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Redox Report: Communications in Free Radical Research

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https://www.readbyqxmd.com/read/28812524/biologically-important-hydrazide-containing-fused-azaisocytosines-as-antioxidant-agents
#1
Małgorzata Sztanke, Krzysztof Sztanke
OBJECTIVES: Two important classes of hydrazide-containing fused azaisocytosines were evaluated as possible antioxidants and characterised by UV spectroscopy. METHODS: 2,2-Diphenyl-1-picrylhydazyl (DPPH), nitric oxide (NO), hydrogen peroxide (H2O2) scavenging potencies and reducing power of molecules were evaluated. RESULTS: The strongest DPPH scavengers were found to be 9, showing the potency superior to that of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) and comparable to that of ascorbic acid (AA), and 6, revealing the antioxidant potency superior to that of BHA, BHT, PG and Trolox...
August 16, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28657497/hesperidin-attenuates-inflammation-and-oxidative-damage-in-pleural-exudates-and-liver-of-rat-model-of-pleurisy
#2
Stephen Adeniyi Adefegha, Daniela Bitencourt Rosa Leal, Ayodeji Augustine Olabiyi, Ganiyu Oboh, Livia Gelain Castilhos
OBJECTIVES: This study investigated the potential anti-inflammatory effect of hesperidin against carrageenan induced pleurisy in rat model. METHODS: Twenty-four adult female Wistar rats (350 - 450g) were grouped as follows: Group I: rats were administered saline solution only (Normal control group); Group II: rats were administered saline solution (NaCl 0.9%) orally and injected with carrageenan (Inflammation control group); Group III: rats were administered hesperidin only (Hesperidin group); Group IV: rats were administered hesperidin orally and intrapleurally injected with 2% carrageenan (Inflammation treated with hesperidin group)...
June 28, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28651456/phytochemical-treatments-target-kynurenine-pathway-induced-oxidative-stress
#3
K Parasram
OBJECTIVE: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders. METHODS: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson's disease. RESULTS: In these models, phytochemicals have been shown to reduce striatal lesion size, reduce inflammation and prevent lipid peroxidation caused by quinolinic acid...
June 26, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28532341/pterostilbene-protects-against-uvb-induced-photo-damage-through-a-phosphatidylinositol-3-kinase-dependent-nrf2-are-pathway-in-human-keratinocytes
#4
Huaping Li, Na Jiang, Bihua Liang, Qing Liu, Erting Zhang, Liqian Peng, Huiyan Deng, Runxiang Li, Zhenjie Li, Huilan Zhu
OBJECTIVE: Ultraviolet B (UVB) irradiation is the initial etiological factor for various skin disorders, including erythema, sunburn, photoaging, and photocarcinogenesis. Pterostilbene (Pter) displayed remarkable antioxidant, anti-inflammatory, and anticarcinogenic activities. This study aimed to investigate the effective mechanism of Pter against UVB-induced photodamage in immortalized human keratinocytes. METHODS: Human keratinocytes were pretreated with Pter (5 and 10 μM) for 24 h prior to UVB irradiation (300 mJ/cm(2))...
May 22, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27595775/the-diaphragm-is-better-protected-from-oxidative-stress-than-hindlimb-skeletal-muscle-during-clp-induced-sepsis
#5
Hélène Talarmin, Frédéric Derbré, Luz Lefeuvre-Orfila, Karelle Léon, Mickaël Droguet, Jean-Pierre Pennec, Marie-Agnès Giroux-Metgès
OBJECTIVES: The aim of this study was to determine whether non-lethal sepsis induced by cecal ligation and puncture (CLP) modulates oxidative damage and enzymatic antioxidant defenses in diaphragm and hindlimb skeletal muscles (soleus and Extensor Digitorus Longus (EDL)). METHODS: Female Wistar rats were divided into four experimental groups: (1) control animals, (2) animals sacrificed 2 hours or (3) 7 days after CLP, and (4) sham-operated animals. At the end of the experimental procedure, EDL, soleus, and diaphragm muscles were harvested and 4-hydroxynonenal (HNE)-protein adducts and protein carbonyl contents were examined in relation to superoxide dismutase and catalase expression and activities...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27387094/oxidative-stress-in-otosclerosis
#6
Elif Baysal, Secaattin Gulsen, Ismail Aytac, Fatih Celenk, Nuray Ensari, Seyithan Taysi, Habib Binici, Cengiz Durucu, Semih Mumbuc, Muzaffer Kanlikama
OBJECTIVES: Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear. METHODS: This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosis patients and healthy subjects with respect to oxidative stress...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27320745/serum-prolidase-activity-and-oxidative-antioxidative-status-in-patients-with-developmental-dysplasia-of-the-hip-and-its-relationship-with-radiographic-severity
#7
Mehmet Akif Altay, Cemil Ertürk, Ali Levent, Baki Volkan Çetin, Nurten Aksoy
BACKGROUND: We aimed to investigate serum prolidase activity and to investigate its association with oxidative-antioxidative status in patients with developmental dysplasia of the hip (DDH). METHODS: Oxidative status parameters, including lipid hydroperoxide (LOOH), total oxidant status (TOS), and the oxidative stress index (OSI), and antioxidative status parameters, free sulfhydryl groups (Total -SH), and total antioxidative capacity (TAC), as well as serum prolidase activity were assessed in patients with DDH (n = 93), and in healthy controls (n = 82)...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27198857/arteriovenous-oscillations-of-the-redox-potential-is-the-redox-state-influencing-blood-flow
#8
Jaroslaw Poznanski, Pawel Szczesny, Bartosz Pawlinski, Tomasz Mazurek, Piotr Zielenkiewicz, Zdzislaw Gajewski, Leszek Paczek
OBJECTIVE: Studies on the regulation of human blood flow revealed several modes of oscillations with frequencies ranging from 0.005 to 1 Hz. Several mechanisms were proposed that might influence these oscillations, such as the activity of vascular endothelium, the neurogenic activity of vessel wall, the intrinsic activity of vascular smooth muscle, respiration, and heartbeat. These studies relied typically on non-invasive techniques, for example, laser Doppler flowmetry. Oscillations of biochemical markers were rarely coupled to blood flow...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27096391/alteration-of-thiol-disulphide-homeostasis-in-acute-tonsillopharyngitis
#9
Soner Sertan Kara, Ozcan Erel, Tugba Bedir Demirdag, Burcu Ceylan Cura Yayla, Belgin Gulhan, Salim Neselioglu, Meltem Polat, Gokhan Kalkan, Anil Tapisiz, Hasan Tezer
OBJECTIVE: Thiol-disulphide homeostasis (TDH) has a critical role in various clinical disorders. We aimed to assess the association of TDH with acute tonsillopharyngitis (AT) in children. METHODS: This study included 94 (73 viral and 21 bacterial) tonsillopharyngitis patients and 88 control children. Their native thiol, total thiol, and disulphide levels were measured. RESULTS: Viral and bacterial tonsillopharyngitis patients had lower native thiol levels compared with healthy children (P < 0...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27090392/oxidative-stress-is-associated-with-decreased-heart-rate-variability-in-patients-with-chronic-kidney-disease
#10
Shannon B Fadaee, Kassia S Beetham, Erin J Howden, Tony Stanton, Nicole M Isbel, Jeff S Coombes
OBJECTIVES: Elevated oxidative stress and reduced heart rate variability (HRV) is prevalent in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Previous studies have identified a positive association between elevated oxidative stress and autonomic dysfunction, however this relationship has not yet been investigated in the CKD population. METHODS: Plasma was collected from 78 patients with stage 3-4 CKD (estimated glomerular filtration rate 25-60 ml/min/1...
September 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28521618/markers-of-oxidative-nitrative-damage-of-plasma-proteins-correlated-with-edss-and-bdi-scores-in-patients-with-secondary-progressive-multiple-sclerosis
#11
Agnieszka Morel, Michał Bijak, Marta Niwald, Elżbieta Miller, Joanna Saluk
Objectives The objective of the present study was to evaluate oxidative/nitrative stress in the plasma of 50 patients suffering from the secondary progressive course of multiple sclerosis (MS), and to verify its correlation with physical and mental disability as assessed by the Expanded Disability Status Scale (EDSS), and the Beck Depression Inventory (BDI). Methods Oxidative and nitrative damage to proteins was determined by the level of carbonyl groups and 3-nitrotyrosine using ELISA test. Based on the reaction with Ellman's reagent, we estimated the concentration of oxidized thiol groups...
May 19, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28514939/antioxidant-properties-of-drugs-used-in-type-2-diabetes-management-could-they-contribute-to-confound-or-conceal-effects-of-antioxidant-therapy
#12
Siu Wai Choi, Cyrus K Ho
OBJECTIVES: This is a narrative review, investigating the antioxidant properties of drugs used in the management of diabetes, and discusses whether these antioxidant effects contribute to, confound, or conceal the effects of antioxidant therapy. METHODS: A systematic search for articles reporting trials, or observational studies on the antioxidant effect of drugs used in the treatment of diabetes in humans or animals was performed using Web of Science, PubMed, and Ovid...
May 17, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28498788/nutritional-status-energy-expenditure-and-protein-oxidative-stress-after-kidney-transplantation
#13
Larissa Vieira Marino, Elen Almeida Romão, Paula Garcia Chiarello
OBJECTIVES: To evaluate the association between nutritional status, resting energy expenditure (REE), and protein oxidative stress in patients after kidney transplantation (KT). METHODOLOGY: The study evaluated 35 patients transplanted at the time of hospital discharge and 3 months after regarding: body composition, REE (by indirect calorimetry), and injury factor (IF); serum urea, creatinine, glucose, albumin, total protein, advanced oxidation protein products (AOPP), vitamin C...
May 12, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28482759/caffeine-prevents-high-intensity-exercise-induced-increase-in-enzymatic-antioxidant-and-na-k-atpase-activities-and-reduction-of-anxiolytic-like-behaviour-in-rats
#14
Juliano M Vieira, Fabiano B Carvalho, Jessié M Gutierres, Mayara S P Soares, Pathise S Oliveira, Maribel A Rubin, Vera M Morsch, Maria Rosa Schetinger, Roselia M Spanevello
OBJECTIVE: Here we investigated the impact of chronic high-intensity interval training (HIIT) and caffeine consumption on the activities of Na(+)-K(+)-ATPase and enzymes of the antioxidant system, as well as anxiolytic-like behaviour in the rat brain. METHODS: Animals were divided into groups: control, caffeine (4 mg/kg), caffeine (8 mg/kg), HIIT, HIIT plus caffeine (4 mg/kg) and HIIT plus caffeine (8 mg/kg). Rats were trained three times per week for 6 weeks, and caffeine was administered 30 minutes before training...
May 8, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28475470/betulinic-acid-protects-against-n-nitrosodimethylamine-induced-redox-imbalance-in-testes-of-rats
#15
Gbadebo E Adeleke, Oluwatosin A Adaramoye
OBJECTIVES: N-nitrosodimethylamine (NDMA) is known to elicit carcinogenic activity in the liver and kidney of animals. There is a dearth of information of its effect in testis. This study evaluated the protective role of betulinic acid (BA) against NDMA-induced redox imbalance in testes of rats. METHODOLOGY: Twenty-four male rats were assigned into four groups and treated with normal saline, BA, NDMA and [BA+NDMA]. BA (25 mg/kg) was given for 14 days, while NDMA (5 mg/kg) was given on days 7 and 12...
May 5, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28276289/natural-antioxidants-in-the-treatment-and-prevention-of-diabetic-nephropathy-a-potential-approach-that-warrants-clinical-trials
#16
REVIEW
Noori Al-Waili, Hamza Al-Waili, Thia Al-Waili, Khelod Salom
Diabetic nephropathy is the major cause of end-stage renal disease and effective and new therapeutic approaches are needed in diabetic nephropathy and chronic kidney diseases. Oxidative stress and inflammatory process are important factors contributing to kidney damage by increasing production of oxidants. KEAP1/Nrf2/ARE pathway regulates the transcription of many antioxidant genes and modulation of the pathway up regulates antioxidants. NFB controls the expression of genes involved in the inflammatory response...
May 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28245708/exposure-to-sodium-molybdate-results-in-mild-oxidative-stress-in-drosophila-melanogaster
#17
Natalia V Perkhulyn, Bohdana M Rovenko, Oleh V Lushchak, Janet M Storey, Kenneth B Storey, Volodymyr I Lushchak
OBJECTIVES: The study was conducted to assess the redox status of Drosophila flies upon oral intake of insulin-mimetic salt, sodium molybdate (Na2MoO4). METHODS: Oxidative stress parameters and activities of antioxidant and associated enzymes were analyzed in two-day-old D. melanogaster insects after exposure of larvae and newly eclosed adults to three molybdate levels (0.025, 0.5, or 10 mM) in the food. RESULTS: Molybdate increased content of low molecular mass thiols and activities of catalase, superoxide dismutase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase in males...
May 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28075321/effects-of-exercise-and-lifestyle-intervention-on-oxidative-stress-in-chronic-kidney-disease
#18
COMPARATIVE STUDY
David M Small, Kassia S Beetham, Erin J Howden, David R Briskey, David W Johnson, Nicole M Isbel, Glenda C Gobe, Jeff S Coombes
OBJECTIVES: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. METHODS: A total of 136 stage 3-4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months...
May 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27320473/parameters-of-oxidative-stress-in-saliva-from-patients-with-aggressive-and-chronic-periodontitis
#19
COMPARATIVE STUDY
Andrea B Acquier, Alejandra K De Couto Pita, Lucila Busch, Gabriel A Sánchez
OBJECTIVES: Free radicals play an important role in the onset and progression of many diseases. The aim of this study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) and chronic (CP) periodontitis and its relation with the clinical periodontal status. METHODS: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP with their 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth (PPD), and bleeding on probing (BOP)...
May 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28403686/swimming-training-induces-liver-adaptations-to-oxidative-stress-and-insulin-sensitivity-in-rats-submitted-to-high-fat-diet
#20
Aline Cruz Zacarias, Maria Andrea Barbosa, Renata Guerra-Sá, Uberdan Guilherme Mendes De Castro, Frank Silva Bezerra, Wanderson Geraldo de Lima, Leonardo M Cardoso, Robson Augusto Souza Dos Santos, Maria José Campagnole-Santos, Andréia Carvalho Alzamora
Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin...
April 13, 2017: Redox Report: Communications in Free Radical Research
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