Read by QxMD icon Read

Parkinsonism & related Disorders

Roberto López-Blanco, Ignacio J Posada Rodríguez, Julián Benito-León
No abstract text is available yet for this article.
June 15, 2017: Parkinsonism & related Disorders
Byoung June Ahn, Kyum-Yil Kwon
No abstract text is available yet for this article.
June 13, 2017: Parkinsonism & related Disorders
Takuya Konno, Owen A Ross, Hélio A G Teive, Jarosław Sławek, Dennis W Dickson, Zbigniew K Wszolek
Perry syndrome (PS) is a rare hereditary neurodegenerative disease characterized by autosomal dominant parkinsonism, psychiatric symptoms, weight loss, central hypoventilation, and distinct TDP-43 pathology. The mutated causative gene for PS is DCTN1, which encodes the dynactin subunit p150(Glued). Dynactin is a motor protein involved in axonal transport; the p150(Glued) subunit has a critical role in the overall function. Since the discovery of DCTN1 in PS, it has been increasingly recognized that DCTN1 mutations can exhibit more diverse phenotypes than previously thought...
June 12, 2017: Parkinsonism & related Disorders
Roberta Bonomo, Giovanni Mostile, Loredana Raciti, Donatella Contrafatto, Valeria Dibilio, Antonina Luca, Giorgia Sciacca, Calogero Edoardo Cicero, Rosario Vasta, Alessandra Nicoletti, Mario Zappia
OBJECTIVES: To provide a quantitative estimation of motor fluctuations in PD through a 12-h Waking-day Motor Assessment (WDMA) and to develop new WDMA-based tools, the Motor Fluctuation Indices. METHODS: Two independent samples of PD patients (exploratory population N = 51, testing population N = 109) were examined. Patients underwent a WDMA using the Unified Parkinson's Disease Rating Scale (UPDRS) and were classified as either having or not having motor fluctuations...
June 2, 2017: Parkinsonism & related Disorders
Beatriz Echeveste, Eva Covarrubias, Juan Pablo Cabello, María-Rosario Luquin
No abstract text is available yet for this article.
May 31, 2017: Parkinsonism & related Disorders
Anders Bjornestad, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Guido Alves
INTRODUCTION: Clinical staging of Parkinson's disease (PD) is important for patient management and prognosis. The non-motor and functional features visual hallucinations, recurrent falls, dementia and nursing home placement are currently not included in clinical staging schemes, but have been suggested as clinical milestones with important prognostic implications in advanced PD. In this study, we sought to evaluate the potential of these four milestone events for clinical staging and prognosis during the early years of the disease...
May 29, 2017: Parkinsonism & related Disorders
Chin-Man Wang, Wann-Yun Shieh, Yi-Hsin Weng, Yi-Hsuan Hsu, Yih-Ru Wu
INTRODUCTION: Dysphagia is common among patients with Parkinson's disease. Swallowing and its coordination with respiration is extremely important to achieve safety swallowing. Different tools have been used to assess this coordination, however the results have been inconsistent. We aimed to investigate this coordination in patients with Parkinson's disease using a non-invasive method. METHODS: Signals of submental muscle activity, thyroid cartilage excursion, and nasal airflow during swallowing were recorded simultaneously...
May 26, 2017: Parkinsonism & related Disorders
Mariana Moscovich, Gabriela Boschetti, Adriana Moro, Helio A G Teive, Anhar Hassan, Renato P Munhoz
INTRODUCTION: Assessment of variables related to mortality in Parkinson disease (PD) and other parkinsonian syndromes relies, among other sources, on accurate death certificate (DC) documentation. We assessed the documentation of the degenerative disorder on DCs and evaluated comorbidities and causes of death among parkinsonian patients. METHODS: Demographic and clinical data were systematically and prospectively collected on deceased patients followed at a tertiary movement disorder clinic...
May 26, 2017: Parkinsonism & related Disorders
R Song, W Grabowska, M Park, K Osypiuk, G P Vergara-Diaz, P Bonato, J M Hausdorff, M Fox, L R Sudarsky, E Macklin, P M Wayne
PURPOSE: To systematically evaluate and quantify the effects of Tai Chi/Qigong (TCQ) on motor (UPDRS III, balance, falls, Timed-Up-and-Go, and 6-Minute Walk) and non-motor (depression and cognition) function, and quality of life (QOL) in patients with Parkinson's disease (PD). METHODS: A systematic search in 7 electronic databases targeted clinical studies evaluating TCQ for individuals with PD published through August 2016. Meta-analysis was used to estimate effect sizes (Hedges's g) and publication bias for randomized controlled trials (RCTs)...
May 25, 2017: Parkinsonism & related Disorders
Tim Vanbellingen, Thomas Nyffeler, Julia Nigg, Jorina Janssens, Johanna Hoppe, Tobias Nef, René M Müri, Erwin E H van Wegen, Gert Kwakkel, Stephan Bohlhalter
BACKGROUND: Patients with Parkinson's disease exhibit disturbed manual dexterity. This impairment leads to difficulties in activities of daily living, such as buttoning a shirt or hand-writing. The aim of the present study was to investigate the effectiveness of a home-based dexterity program on fine motor skills in a single-blinded, randomized controlled trial, in patients with Parkinson's disease. METHODS: One hundred and three patients with Parkinson's disease (aged between 48 and 80 years, Hoehn & Yahr stage I-IV) were randomized to either a home-based dexterity program (HOMEDEXT) or Thera-band program...
May 25, 2017: Parkinsonism & related Disorders
Mattia Siciliano, Rosa De Micco, Luigi Trojano, Manuela De Stefano, Chiara Baiano, Carla Passaniti, Antonio De Mase, Antonio Russo, Gioacchino Tedeschi, Alessandro Tessitore
INTRODUCTION: The relationship between motor impairment and cognitive deterioration has long been described in Parkinson's disease (PD). The aim of the study was to compare cognitive performance of de novo PD patients in relation to the motor impairment severity according to Hoehn and Yahr (HY) stages. METHODS: Forty de novo PD patients at HY stage I and 40 patients at HY stage II completed a standardized neuropsychological battery. A multivariate analysis of covariance was used to compare cognitive performance between HY groups...
May 25, 2017: Parkinsonism & related Disorders
Jared F Benge, Steve Balsis, Taronish Madeka, Claire Uhlman, Crystal Lantrip, Michael J Soileau
INTRODUCTION: The Montreal Cognitive Assessment (MoCA) is a frequently utilized cognitive screening tool that has attractive clinical attributes when utilized in individuals with Parkinson's disease. However, the construct validity of this instrument has not been well-characterized in Parkinson's samples. The purpose of this study is to explore the underlying factor structure of the MoCA in individuals with early stage Parkinson's disease. METHOD: Item responses from the MoCA in 357 individuals with Parkinson's disease from the Parkinson's Progression Markers Initiative were analyzed first for frequency of errors and polychoric inter item correlations...
May 25, 2017: Parkinsonism & related Disorders
Nicole Schuhmayer, Corinna Weber, Markus Kieler, Bernhard Voller, Walter Pirker, Eduard Auff, Dietrich Haubenberger
INTRODUCTION: In Essential Tremor (ET), tremor characteristics and the impairment caused by tremor may vary from task to task. A variability of tremor frequency between postural and kinetic tasks has been proposed in ET, suggesting either multiple central oscillating networks, or peripheral or proprioceptive feedback-mechanisms. This electrophysiological study aimed to assess tremor frequencies and amplitudes in tasks involving postural and kinetic tremor, and compare findings within and across tasks, to delineate physiological differences underlying individually affected manual tasks in ET...
May 20, 2017: Parkinsonism & related Disorders
Zheng-Dao Deng, Dian-You Li, Chen-Cheng Zhang, Yi-Xin Pan, Jin Zhang, Haiyan Jin, Kristina Zeljec, Shi-Kun Zhan, Bo-Min Sun
BACKGROUND: No effective treatment for tardive dystonia (TD) has been well established. Deep brain stimulation (DBS) can ameliorate motor manifestations in primary dystonia, and may also be an effective approach for TD. OBJECTIVES: This study aimed to illuminate the long-term efficacy and safety of subthalamic nucleus (STN)-DBS in treating TD. METHODS: Ten patients with refractory TD underwent STN-DBS therapy and were assessed by the Burke-Fahn-Marsden dystonia rating scale (BFMDRS), Abnormal Involuntary Movement Scale (AIMS), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and the Short Form (36) Health Survey (SF-36) at four time points: pre-operation, 1 week post-operation, 6 months post-operation, and at a final long-term postsurgical follow-up time point...
May 19, 2017: Parkinsonism & related Disorders
Marjan Jahanshahi
No abstract text is available yet for this article.
May 19, 2017: Parkinsonism & related Disorders
Franziska Maier, Catharine J Lewis, Carsten Eggers, Andrea A Kühn, Henriette Krug, Jens Volkmann, Anna D Kirsch, Lars Wojtecki, Alfons Schnitzler, Günther Deuschl, Joachim K Krauss, Christiane Woopen, Lars Timmermann
No abstract text is available yet for this article.
May 19, 2017: Parkinsonism & related Disorders
T Wirth, S Weibel, S Montaut, K Bigaut, G Rudolf, J Chelly, C Tranchant, M Anheim
No abstract text is available yet for this article.
May 19, 2017: Parkinsonism & related Disorders
Keisuke Suzuki, Hitoshi Suzuki, Yoshinobu Suzuki, Koichi Hirata
We report a patient who developed uncomfortable facial sensations restricted to the cheeks without involvement of the legs. A restless legs syndrome (RLS) variant, "restless face", was considered, as the patient fulfilled four RLS essential features in a modified manner with a marked response to dopamine agonist.
May 18, 2017: Parkinsonism & related Disorders
Yu Wang, Hong Liu, Xiang-Dong Du, Yingyang Zhang, Guangzhong Yin, Ben-Shu Zhang, Jair C Soares, Xiang Yang Zhang
OBJECTIVE: Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays a critical role in the development of depression and the mechanisms of antidepressant. Parkinson disease (PD) is associated with depression and decreased BDNF. The aim of the present study was to examine the association of BDNF with depression in PD, which has not been investigated. METHODS: We recruited 96 PD patients with (n = 46) and without depression (n = 50) and 102 healthy controls and measured the serum BDNF levels in both groups...
May 17, 2017: Parkinsonism & related Disorders
Silvio Peluso, Leonilda Bilo, Marcello Esposito, Antonella Antenora, Anna De Rosa, Sabina Pappatà, Giuseppe De Michele
No abstract text is available yet for this article.
May 17, 2017: Parkinsonism & related Disorders
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"