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Psychiatry and Clinical Neurosciences

Takashi Tomita, Hidekazu Goto, Takeshi Chiba, Tomohiko Tairabune, Tadashi Yoshida, Katsuya Tanaka, Kenzo Kudo, Yukinao Kohda
No abstract text is available yet for this article.
October 15, 2016: Psychiatry and Clinical Neurosciences
Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Jun Aida, Ichiro Tsuji, Atsushi Hozawa, Hiroaki Tomita
AIM: Social capital has been considered an important factor to affect mental-health outcomes such as psychological distress in post-disaster settings. Although disaster-related house-condition and displacement could affect both social capital and psychological distress, limited studies have investigated interactions. This study aimed to examine the association between social capital and psychological distress taking into consideration the interaction of disaster-related house-condition after the Great East Japan Earthquake of 2011...
October 15, 2016: Psychiatry and Clinical Neurosciences
Kazuhiko Yamamuro, Toyosaku Ota, Junzo Iida, Naoko Kishimoto, Yoko Nakanishi, Toshifumi Kishimoto
AIMS: Increasing clinical evidence points to impulsivity as a symptom of obsessive-compulsive disorder (OCD). However, little is known about its persistence over time. METHODS: In this study, we evaluated the performance of 12 pediatric patients with OCD on the Stroop color-word task, which assesses impulsivity and compared this with age- and sex-matched controls. In parallel, we measured changes in hemodynamic responses during the task, using near-infrared spectroscopy...
October 4, 2016: Psychiatry and Clinical Neurosciences
Kazuko Kato, Seiko Miyata, Motoo Ando, Hiroki Matsuoka, Fumihiko Yasuma, Kunihiro Iwamoto, Naoko Kawano, Masahiro Banno, Norio Ozaki, Akiko Noda
AIMS: Short sleep duration is a risk factor for cardiovascular diseases. Cerebral blood flow and its regulation are affected by pathological conditions commonly observed in the elderly population, such as dementia, atherosclerosis, diabetes mellitus, stroke and hypertension. The purpose of this study was to examine the influence of sleep duration on cortical oxygenated hemoglobin (OxyHb) using near-infrared spectroscopy (NIRS). METHODS: Seventy-three individuals (age, 70...
October 3, 2016: Psychiatry and Clinical Neurosciences
Glenda M MacQueen, Katherine A Memedovich
Cognitive dysfunction is a recognized feature of mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). Cognitive impairment is associated with poor overall functional outcome and is therefore an important feature of illness to optimize for patients' occupational and academic outcomes. While generally people with BD appear to have a greater degree of cognitive impairment than those with MDD, direct comparisons of both patient groups within a single study are lacking. There are a number of methods for the assessment of cognitive function, but few are currently used in clinical practice...
September 29, 2016: Psychiatry and Clinical Neurosciences
Yu Funahashi, Yuta Yoshino, Kiyohiro Yamazaki, Yoko Mori, Takaaki Mori, Yuki Ozaki, Tomoko Sao, Shinichiro Ochi, Jun-Ichi Iga, Shu-Ichi Ueno
AIM: It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap with both Alzheimer's disease (AD) and Parkinson's disease (PD). The α-synuclein protein is a major component of Lewy bodies, and accumulation of α-synuclein aggregates causes synaptic dysfunction in DLB. Epigenetic changes at the synuclein alpha gene (SNCA) may be involved in DLB pathogenesis. METHODS: We examined DNA methylation rates at 10 CpG sites located in intron 1 of SNCA and SNCA mRNA expression in peripheral leukocytes to compare DLB patients (n = 20; 9 males, 11 females; age = 78...
September 29, 2016: Psychiatry and Clinical Neurosciences
Yuki Kageyama, Takaoki Kasahara, Hiromasa Morishita, Nobuko Mataga, Yasuhiko Deguchi, Munehide Tani, Kenji Kuroda, Kotaro Hattori, Sumiko Yoshida, Koki Inoue, Tadafumi Kato
AIMS: There is an urgent need for diagnostic biomarkers of bipolar disorder (BD) and schizophrenia (SZ); however, confounding effects of medication on hamper biomarker discovery. In this study, we conducted metabolome analyses to identify novel plasma biomarkers in drug-free patients with BD and SZ. METHODS: We comprehensively analyzed plasma metabolites using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) in patients with SZ (n = 17), BD (n = 6), and major depressive disorder (n = 9), who had not received psychotropics for at least two weeks, and in matched healthy controls (n = 19)...
September 27, 2016: Psychiatry and Clinical Neurosciences
Kentaro Morita, Kenichiro Miura, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Masao Iwase, Kiyoto Kasai, Ryota Hashimoto
AIM: Studies have shown that eye movement abnormalities are possible neurophysiological biomarkers for schizophrenia. The aim of this study is to investigate the utility of eye movement abnormalities in identifying patients with schizophrenia from healthy controls. METHODS: Eighty-five patients with schizophrenia and 252 healthy controls participated in this study. Eye movement measures were collected from free viewing, fixation stability, and smooth pursuit tests...
September 27, 2016: Psychiatry and Clinical Neurosciences
Keith Fluegge
No abstract text is available yet for this article.
September 27, 2016: Psychiatry and Clinical Neurosciences
Mostafa Mostafazadeh-Bora, Amin Zarghami, Mohsen Shahriari
No abstract text is available yet for this article.
September 27, 2016: Psychiatry and Clinical Neurosciences
Seung-Yup Lee, Hae Kook Lee, Hyekyung Choo
Various perspectives exist regarding Internet gaming disorder. While the concept of behavioral addiction is gaining recognition, some view the phenomenon as merely excessive indulgence in online pastimes. Still, in recent years, complains from patients or their family members about problems related to Internet use, particularly Internet gaming, have become more common. However, the clinical picture of Internet gaming disorder could be obscured by its heterogeneous manifestations with other intertwined factors, such as psychiatric comorbidities, neurodevelopmental factors, socio-cultural factors and game-related factors, that may influence the pathogenesis as well as the clinical course...
September 20, 2016: Psychiatry and Clinical Neurosciences
José Eriton Gomes Cunha, João Ricardo Mendes Oliveira
No abstract text is available yet for this article.
September 13, 2016: Psychiatry and Clinical Neurosciences
Chanchan Shen, Jiawei Wang, Guorong Ma, Qisha Zhu, Hongjian He, Qiuping Ding, Hongying Fan, Yanxia Lu, Wei Wang
AIM: The purpose of current study is to explore the cerebral areas involved in nightmare disorder. METHODS: Fifteen nightmare disorder patients and 15 healthy volunteers were invited to undergo tests of the resting-state functional magnetic resonance imaging and the Nightmare Experience Questionnaire. RESULTS: The nightmare disorder patients scored higher on Physical Effect and Horrible Stimulation scales, had higher values of regional homogeneity in clusters within the left anterior cingulate cortex and right inferior parietal lobule, and lower regional homogeneity values within left superior and inferior frontal gyri and bilateral middle occipital gyri...
September 9, 2016: Psychiatry and Clinical Neurosciences
Masaru Tateno, Alan R Teo, Tomohiro Shirasaka, Masaya Tayama, Motoki Watabe, Takahiro A Kato
AIM: Internet addiction (IA), also referred to as internet use disorder, is a serious problem all over the world, especially in Asian countries. Severe IA in students may be linked to academic failure, Attention Deficit Hyperactivity Disorder (ADHD), and forms of social withdrawal such as hikikomori. In this study, we performed a survey to investigate the relation between IA and ADHD symptoms among college students. METHODS: Severity of IA and ADHD traits were assessed by self-report scales...
August 30, 2016: Psychiatry and Clinical Neurosciences
Toshihiko Matsumoto, Hisateru Tachimori, Ayumi Takano, Yuko Tanibuchi, Daisuke Funada, Kiyoshi Wada
AIMS: The aim of this study was to examine changes in the psychosocial backgrounds and clinical features of patients with psychiatric disorders associated with the new psychoactive substances (NPS) between 2012 and 2014 in Japan. METHODS: Clinical features of patients with NPS-related disorders were compared using data from the Nationwide Mental Hospital Surveys on Drug-related Psychiatric Disorders undertaken in 2012 and 2014. NPS patients were compared with a control group, comprising patients with methamphetamine (MAP)-related disorders, using data from the same period...
August 16, 2016: Psychiatry and Clinical Neurosciences
Fanny Aldinger, Thomas G Schulze
OBJECTIVE: The etiology and clinical course of bipolar disorder are considered to be determined by genetic and environmental factors. Although the kindling hypothesis emphasizes the impact of environmental factors on initial onset, their connection to the outcome and clinical course has been poorly established. Hence, there have been numerous research efforts to investigate the impact of environmental factors on the clinical course of illness. Our aim is to outline recent research on the impact of environmental determinants on the clinical course of bipolar disorder...
August 8, 2016: Psychiatry and Clinical Neurosciences
Akihide Kinoshita, Ryu Takizawa, Noriaki Yahata, Fumitaka Homae, Ryuichiro Hashimoto, Shingo Kawasaki, Yukika Nishimura, Shinsuke Koike, Kiyoto Kasai
AIM: Neurofeedback has been studied with the aim of controlling cerebral activity. Near-infrared spectroscopy is a non-invasive neuroimaging technique used for measuring hemoglobin concentration changes in cortical surface areas with high temporal resolution. Thus, near-infrared spectroscopy may be useful for neurofeedback, which requires real-time feedback of repeated brain activation measurements. However, no study has specifically targeted neurofeedback, using near-infrared spectroscopy, in the frontal pole cortex METHODS: We developed an original near-infrared spectroscopy neurofeedback system targeting the frontal pole cortex...
August 4, 2016: Psychiatry and Clinical Neurosciences
Miho Ota, Hiroaki Hori, Noriko Sato, Fuyuko Yoshida, Kotaro Hattori, Toshiya Teraishi, Hiroshi Kunugi
AIM: The intronic single-nucleotide polymorphisms rs10994336 of the ankyrin 3 gene is one of the genome-wide supported risk variants for bipolar disorder, and the T-allele of rs10761482 is also reported to have relevance to the bipolar disorder. We investigated the effect of ankyrin 3 gene rs10761482 genetic variation on brain structure. METHODS: Subjects were 43 bipolar disorder patients and 229 healthy volunteers. We evaluated the effects of ankyrin 3 gene rs10761482 genetic variation on diagnosis, and of the genotype-by-diagnosis interaction on the brain structure and the degree of age-related brain atrophy on magnetic resonance imaging data evaluated by voxel-based morphometry RESULTS: Bipolar disorder patients showed significantly lower fractional anisotropy value in the bilateral parietal regions, left fronto-occipital fasciculus, and corpus callosum, compared to that of healthy subjects...
August 4, 2016: Psychiatry and Clinical Neurosciences
Sophia Esalatmanesh, Zoha Abrishami, Atefeh Zeinoddini, Fatemeh Rahiminejad, Majid Sadeghi, Mohammad-Reza Najarzadegan, Mohammad-Reza Shalbafan, Shahin Akhondzadeh
AIM: Several lines of evidence implicate glutamatergic dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD), presenting this neurotransmitter as a target for the development of novel pharmacotherapy. The objective of this study was to assess the efficacy of minocycline as an augmentative agent to fluvoxamine in the treatment of patients with OCD. METHODS: One hundred and two patients with the diagnosis of moderate-to-severe OCD were recruited to this study...
August 4, 2016: Psychiatry and Clinical Neurosciences
Jinuk Song, Jeong Ha Park, Doug Hyun Han, Sungwon Roh, Ji Hyun Son, Tae Young Choi, Hyuk Lee, Tae Ho Kim, Young Sik Lee
AIM: We compare the efficacy of bupropion and escitalopram treatments in internet gaming disorder (IGD) patients. METHODS: We recruited 119 adolescents and adults with IGD. We treated these participants for 6 weeks in three groups as follows: 44 participants were treated with bupropion SR (bupropion group), 42 participants were treated with escitalopram (escitalopram group), and 33 patients without any medication were observed in the community (observation group)...
August 4, 2016: Psychiatry and Clinical Neurosciences
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