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JOURNAL ARTICLE
Geert V T Roozen, Manon L M Prins, Corine Prins, Jacqueline J Janse, Heidi L M de Gruyter, Cilia R Pothast, Wesley Huisman, Jan Pieter R Koopman, Olivia A C Lamers, Marjan Kuijer, Sebenzile K Myeni, Rob S van Binnendijk, Gerco den Hartog, Mirjam H M Heemskerk, Simon P Jochems, Mariet C W Feltkamp, Marjolein Kikkert, Frits R Rosendaal, Meta Roestenberg, Leo G Visser, Anna H E Roukens
OBJECTIVES: The aim of this study was to assess safety and immunogenicity of a dose-sparing fractional intradermal (ID) booster strategy with the mRNA-1273 COVID-19 vaccine. METHODS: COVID-19 naive adults aged 18-30 years were recruited from a previous study on primary vaccination regimens that compared 20 μg ID vaccinations with 100 μg IM vaccinations with mRNA-1273 as the primary vaccination series. Participants previously immunized with ID regimens were randomly assigned (1:1) to receive a fractional ID booster dose (20 μg) or the standard-of-care intramuscular (IM) booster dose (50 μg) of the mRNA-1273 vaccine, six months after completing their primary series (ID-ID and ID-IM group, respectively)...
March 27, 2024: Clinical Microbiology and Infection
#22
JOURNAL ARTICLE
Léa Poussier, Alexandra Mailles, Pierre Tattevin, Jean Paul Stahl, Pierre Fillatre
OBJECTIVE: To characterize differences between Herpes Simplex Virus and Varicella-Zoster Virus encephalitis (HSVE and VZVE) and other aetiologies of infectious encephalitis (IE), and to investigate the impact of time-to-aciclovir (ACV) start, ACV dose and duration on outcome. METHODS: We compared 132 HSVE, 65 VZVE, and 297 others IE enrolled in a prospective cohort (ENCEIF). We estimated associations between time-to-ACV start, dose or duration and outcome through adjusted odds-ratio (aOR) using logistic regression analysis...
March 23, 2024: Clinical Microbiology and Infection
#23
JOURNAL ARTICLE
Joël Coste, Cyrille Delpierre, Jean-Baptiste Richard, Caroline Alleaume, Anne Gallay, Sarah Tebeka, Cédric Lemogne, Olivier Robineau, Olivier Steichen, Tatjana T Makovski
OBJECTIVES: Long COVID is recognized since early 2020, but its definition is not unanimous, which complicates epidemiological assessments. This study estimated the prevalence of long COVID based on several definitions and severity thresholds in the adult population in mainland France and examined variations according to sociodemographic and infection characteristics. METHODS: A cross-sectional survey using random sampling was conducted in August-November 2022. Participants declaring SARS-CoV-2 infection were assessed for infection dates and context, post-COVID symptoms (from a list of 31, with onset time, daily functioning impact, alternative diagnosis) and perceived long COVID...
March 23, 2024: Clinical Microbiology and Infection
#24
JOURNAL ARTICLE
Shang-Yi Lin, Ho-Yin Huang, Lin-Li Chang, Ya-Ling Wang, Tun-Chieh Chen, Ko Chang, Hung-Pin Tu, Po-Liang Lu
OBJECTIVES: The trailing effect of Candida species is a phenomenon characterized by reduced but persistent growth at antifungal concentrations above the minimal inhibitory concentration (MIC). We assessed the impact of trailing growth on the persistence of Candida albicans candidemia in patients receiving fluconazole therapy. METHODS: We retrospectively investigated candidemia isolates at three hospitals in southern Taiwan between 2013 and 2020. Patients treated with fluconazole for fluconazole-susceptible C...
March 23, 2024: Clinical Microbiology and Infection
#25
JOURNAL ARTICLE
Anders Boyd, Mariam El Dani, Roula Ajrouche, Vanessa Demontant, Justine Cheval, Karine Lacombe, Guillaume Cosson, Christophe Rodriguez, Jean-Michel Pawlotsky, Paul-Louis Woerther, Laure Surgers
OBJECTIVE: Little is known on the effect of gut microbial and Extended-Spectrum β-Lactamase-Producing Enterobacterales (ESBL-E) carriage, particularly in the general population. The aim of this study was to identify microbiota signatures uniquely correlated with ESBL-E carriage. METHODS: We conducted a case-control study among individuals seeking care at the Sexual Health Clinic or Department of Infectious and Tropical Diseases at Saint-Antoine Hospital, Paris, France...
March 23, 2024: Clinical Microbiology and Infection
#26
JOURNAL ARTICLE
J Stanley, B Sullivan, A W Dowsey, K Jones, C R Beck
OBJECTIVES: Between 2016-19, the proportion of Escherichia coli bloodstream infection (BSI) with resistance to at least one antibiotic increased nationally. Public health interventions implemented in response to the coronavirus disease 2019 (COVID-19) pandemic changed population contact patterns and healthcare systems, with consequent effects on epidemiological trends of numerous pathogens. We investigated the impact of COVID-19 restrictions on epidemiological trends of E. coli BSI antimicrobial resistance (AMR) across South West England...
March 23, 2024: Clinical Microbiology and Infection
#27
REVIEW
Marta Pozuelo Torres, Jakko van Ingen
BACKGROUND: Antibiotic treatment of Mycobacterium abscessus disease is toxic, poorly effective and lacks a firm evidence base. Dual β-lactam and β-lactam/β-lactamase inhibitor combinations may be interesting leads to improve treatment outcomes. OBJECTIVES: To summarize the current preclinical studies on dual β-lactam and β-lactam/β-lactamase inhibitor combinations against Mycobacterium abscessus. SOURCES: We performed a literature search using the NCBI's PubMed interface with additional snowball sampling...
March 23, 2024: Clinical Microbiology and Infection
#28
JOURNAL ARTICLE
Neha Bhardwaj, Ashish Aggarwal, Harsimran Kaur, Shivaprakash M Rudramurthy, Kirti Gupta
No abstract text is available yet for this article.
March 22, 2024: Clinical Microbiology and Infection
#29
Zhou G, Luo S, He J, Chen N, Zhang Y, Cai S, Guo X, Chen H, Song C
No abstract text is available yet for this article.
March 22, 2024: Clinical Microbiology and Infection
#30
JOURNAL ARTICLE
Gaillard Tiphaine, Dupieux-Chabert Céline, Roux Anne-Laure, Tessier Eve, Boutet-Dubois Adeline, Courboules Camille, Corvec Stéphane, Bémer Pascale, Lavigne Jean-Philippe, El Sayed Faten, Marchandin Hélène, Munier Clément, Chanard Emmanuel, Gazzano Vincent, Loiez Caroline, Laurent Frédéric
OBJECTIVES: To assess the performance of the rapid syndromic BioFire® Joint Infection panel (BF-JIP) to detect bacterial and fungal pathogens, as well as antibiotic resistance genes, directly in synovial fluid specimens collected in patients with acute arthritis. METHODS: The study was conducted in six French bacteriological laboratories. To assess the performances of BF-JIP, results were compared with those of synovial fluid 14-day culture, and in case of discrepancy, with those of complementary molecular methods and intraoperative samples...
March 22, 2024: Clinical Microbiology and Infection
#31
JOURNAL ARTICLE
Sue C Nang, Jing Lu, Heidi H Yu, Hasini Wickremasinghe, Mohammad A K Azad, Meiling Han, Jinxin Zhao, Gauri Rao, Phillip J Bergen, Tony Velkov, Norelle Sherry, David T McCarthy, Saima Aslam, Robert T Schooley, Benjamin P Howden, Jeremy J Barr, Yan Zhu, Jian Li
OBJECTIVES: Bacteriophage (phage) therapy is a promising anti-infective option to combat antimicrobial resistance. However, the clinical utilisation of phage therapy has been severely compromised by the potential emergence of phage resistance. While certain phage resistance mechanisms can restore bacterial susceptibility to certain antibiotics, a lack of knowledge of phage resistance mechanisms hinders optimal use of phages and their combination with antibiotics. METHODS: Genome-wide transposon screening was performed with a mutant library of Klebsiella pneumoniae MKP103 to identify phage pKMKP103_1-resistant mutants...
March 22, 2024: Clinical Microbiology and Infection
#32
JOURNAL ARTICLE
Ilaria Baccani, Alberto Antonelli, Sara Cuffari, Caterina Ferretti, Tommaso Giani, Gian Maria Rossolini
OBJECTIVES: This study aims to evaluate two commercial broth microdilution (BMD) systems, E1-185-100 (Merlin) and FDANDPF (ThermoFisher) for dalbavancin susceptibility testing in comparison with reference broth microdilution assay. METHODS: Study collection was composed of 200 nonreplicate multidrug-resistant Gram-positive cocci of clinical origin, including 180 methicillin-resistant Staphylococcus aureus, 10 vancomycin resistant enterococci, 7 linezolid resistant Staphylococcus epidermidis, and 3 methicillin-resistant coagulase negative staphylococci...
March 14, 2024: Clinical Microbiology and Infection
#33
LETTER
Axelle Roblin, Marie Lachâtre, Caroline Charlier, Odile Launay, Vassilis Tsatsaris, Olivia Anselem
No abstract text is available yet for this article.
March 14, 2024: Clinical Microbiology and Infection
#34
JOURNAL ARTICLE
Gunar Günther, Lorenzo Guglielmetti, Yousra Kherabi, Raquel Duarte, Christoph Lange, Tonia Adamides, Onno Akkerman, Aase Bengaard Andersen, Ágnes Bakos, Agnar Bjarnason, Judith Bruchfeld, Dumitru Chesov, Luigi Ruffo Codecasa, Daniela Cirillo, Manfred Danilovits, Edita Davidavičienė, Raquel Duarte, Maria Luiza De Souza Galvão, Sandrine Garnier, Majlinda Gjocaj, Gunar Günther, Elmira Ibraim, Michael Kappnik, Naira Khachatryan, Dzmitry Klimuk, Liga Kuksa, Mathilde Frechet Jachym, Kamilla Josefsdottir, Anna Kaluzhenina, Christoph Lange, Ulrich Mack, Mateja Jankovic Makek, Katerina Manika, Anne-Marie Mclaughlin, Donika Mema, Anne Torunn Mengshoel, Inge Muylle, Zorica Nanovic, Şeref Özkara, Sivan Perl, Dragica Pesut, Despo Pierdou, Galym Ryskulov, Marcin Skowroński, Ivan Solovic, Mariia Sukholytka, Petra Svetina, Yana Terleeva, Simon Tiberi, Tamara Togonidze, Stefania Torri, Laziz Turaev, Ruzilya Usmanova, Gil Wirtz, Tuula Vasankari, Elena Zhdanova
OBJECTIVES: Multidrug-resistant/Rifampicin-resistant tuberculosis (TB) is a major obstacle to successful TB control. The recommendation by the World Health Organization to use bedaquiline, pretomanid, linezolid and moxifloxacin (BPaL(M)) for 6 months, based on results of three trials with high efficacy and low toxicity, has revolutionized treatment options. METHODS: In this study, representatives of the Tuberculosis Network European Trialsgroup (TBnet) in 44/54 countries of the WHO Europe region document the availability of the medicines and drug susceptibility testing (DST) of the BPaL(M) regimen through a structured questionnaire between September to November 2023...
March 13, 2024: Clinical Microbiology and Infection
#35
JOURNAL ARTICLE
Nora Chekrouni, Thijs M van Soest, Ana C da Cruz Campos, Matthijs C Brouwer, Diederik van de Beek
OBJECTIVES: The objective of this study was to determine the role of cerebrospinal fluid (CSF) bacterial load in adults with pneumococcal meningitis. METHODS: We quantified bacterial load in CSF samples from the diagnostic lumbar puncture of adults with community-acquired pneumococcal meningitis. We also measured CSF concentrations of complement 5a (C5a), and determined associations between bacterial load, clinical characteristics, C5a and unfavourable outcome (Glasgow Outcome Scale score<5)...
March 11, 2024: Clinical Microbiology and Infection
#36
REVIEW
Lisanne M van Leeuwen, Elandri Fourie, Gerrie van den Brink, Vincent Bekker, Marlies A van Houten
BACKGROUND: An accurate diagnosis of early-onset sepsis (EOS) is challenging because of subtle symptoms and the lack of a good diagnostic tool, resulting in considerable antibiotic overtreatment. A biomarker, discriminating between infected and non-infected newborns at an early stage of the disease, could improve EOS prediction. Numerous biomarkers have been tested, but have never been compared directly. OBJECTIVES: We aimed to provide a comprehensive overview of early biomarkers and their diagnostic value in maternal samples, umbilical cord blood, and neonatal serum...
March 11, 2024: Clinical Microbiology and Infection
#37
JOURNAL ARTICLE
Nicolas Banholzer, Pascal Bittel, Philipp Jent, Lavinia Furrer, Kathrin Zürcher, Matthias Egger, Tina Hascher, Lukas Fenner
OBJECTIVES: To compare the prevalence of SARS-CoV-2 and other respiratory viruses in saliva and bioaerosols between two winters and to model the probability of virus detection in classroom air for different viruses. METHODS: We analysed saliva, air, and air cleaner filter samples from studies conducted in two Swiss secondary schools (students aged 14-17 years) over 7 weeks during the winters of 2021/22 and 2022/23. Two bioaerosol sampling devices and high efficiency particulate air (HEPA) filters from air cleaners were used to collect airborne virus particles in four classrooms...
March 10, 2024: Clinical Microbiology and Infection
#38
LETTER
Plüss-Suard Catherine, Mueller Yolanda, Plate Andreas, Senn Oliver, Kronenberg Andreas
No abstract text is available yet for this article.
March 9, 2024: Clinical Microbiology and Infection
#39
LETTER
Re: Unexpected increase of severe Mycoplasma pneumoniae pneumonia in adults in Southern Switzerland.
Christian Garzoni, Enos Bernasconi, Cinzia Zehnder, Simona Frigerio Malossa, Giorgio Merlani, Marco Bongiovanni
No abstract text is available yet for this article.
March 9, 2024: Clinical Microbiology and Infection
#40
REVIEW
Lisa Kriegl, Matthias Egger, Johannes Boyer, Martin Hoenigl, Robert Krause
BACKGROUND: Yet often overlooked in public health discourse, fungal infections pose a crucialglobal disease burden associated with annual mortality rates approximately equal to tuberculosis and HIV. In response, the World Health Organization (WHO) published its first global priority list of fungal pathogens in 2022 assigning Aspergillus fumigatus, Candida albicans, Candida auris, and Cryptococcus neoformans to the critical group. OBJECTIVES: This review provides succinct insights on novel antifungals in development, aiming to contribute valuable information and perspectives with focus on recent clinical findings and new treatment approaches for critical members of the WHO fungal pathogen priority list...
March 8, 2024: Clinical Microbiology and Infection
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