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Psychiatry and Clinical Neurosciences

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https://www.readbyqxmd.com/read/28523821/risk-factors-for-early-cardiovascular-mortality-in-patients-with-bipolar-disorder
#1
Shang-Ying Tsai, Chao-Hsien Lee, Pao-Huan Chen, Kuo-Hsuan Chung, Shou-Hung Huang, Chian-Jue Kuo, Wen-Cheng Wu
AIM: We attempted to determine risk factors, particularly pathophysiological changes, for the early cardiovascular mortality in bipolar disorder. METHODS: A total of 5416 in-patients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD, ICD 9: 401-443) before the age of 65 years were identified. Two living bipolar patients and two mentally healthy adults were matched with each one deceased patient as control subjects according to age (±2 years), sex, and date (±3 years) of the final/index admission or the date of general health screening...
May 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28523718/does-sleep-disturbance-affect-the-amyloid-clearance-mechanisms-in-alzheimer-s-disease
#2
REVIEW
Burak Yulug, Lutfu Hanoglu, Ertugrul Kilic
Sleep is one of the important factors that play a key role in AD pathogenesis. However, it is still unclear whether poor quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in amyloid beta (Aβ) clearance metabolism. To that end, we discussed possible mechanisms underlying the bidirectional interaction between the sleep deprivation and amyloid beta (Aβ) clearance pathways...
May 18, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28459504/verbal-memory-impairments-in-bipolar-disorder-effect-of-type-of-word-learning-tasks
#3
LETTER
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
Disturbances of cognitive functions, including verbal (learning) memory, in bipolar disorder have attracted interest.(1,2)) The present study was conducted to determine if type of word learning tasks, i.e. whether or not evaluation is based on a word list with categorized items, affects severity of impairment of verbal memory in patients with bipolar disorder.
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28459134/differences-in-neural-responses-to-reward-and-punishment-processing-between-anorexia-nervosa-subtypes-an-fmri-study
#4
Ema Murao, Genichi Sugihara, Masanori Isobe, Tomomi Noda, Michiko Kawabata, Noriko Matsukawa, Hidehiko Takahashi, Toshiya Murai, Shun'ichi Noma
AIM: Anorexia nervosa (AN) includes the restricting (AN-r) and binge-eating/purging (AN-bp) subtypes, which have been reported to differ regarding their underlying pathophysiologies as well as their behavioral patterns. However, the differences in neural mechanisms of reward systems between AN subtypes remain unclear. The aim of the present study was to explore differences in the neural processing of reward and punishment between AN subtypes. METHODS: Twenty-three female patients with AN (11 AN-r and 12 AN-bp) and 20 healthy women underwent functional magnetic resonance imaging while performing a monetary incentive delay task...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28457018/modulation-of-the-n400-component-in-relation-to-hypomanic-personality-traits-in-a-word-meaning-ambiguity-resolution-task
#5
Delphine Raucher-Chéné, Sarah Terrien, Pamela Gobin, Fabien Gierski, Arthur Kaladjian, Chrystel Besche-Richard
AIM: High levels of hypomanic personality traits have been associated with an increased risk of developing bipolar disorder (BD). Changes in semantic content, impaired verbal associations, abnormal prosody and abnormal speed of language are core features of BD, and are thought to be related to semantic processing abnormalities. In the present study, we used event-related potentials to investigate the relationship between semantic processing (N400 component) and hypomanic personality traits...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28457001/plasma-copeptin-and-metabolic-dysfunction-in-individuals-with-bipolar-disorder
#6
Rodrigo B Mansur, Lucas B Rizzo, Camila M Santos, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Roger S McIntyre, Elisa Brietzke
AIM: This study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relationship between copeptin and metabolic parameters. METHODS: We measured plasma levels of copeptin in individuals with BD (N = 55) and healthy controls (N = 21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured...
April 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28436212/cross-sectional-and-longitudinal-epidemiological-studies-of-internet-gaming-disorder-a-systematic-review-of-the-literature
#7
REVIEW
Satoko Mihara, Susumu Higuchi
AIM: The diagnostic criteria of Internet Gaming Disorder (IGD) have been included in section III of DSM-5. This study aims to systematically review both cross-sectional and longitudinal epidemiological studies of IGD. METHODS: All publications included in PubMed and PsychINFO up to May 2016 were systematically searched to identify cross-sectional studies on prevalence and longitudinal studies of IGD. In the process of identification, articles in non-English languages, and studies focusing solely on the use of gaming were excluded, and those meeting the methodological requirements set by this review were included...
April 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28419638/a-diffusion-tensor-imaging-tractography-study-in-bipolar-disorder-patients-compared-to-first-degree-relatives-and-healthy-controls
#8
Ananya Mahapatra, Sudhir Kumar Khandelwal, Pratap Sharan, Ajay Garg, N K Mishra
AIM: To compare white matter structural changes in specific tracts by diffusion tensor imaging (DTI) tractography in patients of bipolar disorder I, non-ill first degree relatives of the patients, and healthy controls. METHODS: In a cross sectional study, we studied right-handed subjects consisting of 16 euthymic bipolar disorder I patients, 15 first degree relatives and 15 healthy controls. The anterior thalamic radiation, uncinate fasciculus, corpus callosum, and cingulum bundle were reconstructed by DTI tractography...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28419623/cognitive-component-of-psychomotor-retardation-in-unipolar-and-bipolar-depression-is-verbal-fluency-a-relevant-marker-impact-of-repetitive-transcranial-stimulation
#9
Véronique Thomas-Ollivier, Emmanuelle Foyer, Samuel Bulteau, Anne Pichot, Pierre Valriviere, Anne Sauvaget, Thibault Deschamps
AIMS: In the literature, psychomotor retardation (PMR) is increasingly highlighted as a relevant marker for depression. Currently, we chose to focus on the fluency capacities as an evaluation of the frontal lobes functioning to reach a better understanding of cognitive and neurobiological mechanisms involved in PMR in depression. The aims of this study were 1) to explore the cognitive component of PMR through the analysis of Verbal Fluency (VF) performance in unipolar and bipolar depression; 2) to examine whether a repetitive transcranial magnetic stimulation (rTMS) treatment can improve concomitantly the RPM and VF capacities, as a relevant marker characteristic of the cognitive component of PMR...
April 17, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28393474/application-of-ipscs-to-understand-neurobiological-basis-of-bipolar-disorder-and-schizophrenia
#10
Yao-Nan Liu, Si-Yao Lu, Jun Yao
The etiology of neuropsychiatric disorders such as schizophrenia and bipolar disorder usually involves complex combinations of genetic defects/variations and environmental impacts, which hindered, for a long time, research efforts based on animal models and patients' non-neuronal cells or postmortem tissues. However, the development of human induced pluripotent stem cell technology by the Yamanaka group was immediately applied to establish cell research models for neuronal disorders. Since then, techniques to achieve highly efficient differentiation of different types of neural cells following iPSC modeling have made much progress...
April 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28370805/progressive-brain-atrophy-and-cognitive-decline-along-with-multiple-episodes-of-delirium
#11
LETTER
Kohei Hayakawa, Takahiro A Kato, Shigeru Imamura, Naofumi Kasai, Shigenobu Kanba
Delirium induces various problems including prolonged cognitive impairment of which the pathophysiology is unknown.1 We report progressive brain atrophy and cognitive decline along with multiple episodes of delirium within two years of admission. The patient gave informed consent and his anonymity has been preserved.
March 29, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317224/pharmacotherapy-for-the-treatment-of-aggression-in-pediatric-and-adolescent-patients-with-autism-spectrum-disorder-comorbid-attention-deficit-hyperactivity-disorder-a-questionnaire-survey-of-571-psychiatrists
#12
Kazuhiko Yamamuro, Noa Tsujii, Toyosaku Ota, Toshifumi Kishimoto, Junzo Iida
AIMS: Both attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are frequently accompanied by serious aggression that requires psychiatric treatment. However, little is known about the experiences psychiatrists have had using pharmacotherapy to treat aggression in patients who have both ASD and ADHD (ASD/ADHD). The purpose of this study was to examine the experiences of Japanese child and adolescent psychiatrists in prescribing medication for aggression in patients with ASD/ADHD...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317220/rare-fbxo18-variations-and-risk-of-schizophrenia-whole-exome-sequencing-in-two-parent-affected-offspring-trios-followed-by-resequencing-and-case-control-studies
#13
Satoshi Hoya, Yuichiro Watanabe, Akitoyo Hishimoto, Ayako Nunokawa, Emiko Inoue, Hirofumi Igeta, Ikuo Otsuka, Masako Shibuya, Jun Egawa, Ichiro Sora, Toshiyuki Someya
AIM: Rare variations are suggested to play a role in the genetic etiology of schizophrenia; to further investigate their role, we performed a three-stage study in a Japanese population. METHODS: In the first stage, we performed whole-exome sequencing (WES) of two parent-affected offspring trios. In the second stage, we resequenced the FBXO18 coding region in 96 patients. In the third stage, we tested rare non-synonymous FBXO18 variations for association with schizophrenia in two independent populations comprising a total of 1376 patients and 1496 controls...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317219/reliability-and-validity-of-the-california-verbal-learning-test-ii-japanese-version
#14
LETTER
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuyuki Nakagome
No abstract text is available yet for this article.
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28317218/rodent-models-of-genetic-and-chromosomal-variations-in-psychiatric-disorders
#15
Jun Nomura, Geetha Kannan, Toru Takumi
Elucidating the molecular basis of complex human psychiatric disorders is challenging due to the multitude of factors that underpin these disorders. Genetic and chromosomal changes are two factors that have been suggested to be involved in psychiatric disorders. Indeed, numerous risk loci have been identified in autism spectrum disorders, schizophrenia, and related psychiatric disorders. Here, we introduce genetic animal models that disturb excitatory-inhibitory balance in the brain and animal models mirroring human chromosomal abnormalities, both of which may be implicated in autism spectrum disorder pathophysiology...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28295856/factors-affecting-prolonged-length-of-stay-in-psychiatric-patients-in-japan-a-retrospective-observational-study
#16
Daisuke Shinjo, Hisateru Tachimori, Keiko Sakurai, Tetsu Ohnuma, Kenji Fujimori, Kiyohide Fushimi
AIM: Hospital length of stay (LOS) is one of the stratified measures of health-care efficiency and is commonly used to assess performance of psychiatric care. The aim of this study was to identify risk factors for prolonged LOS of psychiatric patients. METHODS: We retrospectively analyzed adult psychiatric patients (ICD-10; F00-F99) between April 2012 and March 2014 in the Japanese Diagnosis Procedure Combination database. We examined factors affecting prolonged LOS using multivariable logistic regression analysis...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28294468/memory-impairment-and-the-mediating-role-of-task-difficulty-in-patients-with-schizophrenia
#17
REVIEW
Kyrsten M Grimes, Anosha Zanjani, Konstantine K Zakzanis, C Psych
Using meta-analytic methods, we sought to synthesize the research literature on memory impairment in schizophrenia. Additionally, we compared performances across memory measures to determine if task difficulty (e.g., effortful encoding and retrieval versus non effortful encoding and retrieval) could account for variance across studies. Our primary measures of interest included the California Verbal Learning Test, Wechsler Memory Scale, Rey Auditory Verbal Learning Test, Hopkins Verbal Learning Test, Rey Osterrieth Complex Figure Test, and the Benton Visual Retention Test...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28294480/purinergic-dysfunction-in-bipolar-disorder-any-role-for-the-antioxidant-uric-acid-as-a-trait-and-state-biomarker
#18
LETTER
Francesco Bartoli, Giuseppe Carrà, Massimo Clerici
No abstract text is available yet for this article.
March 10, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28233379/optogenetics-applications-in-psychiatric-research
#19
Fukutoshi Shirai, Akiko Hayashi-Takagi
Recently, optogenetic techniques have emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics results from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond timescale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine-tuning cannot be achieved using traditional methods...
February 24, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28470914/cognitive-impairment-in-psychiatric-disorders
#20
EDITORIAL
Kazuyuki Nakagome
No abstract text is available yet for this article.
May 2017: Psychiatry and Clinical Neurosciences
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