi, Khaled Shaban, Ghulam Yazdani, Mohammed Alnasser
Background/Aim: No prior experience with video capsule endoscopy (VCE) has been published from Saudi Arabia. In this study, we aim to report the first Saudi experience with VCE. Patients and Methods: A prospective study was conducted between March 2013 and September 2017 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Eligible patients underwent VCE and their data (age, sex, indication for VCE, type of obscure gastrointestinal bleeding [OGIB: overt vs occult], VCE findings, and complications) were recorded...
July 6, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29956690/genetic-susceptibility-for-celiac-disease-is-highly-prevalent-in-the-saudi-population
#4
Abdulrahman Al-Hussaini, Hanan Alharthi, Awad Osman, Nezar Eltayeb-Elsheikh, Aziz Chentoufi
Background/Aim: To determine the frequency of celiac disease (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in the Saudi population, where the prevalence of CD is 1.5% as recently reported in a mass screening study. Patients and Methods: In a cross-sectional population-based study, a total of 192 randomly selected healthy school children (97 females, mean age 10.5 ± 2.2 years, all negative for tissue transglutaminase-IgA) were typed for D QA1 and D QB1 genes by polymerase chain reaction sequence-specific oligonucleotide probes...
June 29, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29956689/association-of-coagulopathy-with-the-risk-of-bleeding-after-invasive-procedures-in-liver-cirrhosis
#5
Jing Li, Bing Han, Hongyu Li, Han Deng, Nahum Méndez-Sánchez, Xiaozhong Guo, Xingshun Qi
Background/Aim: Bleeding risk among patients with acute or chronic liver disease after invasive procedures is a common concern in clinical practice. This retrospective study aimed to explore whether the presence of coagulopathy increased the risk of major bleeding after invasive procedures in cirrhosis. Patients and Methods: A total of 874 cirrhotic patients underwent invasive procedures. Coagulopathy was defined as international normalized ratio (INR) ≥1.5 and/or platelets (PLTs) ≤50 × 109 /L...
June 29, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29956688/nonalcoholic-fatty-liver-disease-burden-saudi-arabia-and-united-arab-emirates-2017-2030
#6
Khalid Alswat, Abdulrahman A Aljumah, Faisal M Sanai, Faisal Abaalkhail, Mohamed Alghamdi, Waleed K Al Hamoudi, Abdullah Al Khathlan, Huda Al Quraishi, Ahmed Al Rifai, Mohamed Al Zaabi, Mohamed A Babatin, Chris Estes, Almoutaz Hashim, Homie Razavi
Background/Aim: Due to epidemic levels of obesity and type 2 diabetes mellitus (DM), nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) will be driving factors in liver disease burden in the coming years in Saudi Arabia and United Arab Emirates (UAE). Materials and Methods: Models were used to estimate NAFLD and NASH disease progression, primarily based on changes in adult prevalence rates of adult obesity and DM. The published estimates and expert interviews were used to build and validate the model projections...
June 29, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29943736/bone-mineral-density-loss-in-patients-with-cirrhosis
#7
Ibrahim N Muhsen, Omar AlFreihi, Faisal Abaalkhail, Abdullah AlKhenizan, Mohammed Khan, Abdelmoneim Eldali, Fahad Alsohaibani
Background/Aims: Evidence of increased risk of osteoporosis and osteopenia in chronic liver disease and cirrhosis is inconsistent. This study aims to investigate this relationship and to identify the predictors of increased loss of bone mineral density in Saudi patients. Patients and Methods: One hundred and sixty-four patients and controls who are age and gender matched, were included in this study with 1:1 ratio. Patients' included in this study were adults with confirmed liver cirrhosis...
June 20, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29873320/mirizzi-s-syndrome-a-scoring-system-for-preoperative-diagnosis
#8
Rachana D Tataria, Hrishikesh P Salgaonkar, Gaurav Maheshwari, Premashish J Halder
Background/Aim: Mirizzi's syndrome (MS) is an unusual complication of gallstone disease and occurs in approximately 1% of patients with cholelithiasis. Majority of cases are not identified preoperatively, despite the availability of modern imaging techniques. A preoperative diagnosis can forewarn the operating surgeon and avoid bile duct injuries in cases of complicated cholecystitis. A preoperative scoring system helpful and hence, we aim to devise a scoring system based on clinical, biochemical, and imaging features to predict the diagnosis of MS in cases of complicated cholecystitis...
June 5, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29873319/is-water-exchange-superior-to-water-immersion-for-colonoscopy-a-systematic-review-and-meta-analysis
#9
REVIEW
Zhihao Chen, Zhengqi Li, Xinying Yu, Guiqi Wang
Background/Aims: Recently, water exchange (WE) instead of water immersion (WI) for colonoscopy has been proposed to decrease pain and improve adenoma detection rate (ADR). This systematic review and meta-analysis is conducted to assess whether WE is superior to WI based on the published randomized controlled trials (RCTs). Materials and Methods: We searched studies from PubMed, Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE. Only RCTs were eligible for our study...
June 5, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29873318/protective-association-of-tnfsf15-polymorphisms-with-crohn-s-disease-and-ulcerative-colitis-a-meta-analysis
#10
REVIEW
Liwen He, Jiamin Chen, Jiachen Sun, Junsheng Peng, Qing He
Background/Aims: Three extensively investigated polymorphisms (rs3810936, rs7848647, and rs6478108) in tumor necrosis factor super family member 15 (TNFSF15) gene have been implicated in risk for inflammatory bowel disease (IBD). We performed a quantitative synthesis of the evidence to clarify these associations of TNFSF15 polymorphisms with IBD. Materials and Methods: Data were extracted from PubMed and EMBASE, up to March 15, 2018. Meta-analysis was performed by critically reviewing five studies for rs3810936 polymorphism (2251 cases and 2442 controls), four studies for rs7848647 polymorphism (1503 cases and 1816 controls), and four studies for rs6478108 polymorphism (1502 cases and 1817 controls)...
June 5, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29873317/correlated-non-nuclear-cox2-and-low-her2-expression-confers-a-good-prognosis-in-colorectal-cancer
#11
Fei-Fei Zhou, Rong Huang, Jun Jiang, Xiao-Hong Zeng, Shu-Qian Zou
Background/Aims: COX2 and HER2 are shown to be critical in the regulation of cancer progression. However, the prognostic value of nuclear COX2 in colorectal cancer (CRC) and its relationship with HER2 still remains unknown. In this study, the expression and biological significance of COX2 and HER2 were evaluated in CRC at mRNA and protein levels. Materials and Methods: RNA-Seq data of CRC were downloaded from TCGA, and 229 CRC and 50 non-cancerous subjects were enrolled in this study...
June 5, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29873316/the-role-of-the-plr-nlr-combination-in-the-prediction-of-the-presence-of-helicobacter-pylori-and-its-associated-complications
#12
Mustafa Kaplan, Ihsan Ates, Mahmut Yuksel, Mehmet F Arikan, Gulden Aydog, Nesrin Turhan, Volkan Gökbulut, Ertugrul Kayacetin
Background/Aim: The aim of this study was to investigate the role of the platelet-to-lymphocyte ratio (PLR)-neutrophil-to-lymphocyte ratio (NLR) combination, in the prediction of the presence of Helicobacter pylori (HP) and its associated complications in the gastrointestinal system. Patients and Methods: In all, 1289 patients who underwent esophagogastroduodenoscopy and biopsy for HP were included in the study. Results: The ratio of patients with moderate and severe chronic gastritis was higher in HP (+) group than HP (-) group...
June 5, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29806597/expression-and-significance-of-interleukin-17-and-interleukin-22-in-the-serum-and-the-lower-esophageal-sphincter-of-patients-with-achalasia
#13
Zeyu Wang, Jun Zhang, Jianwei Mi, Huihui Ma, Dongqiang Zhao
Background/Aim: : We studied the expression of interleukin-17 and interleukin-22 in the serum and the lower esophageal sphincter (LES) in healthy individuals and in patients diagnosed with achalasia (AC) to gain a better understanding of the etiopathogenesis of AC. Patients and Methods: Our study comprised 14 randomly selected patients with AC who underwent peroral endoscopic myotomy and 14 randomly selected healthy individuals who served as controls. Venous blood samples were evaluated in all study subjects to detect the expression of interleukin-17 and interleukin-22 in the serum using an enzyme-linked immunosorbent assay...
May 28, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29806596/gastric-adenocarcinoma-expressing-human-epidermal-growth-factor-receptor-in-south-asian-population
#14
Asma Shabbir, Muhammad Asif Qureshi, Abdullah Bin Khalid, Talat Mirza, Asma Shaikh, Syed Mehmood Hasan
Background/Aim: Gastric cancer is the third leading cause of cancer mortality worldwide. Human epidermal growth factor (Her-2/neu) has shown strong therapeutic implication in breast cancer. Although the prevalence of Her-2/neu over-expression in gastric cancer has been reported across the world, it is still unknown from South Asia. The aim of this study is to evaluate Her-2/neu expression in gastric adenocarcinomas and to correlate with various clinicopathological variables. Patients and Methods: A total of 95 consecutive patients undergoing endoscopic biopsy or gastrectomy were recruited in this study...
May 28, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29798943/colorectal-cancer-a-looming-threat-opportunities-and-challenges-for-the-saudi-population-and-its-healthcare-system
#15
LETTER
Mohammad Azhar Aziz, Haafiz Allah-Bakhsh
No abstract text is available yet for this article.
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29798942/clinical-and-prognostic-significance-of-muc1-expression-in-patients-with-esophageal-squamous-cell-carcinoma-after-radical-resection
#16
Zhi-Gang Sun, Li Yu, Wei Gao, Zhou Wang, Liang-Ming Zhu
Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection. Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level. Results: MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases...
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29676289/natural-history-and-outcome-of-inflammatory-bowel-diseases-in-children-in-saudi-arabia-a-single-center-experience
#17
Khalid M Alreheili, Khalid A Alsaleem, Ali I Almehaidib
Background/Aim: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder which includes ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis (IC). The natural history of pediatric IBDs is poorly understood and generally unpredictable. We aim to study the natural history of IBD in Saudi children including the extraintestinal manifestations, changes in diagnosis, disease behavior, medical management, and surgical outcome. Patients and Methods: A retrospective review of all the charts of children less than 14 years of age who were diagnosed as IBD and followed up in King Faisal Specialist Hospital and Research Center (KFSH and RC) from January 2001 to December 2011 was performed...
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29652035/preoperative-biliary-drainage-in-pancreatic-head-cancer-patients
#18
EDITORIAL
Emad S Aljahdli
No abstract text is available yet for this article.
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29652034/prevalence-of-sleep-disorder-in-irritable-bowel-syndrome-a-systematic-review-with-meta-analysis
#19
REVIEW
Ben Wang, Ruqiao Duan, Liping Duan
Background/Aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder. Materials and Methods: A systematic search was conducted by searching PubMed, Embase, and Cochrane library databases using the following search terms: "functional gastrointestinal disorders," "Sleep disturbance," "Sleep disorder," "insomnia," "Dysomnias," "irritable bowel syndrome," and "IBS...
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29652031/association-between-patient-characteristics-and-magnetically-controlled-capsule-endoscopy-findings
#20
Huasheng Lai, Junsheng Huang, Yangzhi Xu, Jie Zhang, Zhenyu Chen, Fengcheng Xi, Aimin Li, Side Liu
Background/Aim: Magnetically-controlled capsule endoscopy (MCE) is a potential option for the evaluation of gastric diseases in cases that are unsuited for conventional endoscopy, avoiding discomfort, sedation, and related complications. This retrospective study investigated associations between MCE findings and patient gender, age, and inpatient/outpatient status. Patients and Methods: The data of 580 consecutive patients who underwent MCE from 2015 to 2016 were analyzed...
May 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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