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Parkinsonism & related Disorders

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https://www.readbyqxmd.com/read/28993094/characterization-of-diplopia-in-non-demented-patients-with-parkinson-s-disease
#1
Katharina A Schindlbeck, Shideh Schönfeld, Wanda Naumann, David J Friedrich, André Maier, Charlotte Rewitzer, Fabian Klostermann, Frank Marzinzik
INTRODUCTION: Although diplopia is considered a frequent symptom of Parkinson's disease (PD), little is known about its clinical manifestation, associated mechanisms and treatment. Here we characterized binocular diplopia in non-demented PD patients in an interdisciplinary setting. METHODS: PD patients were prospectively screened for diplopia, visual hallucinations, problems with spatial perception, contrast sensitivity, presence of blurred vision, and history of ophthalmological comorbidities via interview...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28988683/smoking-and-age-at-onset-of-both-motor-and-non-motor-symptoms-in-parkinson-s-disease
#2
Angelo Fabio Gigante, Tommaso Martino, Giovanni Iliceto, Giovanni Defazio
INTRODUCTION: Several evidence suggest that smoking may decrease the risk of Parkinson's disease and is associated with an older age-at-onset of motor signs. The relation between smoking and age-at-onset of non-motor symptoms has never been analyzed. Objective of the study is to evaluate whether smoking habit and pack-years of smoking are associated with a delay of age-at-onset of motor signs, and of some non-motor symptoms. METHODS: The study population consisted of 262 consecutive parkinsonian patients...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28982612/brain-regional-iron-contents-in-progressive-supranuclear-palsy
#3
Seung Ha Lee, Chul Hyoung Lyoo, Sung Jun Ahn, Juha O Rinne, Myung Sik Lee
INTRODUCTION: To determine motor-related brain regions in which iron contents correlate with the degree of motor deficits of progressive supranuclear palsy (PSP). METHODS: Twenty-four patients with probable PSP and 20 controls were included. Using a 3.0T magnetic resonance imaging scanner, R2* values were measured in the putamen, globus pallidus (GP), substantia nigra (SN), subthalamic nucleus, and dentate nucleus. After adjustment for disease duration and age at examination, correlations between regional brain R2* values and Unified Parkinson Disease Rating Scale (UPDRS) total motor scores or subscores for bradykinesia, rigidity, tremor, or axial motor deficits were investigated...
September 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28965872/validation-of-the-hebrew-version-of-the-movement-disorder-society-unified-parkinson-s-disease-rating-scale
#4
Jennifer Zitser, Chava Peretz, Aya Ber David, Herzl Shabtai, Adi Ezra, Meir Kestenbaum, Marina Brozgol, Alina Rosenberg, Talia Herman, Yakov Balash, Avi Gadoth, Avner Thaler, Glenn T Stebbins, Christopher G Goetz, Barbara C Tilley, Sheng T Luo, Yuanyuan Liu, Nir Giladi, Tanya Gurevich
BACKGROUND: The Movement Disorders Society (MDS) published the English new Unified Parkinson's Disease Rating Scale (MDS-UPDRS) as the official benchmark scale for Parkinson's disease (PD) in 2008. We aimed to validate the Hebrew version of the MDS-UPDRS, explore its dimensionality and compare it to the original English one. METHODS: The MDS-UPDRS questionnaire was translated to Hebrew and was tested on 389 patients with PD, treated at the Movement Disorders Unit at Tel-Aviv Medical Center...
September 24, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28964628/structural-connectome-alterations-in-prodromal-and-de-novo-parkinson-s-disease-patients
#5
Ming-Ching Wen, Hannah S E Heng, Jung-Lung Hsu, Zheyu Xu, Gerald M Liew, Wing Lok Au, Ling Ling Chan, Louis C S Tan, Eng King Tan
BACKGROUND: Although the clinical signs of prodromal Parkinson's disease (PD) have been identified, little is known about the neural features of the prodromal phase of PD (proPD). The aim of this study was to examine the structural network alterations from healthy aging to proPD and to early PD. METHODS: 181 non-demented and non-depressed participants comprising 55 healthy controls (HCs), 20 proPDs, and 106 de novo PD patients (dPDs) were included in the study and underwent clinical assessment and diffusion tensor imaging scanning...
September 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28947073/expanding-the-phenotype-of-sca19-22-parkinsonism-cognitive-impairment-and-epilepsy
#6
Vincent Huin, Isabelle Strubi-Vuillaume, Kathy Dujardin, Marine Brion, Marie Delliaux, Delphine Dellacherie, Jean-Christophe Cuvellier, Jean-Marie Cuisset, Audrey Riquet, Caroline Moreau, Luc Defebvre, Bernard Sablonnière, David Devos
INTRODUCTION: Spinocerebellar ataxia types 19 and 22 (SCA19/22) are rare conditions in which relatively isolated cerebellar involvement is frequently associated with cognitive impairment. Here, we report on new clinical features and provide details of the cognitive profile in two SCA19/22 families. METHODS: Two families displaying an autosomal-dominant form of cerebellar ataxia underwent clinical examinations and genetic testing. RESULTS: In addition to the classical clinical features of SCA, a wide spectrum of cognitive disorders (including visuospatial impairments) was observed...
September 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28958832/gch1-mutations-are-common-in-serbian-patients-with-dystonia-parkinsonism-challenging-previously-reported-prevalence%C3%A2-rates-of-dopa-responsive-dystonia
#7
Valerija Dobričić, Aleksandra Tomić, Vesna Branković, Nikola Kresojević, Milena Janković, Ana Westenberger, Vedrana Milić Rašić, Christine Klein, Ivana Novaković, Marina Svetel, Vladimir S Kostić
BACKGROUND: GTP cyclohydrolase 1-deficient DOPA-responsive dystonia, caused by autosomal dominant mutation in the gene coding for GTP cyclohydrolase 1, is a rare disorder with a reported prevalence of 0.5 per million. A correct diagnosis of DRD is crucial, given that this is an exquisitely treatable neurogenetic disorder. Although genetic testing is now widely available, we hypothesize that DRD is still underdiagnosed and its prevalence underestimated. METHODS: Molecular genetic analysis of the GCH1 gene was performed in a representative cohort of 47 Serbian patients with clinical features of DRD and in their 16 available relatives...
September 18, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28941828/fatigue-correlates-with-lrrk2-g2385r-variant-in-chinese-parkinson-s-disease-patients
#8
Rao Fu, Shi-Shuang Cui, Juan-Juan Du, Ya-Chao He, Chao Gao, Pei Huang, Yi-Wei Qian, Xiao-Guang Luo, Sheng-Di Chen
INTRODUCTION: Fatigue is common in patients with Parkinson's disease (PD). The leucine-rich repeat kinase 2 (LRRK2) G2385R variant predisposes individuals to develop PD in China. The aim of this study was to evaluate whether the LRRK2 G2385R variant is associated with fatigue in patients with PD. METHODS: Fatigue was evaluated by the Parkinson Fatigue Scale (PFS) in 329 PD patients and 180 controls, a cut-off score of ≥3.3 was used to define the presence of fatigue...
September 18, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28941829/the-clinical-features-and-functional-impact-of-valproate-induced-tremor
#9
Marlene Alonso-Juarez, Diego Torres-Russotto, Paulina Crespo-Morfin, José Fidel Baizabal-Carvallo
BACKGROUND: Tremor is a known side-effect of anticonvulsants, particularly of valproate. However, there is a dearth of information regarding detailed clinical features and functional impact of valproate-induced tremor. METHODS: We studied a cohort of patients treated with anticonvulsants for neurological disorders, through blinded evaluations using the Clinical Rating Scale for Tremor (CRST); we compared the frequency, severity and functional impact of drug-induced tremor between patients treated with valproate and those treated with other anticonvulsants...
September 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28935191/circadian-rhythm-and-autonomic-dysfunction-in-presymptomatic-and-early-huntington-s-disease
#10
Elena Bellosta Diago, Jesús Pérez Pérez, Sonia Santos Lasaosa, Alejandro Viloria Alebesque, Saül Martínez Horta, Jaime Kulisevsky, Javier López Del Val
INTRODUCTION: Sleep and circadian rhythm disturbances are common in patients with neurodegenerative diseases such as Huntington's disease (HD). The aim of this study was to evaluate variability in circadian blood pressure (BP) to determine the association between abnormal circadian BP and sleep quality in patients with HD. METHODS: Cross-sectional, multicenter study of 38 HD mutation carriers (23 premanifest and 15 early stage patients) who were compared to 38 age- and sex-matched controls...
September 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28964627/pallidal-dbs-for-dystonia-in-the-age-of-personalized-medicine
#11
LETTER
K Amande M Pauls, Joachim K Krauss, Andrea A Kühn, Elena Moro, Gereon R Fink, Jens Volkmann, Lars Timmermann
In response to the correspondence by Albanese and co-workers, we discuss etiology as a factor predicting outcome of pallidal DBS in dystonia, reanalysing our dataset on causes of non-response to pallidal DBS in isolated dystonia by looking only at patients with a diagnosis of idiopathic dystonia at time of surgery.
September 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28941827/failure-of-pallidal-deep-brain-stimulation-in-dyt12-atp1a3-dystonia
#12
LETTER
Alberto Albanese, Mario Di Giovanni, Paolo Amami, Stefania Lalli
No abstract text is available yet for this article.
September 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28928050/predictors-of-onset-of-psychosis-in-patients-with-parkinson-s-disease-who-gets-it-early
#13
Abhishek Lenka, Lija George, Shyam Sundar Arumugham, Shantala Hegde, Venkateswara Reddy, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Psychosis is one of the common non-motor symptoms of PD, which substantially worsens the quality of life. Hence, it is important to identify factors that are associated with early onset of psychosis in PD. In order to identify those factors, the current study aims to compare various demographic and clinical features of PD patients with early and late onset psychosis. METHODOLOGY: In this prospective case-control study, 51 consecutive patients with PD having psychosis (PDP) were recruited...
September 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28919173/trigeminal-system-in-parkinson-s-disease-a-potential-avenue-to-detect-parkinson-specific-olfactory-dysfunction
#14
Cécilia Tremblay, Pascali Durand Martel, Johannes Frasnelli
BACKGROUND: Olfactory dysfunction (OD) is very frequent in Parkinson's disease (PD) and observed years before diagnosis. The trigeminal system, a chemosensory system allowing for the perception of spiciness, freshness, etc., is intimately connected to the olfactory system and although usually reduced in OD the trigeminal system is not well characterized in PD. We hypothesize that measuring trigeminal sensitivity potentially allows to discriminate between OD due to PD and OD due to other causes to potentially help the development of an early diagnostic tool...
September 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28917824/parkinson-s-disease-susceptibility-variants-and-severity-of-lewy-body-pathology
#15
Michael G Heckman, Koji Kasanuki, Nancy N Diehl, Shunsuke Koga, Alexandra Soto, Melissa E Murray, Dennis W Dickson, Owen A Ross
INTRODUCTION: Meta-analyses of genome-wide association studies (GWAS) have established common genetic risk factors for clinical Parkinson's disease (PD); however, associations between these risk factors and quantitative neuropathologic markers of disease severity have not been well-studied. This study evaluated associations of nominated variants from the most recent PD GWAS meta-analysis with Lewy body disease (LBD) subtype (brainstem, transitional, or diffuse) and pathologic burden of LB pathology as measured by LB counts in five cortical regions in a series of LBD cases...
September 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28917823/on-the-role-of-visual-electrophysiology-in-parkinson-s-disease
#16
LETTER
Fabio Bandini
No abstract text is available yet for this article.
September 8, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28919149/response-to-on-the-role-of-visual-electrophysiology-in-parkinson-s-disease
#17
LETTER
Janssen S, M S Ekker, W Poewe, R J A van Wezel, J Nonnekes, B R Bloem
No abstract text is available yet for this article.
September 7, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28923295/globular-glial-tauopathy-presenting-as-non-fluent-agrammatic-variant-primary-progressive-aphasia-with-chorea
#18
LETTER
Eun-Joo Kim, Myung Jun Lee, Jae-Hyeok Lee, Young Min Lee, Jin-Hong Shin, Myung-Jun Shin, Kyung-Un Choi, Na-Yeon Jung, Kyoungjune Pak, Chungsu Hwang, Jae Woo Ahn, Suk Sung, Salvatore Spina, Lea T Grinberg, William W Seeley, Gi Yeong Huh
No abstract text is available yet for this article.
September 6, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28923293/two-polysomnographic-features-of-rem-sleep-behavior-disorder-clinical-variations-insight-for-parkinson-s-disease
#19
Yun Shen, Yong-Ping Dai, Yi Wang, Jie Li, Kang-Ping Xiong, Cheng-Jie Mao, Jun-Ying Huang, Wei-Feng Luo, Chun-Feng Liu
INTRODUCTION: Loss of REM sleep muscle atonia (RWA) and dream-enactment behavior (DEB) are two associated features of REM sleep behavior disorder (RBD), which is frequently associated with Parkinson's disease (PD). Few studies have examined both DEB and RWA simultaneously in patients with PD. This study aimed to evaluate relationships between RWA, DEB and clinical characteristics of PD. METHODS: We conducted overnight polysomnography in 145 patients with PD. DEB (motor behaviors and/or vocalizations during REM) and increased RWA (IRWA; tonic and phasic chin EMG density ≥ 30% and ≥15%, respectively) were identified...
September 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28923294/fundamental-limit-of-alpha-synuclein-pathology-in-gastrointestinal-biopsy-as-a-pathologic-biomarker-of-parkinson-s-disease-comparison-with-surgical-specimens
#20
Chaewon Shin, Sung-Hye Park, Ji Young Yun, Jung Hwan Shin, Han-Kwang Yang, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Guangxun Shen, Yoon Kim, Han-Joon Kim, Beomseok Jeon
OBJECTIVE: Alpha-synuclein (AS) accumulation identified by immunohistochemistry (IHC) of gastrointestinal (GI) tract biopsies is considered as a potential pathologic biomarker for Parkinson's disease (PD). We compared AS IHC findings in biopsy specimens and surgically resected full-depth specimens to examine the reliability of GI tract biopsies. METHODS: We included patients with PD who had undergone operation of the GI tract for treatment of tumors. Controls were matched with age at operation, gender, and surgical resection site...
September 4, 2017: Parkinsonism & related Disorders
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