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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/29934196/evidence-for-dopaminergic-axonal-degeneration-as-an-early-pathological-process-in-parkinson-s-disease
#1
REVIEW
Gerard W O'Keeffe, Aideen M Sullivan
Parkinson's disease is a common neurodegenerative disorder presenting with a variety of motor and non-motor symptoms. The motor symptoms manifest as a result of the progressive degeneration of midbrain dopaminergic neurons. The axons of these neurons project to the striatum as the nigrostriatal pathway, which is a crucial part of the basal ganglia circuitry controlling movement. In addition to the neuronal degeneration, abnormal intraneuronal α-synuclein protein inclusions called Lewy bodies and Lewy neurites increase in number and spread throughout the nervous system as the disease progresses...
June 19, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29934195/parkinsonism-in-a-population-based-study-of-individuals-aged-75-years-the-piet%C3%A3-study
#2
Thiago Cardoso Vale, Maira Tonidandel Barbosa, Elisa de Paula França Resende, Débora Palma Maia, Mauro César Quintão Cunningham, Henrique Cerqueira Guimarães, João Carlos Barbosa Machado, Antônio Lucio Teixeira, Francisco Cardoso, Paulo Caramelli
INTRODUCTION: Parkinsonism is one of the most prevalent neurological syndromes in the elderly. There are only a few epidemiological studies focusing on parkinsonism in oldest-old individuals, particularly in Latin America. This study aims to investigate the prevalence and characteristics of parkinsonism in subjects aged 75 + years living in the community. METHODS: The Pietà study is a population-based investigation on brain aging conducted in Caeté, southeast Brazil...
June 19, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29925486/striatal-dopamine-uptake-and-olfactory-dysfunction-in-patients-with-early-parkinson-s-disease
#3
Yoon-Sang Oh, Joong-Seok Kim, Eo-Jin Hwang, Chul Hyoung Lyoo
INTRODUCTION: Olfactory dysfunction is a sensitive biomarker of neurodegeneration and a cardinal premotor symptom of Parkinson's disease (PD). Although several non-motor symptoms of PD have been correlated with decreased dopamine transporter uptake, olfactory dysfunction and reduced dopamine transporter uptake have not been widely investigated in PD. In this study, we aimed to identify the dopamine transporter status of the corpus striatum and thalamus using a magnetic resonance imaging (MRI)-guided spatial normalization method in patients with PD according to olfactory function...
June 14, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29910156/adverse-events-with-botulinum-toxin-treatment-in-cervical-dystonia-how-much-should-we-blame-placebo
#4
Gonçalo S Duarte, Filipe B Rodrigues, Joaquim J Ferreira, João Costa
INTRODUCTION: Botulinum toxin (BoNT) is the first line therapy for cervical dystonia (CD), with most patients receiving many treatment sessions, and so come to recognize and expect the benefits and harms of BoNT, making it difficult to separate which adverse events (AEs) are driven by BoNT and which come from patients' expectations. METHODS: Using the results of three Cochrane systematic reviews of randomized controlled trials (RCTs) we pooled results to calculate the risk of general and specific AEs associated with BoNT, and the proportion of AEs that cannot be pharmacologically attributed to BoNT...
June 14, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29914840/altered-body-composition-sarcopenia-frailty-and-their-clinico-biological-correlates-in-parkinson-s-disease
#5
Ai Huey Tan, Yin Cheng Hew, Shen-Yang Lim, Norlisah Mohd Ramli, Shahrul Bahyah Kamaruzzaman, Maw Pin Tan, Mathis Grossmann, Ban Hong Ang, Jiun Yan Tan, Mohamad Addin Azhan A Manap, Tun Khong Tay, Siang Lyn Tan, Ru Peng New, Farhana Fadzli, Eng Jui Yee, Foong Ming Moy, Sanjiv Mahadeva, Anthony E Lang
INTRODUCTION: Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. METHODS: 93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers...
June 13, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29929813/botulinum-toxin-in-essential-hand-tremor-a-randomized-double-blind-placebo-controlled-study-with-customized-injection-approach
#6
Shivam Om Mittal, Duarte Machado, Diana Richardson, Divyanshu Dubey, Bahman Jabbari
INTRODUCTION: To evaluate the safety and efficacy of incobotulinumtoxinA (IncoA) injection for treatment of essential hand tremor. In essential tremor and Parkinson's disease tremor, administration of onabotulinumtoxinA via a fixed injection approach improves the tremor but a high percentage of patients (30-70%) develop moderate to severe hand weakness which has limited its use in clinical practice. METHODS: This study was performed from July 2013 to July 2016 on 33 subjects...
June 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29910157/axial-motor-clues-to-identify-atypical-parkinsonism-a-multicentre-european-cohort-study
#7
Carlijn D J M Borm, Florian Krismer, Gregor K Wenning, Klaus Seppi, Werner Poewe, Maria Teresa Pellecchia, Paolo Barone, Erik L Johnsen, Karen Østergaard, Tanya Gurevich, Ruth Djaldetti, Luisa Sambati, Pietro Cortelli, Igor Petrović, Vladimir S Kostić, Hana Brožová, Evžen Růžička, Maria Jose Marti, Eduardo Tolosa, Margherita Canesi, Bart Post, Jorik Nonnekes, Bastiaan R Bloem
OBJECTIVE: Differentiating Parkinson's disease (PD) from atypical parkinsonian disorders (APD) such as Multiple System Atrophy, parkinsonian type (MSA-p) or Progressive Supranuclear Palsy (PSP-RS) can be challenging. Early signs of postural Instability and gait disability (PIGD) are considered clues that may signal presence of APD. However, it remains unknown which PIGD test - or combination of tests - can best distinguish PD from APD. We evaluated the discriminative value of several widely-used PIGD tests, and aimed to develop a short PIGD evaluation that can discriminate parkinsonian disorders...
June 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29907329/consensus-for-the-measurement-of-the-camptocormia-angle-in-the-standing-patient
#8
Nils G Margraf, Robin Wolke, Oliver Granert, Alfredo Berardelli, Bastian R Bloem, Ruth Djaldetti, Alberto J Espay, Alfonso Fasano, Yoshihiko Furusawa, Nir Giladi, Mark Hallett, Joseph Jankovic, Miho Murata, Michele Tinazzi, Jens Volkmann, Daniela Berg, Günther Deuschl
INTRODUCTION: Camptocormia is characterized by a pathological forward flexion of the trunk, which is reversible when lying and worsened by standing and walking. So far there is no consensus on how to measure the angle of flexion, and studies therefore give differing results. Harmonization is needed for both research and clinical practice. Orthopedic measures are not useful for this purpose. METHODS: Two expert raters independently analyzed the photographs of 39 Parkinson patients with camptocormia while standing...
June 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29903582/measuring-disease-progression-and-disability-in-orthostatic-tremor
#9
Nirosen Vijiaratnam, Dharshana Sirisena, Eldho Paul, Kelly L Bertram, David R Williams
OBJECTIVE: To develop a questionnaire quantifying the impact of orthostatic tremor (OT) on patients' function and quality of life to enable longitudinal measurement of disease severity. METHODS: Patients with OT were interviewed in order to identify domains for a new disease-specific impact profile. The OT impact profile (OTIP) included forty-seven items across activities of daily living (9), mobility (9), social participation (2), assistance (8) and emotional effects (19) scored from 0 to 4 (total range 0-188)...
June 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29910155/biallelic-parkin-park2-mutations-can-cause-a-bvftd-phenotype-without-clinically-relevant-parkinsonism
#10
LETTER
Milan Zimmermann, Carlo Wilke, Claudia Schulte, Jessica Hoffmann, Jasmin Klopfer, Matthias Reimold, Kathrin Brockmann, Matthis Synofzik
No abstract text is available yet for this article.
June 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29903584/a-detailed-clinical-study-of-pain-in-1957-participants-with-early-moderate-parkinson-s-disease
#11
Monty A Silverdale, Christopher Kobylecki, Lewis Kass-Iliyya, Pablo Martinez-Martin, Michael Lawton, Sarah Cotterill, K Ray Chaudhuri, Huw Morris, Fahd Baig, Nigel Williams, Leon Hubbard, Michele T Hu, Donald G Grosset
INTRODUCTION: The causes of pain in early/moderate Parkinson's disease (PD) are not well understood. Although peripheral factors such as rigidity, reduced joint movements and poor posture may contribute towards the development of pain, central mechanisms including altered nociceptive processing may also be involved. METHODS: We performed a large clinical study to investigate potential factors contributing towards pain in early/moderate PD. We recruited 1957 PD participants who had detailed assessments of pain, motor and non-motor symptoms...
June 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29903583/-reversible-parkinsonism-following-glyphosate-exposure
#12
LETTER
Daniel A Goldstein, S Eliza Dunn, Katherine Karberg
No abstract text is available yet for this article.
June 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29903581/reply-for-the-comment-on-reversible-parkinsonism-induced-by-acute-exposure-glyphosate
#13
LETTER
Qian Zheng, Jianhong Yin, Lina Zhu, Ling Jiao, Zhu Xu
No abstract text is available yet for this article.
June 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29891432/gastric-emptying-in-parkinson-s-disease-a-mini-review
#14
REVIEW
Karoline Knudsen, Martha Szwebs, Allan K Hansen, Per Borghammer
Patients with Parkinson's disease (PD) experience a range of non-motor symptoms, including constipation and other gastrointestinal problems. These symptoms are sometimes present in the prodromal disease phase. An improved understanding of the underlying pathophysiology is needed considering that PD has been hypothesized to originate in the gut. Delayed gastric emptying time (GET) is often listed as a prevalent gastrointestinal symptom in PD, but the true prevalence is controversial. The aim of this short review was to investigate if GET in PD is dependent on the applied measuring methodology...
June 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29891433/a-need-to-apply-unified-criteria-to-choreoballism-associated-with-glycemic-derangement
#15
LETTER
Chaewon Shin, Tae-Beom Ahn
No abstract text is available yet for this article.
June 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29891429/disease-modifying-anti-rheumatic-drugs-as-a-risk-factor-for-delayed-dbs-implant-infection
#16
LETTER
Marta Oses, Carlos M Ordás, Cici Feliz, Javier Del Val, Joaquin Ayerbe, Pedro J García-Ruiz
No abstract text is available yet for this article.
June 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29887356/movement-disorders-in-non-encephalopathic-hashimoto-s-thyroiditis
#17
LETTER
Marcelo Miranda, M Leonor Bustamante, Mario Campero, Eduardo Wainstein, Paola Toche, Alberto J Espay, Ruth H Walker, Anthony E Lang
No abstract text is available yet for this article.
June 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29885986/clinical-electrophysiological-and-imaging-study-in-essential-tremor-parkinson-s-disease-syndrome
#18
Gennarina Arabia, Angela Lupo, Lucia Ilaria Manfredini, Basilio Vescio, Rita Nisticò, Gaetano Barbagallo, Maria Salsone, Maurizio Morelli, Fabiana Novellino, Giuseppe Nicoletti, Andrea Quattrone, Giuseppe Lucio Cascini, Elan D Louis, Aldo Quattrone
INTRODUCTION: Essential tremor-Parkinson's disease (ET-PD) syndrome is a clinical condition in which individuals with a long-lasting history of Essential tremor (ET) eventually develop Parkinson's disease (PD). The aim of the study was to investigate the accuracy performances of clinical, neurophysiological, and imaging biomarkers in differentiating patients affected by ET-PD syndrome from patients with ET or PD. METHODS: Nineteen patients affected by ET-PD syndrome, 48 ET patients, and 37 tremor-dominant PD (t-PD) patients were included...
June 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29887357/dnajc13-mutation-screening-in-patients-with-parkinson-s-disease-from-south-italy
#19
Monica Gagliardi, Grazia Annesi, Radha Procopio, Maurizio Morelli, Grazia Iannello, Giuseppe Bonapace, Manuela Mancini, Giuseppe Nicoletti, Aldo Quattrone
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder, and the most common neurodegenerative form of parkinsonism. Recently, a pathogenic mutation (p.N855S) in DNAJC13 was linked to autosomal dominant Lewy body PD in a Dutch-German-Russian Mennonite multi-incident kindred, and was found in five additional patients. In this study, we performed a comprehensive screening of the DNAJC13 gene in familial PD and sporadic PD to assess the frequency of known and novel rare nonsynonymous variants...
June 4, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29887355/the-vagus-nerve-becomes-smaller-in-patients-with-parkinson-s-disease-a-preliminary-cross-sectional-study-using-ultrasonography
#20
LETTER
Kazuto Tsukita, Tomoaki Taguchi, Haruhi Sakamaki-Tsukita, Kanta Tanaka, Toshihiko Suenaga
No abstract text is available yet for this article.
June 4, 2018: Parkinsonism & related Disorders
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