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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/28715136/underweight-and-hypoalbuminemia-as-risk-indicators-for-mortality-among-psychiatric-patients-with-medical-comorbidities
#1
Takahiro Haga, Kae Ito, Masahiro Ono, Jiro Maruyama, Mari Iguchi, Hitoe Suzuki, Eiji Hayashi, Kentaro Sakashita, Tomoko Nagao, Shohei Ikemoto, Asuka Okaniwa, Makiko Kitami, Eriko Inuo, Koichiro Tatsumi
AIM: Medical comorbidities are a major cause of death among patients with mental illness. The purpose of this study was to clarify the risk factors for mortality among psychiatric patients with medical comorbidities. METHODS: We retrospectively reviewed the clinical files of patients transferred to Tokyo Metropolitan Matsuzawa Hospital from a psychiatric hospital to treat medical comorbidities during the three-year period from January 2014 to December 2016. We analyzed the clinical differences between the expired and alive patients...
July 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28692185/an-application-of-functional-near-infrared-spectroscopy-as-supplementary-examination-for-diagnosis-of-clinical-stages-of-psychosis-spectrum
#2
Shinsuke Koike, Satomura Yoshihiro, Shingo Kawasaki, Yukika Nishimura, Akihide Kinoshita, Hanako Sakurada, Mika Yamagishi, Eriko Ichikawa, Jun Matsuoka, Naohiro Okada, Ryu Takizawa, Kiyoto Kasai
AIM: Research efforts aiming at neuroimaging-aided differential diagnosis for psychiatric disorders have been progressing rapidly. A previous multisite study has developed supplementary diagnostic system using functional near-infrared spectroscopy (fNIRS) that can be easily applied to clinical settings. However, few neuroimaging biomarkers have been developed for psychosis spectrum with various clinical stages. METHODS: We employed the fNIRS as a clinical examination device for 143 participants, comprising 47 ultra-high risk (UHR) individuals, 30 patients with first-episode psychosis (FEP), 34 patients with chronic schizophrenia (ChSZ), and 33 healthy controls, who were independent of the previous study...
July 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28675555/rna-sequencing-in-postmortem-human-brains-of-neuropsychiatric-disorders
#3
Chun Wu, Raphael M Bendriem, Susanna P Garamszegi, Lei Song, Chun-Ting Lee
RNA sequencing (RNA-Seq), a revolutionary tool for transcriptome profiling, is becoming increasingly important for neuroscientists in studying the transcriptional landscape of the human brain. Studies using this next generation sequencing (NGS) technique have already revealed novel insights into the complexity of neurons in the human brain and pathogenesis of complex neurological diseases. In clinical neuroscience, RNA-Seq provides exciting opportunities for improving diagnosis and treatment of neurological diseases by facilitating the development of pharmacotherapies able to modulate gene expression...
July 4, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28657695/rare-pdcd11-variations-are-not-associated-with-risk-of-schizophrenia-in-japan
#4
Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Naoshi Kaneko, Tatsuyuki Muratake, Naofumi Shinmyo, Ikuo Otsuka, Shujiro Okuda, Emiko Inoue, Hirofumi Igeta, Masako Shibuya, Jun Egawa, Naoki Orime, Ichiro Sora, Toshiyuki Someya
AIM: Rare gene variations are thought to confer substantial risk for schizophrenia. We performed a three-stage study to identify rare variations that have a strong impact on the risk of developing schizophrenia. METHODS: In the first stage, we prioritized rare missense variations using whole-exome sequencing (WES) data from three families, consisting of a proband, an affected sibling, and parents. In the second stage, we performed targeted resequencing of the PDCD11 coding region in 96 patients...
June 28, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28657683/association-between-social-functioning-and-prefrontal-cortex-function-during-a-verbal-fluency-task-in-schizophrenia-a-near-infrared-spectroscopic-study
#5
Masashi Itakura, Shenghong Pu, Hiroaki Ohdachi, Hiroshi Matsumura, Katsutoshi Yokoyama, Izumi Nagata, Masaaki Iwata, Koichi Kaneko
AIM: Impaired social functioning is a common characteristic of patients with schizophrenia. Social functioning requires the complex operation of various executive functions. Deficits in the prefrontal cortex (PFC) have been implicated in executive dysfunction. Here we aimed to clarify the relationship between subjectively and objectively assessed social functioning, and their associations with PFC function in patients with schizophrenia. METHODS: Twenty-three patients and twenty-two age- and sex-matched healthy controls (HCs) were assessed...
June 28, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28632358/increased-beta-power-in-the-bereaved-families-of-the-sewol-ferry-disaster-a-paradoxical-compensatory-phenomenon-a-two-channel-electroencephalography-study
#6
Kuk-In Jang, Miseon Shim, Sang Min Lee, Hyu Jung Huh, Seung Huh, Ji-Young Joo, Seung-Hwan Lee, Jeong-Ho Chae
AIM: The Sewol ferry capsizing accident in South Korea's southern coast had resulted in the death of 304 people, and serious bereavement problems of their families. Electroencephalography (EEG) beta frequency is associated with psychiatric symptoms such as insomnia. The aim of this study was to investigate the relationship between frontal beta power, psychological symptoms, and insomnia in the bereaved families. METHODS: Eighty-four family members of the Sewol ferry victims (32 men and 52 women) were recruited and their EEG was compared with that of 25 (13 men and 12 women) healthy controls...
June 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28631869/lateralized-hippocampal-volume-increase-following-high-frequency-left-prefrontal-repetitive-transcranial-magnetic-stimulation-in-patients-with-major-depression
#7
Shunsuke Hayasaka, Motoaki Nakamura, Yoshihiro Noda, Takuji Izuno, Takashi Saeki, Hideo Iwanari, Yoshio Hirayasu
AIM: Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for patients with treatment-resistant depression in recent years, and a large body of evidence has demonstrated its therapeutic efficacy through stimulating neuronal plasticity. The aim of this study was to investigate structural alterations in the hippocampus (HIPP) and amygdala (AM) following conventional rTMS in patients with depression. METHODS: Twenty-eight patients with depression underwent 10 daily 20-Hz left prefrontal rTMS over 2 weeks...
June 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28573830/the-psychophysiological-effects-of-oxytocin-on-parent-child-interactions-a-literature-review-oxytocin-and-parent-child-interactions
#8
REVIEW
Monika Szymanska, Marie Schneider, Carmela Chateau-Smith, Sylvie Nezelof, Lauriane Vulliez-Coady
Oxytocin (OT), often called the "hormone of love" or "hormone of attachment", plays a fundamental role in the establishment and quality of parent-infant bonding. However, emerging evidence indicates that OT can also produce antisocial behavior. To clarify these effects, we review studies examining the role of endogenous and exogenous OT on several determinants of attachment: parental sensitivity, and bonding or synchrony in parent-child dyads. Contextual and individual factors moderating the effect of intranasal OT (INOT) and its peripheral levels are also reviewed...
June 2, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28573688/autoantibodies-against-voltage-gated-potassium-channel-vgkc-and-glutamic-acid-decarboxylase-gad-in-psychosis-a-systematic-review-meta-analysis-and-case-series
#9
REVIEW
Rosemary Grain, John Lally, Brendon Stubbs, Steffi Malik, Anne Lemince, Timothy R Nicholson, Robin M Murray, Fiona Gaughran
Antibodies to the voltage-gated potassium channel (VGKC) complex and glutamic acid decarboxylase (GAD) have been reported in some cases of psychosis. We conducted the first systematic review and meta-analysis to investigate their prevalence in people with psychosis and report a case series of VGKC-complex antibodies in refractory psychosis. Only five studies presenting prevalence rates of VGKC seropositivity in psychosis were identified, in addition to our case series, with an overall prevalence of 1.5% (25/1720) compared to 0...
June 2, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28569425/pituitary-gaba-receptor-stimulation-by-carnitine-may-be-a-new-strategy-for-antipsychotic-induced-hyperprolactinemia
#10
LETTER
Masaru Nakamura, Takahiko Nagamine
Hyperprolactinemia is a frequent adverse effect of antipsychotic medication. When antipsychotic-induced hyperprolactinemia warrants treatment, several approaches can be attempted, such as dose reduction of the offending antipsychotic, switch to a prolactin-sparing antipsychotic, addition of aripiprazole to the current regimen, and addition of a dopamine agonist. (1) These strategies sometimes carry the risk of precipitating an exacerbation or relapse of psychotic symptoms.
June 1, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28556440/relationship-between-maternal-depression-and-bonding-failure-a-prospective-cohort-study-of-pregnant-women
#11
Masako Ohara, Takashi Okada, Chika Kubota, Yukako Nakamura, Tomoko Shiino, Branko Aleksic, Mako Morikawa, Aya Yamauchi, Yota Uno, Satomi Murase, Setsuko Goto, Atsuko Kanai, Tomoko Masuda, Masahiko Ando, Norio Ozaki
AIM: Although the association between maternal depression and bonding failure during pregnancy and after delivery has been investigated, the causal relationships remain unclear. METHODS: A total of 751 women (mean [SD] age 32.1 [4.4] years) completed the Mother-Infant Bonding Questionnaire and the Edinburgh Postnatal Depression Scale in early pregnancy before week 25 (T1), in late pregnancy around week 36 (T2), and 5 days after delivery (T3). We created a structural regression model to clarify the relationships between depressive mood and bonding failure during pregnancy and 5 days after delivery...
May 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28547882/re-adjusting-the-cut-off-score-of-the-korean-version-of-the-childhood-autism-rating-scale-for-high-functioning-individuals-with-autism-spectrum-disorder
#12
Hyuk-Jin Kwon, Hee-Jeong Yoo, Joo-Hyun Kim, Dong-Hyun Noh, Hyun-Jung Sunwoo, Ye Seul Jeon, Sang-Youn Lee, Ye-Ul Jo, Gui-Young Bong
AIM: The current cut-off score of the Korean version of the Childhood Autism Rating Scale(K-CARS) does not seem sensitive enough to precisely diagnose high-functioning autism. The aim of this study was to identify the optimal cut-off score of K-CARS for diagnosing high-functioning individuals with Autism Spectrum Disorders(ASD). METHODS: A total of 329 participants were assessed by the Korean versions of the Autism Diagnostic Interview - Revised (K-ADI-R), Autism Diagnostic Observation Schedule (K-ADOS), and K-CARS...
May 26, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28523821/risk-factors-for-early-cardiovascular-mortality-in-patients-with-bipolar-disorder
#13
Shang-Ying Tsai, Chao-Hsien Lee, Pao-Huan Chen, Kuo-Hsuan Chung, Shou-Hung Huang, Chian-Jue Kuo, Wen-Cheng Wu
AIM: We attempted to determine risk factors, particularly pathophysiological changes, for the early cardiovascular mortality in bipolar disorder. METHODS: A total of 5416 in-patients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD, ICD 9: 401-443) before the age of 65 years were identified. Two living bipolar patients and two mentally healthy adults were matched with each one deceased patient as control subjects according to age (±2 years), sex, and date (±3 years) of the final/index admission or the date of general health screening...
May 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28523718/does-sleep-disturbance-affect-the-amyloid-clearance-mechanisms-in-alzheimer-s-disease
#14
REVIEW
Burak Yulug, Lutfu Hanoglu, Ertugrul Kilic
Sleep is one of the important factors that play a key role in AD pathogenesis. However, it is still unclear whether poor quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in amyloid beta (Aβ) clearance metabolism. To that end, we discussed possible mechanisms underlying the bidirectional interaction between the sleep deprivation and amyloid beta (Aβ) clearance pathways...
May 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28459504/verbal-memory-impairments-in-bipolar-disorder-effect-of-type-of-word-learning-tasks
#15
LETTER
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
No abstract text is available yet for this article.
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28459134/differences-in-neural-responses-to-reward-and-punishment-processing-between-anorexia-nervosa-subtypes-an-fmri-study
#16
Ema Murao, Genichi Sugihara, Masanori Isobe, Tomomi Noda, Michiko Kawabata, Noriko Matsukawa, Hidehiko Takahashi, Toshiya Murai, Shun'ichi Noma
AIM: Anorexia nervosa (AN) includes the restricting (AN-r) and binge-eating/purging (AN-bp) subtypes, which have been reported to differ regarding their underlying pathophysiologies as well as their behavioral patterns. However, the differences in neural mechanisms of reward systems between AN subtypes remain unclear. The aim of the present study was to explore differences in the neural processing of reward and punishment between AN subtypes. METHODS: Twenty-three female patients with AN (11 AN-r and 12 AN-bp) and 20 healthy women underwent functional magnetic resonance imaging while performing a monetary incentive delay task...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28457018/modulation-of-the-n400-component-in-relation-to-hypomanic-personality-traits-in-a-word-meaning-ambiguity-resolution-task
#17
Delphine Raucher-Chéné, Sarah Terrien, Pamela Gobin, Fabien Gierski, Arthur Kaladjian, Chrystel Besche-Richard
AIM: High levels of hypomanic personality traits have been associated with an increased risk of developing bipolar disorder (BD). Changes in semantic content, impaired verbal associations, abnormal prosody, and abnormal speed of language are core features of BD, and are thought to be related to semantic processing abnormalities. In the present study, we used event-related potentials to investigate the relation between semantic processing (N400 component) and hypomanic personality traits...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28457001/plasma-copeptin-and-metabolic-dysfunction-in-individuals-with-bipolar-disorder
#18
Rodrigo B Mansur, Lucas B Rizzo, Camila M Santos, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
AIM: This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relationship between copeptin and metabolic parameters. METHODS: We measured plasma levels of copeptin in individuals with BD (N = 55) and healthy controls (N = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28670828/retraction-statement-long-term-efficacy-and-safety-of-blonanserin-in-patients-with-first-episode-schizophrenia-a-1-year-open-label-trial-by-y-ninomiya-s-miyamoto-t-tenjin-s-ogino-n-miyake-y-kaneda-t-sumiyoshi-and-n-yamaguchi
#19
https://www.readbyqxmd.com/read/28670827/toward-the-inclusion-of-gaming-disorder-in-icd-11
#20
EDITORIAL
Susumu Higuchi
No abstract text is available yet for this article.
July 2017: Psychiatry and Clinical Neurosciences
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