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Psychiatry and Clinical Neurosciences

Yuan-Pin Hung, Carol Sheei-Meei Wang, Chia-Nan Yen, Hsun-Cheng Chang, Po See Chen, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Ru-Band Lu, Tzu-Yun Wang
AIM: Clozapine-associated fever is common but the specific cytokine changes and treatment durations that may cause fever remain unknown. We investigate the association between inflammatory cytokine changes and clozapine-induced fever in patients who were treated with clozapine. METHODS: Forty-three patients with schizophrenia or schizoaffective disorder, diagnosed by using the Chinese Version of the Mini International Neuropsychiatric Interview, were treated with clozapine for the first time (first-time use group, n = 22) or more than 6 months (long-term use group, n = 21)...
January 20, 2017: Psychiatry and Clinical Neurosciences
Naruhisa Yamaki, Akitoyo Hishimoto, Ikuo Otsuka PhD, Toru Sasada, Shuken Boku, Takeo Saito, Yuka Yasuda, Hidenaga Yamamori, Masashi Ikeda, Manabu Ikeda, Ichiro Sora, Nakao Iwata, Ryota Hashimoto
In Japan, there have been few cases of clozapine rechallenge following clozapine-induced granulocytopenia. We report our experience with a case of the successful rechallenge with clozapuine, and we confirmed that the patient had a low risk of clozapine-induced granulocytopenia using human leukocyte antigen typing. We hope clinicians more often consider clozapine rechallenge with a risk assessment including human leukocyte antigen typing in Japan. To our knowledge, this is the first case report giving a hopeful way to screen for clozapine-induced granulocytopenia in clozapine rechallenge...
January 18, 2017: Psychiatry and Clinical Neurosciences
Yuan Feng, Yuan-Yuan Wang, Wei Huang, Gabor S Ungvari, Chee H Ng, Gang Wang, Zhen Yuan, Yu-Tao Xiang
AIM: Bipolar disorder (BD) is frequently misdiagnosed as major depression and hence reliable and culturally appropriate screening tools are needed. This study compared the 32-item Hypomania Checklist (HCL-32), the 33-item Hypomania Checklist (HCL-33), and the Mood Disorders Questionnaire (MDQ) for BD. METHODS: Altogether, 350 depressed patients were included. The HCL-32, the HCL-33 and the MDQ were completed by patients to identify manic and/or hypomanic symptoms...
January 17, 2017: Psychiatry and Clinical Neurosciences
Megumi Fujieda, Katsuhisa Uchida, Shinichiro Ikebe, Akihiro Kimura, Masashi Kimura, Toshiaki Watanabe, Hisako Sakamoto, Teruaki Matsumoto, Naohisa Uchimura
AIM: Depression is often undiagnosed in primary care. Asking about sleep status is much easier than asking about mood. This study was conducted to examine the relation between insomnia and depression. METHODS: New patients aged 35-64 years were recruited from internal medicine clinics in Japan. Self-administered questionnaires were employed. Depression was evaluated by the Zung Self-Rating Depression Scale and the Profile of Mood States. Sleep status was investigated using the Pittsburgh Sleep Quality Index...
January 17, 2017: Psychiatry and Clinical Neurosciences
Masayuki Inoue, Yoshihisa Shoji, Takefumi Ueno, Kiichiro Morita, Toshi Abe, Naohisa Uchimura
No abstract text is available yet for this article.
December 30, 2016: Psychiatry and Clinical Neurosciences
Noriaki Yahata, Kiyoto Kasai, Mitsuo Kawato
Psychiatry research has long experienced a stagnation stemming from a lack of understanding of the neurobiological underpinnings of phenomenologically defined mental disorders. Recently, the application of computational neuroscience to psychiatry research has shown great promise in establishing a link between phenomenological and pathophysiological aspects of mental disorders, thereby recasting current nosology in more biologically meaningful dimensions. In this review, we highlight recent investigations in computational neuroscience that undertook either theory- or data-driven approaches to quantitatively delineate the mechanisms of mental disorders...
December 29, 2016: Psychiatry and Clinical Neurosciences
Hidenobu Suzuki, Hiroyuki Hibino, Yuichi Inoue, Katsunaka Mikami
No abstract text is available yet for this article.
December 27, 2016: Psychiatry and Clinical Neurosciences
Nozomi Ishisaka, Satomi Shimano, Tomofumi Miura, Keisuke Motomura, Machiko Horii, Hisako Imanaga, Junji Kishimoto, Yasuhiro Kaneda, Ichiro Sora, Shigenobu Kanba
AIM: Neurocognitive impairment is one of the core symptoms of bipolar disorder. The MATRICS Cognitive Consensus Battery (MCCB) is a potential consensus assessment tool to evaluate cognitive function in patients with bipolar disorder. Here, we report on cognitive deficits evaluated using the MCCB Japanese version (MCCB-J) in euthymic Japanese patients with bipolar disorder, and compare them with scores in previous studies. METHODS: We compared neurocognitive function in 25 patients with euthymic bipolar disorder and 53 healthy controls...
December 27, 2016: Psychiatry and Clinical Neurosciences
Devrimsel Harika Ertem, Ayten Ceyhan Dirican, Agah Aydın, Sevim Baybas, Vedat Sözmen, Musa Ozturk, Yavuz Altunkaynak
AIM: The relation of epilepsy with psychiatric disorders is of great interest to researchers due to its behavioral, social and cognitive outcomes. In this study, we explored psychiatric comorbidity and its effects on quality of life in patients with mesial temporal lobe epilepsy (MTLE) and juvenile myoclonic epilepsy (JME). METHOD: Thirthy patients with MTLE, 30 patients with JME and 30 healthy controls were administered structured clinical interview for DSM-IV (SCID-I) to diagnose psychiatric disorders...
December 27, 2016: Psychiatry and Clinical Neurosciences
Sara Poletti, Veronica Aggio, Silvia Brioschi, Sara Dallaspezia, Cristina Colombo, Francesco Benedetti
AIM: Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in depression. These deficits are observable both in major depression (MDD) and in bipolar disorder (BD) and are present in each phase of the disorders, including euthymia. Adverse childhood experiences (ACE) have been associated to an increased risk to develop psychiatric disorders and cognitive deficits. The aim of the study was to assess neuropsychological performances in a sample of MDD and BD patients during a depressive episode compared to healthy controls and secondly to investigate if ACE affect the cognitive profile in the three groups...
December 22, 2016: Psychiatry and Clinical Neurosciences
Manami Kodaka, Toshihiko Matsumoto, Takashi Yamauchi, Michiko Takai, Norihito Shirakawa, Tadashi Takeshima
AIM: Although the female suicide rate in Japan is one of the highest among OECD countries, little has been done to assess the psychosocial and psychiatric characteristics of Japanese female suicide completers. This study aimed to examine gender differences in psychosocial and psychiatric characteristics of suicide completers using a psychological autopsy study method, and identify female suicide factors and intervention points to prevent female suicides. METHODS: A semi-structured interview was conducted with close family members of adult suicide completers...
December 22, 2016: Psychiatry and Clinical Neurosciences
Hideki Nakayama, Satoko Mihara, Susumu Higuchi
Recently many young people have developed internet use disorders (IUDs) as a result of the proliferation of internet enabled devices, leading to serious health and social problems worldwide. On occasion, medical and educational institutions, governments and other groups, have sought to take preventive action or treat IUDs. In many cases, the preferred treatment for IUDs is to set recommendations for appropriate internet use. Reportedly, psychosocial therapies (including CBT, family therapy, compound therapy) for IUDs and pharmacotherapies (including antidepressant drugs and psychostimulants) for co-morbid psychiatric or development disorders have been effective at reducing the degree and symptoms of IUDs...
December 17, 2016: Psychiatry and Clinical Neurosciences
Eiji Kirino, Shoji Tanaka, Mayuko Fukuta, Rie Inami, Heii Arai, Reiichi Inoue, Shigeki Aoki
AIMS: It remains unclear how functional connectivity (FC) may be related to specific cognitive domains in neuropsychiatric disorders. Here we used simultaneous resting-state functional MRI (rsfMRI) and electroencephalography (EEG) recording in patients with schizophrenia, to evaluate FC within and outside the default mode network (DMN). METHODS: Our study population included 14 patients with schizophrenia and 15 healthy control participants. From all participants, we acquired rsfMRI data, and simultaneously recorded EEG data using an MR-compatible amplifier...
December 17, 2016: Psychiatry and Clinical Neurosciences
Toshikazu Shinba
AIM: The aim of the present study was to examine whether depression and anxiety disorder manifest different autonomic dysregulations using heart rate variability (HRV) and heart rate (HR) measurements. METHODS: HRV and HR were recorded both at rest and during task execution (random number generation) in the first-onset drug-naïve patients with major depressive disorder (MDD, n = 14) and generalized anxiety disorder (GAD, n = 11) as well as in healthy controls (n = 41)...
December 17, 2016: Psychiatry and Clinical Neurosciences
Takaoki Kasahara, Mizuho Ishiwata, Chihiro Kakiuchi, Satoshi Fuke, Nakao Iwata, Norio Ozaki, Hiroshi Kunugi, Yoshio Minabe, Kazuhiko Nakamura, Yasuhide Iwata, Kumiko Fujii, Shigenobu Kanba, Hiroshi Ujike, Ichiro Kusumi, Muneko Kataoka, Nana Matoba, Atsushi Takata, Kazuya Iwamoto, Takeo Yoshikawa, Tadafumi Kato
AIMS: Rare missense variants, which likely account for a substantial portion of the genetic 'dark matter' for a common complex disease, are challenging because the impact of variants on disease development are difficult to substantiate. This study aimed to examine the impacts of amino acid substitution variants in the POLG1 found in bipolar disorder, as an example and proof of concept, in three different modalities of assessment: in-silico predictions, in-vitro biochemical assays, and clinical evaluation...
December 17, 2016: Psychiatry and Clinical Neurosciences
Taichi Mogi, Hiroyuki Toda, Yasutaka Tatsuzawa, Tsubasa Fukutomi, Shigeyoshi Soga, Hiroshi Shinmoto, Aihide Yoshino
No abstract text is available yet for this article.
December 15, 2016: Psychiatry and Clinical Neurosciences
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Hiroko Kubo, Yukio Tada, Yukiko Tomioka, Shinya Watanabe, Masatoshi Inoshita, Makoto Kinoshita, Masashi Ohta, Tetsuro Ohmori
AIMS: The purpose of this study was to elucidate determinants of quality of life (QOL) in anorexia nervosa (AN) patients. METHODS: Twenty-one female patients with AN participated in the study. QOL was assessed with the 36-Item Short Form Health Survey (SF-36), and cognitive function was evaluated using the Wisconsin Card Sorting Test Keio version (KWCST), the Rey Complex Figure Test (RCFT) and the Social Cognition Screening Questionnaire. Clinical symptoms were evaluated with the Beck Depression Inventory-II (BDI- II), the State-Trait Anxiety Inventory-Form JYZ (STAI-JYZ) and the Maudsley Obsessive Compulsive Inventory...
December 14, 2016: Psychiatry and Clinical Neurosciences
Kunihiko Takahashi, Hisateru Tachimori, Chiemi Kan, Daisuke Nishi, Yasuyuki Okumura, Naohiro Kato, Tadashi Takeshima
AIM: The aim of our study was to clarify the geographical movement of patients treated in psychiatric facilities, which can provide important information on the resources and health-care system of psychiatric services. METHODS: We conducted an analysis of nationwide data on psychiatric patients, collected as an additional survey to the conventional '630 survey' in 2014. For the 151 848 initially admitted inpatients during 6 months and the 144 401 outpatients on a specific day, we identified whether a patient was admitted to a psychiatric facility located in the same medical area as his/her residence...
December 13, 2016: Psychiatry and Clinical Neurosciences
Xudong Li, Shuang Xue, Shuhong Jia, Zhi Zhou, Yanan Qiao, Chunlei Hou, Kun Wei, Wenjing Zheng, Pei Rong, Jinsong Jiao
AIMS: We investigated preclinical abnormalities revealed by transcranial sonography (TCS) in patients with idiopathic REM sleep behavior disorder (iRBD) compared with those revealed in patients with multiple system atrophy (MSA) or Parkinson's disease (PD) and in normal controls. METHODS: Twenty-two patients with iRBD, 21 patients with MSA, 22 patients with PD and 21 normal controls were included in this study. All participants underwent one night of video-polysomnography (PSG) monitoring, and the sleep parameters were analyzed using Polysmith software and by visual analysis...
November 29, 2016: Psychiatry and Clinical Neurosciences
Junko Matsumoto, Yoshiyuki Hirano, Kenji Hashimoto, Tamaki Ishima, Nobuhisa Kanahara, Tomihisa Niitsu, Akihiro Shiina, Tasuku Hashimoto, Yasunori Sato, Koutaro Yokote, Shunichi Murano, Hiroshi Kimura, Yutaka Hosoda, Eiji Shimizu, Masaomi Iyo, Michiko Nakazato
AIMS: The aims of this study were to determine whether the serum levels of precursor brain-derived neurotrophic factor (proBDNF), mature BDNF (mBDNF), and matrix metalloproteinase-9 (MMP-9) are altered in patients with eating disorders (EDs) including anorexia nervosa (AN) and bulimia nervosa (BN), and to explore whether those levels are associated with decision-making abilities. METHODS: Nineteen women with AN, 28 women with BN, and 22 age-matched healthy women (HC) were enrolled in the current study...
November 28, 2016: Psychiatry and Clinical Neurosciences
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