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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/28233379/optogenetics-applications-in-psychiatric-research
#1
Fukutoshi Shirai, Akiko Hayashi-Takagi
Recently, optogenetic techniques emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics result from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond time scale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine-tuning cannot be achieved using traditional methods...
February 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28220654/longitudinal-study-examining-abnormal-white-matter-integrity-using-a-tract-specific-analysis-in-individuals-with-a-high-risk-for-psychosis
#2
Junichi Saito, Masaaki Hori, Takahiro Nemoto, Naoyuki Katagiri, Keigo Shimoji, Shinya Ito, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
AIM: Although volume reductions in the grey matter have been previously observed in individuals with an at-risk mental state (ARMS) for psychosis, the features of white matter integrity and their correlation with psychiatric symptoms remain unclear. METHODS: Forty-six ARMS subjects were examined using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images; the subjects were also evaluated using the Scale of Prodromal Symptoms at baseline and at 52 weeks...
February 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28211213/response-to-enrichment-of-deleterious-variants-of-mitochondrial-dna-polymerase-gene-polg1-in-bipolar-disorder
#3
LETTER
Tadafumi Kato, Takaoki Kasahara
No abstract text is available yet for this article.
February 16, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28191687/clinical-pharmacokinetic-interactions-between-lamotrigine-and-hormonal-contraceptives-in-bipolar-i-disorder
#4
LETTER
Ryo Sawagashira, Yutaka Fujii, Ichiro Kusumi
Lamotrigine (LTG) is prescribed for bipolar disorder and epilepsy. Oral contraceptives (OCs) containing estrogen may reciprocally decrease the concentration of LTG. We present a case of a female patient with bipolar I disorder with prolonged time to remission due to difficulty maintaining optimal serum concentrations of LTG.
February 13, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28182301/factor-analyzing-the-norwegian-matrics-consensus-cognitive-battery
#5
Christine Mohn, June Ullevoldsaeter Lystad, Torill Ueland, Erik Falkum, Bjørn Rishovd Rund
AIM: The MATRICS Consensus Cognitive Battery (MCCB) assesses seven cognitive domains with ten subtests. This domain structure has not been demonstrated. Three factors have been produced in US samples. We examined the dimensional structure of the Norwegian MCCB. In addition, we studied the contribution of each subtest to the battery sum score. METHODS: The participants were 131 patients with schizophrenia spectrum disorders and 300 healthy controls. Their Norwegian MCCB test scores were subject to exploratory and confirmatory factor analysis and regression analysis...
February 9, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28177184/associations-between-renaming-schizophrenia-and-stigma-related-outcomes-a-systematic-review
#6
Sosei Yamaguchi, Masashi Mizuno, Yasutaka Ojio, Utako Sawada, Asami Matsunaga, Shuntaro Ando, Shinsuke Koike
Renaming schizophrenia is a potential strategy to reduce the stigma attached to people with schizophrenia. However, the overall associations between renaming schizophrenia and stigma-related outcomes have not been fully elucidated. We conducted a systematic review of studies that empirically examined the outcomes between new or alternative terms and old or existing terms for schizophrenia. We searched for relevant articles in eight bibliographic databases, conducted a Google search, examined reference lists, and contacted relevant experts...
February 8, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28177178/association-of-premorbid-personality-with-behavioral-and-psychological-symptoms-in-dementia-with-lewy-bodies-comparison-with-alzheimer-s-disease-patients
#7
Kazuki Tabata, Yasuaki Saijo, Fumiyoshi Morikawa, Juichiro Naoe, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Takahiko Yoshida
AIM: The aim of this study was to elucidate the relationship between premorbid personality traits and behavioral and psychological symptoms in dementia (BPSD) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients. METHODS: Forty-one DLB patients and 98 AD patients were assessed for BPSD using the Neuropsychiatric Inventory (NPI). Each patient's midlife personality traits were rated by a family member using the NEO Five-Factor Inventory (NEO-FFI) questionnaire...
February 8, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28106314/role-of-cytokine-changes-in-clozapine-induced-fever-a-cohort-prospective-study
#8
Yuan-Pin Hung, Carol Sheei-Meei Wang, Chia-Nan Yen, Hsun-Cheng Chang, Po See Chen, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Ru-Band Lu, Tzu-Yun Wang
AIM: Clozapine-associated fever is common but the specific cytokine changes and treatment durations that may cause fever remain unknown. We investigate the association between inflammatory cytokine changes and clozapine-induced fever in patients who were treated with clozapine. METHODS: Forty-three patients with schizophrenia or schizoaffective disorder, diagnosed by using the Chinese Version of the Mini International Neuropsychiatric Interview, were treated with clozapine for the first time (first-time use group, n = 22) or more than 6 months (long-term use group, n = 21)...
January 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28097743/optimizing-outcomes-in-clozapine-rechallenge-following-neutropenia-using-human-leukocyte-antigen-typing-a-case-report
#9
LETTER
Naruhisa Yamaki, Akitoyo Hishimoto, Otsuka Ikuo, Toru Sasada, Shuken Boku, Takeo Saito, Yuka Yasuda, Hidenaga Yamamori, Masashi Ikeda, Manabu Ikeda, Ichiro Sora, Nakao Iwata, Ryota Hashimoto
In Japan, there have been few cases of clozapine rechallenge following clozapine-induced granulocytopenia. We report our experience with a case of the successful rechallenge with clozapuine, and we confirmed that the patient had a low risk of clozapine-induced granulocytopenia using human leukocyte antigen typing. We hope clinicians more often consider clozapine rechallenge with a risk assessment including human leukocyte antigen typing in Japan. To our knowledge, this is the first case report giving a hopeful way to screen for clozapine-induced granulocytopenia in clozapine rechallenge...
January 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28094461/comparison-of-the-32-item-hypomania-checklist-hcl-32-the-33-item-hypomania-checklist-hcl-33-and-the-mood-disorders-questionnaire-mdq-for-bipolar-disorder
#10
Yuan Feng, Yuan-Yuan Wang, Wei Huang, Gabor S Ungvari, Chee H Ng, Gang Wang, Zhen Yuan, Yu-Tao Xiang
AIM: Bipolar disorder (BD) is frequently misdiagnosed as major depression and hence reliable and culturally appropriate screening tools are needed. This study compared the 32-item Hypomania Checklist (HCL-32), the 33-item Hypomania Checklist (HCL-33), and the Mood Disorders Questionnaire (MDQ) for BD. METHODS: Altogether, 350 depressed patients were included. The HCL-32, the HCL-33 and the MDQ were completed by patients to identify manic and/or hypomanic symptoms...
January 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28094458/inquiring-about-insomnia-may-facilitate-diagnosis-of-depression-in-the-primary-care-setting
#11
Megumi Fujieda, Katsuhisa Uchida, Shinichiro Ikebe, Akihiro Kimura, Masashi Kimura, Toshiaki Watanabe, Hisako Sakamoto, Teruaki Matsumoto, Naohisa Uchimura
AIM: Depression is often undiagnosed in primary care. Asking about sleep status is much easier than asking about mood. This study was conducted to examine the relation between insomnia and depression. METHODS: New patients aged 35-64 years were recruited from internal medicine clinics in Japan. Self-administered questionnaires were employed. Depression was evaluated by the Zung Self-Rating Depression Scale and the Profile of Mood States. Sleep status was investigated using the Pittsburgh Sleep Quality Index...
January 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28039921/right-hemispheric-hyperfrontality-in-schizophrenia-during-a-shiritori-task-an-fmri-study
#12
LETTER
Masayuki Inoue, Yoshihisa Shoji, Takefumi Ueno, Kiichiro Morita, Toshi Abe, Naohisa Uchimura
No abstract text is available yet for this article.
December 30, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28032396/computational-neuroscience-approach-to-biomarkers-and-treatments-for-mental-disorders
#13
Noriaki Yahata, Kiyoto Kasai, Mitsuo Kawato
Psychiatry research has long experienced a stagnation stemming from a lack of understanding of the neurobiological underpinnings of phenomenologically defined mental disorders. Recently, the application of computational neuroscience to psychiatry research has shown great promise in establishing a link between phenomenological and pathophysiological aspects of mental disorders, thereby recasting current nosology in more biologically meaningful dimensions. In this review, we highlight recent investigations in computational neuroscience that undertook either theory- or data-driven approaches to quantitatively delineate the mechanisms of mental disorders...
December 29, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28025875/benefit-of-extending-the-dosing-interval-of-long-acting-antipsychotic-injections-on-schizophrenics-with-extrapyramidal-symptoms
#14
LETTER
Hidenobu Suzuki, Hiroyuki Hibino, Yuichi Inoue, Katsunaka Mikami
No abstract text is available yet for this article.
December 27, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28025861/neurocognitive-profile-of-euthymic-japanese-patients-with-bipolar-disorder
#15
Nozomi Ishisaka, Satomi Shimano, Tomofumi Miura, Keisuke Motomura, Machiko Horii, Hisako Imanaga, Junji Kishimoto, Yasuhiro Kaneda, Ichiro Sora, Shigenobu Kanba
AIM: Neurocognitive impairment is one of the core symptoms of bipolar disorder. The MATRICS Cognitive Consensus Battery (MCCB) is a potential consensus assessment tool to evaluate cognitive function in patients with bipolar disorder. Here, we report on cognitive deficits evaluated using the MCCB Japanese version (MCCB-J) in euthymic Japanese patients with bipolar disorder, and compare them with scores in previous studies. METHODS: We compared neurocognitive function in 25 patients with euthymic bipolar disorder and 53 healthy controls...
December 27, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28025856/exploring-psychiatric-comorbidities-and-their-effects-on-quality-of-life-in-patients-with-temporal-lobe-epilepsy-and-juvenile-myoclonic-epilepsy
#16
Devrimsel Harika Ertem, Ayten Ceyhan Dirican, Agah Aydın, Sevim Baybas, Vedat Sözmen, Musa Ozturk, Yavuz Altunkaynak
AIM: The relation of epilepsy with psychiatric disorders is of great interest to researchers due to its behavioral, social and cognitive outcomes. In this study, we explored psychiatric comorbidity and its effects on quality of life in patients with mesial temporal lobe epilepsy (MTLE) and juvenile myoclonic epilepsy (JME). METHOD: Thirthy patients with MTLE, 30 patients with JME and 30 healthy controls were administered structured clinical interview for DSM-IV (SCID-I) to diagnose psychiatric disorders...
December 27, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28004481/multidimensional-cognitive-impairment-in-unipolar-and-bipolar-depression-and-the-moderator-effect-of-adverse-childhood-experiences
#17
Sara Poletti, Veronica Aggio, Silvia Brioschi, Sara Dallaspezia, Cristina Colombo, Francesco Benedetti
AIM: Studies have demonstrated neuropsychological deficits across a variety of cognitive domains in depression. These deficits are observable both in major depressive disorder (MDD) and in bipolar disorder (BD) and are present in each phase of the illness, including euthymia. Adverse childhood experiences (ACE) have been associated with an increased risk of developing psychiatric disorders and cognitive deficits. The aim of this study was to assess neuropsychological performances in a sample of MDD and BD patients during a depressive episode compared to healthy controls (HC) and, to investigate if ACE affect the cognitive profiles in the three groups...
December 22, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28004479/female-suicides-psychosocial-and-psychiatric-characteristics-identified-by-a-psychological-autopsy-study-in-japan
#18
Manami Kodaka, Toshihiko Matsumoto, Takashi Yamauchi, Michiko Takai, Norihito Shirakawa, Tadashi Takeshima
AIM: Although the female suicide rate in Japan is one of the highest among OECD countries, little has been done to assess the psychosocial and psychiatric characteristics of Japanese female suicide completers. This study aimed to examine sex differences in psychosocial and psychiatric characteristics of suicide completers using a psychological autopsy study method, and to identify female suicide factors and intervention points to prevent female suicides. METHODS: A semi-structured interview was conducted with close family members of adult suicide completers...
December 22, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27987253/treatment-and-risk-factors-of-internet-use-disorders
#19
REVIEW
Hideki Nakayama, Satoko Mihara, Susumu Higuchi
Recently many young people have developed internet use disorders (IUDs) as a result of the proliferation of internet enabled devices, leading to serious health and social problems worldwide. On occasion, medical and educational institutions, governments and other groups, have sought to take preventive action or treat IUDs. In many cases, the preferred treatment for IUDs is to set recommendations for appropriate internet use. Reportedly, psychosocial therapies (including CBT, family therapy, compound therapy) for IUDs and pharmacotherapies (including antidepressant drugs and psychostimulants) for co-morbid psychiatric or development disorders have been effective at reducing the degree and symptoms of IUDs...
December 17, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27987251/simultaneous-rsfmri-and-eeg-recordings-of-functional-connectivity-in-patients-with-schizophrenia
#20
Eiji Kirino, Shoji Tanaka, Mayuko Fukuta, Rie Inami, Heii Arai, Reiichi Inoue, Shigeki Aoki
AIMS: It remains unclear how functional connectivity (FC) may be related to specific cognitive domains in neuropsychiatric disorders. Here we used simultaneous resting-state functional MRI (rsfMRI) and electroencephalography (EEG) recording in patients with schizophrenia, to evaluate FC within and outside the default mode network (DMN). METHODS: Our study population included 14 patients with schizophrenia and 15 healthy control participants. From all participants, we acquired rsfMRI data, and simultaneously recorded EEG data using an MR-compatible amplifier...
December 17, 2016: Psychiatry and Clinical Neurosciences
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