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Journal of Ocular Pharmacology and Therapeutics

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https://www.readbyqxmd.com/read/27923107/an-alternative-to-topical-dosing-to-deliver-drugs-to-target-tissues
#1
L David Waterbury
No abstract text is available yet for this article.
December 6, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27906556/combination-effect-of-cefuroxime-and-levofloxacin-against-bacteria-isolated-from-the-healthy-conjunctival-sac-and-endophthalmitis-cases-using-a-fractional-inhibitory-concentration-index
#2
Takashi Suzuki, Toshihiro Yamamoto, Tomohiko Torikai, Yuichi Ohashi
PURPOSE: Intracameral cefuroxime (CXM) and antibiotic eye drops such as fluoroquinolone are widely used for preventing endophthalmitis after cataract surgery. However, few reports are available regarding their interactions. This study was conducted to examine the in vitro interaction of CXM and levofloxacin (LVFX) against bacterial isolates from the healthy conjunctival sac before cataract surgery and from endophthalmitis cases. METHODS: The activity of each drug was determined using a broth dilution method...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27906544/lfa-1-icam-1-interaction-as-a-therapeutic-target-in-dry-eye-disease
#3
Stephen C Pflugfelder, Michael Stern, Steven Zhang, Amir Shojaei
Dry eye disease (DED) is a common ocular disorder associated with inflammation of the lacrimal gland and ocular surface. The interaction of the integrin lymphocyte function-associated antigen-1 (LFA-1) with its cognate ligand intercellular adhesion molecule-1 (ICAM-1) is known to have important roles in the interaction of a variety of cells involved in immune responses and inflammation, including those prominent in ocular surface inflammation. Lifitegrast, an LFA-1 antagonist that blocks binding of ICAM-1 to LFA-1, has recently been approved in the United States for the treatment of signs and symptoms of DED...
December 1, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27835059/epalrestat-an-aldose-reductase-inhibitor-prevents-glucose-induced-toxicity-in-human-retinal-pigment-epithelial-cells-in-vitro
#4
Srinivasan Senthilkumari, Rajendran Sharmila, Gowripriya Chidambaranathan, Ayyasamy Vanniarajan
PURPOSE: Aldose reductase (ALR), the first and rate-limiting enzyme involved in polyol pathway plays a central role in diabetes and its related complications, including diabetic retinopathy (DR). Inhibition of ALR may also be an ideal target for reducing the deleterious effects of DR. Therefore, the purpose of the present study was to investigate the protective effect of epalrestat (EPL), ALR inhibitor on glucose-induced toxicity in ARPE-19 cells. METHODS: ARPE-19 cells were challenged with normal glucose (NG, 5 mM) and high glucose (HG1, 25 mM and HG2, 50 mM) in the presence or absence of EPL...
November 11, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27828721/change-in-central-corneal-thickness-after-the-discontinuation-of-latanoprost-in-normal-tension-glaucoma-change-in-central-corneal-thickness-after-stop-of-latanoprost
#5
Romi Yoo, Youn A Choi, Byung Joo Cho
PURPOSE: To assess the impact of latanoprost on central corneal thickness (CCT) after ceasing medication in patients with normal tension glaucoma (NTG). METHODS: A total of 46 eyes from 46 NTG patients, and 44 eyes from 44 individuals with glaucoma suspect (controls), were included in this retrospective study. Newly diagnosed early NTG patients (visual field mean deviation >-6.00) were administered latanoprost 0.005% monotherapy once a day. CCTs were measured by ultrasound pachymetry before treatment, for 5 years during treatment, and for 2 years after ceasing treatment...
November 9, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27763812/prostanoid-receptor-antagonist-effects-on-intraocular-pressure-supported-by-ocular-biodisposition-experiments
#6
David F Woodward, Stacey L Wenthur, Tara L Rudebush, Shan Fan, Carol B Toris
PURPOSE: Since all prostanoid receptors affect intraocular pressure (IOP) and endogenous prostanoids are found in ocular tissues, the pressor effects of prostanoid antagonists were comprehensively evaluated. The absence of effects of most of these antagonists was not entirely anticipated. To ensure no false-negative results, ocular biodisposition studies were conducted. METHODS: Monkeys with laser-induced ocular hypertension were used to study antagonist effects on IOP...
October 20, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27754810/eyes-on-new-product-development
#7
Gary D Novack
No abstract text is available yet for this article.
October 18, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27754738/noninvasive-electroretinography-assessment-of-intravitreal-sustained-release-methotrexate-microimplants-in-rabbit-eyes
#8
Soumyarwit Manna, James J Augsburger, Zelia M Correa, Marwan F Al-Rjoub, Marepalli B Rao, Rupak K Banerjee
PURPOSE: The purpose of this study is to noninvasively evaluate the safety and toxicity of a chitosan (CS) and polylactic acid (PLA)-based sustained-release methotrexate (MTX) intravitreal microimplant in normal rabbit eyes using electroretinography (ERG). METHODS: PLA-coated CS-based microimplants containing 400 μg of MTX and placebo microimplants (without drug) were surgically implanted in the vitreous of the right and the left eyes, respectively, in each of the 8 New Zealand rabbits using minimally invasive technique...
October 18, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27652887/drug-loaded-nanoparticles-embedded-in-a-biomembrane-provide-a-dual-release-mechanism-for-drug-delivery-to-the-eye
#9
Munish Sharma, Rudra Bhowmick, Heather Gappa-Fahlenkamp
PURPOSE: Topical delivery by eye drops, which accounts for ∼90% of all ophthalmic formulations, is inefficient for drug delivery to the posterior segment. Only 5% of the drug applied as drops reaches the target, whereas the rest is lost through tear drainage. A number of conditions such as glaucoma and proliferative retinopathy need sustained drug release to be therapeutically effective. The purpose of this study was to develop a novel dual-release drug delivery system to meet this requirement...
September 21, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27652776/introduction-to-purinergic-regulation-in-the-eye-special-issue
#10
Claire H Mitchell, Mortimer M Civan
No abstract text is available yet for this article.
September 21, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27652667/dedication-of-special-issue-on-purinergic-regulation-in-the-eye-to-mortimer-m-civan
#11
Claire H Mitchell, W Daniel Stamer
No abstract text is available yet for this article.
September 21, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27922804/correction-to-journal-of-ocular-pharmacology-and-therapeutics-2016-32-355-364
#12
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27922803/correction-to-journal-of-ocular-pharmacology-and-therapeutics-2016-32-606-622
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27875665/eyes-on-new-product-development
#14
Gary D Novack
No abstract text is available yet for this article.
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27860530/retinal-nerve-fiber-layer-thickness-changes-in-age-related-macular-degeneration-treated-with-multiple-intravitreal-ranibizumab
#15
Elvan Alper Sengul, Ozgur Artunay, Esra Turkseven Kumral, Melda Yenerel, Rifat Rasier, Alev Kockar, Erdal Yuzbasioglu
PURPOSE: The objective of this study was to investigate the effect of multiple intravitreal ranibizumab (IVR) injections on the retinal nerve fiber layer (RNFL) in neovascular age-related macular degeneration (nAMD). METHODS: One hundred sixty-eight eyes of 168 patients with nAMD who received an IVR at least 3 times were included in this prospective interventional case series. The RNFL thickness data on 80 healthy eyes, used as the control group, were obtained. The patients were grouped as follows: 3-10 injections (group 1, 62 eyes, 37%), 10-20 injections (group 2, 62 eyes, 37%), and ≥20 injections (group 3, 44 eyes, 26%)...
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27849435/targeted-drug-delivery-within-the-eye-through-the-suprachoroidal-space
#16
Samirkumar R Patel, Mark R Prausnitz
No abstract text is available yet for this article.
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27835065/sustained-delivery-of-timolol-maleate-for-over-90-days-by-subconjunctival-injection
#17
Erin Lavik, Markus H Kuehn, Andrew J Shoffstall, Kristyn Atkins, Alina V Dumitrescu, Young H Kwon
PURPOSE: Medical treatment of glaucoma relies on intraocular pressure (IOP)-lowering medications, typically administered daily by the patient. While these medications are effective when applied correctly, patient adherence is a major obstacle in glaucoma treatment. We have developed a sustained-release formulation of timolol maleate that can be injected subconjunctivally to avoid patient noncompliance. METHODS: A biodegradable microsphere formulation for timolol maleate was injected subconjunctivally in normal rabbits...
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27830980/mucous-membrane-grafting-augmented-with-topical-mitomycin-c-application-in-contracted-socket-repair-surgeries
#18
Sameh S Mandour, Hesham M Elmazar, Hatem M Marey, Ahmed K Abdel Rahman, Rokia A Sakr
PURPOSE: To evaluate the use of intraoperative topical application of mitomycin C (MMC) for managing cases of recurrent socket contraction. METHODS: A prospective comparative randomized study was carried out on 40 patients suffering from contracted sockets. They were randomly enrolled into 2 groups. Group A included 20 patients who had a surgery to treat contracted socket without augmentation with MMC. Group B patients had an MMC-augmented repair for the contracted socket...
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27827554/differential-effects-of-bevacizumab-ranibizumab-and-aflibercept-on-the-viability-and-wound-healing-of-corneal-epithelial-cells
#19
Seungbum Kang, Hyunsu Choi, Chang Rae Rho
PURPOSE: This study compared the effects of 3 antivascular endothelial growth factor (VEGF) agents (bevacizumab, ranibizumab, and aflibercept) on corneal epithelial cell viability and wound healing using human corneal epithelial cells (HCECs). METHODS: To determine the cytotoxic effects of anti-VEGF agents on HCECs, HCEC viability was determined at various concentrations of these agents. An in vitro migration assay was used to investigate the migration of HCECs treated with 3 anti-VEGF agents...
December 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27788033/effects-of-antipsychotic-drugs-haloperidol-and-clozapine-on-visual-responses-of-retinal-ganglion-cells-in-a-rat-model-of-retinitis-pigmentosa
#20
Ralph J Jensen
PURPOSE: In the P23H rat model of retinitis pigmentosa, the dopamine D2 receptor antagonists sulpiride and eticlopride appear to improve visual responses of retinal ganglion cells (RGCs) by increasing light sensitivity of RGCs and transforming abnormal, long-latency ON-center RGCs into OFF-center cells. Antipsychotic drugs are believed to mediate their therapeutic benefits by blocking D2 receptors. This investigation was conducted to test whether haloperidol (a typical antipsychotic drug) and clozapine (an atypical antipsychotic drug) could similarly alter the light responses of RGCs in the P23H rat retina...
December 2016: Journal of Ocular Pharmacology and Therapeutics
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