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Parkinsonism & related Disorders

Urban M Fietzek, Mario Paulig, Patrick Fischer, Andres O Ceballos-Baumann, Oliver Neuhaus
No abstract text is available yet for this article.
April 14, 2018: Parkinsonism & related Disorders
Masoom M Abbas, Woon-Puay Koh, Eng-King Tan, Louis C S Tan
No abstract text is available yet for this article.
April 13, 2018: Parkinsonism & related Disorders
Bettina Balint, Elena Antelmi, Niccolò E Mencacci, Amit Batla, Sofia H Eriksson, Matthew C Walker, Adolfo M Bronstein, Kailash P Bhatia
OBJECTIVE: To characterise the distinctive eye movement disorder and the sleep-related dyskinesia in Adenylate cyclase 5 (ADCY5) related disease. METHODS: Formal eye movement examination and video-polysomnography in a cohort of patients with ADCY5 mutations. RESULTS: All three patients had an eye movement disorder characterised by oculomotor apraxia with gaze limitation most prominently in the vertical plane. All patients had disrupted sleep architecture with reduced sleep efficiency due to frequent and prolonged arousals and awakenings in the context of dyskinesia, which could arise from any sleep stage...
April 10, 2018: Parkinsonism & related Disorders
Vanessa Fleury, Pauline Brindel, Nicolas Nicastro, Pierre R Burkhard
OBJECTIVES: A large descriptive cross-sectional population-based prevalence study as well as a retrospective incidence study were undertaken to ascertain the frequency of Parkinson's Disease (PD) and other types of degenerative and non-degenerative parkinsonism in the Canton of Geneva, Switzerland. METHODS: An extensive case-finding approach including records from public hospitals, private neurologists and nursing homes was utilized. All patients with a diagnosis of parkinsonism established between 2003 and 2012 were included...
April 9, 2018: Parkinsonism & related Disorders
M Beudel, R Zutt, A M Meppelink, S Little, J W Elting, B M L Stelten, M Edwards, M A J Tijssen
INTRODUCTION: Differentiating between functional jerks (FJ) and organic myoclonus can be challenging. At present, the only advanced diagnostic biomarker to support FJ is the Bereitschaftspotential (BP). However, its sensitivity is limited and its evaluation subjective. Recently, event related desynchronisation in the broad beta range (13-45 Hz) prior to functional generalised axial (propriospinal) myoclonus was reported as a possible complementary diagnostic marker for FJ. Here we study the value of ERD together with a quantified BP in clinical practice...
April 6, 2018: Parkinsonism & related Disorders
Toshitaka Kawarai, Ryosuke Miyamoto, Eiji Nakagawa, Reiko Koichihara, Takashi Sakamoto, Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Ryosuke Oki, Celeste Montecchiani, Carlo Caltagirone, Antonio Orlacchio, Ayako Hattori, Hideaki Mashimo, Yuishin Izumi, Takahiro Mezaki, Satoko Kumada, Makoto Taniguchi, Fusako Yokochi, Shinji Saitoh, Satoshi Goto, Ryuji Kaji
BACKGROUND: Mutations in Lysine-Specific Histone Methyltransferase 2B gene (KMT2B) have been reported to be associated with complex early-onset dystonia. Almost all reported KMT2B mutations occurred de novo in the paternal germline or in the early development of the patient. We describe clinico-genetic features on four Japanese patients with novel de novo mutations and demonstrate the phenotypic spectrum of KMT2B mutations. METHODS: We performed genetic studies, including trio-based whole exome sequencing (WES), in a cohort of Japanese patients with a seemingly sporadic early-onset generalized combined dystonia...
April 5, 2018: Parkinsonism & related Disorders
José Luiz Pedroso, Thiago Cardoso Vale, Maria Thereza Drumond Gama, Gustavo Ribas, Julio C G Kristochik, Francisco M B Germiniani, Maria Cristina Domingues da Silva Fink, Augusto Cesar Penalva de Oliveira, Helio A G Teive, Orlando G Barsottini
INTRODUCTION: The spectrum of neurologic disorders associated with HIV infection is very broad, resulting from direct virus invasion, opportunistic infections, malignancies and toxic effects of drugs. METHODS: Among a large cohort of ataxia patients (N = 1050) evaluated between 2008 and 2017, we detected four patients with HIV-infection who developed a pure progressive cerebellar ataxia syndrome combined with cerebellar atrophy. RESULTS: Adverse drug effects, opportunistic infections and malignancies as well as immune-reconstitution syndrome were ruled out based on history and laboratory data...
April 5, 2018: Parkinsonism & related Disorders
Vinata Vedam-Mai, Cooper Rodgers, Ashley Gureck, Michael Vincent, Gianna Ippolito, Ahmad Elkouzi, Anthony T Yachnis, Kelly D Foote, Michael S Okun
BACKGROUND: DBS is a well-established therapy for patients with PD and is an emerging therapy for other neuropsychiatric disorders. Despite the rise in DBS usage, relatively little is known about the tissue and cellular responses to DBS. PURPOSE: To examine post-mortem effects of DBS leads by objectively quantifying gliosis around the distal DBS lead tip. METHODS: The UF DBS Brain Bank repository currently has 64 brains, of which 18 cases met criteria for this study...
April 4, 2018: Parkinsonism & related Disorders
Catherine V Kulick, Kathryn M Montgomery, Melissa J Nirenberg
INTRODUCTION: Psychotic symptoms are underdiagnosed in Parkinson's disease (PD), and there is a need for a comprehensive PD psychosis rating scale. METHODS: Cross-sectional analysis of 199 consecutive PD outpatients. After a routine clinical visit that included the Unified Parkinson's Disease Rating Scale (UPDRS) and Non-Motor Symptoms Questionnaire (NMS-Quest), subjects completed the enhanced Scale for the Assessment of Positive Symptoms in PD (eSAPS-PD), a structured clinical interview that included the standard SAPS-PD with additional prompts for delusions and olfactory, gustatory, and minor hallucinations...
April 4, 2018: Parkinsonism & related Disorders
Joaquin A Vizcarra, Hilary E Wilson-Perez, Alfonso Fasano, Alberto J Espay
No abstract text is available yet for this article.
April 4, 2018: Parkinsonism & related Disorders
Kanako Nose, Shinsuke Fujioka, George Umemoto, Kanefumi Yamashita, Hironari Shiwaku, Yuka Hayashi, Takayasu Mishima, Jiro Fukae, Suguru Hasegawa, Yoshio Tsuboi
No abstract text is available yet for this article.
April 3, 2018: Parkinsonism & related Disorders
Marija Dulovic, Eva Schäffer, Frank Leypoldt, Alexander Balck, Susen Schaake, Frauke Hinrichs, Henriette Kirchner, Norbert Brüggemann, Daniela Berg, Katja Lohmann
No abstract text is available yet for this article.
April 3, 2018: Parkinsonism & related Disorders
Christoph Mueller, Anna Hussl, Florian Krismer, Beatrice Heim, Philipp Mahlknecht, Michael Nocker, Christoph Scherfler, Katherina Mair, Regina Esterhammer, Michael Schocke, Gregor K Wenning, Werner Poewe, Klaus Seppi
INTRODUCTION: The hummingbird sign and the morning glory flower sign, reflecting midbrain pathology on MRI, have previously been shown to separate patients with progressive supranuclear palsy (PSP) from those with Parkinson's disease (PD) and multiple system atrophy (MSA). The aim of the present study was to determine the diagnostic accuracy and reproducibility of visual assessment of midbrain atrophy patterns in a large cohort of patients with neurodegenerative parkinsonism. METHODS: Retrospective analysis of midbrain atrophy patterns on T1-weighted MRI in a large cohort of patients with neurodegenerative parkinsonism and healthy controls who underwent MR imaging during their diagnostic work-up...
April 3, 2018: Parkinsonism & related Disorders
Sara Palermo, Adriana Salatino, Alberto Romagnolo, Maurizio Zibetti, Gaetana Chillemi, Leonardo Lopiano
No abstract text is available yet for this article.
April 3, 2018: Parkinsonism & related Disorders
Taisuke Jo, Hideo Yasunaga, Nobuaki Michihata, Yusuke Sasabuchi, Wakae Hasegawa, Hideyuki Takeshima, Yukiyo Sakamoto, Hiroki Matsui, Kiyohide Fushimi, Takahide Nagase, Yasuhiro Yamauchi
INTRODUCTION: Pneumonia is one of the most frequent reasons for hospitalization in patients with Parkinson's disease. The present study aimed to evaluate the impact of Parkinsonism on the clinical courses of elderly patients hospitalized for pneumonia. METHODS: We conducted a retrospective cohort study of patients aged ≥60 years who were hospitalized for pneumonia, using data from a national inpatient database in Japan. We performed one-to-four matching for age and sex between patients with and without Parkinsonism...
April 3, 2018: Parkinsonism & related Disorders
Mélanie L Beaulieu, Martijn L T M Müller, Nicolaas I Bohnen
INTRODUCTION: Peripheral neuropathy is a common condition in the elderly that can affect balance and gait. Postural imbalance and gait difficulties in Parkinson's disease (PD), therefore, may stem not only from the primary neurodegenerative process but also from age-related medical comorbidities. Elucidation of the effects of peripheral neuropathy on these difficulties in PD is important to provide more targeted and effective therapy. The purpose of this study was to investigate the association between lower-limb peripheral neuropathy and falls and gait performance in PD while accounting for disease-specific factors...
April 3, 2018: Parkinsonism & related Disorders
Muhammad Nazmuddin, D L Marinus Oterdoom, J Marc C van Dijk, Jonathan C van Zijl, Anne K Kampman, Gea Drost, Teus van Laar, Martijn Beudel
BACKGROUND: Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) is a new potential treatment for Parkinson's Disease dementia (PDD) and other types of dementia. To get a better understanding of this structure, its local neurophysiological properties and cortical connectivity patterns were studied. METHODS: We simultaneously recorded DBS local field potentials (LFPs) and electroencephalography (EEG) in two patients with PDD. Both patients had DBS electrodes in the internal globus pallidus (GPi) with one or more distal contacts close to or inside the NBM...
March 28, 2018: Parkinsonism & related Disorders
Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean-Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, Iciar Aviles-Olmos, Mario Alvarez-Sanchez, Tomoko Arakaki, Zsuzsanna Aschermann, Eve Benchetrit, Charline Benoit, Alberto Bergareche-Yarza, Amin Cervantes-Arriaga, Anabel Chade, Florence Cormier, Veronika Datieva, David A Gallagher, Nelida Garretto, Zuzana Gdovinova, Oscar Gershanik, Milan Grofik, Vladimir Han, Liis Kadastik-Eerme, Monica M Kurtis, Graziella Mangone, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Michal Minar, Henry P Moore, Mari Muldmaa, Christoph Mueller, Bernadette Pinter, Werner Poewe, Karin Rallmann, Eva Reiter, Carmen Rodriguez-Blazquez, Carlos Singer, Peter Valkovic, Christopher G Goetz, Glenn T Stebbins
BACKGROUND: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. METHODS: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression...
March 28, 2018: Parkinsonism & related Disorders
Marianna Cortese, Trond Riise, Anders Engeland, Alberto Ascherio, Kjetil Bjørnevik
INTRODUCTION: High urate levels have consistently been associated with lower Parkinson's disease (PD) risk among men, but the association is less clear among women. In this study we prospectively investigated the association between high uric acid levels and PD, evaluating potential differences by sex and age. METHODS: This historical cohort study included the entire Norwegian population alive and at least 18 years old on 01/01/2004. We retrieved use of urate-lowering drugs, a marker of high urate levels/gout, from the Norwegian Prescription Database, and followed individuals from 01/01/2005 to PD onset, emigration, death, or end of follow-up on 31/12/2013...
March 28, 2018: Parkinsonism & related Disorders
Giulia Vilela Silva, Patricia Bonilha, Adriana Moro, Renato Munhoz, Salmo Raskin, Tetsuo Ashizawa, Fábio A Nascimento, Hélio A G Teive
No abstract text is available yet for this article.
March 27, 2018: Parkinsonism & related Disorders
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