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Clinical Microbiology and Infection

I Ferreira-González, N Fernández-Hidalgo, A Ribera
No abstract text is available yet for this article.
September 14, 2018: Clinical Microbiology and Infection
Y Peña-López, M Pujol, M Campins, L Lagunes, J Balcells, J Rello
No abstract text is available yet for this article.
September 11, 2018: Clinical Microbiology and Infection
Mazdak Badri, Bo Nilson, Sigurdur Ragnarsson, Erik Senneby, Magnus Rasmussen
OBJECTIVES: Gram-positive, anaerobic cocci (GPAC) can cause infections in humans. Only few cases of bacteremia with GPAC have been reported. We describe the clinical and microbiological characteristics of GPAC bacteremia. METHODS: A retrospective population-based study of GPAC bacteremia 2012-2016 in southern Sweden was performed. GPAC were identified using MALDI-TOF MS or 16S rRNA gene sequencing. Etests were used to determine antibiotic susceptibilities. Data on patient and infection characteristics, treatment, and outcome were collected from the medical records...
September 11, 2018: Clinical Microbiology and Infection
Magdalena Rzewuska, Esmita Charani, Janet E Clarkson, Peter G Davey, Eilidh M Duncan, Jill J Francis, Katie Gillies, Winfried V Kern, Fabiana Lorencatto, Charis A Marwick, Jo McEwen, Ralph Möhler, Andrew M Morris, Craig R Ramsay, Susan Rogers Van Katwyk, Brita Skodvin, Ingrid Smith, Kathryn N Suh, Jeremy M Grimshaw
SCOPE: Antibiotic stewardship programmes (ASPs) are necessary in hospitals to improve the judicious use of antibiotics. While ASPs require complex change of key behaviours on individual, team, organisation and policy levels, evidence from the behavioural sciences is underutilised in antibiotic stewardship studies across the world, including high-income countries (HICs). A consensus procedure was performed to propose research priority areas for optimising effective implementation of ASPs in hospital settings, using a behavioural perspective...
September 6, 2018: Clinical Microbiology and Infection
Fjeld Hilde, Stylianou Eva
Prolonged infusion dosing of beta-lactam antibiotics is being increasingly used in intensive care units in an attempt to optimise treatment. Betalactams are well known to have challenges regarding stability in solution. The degradation products from the narrow spectrum beta-lactam Penicillin G are suspected to increase hypersensitivity reactions. We are concerned that the subject is also relevant for more broad-spectrum beta-lactams. We highly recommend collaboration to find solutions on this important matter, instead of professionals one-by-one interpreting litterature...
September 6, 2018: Clinical Microbiology and Infection
Juan J Quereda, Irene M Rodríguez-Gómez, Jazmin Meza-Torres, Jaime Gómez-Laguna, Marie A Nahori, Olivier Dussurget, Librado Carrasco, Pascale Cossart, Javier Pizarro-Cerdá
OBJECTIVES: We investigated the contribution to virulence of the surface protein Internalin B (InlB) in the L. monocytogenes lineage I strain F2365, which caused in California in 1985 one of the deadliest listeriosis outbreaks. METHODS: The F2365 strain displays a point mutation that hampers expression of InlB. We rescued the expression of InlB in the L. monocytogenes lineage I strain F2365 introducing a point mutation in the codon 34 (TAA to CAA) and investigated its importance for bacterial virulence using in vitro cell infection systems and a murine intravenous infection model...
September 5, 2018: Clinical Microbiology and Infection
Emilie Javelle, Philippe Gautret, Didier Raoult
Yellow fever (YF) is an emerging expanding fatal arboviral disease that has been imported at least six times in Europe during the first half of 2018, while only seven travel-associated YF cases have been reported in the last 20 years, and none from Brazil. YF has a history of transmission in Europe which could become recurrent considering the wide globalization of competent vectors. This article argues that epidemiological current changes put Europe at risk of YF transmission. Risk assessment and strategies of control are required...
August 28, 2018: Clinical Microbiology and Infection
A Huttner
No abstract text is available yet for this article.
August 28, 2018: Clinical Microbiology and Infection
Ivanildo P Sousa Junior, Fernanda M Burlandy, Shirlene T S Lima, Ana C B Maximo, Maria A A Figueiredo, Zuinara Maia, Edson E da Silva
OBJECTIVES: To describe of an outbreak of acute myalgia accompanied by elevated levels of muscle enzymes occurred in the Northeast Region of Brazil from December 2016 through May 2017. METHODS: Clinical data were analyzed and laboratorial tests were performed in 86 specimens obtained from 52 suspected cases of acute myalgia. A Broader reactive enterovirus real time RT-PCR followed by a semi-nested PCR amplification of partial VP1 gene were performed to identify the causative agent...
August 24, 2018: Clinical Microbiology and Infection
Maciej Kołodziej, Hania Szajewska
OBJECTIVES: To assess the effectiveness of Lactobacillus reuteri DSM 17938 (L reuteri) for the prevention of diarrhea and antibiotic-associated diarrhea (AAD) in children. METHODS: Hospitalized children who received antibiotics were assigned by a computer-generated list to receive L reuteri at (2x108 colony-forming units) or placebo, twice daily, for the duration of antibiotic treatment. Follow-up was for one week after antibiotic cessation. The primary outcome measures were diarrhea and AAD...
August 24, 2018: Clinical Microbiology and Infection
E Yusuf, R L Hamers
No abstract text is available yet for this article.
August 24, 2018: Clinical Microbiology and Infection
M Drancourt, D Raoult
No abstract text is available yet for this article.
August 24, 2018: Clinical Microbiology and Infection
Marieke M Haalboom, Miriam M H E Blokhuis-Arkes, Roland R J Beuk, Robbert R Meerwaldt, Rob R Klont, Maarten M J Schijffelen, Phil P B Bowler, Michael M Burnet, Eva E Sigl, Job J A M van der Palen
OBJECTIVES: The aim of this study was to determine whether assessment of wound infection differs when culture results from wound biopsy versus wound swab are available in clinical practice. METHODS: For 180 eligible patients, a swab and biopsy were taken from one wound during a regular appointment at a wound care facility in Eastern Netherlands. Culture results from both methods were supplemented with clinical information and provided to a panel of 6 experts who independently assessed each wound as infect or not, separately for swab and biopsy...
August 23, 2018: Clinical Microbiology and Infection
Alvin Yang, Charlie Tan, Nick Daneman, Mark S Hansen, Gilbert Habib, Erwan Salaun, Cécile Lavoute, Sandrine Hubert, Neill Kj Adhikari
OBJECTIVES: Prediction of embolic events (EEs) in infective endocarditis (IE) could inform clinical decisions, such as surgical timing. We conducted a systematic review to more precisely define associations between risk factors and EEs. METHODS: We searched 2 bibliographic databases (1994-2018) for observational studies that reported EEs in IE patients and considered clinical, microbiologic, or echocardiographic risk factors. Studies that did not use Duke criteria or only investigated a subset of IE patients were excluded...
August 23, 2018: Clinical Microbiology and Infection
Amparo Fernández-Rodríguez, Julian L Burton, Laurent Andreoletti, Juan Alberola, Paul Fornes, Irene Merino, Miguel J Martínez, Paola Castillo, Benedita Sampaio-Maia, Inês M Caldas, Veroniek Saegeman, Marta C Cohen
BACKGROUND: Autopsies, including minimally-invasive autopsies, are a powerful tool for determination of the cause of death. When a patient dies from an infection, microbiology is crucial to identify the causative organism. Post-mortem microbiology (PMM) aims to: detect unexpected infections causing sudden deaths; confirm clinically suspected but unproven infection; evaluate the efficacy of antimicrobial therapy; identify emergent pathogens; and recognize medical errors. Additionally, the analysis of the thanatomicrobiome may help to estimate the post-mortem interval...
August 23, 2018: Clinical Microbiology and Infection
Luigia Scudeller, Jesús Rodríguez-Baño, Annelies Zinkernagel, Evelina Tacconelli, Murat Akova, Alexander W Friedrich, Maurizio Sanguinetti, Mical Paul, Mario Poljak
BACKGROUND AND AIM: The European Society of Clinical Microbiology and Infectious Diseases (ESCMID) aims at further developing its role in international medical and scientific guidance in the field of Clinical Microbiology and Infectious Diseases, where many types of guidance documents exist. The ESCMID Executive Committee (EC) and Clinical Microbiology and Infection (CMI) editorial board wish to clarify the terminology and format to be used in ESCMID guidance documents submitted for publication in CMI, and to highlight the principles behind ESCMID guidance documents...
August 23, 2018: Clinical Microbiology and Infection
L Leibovici, M Paul
No abstract text is available yet for this article.
August 15, 2018: Clinical Microbiology and Infection
José Moreira, Ariane Paixão, Juliana Oliveira, Waldir Jaló, Ofélio Manuel, Rafaela Rodrigues, Alexandra Oliveira, Leonardo Tinoco, João Lima, Beatriz Grinsztejn, Valdiléa G Veloso, André M Japiassú, Cristiane C Lamas
OBJECTIVES: To compare the discriminatory capacity of the quick Sequential Organ Failure Assessment (qSOFA) versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting 30-day mortality and intensive care unit (ICU) admission in patients with suspicion of infection at an HIV reference center. METHODS: Prospective cohort study including consecutive adult patients who had suspected infection and subsequently admitted to the medical ward. Variables related to qSOFA and SIRS were measured at admission...
August 14, 2018: Clinical Microbiology and Infection
M Teresa Martin-Gomez, Nicomedes Valenzuela-Lopez, Jose F Cano-Lira
Isolation of Knufia epidermidis from a cutaneous sample of a paediatric patient. This rare species has not been reported previously in Southern Europe.
August 13, 2018: Clinical Microbiology and Infection
K Eljaaly, S Alshehri, S Bhattacharjee, J A Al-Tawfiq, A E Patanwala
OBJECTIVES: Antimicrobial agents are commonly used in ambulatory care settings. Our objective was to examine national-level patterns of contraindications between oral antibacterial or antifungal agents and patients' other oral medications in the US ambulatory care setting. METHODS: This cross-sectional study included multiple year pooled data (2003-2011) from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey (NHAMCS Outpatient Department)...
August 11, 2018: Clinical Microbiology and Infection
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