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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/29233608/reverters-from-pd-mci-to-cognitively-intact-are-at-risk-for-future-cognitive-impairment-analysis-of-the-ppmi-cohort
#1
Jacob D Jones, Taylor P Kuhn, Sarah M Szymkowicz
INTRODUCTION: Past studies have shown that a large portion of individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI) will revert to a cognitively intact (CI) status in the future. Aging studies have shown that individuals who revert from MCI to CI are at increased risk for reconverting to MCI or dementia in the future. The current study examined if individuals who revert from PD-mild cognitive impairment (PD-MCI) to CI will be at increased risk for future PD-MCI and Parkinson's disease dementia (PDD)...
December 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29208345/multi-class-parkinsonian-disorders-classification-with-quantitative-mr-markers-and-graph-based-features-using-support-vector-machines
#2
Rita Morisi, David Neil Manners, Giorgio Gnecco, Nico Lanconelli, Claudia Testa, Stefania Evangelisti, Lia Talozzi, Laura Ludovica Gramegna, Claudio Bianchini, Giovanna Calandra-Buonaura, Luisa Sambati, Giulia Giannini, Pietro Cortelli, Caterina Tonon, Raffaele Lodi
BACKGROUND AND PURPOSE: In this study we attempt to automatically classify individual patients with different parkinsonian disorders, making use of pattern recognition techniques to distinguish among several forms of parkinsonisms (multi-class classification), based on a set of binary classifiers that discriminate each disorder from all others. METHODS: We combine diffusion tensor imaging, proton spectroscopy and morphometric-volumetric data to obtain MR quantitative markers, which are provided to support vector machines with the aim of recognizing the different parkinsonian disorders...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29203059/increased-glutamate%C3%A2-glutamine-levels-in-the-thalamus-of-patients-with-essential-tremor-a-preliminary-proton-mr-spectroscopic-study
#3
Gaetano Barbagallo, Gennarina Arabia, Fabiana Novellino, Rita Nisticò, Maria Salsone, Maurizio Morelli, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The aim of this study was to investigate the thalamic biochemical profile in patients with essential tremor (ET), using proton magnetic resonance spectroscopy (1H-MRS), and to explore the correlations between clinical and biochemical data. METHODS: Sixteen patients with ET and 14 healthy controls participated in this study. After conventional MR imaging, single-voxel 1H-MRS (TR = 2000 ms; TE = 28 ms) was performed by using a PROBE-SV system implemented on a 3-T scanner...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29195729/orthostatic-hypotension-in-parkinson-disease-impact-on-health-care-utilization
#4
Aristide Merola, Russell P Sawyer, Carlo Alberto Artusi, Ritika Suri, Zoe Berndt, Jose' Ricardo Lopez-Castellanos, Jennifer Vaughan, Joaquin A Vizcarra, Alberto Romagnolo, Alberto J Espay
INTRODUCTION: Orthostatic hypotension (OH) represents a frequent yet overlooked source of disability in Parkinson disease (PD). In particular, its impact on health care utilization has been insufficiently examined. We sought to determine the differential health care utilization in PD patients with (PDOH+) and without OH (PDOH-). METHODS: We quantified the emergency room (ER) visits, hospitalizations, outpatient clinic evaluations, phone calls, and e-mails from PD patients on whom supine and orthostatic blood pressure (BP) measurements were obtained during routine clinical practice between June 2013 and July 2016...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29191473/dopamine-receptors-and-bdnf-haplotypes-predict-dyskinesia-in-parkinson-s-disease
#5
Cynthia D J Kusters, Kimberly C Paul, Ilaria Guella, Jeff M Bronstein, Janet S Sinsheimer, Matt J Farrer, Beate R Ritz
OBJECTIVE: Dyskinesia is a known side-effect of the treatment of Parkinson's Disease (PD). We examined the influence of haplotypes in three dopamine receptors (DRD1, DRD2 and DRD3) and the Brain Derived Neurotrophic Factor (BDNF) on dyskinesia. METHODS: Patient data were drawn from a population-based case-control study. We included 418 patients with confirmed diagnoses by movement disorder specialists, using levodopa and a minimum three years disease duration at the time of assessment...
November 24, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29239746/stepping-reaction-time-and-gait-adaptability-are-significantly-impaired-in-people-with-parkinson-s-disease-implications-for-fall-risk
#6
Maria Joana D Caetano, Stephen R Lord, Natalie E Allen, Matthew A Brodie, Jooeun Song, Serene S Paul, Colleen G Canning, Jasmine C Menant
BACKGROUND: Decline in the ability to take effective steps and to adapt gait, particularly under challenging conditions, may be important reasons why people with Parkinson's disease (PD) have an increased risk of falling. This study aimed to determine the extent of stepping and gait adaptability impairments in PD individuals as well as their associations with PD symptoms, cognitive function and previous falls. METHODS: Thirty-three older people with PD and 33 controls were assessed in choice stepping reaction time, Stroop stepping and gait adaptability tests; measurements identified as fall risk factors in older adults...
November 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174196/associations-between-intra-individual-variability-and-montreal-cognitive-assessment-moca-in-cognitive-ageing-and-prodromal-dementia-a-domain-specific-perspective
#7
LETTER
Hanna Lu, Linda C W Lam
No abstract text is available yet for this article.
November 22, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29221675/further-study-of-the-montreal-cognitive-assessment-s-domain-specific-metrics-could-allow-for-international-data-comparison-and-collaboration
#8
LETTER
Taylor R Hendershott, Kathleen L Poston
No abstract text is available yet for this article.
November 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29198499/markers-of-impaired-motor-and-cognitive-volition-in-parkinson-s-disease-correlates-of-dopamine-dysregulation-syndrome-impulse-control-disorder-and-dyskinesias
#9
Jared T Hinkle, Kate Perepezko, Liana S Rosenthal, Kelly A Mills, Alexander Pantelyat, Zoltan Mari, Laura Tochen, Jee Yun Bang, Medha Gudavalli, Nadine Yoritomo, Ankur Butala, Catherine C Bakker, Vanessa Johnson, Emile Moukheiber, Ted M Dawson, Gregory M Pontone
INTRODUCTION: Dopaminergic therapy in Parkinson's disease (PD) can be associated with both motoric (e.g., dyskinesias) and neuropsychiatric adverse effects. Examples of the latter include Dopamine Dysregulation Syndrome (DDS) and impulse control disorder (ICD), which are separate but related behavioral/psychiatric complications of treatment in PD. Dysregulation of volition characterizes both dyskinesias and DDS/ICD; thus, we analyzed potential disease-related correlates in a large PD cohort...
November 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174169/severe-camptocormia-due-to-myositis-of-paraspinal-muscles-as-an-early-manifestation-of-parkinson-s-disease
#10
LETTER
Konrad Whittaker, Nils Schroeter, Michel Rijntjes, Konstanze Guggenberger, Johann Lambeck, Brita Fritsch, Cornelius Weiller, Philipp T Meyer, Soroush Doostkam, Stephan Klebe
No abstract text is available yet for this article.
November 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29169787/comprehensive-blinded-assessment-of-balance-in-orthostatic-tremor
#11
Danish Bhatti, Rebecca Thompson, Yiwen Xia, Amy Hellman, Lorene Schmaderer, Katie Suing, Jennifer McKune, Cynthia Penke, Regan Iske, Bobbi Jo Roeder, Ka-Chun Siu, John M Bertoni, Diego Torres-Russotto
INTRODUCTION: Orthostatic Tremor (OT) is a movement disorder characterized by a sensation of unsteadiness and tremors in the 13-18 Hz range present upon standing. The pathophysiology of OT is not well understood but there is a relationship between the sensation of instability and leg tremors. Despite the sensation of unsteadiness, OT patients do not fall often and balance in OT has not been formally assessed. We present a prospective blinded study comparing balance assessment in patients with OT versus healthy controls...
November 16, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174172/juvenile-onset-parkinsonism-with-pyramidal-signs-due-to-compound-heterozygous-mutations-in-the-f-box-only-protein-7-gene
#12
Lei Wei, Li Ding, Haiyan Li, Yinyao Lin, Yongqiang Dai, Xiaofeng Xu, Qing Dong, Yanjun Lin, Ling Long
BACKGROUND: Juvenile-onset parkinsonism is often caused by genetic factors. Mutations in several autosomal genes, including the F-box only protein 7 (FBXO7) gene, have been found in patients suffering from juvenile-onset parkinsonism with pyramidal signs. Only five types of FBXO7 mutations have been described. Here, we present a case report about a Chinese patient presenting with juvenile-onset parkinsonism likely caused by FBXO7 mutations. METHODS: The patient was a 32-year-old Chinese male...
November 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29233469/olfactory-dysfunctions-in-drug-na%C3%A3-ve-parkinson-s-disease-with-mild-cognitive-impairment
#13
Jin-Woo Park, Do-Young Kwon, Ji Ho Choi, Moon-Ho Park, Ho-Kyoung Yoon
BACKGROUND: Evaluation of olfactory function is valuable for the detection of pre-motor state of Parkinson's disease (PD). PD patients have an increased risk of associated dementia and one-third of PD patients have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients are unclear. This study examined the relationship between olfactory dysfunction and cognitive function in drug-naïve PD at the time of diagnosis with the patterns of olfactory function in PD-MCI patients using the Korean version of the Sniffin' stick test II (KVSS II)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29157745/differential-diagnosis-of-parkinsonian-syndromes-using-dopamine-transporter-and-perfusion-spect
#14
Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahashi
OBJECTIVE: We aimed to assess whether a combined analysis of dopamine transporter (DAT)- and perfusion-SPECT images (or either) could: (1) distinguish atypical parkinsonian syndromes (APS) from Lewy body diseases (LBD; majority Parkinson disease [PD]), and (2) differentiate among APS subgroups (progressive supranuclear palsy [PSP], corticobasal syndrome [CBS], and multiple system atrophy [MSA]). METHODS: We recruited consecutive patients with neurodegenerative parkinsonian syndromes (LBD, n = 46; APS, n = 33)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174171/helicobacter-pylori-infection-is-associated-with-an-increased-risk-of-parkinson-s-disease-a-population-based-retrospective-cohort-study
#15
Huei-Kai Huang, Jen-Hung Wang, Wei-Yi Lei, Chien-Lin Chen, Chih-Ya Chang, Li-Syue Liou
BACKGROUND: Several studies have evaluated the association of Parkinson's disease with Helicobacter pylori (HP) infection, although no cohort studies have evaluated this association among the general population. OBJECTIVE: This study aimed to investigate the risk of Parkinson's disease after HP infection in the general Taiwanese population. METHODS: This study of Taiwanese health insurance data (2000-2012) evaluated 9105 cases of HP infection and 9105 controls matched with propensity scoring...
November 13, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29153535/prevalence-of-psychiatric-disorders-in-patients-with-inherited-or-idiopathic-dystonia
#16
LETTER
Benedetta Demartini, Carla Scattolini, Armando D'Agostino, Antonio E Elia, Luigi M Romito, Orsola Gambini
No abstract text is available yet for this article.
November 13, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174183/speech-induced-cervical-dystonia-an-unusual-task-specific-dystonia
#17
LETTER
Shweta Prasad, Abhishek Lenka, Pramod Kumar Pal
No abstract text is available yet for this article.
November 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29150220/celebrating-thirty-years-of-deep-brain-stimulation-in-movement-disorders-patients-a-successful-marriage-between-neurologists-and-neurosurgeons
#18
LETTER
Rubens Gisbert Cury, Valerie Fraix, Elena Moro
No abstract text is available yet for this article.
November 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29174170/kinsbourne-syndrome-associated-with-cryptococcosis-infection
#19
LETTER
José Renan Miranda Cavalcante-Filho, Francisco Willamy Pedrosa Alves-Filho, Guilherme Bruno Araújo, Pedro Braga-Neto, Espártaco Moraes Lima Ribeiro
No abstract text is available yet for this article.
November 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29137852/dysarthria-in-pallidal-deep-brain-stimulation-in-dystonia-depends-on-the-posterior-location-of-active-electrode-contacts-a-pilot-study
#20
K A M Pauls, P J Bröckelmann, S Hammesfahr, J Becker, A Hellerbach, V Visser-Vandewalle, T A Dembek, I G Meister, L Timmermann
BACKGROUND: Pallidal Deep Brain Stimulation (GPi-DBS) is an efficient treatment for primary dystonia. We investigated stimulation-induced dysarthria, which is the most frequent side-effect of GPi-DBS. METHODS: Speech was recorded while reading a standard text, and performing rapid syllable repetitions ON and OFF DBS in ten dystonia patients (6 men; 3 cervical, 4 segmental, 3 generalized, unselected for DBS-related speech impairments). Speech and articulation rate, pauses, and syllable repetition rates were extracted via acoustic analysis...
November 7, 2017: Parkinsonism & related Disorders
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