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Psychiatry and Clinical Neurosciences

Emmanuelle Silva Tavares Sobreira, Manoel Alves Sobreira-Neto, Márcio Alexandre Pena-Pereira, Marcos Hortes N Chagas, Regina Maria França Fernandes, Alan Luiz Eckeli, Vitor Tumas
AIM: Sleep disorders can be associated with an increased risk for cognitive decline in patients with Parkinson's disease (PD). The aim of this study was to examine the association between cognitive status and presence of sleep symptoms and sleep disorders in PD patients. METHODS: We evaluated excessive sleepiness, other sleep symptoms and performed polysomnography and neuropsychological evaluation in 79 patients. They were classified as with normal cognition (PDNC), mild cognitive impairment (PDMCI), or dementia (PDD)...
January 12, 2019: Psychiatry and Clinical Neurosciences
Kuk-In Jang, Jihoon Oh, Wookyoung Jung, Sangmin Lee, Sungkean Kim, Seung Huh, Seung-Hwan Lee, Jeong-Ho Chae
AIM: Electroencephalogram (EEG) alpha activity during resting state reflects the 'readiness' of an individual to respond to the environment, this includes the performance of cognitive processes. Alpha activity is reported to be attenuated in schizophrenia. Understanding the interaction between alpha activity during rest and when cognitively engaged may provide insights to the neural circuitry which is dysfunctional in schizophrenia. This study investigated the changes of alpha activity between resting state and cognitive engagement in patients with schizophrenia...
January 9, 2019: Psychiatry and Clinical Neurosciences
Hwagyu Suh, Byung Dae Lee, Je Min Park, Young Min Lee, Eunsoo Moon, Hee Jeong Jeong, Soo Yeon Kim, Kang Yoon Lee, Young In Chung
AIM: Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of symptom check list (SCL) psychopathologic dimensions in the Korean schizophrenic linkage disequilibrium (LD) families. METHOD: We have recruited 204 probands(with schizophrenia) with their parents and siblings whenever possible...
December 27, 2018: Psychiatry and Clinical Neurosciences
Naohiro Okada, Shuntaro Ando, Motoyuki Sanada, Sachiko Hirata-Mogi, Yudai Iijima, Hiroshi Sugiyama, Toru Shirakawa, Mika Yamagishi, Akiko Kanehara, Masaya Morita, Tomoko Yagi, Noriyuki Hayashi, Daisuke Koshiyama, Kentaro Morita, Kingo Sawada, Tempei Ikegame, Noriko Sugimoto, Rie Toriyama, Mio Masaoka, Shinya Fujikawa, Sho Kanata, Mariko Tada, Kenji Kirihara, Noriaki Yahata, Tsuyoshi Araki, Seiichiro Jinde, Yukiko Kano, Shinsuke Koike, Kaori Endo, Syudo Yamasaki, Atsushi Nishida, Mariko Hiraiwa-Hasegawa, Miki Bundo, Kazuya Iwamoto, Saori C Tanaka, Kiyoto Kasai
AIM: Adolescence is a crucial stage of psychological development and is critically vulnerable to the onset of psychopathology. However, our understanding of how maturation of endocrine, epigenetics, and brain circuit may underlie the psychological development in adolescence has not been integrated. Here, we introduce our research project, the "population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC)," a longitudinal study to explore the neurobiological substrates of development during adolescence...
December 27, 2018: Psychiatry and Clinical Neurosciences
Claudio Liguori, Monica Moresco, Francesca Izzi, Nicola Biagio Mercuri, Giuseppe Plazzi, Fabio Placidi
We read the recent paper published in Your Psychiatry and Clinical Neurosciences Journal by Dr. Ono and co-Authors showing the possibility to measure CSF orexin-A levels by using the enzyme-linked immunosorbent assay (ELISA) instead of radioimmunoassay (RIA). This article is protected by copyright. All rights reserved.
December 26, 2018: Psychiatry and Clinical Neurosciences
Takashi Terada, Hitoshi Kawano, Masanori Nagamine, Jun Shigemura, Mitsue Nagamine
Psychological resilience is a crucial element in recovery from stressful experiences. Approaches to enhance resilience have been taken in the field of occupational medicine, but resilience rating scales focusing on worker populations are few. This article is protected by copyright. All rights reserved.
December 26, 2018: Psychiatry and Clinical Neurosciences
Chih-Ming Cheng, Shuu-Jiun Wang, Tung-Ping Su, Mu-Hong Chen, Jen-Chuen Hsieh, Shung-Tai Ho, Ya-Mei Bai, Nien-Tzu Kao, Wen-Han Chang, Cheng-Ta Li
AIM: Fibromyalgia is often comorbid with depression, and less than half those patients achieve satisfactory improvement after adequate pharmacological intervention. The investigation of repetitive transcranial magnetic stimulation(rTMS) at left dorsolateral prefrontal cortex for modified-2010 AmericanCollege of Rheumatology(ACR) fibromyalgia and major depressive disorder(MDD) is still in it's infancy. METHODS: In this double-blind, randomized, sham-control study, subjects diagnosed with ACR-2010 fibromyalgia and DSM-IV-TR MDD were recruited and received either active or sham interventions for two weeks...
December 26, 2018: Psychiatry and Clinical Neurosciences
Takuto Ishida, Kazuki Miyazaki, Takahiro Yukawa, Toshinobu Yamagishi, Kazuhiro Sugiyama, Takahiro Tanabe, Yuichi Hamabe, Masaru Mimura, Takefumi Suzuki, Hiroyuki Uchida
AIM: Although sudden cardiac deaths have been reportedly more common among psychiatric patients than the general population, data on their causes are very limited. The aim of this study was to investigate initial rhythms and causes of out-of-hospital cardiac arrest (OHCA) among patients with psychiatric disorders. METHODS: We conducted a systematic chart review of patients resuscitated after OHCA and hospitalized in the Tertiary Emergency Medical Center of Tokyo Metropolitan Bokutoh Hospital in Japan between January 2010 and December 2017...
December 26, 2018: Psychiatry and Clinical Neurosciences
Bin Feng, Ying Zhang, Li-Yuan Luo, Jian-Yong Wu, Sen-Jun Yang, Ning Zhang, Qing-Rong Tan, Hua-Ning Wang, Nan Ge, Fan Ning, Zi-Li Zheng, Rui-Ming Zhu, Min-Cai Qian, Zhi-Yu Chen, Zhang-Jin Zhang
AIM: Transcutaneous electrical acupoint stimulation (TEAS) has the potential to alleviate posttraumatic stress disorder (PTSD). The purpose of this study was to determine whether adding TEAS to sertraline or cognitive behavioral therapy (CBT) could improve the anti-PTSD efficacy. METHODS: In this randomized controlled trial, 240 PTSD patients with 60 each group were assigned to receive simulated TEAS combined with sertraline (Group A) or CBT (Group B), active TEAS combined with CBT (Group C), and active TEAS combined with CBT plus sertraline (Group D) for 12 weeks...
December 19, 2018: Psychiatry and Clinical Neurosciences
Christian Geretsegger, Eva-Maria Pichler, Kathrin Gimpl, Wolfgang Aichhorn, Renate Stelzig, Gertrud Grabher-Stoeffler, Christoph Hiemke, Gerald Zernig
AIMS: Non-adherence or partial adherence to psychotropic medication is found in 18-70% of patients. However, many previously used methods for the assessment of adherence (e.g., questionnaires, pill counts, and electronic systems) might underreport actual rates of non-adherence to medication. Target was to quantify adherence using plasma-levels. METHODS: We conducted a six-week prospective study of all consecutive admitted patients at the Paracelsus Medical University of Salzburg, Clinics of Psychiatry and Psychotherapy, who had been treated with antipsychotics/antidepressants prior to admission (pre-medication dosage in 161 of 233)...
December 15, 2018: Psychiatry and Clinical Neurosciences
Tatsuo Akechi, Tadashi Kato, Norio Watanabe, Shiro Tanaka, Toshi A Furukawa
Most patients with bipolar disorder have depressive onset polarity. There is, however, very few studies investigating predictors of hypomanic and/or manic change for patients with major depression in Japan.1 We preliminary explored predictors of hypomanic and/or manic switch during acute phase antidepressants treatment by using the data of the SUND trial that is a multi-center randomized controlled clinical trial. Total of 2011 patients participated and the main findings are published elsewhere.2 This article is protected by copyright...
December 9, 2018: Psychiatry and Clinical Neurosciences
Ching-Wen Chu, Chih-Sung Liang
Diphenhydramine is a potentially addictive medication. Because the route of administration significantly affects drug delivery to the brain, intramuscular injection of diphenhydramine can trigger more euphoric and rewarding effect, facilitating dependence liability.1 Like narcotics, diphenhydramine is used in a variety of medical conditions, and an underlying disorder may mask the dependence.2 Moreover, diphenhydramine dependence may be overlooked, as it is an over-the-counter medication. This article is protected by copyright...
December 7, 2018: Psychiatry and Clinical Neurosciences
Masaaki Tanichi, Masanori Nagamine, Jun Shigemura, Taisuke Yamamoto, Takehito Sawamura, Yoshitomo Takahashi, Asuka Obara, Taku Saito, Hiroyuki Toda, Aihide Yoshino, Kunio Shimizu
AIM: The importance of family care during international deployment is emphasized within military organizations, but mental health interactions between deployed personnel and their spouses have not yet been assessed. This study addressed this gap by examining couples' mental health throughout a deployment period. METHODS: The mental health of 324 spousal dyads of Japan Self-Defense Forces personnel dispatched for a half-year United Nations Disengagement Observer Force mission was examined, using longitudinal data derived from a survey at four time points: one-month pre-deployment, initial deployment, middle deployment, and immediately after homecoming...
December 3, 2018: Psychiatry and Clinical Neurosciences
Ibrahim Nadeem, Mohammed Zohair Rahman, Yasser Ad-Dab'bagh, Mahmood Akhtar
Depression is one of the most prevalent mental illnesses and is often associated with various other medical disorders. Since the 1980s, the primary pharmacological treatment has been antidepressants, but due to the recent discovery of the association between the gut microbiome and mental health, probiotics have been proposed as an adjunctive or alternate treatment. In this narrative review, we aim to provide a holistic perspective by synthesizing and evaluating existing evidence, discussing key biological mechanisms, exploring the history of probiotic use and appreciating the influence of modern diet on mental health...
November 29, 2018: Psychiatry and Clinical Neurosciences
Hideaki Tani, Mitsuhiro Tada, Takaki Maeda, Mika Konishi, Satoshi Umeda, Yuri Terasawa, Masaru Mimura, Takuya Takahashi, Hiroyuki Uchida
AIM: While emotional processing is implicated in various psychiatric illnesses, its differences among diagnoses are unclear. We compared associative learning of social values in patients with depression and schizophrenia by measuring skin conductance response (SCR) to the interpersonal stimuli. METHODS: We included twenty female outpatients each with depression and schizophrenia. They underwent Pavlovian conditioning experiments in response to a classical aversive sound, and an interpersonal stimulus that was designed to cause aversive social conditioning with actors' faces coupled with negative verbal messages...
November 29, 2018: Psychiatry and Clinical Neurosciences
Sina Naderi, Heidar Faghih, Ali Aqamolaei, Seyyed Hosein Mortazavi, Amirhosein Mortezaei, Erfan Sahebolzamani, Farzin Rezaei, Shahin Akhondzadeh
AIM: Role of the glutamatergic system in pathogenesis of obsessive-compulsive disorder (OCD) has been shown by numerous studies. The aim of the present randomized, double-blind, placebo-controlled, 12-week trial was to assess the efficacy and tolerability of amantadine as an adjuvant to fluvoxamine in treatment of patients with moderate to severe OCD. METHODS: One hundred patients diagnosed with moderate to severe OCD were randomized into two parallel groups to receive fluvoxamine (100 mg twice a day) plus placebo or fluvoxamine (100 mg twice a day) plus amantadine (100 mg daily) for 12 weeks...
November 28, 2018: Psychiatry and Clinical Neurosciences
Fang-Ling Li, Ta-Chuan Yeh, Fu-Chi Yang, Chih-Sung Liang
Real-world data have shown that clozapine and long-acting injectable (LAI) antipsychotics (LAIAs) were more effective than oral antipsychotics in preventing relapse in schizophrenia.1 A treatment dilemma emerges when managing patients with treatment-resistant schizophrenia (TRS) refusing oral antipsychotics, as the treatment of choice, LAI clozapine, is not available. We reported on two patients with TRS successfully managed with combined typical and atypical LAIAs. Informed consents have been obtained from both patients' family...
November 25, 2018: Psychiatry and Clinical Neurosciences
En-Ting Chang, Shih-Fen Chen, Jen-Huai Chiang, Ling-Yi Wang, Chung-Y Hsu, Yu-Chih Shen
AIM: Previous studies have found a high prevalence of risk factors for obstructive sleep apnea (OSA) in patients with bipolar disorder (BD). The study aims to determine whether BD patients are associated with an increased risk of incident OSA. METHODS: Using the National Health Insurance Research Database (NHIRD) of Taiwan, 3,650 BD patients and 18,250 non-BD controls matched by gender and age were enrolled between 2000-2010 and followed until the end of 2013. Patients who developed OSA confirmed by a polysomnographic examination during the follow-up period were identified...
November 25, 2018: Psychiatry and Clinical Neurosciences
Tomoya Hirota, Anthony Guerrero, Norman Sartorius, Daniel Fung, Bennett Leventhal, Say How Ong, Hitoshi Kaneko, Suporn Apinuntavech, Abang Bennett, Jegannathan Bhoomikumar, Keun-Ah Cheon, Oyunsuren Davaasuren, Susan Gau, Brian Hall, Evgeny Koren, Tuan van Nguyen, Tin Oo, Susan Tan, Masaru Tateno, Manivone Thikeo, Tjhin Wiguna, Mark Wong, Yi Zheng, Norbert Skokauskas
AIM: Data pertaining to Child and Adolescent Psychiatry (CAP) training systems are limited as extant research was mostly derived from a one-time data collection. This 5-year follow-up survey collects updated information on CAP training systems in the Far East, allowing for the tracking of system changes over the past 5 years. METHODS: Data were obtained from 18 countries, or functionally self-governing areas, in the Far East, 17 of which were also included in the original study...
November 24, 2018: Psychiatry and Clinical Neurosciences
Karol Grabowski, Agnieszka Rynkiewicz, Amandine Lassalle, Simon Baron-Cohen, Björn Schuller, Nicholas Cummins, Alice E Baird, Justyna Podgórska-Bednarz, Agata Pieniążek, Izabela Łucka
AIM: Emotional expressions are one of the most widely studied topics in neuroscience, both from clinical and non-clinical perspective. Atypical emotion expressions are seen in various psychiatric conditions including schizophrenia, depression and autism spectrum conditions. Understanding the basics of emotions expressions and recognition can be crucial for diagnostic and therapeutic procedures. Emotions can be expressed in the face, gesture, posture, voice, behaviour and effect physiological parameters such as the heart rate or the body temperature...
November 22, 2018: Psychiatry and Clinical Neurosciences
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