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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/28216058/sca13-causes-dominantly-inherited-non-progressive-myoclonus-ataxia
#1
Solveig Montaut, Emmanuelle Apartis, Jean-Baptiste Chanson, Claire Ewenczyk, Mathilde Renaud, Claire Guissart, Jean Muller, André Pierre Legrand, Alexandra Durr, Vincent Laugel, Michel Koenig, Christine Tranchant, Mathieu Anheim
INTRODUCTION: Spinocerebellar ataxia 13 (SCA13) is a rare autosomal dominant cerebellar ataxia. To our knowledge, its association to movement disorders has never been described. We aimed at reporting 8 new SCA13 cases with a focus on movement disorders especially myoclonus. METHODS: We performed a detailed neurological examination and neurophysiological recording in 8 patients consecutively diagnosed with SCA13 between December 2013 and October 2015 and followed up in two French tertiary centers...
February 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28215730/effects-of-intracerebral-neurotrophic-factor-application-on-motor-symptoms-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#2
REVIEW
Shane V Hegarty, David J Lee, Gerard W O'Keeffe, Aideen M Sullivan
INTRODUCTION: Neurotrophic factors (NTFs) have been evaluated for neuroprotective effects in Parkinson's disease (PD). However, clinical trials examining the efficacy of intracerebral administration of NTFs on motor symptoms in PD have produced mixed results, and are thus inconclusive. The objective of this systematic review and meta-analysis was to determine the effects of intracerebral NTF application on motor symptoms in people with PD. METHODS: We searched PubMed, MEDLINE, EMBASE, and Cochrane from inception through to March 31 2016 for open-label trials and randomized controlled trials (RCTs) which intracerebrally administered NTFs to PD patients, and which performed motor examination using the Unified Parkinson's Disease Rating Scale...
February 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28215729/occurrence-of-crohn-s-disease-with-parkinson-s-disease
#3
LETTER
Shinsuke Fujioka, Sadie E Curry, Kathleen D Kennelly, Pawel Tacik, Michael G Heckman, Yoshio Tsuboi, Audrey J Strongosky, Jay A van Gerpen, Ryan J Uitti, Owen A Ross, Tsuneya Ikezu, Zbigniew K Wszolek
We retrospectively investigated the co-occurrence of Crohn's disease in a cohort of 876 patients with Parkinson's disease, based on the observation that LRRK2 is a shared genetic risk factor. We identified 2 patients with Crohn's disease; this number was consistent with the number of cases expected in the general population.
February 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28214262/sca-35-presenting-as-isolated-treatment-resistant-dystonic-hand-tremor
#4
LETTER
Alfonso Fasano, Mojgan Hodaie, Renato P Munhoz, Mohammad Rohani
No abstract text is available yet for this article.
February 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28214265/association-between-dopaminergic-dysfunction-and-anxiety-in-de-novo-parkinson-s-disease
#5
Marina Picillo, Gabriella Santangelo, Roberto Erro, Autilia Cozzolino, Marianna Amboni, Carmine Vitale, Paolo Barone, Maria Teresa Pellecchia
OBJECTIVES: To explore the relationships between nigrostriatal dysfunction and neuropsychiatric symptoms (including anxiety, depression and apathy) in a large cohort of newly diagnosed, drug-naïve Parkinson disease (PD) patients compared to a cohort of healthy controls (HC). METHODS: This is a cross-sectional analysis of the Parkinson's Progression Markers Initiative (PPMI) cohort at baseline, including 405 PD patients and 187 HC. Nigrostriatal degeneration was evaluated by means of SPECT DAT scan...
February 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28214263/a-novel-de-novo-mutation-in-the-atp1a3-gene-causing-rapid-onset-dystonia-parkinsonism
#6
LETTER
Gregor R Wenzel, Katja Lohmann, Andrea A Kühn
No abstract text is available yet for this article.
February 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28215728/domain-specific-accuracy-of-the-montreal-cognitive-assessment-subsections-in-parkinson-s-disease
#7
Taylor R Hendershott, Delphine Zhu, Seoni Llanes, Kathleen L Poston
OBJECTIVE: The Montreal Cognitive Assessment (MoCA) is among the most widely adopted screening tools for cognitive impairment because it includes tests in multiple domains and is available in 55 languages. The MoCA is often the only formal cognitive assessment available when comprehensive neuropsychological testing is not practical, such as rural clinical settings or large retrospective and multi-lingual research settings. However, the MoCA domain-specific subsections have never been formally assessed for sensitivity or specificity...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28202373/is-fatigue-associated-with-cognitive-dysfunction-in-early-parkinson-s-disease
#8
Benzi M Kluger, Kenn Freddy Pedersen, Ole-Bjorn Tysnes, Solgunn O Ongre, Bjørg Øygarden, Karen Herlofson
INTRODUCTION: Fatigue is a common and disabling symptom which may be seen in early Parkinson's disease (PD). Our understanding of the phenomenology and etiology of fatigue in PD is limited. The objective of this study was to determine whether fatigue was related to cognition in early PD patients. METHODS: The study is part of the Norwegian ParkWest project, a population-based cohort study, comprising 184 de novo, drug-naïve patients with PD. PD was diagnosed according to the Gelb criteria...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28202372/gut-microbiota-implications-in-parkinson-s-disease
#9
REVIEW
Arun Parashar, Malairaman Udayabanu
Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. Commensal GM modulates brain development and behavior and has been implicated in several neurological disorders like Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, anxiety, stress and much more. A recent study has shown that Parkinson's disease patients suffer from GM dysbiosis, but whether it is a cause or an effect is yet to be understood. In this review, we try to connect the dots between GM and PD pathology using direct and indirect evidence...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28190675/effectiveness-of-exergaming-in-improving-functional-balance-fatigue-and-quality-of-life-in-parkinson-s-disease-a-pilot-randomized-controlled-trial
#10
REVIEW
Camila Gemin Ribas, Letícia Alves da Silva, Marina Ribas Corrêa, Hélio Ghizone Teive, Silvia Valderramas
: Although motor symptoms in Parkinson's disease (PD) are well established, few studies have described the effects of exergaming on the clinical and functional outcomes of PD. OBJECTIVES: To analyze the effectiveness of exergaming in improving functional balance, fatigue, functional exercise capacity and quality of life in PD. METHODS: The study population consisted of 20 patients (12 males and 8 females) aged 61 ± 9.11 years allocated into two groups: an exergaming group (EGG) (n = 10) and a conventional exercise, or control, group (CG) (n = 10)...
February 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28202374/walking-on-four-limbs-a-systematic-review-of-nordic-walking-in-parkinson-disease
#11
REVIEW
Federica Bombieri, Federico Schena, Barbara Pellegrini, Paolo Barone, Michele Tinazzi, Roberto Erro
Nordic Walking is a relatively high intensity activity that is becoming increasingly popular. It involves marching using poles adapted from cross-country skiing poles in order to activate upper body muscles that would not be used during normal walking. Several studies have been performed using this technique in Parkinson disease patients with contradictory results. Thus, we reviewed here all studies using this technique in Parkinson disease patients and further performed a meta-analysis of RCTs where Nordic Walking was evaluated against standard medical care or other types of physical exercise...
February 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28185758/levodopa-carbidopa-intestinal-gel-can-improve-both-motor-and-non-motor-experiences-of-daily-living-in-parkinson-s-disease-an-open-label-study
#12
Annamária Juhász, Zsuzsanna Aschermann, Péter Ács, József Janszky, Márton Kovács, Attila Makkos, Márk Harmat, Dalma Tényi, Kázmér Karádi, Sámuel Komoly, Annamária Takáts, Adrián Tóth, Helga Nagy, Péter Klivényi, György Dibó, Lívia Dézsi, Dénes Zádori, Ádám Annus, László Vécsei, Lajos Varannai, Norbert Kovács
BACKGROUND: Levodopa/carbidopa intestinal gel therapy (LCIG) can efficiently improve several motor and non-motor symptoms of advanced Parkinson's disease (PD). The recently developed Movement Disorder Society-sponsored Unified Parkinson's Disease Rating Scale (MDS-UPDRS) improved the original UPDRS making it a more robust tool to evaluate therapeutic changes. However, previous studies have not used the MDS-UPDRS and the Unified Dyskinesia Rating Scale (UDysRS) to assess the efficacy of LCIG...
February 3, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28173973/personality-and-addictive-behaviours-in-early-parkinson-s-disease-and-rem-sleep-behaviour-disorder
#13
Fahd Baig, Michael A Lawton, Michal Rolinski, Claudio Ruffmann, Johannes C Klein, Kannan Nithi, David Okai, Yoav Ben-Shlomo, Michele T M Hu
INTRODUCTION: Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction. METHODS: 941 population-ascertained PD subjects within 3...
February 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28214264/identification-of-candidate-cerebrospinal-fluid-biomarkers-in-parkinsonism-using-quantitative-proteomics
#14
N K Magdalinou, A J Noyce, R Pinto, E Lindstrom, J Holmén-Larsson, M Holtta, K Blennow, H R Morris, T Skillbäck, T T Warner, A J Lees, I Pike, M Ward, H Zetterberg, J Gobom
INTRODUCTION: Neurodegenerative parkinsonian syndromes have significant clinical and pathological overlap, making early diagnosis difficult. Cerebrospinal fluid (CSF) biomarkers may aid the differentiation of these disorders, but other than α-synuclein and neurofilament light chain protein, which have limited diagnostic power, specific protein biomarkers remain elusive. OBJECTIVES: To study disease mechanisms and identify possible CSF diagnostic biomarkers through discovery proteomics, which discriminate parkinsonian syndromes from healthy controls...
January 31, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28189463/evaluating-the-performance-of-the-montreal-cognitive-assessment-in-early-stage-parkinson-s-disease
#15
Sandra L Kletzel, Juan Manuel Hernandez, Elizabeth F Miskiel, Trudy Mallinson, Theresa Louise-Bender Pape
INTRODUCTION: Mild cognitive impairment is common in Parkinson's disease, even in the early stages, and can be a risk for developing dementia. To properly track development and progression of cognitive impairment, reliable measurement tools are necessary. The Montreal Cognitive Assessment is currently used as a global cognitive screening tool and has been recommended as an abbreviated diagnostic tool to measure mild cognitive impairment in the context of global cognitive function. However psychometric properties of the Montreal Cognitive Assessment in PD have not been assessed in this context...
January 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28153525/the-terminology-of-akinesia-bradykinesia-and-hypokinesia-past-present-and-future
#16
REVIEW
Johanna C M Schilder, Sandra S Overmars, Johan Marinus, Jacobus J van Hilten, Peter J Koehler
Akinesia, hypokinesia, and bradykinesia are extensively used to describe motor execution disturbances, but are applied inconsistently and cover more conditions than their Greek translations would suggest. We investigated the origins and changes in meaning of these terms over time, particularly in relation to Parkinson's disease (PD). We searched the literature from 1817 to 2015 for use and interpretation of the words akinesia, bradykinesia, hypokinesia, and PD. We found that akinesia and hypokinesia appeared as terms in the 19th century, opposite to hyperkinesia, but were used in the context of PD since 1920, while at the same time the 'bradykinetic syndrome' was introduced...
January 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28109723/octogenarian-parkinsonism-clinicopathological-observations
#17
Ali H Rajput, Emma F Rajput
BACKGROUND: Parkinson's disease is the second most common neurodegenerative disorder for which old age is the best known risk. The proportion of elderly in the world is increasing, resulting in larger pool of people at risk for Parkinson's disease. Several other neurodegenerative disorders also produce Parkinson syndrome. Distinguishing between those variants is only possible with pathological examination of brain. No autopsy confirmed study of 80 years and older onset in parkinsonism cases has been reported...
January 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28108265/palliative-care-and-parkinson-s-disease-meeting-summary-and-recommendations-for-clinical-research
#18
REVIEW
Benzi M Kluger, Siobhán Fox, Suzanne Timmons, Maya Katz, Nicholas B Galifianakis, Indu Subramanian, Julie H Carter, Miriam J Johnson, Edward W Richfield, David Bekelman, Jean S Kutner, Janis Miyasaki
INTRODUCTION: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual wellbeing. Over the past decade there has been an emerging clinical and research interest in the application of palliative care approaches to Parkinson's disease (PD) and outpatient palliative care services are now offered by several movement disorders centers...
January 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28094104/zolpidem-in-movement-disorders-after-cardiac-arrest
#19
LETTER
W O Arruda, M S Silva, D B Bertholdo, R P Munhoz, H A G Teive
No abstract text is available yet for this article.
January 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28094106/expanded-phenotype-and-hippocampal-involvement-in-a-novel-compound-heterozygosity-of-adult-pla2g6-associated-neurodegeneration-park14
#20
LETTER
Joan Philipp Michelis, Elke Hattingen, Florian C Gaertner, Martina Minnerop, Frank Träber, Saskia Biskup, Thomas Klockgether, Sebastian Paus
No abstract text is available yet for this article.
January 10, 2017: Parkinsonism & related Disorders
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