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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/28875514/cancer-screening-participation-in-schizophrenic-outpatients-and-the-influence-of-their-functional-disability-on-the-screening-rate-a-cross-sectional-study-in-japan
#1
Masaki Fujiwara, Masatoshi Inagaki, Naoki Nakaya, Maiko Fujimori, Yuji Higuchi, Chinatsu Hayashibara, Ryuhei So, Kyoko Kakeda, Masafumi Kodama, Yosuke Uchitomi, Norihito Yamada
AIM: The influence of schizophrenic patients' functional disability on cancer screening participation worldwide is unclear. There are few findings on the disparities in schizophrenic patients' participation in cancer screening programs in Asia. The aim of this study was to investigate the screening rate and the associations between screening and symptom severity/functional disability in patients with schizophrenia. METHODS: This cross-sectional study was conducted in a psychiatric hospital outpatient clinic in Japan...
September 5, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28869354/working-memory-network-alterations-in-high-functioning-adolescents-with-an-autism-spectrum-disorder
#2
Evelien M Barendse, Lisanne J Schreuder, Geert Thoonen, Marc P H Hendriks, Roy P C Kessels, Walter H Backes, Albert P Aldenkamp, Jacobus F A Jansen
AIM: People with autism spectrum disorder (ASD) typically have deficits in the working memory (WM) system. Working memory is found to be an essential chain in successfully navigating in the social world. We hypothesize that brain networks for WM have an altered network integrity in ASD compared to controls. METHODS: 13 adolescents (1 female) with autistic disorder (n = 1), Asperger's disorder (n = 7), and pervasive developmental disorder not otherwise specified (n = 5), and 13 typically developing control adolescents (1 female) participated in this study...
September 4, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28858412/a-randomized-double-blind-placebo-controlled-8-week-trial-of-the-efficacy-safety-and-tolerability-of-5-10-and-20-mg-day-vortioxetine-in-adults-with-major-depressive-disorder
#3
Akira Nishimura, Yutaka Aritomi, Kiyofumi Sasai, Tadayuki Kitagawa, Atul R Mahableshwarkar
AIM: This study assessed the efficacy and safety of vortioxetine in adults with major depressive disorder. METHODS: In this double-blind, placebo-controlled study, 600 patients with major depressive disorder were randomly assigned (1:1:1:1) to receive vortioxetine 5, 10, or 20 mg, or placebo once daily for 8 weeks. The primary endpoint was change from baseline in Montgomery-Åsberg Depression Rating Scale total score at week 8, evaluated by the last observation carried forward method...
August 31, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28853197/two-cases-of-musical-hallucination-successfully-treated-with-quetiapine
#4
LETTER
Hideaki Kitamura, Mami Saito, Toshiyuki Someya
Individuals suffering from musical hallucination (MH) experience hearing repeated music or melodies in the absence of acoustic stimuli. Older women with auditory difficulties also report hearing familiar songs.
August 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28815874/white-matter-alterations-associate-with-onset-symptom-dimension-in-obsessive-compulsive-disorder
#5
Irene Bollettini, Mario Gennaro Mazza, Laura Muzzarelli, Sara Dallaspezia, Sara Poletti, Benedetta Vai, Enrico Smeraldi, Francesco Benedetti
AIM: The high heterogeneity of obsessive-compulsive disorder is best described by a multidimensional model involving symptom dimensions. Our study aimed at investigating white matter alterations associated with obsessive-compulsive disorder focusing on the impact of long lasting effect of symptom dimensions assessed at onset of the illness. Furthermore, we investigate white matter alterations associated with this disorder controlling for the impact of medications and for the prevailing current symptom dimension...
August 16, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28776869/a-possibility-of-over-diagnosis-of-bipolar-disorder-due-to-near-infrared-spectroscopy
#6
LETTER
Tadafumi Kato, Naomi Sakai, Yoshinori Watanabe, Soichiro Nomura
In Japan, near-infrared spectroscopy (NIRS) (optical topography) was recently approved for health insurance as an auxiliary laboratory test for differential diagnosis of depressive state of bipolar disorder (BD) and schizophrenia from that of major depression.
August 4, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28767198/optimal-cut-off-score-of-the-edinburgh-postnatal-depression-scale-for-major-depressive-episode-during-pregnancy-in-japan
#7
Kentaro Usuda, Daisuke Nishi, Emi Okazaki, Miyuki Makino, Yo Sano
AIM: Depression during pregnancy adversely affects both mother and child. As antenatal depression is a predictor of postnatal depression, early detection might prevent postnatal depression. The Edinburgh Postnatal Depression Scale (EPDS) is frequently used during the perinatal period, but the cut-off score during pregnancy has not been verified for the Japanese population. We aimed to clarify the optimal EPDS cut-off score in mid-pregnancy in Japan. METHODS: We recruited pregnant women aged 20 years or older at 12-24 weeks of gestation and those who scored ≥ 9 on the EPDS were invited to participate in this study...
August 2, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28755401/association-between-the-scores-of-the-japanese-version-of-the-brief-assessment-of-cognition-in-schizophrenia-and-whole-brain-structure-in-patients-with-chronic-schizophrenia-a-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#8
Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Kotaro Hattori, Hiroshi Kunugi
AIM: The brief assessment of cognition in schizophrenia (BACS) is a concise tool designed to evaluate cognitive deficits in schizophrenia. We examined the possible association between BACS scores and whole-brain structure, as observed using magnetic resonance imaging (MRI) with a relatively large sample. METHODS: The study sample comprised 116 patients with schizophrenia (mean age, 39.3 ± 11.1 years; 66 men) and 118 healthy controls (40.0 ± 13.6; 58 men) who completed the Japanese version of the BACS (BACS-J)...
July 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28715136/underweight-and-hypoalbuminemia-as-risk-indicators-for-mortality-among-psychiatric-patients-with-medical-comorbidities
#9
Takahiro Haga, Kae Ito, Masahiro Ono, Jiro Maruyama, Mari Iguchi, Hitoe Suzuki, Eiji Hayashi, Kentaro Sakashita, Tomoko Nagao, Shohei Ikemoto, Asuka Okaniwa, Makiko Kitami, Eriko Inuo, Koichiro Tatsumi
AIM: Medical comorbidities are a major cause of death among patients with mental illness. The purpose of this study was to clarify the risk factors for mortality among psychiatric patients with medical comorbidities. METHODS: We retrospectively reviewed the clinical files of patients transferred to Tokyo Metropolitan Matsuzawa Hospital from a psychiatric hospital to treat medical comorbidities during the 3-year period from January 2014 to December 2016. We analyzed the clinical differences between the expired and alive patients...
July 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28692185/an-application-of-functional-near-infrared-spectroscopy-as-supplementary-examination-for-diagnosis-of-clinical-stages-of-psychosis-spectrum
#10
Shinsuke Koike, Satomura Yoshihiro, Shingo Kawasaki, Yukika Nishimura, Akihide Kinoshita, Hanako Sakurada, Mika Yamagishi, Eriko Ichikawa, Jun Matsuoka, Naohiro Okada, Ryu Takizawa, Kiyoto Kasai
AIM: Research efforts aiming at neuroimaging-aided differential diagnosis for psychiatric disorders have been progressing rapidly. A previous multisite study has developed supplementary diagnostic system using functional near-infrared spectroscopy (fNIRS) that can be easily applied to clinical settings. However, few neuroimaging biomarkers have been developed for psychosis spectrum with various clinical stages. METHODS: We employed the fNIRS as a clinical examination device for 143 participants, comprising 47 ultra-high risk (UHR) individuals, 30 patients with first-episode psychosis (FEP), 34 patients with chronic schizophrenia (ChSZ), and 33 healthy controls, who were independent of the previous study...
July 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28675555/rna-sequencing-in-postmortem-human-brains-of-neuropsychiatric-disorders
#11
Chun Wu, Raphael M Bendriem, Susanna P Garamszegi, Lei Song, Chun-Ting Lee
RNA sequencing (RNA-Seq), a revolutionary tool for transcriptome profiling, is becoming increasingly important for neuroscientists in studying the transcriptional landscape of the human brain. Studies using this next generation sequencing (NGS) technique have already revealed novel insights into the complexity of neurons in the human brain and pathogenesis of complex neurological diseases. In clinical neuroscience, RNA-Seq provides exciting opportunities for improving diagnosis and treatment of neurological diseases by facilitating the development of pharmacotherapies able to modulate gene expression...
July 4, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28657695/rare-pdcd11-variations-are-not-associated-with-risk-of-schizophrenia-in-japan
#12
Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya
AIM: Rare gene variations are thought to confer substantial risk for schizophrenia. We performed a three-stage study to identify rare variations that have a strong impact on the risk of developing schizophrenia. METHODS: In the first stage, we prioritized rare missense variations using whole-exome sequencing (WES) data from three families, consisting of a proband, an affected sibling, and parents. In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients...
June 28, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28657683/association-between-social-functioning-and-prefrontal-cortex-function-during-a-verbal-fluency-task-in-schizophrenia-a-near-infrared-spectroscopic-study
#13
Masashi Itakura, Shenghong Pu, Hiroaki Ohdachi, Hiroshi Matsumura, Katsutoshi Yokoyama, Izumi Nagata, Masaaki Iwata, Koichi Kaneko
AIM: Impaired social functioning is a common characteristic of patients with schizophrenia. Social functioning requires the complex operation of various executive functions. Deficits in the prefrontal cortex (PFC) have been implicated in executive dysfunction. Here we aimed to clarify the relationship between subjectively and objectively assessed social functioning, and their associations with PFC function in patients with schizophrenia. METHODS: Twenty-three patients and twenty-two age- and sex-matched healthy controls (HCs) were assessed...
June 28, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28393474/application-of-induced-pluripotent-stem-cells-to-understand-neurobiological-basis-of-bipolar-disorder-and-schizophrenia
#14
Yao-Nan Liu, Si-Yao Lu, Jun Yao
The etiology of neuropsychiatric disorders, such as schizophrenia and bipolar disorder, usually involves complex combinations of genetic defects/variations and environmental impacts, which hindered, for a long time, research efforts based on animal models and patients' non-neuronal cells or post-mortem tissues. However, the development of human induced pluripotent stem cell (iPSC) technology by the Yamanaka group was immediately applied to establish cell research models for neuronal disorders. Since then, techniques to achieve highly efficient differentiation of different types of neural cells following iPSC modeling have made much progress...
September 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28776862/polg1-mutations-in-bipolar-disorders
#15
LETTER
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
August 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28776861/polymerase-gamma-in-bipolar-disorder-it-s-complicated
#16
EDITORIAL
Christine Konradi
No abstract text is available yet for this article.
August 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28670828/retraction-statement-long-term-efficacy-and-safety-of-blonanserin-in-patients-with-first-episode-schizophrenia-a-1-year-open-label-trial-by-y-ninomiya-s-miyamoto-t-tenjin-s-ogino-n-miyake-y-kaneda-t-sumiyoshi-and-n-yamaguchi
#17
https://www.readbyqxmd.com/read/28670827/toward-the-inclusion-of-gaming-disorder-in-icd-11
#18
EDITORIAL
Susumu Higuchi
No abstract text is available yet for this article.
July 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27649380/typology-of-internet-gaming-disorder-and-its-clinical-implications
#19
REVIEW
Seung-Yup Lee, Hae Kook Lee, Hyekyung Choo
Various perspectives exist regarding Internet gaming disorder. While the concept of behavioral addiction is gaining recognition, some view the phenomenon as merely excessive indulgence in online pastimes. Still, in recent years, complaints from patients or their family members about problems related to Internet use, particularly Internet gaming, have become more common. However, the clinical picture of Internet gaming disorder could be obscured by its heterogeneous manifestations with other intertwined factors, such as psychiatric comorbidities, neurodevelopmental factors, sociocultural factors, and game-related factors, which may influence the pathogenesis as well as the clinical course...
July 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27450920/neurobiological-findings-related-to-internet-use-disorders
#20
REVIEW
Byeongsu Park, Doug Hyun Han, Sungwon Roh
In the last 10 years, numerous neurobiological studies have been conducted on Internet addiction or Internet use disorder. Various neurobiological research methods - such as magnetic resonance imaging; nuclear imaging modalities, including positron emission tomography and single photon emission computed tomography; molecular genetics; and neurophysiologic methods - have made it possible to discover structural or functional impairments in the brains of individuals with Internet use disorder. Specifically, Internet use disorder is associated with structural or functional impairment in the orbitofrontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, and posterior cingulate cortex...
July 2017: Psychiatry and Clinical Neurosciences
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