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Clinical Microbiology and Infection

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https://www.readbyqxmd.com/read/28428122/challenges-in-the-management-of-chagas-disease-in-latin-american-migrants-in-europe
#1
REVIEW
B Monge-Maillo, R López-Vélez
 Chagas disease (CD) is endemic in Latin America. Due to migration, the infection has crossed borders and it is estimated that 68 000-120 000 people with CD are currently living in Europe and 30% of them may develop visceral involvement. However, up to 90% of CD cases in Europe remain undiagnosed. The challenges which have to be overcome in CD are related to screening, diagnostic tools and therapeutic management in non-endemic countries. AIMS : The aim of this review is to highlight how healthcare management for Latin American migrants with CD in Europe may be improved...
April 17, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412384/molecular-epidemiology-of-penicillinase-producing-neisseria-gonorrhoeae-isolates-in-france
#2
Maité Micaëlo, Agathe Goubard, Guy La Ruche, Erick Denamur, Olivier Tenaillon, Emmanuelle Cambau, Hervé Jacquier, Béatrice Bercot
OBJECTIVES: Characterising the molecular epidemiology of antibiotic resistance is crucial for a better understanding of the evolution and spread of resistance in Neisseria gonorrhoeae. Here, we examine the molecular epidemiology of penicillinase-producing N. gonorrhoeae (PPNG) isolates in France. METHODS: We investigated 176 PPNG isolates collected between 2010 and 2012 by the National Reference Centre in France. Genotyping was performed using the NG-MAST technique, blaTEM genes were Sanger-sequenced, and plasmids were characterized by PCR-typing...
April 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412383/a-prospective-international-aspergillus-terreus-survey-an-efisg-isham-and-ecmm-joint-study
#3
Brigitte Risslegger, Tamara Zoran, Michaela Lackner, Maria Aigner, Ferran Sánchez-Reus, Antonio Rezusta, Anuradha Chowdhary, Saad Jaber Taj-Aldeen, Maiken C Arendrup, Salvatore Oliveri, Dimitrios P Kontoyiannis, Ana Alastruey-Izquierdo, Katrien Lagrou, Giuliana Lo Cascio, Jacques F Meis, Walter Buzina, Claudio Farina, Miranda Drogari-Apiranthitou, Anna Grancini, Anna Maria Tortorano, Birgit Willinger, Axel Hamprecht, Elizabeth Johnson, Lena Klingspor, Valentina Arsic-Arsenijevic, Oliver A Cornely, Joseph Meletiadis, Wolfgang Prammer, Vivian Tullio, Jörg-Janne Vehreschild, Laura Trovato, Russell E Lewis, Esther Segal, Peter-Michael Rath, Petr Hamal, Manuel Rodriguez-Iglesias, Emmanuel Roilides, Sevtap Arikan-Akdagli, Arunaloke Chakrabarti, Arnaldo L Colombo, Mariana S Fernández, M Teresa Martin-Gomez, Hamid Badali, Georgios Petrikkos, Nikolai Klimko, Sebastian M Heimann, Jos Houbraken, Omrum Uzun, Michael Edlinger, Sonia de la Fuente, Cornelia Lass-Flörl
OBJECTIVES: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B (AMB) susceptibility of Aspergillus terreus species complex infections. METHODS: Three hundred seventy cases from 21 countries were evaluated. RESULTS: The overall prevalence of A. terreus species complex among patients investigated and with mold positive cultures was 5.2% (370/7116). AMB MICs were ranging from 0...
April 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412382/use-of-nebulized-antimicrobials-for-the-treatment-of-respiratory-infections-in-invasively-mechanically-ventilated-adults-a-position-paper-from-the-european-society-of-clinical-microbiology-and-infectious-diseases
#4
Jordi Rello, Candela Solé-Lleonart, Jean-Jacques Rouby, Jean Chastre, Stijn Blot, Garyfallia Poulakou, Charles-Edouard Luyt, Jordi Riera, Lucy B Palmer, Jose M Pereira, Tim Felton, Jayesh Dhanani, Matteo Bassetti, Tobias Welte, Jason A Roberts
With an established role in cystic fibrosis and bronchiectasis, nebulized antibiotics are increasingly being used to treat respiratory infections in critically ill invasively mechanically ventilated adult patients. Although there is limited evidence describing their efficacy and safety, in an era of need for new strategies to enhance antibiotic effectiveness because of a shortage of new agents and increases in antibiotic resistance, the potential of nebulization of antibiotics to optimize therapy is considered of high interest, particularly in patients infected with multidrug-resistant (MDR) pathogens...
April 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412379/challenges-of-measles-and-rubella-laboratory-diagnostic-in-the-era-of-elimination
#5
REVIEW
Judith M Hübschen, Sonja M Bork, Kevin E Brown, Annette Mankertz, Sabine Santibanez, Myriam Ben Mamou, Mick N Mulders, Claude P Muller
The Member States of the WHO European Region adopted the goal of measles and rubella elimination more than 10 years ago, but so far only 21 of 53 countries have reached this target. Laboratory investigation of suspected cases is essential to support disease elimination efforts. Therefore WHO maintains a network of accredited laboratories providing high quality testing AIMS.: The present article reviews current measles and rubella laboratory diagnostic methods and describes specific challenges in elimination settings SOURCES...
April 13, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412385/eliminating-measles-and-rubella-in-europe
#6
EDITORIAL
F Allerberger
No abstract text is available yet for this article.
April 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412381/optimal-efficacy-of-interferon-free-hcv-retreatment-after-protease-inhibitors-failure-in-real-life
#7
Valeria Cento, Silvia Barbaliscia, Ilaria Lenci, Tina Ruggiero, Carlo Federico Magni, Stefania Paolucci, Sergio Babudieri, Massimo Siciliano, Caterina Pasquazzi, Alessia Ciancio, Carlo Federico Perno, Francesca Ceccherini-Silberstein
OBJECTIVES: First-generation protease-inhibitors (PIs) had suboptimal efficacy in GT-1 patients with advanced liver disease, and those who failed may need urgent retreatment. Our objective was to analyze the real-life efficacy of interferon (IFN)-free retreatment after PI-failure, and the role of genotypic-resistance-testing (GRT) in guiding retreatment choice. METHODS: In this multi-center observational study, patients retreated with IFN-free regimens after first-generation PI-failure (telaprevir-boceprevir-simeprevir) were included...
April 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412380/colonization-by-multidrug-resistant-organisms-in-long-term-care-facilities-in-italy-a-point-prevalence-study
#8
Maria Giufrè, Enrico Ricchizzi, Marisa Accogli, Fabrizio Barbanti, Monica Monaco, Fernanda Pimentel de Araujo, Claudio Farina, Paolo Fazii, Romano Mattei, Mario Sarti, Agostino Barozzi, Rossella Buttazzi, Marina Cosentino, Maria Nardone, Vincenzo Savini, Patrizia Spigaglia, Annalisa Pantosti, Maria Luisa Moro, Marina Cerquetti
OBJECTIVES: This study aimed to determine prevalence and risk factors for colonization by multidrug-resistant organisms (MDROs) in long-term care facility (LTCF) residents in Italy. Genotypes of MDRO isolates were investigated. METHODS: A point-prevalence study was conducted at 12 LTCFs located in 4 Italian cities (2 February-14 March 2015). Rectal swabs, faeces and nasal/auxiliary swabs were cultured for extended-spectrum β-lactamase (ESBL)- and/or carbapenemase-producing Enterobacteriaceae, Clostridium difficile and methicillin-resistant Staphylococcus aureus (MRSA), respectively...
April 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28412378/project-management-importance-for-diagnostic-laboratories
#9
REVIEW
Antony Croxatto, Gilbert Greub
BACKGROUND: The constraints applied on diagnostic laboratories to improve both quality and productivity together with personal shortages incite laboratory managers to constantly optimize the laboratory workflows, organization and technology. These continuous modifications of the laboratories should be conducted using efficient project and change management approaches in order to maximize the opportunities to achieve the project successfully. AIM: This review aims at presenting a general overview of project management with an emphasis on selected critical aspects...
April 12, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28411185/detection-of-pyrazinamide-resistance-of-mycobacterium-tuberculosis-using-nicotinamide-as-a-surrogate
#10
Yanjie Hu, Xiaoguang Wu, Jingjing Luo, Yuhong Fu, Liping Zhao, Yifeng Ma, Yunxu Li, Qian Liang, Yuanyuan Shang, Hairong Huang
OBJECTIVES: Despite the importance of pyrazinamide (PZA) in tuberculosis treatment, PZA susceptibility testing is not routinely performed because of acid pH requirement. The aim of our assay was to evaluate the Microplate Alamar Blue assay (MABA) to detect resistance to PZA using nicotinamide (NIC) as a surrogate in neutral pH, and identify the appropriate cutoff point for the assay. METHODS: The NIC minimal inhibition concentrations (MICs) for 125 Mycobacterium tuberculosis clinical isolates were tested by MABA at nine different concentrations (from 8 to 2000μg/ml)...
April 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28411184/cmi-theme-issues-invitation-to-submit-papers
#11
EDITORIAL
L Leibovici, J Friedman
No abstract text is available yet for this article.
April 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28400339/albendazole-responsive-disseminated-tubulinosema-acridophagus-in-a-patient-with-chronic-lymphocytic-leukemia
#12
LETTER
William J Connors, Julie A Carson, Wilson W Chan, Michael D Parkins
No abstract text is available yet for this article.
April 8, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28400338/recommendations-for-aerosolized-antibiotics-in-vap-and-vat-too-little-and-too-late
#13
EDITORIAL
Marin H Kollef, Scott T Micek
No abstract text is available yet for this article.
April 8, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28396035/vancomycin-intermediate-staphylococcus-aureus-isolates-are-attenuated-for-virulence-when-compared-to-susceptible-progenitors
#14
David R Cameron, Ya-Hsun Lin, Sophie Trouillet-Assant, Virginie Tafani, Xenia Kostoulias, Effie Mouhtouris, Narelle Skinner, Kumar Visvanathan, Sarah L Baines, Brian Howden, Ian R Monk, Frederic Laurent, Timothy P Stinear, Benjamin P Howden, Anton Y Peleg
OBJECTIVES: Vancomycin-intermediate Staphylococcus aureus (VISA) is associated with genetic changes that may also impact upon pathogenicity. In the current study, we compared the virulence of clinical VISA strains with their isogenic vancomycin-susceptible progenitors (VSSA). METHODS: Production of the critical virulence protein, alpha toxin, was assessed using western blot analysis and was correlated to agr activity using a bioluminescent agr-reporter. Cytotoxicity and intracellular persistence was compared ex vivo for VSSA and VISA within non-professional phagocytes (NPP)...
April 7, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28389276/whole-genome-sequencing-of-shigella-sonnei-through-pulsenet-latin-america-and-caribbean-advancing-global-surveillance-of-foodborne-illnesses
#15
Kate Susan Baker, Josefina Campos, Mariana Pichel, Anabella Della Gaspera, Francisco Duarte-Martínez, Elena Campos-Chacón, Hilda María Bolaños-Acuña, Caterina Guzman-Verri, Alison E Mather, Susana Diaz Velasco, Maria Luz Zamudio Rojas, Jessica Forbester, Thomas Richard Connor, Karen Helena Keddy, Anthony Marius Smith, Enedia A Lopez de Delgado, Giovanny Angiolillo, Nirvia Cuaical, Jorge Fernandez, Carolina Aguayo, Melissa Morales Aguilar, Claudia Valenzuela, Ana Judith Morales Medrano, Alfredo Sirok Esteve, Natalie Weiler Gustafson, Paula Lucia Diaz Guevara, Lucy Angeline Montaño, Enrique Perez, Nicholas R Thomson
OBJECTIVE: Shigella sonnei is a globally-important diarrhoeal pathogen tracked through the surveillance network PulseNet Latin America and Caribbean (PNLA&C), which participates in PulseNet International. PNLA&C laboratories use common molecular techniques to track pathogens causing foodborne illness. We aimed to demonstrate the possibility and advantages of transitioning to whole genome sequencing (WGS) for surveillance within existing networks across a continent where S. sonnei is endemic...
April 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28377312/comparison-of-antipseudomonal-beta-lactams-for-febrile-neutropenia-empiric-therapy-systematic-review-and-network-meta-analysis
#16
REVIEW
Nobuyuki Horita, Yuji Shibata, Hiroki Watanabe, Ho Namkoong, Takeshi Kaneko
OBJECTIVES: Compare the effectiveness and safety of antipseudomonal beta-lactam empiric monotherapy for febrile neutropenia by network meta-analysis. METHODS: The searches using Pubmed, Cochrane CENTRAL, EMBASE, and Web of Science Core Collection were carried out in June 2016. English articles, non-English articles, full-length articles, short articles, and conference abstracts were allowed. Eligible trial design was a parallel-group individual randomization. We included febrile neutropenia adult and pediatric patients undergoing chemotherapy for either solid tumors or hematological malignanciesand treated with intravenous antipseudomonal beta-lactams for initial empiric therapy...
April 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28377311/new-approaches-for-antifungal-susceptibility-testing
#17
REVIEW
M Sanguinetti, B Posteraro
BACKGROUND: Invasive fungal diseases, including those caused by (multi)drug-resistant Candida and Aspergillus species, still represent global public health concerns. Information about the antifungal susceptibility testing (AFST) of fungal isolates must be quickly produced to help clinicians in administrating appropriate antifungal therapies. Unfortunately, reference AFST methods, albeit accurate, are labour-intensive and take several hours before patients' results can be available to the treating clinicians...
April 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28377310/risk-factors-for-extended-spectrum-beta-lactamase-producing-escherichia-coli-urinary-tract-infection-in-the-community-in-denmark-a-case-control-study
#18
Mette Søgaard, Uffe Heide-Jørgensen, Jan P Vandenbroucke, Henrik C Schønheyder, Christina Mje Vandenbroucke-Grauls
OBJECTIVE: To verify the role of proton pump inhibitors (PPI) and nitrofurantoin, which have appeared as novel risk factors for carriage of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, as risk factors for ESBL E.coli urinary tract infection (UTI). We included known risk factors to ascertain whether our findings are comparable with previous studies. METHODS: Population-based case-control study including 339 cases with community-onset ESBL E...
April 1, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28373148/evaluation-of-the-in-vitro-activity-of-isavuconazole-and-comparator-voriconazole-against-2635-contemporary-clinical-candida-and-aspergillus-isolates
#19
K M T Astvad, R K Hare, M C Arendrup
OBJECTIVE: The in vitro activity of isavuconazole was determined for 1677 Candida and 958 Aspergillus isolates from 2012-2014 with voriconazole as comparator. METHODS: Aspergillus isolates were screened for resistance using azole-agar. Screening positive Aspergillus and all Candida isolates underwent EUCAST broth-microdilution testing. Isolates were categorised as wild-type (wt) or non-wt, adopting EUCAST ECOFFs (where available) or wt upper limits (wtULs; two 2-fold dilutions above the MIC50)...
March 31, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28373147/vancomycin-treatment-is-a-risk-factor-for-vancomycin-nonsusceptible-staphylococcus-capitis-sepsis-in-preterm-neonates
#20
Marine Butin, Jean-Philippe Rasigade, Fabien Subtil, Patricia Martins-Simões, Charlotte Pralong, Anne-Marie Freydière, François Vandenesch, Sylvestre Tigaud, Jean-Charles Picaud, Frédéric Laurent
OBJECTIVE: Multiresistant, vancomycin-nonsusceptible Staphylococcus capitis is an emerging cause worldwide of late-onset sepsis (LOS) in preterm neonates. The pathophysiology and risk factors for S. capitis-related LOS are poorly understood but we hypothesized that S. capitis LOS follows translocation from the gut microbiota rather than catheter invasion. The objective of this study was to investigate the risk factors of S. capitis LOS and gut colonization. METHODS: We conducted a prospective monocentric cohort study of patients hospitalized in a tertiary care unit (Lyon, France) from June 2011 to January 2012...
March 31, 2017: Clinical Microbiology and Infection
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