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Clinical Microbiology and Infection

Rixt Wijma, Birgit Koch, Teun van Gelder, Johan Mouton
No abstract text is available yet for this article.
November 8, 2018: Clinical Microbiology and Infection
O J Dyar, B Beović, C Pulcini, E Tacconelli, M Hulscher, B Cookson
OBJECTIVE: To develop a consensus-based set of generic competencies in antimicrobial prescribing and stewardship for European prescribers through a structured consensus procedure. METHODS: The RAND-modified Delphi procedure comprised two online questionnaire rounds, a face-to-face meeting between rounds, and a final review. Our departure point was a set of competencies agreed previously by consensus among a UK multi-disciplinary panel, and which had been subsequently revised through consultation with ESCMID Study Group representatives...
November 3, 2018: Clinical Microbiology and Infection
Johannes G Liese, Christoph Schoen, Mark van der Linden, Lisa Lehmann, David Goettler, Sabrina Keller, Anna Maier, Florian Segerer, Markus A Rose, Andrea Streng
OBJECTIVES: Parapneumonic pleural effusions/empyema (PPE/PE) are severe complications of community- acquired pneumonia. We investigated the bacterial aetiology and incidence of paediatric PPE/PE in Germany after the introduction of universal pneumococcal conjugate vaccine (PCV) immunisation for infants. METHODS: Children <18 years of age hospitalised with pneumonia-associated PPE/PE necessitating pleural drainage or persisting >7 days were reported to the German Surveillance Unit for Rare Diseases in Childhood from October 2010 to June 2017...
November 2, 2018: Clinical Microbiology and Infection
Mohammadreza Salehi, Ensieh Zibafar, Shahram Mahmoudi, Seyed Jamal Hashemi, Seyed Mansour Gatmiri, Mohsen Gerami Shoar, Seyed Ali Dehghan Manshadi, Behnaz Jahanbin, Ramazanali Alizadeh, Leila Hosseinpour, Pegah Ardi, Roshanak Daie Ghazvini
Didymella microchlamydospora is a recently established species usually causing plant diseases. This report represents the first case of invasive pulmonary infection due to this fungus in a 50-year-old male with history of immunosuppression. Patient infection improved by prescribing voriconazole.
October 31, 2018: Clinical Microbiology and Infection
Pippa Oakeshott, Sarah Kerry-Barnard, Charlotte Fleming, Rachel Phillips, Vari M Drennan, Elisabeth J Adams, Wendy Majewska, Emma M Harding-Esch, Emma C Cousins, Tim Planche, Alastair Green, Rosalie I Bartholomew, S Tariq Sadiq, Fiona Reid
OBJECTIVES: We conducted a cluster-randomised feasibility trial of 90-minute Chlamydia trachomatis tests and same day on-site treatment ("Test n Treat/TnT") in six technical colleges in London, England to assess: • TnT uptake rates • Follow-up rates • Prevalence of C.trachomatis at baseline and 7-months • Time to treatment • Acceptability of TnT METHODS: Participants completed questionnaires and provided genitourinary samples at baseline and seven months. Participants were informed that baseline samples would not be tested for 7- months and advised to get screened independently...
October 31, 2018: Clinical Microbiology and Infection
Adam Polkinghorne, Nicole Borel, Marloes Heijne, Yvonne Pannekoek
Recent reports highlight a growing awareness of the potential for Chlamydia considered to be traditionally veterinary pathogens to cause cases of community-acquired pneumonia in humans. Cases of Chlamydia caviae, a guinea pig pathogen, were detected in individuals with serious pneumonia requiring hospitalisation. Source tracking linked these infections to pet guinea pigs. Studies of horses have found that the avian and zoonotic pathogen, Chlamydia psittaci, may be more common in these mammalian hosts, further highlighting the risk of exposure to chlamydial causes of CAP...
October 27, 2018: Clinical Microbiology and Infection
Sherwin K B Sy, Luning Zhuang, Huiming Xia, Virna J Schuck, Wright W Nichols, Hartmut Derendorf
OBJECTIVE: The aim of the present work was to use a semi-mechanistic, mathematical, PK-PD model developed from in-vitro time-kill measurements with P. aeruginosa to compare different pharmacodynamic indices derived from simulated human avibactam exposures, with respect to their degree of correlation with the modeled bacterial responses. METHODS: A mathematical model of the effect of ceftazidime-avibactam on the growth dynamics of P. aeruginosa was used to simulate bacterial responses to modeled human exposures from fractionated avibactam dosing regimens with a fixed ceftazidime dosing regimen (2 or 8 g q8h as 2-h infusion)...
October 27, 2018: Clinical Microbiology and Infection
Damien Dupont, Anne-Cécile Normand, Florence Persat, Marijke Hendrickx, Renaud Piarroux, Martine Wallon
OBJECTIVES: The purpose of this study was to compare the efficiency of mould identification of two MALDI-TOF MS systems - Vitek MS and Microflex LT - and the MSI application. METHODS: Moulds were collected retrospectively and prospectively to display epidemiological diversity of a microbiology lab. All of them were identified via sequencing. Strains were then identified using the VMS v3.0, the MLT and the MSI software applied on MLT spectra. Rates of correct identifications to the species, to the complex level and to the genus level were compared to the molecular Gold Standard...
October 27, 2018: Clinical Microbiology and Infection
Melissa M Remy, Michèle Alfter, Manh-Nhi Chiem, Maria Teresa Barbani, Olivier B Engler, Franziska Suter-Riniker
OBJECTIVES: Highly pathogenic viruses such as Ebola virus are a threat to routine laboratory workers. Inactivation procedures with Triton X-100 0.1% and/or heat are currently recommended, but have unknown effects on the accuracy of serological testing. Furthermore, virus inactivation by Triton X-100 0.1% was shown to be ineffective in serum. This study aimed to demonstrate virus inactivation in serum by Triton X-100 1% and maintained accuracy of serological testing. METHODS: A panel of 19 serological tests was run on patient serum samples after treatment with Triton X-100 1%, 0...
October 27, 2018: Clinical Microbiology and Infection
K Wagner, F Imkamp, V P Pires, P M Keller
OBJECTIVE: Rapid detection of macrolide resistance-associated mutations in Mycoplasma pneumoniae is crucial for effective antimicrobial treatment. In this study, we evaluated the Lightmix® Mycoplasma macrolide assay for the detection of point mutations at nucleotide position 2063 and 2064 in the 23S rRNA gene of M. pneumoniae that confer macrolide resistance. METHODS: Samples from 3438 patients suffering from respiratory tract infection were analyzed by M. pneumoniae real-time polymerase chain reaction (RT-PCR), and 208 (6%) of them were tested positive...
October 25, 2018: Clinical Microbiology and Infection
Ivan S Pradipta, Natasha Van't Boveneind-Vrubleuskaya, Onno W Akkerman, Jan-Willem C Alffenaar, Eelko Hak
OBJECTIVES: We evaluated treatment outcomes and predictors for poor treatment outcomes for tuberculosis (TB) among native- and foreign-born patients with drug-susceptible TB (DSTB) in the Netherlands. METHODS: This retrospective cohort study included adult patients with DSTB treated from 2005 to 2015 from a nationwide exhaustive registry. Predictors for unsuccessful treatment outcomes (default and failure) and TB-associated mortality were analysed using multivariate logistic regression...
October 22, 2018: Clinical Microbiology and Infection
S Karakonstantis
No abstract text is available yet for this article.
October 16, 2018: Clinical Microbiology and Infection
Amihai Rottenstreich, Shmuel Benenson, Gabriel Levin, Geffen Kleinstern, Allon E Moses, Sharon Amit
OBJECTIVES: To investigate the incidence, risk factors, clinical course and outcomes of pregnancy-related group A streptococcus (GAS) infection. METHODS: A retrospective 13-year cohort study of culture-proven pregnancy-related GAS infection was performed at two university hospitals, serving heterogeneous, multicultural, urban and rural populations. RESULTS: Of 124 women diagnosed with pregnancy-related GAS infection, 115 (93%) were in the puerperium, an incidence of 0...
October 15, 2018: Clinical Microbiology and Infection
Jan Tkadlec, Monika Peckova, Lucie Sramkova, Vilem Rohn, David Jahoda, Dominik Raszka, Jan Berousek, Frantisek Mosna, Tomas Vymazal, Milan Kvapil, Pavel Drevinek
OBJECTIVES: Broad-range PCR has the potential to detect virtually any bacterial species via amplification and nucleotide sequencing of a DNA region common to all bacteria. We aimed to evaluate its usefulness and clinical relevance when applied to a wide variety of primary sterile materials. METHODS: A prospective study including 1370 samples (75 heart valves, 151 joint tissue samples, 230 joint aspirates, 848 whole blood samples and 66 culture negative cerebrospinal fluid samples) were studied by using a commercial PCR system for detecting 16S rDNA (Molzym)...
October 12, 2018: Clinical Microbiology and Infection
C Adembri, T Cai, A Novelli
No abstract text is available yet for this article.
October 11, 2018: Clinical Microbiology and Infection
T Kotar, M Pirš, A Steyer, T Cerar, B Šoba, M Skvarc, M Poljšak Prijatelj, T Lejko Zupanc
OBJECTIVES: A stool sample is the sample of choice for microbiological testing of enteric pathogens causing diarrhoea, but a rectal swab can be a more practical alternative. A prospective observational study was performed to evaluate the diagnostic performance of flocked rectal swab specimens using the syndromic molecular approach to determine the aetiology of diarrhoea in adults. METHODS: We compared the performance of rectal swabs with stool samples as the reference standard in determining viral, bacterial and protozoal pathogens using real-time multiplex PCR as well as standard stool culture...
October 11, 2018: Clinical Microbiology and Infection
L Tomasoni, G Messina, F Genco, L Scudeller, M Prestia, V Spinoni, C Bonfanti, F Prefumo, F Castelli, V Meroni
OBJECTIVES: Congenital toxoplasmosis (CT) affects 1-10 fetuses/10,000 live newborns in western countries. Without knowing pre-conception serostatus, it is hard to date the infection when anti-Toxoplasma IgG and IgM antibodies are positive at first screening. While a high IgG avidity index (AI) in the first trimester excludes CT, the same cannot be said of intermediate and low AI. The aim of this study was to estimate the risk of CT when intermediate or low AI is detected in the first trimester of pregnancy...
October 10, 2018: Clinical Microbiology and Infection
Dennis Nurjadi, Ralf Fleck, Andreas Lindner, Johannes Schäfer, Maximilian Gertler, Andreas Mueller, Heimo Lagler, Perry Jj Van Genderen, Eric Caumes, Sébastien Boutin, Esther Kuenzli, Joaquim Gascon, Anu Kantele, Martin P Grobusch, Klaus Heeg, Philipp Zanger
OBJECTIVES: Recently, following import by travel and migration, epidemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has caused nosocomial outbreaks in Europe, sometimes with a fatal outcome. We describe clinico-epidemiological characteristics of CA-MRSA detected by the European Network for the Surveillance of imported S. aureus (www. from May 2011- November 2016. METHODS: Sentinel surveillance at thirteen travel-clinics enrolling patients with travel-associated skin and soft tissue infection (SSTI) and analysing lesion and nose swabs at one central laboratory...
October 10, 2018: Clinical Microbiology and Infection
M Stecher, A Chaillon, A M Eis-Hübinger, C Lehmann, G Fätkenheuer, J-C Wasmuth, E Knops, J J Vehreschild, S Mehta, M Hoenigl
OBJECTIVES: In Germany, previous reports have demonstrated transmitted human immunodeficiency virus type 1 (HIV-1) drug-resistance mutations (DRM) in 11% of newly diagnosed individuals, highlighting the importance of drug-resistance screening before the initiation of antiretroviral therapy (ART). Here, we sought to understand the molecular epidemiology of HIV DRM transmission in the Cologne-Bonn region of Germany, given one of the highest rates of new HIV diagnoses in western Europe (13...
October 10, 2018: Clinical Microbiology and Infection
A Molina-Ortega, C Martín-Gandul, J D Mena-Romo, M J Rodríguez-Hernández, M Suñer, C Bernal, M Sánchez, J Sánchez-Céspedes, P Pérez Romero, E Cordero
INTRODUCTION: Although solid organ transplant (SOT) recipients with pretransplant serology for cytomegalovirus (CMV-R+) are considered at intermediate risk for CMV infection post transplantation, CMV infection remains a major cause of morbidity in this population. We prospectively characterized whether having pretransplant CMV-specific cellular immunity is independently associated with controlling infection after transplantation in R + SOT recipients. METHODS: A prospective cohort of consecutive R + SOT recipients that received pre-emptive treatment for CMV infection was monitored after transplantation and variables were recorded during the follow-up...
October 5, 2018: Clinical Microbiology and Infection
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