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Clinical Microbiology and Infection

Miłosz Parczewski, Justyna Kordek, Ewa Janczewska, Arkadiusz Pisula, Władysław Łojewski, Łukasz Socha, Marta Wawrzynowicz-Syczewska, Monika Bociąga-Jasik, Aleksandra Szymczak, Iwona Cielniak, Ewa Siwak, Elżbieta Mularska, Bogusz Aksak-Wąs, Anna Urbańska, Nadine Luebke
OBJECTIVES: The aim of the study was to characterize the differences in the NS3 and NS5A resistance-associated variants (RAVs) frequencies among Polish therapy naïve genotype 1 (G1) HCV-monoinfected and HIV/HCV-coinfected patients including clustering patterns and association of RAVs frequency with the liver fibrosis. METHODS: NS3/NS5A RAVs were identified by population sequencing in 387 directly acting antiviral (DAA) treatment naive G1-infected individuals [54 with genotype 1a (G1a) and 333 with genotype 1b (G1b)]...
July 5, 2018: Clinical Microbiology and Infection
Laura Varela Barca, Jose López-Menéndez, Ana Redondo Palacios, Jorge Rodríguez-Roda
No abstract text is available yet for this article.
July 4, 2018: Clinical Microbiology and Infection
Jianling Xie, Alberto Nettel-Aguirre, Bonita E Lee, Linda Chui, Xiao-Li Pang, Ran Zhuo, Brendon Parsons, Otto G Vanderkooi, Phillip I Tarr, Samina Ali, James A Dickinson, Evan Hagen, Lawrence W Svenson, Shannon E MacDonald, Steven J Drews, Raymond Tellier, Timothy Graham, Martin Lavoie, Judy MacDonald, Stephen B Freedman
OBJECTIVES: To evaluate the relationship between individual bacterial and viral pathogens and severity. METHODS: Children <18 years with ≥3 episodes of vomiting and/or diarrhoea were enrolled in two Canadian paediatric emergency departments between December 2014 and August 2016. Specimens were analysed employing molecular panels and outcome data was collected 14 days following enrolment. The primary outcome was severe disease over the entire illness (symptom onset until 14-day follow-up), quantified employing the Modified Vesikari Scale (MVS) score...
June 28, 2018: Clinical Microbiology and Infection
J Friedman
No abstract text is available yet for this article.
June 28, 2018: Clinical Microbiology and Infection
Ana Collazos Blanco, Felipe Pérez-García, Carlos Sánchez-Carrillo, Viviana de Egea, Patricia Muñoz, Emilio Bouza
OBJECTIVES: The question of whether to obtain 2 or 3 sets of blood cultures to assess the etiology of bloodstream infections (BSIs) remains open to debate. Few studies have assessed the proportion of BSIs missed without the third blood culture set (BCS). The aim of our study was to determine the proportion of BSIs that would be missed without the third BCS in a hospital where obtaining 3 BCSs is the standard of care. METHODS: We performed a descriptive retrospective study in Hospital Gregorio Marañón (Madrid) from 2010 to 2013...
June 28, 2018: Clinical Microbiology and Infection
Hongxing Li, Lulu Liu, Wei Zhou, Yuwen Rui, Binchan He, Yi Shi, Xin Su
OBJECTIVES: Pentraxin 3 (PTX3) contributes to resistance to Aspergillus infections, this study aimed to evaluate the presence of PTX3 in bronchoalveolar lavage fluid (BALF) and plasma in non-neutropenic patients with pulmonary aspergillosis. METHODS: BALF (n=211) and plasma samples (n=307) were collected from patients initially suspected of having pulmonary aspergillosis. Among these, 112 cases were proven to be pulmonary aspergillosis (51BALF samples and 89plasma samples)...
June 28, 2018: Clinical Microbiology and Infection
Mark S Riddle, Wilbur H Chen, Carl D Kirkwood, Calman A MacLennan
BACKGROUND: Acute diarrheal disease caused by viral, bacterial and parasitic infections is a major global health problem with substantial mortality and morbidity in children under 5 in low- and middle-income countries (LMICs). A number of these infections also impact large segments of populations in high-income countries (HICs), as well as individuals who travel overseas for work, business or pleasure. AIMS: The aim of this review is to describe the current landscape of licensed enteric vaccines, potential new vaccines on the horizon, and the challenges of development and utilization of vaccines against enteric pathogens...
June 28, 2018: Clinical Microbiology and Infection
Falcone Marco, Tiseo Giusy, Iraci Federica, Raponi Giammarco, Goldoni Paola, Delle Rose Diego, Santino Iolanda, Carfagna Paolo, Murri Rita, Fantoni Massimo, Fontana Carla, Sanguinetti Maurizio, Farcomeni Alessio, Antonelli Guido, Aceti Antonio, Mastroianni Claudio, Andreoni Massimo, Cauda Roberto, Petrosillo Nicola, Venditti Mario
OBJECTIVES: Our objective was to evaluate factors associated with recurrence in patients with 027+ Clostridium difficile infection (CDI) and 027- CDI. MATERIALS/METHODS: Patients with CDI observed between January and December 2014 in 6 hospitals were consecutively included in the study. The 027 ribotype was deducted by the presence of tcdB, tcdB, cdt genes and the deletion Δ117 of tcdC (Xpert® C. difficile/Epi). Recurrence was defined as a positive laboratory test result for C...
June 28, 2018: Clinical Microbiology and Infection
Eric Batard, François Javaudin, Erwan Kervagoret, Emmanuel Caruana, Quentin Le Bastard, Guillaume Chapelet, Nicolas Goffinet, Emmanuel Montassier
OBJECTIVES: We aimed to assess whether treatment with ceftriaxone/cefotaxime was associated with lower in-hospital mortality than amoxicillin-clavulanate in patients hospitalized in medical wards for community-onset pneumonia. METHODS: We conducted a retrospective and multicentre study of patients hospitalized in French medical wards for community-onset pneumonia between 2002 and 2015. Treatments with ceftriaxone/cefotaxime or amoxicillin-clavulanate were defined by their start in the Emergency Department for a duration of 5 days or more and no other beta-lactam...
June 28, 2018: Clinical Microbiology and Infection
Gili Regev-Yochay
No abstract text is available yet for this article.
June 27, 2018: Clinical Microbiology and Infection
E Bottieau, C P Yansouni
No abstract text is available yet for this article.
June 22, 2018: Clinical Microbiology and Infection
M Puges, F Gabriel, M Carrer, S Perez, H Boijout, H Dutronc, C Cazanave
No abstract text is available yet for this article.
June 22, 2018: Clinical Microbiology and Infection
Liz Paul
Nipah virus is a rare but dreaded zoonotic pathogen causing infections with alarmingly high mortality rates of 40-75 %. The ongoing outbreak in Kerala has witnessed 16 cases so far out of which 13 succumbed .The situation has created total panic and false perceptions among the public. As a Clinical Microbiologist belonging to the affected area, my contribution is giving health education and implementing strict infection control practices in the laboratory and in the hospital . ( As a part of Roles and responsibilities as Infection control officer of my Hospital)...
June 20, 2018: Clinical Microbiology and Infection
Mercedes Marín, Adrián Ruiz, Cristina Iglesias, Lidia Quiroga, Emilia Cercenado, Pablo Martín-Rabadán, Emilio Bouza, Belén Rodríguez-Sánchez
OBJECTIVES: The identification of Nocardia isolates still represents a challenge for MALDI-TOF MS despite its acceptance for most bacterial and fungal isolates. In this study we evaluate the identification of Nocardia isolates using direct spotting and an updated database. METHODS: Overall, 82 Nocardia isolates belonging to 13 species were identified by DNA sequence analysis of the 16S rRNA and secA1 genes. Nine of these well-characterized isolates from 6 Nocardia species were used to create an in-house library...
June 19, 2018: Clinical Microbiology and Infection
David Lebeaux, Emmanuelle Bergeron, Jérémy Berthet, Juliette Djadi-Prat, Delphine Mouniée, Patrick Boiron, Olivier Lortholary, Véronica Rodriguez-Nava
OBJECTIVES: Nocardia, a Gram-positive bacterium, is responsible for rare and severe infections. Accurate microbiological data are essential to guide antibiotic treatment. Our primary objective was to describe species identification and results of antimicrobial susceptibility testing (AST) for Nocardia isolates analysed over a 6-year period. Secondary objectives were to study temporal trends in species distribution and AST results. METHODS: We retrospectively analysed results from Nocardia isolates sent between January 2010 and December 2015 to a French laboratory dedicated to Nocardia (Observatoire Français des Nocardioses)...
June 19, 2018: Clinical Microbiology and Infection
A Kritikos, D Neofytos, N Khanna, P W Schreiber, K Boggian, J Bille, J Schrenzel, K Mühlethaler, R Zbinden, T Bruderer, D Goldenberger, G Pfyffer, A Conen, C Van Delden, S Zimmerli, D Sanglard, D Bachmann, O Marchetti, F Lamoth
OBJECTIVES: Echinocandins represent the first-line treatment of candidemia. Acquired echinocandin resistance is mainly observed among Candida albicans and glabrata and is associated with FKS hotspot mutations. The commercial Sensititre YeastOneTM (SYO) kit is widely used for antifungal susceptibility testing, but interpretive clinical breakpoints are not well defined. We determined echinocandins epidemiological cut-off values (ECV) for C. albicans/glabrata tested by SYO and assessed their ability to identify FKS mutants in a national survey of candidemia...
June 14, 2018: Clinical Microbiology and Infection
Henrique Pott Junior, Guilherme Bricks, Giuliano Grandi, Jorge Figueiredo Senise, Adauto Castelo Filho
OBJECTIVES: This study aimed to investigate the efficacy and safety of sofosbuvir plus daclatasvir (SOF+DCV) or simeprevir (SOF+SMV) in a randomized, open-label, non-inferiority trial of patients infected with hepatitis c virus (HCV) genotype 1, who were previously unresponsive to pegylated interferon and ribavirin or were treatment-naïve. METHODS: Patients were randomly assigned to receive SOF (400 mg once daily) plus DCV (60 mg once daily) or SMV (150 mg once daily) for 12 weeks...
June 12, 2018: Clinical Microbiology and Infection
Gamze Kilicoglu, Derya Ozturk-Engin, Hülya Tireli, Yasemin Cağ, Gonul Sengöz, Seniha Senbayrak, Hakan Erdem
No abstract text is available yet for this article.
June 12, 2018: Clinical Microbiology and Infection
Marina R Pulido, Verónica González-Galán, Felipe Fernández Cuenca, Álvaro Pascual, José Garnacho-Montero, Massimo Antonelli, George Dimopoulos, José A Lepe, Michael J McConnell, José Miguel Cisneros
OBJECTIVE: The objective of this study was to evaluate the ability of the BioFire FilmArray Blood Culture Identification (BCID) Panel to rapidly detect pathogens producing late-onset ventilator-associated pneumonia (VAP), a severe infection often produced by Gram negative bacteria. These microorganisms are frequently multidrug resistant (MDR) and typically require broad spectrum empiric treatment. METHODS: In this study, in the context of an international multicenter clinical trial (Magic Bullet), respiratory samples were collected at the time of suspicion of VAP from 165 patients in 32 participating hospitals in Spain, Greece and Italy...
June 12, 2018: Clinical Microbiology and Infection
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