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Clinical Microbiology and Infection

S Siméon, E Flécher, M Revest, M Niculescu, J-C Roussel, M Michel, P Leprince, P Tattevin
OBJECTIVES: Implantable left ventricular assist device (LVAD) is a major therapeutic progress for end-stage heart failure in selected patients. As their use is expanding, infectious complications are emerging, with limited data available to guide their management. We aimed to better characterize LVAD-related infections. METHODS: We enrolled all consecutive patients diagnosed with LVAD-related infections in 3 referral centers in France, using standardized definition of infections in patients with LVAD...
March 18, 2017: Clinical Microbiology and Infection
H Tissot-Dupont, J P Casalta, F Gouriet, S Hubert, E Salaun, G Habib, M P Fernandez-Gerlinger, J L Mainardi, P Tattevin, M Revest, F Lucht, E Botelho-Nevers, A Gagneux-Brunon, U Snygg-Martin, K L Chan, J Bishara, I Vilacosta, C Olmos, J A San Román, J López, P Tornos, N Fernández-Hidalgo, E Durante-Mangoni, R Utili, M Paul, L M Baddour, D C De Simone, M R Sohail, J M Steckelberg, W R Wilson, D Raoult
OBJECTIVE: The management of infective endocarditis (IE) may differ from international guidelines, even in reference centers. This is probably due to the fact that most recommendations are not based on hard evidence, so that the consensus obtained for the guidelines does not represent actual practices. For this reason, we aimed at evaluating this question in the particular field of antibiotic therapy. METHODS: Thirteen international centers specialized in the management of IE were selected, according to their reputation, clinical results, original research publications and quotations...
March 18, 2017: Clinical Microbiology and Infection
Mario Rodríguez-Domínguez, José María González-Alba, Teresa Puerta, Laura Martínez-García, Blanca Menéndez, Rafael Cantón, Jorge Del Romero, Juan Carlos Galán
OBJECTIVES: Sexually transmitted infections are frequently related to outbreaks in high-risk populations due to the dense sexual networks. We wanted to determine the dissemination of a C. trachomatis variant characterized by pmpH-recombinant gene between L and G genotypes, which was previously described in a high-risk population. METHODS: 449 samples were analysed in two periods ranging from 2009-2015 for detection of pmpH-recombinant gene. For those samples yielding positive amplification, a sampling was selected for phylogenetic reconstructions based on sequencing of five chromosomal genes...
March 18, 2017: Clinical Microbiology and Infection
Sara de Menezes, Olivia Smibert
No abstract text is available yet for this article.
March 15, 2017: Clinical Microbiology and Infection
Diem-Lan Vu, Laurent Kaiser
No abstract text is available yet for this article.
March 10, 2017: Clinical Microbiology and Infection
Siamak Sabour
Kappa value is not the most appropriate test in reliability analysis for qualitative outcomes. Two important weaknesses of k statistics to assess agreement are as follow: the prevalence in each category can dramatically change kappa value which means it can be possible to have different kappa value having the same percentage for both concordant and discordant cells! Kappa value also depends upon the number of categories. Therefore, to avoid misleading messages, using weighted kappa can be suggested as a correct statistical test...
March 10, 2017: Clinical Microbiology and Infection
Mar Riveiro-Barciela, Marta Bes, Francisco Rodríguez-Frías, David Tabernero, Alicia Ruiz, Rosario Casillas, Judith Vidal, Maria Homs, Leonardo Nieto, Silvia Sauleda, Rafael Esteban, Maria Buti
OBJECTIVES: to investigate whether hepatitis B surface antigen (HBsAg) and hepatitis B core-related antigen (HBcrAg) levels are useful to identify inactive carriers among HBeAg-negative patients infected by different HBV genotypes. METHODS: 202 consecutive HBeAg-negative chronic hepatitis B patients, 135 inactive carriers and 67 with HBV activity, were prospectively followed during 1 year. RESULTS: In HBeAg-negative patients, HBsAg levels differed across the different genotypes (p<0...
March 10, 2017: Clinical Microbiology and Infection
Meintje Doting, Jan Weel, H Niesters, A Riezebos-Brilman, Afke Brandenburg
OBJECTIVES: Hepatitis E virus (HEV) genotype 3 is endemic in Europe and an underdiagnosed and emerging (public) health issue. In recent years commercial enzyme immunoassays (EIAs) that detect antibodies to HEV more adequately, became available. We investigated the added value of this HEV serology in the diagnostic work flow to detect viral causes of recent hepatitis. METHODS: During a two year period (May 2013 - May 2015), HEV serology was added to the hepatitis work flow, consisting of serological detection of hepatitis A-B-C virus (HAV, HBV, HCV), Epstein-Barr Virus (EBV) and Cytomegalovirus (CMV)...
March 7, 2017: Clinical Microbiology and Infection
Didier Raoult
No abstract text is available yet for this article.
March 7, 2017: Clinical Microbiology and Infection
N Singh, V Manchanda
No abstract text is available yet for this article.
March 6, 2017: Clinical Microbiology and Infection
Nubwa Medugu, Kenneth C Iregbu, Robert E Parker, Jessica Plemmons, Pallavi Singh, Lamidi I Audu, Efena Efetie, H Dele Davies, Shannon D Manning
OBJECTIVES: Because few studies have been conducted on group B Streptococcus (GBS) in Nigeria, we sought to estimate GBS colonization and transmission frequencies for 500 women and their newborns and identify risk factors for both outcomes. METHODS: GBS strains were characterized for antibiotic susceptibilities, capsule (cps) genotype, pilus island profile, and multilocus sequence type (ST). RESULTS: In all, 171 (34.2%) mothers and 95 (19...
March 5, 2017: Clinical Microbiology and Infection
L Leibovici
No abstract text is available yet for this article.
March 5, 2017: Clinical Microbiology and Infection
Joshua S Davis, Carol Mackrow, Paula Binks, Wendy Fletcher, Pascale Dettwiller, Catherine Marshall, Jane Day, William Pratt, Steven Yc Tong
OBJECTIVES: Cellulitis is a common skin infection resulting in inflammation that may take weeks to resolve despite appropriate antibiotics. It is unclear whether the adjunctive use of non-steroidal anti-inflammatory drugs hastens the resolution of inflammation in patients with cellulitis. METHODS: We conducted a double-blind, randomised controlled trial comparing ibuprofen 400mg three times daily for five days with identical placebo in adults with uncomplicated cellulitis of the upper or lower limb who were treated with intravenous cefazolin via an outpatient parenteral antibiotic treatment service at one of two Australian hospitals...
March 5, 2017: Clinical Microbiology and Infection
Iiro H Jääskeläinen, Lars Hagberg, Erik Forsblom, Asko Järvinen
OBJECTIVES: Factors associated with the time to clinical stability in patients with complicated skin and skin structure infection (cSSSI) were analysed in a retrospective population-based study. METHODS: All hospitalized patients (n=402) with cSSSI in two Nordic cities during a 4 year period were included. Patient, disease and treatment related factors were analysed in relation to early (0-3 days) or late (≥ 4 days) clinical stability. Clinical stability was assessed as improvement of infection related local and systemic signs...
March 5, 2017: Clinical Microbiology and Infection
Bruno François, Olivier Barraud, Hasan S Jafri
No abstract text is available yet for this article.
March 5, 2017: Clinical Microbiology and Infection
Grégory Dubourg, Florent Cornu, Sophie Edouard, Alexandre Battaini, Michel Tsimaratos, Didier Raoult
No abstract text is available yet for this article.
March 5, 2017: Clinical Microbiology and Infection
Timothy M Rawson, Luke Sp Moore, Bernard Hernandez, Esmita Charani, Enrique Castro-Sanchez, Pau Herrero, Benedict Hayhoe, William Hope, Pantelis Georgiou, Alison H Holmes
OBJECTIVES: Clinical decision support systems (CDSS) for antimicrobial management can support clinicians to optimise antimicrobial therapy. We reviewed all original literature (qualitative and quantitative) to understand the current scope of CDSS for antimicrobial management and analyse existing methods used to evaluate and report such systems. METHOD: PRISMA guidelines were followed. Medline, EMBASE, HMIC Health and Management, and Global Health databases were searched from 1(st) January 1980 to 31(st) October 2015...
March 4, 2017: Clinical Microbiology and Infection
Carolina Garcia-Vidal, Irene Sanchez-Rodriguez, Antonella Francesca Simonetti, Joaquín Burgos, Diego Viasus, Maria Teresa Martin, Vicenç Falco, Jordi Carratalà
OBJECTIVES: Concerns have arisen regarding the equivalence of levofloxacin and some macrolides for treating community-acquired legionella pneumonia (LP). We aimed to compare the outcomes of current patients with LP treated with levofloxacin, azithromycin and clarithromycin. METHODS: Observational retrospective multicenter study of consecutive patients with LP requiring hospitalization (2000-2014) conducted in two hospitals. The primary outcome assessed was 30-day mortality...
March 3, 2017: Clinical Microbiology and Infection
Catherine J Byrne, Jason A Roberts, Brett McWhinney, Sheila A Ryder, Jerome P Fennell, Philomena O'Byrne, Evelyn Deasy, Sean Egan, Ronan Desmond, Helen Enright, Deirdre M D'Arcy, Johnny McHugh
OBJECTIVES: To describe the population pharmacokinetics of teicoplanin in adult haematological malignancy patients receiving higher than standard doses and to perform Monte Carlo simulations to determine dosing regimens associated with optimal teicoplanin concentrations. METHODS: This was a hospital-based clinical trial (EudraCT 2013-004535-72). Nine blood samples were collected on Day 3, plus single trough samples on Days 7 and 10, and 24 and 48 h post last dose...
March 3, 2017: Clinical Microbiology and Infection
Giulia Martelli, Chiara Di Girolamo, Lorenzo Zammarchi, Andrea Angheben, Matteo Morandi, Stefano Tais, Monica Degani, Issa El Hamad, Silvio Caligaris, Anna Ciannameo, Elisabetta Grilli, Lucia Urbinati, Geraldo Badona Monteiro, Carmelo Scarcella, Nicola Petrosillo, Margherita Digaetano, Lorenzo Rabbi, Noemi Bazzanini, Francesca Cacciatore, Brigida Lilia Marta, Maria Luisa Moro, Alessandro Bartoloni, Pierluigi Viale, Gabriella Verucchi
OBJECTIVE: This multicentre cross-sectional study aims to estimate the prevalence of five neglected tropical diseases (Chagas disease, filariasis, schistosomiasis, strongyloidiasis, toxocariasis) among immigrants accessing health care facilities in five Italian cities (Bologna, Brescia, Florence, Rome, Verona). METHODS: Individuals underwent a different set of serological tests, according to country of origin and presence of eosinophilia. Seropositive patients were treated and further followed up...
March 1, 2017: Clinical Microbiology and Infection
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