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Clinical Microbiology and Infection

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https://www.readbyqxmd.com/read/29787890/invasive-mold-disease-in-hematologic-patients-comparison-between-fusariosis-and-aspergillosis
#1
Fabio Nucci, Simone A Nouér, Domenico Capone, Marcio Nucci
OBJECTIVES: To compare the epidemiology, clinical presentation, diagnosis, treatment and outcome of hematologic patients with invasive aspergillosis (IA) or invasive fusariosis (IF). METHODS: We retrospectively reviewed the charts of 36 patients with IA and 26 with IF diagnosed between 2006 and 2017 in hematologic patients, and compared baseline characteristics, coexisting exposures, clinical manifestations, treatment and the outcome. RESULTS: Fever was more frequent in IF (96...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29787889/diagnosis-of-bloodstream-infections-from-positive-blood-cultures-and-directly-from-blood-samples-recent-developments-in-molecular-approaches
#2
REVIEW
Nilay Peker, Natacha Couto, Bhanu Sinha, John W Rossen
BACKGROUND: Bloodstream infections are a major cause of death with increasing incidence and severity. Blood cultures are still the gold standard for microbiological diagnosis, but are rather slow. Molecular methods can be used as add-on complementary assays. They can be useful to speed up microbial identification and to predict antimicrobial susceptibility, applied to direct blood samples or positive blood cultures. AIM: To review recent developments in molecular based diagnostic platforms used for the identification of bloodstream infections, with a focus on assays performed directly on blood samples and positive blood cultures...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29787888/understanding-the-microbiome-of-diabetic-foot-osteomyelitis-insights-from-molecular-and-microscopic-approaches
#3
Khalid Johani, Blain G Fritz, T Bjarnsholt, Benjamin A Lipsky, Slade O Jensen, Mark Yang, Anastasia Dean, H Hu, Karen Vickery, Matthew Malone
OBJECTIVES: Rigorous visual evidence on whether or not biofilms are involved in diabetic foot osteomyelitis (DFO) is lacking. We employed a suite of molecular and microscopic approaches to investigate the microbiome, and phenotypic state of microorganisms involved in DFO. METHODS: In 20 consecutive subjects with suspected DFO, we collected intraoperative bone specimens. To explore the microbial diversity present in infected bone we performed next-generation DNA sequencing...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29787887/human-pegivirus-persistence-in-the-human-blood-virome-after-allogeneic-haematopoietic-stem-cell-transplantation
#4
Diem-Lan Vu, Samuel Cordey, Federico Simonetta, Francisco Brito, Mylène Docquier, Lara Turin, Christian van Delden, Elsa Boely, Carole Dantin, Amandine Pradier, Eddy Roosnek, Yves Chalandon, Evgeny M Zdobnov, Stavroula Masouridi-Levrat, Laurent Kaiser
OBJECTIVES: As commensal viruses are defined by the immunological tolerance afforded to them, any immunomodulation, such as is received during haematopoietic stem cell transplantation, may shift the demarcation between innocuous viral resident and disease-causing pathogen. METHODS: We analysed by deep-sequencing the plasma virome of 40 allogeneic haematopoietic stem cell transplant (allo-HSCT) patients 1 month post-transplantation. As human pegivirus (HPgV) was highly prevalent, we performed a one-year screening of 122 plasma samples by specific rRT-PCR assay...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29787886/monomicrobial-klebsiella-pneumoniae-necrotizing-fasciitis-an-emerging-life-threatening-entity
#5
REVIEW
G R Rahim, Neha Gupta, Puneet Maheshwari, M P Singh
BACKGROUND AND AIMS: Necrotizing fasciitis (NF) although rare, is a potentially fatal infection. Majority of cases being polymicrobial; a recent surge in monomicrobial NF caused by Klebsiella pneumoniae (KP-NF) has been reported. KP-NF recently accounted for an average of 16% amongst all pathogens with highest mortality rate of 60%. This review discusses the important aspects of KP-NF with additional note on implications of multidrug resistant infections. SOURCES: Literature was searched using PubMed...
May 19, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29783026/a-prolonged-and-large-outbreak-of-invasive-group-a-streptococcal-disease-within-a-nursing-home-repeated-intra-facility-transmission-of-a-single-strain
#6
S A Nanduri, B J Metcalf, M A Arwady, C Edens, M A Lavin, J Morgan, W Clegg, A Beron, J P Albertson, R Link-Gelles, A Ogundimu, J Gold, D Jackson, S Chochua, N Stone, C Van Beneden, K Fleming-Dutra, B Beall
OBJECTIVES: Multiple invasive group A streptococcal (GAS) infections were reported to public health by a skilled nursing facility (Facility A) in Illinois between May 2014 and August 2016. Cases continued despite interventions including antibiotic prophylaxis for all residents and staff. Two other geographically close facilities reported contemporaneous outbreaks of GAS. We investigated potential reasons for ongoing transmission. METHODS: We obtained epidemiologic data from chart review of cases and review of facility and public health records from previous investigations into the outbreak...
May 18, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29783025/immunogenicity-and-reactogenicity-of-high-versus-standard-dose-trivalent-inactivated-influenza-vaccine-in-healthcare-workers-a-pilot-randomized-controlled-trial
#7
C Volling, B L Coleman, K Katz, A E Simor, M Muller, J Powis, J McElhaney, A McGeer
OBJECTIVES: To compare immunogenicity, reactogenicity and acceptability of high- and standard-dose trivalent inactivated influenza vaccine (HDTIV, SDTIV) in 18-64 year olds. METHODS: We randomized 18-64-year-olds to HDTIV or SDTIV in two consecutive years. We collected serum on Days 0 and 21, measured hemagglutination inhibition (HAI) titers, and compared seroconversion, Day 21 titers, seroprotection, reactogenicity, acceptability. RESULTS: Immunogenicity was evaluable in 42 of 47 2014 participants, all 33 both year participants, and 87 of 90 2015-only participants...
May 18, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777927/patient-related-determinants-of-antibiotic-use-a-systematic-review
#8
REVIEW
V Zanichelli, G Tebano, I C Gyssens, V Vlahović-Palčevski, A A Monnier, M Stanic Benic, S Harbarth, M Hulscher, C Pulcini, B D Huttner
OBJECTIVES: We aimed to assess patient-related determinants potentially influencing antibiotic use. METHODS: Studies published in MEDLINE until 30/09/2015 were searched. We included: (1) qualitative studies describing patients' self-reported determinants of antibiotic use; (2) quantitative studies on either self-reported or objectively assessed determinants associated with antibiotic use. Whenever possible, reported determinants were categorized as "barriers" or "facilitators" of responsible antibiotic use...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#9
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777925/epidemiology-of-respiratory-pathogen-carriage-in-the-homeless-population-within-2-shelters-in-marseille-france-2015-2017-cross-sectional-one-day-surveys
#10
Tran Duc Anh Ly, Sophie Edouard, Sekene Badiaga, Herve Tissot-Dupont, Van Thuan Hoang, Vincent Pommier de Santi, Philippe Brouqui, Didier Raoult, Philippe Gautret
OBJECTIVES: To assess risk factors for respiratory tract infection symptoms and signs in sheltered homeless people in Marseille during the winter season, including pathogen carriage. METHODS: Data on 479 male participants within 2 shelters who completed questionnaires and a total of 950 nasal and pharyngeal samples were collected during the winters of 2015-2017. Respiratory pathogen carriage including 7 viruses and 4 bacteria was assessed by quantitative polymerase chain reaction...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777924/views-and-experiences-with-regard-to-antibiotic-use-of-hospitalised-patients-in-five-european-countries-a-qualitative-descriptive-study
#11
V Zanichelli, A A Monnier, G Tebano, M Stanić Benić, I C Gyssens, C Pulcini, V Vlahović-Palčevski, M Schindler, S Harbarth, M Hulscher, B D Huttner
OBJECTIVES: To explore inpatients experiences and views with regard to antibiotics in 5 European hospitals. METHODS: Qualitative study where a patient-centred framework was used to explore inpatients' experiences concerning antibiotic treatment. A purposeful sample of inpatients treated with antibiotics in 5 hospitals (Belgium-BE, Croatia-HR, France-FR, Netherlands-NL, Switzerland-CH) participated in interviews (all centres) and focus groups (CH). RESULTS: 31 interviews (BE=5, HR=10, F=9, NL=5, CH=2) and three focus groups (CH= 11 participants) were performed...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29777923/diagnosis-and-management-of-pulmonary-infection-due-to-rhodococcus-equi
#12
REVIEW
Weijie V Lin, Robert L Kruse, Katharine Yang, Daniel M Musher
BACKGROUND: Rhodococcus equi is a recognized cause of disease in humans, especially in patients who are immunocompromised. Because diphtheroids are regarded as part of normal respiratory flora, the importance of R. equi as a pulmonary pathogen may not be fully appreciated and its prevalence underestimated. Most treatment recommendations for R. equi infection were established before antiretroviral drugs became available for HIV/AIDS therapy, and therapeutic strategies may need to be updated...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29730224/rapid-diagnosis-of-parasitic-diseases-current-scenario-and-future-needs
#13
REVIEW
Stefan Momčilović, Cinzia Cantacessi, Valentina Arsić-Arsenijević, Domenico Otranto, Suzana Tasić-Otašević
BACKGROUND: Parasitic diseases are one of the world's most devastating and prevalent infections which cause millions of morbidities and mortalities annually. In the past, many of these infections have been linked predominantly to tropical or subtropical areas. Nowadays, however, climatic and vector ecology changes, a significant increase in international travel, armed conflicts and migration of humans and animals have influenced the transmission of some parasitic diseases from "book pages" to reality in developed countries...
May 3, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29730223/commentary-practical-considerations-to-implement-the-shorter-regimen-to-mdr-tb-patients-in-china
#14
Qihui Liu, Feng Sun, Yang Li, Jing Bao, Ying Zhang, Wenhong Zhang
No abstract text is available yet for this article.
May 3, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29730222/accuracy-of-qpcr-for-quantifying-leishmania-kdna-in-different-skin-layers-of-patients-with-american-tegumentary-leishmaniasis
#15
Lais Sevilha-Santos, de Castro Moreira Dos Santos Júnior Agenor, Silva Viviane Medeiros, Bergmann Jaqueline Osiro, da Silva Eduardo Freitas, Segato Larissa Freire, Arabi Arthur Youssif Mota, de Paula Natália Aparecida, Ribeiro Sampaio Raimunda Nonata, Dolabela de Lima Beatriz, Gomes Ciro Martins
OBJECTIVES: Superficial swab sampling of American tegumentary leishmaniasis (ATL) lesions shows higher amounts of Leishmania than those from biopsy. Subcutaneous involvement is also important in ATL, but parasite quantification according to lesion depth has not been evaluated. We aim to present the best depth at which sampling should be performed for molecular exams of ATL. METHODS: Patients with a clinical presentation compatible with ATL were allocated to ATL and control groups...
May 3, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29729331/the-vaginal-microbiota-and-its-association-with-human-papillomavirus-chlamydia-trachomatis-neisseria-gonorrhea-and-mycoplasma-genitalium-infections-a-systematic-review-and-meta-analysis
#16
REVIEW
Jeanne Tamarelle, Anne C M Thiébaut, Bertille de Barbeyrac, Cécile Bébéar, Jacques Ravel, Elisabeth Delarocque-Astagneau
OBJECTIVES: The vaginal microbiota may modulate susceptibility to Human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhea and Mycoplasma genitalium infections. The objective of this meta-analysis was to evaluate the association between these infections and the vaginal microbiota. METHODS: The search (2000-2016) yielded 1054 articles, of which 39 articles meeting the inclusion criteria were analyzed. The vaginal microbiota was dichotomized into high-Lactobacillus vaginal microbiota (HL-VMB) and low-Lactobacillus vaginal microbiota (LL-VMB), using either Nugent score, Amsel's criteria, presence of clue cells or gene sequencing...
May 2, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29723571/pharmacokinetics-of-colistin-in-an-8-years-old-child-with-an-acute-bone-infection
#17
LETTER
Sophie Magréault, Caroline Petyt, Eric Senneville, Damien Fron, Eric Nectoux, Caroline Loiez, Sandrine Marchand, Nicolas Grégoire, William Couet
No abstract text is available yet for this article.
April 30, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29723570/investigation-of-trimethoprim-sulfamethoxazole-resistance-in-an-emerging-sequence-type-5-methicillin-resistant-staphylococcus-aureus-clone-reveals-discrepant-resistance-reporting
#18
LETTER
T M Harris, A C Bowen, D C Holt, D S Sarovich, K Stevens, B J Currie, B P Howden, J R Carapetis, P M Giffard, S Y C Tong
No abstract text is available yet for this article.
April 30, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29715553/development-and-validation-of-baseline-perioperative-and-at-discharge-predictive-models-for-postsurgical-prosthetic-joint-infection
#19
María Dolores Del Toro, Cecilia Peñas, Ana Conde Albarracín, Julián Palomino, Francisco Brun, Santiago Sánchez, Jesús Rodríguez-Baño
OBJECTIVES: To develop and validate baseline, perioperative and at-discharge risk-scoring systems for postsurgical prosthetic joint infection (PJI) in patients undergoing arthroplasty. PATIENTS AND METHODS: A multicentre, prospective cohort study of patients undergoing hip and knee arthroplasty was performed. Patients were randomly assigned (2:1) to a derivation cohort (DC) or a validation cohort (VC). Multivariable predictive models of PJI were constructed at baseline (preoperative period), perioperative (adding perioperative variables), and at-discharge (adding wound state at-discharge)...
April 28, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29715552/monoclonal-antibodies-as-anti-infective-products-a-promising-future
#20
REVIEW
Eric Pelfrene, Manuela Mura, Ana Cavaleiro Sanches, Marco Cavaleri
BACKGROUND: The paucity of licensed monoclonal antibodies in the infectious diseases arena strongly contrasts with the ready availability of these therapeutics for use in other conditions. AIMS: This narrative review aims to assess the potential of monoclonal antibody-based interventions for infectious diseases. SOURCES: A review of the literature via the MEDLINE database was performed and complemented by published official documents on licensed anti-infective monoclonal antibodies...
April 28, 2018: Clinical Microbiology and Infection
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