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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/28522172/wall-eyed-bilateral-internuclear-ophtalmoplegia-webino-in-a-patient-with-richardson-s-syndrome-progressive-supranuclear-palsy
#1
LETTER
Leonardo Cruz de Souza, Elisa de Paula França Resende, Daiane Magalhães, Antônio Lúcio Teixeira, Rodrigo Santiago Gomez
No abstract text is available yet for this article.
May 13, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28506531/parkinson-s-disease-and-pregnancy-an-updated-review
#2
REVIEW
Mara Seier, Amie Hiller
Pregnancy does not often occur in the setting of Parkinson's disease (PD) as the most common age of onset is beyond the childbearing years, yet management of these two conditions is crucial for the health of both mother and child. Here we review treatment data of PD during pregnancy, primarily from case reports and drug registries, and focus on available evidence regarding the pregnancy risks for patient and fetus. Historically, it was reported that many women had worsening of symptoms during pregnancy but this may be because anti-parkinsonian medications were not recommended or were under dosed...
May 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28522171/brain-correlates-of-progressive-olfactory-loss-in-parkinson-s-disease
#3
Anna Campabadal, Carme Uribe, Barbara Segura, Hugo C Baggio, Alexandra Abos, Anna Isabel Garcia-Diaz, Maria Jose Marti, Francesc Valldeoriola, Yaroslau Compta, Nuria Bargallo, Carme Junque
BACKGROUND: Olfactory dysfunction is present in a large proportion of patients with Parkinson's disease (PD) upon diagnosis. However, its progression over time has been poorly investigated. The few available longitudinal studies lack control groups or MRI data. OBJECTIVE: To investigate the olfactory changes and their structural correlates in non-demented PD over a four-year follow-up. METHODS: We assessed olfactory function in a sample of 25 PD patients and 24 normal controls of similar age using the University of Pennsylvania Smell Identification test (UPSIT)...
May 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28511835/adcy5-related-movement-disorders-frequency-disease-course-and-phenotypic-variability-in-a-cohort-of-paediatric-patients
#4
Miryam Carecchio, Niccolò E Mencacci, Alessandro Iodice, Roser Pons, Celeste Panteghini, Giovanna Zorzi, Federica Zibordi, Anastasios Bonakis, Argyris Dinopoulos, Joseph Jankovic, Leonidas Stefanis, Kailash P Bhatia, Valentina Monti, Lea R'Bibo, Liana Veneziano, Barbara Garavaglia, Carlo Fusco, Nicholas Wood, Maria Stamelou, Nardo Nardocci
INTRODUCTION: ADCY5 mutations have been recently identified as an important cause of early-onset hyperkinetic movement disorders. The phenotypic spectrum associated with mutations in this gene is expanding. However, the ADCY5 mutational frequency in cohorts of paediatric patients with hyperkinetic movement disorders has not been evaluated. METHODS: We performed a screening of the entire ADCY5 coding sequence in 44 unrelated subjects with genetically undiagnosed childhood-onset hyperkinetic movement disorders, featuring chorea alone or in combination with myoclonus and dystonia...
May 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28487107/magnetic-resonance-parkinsonism-index-and-midbrain-to-pons-ratio-which-index-better-distinguishes-progressive-supranuclear-palsy-patients-with-a-low-degree-of-diagnostic-certainty-from-patients-with-parkinson-disease
#5
Salvatore Nigro, Maurizio Morelli, Gennarina Arabia, Rita Nisticò, Fabiana Novellino, Maria Salsone, Federico Rocca, Aldo Quattrone
INTRODUCTION: Several studies have compared the performances of midbrain to pons area ratio (M/P) and the Magnetic Resonance Parkinsonism Index (MRPI) in distinguishing patients with Progressive Supranuclear Palsy (PSP) from those with Parkinson's disease (PD) with conflicting results. The current study aimed to compare the performance of these indexes in a well-characterized sample of PSP patients using either a manual or a fully automated approach to measure the brainstem structures involved in M/P and MRPI calculation...
May 3, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28483388/enteric-alpha-synuclein-pathology-in-lrrk2-g2019s-parkinson-s-disease
#6
LETTER
Tiphaine Rouaud, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Mathieu Anheim, Pascal Derkinderen
No abstract text is available yet for this article.
May 3, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28457650/orthostatic-myoclonus-after-brain-tumor-radiation-insights-from-two-lesional-cases
#7
Jeremy K Cutsforth-Gregory, Julie E Hammack, Joseph Y Matsumoto
INTRODUCTION: Orthostatic myoclonus (OM) is a recognized syndrome of gait unsteadiness accompanied by lower limb myoclonus provoked by the assumption of an upright posture. OM typically affects the elderly and is often associated with neurodegenerative disease. We sought to review the clinical and electrophysiologic characteristics of OM due to brain tumor treatment, the first reported lesional cases of this rare disorder. METHODS: The database of the Mayo Clinic Rochester Movement Disorders Laboratory was searched for all patients diagnosed with OM from January 2007 to December 2016...
April 26, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28476326/clinical-heterogeneity-in-patients-with-idiopathic-blepharospasm-a-cluster-analysis
#8
G Defazio, A Conte, A F Gigante, G Ferrazzano, R Pellicciari, S Dagostino, G Fabbrini, A Berardelli
BACKGROUND: Idiopathic blepharospasm is a clinically heterogeneous condition. It is not known whether the various manifestations become manifest sequentially during the course of the disease or aggregate in separate clusters identifying subpopulations of patients. METHODS: Eighty-nine patients with idiopathic blepharospasm were assessed using k-means cluster analysis to identify relatively homogeneous groups on the basis of low-intragroup/high-intergroup differences across a set of selected variables...
April 25, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28478995/acting-without-being-in-control-exploring-volition-in-parkinson-s-disease-with-impulsive-compulsive-behaviours
#9
Lucia Ricciardi, Patrick Haggard, Lieke de Boer, Chiara Sorbera, Max-Philipp Stenner, Francesca Morgante, Mark J Edwards
BACKGROUND: Several aspects of volitional control of action may be relevant in the pathophysiology of impulsive-compulsive behaviours (ICB) in Parkinson's disease (PD). We aimed to explore multiple aspects of action control, assessing reward-related behaviour, inhibition (externally and internally triggered) and sense of agency in PD patients, with and without ICB compared to healthy subjects. METHODS: Nineteen PD patients with ICB (PD-ICB), 19 PD without ICB (PD-no-ICB) and 19 healthy controls (HC) underwent a battery of tests including: Intentional Binding task which measures sense of agency; Stop Signal Reaction Time (SSRT) measuring capacity for reactive inhibition; the Marble task, assessing intentional inhibition; Balloon Analog Risk Task for reward sensitivity...
April 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28442304/topography-of-essential-tremor
#10
Wei Chen, Franziska Hopfner, Silke Szymczak, Oliver Granert, Stefanie H Müller, Gregor Kuhlenbäumer, Günther Deuschl
INTRODUCTION: Topography of tremor manifestations is poorly investigated in essential tremor. The present study explores the prevalence and clinical correlates of head and/or voice tremor in essential tremor. METHODS: Out of a prospectively designed registry of 972 patients, 884 patients with definite and probable essential tremor had complete information on tremor localization. Demographic and clinical characteristics were compared among four subgroups: group A (without head or voice tremor, n = 619), B (with head but without voice tremor, n = 155), C (with voice but without head tremor, n = 47), and D (with both head and voice tremor, n = 63)...
April 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28442302/facial-twitches-in-adcy5-associated-disease-myokymia-or-myoclonus-an-electromyography-study
#11
Sinem Tunc, Norbert Brüggemann, Magdalena K Baaske, Corinna Hartmann, Karen Grütz, Ana Westenberger, Christine Klein, Alexander Münchau, Tobias Bäumer
OBJECTIVE: A clinical feature in patients with ADCY5 gene mutations are perioral muscle twitches initially described as facial myokymia. METHODS: Five patients with ADCY5-associated disease with facial twitches and truncal jerks underwent electrophysiological investigations of the orbicularis oris and trapezius muscles to delineate neurophysiological characteristics of these phenomena. RESULTS: Electromyography (EMG) recordings showed a complex electrophysiological pattern with brief bursts of less than 100 ms and longer bursts with a duration of 100-300 ms up to several seconds in keeping with myoclonus and chorea, respectively, as key findings...
April 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28442301/dystonia-due-to-bilateral-caudate-hemorrhage-associated-with-a-col4a1-mutation
#12
LETTER
Taku Hatano, Kensuke Daida, Yasunobu Hoshino, Yuanzhe Li, Hirotomo Saitsu, Naomichi Matsumoto, Nobutaka Hattori
No abstract text is available yet for this article.
April 18, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28442303/clinical-evaluation-of-ropinirole-controlled-release-formulation-at-18-24%C3%A2-mg-day-in-japanese-patients-with-parkinson-s-disease
#13
Nobutaka Hattori, Kazuko Hasegawa, Katsuaki Sato, Erika Mitsuyama, Yotaro Numachi
INTRODUCTION: There has been no clinical data on Japanese patients with Parkinson's disease with which to examine whether motor symptoms improve and to assess the safety profile after the dose of ropinirole was increased in those who had not achieved an optimal response to the ropinirole immediate-release formulation 15 mg/day or the controlled-release (CR) formulation 16 mg/day. METHODS: This was a multicenter, randomized, double-blind study, followed by an open-label, long-term study...
April 13, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28462804/sca2-family-presenting-as-typical-parkinson-s-disease-34-year-follow-up
#14
Young Eun Kim, Beomseok Jeon, Matthew J Farrer, Erika Scott, Ilaria Guella, Sung Sup Park, Jong Min Kim, Hye Young Park, Aryun Kim, Young Don Son, Zang Hee Cho
OBJECTIVE: We describe a Korean family in SCA2 with long-duration levodopa-responsive parkinsonism without cerebellar ataxia. METHODS: Clinical evaluation, genetic testing, and extensive imaging studies were done. RESULTS: All family members showed a typical Parkinson's disease phenotype without cerebellar ataxia for a long disease duration (up to 34 years). Genetic testing showed 40 CAG repeats and 4 CAA interruptions which is the longest repeat number among the families or patients manifesting with a parkinsonian phenotype without ataxia...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28431829/utility-of-the-new-movement-disorder-society-clinical-diagnostic-criteria-for-parkinson-s-disease-applied-retrospectively-in-a-large-cohort-study-of-recent-onset-cases
#15
Naveed Malek, Michael A Lawton, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Huw R Morris, Nigel M Williams, Nicholas Wood, Donald G Grosset
OBJECTIVE: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients. METHODS: Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria. RESULTS: In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28416330/delayed-responses-of-subthalamic-nucleus-to-deep-brain-stimulation-in-patients-with-parkinson-s-disease
#16
LETTER
Lin Shi, Kai Zhang, Fan-Gang Meng, Guan-Yu Zhu, Ying-Chuan Chen, Jun-Jian Zhou, Zhong-Hai Zhou, Jian-Guo Zhang
No abstract text is available yet for this article.
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28416129/increase-in-parkinson-s-disease-related-mortality-among-males-in-northern-italy
#17
Ugo Fedeli, Elena Schievano
BACKGROUND: According to standard mortality statistics based on the underlying cause of death (UCOD), mortality from Parkinson's disease (PD) is increasing in most European countries. However, mortality trends are better investigated taking into account all the diseases reported in the death certificate (multiple causes of death approach, MCOD). METHODS: All deaths of residents in the Veneto Region (Northern Italy) aged≥45 years with any mention of PD were extracted from 2008 to 2015...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28416128/carbamazepine-responsive-generalized-dystonia-in-fahr-s-disease
#18
LETTER
D Naheed, S Mehta, M K Goyal, V Lal
No abstract text is available yet for this article.
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28462805/iaprd-annual-report-2016
#19
LETTER
Irena Rektorova
No abstract text is available yet for this article.
April 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28410805/startle-responses-in-functional-jerky-movement-disorders-are-increased-but-have-a-normal-pattern
#20
Y E M Dreissen, T Boeree, J H T M Koelman, M A J Tijssen
BACKGROUND: Exaggerated startle reactions have been frequently described in patients with functional movement disorders (FMD). Long onset latencies and inconsistent recruitment pattern are thought to be a hallmark in these patients. The auditory startle reflex has not been systematically assessed though. OBJECTIVES: Assessing the frequency and pattern of the early and late component of the auditory startle response in patients with functional jerky movement disorders...
April 6, 2017: Parkinsonism & related Disorders
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