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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/29449185/association-of-coffee-consumption-and-non-motor-symptoms-in-drug-na%C3%A3-ve-early-stage-parkinson-s-disease
#1
Bang-Hoon Cho, Seong-Min Choi, Joon-Tae Kim, Byeong C Kim
OBJECTIVE: Coffee consumption has an inverse association with the risk of Parkinson's disease (PD). The aim of this study was to investigate the association between coffee consumption and non-motor symptoms (NMSs) in patients with PD. METHODS: In this cross-sectional study, we included 196 early-stage, treatment-naïve PD patients. Coffee consumption history was obtained via semi-structured interviews. NMSs were assessed using the Non-Motor Symptom assessment scale (NMSS)...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449184/relation-of-overactive-bladder-with-motor-symptoms-and-dopamine-transporter-imaging-in-drug-na%C3%A3-ve-parkinson-s-disease
#2
Yasunori Mito, Ichiro Yabe, Hiroaki Yaguchi, Toshiki Takei, Satoshi Terae, Yasutaka Tajima
OBJECTIVES: The aim of the present study was to determine the relation of urinary dysfunction with motor symptoms and nigrostriatal neuron loss in drug-naïve patients with Parkinson's disease (PD). We therefore examined the relation of overactive bladder (OAB) symptoms with motor symptoms and striatal dopamine transporter (DAT) binding measured by [123-Iodine]-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenylnortropane) dopamine transporter single-photon emission computed tomography ( 123 I-FP-CIT SPECT)...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449183/altered-resting-state-voxel-level-whole-brain-functional-connectivity-in-depressed-parkinson-s-disease
#3
Hansheng Wang, Huiyue Chen, Jiahui Wu, Li Tao, Ya Pang, Min Gu, Fajin Lv, Tianyou Luo, Oumei Cheng, Ke Sheng, Jin Luo, Yida Hu, Weidong Fang
BACKGROUND: Depression is one of the most common non-motor symptoms in Parkinson's disease (PD), but its pathogenesis is still not very clear. Recently, degree centrality, a voxel-level whole-brain functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided the most promising way to explore the neural network mechanisms underlying depressed PD. METHODS: Degree centrality, voxel-wise image and clinical symptoms correlation and secondary seed-based FC analyses were performed in twenty-seven drug-naïve, early stage depressed PD patients, 27 non-depressed PD patients and 27 healthy controls (HCs) to reveal voxel-level whole-brain FC changes in depressed PD...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449182/early-onset-generalized-dystonia-starting-in-the-lower-extremities-in-a-patient-with-a-novel-ano3-variant
#4
LETTER
Dallah Yoo, Han-Joon Kim, Jin Sook Lee, Sangmoon Lee, Soo Yeon Kim, Murim Choi, Jong-Hee Chae, Beomseok Jeon
No abstract text is available yet for this article.
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29439855/catechol-o-methyltransferase-comt-genetic-variants-are-associated-with-cognitive-decline-in-patients-with-parkinson-s-disease
#5
Chin-Hsien Lin, Jun-Yu Fan, Han-I Lin, Chia-Wen Chang, Yih-Ru Wu
OBJECTIVE: Catechol-O-methyltransferase (COMT), an enzyme that catalyzes the degradation of dopamine, is necessary for both motor and cognitive functions. Few studies have examined the association between COMT variants and cognition in patients with Parkinson's disease (PD). METHODS: We assessed a cohort of 409 PD patients without dementia who were regularly followed for two years. The Unified Parkinson's Disease Rating Scale (UPDRS) and Mini-Mental State Examination (MMSE) were administered at baseline and during the follow-up...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449187/cortical-atrophy-patterns-in-early-parkinson-s-disease-patients-using-hierarchical-cluster-analysis
#6
Carme Uribe, Barbara Segura, Hugo Cesar Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Anna Campabadal, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Eduard Tolosa, Carme Junque
INTRODUCTION: Cortical brain atrophy detectable with MRI in non-demented advanced Parkinson's disease (PD) is well characterized, but its presence in early disease stages is still under debate. We aimed to investigate cortical atrophy patterns in a large sample of early untreated PD patients using a hypothesis-free data-driven approach. METHODS: Seventy-seven de novo PD patients and 50 controls from the Parkinson's Progression Marker Initiative database with T1-weighted images in a 3-tesla Siemens scanner were included in this study...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449186/the-reorganization-of-functional-architecture-in-the-early-stages-of-parkinson-s-disease
#7
Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R Gizewski, Christian Kremser, Gregor K Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki
INTRODUCTION: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. METHODS: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0.3 years. Resting-state fMRI analysis included region-to-region connectivity in correlation with UPDRS-III scores and computation of Global Efficiency and Degree Centrality...
February 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29429646/a-rare-cause-of-orofacial-dyskinesias
#8
LETTER
Bruno Miranda, Tiago A Mestre, David Rodrigues, Miguel Coelho, Joaquim J Ferreira
No abstract text is available yet for this article.
February 7, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29449188/novel-homozygous-variants-in-atcay-mcoln1-and-sacs-in-complex-neurological-disorders
#9
Humera Manzoor, Norbert Brüggemann, Hafiz Muhammad Jafar Hussain, Tobias Bäumer, Frauke Hinrichs, Muhammad Wajid, Alexander Münchau, Sadaf Naz, Katja Lohmann
BACKGROUND: Neurological disorders comprise a large group of clinically and genetically heterogeneous disorders, many of which have a genetic cause. In addition to a detailed neurological examination, exome sequencing is being increasingly used as a complementary diagnostic tool to identify the underlying genetic cause in patients with unclear, supposedly genetically determined disorders. OBJECTIVE: To identify the genetic cause of a complex movement disorder in five consanguineous Pakistani families...
February 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29429647/4-hydroxybenzoic-acid-for-multiple-system-atrophy
#10
LETTER
Felix Distelmaier
Increasing evidence supports a link between multiple system atrophy and coenzyme Q10 (CoQ10) biosynthesis. However, so far this knowledge was not translated into tangible benefits for affected patients. Poor bioavailability of oral CoQ10 might constitute a major problem. Current research suggests that 4-hydroxybenzoic acid might constitute an interesting alternative treatment option.
February 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29433994/ubiquinone-ubiquinol-4-hydroxybenzoic-acid%C3%A2-what-coenzyme-q10-should-we-care-about-in-multiple-system-atrophy
#11
LETTER
Yaroslau Compta, Esteban Muñoz, Maria J Martí
No abstract text is available yet for this article.
February 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29429645/daytime-sleepiness-in-dementia-with-lewy-bodies-is-associated-with-neuronal-depletion-of-the-nucleus-basalis-of-meynert
#12
Koji Kasanuki, Tanis J Ferman, Melissa E Murray, Michael G Heckman, Otto Pedraza, Fadi S Hanna Al-Shaikh, Takayasu Mishima, Nancy N Diehl, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Neill R Graff-Radford, Dennis W Dickson
INTRODUCTION: Excessive daytime sleepiness is a commonly reported clinical feature of dementia with Lewy bodies (DLB) that can occur early in the disease. Cholinergic depletion is known to be severe in DLB, even when dementia severity is mild. The nucleus basalis of Meynert serves as a primary source of cortical acetylcholine, and has a role in facilitating cortical activation and arousal. We sought to determine whether daytime sleepiness at the initial evaluation of patients with DLB was associated with neuronal loss in the nucleus basalis of Meynert...
February 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29409704/evolution-of-cerebrospinal-fluid-total-%C3%AE-synuclein-in-parkinson-s-disease
#13
Marthe Gurine Førland, Annika Öhrfelt, Ingvild Dalen, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Kenn Freddy Pedersen, Guido Alves, Johannes Lange
INTRODUCTION: Cerebrospinal fluid (CSF) total α-synuclein is considered a potential biomarker for Parkinson's disease (PD), but little is known about the evolution of this marker during the course of the disease. Our objective was to investigate whether CSF total α-synuclein concentrations change over time and are associated with motor and cognitive function in PD. METHODS: CSF total α-synuclein concentrations were quantified in 56 longitudinally followed PD patients, 27 of whom provided CSF repeatedly 2 and/or 4 years later...
January 31, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29398490/reversible-parkinsonism-induced-by-acute-exposure-glyphosate
#14
LETTER
Qian Zheng, Jianhong Yin, Lina Zhu, Ling Jiao, Zhu Xu
No abstract text is available yet for this article.
January 31, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29396090/generalized-dystonia-associated-with-mutation-in-the-histone-methyltransferase-gene-kmt2b-dyt28-and-white-matter-abnormalities
#15
LETTER
José Fidel Baizabal-Carvallo, Marlene Alonso-Juarez
No abstract text is available yet for this article.
January 22, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29371063/cortical-gamma-oscillations-in-isolated-dystonia
#16
Svjetlana Miocinovic, Nicole C Swann, Coralie de Hemptinne, Andrew Miller, Jill L Ostrem, Philip A Starr
We describe a novel electrophysiologic signal from the motor cortex of patients with generalized dystonia - a discrete gamma-band oscillation induced by movement and associated with emergence of dystonia. This was observed using both invasive and non-invasive methods. This phenomenon is similar to the gamma oscillation reported in parkinsonian dyskinesia.
January 19, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29361389/behavioral-addictions-in-early-onset-parkinson-disease-are-associated-with-drd3-variants
#17
Xochitl Helga Castro-Martínez, Pedro J García-Ruiz, Carlos Martínez-García, Juan Carlos Martínez-Castrillo, Lydia Vela, Marina Mata, Irene Martínez-Torres, Cici Feliz-Feliz, Francesc Palau, Janet Hoenicka
BACKGROUND: Impulse control disorders (ICDs) comprise abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian medication. ICDs in PD would develop when dopaminergic treatment overstimulates the dopamine receptor D3 (DR3). Here we studied whether DR3 gene (DRD3) is associated to ICD in PD patients with early-onset (EOPD). METHODS: We performed association analysis of the rs6280 DRD3 single nucleotide variation (SNV) (Ser9Gly) in a clinical sample of 126 non early-onset PD (NEOPD) and 73 EOPD (age at onset < 45)...
January 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29358028/personality-and-parkinson-s-disease-a-meta-analysis
#18
Gabriella Santangelo, Federica Garramone, Chiara Baiano, Alfonsina D'Iorio, Fausta Piscopo, Simona Raimo, Carmine Vitale
INTRODUCTION: Personality changes are considered pre-motor features of Parkinson's disease (PD). Cross-sectional studies revealed that PD patients were more introvert, apprehensive, and cautious than healthy subjects (HS), whereas other studies failed to disclose these behavioural traits. Some studies found mixed results concerning Novelty Seeking (NS) and Harm Avoidance (HA) profiles in PD patients. To better clarify the personality profile in PD we performed a meta-analysis on studies exploring such topic according to both Cloninger's Psychobiological Model (PM) and Big Five Model (BFM) METHODS: The meta-analysis included 17 studies evaluating the personality in PD patients compared with HS...
January 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352721/hyperconnective-and-hypoconnective-cortical-and-subcortical-functional-networks-in-multiple-system-atrophy
#19
Johannes Rosskopf, Martin Gorges, Hans-Peter Müller, Elmar H Pinkhardt, Albert C Ludolph, Jan Kassubek
INTRODUCTION: In multiple system atrophy (MSA), the organization of the functional brain connectivity within cortical and subcortical networks and its clinical correlates remains to be investigated. METHODS: Whole-brain based 'resting-state' fMRI data were obtained from 22 MSA patients (11 MSA-C, 11 MSA-P) and 22 matched healthy controls, together with standardized clinical assessment and video-oculographic recordings (EyeLink®). RESULTS: MSA patients vs...
January 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29352722/daily-intake-of-mucuna-pruriens-in-advanced-parkinson-s-disease-a-16-week-noninferiority-randomized-crossover-pilot-study
#20
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Benedetta Raspini, Michela Barichella, Gianni Pezzoli
BACKGROUND: Thousands of individuals with Parkinson's disease (PD) in low-income countries have limited access to marketed levodopa preparations. Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in tropical areas, may be a sustainable alternative therapy for indigent patients. Single-dose intake of MP proved noninferior to marketed levodopa preparations. METHODS: Fourteen PD patients with motor fluctuations and dyskinesias received MP powder (obtained from roasted seeds) and marketed levodopa/carbidopa (LD/CD) in a randomized order and crossover design over a 16-week period...
January 11, 2018: Parkinsonism & related Disorders
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