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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/30318448/perampanel-a-new-hope-for-essential-tremor-an-open-label-trial
#1
LETTER
Alexandre Gironell, Berta Pascual-Sedano, Juan Marín-Lahoz
No abstract text is available yet for this article.
October 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30316728/a-novel-exaggerated-spino-bulbo-spinal-like-reflex-of-lower-brainstem-origin
#2
Shabbir Hussain Merchant, Felipe Vial, Giorgio Leodori, Stanley Fahn, Seth L Pullman, Mark Hallett
BACKGROUND: Many different oligosynaptic reflexes are known to originate in the lower brainstem which share phenomenological and neurophysiological similarities. OBJECTIVE: To evaluate and discuss the differences and aberrancies among these reflexes, which are hard to discern clinically using neurophysiological investigations with the help of a case report. METHODS: We describe the clinical and neurophysiological assessment of a young man who had a childhood history of opsoclonus-myoclonus syndrome with residual mild ataxia and myoclonic jerks in the distal extremities presenting with subacute onset total body jerks sensitive to sound and touch (in a limited dermatomal distribution), refractory to medications...
October 6, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30316729/is-hyperhomocysteinemia-associated-with-the-structural-changes-of-the-substantia-nigra-in-parkinson-s-disease-a-two-year-follow-up-study
#3
Guohua Zhang, Chengguo Zhang, Yukai Wang, Lijuan Wang, Yuhu Zhang, Haiqun Xie, Jiancong Lu, Kun Nie
OBJECTIVE: It was recently found that structural changes in the substantia nigra (SN) and motor symptoms become more prominent in Parkinson's disease (PD) patients with striatal silent lacunar infarction (SSLI) than in those without SSLI. Hyperhomocysteinemia (HHCY) was an independent risk factor for SSLI in PD patients. In this follow-up study, we investigated the relationship between HHCY and structural changes of the SN in PD patients. METHODS: A total of 72 untreated early PD patients without SSLI, divided into control and HHCY groups, were enrolled in this study...
October 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297210/naftazone-in-advanced-parkinson-s-disease-an-acute-l-dopa-challenge-randomized-controlled-trial
#4
Jean-Christophe Corvol, Franck Durif, Wassilios G Meissner, Jean-Philippe Azulay, Raphaël Haddad, Raquel Guimarães-Costa, Louise-Laure Mariani, Florence Cormier-Dequaire, Claire Thalamas, Monique Galitzky, Thomas Boraud, Bérengère Debilly, Alexandre Eusebio, Marion Houot, Estelle Dellapina, Véronique Chaigneau, Alexandrine Salis, Lucette Lacomblez, Laurent Benel, Olivier Rascol
INTRODUCTION: There is an unmet need to better control motor complications in Parkinson's disease (PD). Naftazone, which exhibits glutamate release inhibition properties, has shown antiparkinsonian and antidyskinetic activity in preclinical models of PD and in a clinical proof of concept study. METHODS: We conducted a double-blind randomized placebo-controlled cross-over trial in PD patients with motor fluctuations and dyskinesia testing naftazone 160 mg/day versus placebo for 14 days...
October 4, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30314846/progress-in-the-treatment-of-parkinson-plus-syndromes
#5
Nahid Olfati, Ali Shoeibi, Irene Litvan
Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) are the four major proteinopathic neurodegenerative disorders. Currently, there are no disease modifying therapies for these disorders. However, better understanding of the etiopathogenic mechanisms of these disorders has allowed the development of novel therapeutic approaches. These mainly include strategies directed to the pathologic conformational shift, seeding and aggregation, as well as transcellular spread of the proteins that aggregate in the brain which are α-synuclein and tau...
October 3, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297212/phosphorylated-%C3%AE-synuclein-deposits-in-sural-nerve-deriving-from-schwann-cells-a-biomarker-for-parkinson-s-disease
#6
Hui Zhang, Lin Zhu, Li Sun, Yan Zhi, Jian Ding, Yong-Sheng Yuan, Fei-Fei Shen, Xiao Li, Pan Ji, Zhen Wang, Qi Niu, Ke-Zhong Zhang
INTRODUCTION: Paresthesia is common in Parkinson's disease (PD) patients. We assumed that peripheral nerve might be implicated. This study aimed to investigate whether phosphorylated α-synuclein (pSNCA) pathology occurred in sural nerve fibers and to explore the underlying pathogenesis of paresthesia of lower limbs associated with PD. METHODS: Clinical assessments and sural nerve biopsy were performed to evaluate clinical characteristics and the deposition of total α-synuclein (tSNCA) and pSNCA in biopsy pieces using immunochemistry methods on 16 PD patients and 15 controls...
October 2, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297213/dentate-nucleus-stimulation-in-a-patient-with-cerebellar-ataxia-and-tremor-after-cerebellar-stroke-a-long-term-follow-up
#7
LETTER
Rubens Gisbert Cury, Carina França, Egberto Reis Barbosa, Ricardo Galhardoni, Guilherme Lepski, Manoel J Teixeira, Daniel Ciampi de Andrade
No abstract text is available yet for this article.
October 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30292733/single-center-experience-with-medical-cannabis-in-gilles-de-la-tourette-syndrome
#8
Avner Thaler, Shira Arad, Lihi Bar-Lev Schleider, Judith Knaani, Tali Taichman, Nir Giladi, Tanya Gurevich
INTRODUCTION: Patients with Gilles de la Tourette syndrome (GTS) experience reduced function and impaired quality of life. The current medical treatments for this syndrome can cause significant side effects and offer partial symptomatic relief. In a few small trials medical cannabis (MC) has been suggested to offer symptomatic relief with a relatively benign side effect profile. We conducted a real-life assessment of clinical benefit and adverse effects of chronic MC treatment among patients with GTS...
October 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30292732/predictors-of-simulated-driving-performance-in-huntington-s-disease
#9
Milou Jacobs, Ellen P Hart, Yuri Mejia Miranda, Geert Jan Groeneveld, Joop M A van Gerven, Raymund A C Roos
BACKGROUND: As the disease progresses, patients with Huntington's disease (HD), an inherited neurodegenerative disorder, become less independent in their daily life activities and have to consider if they can still drive a car. For most patients, the decision to quit driving is difficult and affects their independence and social activities. OBJECTIVE: To investigate if cognitive, motor, or psychiatric symptoms can predict driving performance in HD gene carriers using a simulator situation...
October 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297209/tsfm-mutations-cause-a-complex-hyperkinetic-movement-disorder-with-strong-relief-by-cannabinoids
#10
LETTER
Andreas Traschütz, Stefanie N Hayer, Benjamin Bender, Ludger Schöls, Saskia Biskup, Matthis Synofzik
No abstract text is available yet for this article.
September 29, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30292735/a-punch-in-the-gut-intestinal-inflammation-links-environmental-factors-to-neurodegeneration-in-parkinson-s-disease
#11
Anouck Becker, Klaus Faßbender, Wolfgang H Oertel, Marcus M Unger
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease...
September 29, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297208/long-term-effects-of-unilateral-deep-brain-stimulation-on-voice-tremor-in-patients-with-essential-tremor
#12
Linda Sandström, Patric Blomstedt, Fredrik Karlsson
INTRODUCTION: Voice tremor (VT) is a common symptom of Essential tremor (ET). Deep brain stimulation (DBS) is an established treatment for ET overall, however, its effect on VT is less clear. The aim of this study was to evaluate long-term effects of DBS on VT and to investigate how VT symptoms develop over time in patients with ET. METHODS: VT scores for the cohort of 81 ET patients that had undergone DBS surgery in the caudal zona incerta (cZi) were analyzed retrospectively...
September 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30279061/alpha-synuclein-staining-in-non-neural-structures-of-the-gastrointestinal-tract-is-non-specific-in-parkinson-disease
#13
LETTER
Chaewon Shin, Sung-Hye Park, Ji Young Yun, Jung Hwan Shin, Han-Kwang Yang, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Joon Kim, Beomseok Jeon
No abstract text is available yet for this article.
September 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30305234/novel-xp21-1-deletion-associated-with-unusual-features-in-a-large-mcleod-syndrome-kindred
#14
LETTER
Olafur Sveinsson, Bjarne Udd, Per Svenningsson, Christoph Gassner, Charlotte Engström, José Miguel Laffita-Mesa, Göran Solders, Stellan Hertegård, Irina Savitcheva, Hans H Jung, Markus Tolnay, Beat M Frey, Martin Paucar
No abstract text is available yet for this article.
September 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30279060/defining-delirium-in-idiopathic-parkinson-s-disease-a-systematic-review
#15
REVIEW
Rachael A Lawson, Claire McDonald, David J Burn
BACKGROUND: Parkinson's disease patients may be at increased risk of delirium and developing adverse outcomes, such as cognitive decline and increased mortality. Delirium is an acute state of confusion that has overlapping symptoms with Parkinson's dementia, making it difficult to identify. This study aimed to determine the diagnostic criteria, prevalence, management strategies and outcomes of delirium in Parkinson's through a systematic review of the literature. METHODS: Seven databases were used to identify all articles published before February 2017 comprising two key terms: "Parkinson's Disease" and "delirium"...
September 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30322685/cannabinoids-in-functional-tic-like-movements
#16
LETTER
Christos Ganos, Kirsten Müller-Vahl
No abstract text is available yet for this article.
September 25, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30297211/predictors-of-self-perceived-stigma-in-parkinson-s-disease
#17
Robert D Salazar, Emma Weizenbaum, Terry D Ellis, Gammon M Earhart, Matthew P Ford, Leland E Dibble, Alice Cronin-Golomb
OBJECTIVE: The burden of PD extends beyond physical limitations and includes significant psychosocial adjustments as individuals undergo changes to their self-perception and how others perceive them. There is limited quantitative evidence of the factors that contribute to self-perceived stigma, which we addressed in the present study. METHODS: In 362 individuals with PD (157 women, 205 men), self-perceived stigma was measured by the four-item stigma subscale of the Parkinson's Disease Questionnaire (PDQ-39)...
September 25, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30314847/evaluation-of-nocturnal-hypokinesia-in-parkinson-s-disease-using-a-novel-patient-proxy-questionnaire-and-correlations-with-objective-monitoring
#18
Roongroj Bhidayasiri, Onanong Phokaewvarangkul, Jirada Sringean, Pablo Martinez-Martin, Chanawat Anan, Nitinan Kantachadvanich, K Ray Chaudhuri, Nobutaka Hattori
BACKGROUND: Nocturnal hypokinesia is a decreased ability to perform sufficient axial rotation and/or trunk flexion to turn in or get out of bed. Currently, there are no validated questionnaires specifically to assess nocturnal hypokinesia in PD patients. OBJECTIVE: To develop and validate a questionnaire to assess PD patients' problems associated with turning or getting out of bed. METHODS: The nocturnal hypokinesia questionnaire (NHQ) consists of 10 items, completed independently by patients and their caregivers...
September 21, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30262378/long-term-outcomes-of-pallidal-deep-brain-stimulation-in-x-linked-dystonia-parkinsonism-xdp-up-to-84-months-follow-up-and-review-of-literature
#19
Joshua Emmanuel E Abejero, Roland Dominic G Jamora, Theodor S Vesagas, Rosalia A Teleg, Raymond L Rosales, Joseph P Anlacan, Monserrat S Velasquez, Jose A Aguilar
INTRODUCTION: X-linked dystonia-parkinsonism (XDP/DYT3/Lubag) patients had improved dystonia and parkinsonism with bilateral pallidal deep brain stimulation (DBS) in the literature. METHOD: We reviewed eleven XDP patients who underwent bilateral pallidal DBS from October 2009 to September 2018. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and Unified Parkinson's Disease Rating Scale (UPDRS)-III scores were reviewed from baseline up to the longest follow-up together with the demographic and clinical data...
September 21, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/30253925/an-atypical-case-of-early-onset-dystonia-with-a-novel-missense-variant-in-kmt2b
#20
LETTER
Xin-Yue Zhou, Jian-Jun Wu, Yi-Min Sun
No abstract text is available yet for this article.
September 19, 2018: Parkinsonism & related Disorders
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