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Hong Kong Medical Journal, Xianggang Yi Xue za Zhi

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https://www.readbyqxmd.com/read/28862145/expanded-newborn-metabolic-screening-programme-in-hong-kong-a-three-year-journey
#1
S C Chong, L K Law, J Hui, C Y Lai, T Y Leung, Y P Yuen
INTRODUCTION: No universal expanded newborn screening service for inborn errors of metabolism is available in Hong Kong despite its long history in developed western countries and rapid development in neighbouring Asian countries. To increase the local awareness and preparedness, the Centre of Inborn Errors of Metabolism of the Chinese University of Hong Kong started a private inborn errors of metabolism screening programme in July 2013. This study aimed to describe the results and implementation of this screening programme...
September 1, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28862144/beating-guangdong-cancer-a-review-and-update-on-nasopharyngeal-cancer
#2
REVIEW
C S Ho
Once endemic in southern China, nasopharyngeal cancer is becoming less prevalent in Hong Kong. This is probably due to a better understanding of the risk factors associated with the disease, its genomic landscape, advances in radiotherapy technology, and development of effective systemic agents. More specifically, the close relationship between Epstein-Barr virus and nasopharyngeal cancer opens up the possibility of using Epstein-Barr virus DNA as a biomarker for early detection and monitoring of the disease...
September 1, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28862143/immunoglobulin-g4-related-disease-in-hong-kong-clinical-features-treatment-practices-and-its-association-with-multisystem-disease
#3
P H Li, K L Ko, C T Ho, L L Lau, R K Tsang, T T Cheung, W K Leung, C S Lau
INTRODUCTION: Immunoglobulin G4-related disease remains an under-recognised and evolving disease. Local data are sparse and previous publications have been limited to individual case reports or case series only. We conducted this study to review the clinical features, treatment practices, and factors associated with multisystem involvement in Hong Kong. We described the clinical features and treatment modalities of the largest cohort of immunoglobulin G4-related disease in our locality thus far...
September 1, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28862142/cancer-screening-for-older-people-to-screen-or-not-to-screen
#4
REVIEW
C Ky Lai, A Igarashi, N My Lau, C Tk Yu
In this scoping review, the evidence of the benefits of screening older people for the five most common types of cancer in Hong Kong, namely colorectal, lung, breast, liver, and prostate cancers, will be discussed. Although cancer treatments can be extensive and a good prognosis is less likely if cancer is diagnosed at a late stage, screening programmes for older people in primary care remain a matter of contention. The general recommendation for the screening of older people is to adopt an individualised approach that takes account of not only age but also co-morbidity, life expectancy, harms and benefits, and patient's preference...
September 1, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28839120/occupational-stress-and-burnout-among-hong-kong-dentists
#5
H B Choy, M C Wong
INTRODUCTION: Professional burnout has been described as a gradual erosion of a person and may be one of the possible consequences of chronic occupational stress. Although occupational stress has been surveyed among dentists in Hong Kong, no study has been published about burnout in the profession. This study aimed to evaluate burnout among Hong Kong dentists and its association with occupational stress. METHODS: We surveyed a random sample of 1086 registered dentists in Hong Kong, which formed 50% of the local profession...
August 25, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28798282/feasibility-and-safety-of-extended-adjuvant-temozolomide-beyond-six-cycles-for-patients-with-glioblastoma
#6
S Yp Hsieh, D Tm Chan, M Km Kam, H Hf Loong, W K Tsang, D Mc Poon, S Cp Ng, W S Poon
INTRODUCTION: Temozolomide is the first chemotherapeutic agent proven effective for patients with newly diagnosed glioblastoma. The drug is well tolerated for its low toxicity. The current standard practice is concomitant chemoradiotherapy for 6 weeks followed by 6 cycles of adjuvant temozolomide. Some Caucasian studies have suggested that patients might benefit from extended adjuvant cycles of temozolomide (>6 cycles) to lengthen both progression-free survival and overall survival...
August 11, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28775219/assessment-of-dietary-food-and-nutrient-intake-and-bone-density-in-children-with-eczema
#7
T F Leung, S S Wang, F Y Kwok, L W Leung, C M Chow, E K Hon
INTRODUCTION: Dietary restrictions are common among patients with eczema, and such practice may lead to diminished bone mineral density. This study investigated dietary intake and bone mineral density in Hong Kong Chinese children with eczema. METHODS: This cross-sectional and observational study was conducted in a university-affiliated teaching hospital in Hong Kong. Chinese children aged below 18 years with physician-diagnosed eczema were recruited from our paediatric allergy and dermatology clinics over a 6-month period in 2012...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28775218/predictive-factors-for-length-of-hospital-stay-following-primary-total-knee-replacement-in-a-total-joint-replacement-centre-in-hong-kong
#8
C K Lo, Q J Lee, Y C Wong
INTRODUCTION: The demand for total knee replacement in Hong Kong places tremendous economic burden on our health care system. Shortening hospital stay reduces the associated cost. The aim of this study was to identify perioperative predictors of length of hospital stay following primary total knee replacement performed at a high-volume centre in Hong Kong. METHODS: We retrospectively reviewed all primary total knee replacements performed at Yan Chai Hospital Total Joint Replacement Centre from October 2011 to October 2015...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28775217/end-of-life-services-for-older-people-in-residential-care-homes-in-hong-kong
#9
REVIEW
J K Luk
Good end-of-life care is needed for older people living in residential care homes with advanced irreversible chronic medical illnesses and cancers. At present, the usual practice of residential care homes is to send older residents to acute hospitals when they are unwell, and some residents will die in hospital. Dying in hospital without choice for older people may not be in alignment with the principle of 'good death'. There are many barriers for older people to die in the place of their choice, particularly in a residential care home...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28775216/surgical-outcome-of-daytime-and-out-of-hours-surgery-for-elderly-patients-with-hip-fracture
#10
Y M Chan, N Tang, S K Chow
INTRODUCTION: Surgery for hip fracture is performed out-of-hours to avoid surgical delay. There is, however, a perception that this may constitute less-than-ideal conditions and result in a poorer outcome. The aim of this study was to evaluate the surgical outcome of elderly patients with hip fracture who underwent daytime versus out-of-hours surgery in Hong Kong. This will help make decisions about whether to operate out-of-hours or to delay surgery until the following day. METHODS: This retrospective study included all elderly patients with hip fracture who were operated on and discharged from Princes of Wales Hospital in 2014...
August 4, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28684651/secular-trends-in-caesarean-section-rates-over-20-years-in-a-regional-obstetric-unit-in-hong-kong
#11
W H Chung, C W Kong, W Wk To
INTRODUCTION: Although caesarean section rates have been increasing over the years in both public and private sectors in Hong Kong, there has been a paucity of formal surveys on local trends in such rates. This study aimed to examine the trends in caesarean section rates over a 20-year period at a public regional obstetric unit in Hong Kong using the Robson's Ten-group Classification System. METHODS: All deliveries in a single obstetric unit during a 20-year period (1995-2014) were classified into 10 subgroups according to the Robson's classification...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28684650/are-we-making-good-use-of-our-public-resources-the-false-positive-rate-of-screening-by-fundus-photography-for-diabetic-macular-oedema
#12
R Lm Wong, C W Tsang, D Sh Wong, S McGhee, C H Lam, J Lian, J Wy Lee, J Sm Lai, V Chong, I Yh Wong
INTRODUCTION: A large proportion of patients diagnosed with diabetic maculopathy using fundus photography and hence referred to specialist clinics following the current screening guidelines adopted in Hong Kong and United Kingdom are found to be false-positive, implying that they did not have macular oedema. This study aimed to evaluate the false-positive rate of diabetic maculopathy screening using the objective optical coherence tomography scan. METHODS: This was a cross-sectional observational study...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28684649/neonatal-outcomes-of-preterm-or-very-low-birth-weight-infants-over-a-decade-from-queen-mary-hospital-hong-kong-comparison-with-the-vermont-oxford-network
#13
Y Y Chee, M Sc Wong, R Ms Wong, K Y Wong
INTRODUCTION: There is a paucity of local data on neonatal outcomes of preterm/very-low-birth-weight infants in Hong Kong. This study aimed to evaluate the survival rate on discharge and morbidity of preterm/very-low-birth-weight infants (≤29+6 weeks and/or birth weight <1500 g) over a decade at Queen Mary Hospital in Hong Kong, so as to provide centre-specific data for prenatal counselling and to benchmark these results against the Vermont Oxford Network. METHODS: Standardised perinatal/neonatal data were collected for 449 infants with gestational age of 23+0 to 29+6 weeks and/or birth weight of <1500 g who were born at Queen Mary Hospital between 1 January 2005 and 31 December 2014...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28684648/a-cross-sectional-study-of-the-knowledge-attitude-and-practice-of-patients-aged-50-years-or-above-towards-herpes-zoster-in-an-out-patient-setting
#14
A Cy Lam, M Y Chan, H Y Chou, S Y Ho, H L Li, C Y Lo, K F Shek, S Y To, K K Yam, I Yeung
INTRODUCTION: There has been limited research on the knowledge of and attitudes about herpes zoster in the Hong Kong population. This study aimed to investigate the knowledge, attitude, and practice of patients aged 50 years or above towards herpes zoster and its vaccination. METHODS: This was a cross-sectional study in the format of a structured questionnaire interview carried out in Sai Ying Pun Jockey Club General Outpatient Clinic in Hong Kong. Knowledge of herpes zoster and its vaccination was assessed, and patient attitudes to and concerns about the disease were evaluated...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28684647/hypersensitivity-to-antipyretics-pathogenesis-diagnosis-and-management
#15
REVIEW
Q U Lee
Antipyretics are commonly prescribed drugs and hypersensitivity occurs at rates of 0.01% to 0.3%. Hypersensitivity can be due to immune mechanisms that include type I to IV hypersensitivity. Type I hypersensitivity results from specific immunoglobulin E production following sensitisation on first exposure. Subsequent exposures elicit degranulation of mast cells, culminating an immediate reaction. Non-type I hypersensitivity is a delayed reaction that involves various effector cells, resulting in maculopapular rash, fixed drug eruptions, drug reaction with eosinophilia and systemic symptoms, and Stevens-Johnson syndrome/toxic epidermal necrolysis...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943526/functional-profiling-and-strategic-antimicrobial-manipulation-of-a-universal-nutrition-sensing-network-to-regulate-microbial-virulence-antibiotic-tolerance-and-stress-protection
#16
E Wc Chan, M Tk Au, R Cy Chan
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943525/synergists-from-portulaca-oleracea-with-macrolides-against-methicillin-resistant-staphylococcus-aureus-and-related-mechanism
#17
K P Fung, Q B Han, M Ip, X S Yang, C Bs Lau, B Cl Chan
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943524/sonodynamic-bactericidal-efficacy-of-hypocrellin-a-and-b-against-methicillin-resistant-staphylococcus-aureus
#18
A Wn Leung, M Ip, C S Xu, X N Wang, P T Yung, H Y Hua
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943523/epidemiology-of-hepatitis-e-infection-in-hong-kong
#19
D Pc Chan, K Ck Lee, S S Lee
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28943522/community-based-molecular-epidemiology-study-of-hepatitis-c-virus-infection-in-injection-drug-users
#20
D Pc Chan, K Ck Lee, S S Lee, T Y Tan
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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