journal
Journals Journal of Ocular Pharmacology...

Journal of Ocular Pharmacology and Therapeutics

https://read.qxmd.com/read/38527183/topical-insulin-for-ocular-surface-disease
#1
JOURNAL ARTICLE
Pau Cid-Bertomeu, Magí Vilaltella, Mireia Martínez, Marta Mir, Valentín Huerva
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a crucial role in the growth, differentiation, and proliferation of corneal epithelial cells, as well as in wound healing processes in various tissues. Purpose: This review explores the potential role of topical insulin in the treatment of ocular surface diseases. Specifically, it examines its impact on corneal nerve regeneration, sub-basal plexus corneal nerves, and its application in conditions like corneal epithelial defects, dry eye disease, and diabetic keratopathy...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38517736/inhibition-of-connective-tissue-growth-factor-expression-in-adult-retinal-pigment-epithelial-19-cells-by-blocking-yes-associated-protein-transcriptional-coactivator-with-pdz-binding-motif-activity
#2
JOURNAL ARTICLE
Yoko Murakami, Toshiyasu Imaizumi, Kouhei Hashizume, Yu Tezuka, Yusuke Oku, Naoyuki Nishiya, Atsushi Sanbe, Daijiro Kurosaka
Purpose: To investigate the effect of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) on connective tissue growth factor (CTGF) expression in adult retinal pigment epithelial (ARPE)-19 cells. We also studied the inhibitory effect of K-975, a new pan-transcriptional enhanced associate domain (TEAD) inhibitor, and luteolin, a plant-derived flavonoid on CTGF expression. Methods: ARPE-19 cells were transfected with either YAP or TAZ overexpression plasmid or treated with transforming growth factor (TGF)-β2 ...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38502814/eyes-on-new-product-development
#3
JOURNAL ARTICLE
Gary D Novack
No abstract text is available yet for this article.
March 19, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38502813/differential-effects-of-benzalkonium-chloride-on-human-trabecular-meshwork-cells-not-treated-or-treated-with-transforming-growth-factor-%C3%AE-2-or-dexamethasone
#4
JOURNAL ARTICLE
Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Nami Nishikiori, Megumi Higashide, Masato Furuhashi, Hiroshi Ohguro
Purpose: The objective of the present study was to evaluate the effects of low concentrations of benzalkonium chloride (BAC) (10-7 %, 10-6 %, or 10-5 %) on healthy and glaucomatous human trabecular meshwork (HTM) cells. For this purpose, we used in vitro models replicating a healthy HTM and HTM with primary open-angle glaucoma (POAG) or steroid-induced glaucoma (SG) using two-dimensional (2D) cultures of HTM cells not treated or treated with a 5 ng/mL solution of transforming growth factor-β2 or 250 nM dexamethasone (DEX)...
March 19, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38451533/relationship-between-conjunctival-corynebacterium-and-5-sheep-blood-agar
#5
LETTER
Omer Faruk Yilmaz, Abdurrahman Sarmis
No abstract text is available yet for this article.
March 6, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38451532/steroid-antivascular-endothelial-growth-factor-combination-therapy-for-neovascular-age-related-macular-degeneration
#6
JOURNAL ARTICLE
Michael Colucciello
No abstract text is available yet for this article.
March 6, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38394222/novel-drug-delivery-systems-for-the-management-of-fungal-keratitis
#7
JOURNAL ARTICLE
Mengyu Ruan, Ruiqing Wang, Yuxi He
Fungal keratitis (FK) is a dangerous corneal infection that is common in tropical and subtropical areas. Its incidence is extremely high, and ocular trauma and contact lenses can lead to FK, but its common treatment such as using topical antifungal eye drop instillation is often less effective because of several drawbacks of the drugs typically used, including limited ocular penetration, high frequency of dosing, poor biocompatibility, and the potential for severe drug reactions. Therefore, the development of novel drug delivery devices for the treatment of FK is urgent...
February 23, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38386983/elevated-kdm4d-expression-in-pterygium-impact-and-potential-inhibition-by-lycium-barbarum-polysaccharide
#8
JOURNAL ARTICLE
Juan Gao, Yuchuan Wang, Ruifang Han, Jun Li, Peng Hao, Jing Li, Xi Chen, Li Jiang, Liming Wang, Yunqing Ma, Luxia Chen, Xuan Li
Purpose: This study aimed to explore the effects of elevated KDM4D expression and potential therapeutic effects of Lycium barbarum polysaccharide (LBP) on pterygium. Methods: The expression levels of KDM4D in the primary pterygium ( n  = 29) and normal conjunctiva ( n  = 14) were detected by immunohistochemistry. The effects of KDM4D on pterygium fibroblasts were detected by the CCK-8 assay, liquid chromatography-mass spectrometry assay, flow cytometry, and scratch wound healing assay...
February 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38252789/dissociation-kinetics-and-antimicrobial-activity-of-ofloxacin-antibiotic-in-artificial-tears-via-1-h-nmr-raman-and-uv-vis-spectroscopic-analysis
#9
JOURNAL ARTICLE
Ahmad Telfah, M-Ali Al-Akhras, Haya AlShheamat, Marwan S Mousa, Inshad Jum'h, Abdel Qader Albawab, Elen Tolstik, Johann Dierks, Roland Hergenröder
Introduction: The hydrogen-bonded networks play a significant role in influencing several physicochemical properties of ofloxacin in artificial tears (ATs), including density, pH, viscosity, and self-diffusion coefficients. The activities of the ofloxacin antibiotic with Ats mixtures are not solely determined by their concentration but are also influenced by the strength of the hydrogen bonding network which highlight the importance of considering factors such as excessive tear production and dry eye conditions when formulating appropriate dosages of ofloxacin antibiotics for eye drops...
January 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38206649/antibiotic-prescribing-patterns-among-u-s-ophthalmologists-and-optometrists-from-2018-to-2021-in-the-medicare-part-d-database
#10
JOURNAL ARTICLE
Elyssa Dionne, Jane Z Spadaro, Agata M P Atayde, Ninani Kombo
Purpose: To assess antibiotic prescribing patterns among ophthalmologists and optometrists from 2018 to 2021. Methods: This is an observational, retrospective cohort study of the Medicare Part D prescriber public use files from 2018 to 2020. Prescription trends were analyzed with analysis of variance and negative binomial regression tests based on specialty, region, and types of antibiotics. Results: From 2018 to 2021, the number of ophthalmologists in the Medicare Part D database decreased from 18,452 to 18,285, and the number of optometrists increased from 23,071 to 24,734...
January 10, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38190319/eyes-on-new-product-development
#11
JOURNAL ARTICLE
Gary D Novack
No abstract text is available yet for this article.
January 8, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38489060/impact-of-prolonged-persisting-subretinal-fluid-on-the-outcome-of-aflibercept-treatment-in-neovascular-age-related-macular-degeneration
#12
JOURNAL ARTICLE
Ji Hyun Lee, Jae Hui Kim
Purpose: To evaluate the effect of prolonged residual subretinal fluid (SRF) on the outcomes of aflibercept treatment in neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). Methods: This retrospective study included patients diagnosed with neovascular AMD or PCV who presented with fovea-involving residual SRF that persisted for a minimum of 6 months while undergoing aflibercept treatment. Changes in best-corrected visual acuity (BCVA) during persistent SRF were evaluated...
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38489059/sustained-delivery-of-olopatadine-from-vitamin-e-loaded-contact-lenses
#13
JOURNAL ARTICLE
Inês M Reis, Philip J Dixon, Poorvajan Sekar, Anuj Chauhan
Purpose: Topical antihistamines, such as olopatadine hydrochloride, an H1 receptor antagonist, are commonly prescribed for treating allergic conjunctivitis. Drug delivery via eye drops has many deficiencies including a short residence time due to tear drainage via the nasolacrimal duct, which results in a low bioavailability and potential for side effects. These deficiencies could be mitigated by a drug-eluting contact lens such as the recently approved ACUVUE® THERAVISION™ WITH KETOTIFEN which is a daily disposable etafilcon, a drug-eluting contact lens with ketotifen (19 μg per lens)...
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38489058/eyes-on-new-product-development
#14
JOURNAL ARTICLE
Gary D Novack
No abstract text is available yet for this article.
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38489057/chloroprocaine-3-gel-as-a-novel-ocular-topical-anesthetic-results-from-a-multicenter-randomized-clinical-trial-in-patients-undergoing-cataract-surgery
#15
JOURNAL ARTICLE
Michele Figus, Fabrizio Giansanti, Edoardo Villani, Jorge L Alió, Ladislav Jančo, Stefano Mercuri, Stefano Camnasio, Carlo Cagini
Purpose: To compare the efficacy and safety of a novel ophthalmic anesthetic, chloroprocaine 3% gel to tetracaine 0.5% eye drops in patients undergoing cataract surgery with phacoemulsification. Methods: This was a prospective, randomized, multicenter, active-controlled, masked-observer, parallel group competitive equivalence study. The study comprised 338 patients having routine cataract extraction by clear corneal phacoemulsification, randomized to receive 3 drops of chloroprocaine gel ( n  = 166) or tetracaine eye drops ( n  = 172) before surgery...
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38346287/the-therapeutic-role-and-mechanism-of-glabridin-under-aspergillus-fumigatus-infection
#16
JOURNAL ARTICLE
Lu Zhan, Xue Tian, Jing Lin, Yingxue Zhang, Guiqiu Zhao, Xudong Peng
Purpose: To characterize the efficiency of glabridin alone and in combination with clinical antifungals in Aspergillus fumigatus keratitis. Methods: The broth microdilution method was performed to investigate whether glabridin exerted an antifungal role on planktonic cells and immature and mature biofilm. Antifungal mechanism was evaluated by Sorbitol and Ergosterol Assays. The synergistic effect of glabridin and antifungals was assessed through the checkerboard microdilution method and time-killing test. Regarding anti-inflammatory role, inflammatory substances induced by A...
2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38150537/vitamin-b-3-supplementation-for-optic-neuropathies-a-comprehensive-review
#17
JOURNAL ARTICLE
Júlio Almeida, Tomás R Costa, Maria Vivas, Catarina Monteiro, Fernando T Vaz, Quirina Ferreira, Isabel Prieto, Luís A Pinto, Joana T Ferreira
Optic neuropathies, such as glaucoma, are some of the leading causes of irreversible blindness worldwide. There has been a lot of research for potential therapies that could attenuate and even reduce the impact of the pathological pathways that lead to the loss of retinal ganglion cells (RGCs). In recent years, vitamin B3 (nicotinamide) has gained some interest as a viable option for these neurodegenerative diseases due to its fundamental role in enhancing the mitochondria metabolism of the RGCs. This review focuses on elucidating the impact of vitamin B3 on retinal cells, especially when in a dysfunctional state like what happens in optic neuropathies, especially glaucoma...
December 27, 2023: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38150534/epinastine-cream-a-novel-once-daily-therapeutic-agent-for-allergic-conjunctivitis
#18
JOURNAL ARTICLE
Naoki Ogura, Koushi Fujisawa, Masatomo Kato
Purpose: To investigate the in vivo efficacy of epinastine cream in type I allergic models. Methods: The dose, timing, and antiallergic effect of epinastine cream on the conjunctiva were evaluated postapplication to the eyelid skin of guinea pigs with histamine- or ovalbumin-induced allergic conjunctivitis. Additionally, we assessed its antiallergic effects on the skin postapplication to the dorsal skin of guinea pigs with ovalbumin-induced passive cutaneous anaphylaxis. Efficacy was estimated by determining the amount of dye that leaked from conjunctival or dorsal skin tissue vessels as a measure of vascular permeability, scoring the severity of allergic symptoms, and observing the scratching behaviors using clinical parameters...
December 27, 2023: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38117668/improved-topical-ophthalmic-natamycin-suspension-for-the-treatment-of-fungal-keratitis
#19
JOURNAL ARTICLE
Chuntian Cai, Ahmed Adel Ali Youssef, Poorva H Joshi, Corinne Varner, Narendar Dudhipala, Soumyajit Majumdar
Purpose: Natamycin (NT) is used as a first-line antifungal prescription in the treatment of fungal keratitis (FK) and is commercially available as a 5% w/v ophthalmic suspension. NT shows poor water solubility and light sensitivity. Thus, the present investigation is aimed to enhance the fraction of NT in solution in the commercial formulation by adding cyclodextrins (CDs), thereby improving the delivery of the drug into deeper ocular tissues. Methods: The solubility of NT in different CDs, the impact of ultraviolet (UV) light exposure, stability at 4°C and 25°C, in vitro release, and ex vivo transcorneal permeation studies were performed...
December 20, 2023: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38117666/intravitreal-dexamethasone-as-a-rescue-for-anti-vascular-endothelial-growth-factor-therapy-in-neovascular-age-related-macular-degeneration-with-persistent-disease-activity-and-high-treatment-demand
#20
JOURNAL ARTICLE
Marlena Pietzuch, Irmela Mantel, Aude Ambresin, Christoph Tappeiner, Dana Nagyova, Guy Donati, Isabel B Pfister, Christin Schild, Justus G Garweg
Purpose: To assess the impact of switching to, or adding, an intravitreal dexamethasone implant (Dex; Ozurdex® ) in anti-vascular endothelial growth factor (VEGF) therapy on disease stability and treatment intervals in eyes with neovascular age-related macular degeneration (nAMD) and persistent disease activity and high treatment demand. Methods: This retrospective noncomparative multicenter longitudinal case series included pseudophakic eyes with nAMD and persistent retinal fluid despite regular anti-VEGF therapy (ranibizumab or aflibercept) that received at least 1 intravitreal Dex implant...
December 20, 2023: Journal of Ocular Pharmacology and Therapeutics
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