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Parkinsonism & related Disorders

Ethan G Brown, Samuel M Goldman, Caroline M Tanner
No abstract text is available yet for this article.
August 7, 2018: Parkinsonism & related Disorders
Cécilia Tremblay, Pascali Durand Martel, Johannes Frasnelli
Patients with Parkinson's Disease (PD) exhibit a considerably diminished sense of smell. The olfactory system is intimately connected to the trigeminal system, responsible for the perception of sensations such as freshness, warmth or piquancy in odorants. Usually, olfactory impairment is associated with a similar reduction of trigeminal sensitivity. A recent study suggests that the trigeminal system is not affected in patients with PD. To test this, we evaluated perception of mixed olfactory/trigeminal stimuli in 23 patients with idiopathic PD and compared them to 22 healthy matched controls...
August 6, 2018: Parkinsonism & related Disorders
Olena Ohlei, Valerija Dobricic, Katja Lohmann, Christine Klein, Christina Lill, Lars Bertram
BACKGROUND AND OBJECTIVES: Dystonia is a genetically complex disease with both monogenic and polygenic causes. For the latter, numerous genetic associations studies have been performed with largely inconsistent results. The aim of this study was to perform a field synopsis including systematic meta-analyses of genetic association studies in isolated dystonia. METHODS: For the field synopsis we systematically screened and scrutinized the published literature using NCBI's PubMed database...
July 27, 2018: Parkinsonism & related Disorders
Juanjuan Du, Tian Wang, Pei Huang, Shishuang Cui, Chao Gao, Yiqi Lin, Rao Fu, Junyi Shen, Yachao He, Yuyan Tan, Shengdi Chen
INTRODUCTION: Multiple system atrophy (MSA) is a progressive neurodegenerative disease. Recent studies revealed decreased coenzyme Q10 (COQ10) levels in the cerebellum and blood samples of MSA patients. But few studies focused on the associations of COQ10 with the clinical symptoms of MSA. In this study, we aimed to quantify plasma COQ10 and characterize its association with clinical features. METHODS: We recruited 40 patients with MSA, 30 patients with Parkinson's disease (PD), and 30 healthy participants...
July 26, 2018: Parkinsonism & related Disorders
Mihoko Okazaki, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Ittetsu Kin, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Cesario V Borlongan, Isao Date
OBJECTIVE: In Parkinson's disease (PD), abnormal postures are often accompanied, which interfere with rehabilitation and subsequent functional recovery. This study investigated the relationship between clinical characteristics and improvement in abnormal postures of PD patients who received subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Seventy-four PD patients were included in this study. Clinical data were analyzed using the patients' functional status at pre- and post-STN-DBS, including anteflexion vs...
July 25, 2018: Parkinsonism & related Disorders
Aldo Quattrone, Maurizio Morelli, Salvatore Nigro, Andrea Quattrone, Basilio Vescio, Gennarina Arabia, Giuseppe Nicoletti, Rita Nisticò, Maria Salsone, Fabiana Novellino, Gaetano Barbagallo, Emilio Le Piane, Pierfrancesco Pugliese, Domenico Bosco, Maria Grazia Vaccaro, Carmelina Chiriaco, Umberto Sabatini, Virginia Vescio, Carlo Stanà, Federico Rocca, Domenico Gullà, Manuela Caracciolo
INTRODUCTION: Differentiating clinically progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) may be challenging, especially in the absence of vertical supranuclear gaze palsy (VSGP). The Magnetic Resonance Parkinsonism Index (MRPI) has been reported to accurately distinguish between PSP and PD, yet few data exist on the usefulness of this biomarker for the differentiation of PSP-P from PD. METHODS: Thirty-four patients with PSP-P, 46 with PSP-Richardson's syndrome (PSP-RS), 53 with PD, and 53 controls were enrolled...
July 25, 2018: Parkinsonism & related Disorders
Kurt A Jellinger
BACKGROUND: With increasing age of the world population, the number of parkinsonian patients with disease onset in very old age is expected to increase. Information about the clinical and morphological phenotype of very old age onset parkinsonism is poor, and only three autopsy-confirmed studies of parkinsonian patients of 80 years and older onset are available. METHODS: A retrospective autopsy study of 345 patients clinically diagnosed as Parkinson disease (PD) included 90 cases with disease onset ≥80 years)...
July 24, 2018: Parkinsonism & related Disorders
Derrick Soh, Andres M Lozano, Alfonso Fasano
No abstract text is available yet for this article.
July 23, 2018: Parkinsonism & related Disorders
Do-Young Kwon, Yuri Kwon, Ji-Won Kim
BACKGROUND: Scans without evidence of dopaminergic deficit (SWEDD) is a radiological nomenclature which refers to patients with a normal dopamine transporter scan presumed to have parkinsonism. The motor features of SWEDD patients should be understood in order to avoid costly and inappropriate treatments. Therefore, it is important to effectively differentiate SWEDD from Parkinson's disease (PD) in the early stage of disease. As bradykinesia is a cardinal clinical feature of parkinsonism, we quantitatively investigated detailed presentations of hand movement using an angular measurement system in SWEDD and PD patients as well as normal controls...
July 23, 2018: Parkinsonism & related Disorders
Camilla Russo, Giuseppe Pontillo, Antonio Pisani, Francesco Saccà, Eleonora Riccio, Antonio Macera, Giovanni Rusconi, Arnaldo Stanzione, Pasquale Borrelli, Vincenzo Brescia Morra, Enrico Tedeschi, Arturo Brunetti, Sirio Cocozza, Giuseppe Palma
INTRODUCTION: Aim of this study is to elucidate possible mechanisms of extrapyramidal damage in Fabry Disease (FD), a condition in which involvement of the motor system has been recently suggested, by simultaneously assessing morphometric and susceptibility changes of striatonigral pathway and their possible correlations with clinical variables. METHODS: In this cross-sectional study, we investigated possible differences in terms of Quantitative Susceptibility Mapping (QSM) values and volumes of different extrapyramidal relays, including striatum and substantia nigra (SN), in 30 FD patients (M/F = 11/19, mean age 42...
July 21, 2018: Parkinsonism & related Disorders
Tiago A Mestre, Shirley Eberly, Caroline Tanner, David Grimes, Anthony E Lang, David Oakes, Connie Marras
INTRODUCTION: PD subtype classification systems attempt to address heterogeneity in PD, a widely recognized feature of the disease with implications in prognosis and therapeutic development. There is no consensus on a valid PD subtype classification system, and its use in clinical research is sparse. Reproducibility has not been systematically assessed as a step for the validation of a PD subtype classification system. We aimed at assessing reproducibility of previously published data-driven PD subtype classification systems in a well-characterized cohort created for clinical research purposes, the Longitudinal and Biomarker Study in Parkinson's Disease (LABS-PD)...
July 20, 2018: Parkinsonism & related Disorders
Aryun Kim, Young Eun Kim, Han-Joon Kim, Ji Young Yun, Hui-Jun Yang, Woong-Woo Lee, Chae Won Shin, Hyeyoung Park, Yu Jin Jung, Ahro Kim, Gwanhee Ehm, Yoon Kim, Mihee Jang, Beomseok Jeon
INTRODUCTION: Previous studies have reported improvement of impulse control disorders (ICDs) after subthalamic nucleus (STN) deep brain stimulation (DBS) as well as some de novo ICDs. However, it is not clear how STN DBS changes ICDs in the long-term. METHODS MATERIALS: Eighty-nine patients with Parkinson's disease (PD) who had received a bilateral STN DBS from 2005 to 2009 and were included in our previous study were followed for 7 years with the modified Minnesota Impulsive Disorders Interview (mMIDI)...
July 20, 2018: Parkinsonism & related Disorders
Jeffrey Ratliff, Roberto A Ortega, Hwai Yin Ooi, Ana Mirallave, Amanda Glickman, Qiping Yu, Deborah Raymond, Susan Bressman, Seth Pullman, Rachel Saunders-Pullman
INTRODUCTION: Objective measures for detection and quantification of dystonic movements may guide both diagnosis and clinical monitoring. Digitized spiral analysis is a non-invasive method used to assess upper limb motor control in movement disorders and may have utility in dystonia. We aimed to determine if digitized spiral analysis can distinguish dystonia subjects from controls, and evaluated correlation with a validated clinical rating scale. METHODS: Kinematic, dynamic, and spatial attributes of Archimedean spirals drawn with an inking pen on a digitizing tablet were compared for participants with brachial dystonia and either Tor1A (DYT1) (n = 15) or THAP1 (DYT6) mutations (n = 12) and age and gender matched controls (n = 27) using Receiver Operator Characteristics (ROC) analysis...
July 20, 2018: Parkinsonism & related Disorders
Benoit Peyronnet, Gregory Vurture, Jose-Alberto Palma, Dominique R Malacarne, Andrew Feigin, Rachael D Sussman, Milton C Biagioni, Ricardo Palmerola, Rebecca Gilbert, Nirit Rosenblum, Steven Frucht, Horacio Kaufmann, Victor W Nitti, Benjamin M Brucker
INTRODUCTION: This study aimed to assess the outcomes of mirabegron for the treatment of overactive bladder (OAB) symptoms in patients with Parkinson disease (PD). METHODS: A retrospective study was conducted including patients with PD who received mirabegron 50 mg once daily for OAB symptoms between 2012 and 2017. The primary endpoint was clinical success defined as any improvement in overactive bladder symptoms self-assessed by the patients 6 weeks after mirabegron initiation...
July 20, 2018: Parkinsonism & related Disorders
Bianca M L Stelten, Bart P C van de Warrenburg, Ron A Wevers, Aad Verrips
Cerebrotendinous xanthomatosis (CTX) is an inborn error of cholesterol and bile acid metabolism, leading to neuropsychiatric and systemic manifestations. Movement disorders have rarely been reported in CTX, while a detailed appreciation of the full phenotypic spectrum is required in order to prevent underdiagnosis of this disease. This review focuses on the frequency of more unusual, non-ataxia and non-spasticity movement disorders reported in CTX. In total, 39 articles were reviewed, describing 55 CTX patients with a movement disorder...
July 19, 2018: Parkinsonism & related Disorders
Mark W Creaby, Michael H Cole
INTRODUCTION: Given the high rate of falls during walking in people with idiopathic Parkinson's disease (PD), identifying at risk individuals and developing targeted interventions to reduce falls incidence is paramount. Numerous studies have investigated gait-related risk factors for falls in PD, however findings are inconsistent across studies, and thus a synthesis of the current evidence is needed to guide clinical practice and the development of interventions to reduce falls risk. The objective of this study was to systematically review the literature regarding the association between walking biomechanics and falls in people with PD, and where possible, perform meta-analyses...
July 17, 2018: Parkinsonism & related Disorders
Jian Wang, Zhen Huang, Yuanfang Li, Fang Ye, Changpeng Wang, Yong Zhang, Xiaoqin Cheng, Guoqiang Fei, Kai Liu, Mengsu Zeng, Chunjiu Zhong, Lirong Jin
INTRODUCTION: We aimed to evaluate whether neuromelanin-sensitive MRI (NM-MRI) features in the substantia nigra pars compacta (SNc) were of diagnostic value to differentiate untreated essential tremor (ET) from de novo tremor-dominant Parkinson's disease (PDT ). METHODS: Eighteen untreated ET patients, 21 de novo PDT patients and 21 healthy control subjects were recruited. All the subjects underwent clinical examination, motor and cognitive evaluations, as well as NM-MRI...
July 17, 2018: Parkinsonism & related Disorders
Srishti Shrestha, Freya Kamel, David M Umbach, Zheng Fan, Laura E Beane Freeman, Stella Koutros, Michael Alavanja, Aaron Blair, Dale P Sandler, Honglei Chen
INTRODUCTION: Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies. METHODS: We screened for DEB among 20,591 male farmers in 2013-2015 using a validated question, and examined its association with pesticide uses and other potential risk factors reported about twenty years ago in 1993-1997. We reported odds ratios (OR) and 95% confidence intervals (CI) from multivariable logistic regression models...
July 10, 2018: Parkinsonism & related Disorders
Reon Kobayashi, Shida Kenji, Asae Taketomi, Hidetomo Murakami, Kenjiro Ono, Hiroshi Otake
Traditional tonic spinal cord stimulation has been shown to improve locomotor behaviour of Parkinson's disease (PD), but may induce paresthesia. Recently developed new stimulation mode, called BurstDR, improved pain, gait and posture of later developed PD patients without inducing paresthesia, in addition to improve emotional symptoms.
July 6, 2018: Parkinsonism & related Disorders
Adam Margolius, Fernando Cubillos, Ying He, Samuel Wu, Peter Schmidt, Tanya Simuni
OBJECTIVE: To determine predictors of clinically meaningful change in Health-Related Quality of Life (HRQL) in patients with Parkinson's disease (PD). BACKGROUND: There is limited literature on longitudinal predictors of change in HRQL in PD. METHODS: Data were collected from the National Parkinson Foundation Quality Improvement Initiative (NPF-QII) registry, a multicenter, longitudinal observational study. HRQL is measured by the Parkinson's Disease Questionnaire-39 (PDQ-39)...
July 2, 2018: Parkinsonism & related Disorders
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