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Parkinsonism & related Disorders

Elias Paolo Casula, Mario Stampanoni Bassi, Maria Concetta Pellicciari, Viviana Ponzo, Domenica Veniero, Antonella Peppe, Livia Brusa, Paolo Stanzione, Carlo Caltagirone, Alessandro Stefani, Giacomo Koch
BACKGROUND: The effects of deep brain stimulation of the subthalamic nucleus (DBS-STN) and L-dopa (LD) on cortical activity in Parkinson's disease (PD) are poorly understood. OBJECTIVES: By combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) we explored the effects of STN-DBS, either alone or in combination with L-Dopa (LD), on TMS-evoked cortical activity in a sample of implanted PD patients. METHODS: PD patients were tested in three clinical conditions: i) LD therapy with STN-DBS turned on (ON/ON condition); ii) without LD therapy with STN-DBS turned on (OFF/ON condition); iii) without LD therapy with STN-DBS turned off (OFF/OFF condition)...
October 17, 2016: Parkinsonism & related Disorders
Jaweed Haqparwar, Antonio Pepe, Klaus Fassbender, Ulrich Dillmann, Samer Ezziddin, Andrea Schaefer, Daniela Leppert, Jörg Spiegel
INTRODUCTION: Alpha-synuclein pathology (ASP) is a characteristic histopathological finding in idiopathic Parkinson's disease (PD). The ASP involves not only the brain but also extracranial structures. In the present study we utilized MIBG scintigraphy to measure the sympathetic innervation of the major salivary glands. We were interested in whether MIBG uptake in the major salivary glands represents a potential biomarker for ASP in PD. METHODS: We investigated 77 PD patients (age 61 ± 10 years, mean ± SD), while 15 non-PD patients (age 58 ± 15 years) with arterial hypertension, who underwent MIBG scintigraphy to exclude pheochromocytoma, served as age-matched controls...
October 15, 2016: Parkinsonism & related Disorders
Julien Bonenfant, Sophie Drapier, Jean François Houvenaghel, Florian Naudet, Claire Haegelen, Paul Sauleau, Marc Vérin
INTRODUCTION: Over a 3-year period, we monitored the efficacy and safety of deep-brain stimulation of the globus pallidus pars interna in patients with advanced Parkinson's disease whose cognitive, psychiatric impairment and/or dopa-resistant axial motor signs made them ineligible for surgery targeting the subthalamic nucleus. METHODS: A total of 25 patients were assessed before surgery, 1 year and 3 years after surgery, on the UPDRS and a neuropsychological battery...
October 11, 2016: Parkinsonism & related Disorders
Anne-Marie A Wills, Jordan J Elm, Rong Ye, Kelvin L Chou, Sotirios A Parashos, Robert A Hauser, Ivan Bodis-Wollner, Vanessa K Hinson, Chadwick W Christine, Jay S Schneider
INTRODUCTION: Clinical cohort studies suggest that mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). The objectives of this paper were to describe cognitive function in a large clinical trial of early treated PD patients at baseline and over time using two brief cognitive screening tests. METHODS: In total 1741 participants were enrolled in the NINDS Exploratory Trials in Parkinson's disease (NET-PD) Long-term Study-1 (LS-1). The Symbol Digit Modalities Test (SDMT) was collected annually...
October 8, 2016: Parkinsonism & related Disorders
Ali H Rajput, Leslie W Ferguson, Christopher A Robinson, Ilaria Guella, Matthew J Farrer, Alexander Rajput
No abstract text is available yet for this article.
October 7, 2016: Parkinsonism & related Disorders
A Ridder, M L T M Müller, V Kotagal, K A Frey, R L Albin, N I Bohnen
OBJECTIVES: Dopaminergic degeneration affects both nigrostriatal projection neurons and retinal amacrine cells in Parkinson disease (PD). Parkinsonian retinopathy is associated with impaired color discrimination and contrast sensitivity. Some prior studies described associations between color discrimination deficits and cognitive deficits in PD, suggesting that contrast discrimination deficits are due, at least in part, to cognitive deficits in PD. We investigated the relationship between cognitive deficits and impaired contrast sensitivity in PD...
October 7, 2016: Parkinsonism & related Disorders
Bettina Balint, Roberto Erro, Florian Brugger, Ashwani Jha, Amit Batla, Christos Ganos, Elena Antelmi, Kailash P Bhatia
No abstract text is available yet for this article.
October 6, 2016: Parkinsonism & related Disorders
Franziska Hopfner, Dietrich Haubenberger, Wendy R Galpern, Katrina Gwinn, Ashlee Van't Veer, Samantha White, Kailash Bhatia, Charles H Adler, David Eidelberg, William Ondo, Glenn T Stebbins, Caroline M Tanner, Rick C Helmich, Fred A Lenz, Roy V Sillitoe, David Vaillancourt, Jerrold L Vitek, Elan D Louis, Holly A Shill, Matthew P Frosch, Tatiana Foroud, Gregor Kuhlenbäumer, Andrew Singleton, Claudia M Testa, Mark Hallett, Rodger Elble, Günther Deuschl
Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by non-standardized research approaches. The National Institute of Neurological Disorders and Stroke (USA) invited experts in ET and related fields to discuss current knowledge, controversies, and gaps in our understanding of ET and to develop recommendations for future research. Discussion focused on phenomenology and phenotypes, therapies and clinical trials, pathophysiology, pathology, and genetics...
October 4, 2016: Parkinsonism & related Disorders
Daniel E Lumsden, Hortensia Gimeno, Jean-Pierre Lin
OBJECTIVE: The most recent international consensus update on dystonia classification proposed a system based on 2 axes, clinical characteristics and aetiology. We aimed to apply this system to Children and Young People (CAYP) selected for movement disorder surgery, and determine if meaningful groupings of cases could be extracted. METHODS: The 2013 Consensus Committee classification system for dystonia was retrospectively applied to 145 CAYP with dystonic movement disorders...
October 3, 2016: Parkinsonism & related Disorders
Xiaojuan Dan, Chaodong Wang, Jinglin Zhang, Zhuqin Gu, Yongtao Zhou, Jinghong Ma, Piu Chan
INTRODUCTION: Prediction of depression in patients with Parkinson's disease (PD) remains challenging. We investigated whether the common susceptible genetic variants for PD are associated with the risk and improves prediction of development of depression in PD (dPD). METHODS: 1134 individuals with a primary diagnosis of PD were recruited. Demographic information, Unified Parkinson's Disease Rating Scale (UPDRS), and 17-item Hamilton Rating Scale for Depression (HAMD) were obtained...
September 29, 2016: Parkinsonism & related Disorders
Julie M Hall, Kaylena A Ehgoetz Martens, Courtney C Walton, Claire O'Callaghan, Peter E Keller, Simon J G Lewis, Ahmed A Moustafa
Parkinson's disease (PD) is a heterogeneous neurological disorder with a variety of motor and non-motor symptoms. The underlying mechanisms of these symptoms are not fully understood. An increased interest in structural connectivity analyses using diffusion tensor imaging (DTI) in PD has led to an expansion of our understanding of the impact of abnormalities in diffusivity on phenotype. This review outlines the contribution of these abnormalities to symptoms of PD including bradykinesia, tremor and non-tremor phenotypes, freezing of gait, cognitive impairment, mood, sleep disturbances, visual hallucinations and olfactory dysfunction...
September 28, 2016: Parkinsonism & related Disorders
Roman Tatura, Theo Kraus, Armin Giese, Thomas Arzberger, Malte Buchholz, Günter Höglinger, Ulrich Müller
INTRODUCTION: In order to better understand the role of epigenetic influences in the etiology of Parkinson's disease (PD), we studied the expression of microRNAs in gyri cinguli of patients and controls. METHODS: Expression profiling of 744 well-characterized microRNAs in gyri cinguli from patients and controls using TaqMan array microRNA cards. Verification of significantly dysregulated microRNAs by SYBR Green qRT-PCR. RESULTS: First screen by TaqMan array identified 43 microRNAs that were upregulated in gyri cinguli from patients...
September 28, 2016: Parkinsonism & related Disorders
Maria Salsone, Rita Nistico', Basilio Vescio, Fabiana Novellino, Maurizio Morelli, Angela Lupo, Gennarina Arabia, Aldo Quattrone
OBJECTIVE: To investigate heart rate variability (HRV) in patients with Essential Tremor (ET) in comparison with patients with Parkinson's Disease (PD). METHODS: This is a cross sectional control study including 10 patients with ET, 10 patients with PD and 10 age-sex-matched controls. In patients and controls, we measured the components of HRV analysis in the frequency domain during a daytime period of 12-h. Selected HRV variables were low-frequency (LF) and high-frequency (HF), conventionally considered to be influenced by the sympathetic system and the parasympathetic system respectively...
September 28, 2016: Parkinsonism & related Disorders
Kelly A Mills, Zoltan Mari, Gregory M Pontone, Alexander Pantelyat, Angela Zhang, Nadine Yoritomo, Emma Powers, Jason Brandt, Ted M Dawson, Liana S Rosenthal
BACKGROUND: In Parkinson's disease, the association between objective and patient-reported measures of cognitive dysfunction is unknown and highly relevant to research and clinical care. OBJECTIVE: To determine which cognitive domain-specific Montreal Cognitive Assessment (MoCA) subscores are most strongly associated with patient-reported cognitive impairment on question 1 (Q1) of the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
September 27, 2016: Parkinsonism & related Disorders
Michael Lawton, Michele T M Hu, Fahd Baig, Claudio Ruffmann, Eilidh Barron, Diane M A Swallow, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, Nigel Williams, David J Burn, Thomas Foltynie, Huw R Morris, Nicholas W Wood, Margaret T May, Donald G Grosset, Yoav Ben-Shlomo
BACKGROUND: Impaired olfaction is an important feature in Parkinson's disease (PD) and other neurological diseases. A variety of smell identification tests exist such as "Sniffin' Sticks" and the University of Pennsylvania Smell Identification Test (UPSIT). An important part of research is being able to replicate findings or combining studies in a meta-analysis. This is difficult if olfaction has been measured using different metrics. We present conversion methods between the: UPSIT, Sniffin' 16, and Brief-SIT (B-SIT); and Sniffin' 12 and Sniffin' 16 odour identification tests...
September 25, 2016: Parkinsonism & related Disorders
Kelly A Mills, Zoltan Mari, Catherine Bakker, Vanessa Johnson, Gregory M Pontone, Alexander Pantelyat, Juan C Troncoso, Olga Pletnikova, Ted M Dawson, Liana S Rosenthal
INTRODUCTION: Gait impairment in Parkinson's Disease (PD) is often severely disabling, yet frequently remains refractory to treatment. The locus coeruleus (LC) has diffuse noradrenergic projections that are thought to play a role in gait function. Enhancement of norepinephrine transmission may improve gait in some PD patients. We hypothesized that the severity of PD pathology, and more specifically, Lewy bodies and neuronal loss in the LC, would correlate with the severity of gait dysfunction in PD...
September 25, 2016: Parkinsonism & related Disorders
Danielle Aldridge, Deborah Theodoros, Anthony Angwin, Adam P Vogel
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms for many individuals with Parkinson's disease (PD). However, STN DBS does not appear to influence speech in the same way, and may result in a variety of negative outcomes for people with PD (PWP). A high degree of inter-individual variability amongst PWP regarding speech outcomes following STN DBS is evident in many studies. Furthermore, speech studies in PWP following STN DBS have employed a wide variety of designs and methodologies, which complicate comparison and interpretation of outcome data amongst studies within this growing body of research...
September 23, 2016: Parkinsonism & related Disorders
Angel Golimstok, María José García Basalo
No abstract text is available yet for this article.
September 22, 2016: Parkinsonism & related Disorders
Ai Huey Tan, Soon Chai Low, Cheng Yin Tan, Kheng Seang Lim, Chong Tin Tan, Shen-Yang Lim
No abstract text is available yet for this article.
September 22, 2016: Parkinsonism & related Disorders
A Nicoletti, A Luca, M Luca, G Donzuso, G Mostile, L Raciti, D Contrafatto, V Dibilio, G Sciacca, C E Cicero, R Vasta, A Petralia, M Zappia
No abstract text is available yet for this article.
September 21, 2016: Parkinsonism & related Disorders
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