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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/30393945/a-comparison-of-cognitive-performance-in-bipolar-disorder-major-depressive-disorder-unaffected-first-degree-relatives-and-healthy-controls
#1
Qijing Bo, Fang Dong, Xianbin Li, Feng Li, Peng Li, Haiting Yu, Fan He, Guofu Zhang, Zhimin Wang, Xin Ma, Chuanyue Wang
AIM: The extent and specifics regarding cognitive dysfunction in patients with bipolar disorder (BD) or major depressive disorder (MDD) and their unaffected first-degree relatives (FDRs) has not been addressed in any single study. The present study compared the cognitive function of patients with BD or MDD, their FDRs, and healthy control (HC) individuals. METHOD: The study population comprised adults (aged 18-55 y) with BD; adults with MDD; FDRs (children or siblings of patients with BD or MDD); and HCs (n = 109, 105, 85, and 95, respectively)...
November 4, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30379387/online-cathodal-transcranial-direct-current-stimulation-to-the-right-homologue-of-broca-s-area-improves-speech-fluency-in-people-who-stutter
#2
Yasuto Yada, Shuta Tomisato, Ryu-Ichiro Hashimoto
AIM: Previous functional imaging studies demonstrate that people who stutter (PWS) exhibit over- and under-activation of Broca's and Wernicke's areas and their right hemisphere homologues when speaking. However, it is unclear whether this altered activation represents the neural cause of speech dysfluency or a secondary compensatory activation in PWS. To clarify the functional significance of the altered activation pattern in classic language areas and their right homologues, we examined whether the severity of stuttering was affected when the activation of these areas was modulated by brain stimulation...
October 31, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30375100/plasma-levels-of-il-1ra-is-associated-with-schizophrenia
#3
Yi Zhou, Wu Peng, Jun Wang, WenJing Zhou, YanHong Zhou, BinWu Ying
AIM: Although peripheral low-grade inflammation and brain-derived neurotrophic factor (BDNF) levels have been implicated in schizophrenia, the interactions between them remains to be fully revealed. We aimed to compare BDNF and cytokines in patients with schizophrenia and healthy controls. Additionally, we aim to investigate the association between peripheral levels of cytokines and BDNF in patients with schizophrenia. METHODS: Plasma levels of BDNF, interferon-γ (IFN-γ), interleukin-10 (IL-10), IL-12, IL-1, IL-6, IL-8, tumor necrosis factor-α (TNF-α), macrophage migration inhibitory (MIF), IL-1 receptor antagonist (IL-1Ra) and CD40 Ligand (CD40 L) were compared in 45 schizophrenia patients and 38 healthy controls by Luminex technology...
October 30, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30375126/cefepime-induced-encephalopathy-cie-neural-mass-modeling-of-triphasic-wave-like-generalized-periodic-discharges-with-a-high-negative-component-tri-hnc
#4
Hidetaka Tamune, Yu Hamamoto, Naofumi Aso, Naoki Yamamoto
AIM: Cefepime, a fourth-generation cephalosporin, acts as a GABAA receptor antagonist. Cefepime-induced encephalopathy (CIE) is frequently overlooked. We aimed to clarify the clinical features, characteristic EEGs, and mechanisms of CIE to aid in its early recognition. METHODS: CIE cases documented by a single-center consultation-liaison team between April 2015 and March 2017 were retrospectively reviewed. For further investigation, neural mass modeling was performed in silico...
October 29, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30375096/problematic-internet-use-and-its-associations-with-health-related-symptoms-and-lifestyle-habits-among-rural-japanese-adolescents
#5
Reiji Kojima, Miri Sato, Yuka Akiyama, Ryoji Shinohara, Sonoko Mizorogi, Kohta Suzuki, Hiroshi Yokomichi, Zentaro Yamagata
AIM: There have been concerns about the increase in problematic Internet use (PIU) and its impact on lifestyle habits and health-related symptoms, given the rapid spread of smartphones. This study aimed to clarify PIU prevalence over 3 years in the same area and investigate lifestyle and health-related factors related to PIU among junior high-school students in Japan. METHODS: Each year during 2014-2016, a survey was conducted with junior high-school students from a rural area of Japan (2014, n = 979; 2015, n = 968; 2016, n = 940)...
October 29, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30375086/adverse-reaction-reports-of-neuroleptic-malignant-syndrome-induced-by-atypical-antipsychotic-agents-in-the-japanese-adverse-drug-event-report-jader-database
#6
Tatsuhiko Anzai, Kunihiko Takahashi, Michiko Watanabe
AIM: This study evaluates reports on neuroleptic malignant syndrome (NMS) as an adverse event associated with the use of atypical antipsychotic agents (AAAs) in Japan. We examined NMS occurrence following monotherapy and combination therapy with AAAs in real clinical practice using the Japanese Adverse Drug Event Report database. METHODS: Adverse drug reaction reports associated with the use of one or more AAAs or haloperidol were analyzed. The odds ratios of NMS occurrence after monotherapy and combination therapy with AAAs without typical antipsychotic agents (TAAs) relative to those after haloperidol monotherapy were estimated using multiple logistic regression...
October 29, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30370626/introducing-ips-supported-employment-in-japan
#7
REVIEW
Robert E Drake, Deborah R Becker, Gary R Bond
Individual Placement and Support (IPS) is a standardized approach to supported employment for people with serious mental disorders, such as schizophrenia and bipolar disorder (1). Because IPS supported employment is relatively new in Japan, mental health and vocational leaders in Japan may not be familiar with the model, the related research, and the International IPS Learning Community. This article provides a brief introduction. This article is protected by copyright. All rights reserved.
October 29, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30367527/exome-sequencing-in-families-with-severe-mental-illness-identifies-novel-and-rare-variants-in-genes-implicated-in-mendelian-neuropsychiatric-syndromes
#8
Suhas Ganesh, Husayn Ahmed P, Ravi Kumar Nadella, Ravi Prabhakar More, Manasa Sheshadri, Biju Viswanath, Mahendra Rao, Sanjeev Jain, Odity Mukherjee
AIM: Severe Mental Illnesses, such as bipolar disorder and schizophrenia, are highly heritable, and have a complex pattern of inheritance. Genome wide association studies detect a part of the heritability, which can be attributed to common genetic variation. Examination of rare variants with Next Generation Sequencing may add to the understanding of genetic architecture of SMIs. METHODS: We analyzed 32 ill subjects from 8 multiplex families; and 33 healthy individuals by whole exome sequencing...
October 27, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30367530/tramadol-associated-pica-a-case-report
#9
LETTER
Nishtha Chawla, Piyali Mandal, Biswadip Chatterjee, Anju Dhawan
Pica has been defined as consumption of non-nutritive substances in a manner which is not sanctioned culturally.1 Pica has often been associated with micronutrient deficiency, but the strength of relationship remains unclear.2 Case reports/series have been published on pica associated with various psychotropic medications, like risperidone, olanzapine.1,3 This article is protected by copyright. All rights reserved.
October 26, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30324673/psychological-distress-among-people-in-fukushima-prefecture-before-and-after-the-great-east-japan-earthquake-using-a-nation-wide-survey
#10
LETTER
Daisuke Nishi, Ryoko Susukida, Kentaro Usuda, Yoshio Yamanouchi
While many studies examined post-disaster mental health after the Great East Japan Earthquake struck at 2011, very few studies examined the change in psychological distress among those in Fukushima prefecture using the data before and after the disaster. This article is protected by copyright. All rights reserved.
October 15, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30293238/estimating-contribution-of-rare-non-coding-variants-to-neuropsychiatric-disorders
#11
Atsushi Takata
Owing to recent advances in DNA sequencing technology, a number of large-scale comprehensive analyses of genetic variations in protein-coding regions (i.e., whole-exome sequencing studies), have been conducted for neuropsychiatric and neurodevelopmental disorders, such as autism spectrum disorders, intellectual disability, and schizophrenia. These studies, especially those focusing on de novo (newly arising) mutations and extremely rare variants, have successfully identified previously unrecognized disease genes/mutations with a large effect size and deepen our understanding of the biology of neuropsychiatric diseases...
October 6, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30251375/lacosamide-in-bipolar-disorder-a-30-day-comparison-to-a-retrospective-control-group-treated-with-other-antiepileptics
#12
Ilaria Cuomo, Daria Piacentino, Georgios D Kotzalidis, Luana Lionetto, Sergio De Filippis
AIM: Bipolar disorder (BD) is often treated with anticonvulsants. Lacosamide has not been tested in BD. We assessed its effects in a hospital setting in patients with BD without epilepsy. METHODS: We treated 102 consecutive hospitalized patients with acute BD with lacosamide 50-300 mg/day. We compared this sample with a retrospective sample treated with other antiepileptics (OAE). We rated patients after 3, 7, 15, and 30 days of treatment with the Brief Psychiatric Rating Scale, Young Mania Rating Scale, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Clinical Global Impressions - Severity, and Global Assessment of Functioning...
September 24, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30246448/delirium-detection-by-a-novel-bispectral-electroencephalography-device-in-general-hospital
#13
Gen Shinozaki, Aubrey C Chan, Nicholas A Sparr, Kasra Zarei, Lindsey N Gaul, Jonathan T Heinzman, Julian Robles, Kumi Yuki, Theodosis J Chronis, Timothy Ando, Terrence Wong, Sayeh Sabbagh, Michelle T Weckmann, Sangil Lee, Thoru Yamada, Matthew D Karam, Nicolas O Noiseux, Eri Shinozaki, John W Cromwell
AIM: Delirium is common and dangerous among elderly inpatients; yet, it is underdiagnosed and thus undertreated. This study aimed to test the diagnostic characteristics of a noninvasive point-of-care device with two-channel (bispectral) electroencephalography (EEG) for the screening of delirium in the hospital. METHODS: Patients admitted to the University of Iowa Hospitals and Clinics were assessed for the presence of delirium with a clinical assessment, the Confusion Assessment Method for Intensive Care Unit and Delirium Rating Scale...
September 24, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30225953/hemolytic-anemia-potentially-associated-with-aripiprazole-a-case-report
#14
LETTER
Inês Capeto Coelho, Amélia Aleixo, Ludgero Linhares, André Martins, Diogo Telles-Correia
We report a case of a female patient, 48yo, medicated for depressive features with Clomipramine 75mg 1id and Bromazepam 6mg 3id, with the recent addition (8 weeks at admission time) of Aripiprazole 10mg 1id. She started experiencing fatigue, tachycardia, and paleness (symptoms suggestive of anemia) as well as weight loss and dark coloured urine. She presented with macrocytic anemia (Hb 7.7 g/dL, MGV 108.1 fL), leucocytosis (17.160/L), thrombocytosis (612 x109/L) and hyperbilirubinemia (total 1.86mg/dL, direct 0...
September 18, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30225898/association-of-electroconvulsive-therapy-with-psychiatric-readmissions-in-singapore-tertiary-mood-disorder-unit
#15
LETTER
Phern-Chern Tor, Edimansyah Abdin
Electroconvulsive therapy (ECT) may reduce psychiatric readmissions [1]. No similar data is available in Asia hence we investigated the association between ECT and 30-day psychiatric readmission in a tertiary Mood Disorder Unit (MDU) in Singapore. This article is protected by copyright. All rights reserved.
September 18, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30159979/measurement-of-cerebrospinal-fluid-orexin-a-hypocretin-1-by-enzyme-linked-immunosorbent-assay-a-comparison-with-radioimmunoassay
#16
LETTER
Taisuke Ono, Takashi Kanbayashi, Kazuhisa Yoshizawa, Seiji Nishino, Tetsuo Shimizu
No abstract text is available yet for this article.
August 30, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30156046/serum-metabolic-profiling-using-small-molecular-water-soluble-metabolites-in-individuals-with-schizophrenia-a-longitudinal-study-using-a-pre-post-treatment-design
#17
Bing Cao, Min Jin, Elisa Brietzke, Roger S McIntyre, Dongfang Wang, Joshua D Rosenblat, Renee-Marie Ragguett, Chuanbo Zhang, Xiaoyu Sun, Carola Rong, Jingyu Wang
AIM: We sought to compare alterations in serum bioenergetic markers within a well-characterized sample of adults with schizophrenia at baseline and after 8 weeks of pharmacological treatment with the hypothesis that treatment would be associated with significant changes in bioenergetic markers given the role of bioenergetic dysfunction in schizophrenia. METHOD: We recruited adults with schizophrenia (n=122) who had not received pharmacological treatment for at least one month prior to enrollment, including drug naïve (i...
August 29, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30144221/erythropoietin-preparation-drastically-improved-activities-of-daily-living-in-a-patient-with-severe-dementia
#18
LETTER
Ryo Kumagai, Masato Koike, Yoshiyuki Iwase, Yosuke Ichimiya
No abstract text is available yet for this article.
August 25, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30062724/seizure-as-a-primary-presentation-in-opioid-withdrawal
#19
LETTER
Shreyance Jain, Kartik Singhai, Mukesh Swami
No abstract text is available yet for this article.
October 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30039895/hair-pulling-disorder-complicated-by-skin-picking-disorder-an-unknown-side-effect-of-dopamine-replacement-therapy
#20
LETTER
Marie Grall-Bronnec, Gaëlle Challet-Bouju, Juliette Leboucher, Jean-Marc Fève, Marie Le Moigne, Pascal Derkinderen, Caroline Victorri-Vigneau
No abstract text is available yet for this article.
October 2018: Psychiatry and Clinical Neurosciences
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