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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/27913125/apomorphine-therapy-in-parkinson-s-and-future-directions
#1
Nataliya Titova, K Ray Chaudhuri
Apomorphine infusion or injection is an important dopamine agonist non-oral therapy usually used in advanced Parkinson's disease (PD) with refractory motor fluctuations. The drug also has appreciable efficacy for nonmotor fluctuations and is the quickest to reverse predictable "off" periods. Current subcutaneous administration, however, is complicated by problems associated with needle-based therapies, such as skin nodule formation, skin irritation, and avoidance of this treatment option by needle-phobic subjects...
November 30, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27919586/practical-management-of-adverse-events-related-to-apomorphine-therapy
#2
Roongroj Bhidayasiri, Pedro J Garcia Ruiz, Tove Henriksen
The potential for adverse events is often cited as a barrier to the use of subcutaneous apomorphine therapy (intermittent injections and continuous infusion) in the management of Parkinson's disease. However, with proactive management most adverse effects are manageable if reported and tackled early enough. As such, proper clinician and patient awareness of the potential adverse effects is important to minimize their impact on the overall clinical utility of this efficacious antiparkinsonian agent. In this paper, we review the key local and systemic adverse effects reported during apomorphine titration, initiation and long-term treatment, and discuss practical management strategies...
November 27, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27919585/the-patient-s-perspective-the-effect-of-levodopa-on-parkinson-symptoms
#3
Heidemarie Zach, Michiel Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
BACKGROUND: Dopaminergic medication adjustments in Parkinson's disease are often solely based on patient reports. However, it is unclear how well patient-based ratings of the levodopa response correlate with clinician-based ratings, and whether this correlation differs between motor symptoms. Here we compare patient-clinician agreement for the effect of levodopa on resting tremor and bradykinesia/rigidity. Furthermore, given patients' reports that tremor is most troublesome during stress, we test for differences in patient-clinician agreement between tremor at rest and stress-induced tremor...
November 27, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27913126/association-between-parkinson-s-disease-and-risk-of-colorectal-cancer
#4
Xin Xie, Xiaoguang Luo, Mingliang Xie
BACKGROUND: Growing evidence has reported that gut microbiota is involved in pathogenesis of Parkinson's disease (PD) and colorectal cancer (CRC), and the association between PD and CRC does not reach a consensus. In order to explore their correlation, herein we summarize the epidemiological evidence and included relevant studies to perform a meta-analysis. METHODS: A comprehensive literature search for relevant articles published was performed in Medline, Web of Science and Embase up to June 30, 2016...
November 22, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27890451/sniffing-the-diagnosis-olfactory-testing-in-neurodegenerative-parkinsonism
#5
F Krismer, B Pinter, C Mueller, P Mahlknecht, M Nocker, E Reiter, A Djamshidian-Tehrani, S M Boesch, G K Wenning, C Scherfler, W Poewe, K Seppi
OBJECTIVE: To determine the diagnostic utility of olfactory testing in patients with neurodegenerative parkinsonism. METHODS: The Sniffin' Sticks test battery for assessment of odor identification, discrimination, and threshold was applied to patients with Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) as well as healthy controls (HC). Two different cohorts were analyzed: A PD/healthy control that included PD patients and HC as well as a PD/diseased control cohort for which patients PD, MSA and PSP were recruited...
November 21, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27889469/changes-in-neural-circuitry-associated-with-depression-at-pre-clinical-pre-motor-and-early-motor-phases-of-parkinson-s-disease
#6
REVIEW
Janina Borgonovo, Camilo Allende-Castro, Almudena Laliena, Néstor Guerrero, Hernán Silva, Miguel L Concha
Although Parkinson's Disease (PD) is mostly considered a motor disorder, it can present at early stages as a non-motor pathology. Among the non-motor clinical manifestations, depression shows a high prevalence and can be one of the first clinical signs to appear, even a decade before the onset of motor symptoms. Here, we review the evidence of early dysfunction in neural circuitry associated with depression in the context of PD, focusing on pre-clinical, pre-motor and early motor phases of the disease. In the pre-clinical phase, structural and functional changes in the substantia nigra, basal ganglia and limbic structures are already observed...
November 21, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27887896/comorbid-parkinson-s-disease-falls-and-fractures-in-the-2010-national-emergency-department-sample
#7
Hind A Beydoun, May A Beydoun, Nishant K Mishra, Ola S Rostant, Alan B Zonderman, Shaker M Eid
INTRODUCTION: Parkinson's disease (PD) is a progressive, neurodegenerative disorder of multifactorial etiology affecting ∼1% of older adults. Research focused on linking PD to falls and bone fractures has been limited in Emergency Department (ED) settings, where most injuries are identified. We assessed whether injured U.S. ED admissions with PD diagnoses were more likely to exhibit comorbid fall- or non-fall related bone fractures and whether a PD diagnosis with a concomitant fall or bone fracture is linked to worse prognosis...
November 19, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27914829/life-threatening-neuroleptic-withdrawal-emergent-syndrome-resembling-status-dystonicus
#8
LETTER
Deborah Pugin, Julien Bally, Judit Horvath, Pierre Pollak, Yvan Gasche, Pierre R Burkhard
No abstract text is available yet for this article.
November 18, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27887895/clavicle-fracture-mimicking-dropped-head-syndrome-in-a-patient-with-multiple-system-atrophy
#9
LETTER
Floriane Le Goff, Fabrice Duparc, Romain Lefaucheur, Damien Fetter, Audrey Rouillé, David Maltête
No abstract text is available yet for this article.
November 18, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27887894/adult-onset-pure-tic-disorder-after-post-traumatic-hypoxic-lesions-of-the-globus-pallidus
#10
LETTER
Chiara Criscuolo, Alessandra D'Amico, Silvio Peluso, Teresa Popolizio, Maria Teresa Pellecchia
No abstract text is available yet for this article.
November 18, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27887893/emotion-modulation-of-the-startle-reflex-in-essential-tremor-blunted-reactivity-to-unpleasant-and-pleasant-pictures
#11
Jacob A Lafo, Ania Mikos, Paul C Mangal, Bonnie M Scott, Erin Trifilio, Michael S Okun, Dawn Bowers
BACKGROUND: Essential tremor is a highly prevalent movement disorder characterized by kinetic tremor and mild cognitive-executive changes. These features are commonly attributed to abnormal cerebellar changes, resulting in disruption of cerebellar-thalamo-cortical networks. Less attention has been paid to alterations in basic emotion processing in essential tremor, despite known cerebellar-limbic interconnectivity. OBJECTIVES: In the current study, we tested the hypothesis that a psychophysiologic index of emotional reactivity, the emotion modulated startle reflex, would be muted in individuals with essential tremor relative to controls...
November 17, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27889470/delayed-administration-of-dopaminergic-drugs-is-not-associated-with-prolonged-length-of-stay-of-hospitalized-patients-with-parkinson-s-disease
#12
Rob Skelly, Lisa Brown, Andrew Fogarty
BACKGROUND: Punctual delivery of dopaminergic medication to Parkinson's disease (PD) patients may be important in optimizing disease control. We tested the hypothesis that prompt delivery of l-dopa medications to emergency hospital inpatients was associated with a decreased length of stay in hospital. METHODS: The study population consisted of all urgent hospitalizations for patients with a diagnosis of PD to the Royal Derby Hospital over a two-year period. Data were extracted on timing of delivery of drugs, number of co-morbidities and length of stay...
November 14, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27863977/foreword
#13
EDITORIAL
A J Lees
No abstract text is available yet for this article.
November 12, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27836715/laughter-is-the-best-medicine-the-second-city-%C3%A2-improvisation-as-an-intervention-for-parkinson-s-disease
#14
Danny Bega, Pamela Palmentera, Abby Wagner, Matt Hovde, Becca Barish, Mary J Kwasny, Tanya Simuni
BACKGROUND: Expressive therapies are increasingly incorporated into the management of Parkinson's disease (PD), although there are little objective data assessing their benefits. OBJECTIVE: Develop and study a novel community Improvisation Theater (IT) program for PD in order to improve quality of life. METHODS: A prospective, rater-blinded, modified cross-over design study of IT for PD. 22 subjects were randomized 1:1 to active-start (AS) or control-start (CS) groups, controlling for age and Hoehn and Yahr stage...
November 5, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27865667/lower-urinary-tract-symptoms-in-parkinson-s-disease-prevalence-aetiology-and-management
#15
REVIEW
Claire McDonald, Kristian Winge, David J Burn
Lower urinary tract symptoms (LUTS) are common in Parkinson's disease (PD), effecting 27-85% of patients with PD. Irritative symptoms predominate and urodynamic studies confirm high prevalence of detrusor overactivity in PD. LUTS are present early in PD and are more common in PD than in age matched controls. The assessment of LUTS in PD is complicated by coexisting bradykinesia and cognitive impairment. Although LUTS become more troublesome as PD progresses it remains unclear if LUTS severity correlates with motor symptoms and/or duration of PD...
November 1, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27852513/premorbid-exercise-engagement-and-motor-reserve-in-parkinson-s-disease
#16
Mun K Sunwoo, Ji E Lee, Jin Y Hong, Byung S Ye, Hye S Lee, Jungsu S Oh, Jae S Kim, Phil H Lee, Young H Sohn
BACKGROUND: Life-long experiences of cognitive activity could enhance cognitive reserve, which may lead individuals to show less cognitive deficits in Alzheimer's disease, despite similar pathological changes. We performed this study to test whether premorbid physical activity may enhance motor reserve in Parkinson's disease (PD) (i.e., less motor deficits despite similar degrees of dopamine depletion). METHODS: We assessed engagement in premorbid leisure-time exercise among 102 drug naive PD patients who had been initially diagnosed at our hospital by dopamine transporter scanning...
November 1, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27836713/early-enteric-neuron-dysfunction-in-mouse-and-human-huntington%C3%A2-disease
#17
LETTER
Serena Sciacca, Mariagrazia Favellato, Michele Madonna, Daniela Metro, Massimo Marano, Ferdinando Squitieri
No abstract text is available yet for this article.
November 1, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27825543/mild-parkinsonian-features-in-dystonia-literature-review-mechanisms-and-clinical-perspectives
#18
REVIEW
Lucy Haggstrom, Paul Darveniza, Stephen Tisch
Dystonia is a hyperkinetic movement disorder that can be highly stigmatizing and disabling. Substantial evidence from animal models, neuropathological, neurophysiological, neuroimaging and clinical studies emphasizes the role of dopaminergic dysfunction in the pathophysiology of dystonia, illustrating possible pathophysiological overlap with parkinsonism. Furthermore, basal ganglia dysfunction has been implicated in the pathogenesis of dystonia, and is well established to underlie the manifestations of Parkinson's disease...
October 29, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27802909/dopamine-d3-receptor-ser9gly-variant-is-associated-with-impulse-control-disorders-in-parkinson-s-disease-patients
#19
LETTER
S Bhattacharjee, J G Talbot, P Vijayashankar
No abstract text is available yet for this article.
October 27, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27836714/abnormal-nociceptive-processing-occurs-centrally-and-not-peripherally-in-pain-free-parkinson-disease-patients-a-study-with-laser-evoked-potentials
#20
Sandro Zambito-Marsala, Roberto Erro, Ruggero Bacchin, Annalisa Fornasier, Federico Fabris, Cecilia Lo Cascio, Franco Ferracci, Francesca Morgante, Michele Tinazzi
BACKGROUND: Several studies documented abnormal nociceptive processing in PD patients. Pain central pathways are accessible by laser-evoked potentials (LEPs). LEPs recording show a N2/P2 complex mostly generated by the anterior cingulate cortex, preceded by an earlier negative component (N1), originating from the opercular cortex. Previous work demonstrated N2/P2 amplitude reduction in PD patients and suggested a centrally-acting pathomechanism for the genesis of pain. However, since a peripheral deafferentation has been recently demonstrated in PD, it is not clear if such LEP abnormalities reflect a mechanism acting centrally or not...
October 24, 2016: Parkinsonism & related Disorders
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