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Redox Report: Communications in Free Radical Research

Angelina Freitas Siqueira, Amilton Vieira, Gracielle Vieira Ramos, Rita de Cássia Marqueti, Tania de Fátima Salvini, Gustavo Orione Puntel, Joao Luiz Quagliotti Durigan
OBJECTIVES: To investigate the effects of multiple cryotherapy applications after muscle injury on markers of oxidative stress. METHODS: Following cryolesion-induced skeletal muscle injury in rats, ice was applied at the injured site for 30 minutes, three times per day, on the day of injury, and for 2 days after injury. To determine the effect of the cryotherapy treatment on markers of oxidative stress, biochemical analyses were performed 3, 7, and 14 days after injury...
October 18, 2016: Redox Report: Communications in Free Radical Research
A Tassopoulos, A Chalkias, A Papalois, N Iacovidou, T Xanthos
The intestine is highly sensitive to ischemia/reperfusion (I/R) injury. Intestinal I/R may cause local tissue injury and disruption of the intestinal mucosal barrier, allowing the passage of viable bacteria and endotoxins from the gastrointestinal lumen to distant organs. This phenomenon, known as bacterial translocation (BT), may lead to systemic disorders with high morbidity and mortality. Oxidative stress mediators such as reactive oxygen species, polymorphonuclear neutrophils and nitric oxide are believed to contribute to the intestinal I/R injury...
October 13, 2016: Redox Report: Communications in Free Radical Research
Víctor Molina, Bettina von Dessauer, Ramón Rodrigo, Cristian Carvajal
OBJECTIVES: Oxidative stress is known to participate in the progression of sepsis. Definite data regarding the behavior of oxidative stress biomarkers in pediatric sepsis is still lacking. This study hypothesized that oxidative stress occurs in pediatric sepsis and that the magnitude of the redox derangement is associated with worse clinical progression. METHODS: Forty-two previously healthy pediatric patients with sepsis and a group of control subjects were included...
October 13, 2016: Redox Report: Communications in Free Radical Research
Magdalena Wiecek, Marcin Maciejczyk, Jadwiga Szymura, Malgorzata Kantorowicz, Zbigniew Szygula
OBJECTIVES: The aim of the study was to evaluate the activity of xanthine oxidase (XO) in the blood of men and women during the first hour following a single anaerobic exercise (AN-EX), and after 24 hours of recovery, and to determine whether the changes in XO activity in the blood after AN-EX are dependent on anaerobic performance. METHODS: Ten men and ten women performed a single AN-EX. Blood was collected before and five times after completion of the AN-EX. The activity of XO was determined...
October 7, 2016: Redox Report: Communications in Free Radical Research
Zhihui Jiang, Jian Wang, Huiting Xue, Meng Wang, Hai Jiang, Yinku Liang, Alberto C Dias, Marslin Gregory, Chen Chen, Xiaoying Zhang
BACKGROUND: In Chinese folk medicine, Corni fructus (C. fructus) has traditionally been used to improve liver function, although the mechanism underlying its activity remains unclear. The aim of the present study was to evaluate the protective effects of wild C. fructus methanolic extract against acute alcoholic liver injury. METHODS: Alcohol was administered to mice for three consecutive days, either alone or in combination with C. fructus methanolic extract (50, 100, or 200 mg/kg body weight/d)...
October 7, 2016: Redox Report: Communications in Free Radical Research
M G Barua, J P Escalada, M Bregliani, A Pajares, S Criado
OBJECTIVES: Catechins are important components of human diet and have received special attention due to their antioxidant capacity. The purpose of this paper was to study the antioxidant action of (+)-catechin (CTQ) in the presence of vitamin B2 (riboflavin) as light-absorbing agent. Furthermore, two model compounds, catechol (CTC) and resorcinol (RSC), were selected in order to elucidate the reactive target of the CTQ molecule. The influence of pH-medium was investigated. METHODS: Stationary photolysis, polarographic detection of dissolved oxygen, reactive oxygen species (ROS)-scavengers, time-resolved near-IR phosphorescence detection, stationary, and time-resolved fluorescence and laser flash photolysis techniques were employed...
October 6, 2016: Redox Report: Communications in Free Radical Research
Daniela Soto, María Gomez-Serrano, Azul Pieralisi, Juan C Calvo, Belén Peral, Liliana N Guerra
OBJECTIVES: Reports investigating the effects of antioxidants on obesity have provided contradictory results. We have previously demonstrated that treatment with the antioxidant N-acetylcysteine (NAC) inhibits cellular triglyceride (Tg) accumulation as well as total cellular monoamine oxidase A (MAOA) expression in 3T3-L1 mature adipocytes (Calzadilla et al., Redox Rep. 2013;210-218). Here we analyzed the role of NAC on adipogenic differentiation pathway. METHODS: Assays were conducted using 3T3-L1 preadipocytes (undifferentiated cells: CC), which are capable of differentiating into mature adipocytes (differentiated cells: DC)...
September 27, 2016: Redox Report: Communications in Free Radical Research
Reenu Singh Tanwar, Suman Bala Sharma, Krishna Madhava Prabhu
OBJECTIVES: Eugenia jambolana (E. jambolana) is well known for its antidiabetic potential. The aim of the present study was to investigate the antidiabetic and antioxidative effect of an active compound (FIIc) isolated from fruit-pulp of E. jambolana in streptozotocin (45 mg/kg body weight)-induced diabetic rats. METHODS: FIIc was isolated from the crude aqueous extract of fruit-pulp by ion-exchange column chromatography and high-performance column chromatography...
September 21, 2016: Redox Report: Communications in Free Radical Research
Agnieszka Krawczyk, Dariusz Nowak, Piotr Jan Nowak, Gianluca Padula, Sylwia Kwiatkowska
OBJECTIVES: Reactive oxygen species, which are implicated in the process of carcinogenesis, are also responsible for cell death during chemotherapy (CHT). Therefore, the aim of the study was to evaluate exhaled H2O2 levels in non-small cell lung cancer (NSCLC) patients before and after CHT. METHODS: Thirty patients (age 61.3 ± 9.3 years) with advanced NSCLC (stage IIIB-IV) and 15 age-matched healthy cigarette smokers were enrolled into the study. Patients received four cycles of cisplatin or carboplatin with vinorelbine every three weeks...
September 9, 2016: Redox Report: Communications in Free Radical Research
Hélène Talarmin, Frédéric Derbré, Luz Lefeuvre-Orfila, Karelle Léon, Mickaël Droguet, Jean-Pierre Pennec, Marie-Agnès Giroux-Metgès
OBJECTIVES: The aim of this study was to determine whether non-lethal sepsis induced by cecal ligation and puncture (CLP) modulates oxidative damage and enzymatic antioxidant defenses in diaphragm and hindlimb skeletal muscles (soleus and Extensor Digitorus Longus (EDL)). METHODS: Female Wistar rats were divided into four experimental groups: (1) control animals, (2) animals sacrificed 2 hours or (3) 7 days after CLP, and (4) sham-operated animals. At the end of the experimental procedure, EDL, soleus, and diaphragm muscles were harvested and 4-hydroxynonenal (HNE)-protein adducts and protein carbonyl contents were examined in relation to superoxide dismutase and catalase expression and activities...
September 6, 2016: Redox Report: Communications in Free Radical Research
Suhee Kim, Sun Hee Ahn, Hee-Young Yang, Jin-Sil Lee, Hyang-Gi Choi, Young-Kyu Park, Tae-Hoon Lee
OBJECTIVES: In tissue samples from patients with colorectal cancer (CRC), oxidation of C420 and C457 of plakoglobin (Pg) within tumor tissue was identified by proteomic analysis. The aim of this study was to identify the roles of Pg C420 and C457. METHODS: Human CRC tissues, CRC and breast cancer cells, and normal mouse colon were prepared to validate Pg oxidation. MC38 cells were co-transfected with E-cadherin plus wild type (WT) or mutant (C420S or C457S) Pg to evaluate protein interactions and cellular localization, proliferation, and migration...
August 29, 2016: Redox Report: Communications in Free Radical Research
Jun Wang, Gizem Keceli, Rui Cao, Jiangtao Su, Zhiyuan Mi
OBJECTIVES: This review summarizes the spectroscopic results, which will provide useful suggestions for future research. In addition, the fields that urgently need more information are also advised. BACKGROUND: Nitrite-NO-cGMP has been considered as an important signaling pathway of NO in human cells. To date, all the four known human molybdenum-containing enzymes, xanthine oxidase, aldehyde oxidase, sulfite oxidase, and mitochondrial amidoxime-reducing component, have been shown to function as nitrite reductases under hypoxia by biochemical, cellular, or animal studies...
August 9, 2016: Redox Report: Communications in Free Radical Research
Aykan Yucel, Cem Yasar Sanhal, Korkut Daglar, Ozgur Kara, Dilek Uygur, Ozcan Erel
OBJECTIVE: To investigate the presence of oxidative stress (OS) in pregnant women with Familial Mediterranean fever (FMF) in the first trimester by evaluating thiol/disulphide homeostasis. STUDY DESIGN: A total of 31 pregnant women with a diagnosis of FMF, between 11(0) and 13(6) weeks of gestation, were compared with 51 healthy pregnant controls at the same gestational weeks. A recently defined method was used to measure plasma native thiol, total thiol and disulphide levels...
November 2016: Redox Report: Communications in Free Radical Research
Hatice Sezen, Hasan Kandemir, Emin Savik, Sultan Basmacı Kandemir, Fethiye Kilicaslan, Hasan Bilinc, Nurten Aksoy
OBJECTIVES: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD). METHODS: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls). RESULTS: Age and sex were similar between the groups (P > 0...
November 2016: Redox Report: Communications in Free Radical Research
Aysel Vehapoglu, Serdar Turkmen, Nilufer Goknar, Ömer Faruk Özer
OBJECTIVE: There are associations between some inflammatory and oxidative markers and obesity in adults, but whether prepubescent children of different weights also have such markers has not been studied. We investigated multiple inflammatory markers and levels of erythrocyte oxidant/antioxidant enzymes in prepubescent children of different weights. METHODS: Children aged 2-11 years were divided into three groups: 80 were underweight, 90 were obese but otherwise healthy, and 80 were healthy age- and sex-matched children of normal-weight...
November 2016: Redox Report: Communications in Free Radical Research
Dilek Arpaci, Sevim Karakas Celik, Murat Can, Esra Ermiş, Fatih Kuzu, Furuzan Kokturk, Ayse Ceylan Hamamcioglu, Ahmet Dursun, Taner Bayraktaroglu
BACKGROUND: Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly. METHODS: A total of 48 acromegalic patients and 44 healthy controls were included in this study...
November 2016: Redox Report: Communications in Free Radical Research
Volodymyr I Lushchak
OBJECTIVE: We propose some clues for classification of oxidative stresses based on their intensity and time-course. BACKGROUND: Oxidative stress is studied for more than three decades and it is clear that it may differ on the parameters of interest. But up to now there is no any system for formal discrimination between different types of the stress. Such approach can provide important benefits at description of experimental data. METHOD: We briefly review information on oxidative stresses and show that the theoretical concept is actually poorly developed since introduction of the first definition in 1985 by H...
November 2016: Redox Report: Communications in Free Radical Research
Isaac A Adedara, Amos O Abolaji, Blessing E Odion, Abiola A Omoloja, Isioma J Okwudi, Ebenezer O Farombi
OBJECTIVES: Exposure to 2,5-hexanedione (2,5-HD) is well known to be associated with reproductive dysfunctions in both humans and animals. However, the role of oxidative stress in 2,5-HD-induced toxicity in testes and sperm has not yet been studied. METHODOLOGY: The present study investigated the influence of 2,5-HD on antioxidant systems in the testes and epididymal sperm of rats following exposure to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 consecutive days...
November 2016: Redox Report: Communications in Free Radical Research
T P Smina, Jini Joseph, K K Janardhanan
OBJECTIVES: The in vivo radio-protective effect of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst was evaluated using Swiss albino mice, by pre-treatment with total triterpenes for 14 days, followed by a whole body exposure to γ-radiation. METHODS: The activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and the level of reduced glutathione (GSH) were analysed in liver and brain homogenates...
November 2016: Redox Report: Communications in Free Radical Research
Joanna Robaczewska, Kornelia Kędziora-Kornatowska, Robert Kucharski, Maria Nowak, Marta Muszalik, Maciej Kornatowski, Józef Kędziora
BACKGROUND: There is strong evidence that hypertension and depression are comorbid and oxidative stress is implicated in both pathologies. We aimed to elucidate the relationship between biochemical markers of the antioxidant-pro-oxidant equilibrium and depression in hypertension. METHODS: Blood was collected from patients diagnosed with depression, hypertension, or comorbid depression and hypertension and healthy age- and sex-matched controls. Whole blood reduced glutathione, erythrocyte superoxide dismutase (SOD-1), glutathione peroxidase (GPx-1), glutathione reductase (GR), malondialdehyde (MDA), and plasma hydrogen peroxide (H2O2) were assayed using spectrophotometry, and heme oxygenase (HO-1) levels were determined immunoenzymatically...
September 2016: Redox Report: Communications in Free Radical Research
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