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Redox Report: Communications in Free Radical Research

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https://www.readbyqxmd.com/read/28403686/swimming-training-induces-liver-adaptations-to-oxidative-stress-and-insulin-sensitivity-in-rats-submitted-to-high-fat-diet
#1
Aline Cruz Zacarias, Maria Andrea Barbosa, Renata Guerra-Sá, Uberdan Guilherme Mendes De Castro, Frank Silva Bezerra, Wanderson Geraldo de Lima, Leonardo M Cardoso, Robson Augusto Souza Dos Santos, Maria José Campagnole-Santos, Andréia Carvalho Alzamora
Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin...
April 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28393660/plasma-low-molecular-weight-thiol-disulphide-homeostasis-as-an-early-indicator-of-global-and-focal-cerebral-ischaemia
#2
Alexander Vladimirovich Ivanov, Valery Vasil'evich Alexandrin, Alexander Alexandrovich Paltsyn, Ksenya Alexandrovna Nikiforova, Edward Danielevich Virus, Boris Petrovich Luzyanin, Marina Yurievna Maksimova, Mikhail Aleksanrovich Piradov, Aslan Amirkhanovich Kubatiev
OBJECTIVE: Recent studies have shown that cerebral ischaemia causes not only local, but also systemic oxidative stress. This leads to oxidation of thiol-containing compounds, including low-molecular-weight thiols (cysteine, glutathione, homocysteine and others). Therefore, the aim of this work was to verify the hypothesis that the thiol/disulphide homeostasis of low-molecular-weight thiols is disturbed in the early stages of cerebral ischaemia. METHODS: Two experimental rat models of ischaemia were used: a global model of vascular ischaemia (clamping the common carotid arteries + haemorrhage) and focal ischaemia (middle cerebral artery occlusion)...
April 8, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28366046/sodium-arsenite-induced-cardiovascular-and-renal-dysfunction-in-rat-via-oxidative-stress-and-protein-kinase-b-akt-pkb-signaling-pathway
#3
Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Racheal Asenuga, Grace Onyeche Ochigbo, Abiola Olumuyiwa Adejumobi, Adeolu Alex Adedapo, Momoh Audu Yakubu
OBJECTIVES: Arsenic is a ubiquitous element that is widely distributed in the environment to which man and animals are exposed. Cardiovascular disease is one of the aftermaths of chronic arsenic exposure-related morbidity and mortality. This study sought to investigate the possibility of reversal from arsenic-induced cardio-renal toxicity following exposure and subsequent withdrawal. The study also seeks to understand the mechanism of action of this reversal. METHODS: Rats were orally exposed to sodium arsenite at 10, 20 and 40 mg/kg daily for 4 weeks followed by 4 weeks of withdrawal...
April 2, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28320258/sex-differences-in-oxidative-stress-after-eccentric-and-concentric-exercise
#4
Magdalena Wiecek, Marcin Maciejczyk, Jadwiga Szymura, Zbigniew Szygula
OBJECTIVES: Comparison of redox balance changes in the blood of women and men as a result of submaximal eccentric (ECC) and concentric (CONC) efforts. METHODS: 10 women and 10 men performed three 45-minute submaximal treadmill runs at constant velocities (downhill run - ECC, uphill run - CONC and level run). Prior to the 45-minute exercises, after their completion and following 24 hours of recovery, the concentration of lactate, oxidized low-density lipoprotein (ox-LDL), 3-nitrotyrosine, uric acid (UA) and the white blood cell count (WBC), neutrophil (NEUT), lymphocyte (LYMPH) and monocyte content in the blood were determined...
March 20, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28288548/upregulated-glutathione-transferase-omega-1-correlates-with-progression-of-urinary-bladder-carcinoma
#5
Tatjana Djukic, Tatjana Simic, Marija Pljesa-Ercegovac, Marija Matic, Sonja Suvakov, Vesna Coric, Dejan Dragicevic, Ana Savic-Radojevic
OBJECTIVES: Newly discovered glutathione transferase omega 1 (GSTO1-1) plays an important role in the glutathionylation cycle, a significant mechanism of protein function regulation. GSTO1-1 expression pattern has not been studied in transitional cell carcinoma (TCC), as yet. METHODS: A total of 56 TCC tumor and corresponding non-tumor specimens were investigated. Glutathione content and thioltransferase activity were measured spectrophotometrically. Protein-glutathione mixed disulfides were measured fluorimetrically...
March 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28288542/the-role-of-the-saliva-antioxidant-barrier-to-reactive-oxygen-species-with-regard-to-caries-development
#6
A Jurczak, D Kościelniak, A Skalniak, M Papież, P Vyhouskaya, W Krzyściak
OBJECTIVES: The aim of this study was to evaluate the role of the antioxidant barrier in the saliva of children with caries, and its impact on the colonization of cariogenic bacteria. METHODS: This is a cross-sectional study of 81 children aged 1-5 years. Antioxidant levels and salivary bacterial profiles were measured. Patients were divided into two groups as follows: initial stage decay, termed non-cavitated (1-2 in International Caries Detection and Assessment System (ICDAS)), and extensive decay, termed cavitated lesions (5-6 in ICDAS)...
March 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28288539/ischemia-modified-albumin-as-a-marker-of-vascular-dysfunction-and-subclinical-atherosclerosis-in-%C3%AE-thalassemia-major
#7
Amira Abdel Moneam Adly, Nayera Hazaa Khalil ElSherif, Eman Abdel Rahman Ismail, Yosra Abdelzaher Ibrahim, Gamal Niazi, Sara Hamed Elmetwally
BACKGROUND: Ischemia-modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and an independent predictor of major adverse cardiovascular events. OBJECTIVES: To measure the levels of IMA in 45 children and adolescents with β-thalassemia major (β-TM) compared with 30 healthy controls and assess its relation to lipid peroxidation, vascular complications and subclinical atherosclerosis. METHODS: β-TM patients without symptoms of heart disease were studied focusing on transfusion history, chelation therapy, serum ferritin, malondialdehyde (MDA) and IMA levels...
March 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28276289/natural-antioxidants-in-the-treatment-and-prevention-of-diabetic-nephropathy-a-potential-approach-that-warrants-clinical-trials
#8
Noori Al-Waili, Hamza Al-Waili, Thia Al-Waili, Khelod Salom
Diabetic nephropathy is the major cause of end-stage renal disease and effective and new therapeutic approaches are needed in diabetic nephropathy and chronic kidney diseases. Oxidative stress and inflammatory process are important factors contributing to kidney damage by increasing production of oxidants. KEAP1/Nrf2/ARE pathway regulates the transcription of many antioxidant genes and modulation of the pathway up regulates antioxidants. NFB controls the expression of genes involved in the inflammatory response...
March 9, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28249551/gender-dependent-differences-of-mitochondrial-function-and-oxidative-stress-in-rat-skeletal-muscle-at-rest-and-after-exercise-training
#9
Firas Farhat, Aline Amérand, Bernard Simon, Nathalie Guegueniat, Christine Moisan
OBJECTIVE: This study investigated gender-dependent differences of mitochondrial function and sensitivity to in vitro ROS exposure in rat skeletal muscle at rest and after exercise training. METHODS: Wistar rats underwent running training for 6 weeks. In vitro measurements of hydroxyl radical production, oxygen consumption (under basal and maximal respiration conditions) and ATP production were made on permeabilized fibers. Mitochondrial function was examined after exposure and non-exposure to an in vitro generator system of reactive oxygen species (ROS)...
March 1, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28245708/exposure-to-sodium-molybdate-results-in-mild-oxidative-stress-in-drosophila-melanogaster
#10
Natalia V Perkhulyn, Bohdana M Rovenko, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I Lushchak
OBJECTIVES: The study was conducted to assess the redox status of Drosophila flies upon oral intake of insulin-mimetic salt, sodium molybdate (Na2MoO4). METHODS: Oxidative stress parameters and activities of antioxidant and associated enzymes were analyzed in two-day-old D. melanogaster insects after exposure of larvae and newly eclosed adults to three molybdate levels (0.025, 0.5, or 10 mM) in the food. RESULTS: Molybdate increased content of low molecular mass thiols and activities of catalase, superoxide dismutase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase in males...
February 28, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28209094/attenuation-of-arsenic-trioxide-induced-cardiotoxicity-through-flaxseed-oil-in-experimental-rats
#11
Mathews V Varghese, M Abhilash, Manju Alex, M V Sauganth Paul, A Prathapan, K G Raghu, R Harikumaran Nair
OBJECTIVES: Arsenic trioxide (As2O3) is a potent drug for acute promyelocytic leukaemia, but its clinical trials are allied with some serious adverse events mainly cardiac functional abnormalities. So the objective of our investigation is to identify the cardioprotective action of flaxseed oil (FSO), a natural compound against As2O3 induced cardiotoxicity. METHODS: Male wistar rats were treated with As2O3 (4 mg/kg) to induce cardiotoxicity. FSO (250 and 500 mg/kg) was given in combination with As2O3 for evaluating its cardioprotective efficacy...
February 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28209096/increased-oxidative-stress-alters-nucleosides-metabolite-levels-in-sickle-cell-anemia
#12
Lívia Gelain Castilhos, Juliana Sorraila de Oliveira, Stephen Adeniyi Adefegha, Luana Pereira Magni, Pedro Henrique Doleski, Fatima Husein Abdalla, Cínthia Melazzo de Andrade, Daniela Bitencourt Rosa Leal
OBJECTIVES: This study was conducted to assess the markers of oxidative stress, myeloperoxidase (MPO), acetylcholinesterase (AChE) and xanthine oxidase (XO) activities as well as the levels of nucleotide metabolites in sickle cell anemia (SCA) patients. METHODS: Fifteen SCA treated patients and 30 health subjects (control group) were selected. The markers of oxidative stress (levels of reactive oxygen species (ROS), plasma proteins, carbonyl content, lipid peroxidation (TBARS), total thiols (T-SH), glutathione and catalase activity), MPO, AChE and XO activities as well as the levels of nucleotide metabolites were measured in SCA patients...
February 16, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28277068/vitamin-c-and-trolox-decrease-oxidative-stress-and-hemolysis-in-cold-stored-human-red-blood-cells
#13
Kamila Czubak, Adam Antosik, Natalia Cichon, Halina Malgorzata Zbikowska
OBJECTIVES: To investigate the effects of sodium ascorbate (SA) (5-3125 μM) and a combination of SA and Trolox (25 and 125 μM) on oxidative changes generated in red blood cells (RBCs) followed by up to 20 days refrigerated storage. METHODS: RBCs were isolated from CPD-preserved human blood. Percentage of hemolysis and extracellular activity of lactate dehydrogenase (LDH) were measured to assess the RBC membrane integrity. Lipid peroxidation (LPO), glutathione (GSH) and total antioxidant capacity (TAC) were quantified by thiobarbituric acid-reactive substances, Ellman's reagent and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonate) [Formula: see text]-based assay, respectively...
February 11, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28075321/effects-of-exercise-and-lifestyle-intervention-on-oxidative-stress-in-chronic-kidney-disease
#14
David M Small, Kassia S Beetham, Erin J Howden, David R Briskey, David W Johnson, Nicole M Isbel, Glenda C Gobe, Jeff S Coombes
OBJECTIVES: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. METHODS: A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months...
May 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27884085/the-roles-of-myeloperoxidase-in-coronary-artery-disease-and-its-potential-implication-in-plaque-rupture
#15
Nathaniel Teng, Ghassan J Maghzal, Jihan Talib, Imran Rashid, Antony K Lau, Roland Stocker
Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque...
March 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27366872/erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27077454/intravenous-rutin-in-rat-exacerbates-isoprenaline-induced-cardiotoxicity-likely-due-to-intracellular-oxidative-stress
#17
Tomáš Filipský, Michal Říha, Pavlína Hašková, Veronika Pilařová, Lucie Nováková, Vladimír Semecký, Jaroslava Vávrová, Magdaléna Holečková, Vladimir Palicka, Tomáš Šimůnek, Radomír Hrdina, Přemysl Mladěnka
OBJECTIVES: Rutin, quercetin-3-O-rutinoside, a natural flavonol glycoside, has shown various in vitro benefits with potential use treating human diseases, especially cardiovascular system disorders. Antioxidant properties are assumed to underlie the majority of these benefits. Yet rutin pro-oxidant properties have been reported as well. Our research group has recently shown aggravating effects on isoprenaline (ISO)-induced cardiotoxicity in Wistar:Han rats after 24 hours. METHODS: This study was designed to examine in more detail the reasons for the negative effects of rutin (11...
March 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27075937/nitrite-and-nitroso-compounds-can-serve-as-specific-catalase-inhibitors
#18
Vladimir Yu Titov, Anatoly N Osipov
OBJECTIVE: We present evidence that nitrite and nitrosothiols, nitrosoamines and non-heme dinitrosyl iron complexes can reversibly inhibit catalase with equal effectiveness. METHODS: Catalase activity was evaluated by the permanganatometric and calorimetric assays. RESULTS: This inhibition is not the result of chemical transformations of these compounds to a single inhibitor, as well as it is not the result of NO release from these substances (as NO traps have no effect on the extent of inhibition)...
March 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/26870880/the-relationships-among-the-levels-of-oxidative-and-antioxidative-parameters-fev1-and-prolidase-activity-in-copd
#19
Selami Ekin, Ahmet Arısoy, Hulya Gunbatar, Bunyamin Sertogullarindan, Aysel Sunnetcioglu, Hatice Sezen, Selvi Asker, Hanifi Yıldız
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by poorly reversible airflow limitations associated with an abnormal inflammatory response of the lung. METHODS: We investigated whether prolidase levels in serum, total antioxidant status, total oxidative status (TOS), and the oxidative stress index (OSI) were associated with the etiopathogenesis of COPD, and whether there is a relationship between prolidase activity and oxidative parameters and carotid artery intima-media thickness (CIMT) in patients with COPD...
March 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28073324/3-methoxy-aroylhydrazones-free-radicals-scavenging-anticancer-and-cytoprotective-potency
#20
Nadya Hristova-Avakumova, Krassimira Yoncheva, Boryana Nikolova-Mladenova, Trayko Traykov, Georgi Momekov, Vera Hadjimitova
OBJECTIVE: This study aimed to determine the capability of newly designed 3-methoxy derivatives of salicylaldehyde benzoylhydrazone to influence the oxidative stress processes and to test their in vitro cytotoxicity. METHODS: We have used chemiluminescent and spectrophotometric model systems containing different types of reactive oxygen species (OH(●), OCl(─) and O2(─●)). The hydrazones effect on the viability of Hep-G2, HEK-293 and SH-SY5Y cell lines was determined via MTT assay...
January 10, 2017: Redox Report: Communications in Free Radical Research
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