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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/28807495/the-colorful-spectrum-of-tourette-syndrome-and-its-medical-surgical-and-behavioral-therapies
#1
Jan Roth
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations). They are preceded by an inner urge. Tics can be temporarily suppressed, but this leads to a powerful re-emergence. The performance of tics results in immediate but transient relief...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28807494/relationship-between-gwas-linked-three-new-loci-in-essential-tremor-and-risk-of-parkinson-s-disease-in-chinese-population
#2
LETTER
Yuan Zhang, Yuwen Zhao, Xiaoting Zhou, Minhan Yi, Kai Li, Xun Zhou, Jifeng Guo, Qian Xu, Xinxiang Yan, Beisha Tang, Qiying Sun
No abstract text is available yet for this article.
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28818560/rotigotine-for-nocturnal-hypokinesia-in-parkinson-s-disease-quantitative-analysis-of-efficacy-from-a-randomized-placebo-controlled-trial-using-an-axial-inertial-sensor
#3
Roongroj Bhidayasiri, Jirada Sringean, Suchapit Chaiwong, Chanawat Anan, Nuntiwat Penkeaw, Amarinee Leaknok, Kamolwan Boonpang, Karn Saksornchai, Watchara Rattanachaisit, Chusak Thanawattano, Priya Jagota
BACKGROUND: Nocturnal hypokinesia is a common symptom in Parkinson's disease (PD), negatively affecting quality of life of both patients and caregivers. However, evidence-based treatment strategies are limited. OBJECTIVE: To evaluate the efficacy of rotigotine transdermal patch, using a wearable sensor, in the management of nocturnal immobility. METHODS: 34 PD subjects with nocturnal immobility were randomized to receive rotigotine transdermal patch (mean ± SD of 10...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28807493/homocysteine-and-cognitive-function-in-parkinson-s-disease
#4
Nicole Licking, Charles Murchison, Brenna Cholerton, Cyrus P Zabetian, Shu-Ching Hu, Thomas J Montine, Amie L Peterson-Hiller, Kathryn A Chung, Karen Edwards, James B Leverenz, Joseph F Quinn
INTRODUCTION: Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson's disease (PD). METHODS: The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28797564/impact-of-anxiety-apathy-and-reduced-functional-autonomy-on-perceived-quality-of-life-in-parkinson-s-disease
#5
Alfonsina D'Iorio, Carmine Vitale, Fausta Piscopo, Chiara Baiano, Anna Paola Falanga, Katia Longo, Marianna Amboni, Paolo Barone, Gabriella Santangelo
INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment...
August 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28784298/evolving-concepts-in-the-pathogenesis-of-dystonia
#6
H A Jinnah, Ellen J Hess
INTRODUCTION: The dystonias are a group of disorders defined by over-contraction of muscles leading to abnormal movements and postures. In recent years, enormous advances have been made in elucidating the neurobiological mechanisms responsible for many types of dystonia. METHODS: A literature review was conducted focusing on evolving concepts in dystonia genetics, anatomy and physiology. RESULTS: The list of genes related to dystonia has grown from a relatively small number to more than 100...
August 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28781201/seven-tesla-mri-of-the-substantia-nigra-in-patients-with-rapid-eye-movement-sleep-behavior-disorder
#7
Daniela Frosini, Mirco Cosottini, Graziella Donatelli, Mauro Costagli, Laura Biagi, Claudio Pacchetti, Michele Terzaghi, Pietro Cortelli, Dario Arnaldi, Enrica Bonanni, Michela Tosetti, Ubaldo Bonuccelli, Roberto Ceravolo
INTRODUCTION: Susceptibility-weighted imaging of the substantia nigra (SN) both at 7 and 3 Tesla (T) has shown high accuracy in distinguishing patients with Parkinson's disease (PD) and healthy subjects (HS). Patients with rapid eye movement (REM) behavior disorder (RBD) can develop synucleinopathies, and such risk is higher with dopamine transporter single photon emission tomography (123I-FP-CIT SPECT) evidence of nigro-striatal dysfunction. We aimed at evaluating SN 7T magnetic resonance imaging (7T-MRI) in patients with RBD and determining the agreement between MRI and 123I-FP-CIT SPECT...
August 2, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28818561/the-rise-and-fall-of-impulse-control-behavior-disorders
#8
Giovanni Cossu, Roberta Rinaldi, Carlo Colosimo
INTRODUCTION: Impulse control disorders (ICDs) are psychiatric disorders characterized by the failure to resist an impulse or by the temptation to perform an act that is harmful to oneself or to others. METHODS: ICDs, including pathological gambling, hypersexuality, compulsive eating and shopping, can occur as a complication of Parkinson's disease (PD) together with other behavioral disorders, including dopamine dysregulation syndrome. This review is based on a literature search updated to May 2017, focusing on the epidemiology, clinical features, and therapeutic options of ICDs associated with PD...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28802760/involvement-of-obliquus-capitis-inferior-muscle-in-dystonic-head-tremor
#9
A Schramm, D Huber, C Möbius, A Münchau, Z Kohl, T Bäumer
INTRODUCTION: Head tremor is a common feature in cervical dystonia (CD) and often less responsive to botulinum neurotoxin (BoNT) treatment than dystonic posturing. Ultrasound allows accurate targeting of deeper neck muscles. METHODS: In 35 CD patients with dystonic head tremor the depth and thickness of the splenius capitis (SPL), semispinalis capitis and obliquus capitis inferior muscles (OCI) were assessed using ultrasound. Ultrasound guided EMG recordings were performed from the SPL and OCI...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28797565/low-adherence-to-antidepressants-is-associated-with-increased-mortality-in-parkinson-disease-patients
#10
Gal Shoval, Brendon Stubbs, Ran D Balicer, Becca Feldman, Moshe Hoshen, Gil Zalsman, Roi Sagy, Eldar Hochman, Abraham Weizman, Amir Krivoy
INTRODUCTION: The purpose of this study was to evaluate the relationship between adherence to antidepressants (AD) and all-cause mortality in a population-based cohort of patients with Parkinson's Disease (PD). METHODS: From a database of more than 4 million people, 8553 patients with PD who purchased an AD at least once between the years 2008-2011 were retrospectively followed for all-cause mortality over 4-years. Adherence was measured as a ratio between dispensed and prescribed durations and was modeled as: non-adherence (<20%, n = 1566), poor (20%-50%, n = 1184), moderate (50%-80%, n = 1584), and good (>80%, n = 4219) adherence...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28789904/untangling-the-tauopathies-current-concepts-of-tau-pathology-and-neurodegeneration
#11
Helen Ling
Tau is the most common misfolded protein responsible for human neurodegenerative diseases. The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease. An increased understanding of the pathway leading from conformational changes in tau protein and tau propagation to neuronal dysfunction, cell death and clinical manifestation will be the key for the development mechanism-based therapeutic strategies for tauopathies...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28784297/the-200-year-journey-of-parkinson-disease-reflecting-on-the-past-and-looking-towards-the-future
#12
Stanley Fahn
It took almost 100 years before a meaningful advance occurred in any basic science understanding of Parkinson disease (PD) following James Parkinson's description in 1817. The Lewy body was described in 1912, and the substantia nigra was found to be depigmented with neuronal loss and gliosis in 1919. The link between dopamine and PD began in 1957, 140 years after Parkinson's Essay. Arvid Carlsson and Oleh Hornykiewicz were the major pioneers. The revolutionary therapeutic breakthrough was the introduction of high dosage levodopa therapy by George Cotzias in 1967...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28780180/neuropathology-of-parkinson-disease
#13
Dennis W Dickson
INTRODUCTION: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD. METHODS: The neuropathologic features of PD are reviewed based upon personal experience and review of the literature. Molecular pathology of PD is summarized from cell biological and animal studies...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28793970/historical-perspective-the-pros-and-cons-of-conventional-outcome-measures-in-parkinson-s-disease
#14
Shen-Yang Lim, Ai Huey Tan
BACKGROUND: Conventional outcome measures (COMs) in Parkinson's disease (PD) refer to rating scales, questionnaires, patient diaries and clinically-based tests that do not require specialized equipment. METHODS: It is timely at this juncture - as clinicians and researchers begin to grapple with the "invasion" of digital technologies - to review the strengths and weaknesses of these outcome measures. RESULTS: This paper discusses advances (including an enhanced understanding of PD itself, and the development of clinimetrics as a field) that have led to improvements in the COMs used in PD; their strengths and limitations; and factors to consider when selecting and using a measuring instrument...
July 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28774469/thalamic-neurometabolic-alterations-in-tremulous-parkinson-s-disease-a-preliminary-proton-mr-spectroscopy-study
#15
Gaetano Barbagallo, Gennarina Arabia, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Maria Salsone, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The objective of this study was to investigate the thalamic biochemical changes in tremor-dominant Parkinson's disease (tPD) patients in comparison with essential tremor with resting tremor (rET) patients, by using proton MR spectroscopy ((1)H-MRS). METHODS: Fourteen tPD patients, 12 rET patients and 10 controls participated in this study. All patients underwent dopamine transporter single-photon emission computed tomography (DAT-SPECT) with (123)I-ioflupane, and a short-echo single-voxel (1)H-MRS on a 3T scanner...
July 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28780181/white-matter-tract-alterations-in-parkinson-s-disease-patients-with-punding
#16
Elisa Canu, Federica Agosta, Vladana Markovic, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess brain white matter tract alterations in patients with Parkinson's disease and punding (PD-punding) compared with controls and PD cases without any impulsive-compulsive behaviour. METHODS: Forty-nine PD patients (21 PD-punding and 28 PD with no impulsive-compulsive behaviours) and 28 controls were consecutively recruited. Clinical, cognitive and psychopathological evaluations were performed. Diffusion tensor MRI metrics of the main white matter tracts were assessed using a tractography approach...
July 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28760592/promising-rodent-models-in-parkinson-s-disease
#17
Paola Imbriani, Giuseppe Sciamanna, Massimo Santoro, Tommaso Schirinzi, Antonio Pisani
BACKGROUND: In the past decade, the study of the pathogenic mechanisms underlying neurodegeneration in Parkinson's disease (PD) has revealed a genetic component, often associated with a number of environmental risk factors. Animal models have improved our understanding of disease pathogenesis, providing significant insights into the understanding of novel molecular pathways. Each model has its own specific features and limitations, and the choice of the most appropriate one depends on the specific question that has to be answered...
July 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28764914/breaking-down-autophagy-and-the-ubiquitin-proteasome-system
#18
Shinae Jung, Yuhyun Chung, Young J Oh
Autophagy is an evolutionarily conserved catabolic process that is involved in cellular homeostasis and stress responses. Although basal levels of autophagy are essential for cellular homeostasis, dysregulated autophagy is linked to neurodegeneration. Recent studies using genetic or neurotoxin-based models of Parkinson's disease (PD) detect autophagy. We demonstrate that neurotoxins induce autophagy in dopaminergic neuronal cell line and primary cultured neurons. Based on previous reports, including ones from our laboratory, which show that elevated reactive oxygen species (ROS) and cytosolic calcium are implicated in dopaminergic neurodegeneration, we reasoned that these triggers may play critical roles in determining dysregulated autophagy...
July 26, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28760593/integration-of-technology-based-outcome-measures-in-clinical-trials-of-parkinson-and-other-neurodegenerative-diseases
#19
Carlo Alberto Artusi, Murli Mishra, Patricia Latimer, Joaquin A Vizcarra, Leonardo Lopiano, Walter Maetzler, Aristide Merola, Alberto J Espay
INTRODUCTION: We sought to review the landscape of past, present, and future use of technology-based outcome measures (TOMs) in clinical trials of neurodegenerative disorders. METHODS: We systematically reviewed PubMed and ClinicalTrials.gov for published and ongoing clinical trials in neurodegenerative disorders employing TOMs. In addition, medical directors of selected pharmaceutical companies were surveyed on their companies' ongoing efforts and future plans to integrate TOMs in clinical trials as primary, secondary, or exploratory endpoints...
July 26, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28802759/sensor-assisted-self-management-in-parkinson-s-disease-a-feasibility-study-of-ambulatory-posture-detection-and-feedback-to-treat-stooped-posture
#20
E E H van Wegen, C J T de Goede, G Kwakkel, J van Kordelaar
INTRODUCTION: A stooped posture is one of the characteristic motor symptoms of patients with Parkinson's disease, and has been linked to impairments in daily activities and quality of life. We aimed to test the efficacy, safety, practical utility and user-friendliness of a posture correction and vibrotactile trunk angle feedback device (the UpRight) in the home setting of patients with Parkinson's disease with a stooped posture. It was hypothesized that ambulatory use of the UpRight would be safe, feasible and result in a less stooped posture, i...
July 25, 2017: Parkinsonism & related Disorders
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