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Journal of Ocular Pharmacology and Therapeutics

Bin-Wu Lin, Wei-Lan Huang, Lu Wang, Zi-Man Chen
PURPOSE: To compare the effects of FK-506, cyclosporin A (CsA), and sodium hyaluronate (HA) eye drops for the treatment of botulinum toxin B (BTX-B)-induced mouse dry eye. METHODS: CBA/J mice were randomized into 5 groups. The groups received treatment with eye drops containing 0.025% FK-506 combined with 0.3% HA (FK-506+HA group), 0.025% FK-506 (FK-506 group), 0.05% CsA (CsA group), 0.3% HA (HA group), or 0.9% saline (saline group) 3 days after an intralacrimal gland injection with 20 mU of BTX-B...
September 18, 2018: Journal of Ocular Pharmacology and Therapeutics
Koji Toriyama, Takashi Suzuki, Atsushi Shiraishi
PURPOSE: The aim of this study was to analyze patient backgrounds, including activities of daily living (ADL) and living status, predisposing risk factors, causative agents, and severity with infectious keratitis in old (75 < 85 years of age) and very old (≥85 years of age) patients. METHODS: We retrospectively reviewed 54 old patients who were hospitalized for infectious keratitis. The focus occupancy ratio (FOR) was defined as the total focus area/entire cornea area...
September 15, 2018: Journal of Ocular Pharmacology and Therapeutics
Chang Ho Yoon, Jong Woo Park, Jin Suk Ryu, Mee Kum Kim, Joo Youn Oh
PURPOSE: To investigate the effect of tacrolimus ointment on corneal epithelium. METHODS: Eight-week-old male BALB/c mice were divided into 3 groups. In group 1, no injury was made. In group 2, the central 2-mm corneal epithelium was scraped off. In group 3, the whole corneal and limbal epithelium was removed after absolute ethanol application. In each group, the corneas were observed and treated daily with 0.03% or 0.1% tacrolimus ointment (Protopic® ). The viability of cultivated human corneal epithelial cells was also examined after 24-h incubation with various concentrations of tacrolimus...
September 15, 2018: Journal of Ocular Pharmacology and Therapeutics
Marija Bozic, Milenko Stojkovic, Miroslav Knezevic, Ivan Marjanovic, Anica Bobic-Radovanovic
PURPOSE: To test the hypothesis that the use of refrigerated fixed combination of dorzolamide 2% plus timolol 0.5% solution (COSOPT® ) is associated with less ocular discomfort compared with the use of this solution kept at room temperature. METHODS: In this prospective comparative study, 30 primary open-angle patients and 30 healthy subjects filled in the questionnaire on symptoms (Ocular Surface Disease Index) and subjective stinging feeling scale (1-10), at the start of study and 30 days after continuous use of refrigerated fixed combination or placebo eye drops...
September 11, 2018: Journal of Ocular Pharmacology and Therapeutics
Leonard K Seibold, Brandie D Wagner, Anne M Lynch, Malik Y Kahook
PURPOSE: The purpose of the study was to determine the 24-h effects of pilocarpine 2% ophthalmic solution on intraocular pressure (IOP) and ocular perfusion pressure (OPP) when used in addition to prostaglandin analog (PGA) therapy. METHODS: Twenty-seven patients with ocular hypertension (OHTN) or open angle glaucoma who were receiving stable monotherapy with a PGA were admitted to an inpatient sleep laboratory for 24-h monitoring of IOP, blood pressure (BP), and heart rate over 2 separate visits...
September 7, 2018: Journal of Ocular Pharmacology and Therapeutics
Sudeep Kumar Gade, Nagaveni Shivshetty, Natalia Sharma, Shubhmita Bhatnagar, Prashant Garg, Venkata Vamsi Krishna Venuganti
PURPOSE: The aim of the study was to develop a novel formulation of levofloxacin and besifloxacin to achieve improved mucoadhesion and permeability of besifloxacin and levofloxacin through cornea for the effective treatment of ocular infections. METHODS: A multicomponent hydrogel formulation containing chitosan-polyvinyl alcohol (PVA)-poly(N-vinylpyrrolidone) (PVP) was designed. Lysophosphatidylcholine was used to enhance corneal penetration of the drugs. The hydrogel preparations were characterized for various parameters, including clarity, pH, viscosity, in vitro release kinetics, mucoadhesion, ex vivo human corneal permeation, and antimicrobial efficacy...
August 23, 2018: Journal of Ocular Pharmacology and Therapeutics
Amina Rezkallah, Ariane Malclès, Corinne Dot, Nicolas Voirin, Émilie Agard, Anne-Laure Vié, Philippe Denis, Thibaud Mathis, Laurent Kodjikian
PURPOSE: To compare the efficacy and safety of the dexamethasone intravitreal implant of vitrectomized and nonvitrectomized eyes in real-world conditions. METHODS: This was a retrospective, multicenter, observational study. All consecutive patients presenting with at least one 0.7-mg intravitreal injection (IVI) of DEX implant from October 2010 to February 2015 were included in this study. Three hundred sixty-eight eyes in 330 patients were studied. Sixty-seven eyes were vitrectomized at baseline, 301 had not undergone vitrectomy at the last visit...
August 17, 2018: Journal of Ocular Pharmacology and Therapeutics
Alessandra Vecchione, Francesco Celandroni, Antonella Lupetti, Eleonora Favuzza, Rita Mencucci, Emilia Ghelardi
PURPOSE: The aim of this study was to evaluate the antimicrobial activity of a novel preservative-free lid wipe formulation containing Aloe vera gel and hyaluronic acid that is commercialized for the hygiene of the periocular area. METHODS: In vitro susceptibility testing of the solution contained in wipes against bacteria and fungi commonly colonizing the periocular area, both reference strains and multidrug-resistant (MDR) clinical isolates, was assessed following the CLSI M07-A9 and M27-A3 broth methods, respectively...
August 10, 2018: Journal of Ocular Pharmacology and Therapeutics
In Cheon You, Ying Li, Rujun Jin, Min Ahn, Won Choi, Kyung Chul Yoon
PURPOSE: To compare the efficacy of 0.1%, 0.18%, and 0.3% hyaluronic acid (HA) artificial tear in the treatment of experimental dry eye (EDE). METHODS: EDE was established in female C57BL/6 mice through an air draft and subcutaneous scopolamine injection. The mice were divided into 5 groups according to topical treatment regimens (n = 5 each): EDE control, balanced salt solution (BSS), preservative-free 0.1% HA, 0.18% HA, and 0.3% HA. The tear film break-up time (TBUT) and corneal fluorescein staining scores were measured 5, 10, 14, 21, and 28 days after treatment...
July 23, 2018: Journal of Ocular Pharmacology and Therapeutics
Adrian Will-Orrego, Yubin Qiu, Elizabeth S Fassbender, Siyuan Shen, Jorge Aranda, Namrata Kotagiri, Michael Maker, Sha-Mei Liao, Bruce D Jaffee, Stephen H Poor
PURPOSE: Mononuclear phagocytes (MNPs) are present in neovascular age-related macular degeneration (nv AMD) which is also called choroidal neovascularization (CNV). The number and phenotype of the MNPs depend upon the local environment in the CNV and effect of nv AMD therapy. We investigated ocular cell infiltration and conditions that modulate angiogenesis in a laser-induced mouse CNV model. METHODS: We developed assays to quantify MNPs in our established mouse CNV model...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Gary D Novack
No abstract text is available yet for this article.
September 2018: Journal of Ocular Pharmacology and Therapeutics
Julian Garcìa-Feijoo, Helmut Höh, Rossen Uzunov, Jaime E Dickerson
PURPOSE: The aim of the study was to report longer term (24-month) outcomes for primary open-angle glaucoma (POAG) patients refractory to medical therapy implanted with a supraciliary microstent (CyPass Micro-Stent, Alcon) in the DUETTE clinical study. METHODS: Sixty-five eyes were enrolled in this multicenter single-arm trial. Enrolled patients had POAG and intraocular pressure (IOP) >21 mmHg at baseline on 1-4 ocular hypotensive medications. Microstent implantation was performed as stand-alone surgery in these phakic or pseudophakic patients through a standard clear corneal approach...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Ying-Cheng Lin, Lin-Yea Horng, Hui-Ching Sung, Rong-Tsun Wu
PURPOSE: Low doses of sodium iodate (NaIO3 ) impair visual function in experimental animals with selective damage to retinal pigment epithelium (RPE) and serve as a useful model to study diseases caused by RPE degeneration. Mitochondrial dysfunction and defective autophagy have been suggested to play important roles in normal aging as well as many neurodegenerative diseases. In this study, we examined whether NaIO3 treatment disrupted the mitochondrial-lysosomal axis in cultured RPE. METHODS: The human RPE cell line, ARPE-19, was treated with low concentrations (≤500 μM) of NaIO3 ...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Masahiro Fuwa, Carol B Toris, Shan Fan, Takazumi Taniguchi, Masaki Ichikawa, Noriko Odani-Kawabata, Ryo Iwamura, Kenji Yoneda, Takeshi Matsugi, Naveed K Shams, Jin-Zhong Zhang
PURPOSE: To investigate the mechanism of the intraocular pressure (IOP)-lowering effect of a novel selective prostaglandin E2 receptor 2 (EP2) receptor agonist, omidenepag isopropyl (OMDI). METHODS: The effect of OMDI on IOP and aqueous humor dynamics was evaluated in cynomolgus monkeys with unilateral laser-induced ocular hypertension. In a crossover manner, the hypertensive eye of each monkey was dosed once daily with 20 μL of either 0.002% OMDI or vehicle...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Rodrigo Guimaraes de Souza, Zhiyuan Yu, Michael E Stern, Stephen C Pflugfelder, Cintia S de Paiva
PURPOSE: Increased interferon gamma (IFN-γ) expression in dry eye causes ocular surface epithelial disease termed keratoconjunctivitis sicca (KCS). The purpose of this study was to investigated the effects of the LFA-1 antagonist, lifitegrast, in a mouse desiccating stress (DS) dry eye model that develops KCS similar to Sjögren syndrome. METHODS: Mice were treated with vehicle or lifitegrast twice daily for 5 days and expression of Th1 family genes (IFN-γ, CXCL9, and CXCL11) was evaluated by real-time polymerase chain reaction...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Christina L Rettinger, Heuy-Ching Wang
PURPOSE: Given that porcine and human retinas have similar structures and characteristics, ex vivo culture of porcine neuroretina provides an attractive model for studying mechanisms of human retinal injury and degenerative disease. Here, we describe the method that was used to establish and characterize an adult porcine retina culture system as a rapid screening tool for retinal survival in real time. METHODS: Neuroretina explants 8 mm in diameter were harvested from adult swine and cultured on porous cell culture inserts with adjustable heights...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Ghulam Mohammad, Saleh Hamed Alrashed, Abdullah Ibrahim Almater, Mohammad Mairaj Siddiquei, Ahmed M Abu El-Asrar
PURPOSE: To examine the effects of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitor 1,5-isoquinolinediol (IQ) on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived oxidative stress in diabetic retina. METHODS: Streptozotocin-induced diabetic rats were treated with IQ. The NADPH oxidase enzyme activity was determined by luminometer. Expression of gp91phox , P47phox and nitrated proteins was examined by western blot. Interaction between gp91phox and P47phox was determined by coimmunoprecipitation...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Jinsoo Kim, Dong Chul Choi, Seokhyun Bae, Dong Gyu Choi, Joo Yeon Lee
PURPOSE: To evaluate the comparative effects and safety of topical diclofenac sodium, fluorometholone, and dexamethasone for controlling inflammation after routine strabismus surgery. METHODS: This was a randomized clinical trial. Ninety-nine patients admitted for surgery to treat intermittent exotropia were randomly assigned to receive 1 of 3 postoperative eye drops between January 2015 and February 2016. The primary efficacy outcomes were pain and conjunctival injection...
September 2018: Journal of Ocular Pharmacology and Therapeutics
Makoto Aihara
No abstract text is available yet for this article.
July 2018: Journal of Ocular Pharmacology and Therapeutics
Frederick T Fraunfelder, Frederick W Fraunfelder
PURPOSE: To evaluate possible associations between oral anti-vascular endothelial growth factor (VEGF) drugs and ocular side effects. METHODS: Spontaneous reports were collected and evaluated by the National Registry of Drug-Induced Ocular Side Effects on the three oral anti-VEGF drugs (pazopanib, sorafenib, and sunitinib) for possible ocular side effects. RESULTS: Reported side effects include blurred or decreased vision (389 cases); periocular or eyelid edema (273 cases); superficial anterior segment toxicity (270 cases); conjunctival, retinal, or vitreous bleeding (77 cases); retinal detachments (RDs) or retinal tears (RTs) (75 cases); extraocular muscle disorders, including ptosis (51 cases); discoloration of eyelashes (36 cases); retinal arterial or venous occlusions (26 cases); optic nerve disorders, including papilledema and ischemic optic neuropathy (21 cases); uveitis (10 cases); and macular edema (7 cases)...
July 2018: Journal of Ocular Pharmacology and Therapeutics
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