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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/28317224/pharmacotherapy-for-the-treatment-of-aggression-in-pediatric-and-adolescent-patients-with-autism-spectrum-disorder-comorbid-attention-deficit-hyperactivity-disorder-a-questionnaire-survey-of-571-psychiatrists
#1
Kazuhiko Yamamuro, Noa Tsujii, Toyosaku Ota, Toshifumi Kishimoto, Junzo Iida
AIMS: Both attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are frequently accompanied by serious aggression that requires psychiatric treatment. However, little is known about the experiences psychiatrists have had using pharmacotherapy to treat aggression in patients who have both ASD and ADHD (ASD/ADHD). The purpose of this study was to examine the experiences of Japanese child and adolescent psychiatrists in prescribing medication for aggression in patients with ASD/ADHD...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317220/rare-fbxo18-variations-and-risk-of-schizophrenia-whole-exome-sequencing-in-two-parent-affected-offspring-trios-followed-by-resequencing-and-case-control-studies
#2
Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Emiko Inoue, Hirofumi Igeta, Ikuo Otsuka, Masako Shibuya, Jun Egawa, Ichiro Sora, Toshiyuki Someya
AIM: Rare variations are suggested to play a role in the genetic etiology of schizophrenia, and to further investigate their role, we performed a three-stage study in a Japanese population. METHODS: In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we resequenced the FBXO18 coding region in 96 patients. In the third stage, we tested rare non-synonymous FBXO18 variations for association with schizophrenia in two independent populations comprising a total of 1,376 patients and 1,496 controls...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317219/reliability-and-validity-of-the-california-verbal-learning-test-cvlt-ii-japanese-version
#3
LETTER
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Kitajima Tomoko, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuyuki Nakagome
In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder(1,2)) , the present study tested the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II(3)()) Japanese version.(4)).
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317218/rodent-models-of-genetic-and-chromosomal-variations-in-psychiatric-disorders
#4
Jun Nomura, Geetha Kannan, Toru Takumi
Elucidating the molecular basis of complex human psychiatric disorders is challenging due to the multitude of factors that underpin these disorders. Genetic and chromosomal changes are two factors that have been suggested to be involved in psychiatric disorders. Indeed, numerous risk loci have been identified in autism spectrum disorders (ASD), schizophrenia, and related psychiatric disorders. Here, we introduce genetic animal models that disturb excitatory-inhibitory (E/I) balance in the brain and animal models mirroring human chromosomal abnormalities, both of which may be implicated in ASD pathophysiology...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28295856/factors-affecting-prolonged-length-of-stay-in-psychiatric-patients-in-japan-a-retrospective-observational-study
#5
Daisuke Shinjo, Hisateru Tachimori, Keiko Sakurai, Tetsu Ohnuma, Kenji Fujimori, Kiyohide Fushimi
AIM: Hospital length of stay is one of the stratified measures of health care efficiency and is commonly used to assess performance of psychiatric care. The aim of this study is to identify risk factors for prolonged length of stay of psychiatric patients. METHODS: We retrospectively analyzed adult psychiatric patients (ICD-10; F-00-F99) between April of 2012 and March of 2014 in the Japanese Diagnosis Procedure Combination database. We examined factors affecting prolonged length of stay using multivariable logistic regression analysis...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28294477/identifying-neurocognitive-markers-for-outcome-prediction-of-global-functioning-in-ultra-high-risk-for-psychosis-and-first-episode-psychosis
#6
Kingo Sawada, Akiko Kanehara, Satoshi Eguchi, Mariko Tada, Yoshihiro Satomura, Motomu Suga, Shinsuke Koike, Kiyoto Kasai
AIM: There is an increasing need for identifying neurocognitive predictors of global functional outcome in early psychosis toward optimizing early intervention strategy. METHODS: We conducted a longitudinal observational study to investigate an association between neurocognitive assessments at baseline and global functional outcome at an average of one-year follow-up. Participants included ultra-high-risk for psychosis (UHR) individuals who had not converted to psychosis during the follow-up period (UHR-NP), and those with first-episode psychosis (FEP) individuals...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28294468/memory-impairment-and-the-mediating-role-of-task-difficulty-in-patients-with-schizophrenia
#7
REVIEW
Kyrsten M Grimes, Anosha Zanjani, Konstantine K Zakzanis, C Psych
Using meta-analytic methods, we sought to synthesize the research literature on memory impairment in schizophrenia. Additionally, we compared performances across memory measures to determine if task difficulty (e.g., effortful encoding and retrieval versus non effortful encoding and retrieval) could account for variance across studies. Our primary measures of interest included the California Verbal Learning Test, Wechsler Memory Scale, Rey Auditory Verbal Learning Test, Hopkins Verbal Learning Test, Rey Osterrieth Complex Figure Test, and the Benton Visual Retention Test...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28294480/purinergic-dysfunction-in-bipolar-disorder-any-role-for-the-antioxidant-uric-acid-as-a-trait-and-state-biomarker
#8
LETTER
Francesco Bartoli, Giuseppe Carrà, Massimo Clerici
The valuable overview by Sigitova and colleagues(1) recently published in Psychiatry and Clinical Neurosciences, has extensively examined biological hypotheses of bipolar disorder (BD), reviewing also promising biomarkers for early diagnosis and potential treatments. This comprehensive review can be possibly complemented by growing evidence on the role of uric acid (UA) as a biomarker of BD and related phases,(2,3) similarly to behavioral abnormalities based on genetically determined disorders such as Lesch-Nyhan syndrome...
March 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28233379/optogenetics-applications-in-psychiatric-research
#9
Fukutoshi Shirai, Akiko Hayashi-Takagi
Recently, optogenetic techniques emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics result from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond time scale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine-tuning cannot be achieved using traditional methods...
February 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28220654/longitudinal-study-examining-abnormal-white-matter-integrity-using-a-tract-specific-analysis-in-individuals-with-a-high-risk-for-psychosis
#10
Junichi Saito, Masaaki Hori, Takahiro Nemoto, Naoyuki Katagiri, Keigo Shimoji, Shinya Ito, Naohisa Tsujino, Taiju Yamaguchi, Nobuyuki Shiraga, Shigeki Aoki, Masafumi Mizuno
AIM: Although volume reductions in the grey matter have been previously observed in individuals with an at-risk mental state (ARMS) for psychosis, the features of white matter integrity and their correlation with psychiatric symptoms remain unclear. METHODS: Forty-six ARMS subjects were examined using magnetic resonance imaging (MRI) to acquire diffusion tensor imaging (DTI) images; the subjects were also evaluated using the Scale of Prodromal Symptoms at baseline and at 52 weeks...
February 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28211213/response-to-enrichment-of-deleterious-variants-of-mitochondrial-dna-polymerase-gene-polg1-in-bipolar-disorder
#11
LETTER
Tadafumi Kato, Takaoki Kasahara
No abstract text is available yet for this article.
February 16, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28191687/clinical-pharmacokinetic-interactions-between-lamotrigine-and-hormonal-contraceptives-in-bipolar-i-disorder
#12
LETTER
Ryo Sawagashira, Yutaka Fujii, Ichiro Kusumi
No abstract text is available yet for this article.
February 13, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28182301/factor-analyzing-the-norwegian-matrics-consensus-cognitive-battery
#13
Christine Mohn, June Ullevoldsaeter Lystad, Torill Ueland, Erik Falkum, Bjørn Rishovd Rund
AIM: The MATRICS Consensus Cognitive Battery (MCCB) assesses seven cognitive domains with ten subtests. This domain structure has not been demonstrated. Three factors have been produced in US samples. We examined the dimensional structure of the Norwegian MCCB. In addition, we studied the contribution of each subtest to the battery sum score. METHODS: The participants were 131 patients with schizophrenia spectrum disorders and 300 healthy controls. Their Norwegian MCCB test scores were subject to exploratory and confirmatory factor analysis and regression analysis...
February 9, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28177184/associations-between-renaming-schizophrenia-and-stigma-related-outcomes-a-systematic-review
#14
Sosei Yamaguchi, Masashi Mizuno, Yasutaka Ojio, Utako Sawada, Asami Matsunaga, Shuntaro Ando, Shinsuke Koike
Renaming schizophrenia is a potential strategy to reduce the stigma attached to people with schizophrenia. However, the overall associations between renaming schizophrenia and stigma-related outcomes have not been fully elucidated. We conducted a systematic review of studies that empirically examined the outcomes between new or alternative terms and old or existing terms for schizophrenia. We searched for relevant articles in eight bibliographic databases, conducted a Google search, examined reference lists, and contacted relevant experts...
February 8, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28177178/association-of-premorbid-personality-with-behavioral-and-psychological-symptoms-in-dementia-with-lewy-bodies-comparison-with-alzheimer-s-disease-patients
#15
Kazuki Tabata, Yasuaki Saijo, Fumiyoshi Morikawa, Juichiro Naoe, Eiji Yoshioka, Yasuyuki Kawanishi, Yoshihiko Nakagi, Takahiko Yoshida
AIM: The aim of this study was to elucidate the relationship between premorbid personality traits and behavioral and psychological symptoms in dementia (BPSD) in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) patients. METHODS: Forty-one DLB patients and 98 AD patients were assessed for BPSD using the Neuropsychiatric Inventory (NPI). Each patient's midlife personality traits were rated by a family member using the NEO Five-Factor Inventory (NEO-FFI) questionnaire...
February 8, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28106314/role-of-cytokine-changes-in-clozapine-induced-fever-a-cohort-prospective-study
#16
Yuan-Pin Hung, Carol Sheei-Meei Wang, Chia-Nan Yen, Hsun-Cheng Chang, Po See Chen, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Ru-Band Lu, Tzu-Yun Wang
AIM: Clozapine-associated fever is common but the specific cytokine changes and treatment durations that may cause fever remain unknown. We investigate the association between inflammatory cytokine changes and clozapine-induced fever in patients who were treated with clozapine. METHODS: Forty-three patients with schizophrenia or schizoaffective disorder, diagnosed by using the Chinese Version of the Mini International Neuropsychiatric Interview, were treated with clozapine for the first time (first-time use group, n = 22) or more than 6 months (long-term use group, n = 21)...
January 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28097743/optimizing-outcomes-in-clozapine-rechallenge-following-neutropenia-using-human-leukocyte-antigen-typing-a-case-report
#17
LETTER
Naruhisa Yamaki, Akitoyo Hishimoto, Ikuo Otsuka, Toru Sasada, Shuken Boku, Takeo Saito, Yuka Yasuda, Hidenaga Yamamori, Masashi Ikeda, Manabu Ikeda, Ichiro Sora, Nakao Iwata, Ryota Hashimoto
No abstract text is available yet for this article.
January 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28094461/comparison-of-the-32-item-hypomania-checklist-hcl-32-the-33-item-hypomania-checklist-hcl-33-and-the-mood-disorders-questionnaire-mdq-for-bipolar-disorder
#18
Yuan Feng, Yuan-Yuan Wang, Wei Huang, Gabor S Ungvari, Chee H Ng, Gang Wang, Zhen Yuan, Yu-Tao Xiang
AIM: Bipolar disorder (BD) is frequently misdiagnosed as major depression and hence reliable and culturally appropriate screening tools are needed. This study compared the 32-item Hypomania Checklist (HCL-32), the 33-item Hypomania Checklist (HCL-33), and the Mood Disorders Questionnaire (MDQ) for BD. METHODS: Altogether, 350 depressed patients were included. The HCL-32, the HCL-33 and the MDQ were completed by patients to identify manic and/or hypomanic symptoms...
January 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28094458/inquiring-about-insomnia-may-facilitate-diagnosis-of-depression-in-the-primary-care-setting
#19
Megumi Fujieda, Katsuhisa Uchida, Shinichiro Ikebe, Akihiro Kimura, Masashi Kimura, Toshiaki Watanabe, Hisako Sakamoto, Teruaki Matsumoto, Naohisa Uchimura
AIM: Depression is often undiagnosed in primary care. Asking about sleep status is much easier than asking about mood. This study was conducted to examine the relation between insomnia and depression. METHODS: New patients aged 35-64 years were recruited from internal medicine clinics in Japan. Self-administered questionnaires were employed. Depression was evaluated by the Zung Self-Rating Depression Scale and the Profile of Mood States. Sleep status was investigated using the Pittsburgh Sleep Quality Index...
January 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28039921/right-hemispheric-hyperfrontality-in-schizophrenia-during-a-shiritori-task-an-fmri-study
#20
LETTER
Masayuki Inoue, Yoshihisa Shoji, Takefumi Ueno, Kiichiro Morita, Toshi Abe, Naohisa Uchimura
No abstract text is available yet for this article.
December 30, 2016: Psychiatry and Clinical Neurosciences
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