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Journal of Ocular Pharmacology and Therapeutics

Xin Zhao, Yang Tong, Xiaotong Wang, Xian Zhang, Shichao Chen, Hong Lu
PURPOSE: To investigate the ocular penetration of natamycin (NAT) and voriconazole (VRC) after topical instillation in New Zealand white rabbits using simplified liquid chromatography-tandem mass spectrometry (LC-MS/MS) and high-performance liquid chromatography. METHODS: Seventy-eight healthy rabbits were randomly divided into 3 groups. In the first 2 groups, 72 rabbits were used for single-dose testing (36 for NAT, 36 for VRC), in which 50 μL of 5.0% NAT or 1...
May 24, 2018: Journal of Ocular Pharmacology and Therapeutics
Jinsoo Kim, Dong Chul Choi, Seokhyun Bae, Dong Gyu Choi, Joo Yeon Lee
PURPOSE: To evaluate the comparative effects and safety of topical diclofenac sodium, fluorometholone, and dexamethasone for controlling inflammation after routine strabismus surgery. METHODS: This was a randomized clinical trial. Ninety-nine patients admitted for surgery to treat intermittent exotropia were randomly assigned to receive 1 of 3 postoperative eye drops between January 2015 and February 2016. The primary efficacy outcomes were pain and conjunctival injection...
May 21, 2018: Journal of Ocular Pharmacology and Therapeutics
Tutul Chakravarti
PURPOSE: To evaluate the association of socioeconomic status (SES) with severity of glaucoma and assess the impacts of both SES and disease-severity factors on the costs of glaucoma medications among different glaucoma subtypes in West Bengal, India. METHODS: This cross-sectional study (2014-16) followed the treatment of 304 primary glaucoma patients for at least 18 months. The visual field based glaucoma staging was followed for stages 0-3; patients with field of vision <10° were categorized as stage 4 (end stage)...
May 15, 2018: Journal of Ocular Pharmacology and Therapeutics
Yang Kyung Cho, Eun Young Shin, Hironori Uehara, Balamurali Ambati
PURPOSE: To investigate the anti(lymph)angiogenic and anti-inflammatory effects of 0.5% timolol maleate in a murine corneal suture model. METHODS: Corneal neovascularization and lymphangiogenesis were compared in groups of mice that underwent corneal suture and were subsequently administered a subconjunctival injection of 0.5% timolol maleate, dexamethasone, or phosphate-buffered saline (PBS). Immunohistochemical staining and analysis were performed in each group...
May 14, 2018: Journal of Ocular Pharmacology and Therapeutics
Gary D Novack
No abstract text is available yet for this article.
May 9, 2018: Journal of Ocular Pharmacology and Therapeutics
Huy D M Tran, Yen H Tran, Tuan D Tran, Monica Jong, Minas Coroneo, Padmaja Sankaridurg
Myopia is a global public health issue with a worldwide prevalence of ∼30% and is estimated to rise to 50% by 2050. In addition to the burden associated with routine management of the condition, high myopia predisposes the eye to sight-threatening complications such as myopic maculopathy and glaucoma in adult life. Controlling onset and progression of myopia at a young age can reduce the risk of morbidity associated with high myopia. Progression of myopia can be slowed with various optical, environmental, and pharmaceutical strategies, of which atropine has proven to be the most effective...
May 1, 2018: Journal of Ocular Pharmacology and Therapeutics
Lionel Sebbag, Lucas Showman, Emily M McDowell, Ann Perera, Jonathan P Mochel
PURPOSE: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges following oral drug administration. METHODS: Three dogs and 3 cats were administered doxycycline orally at a dose of 4.2-5 mg/kg every 12 h for 6 consecutive days. At day 5 and 6, blood and tear fluid were sampled to capture doxycycline trough and maximal concentrations. Tear fluid was collected 3 times (spaced 10 min apart) at each session with the absorbent material placed in the lower conjunctival fornix until the 20-mm mark was reached (Schirmer strip, one eye) or for 1 min (PVA sponge, other eye)...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
Andrew Smith, Mercy Pawar, Marcian E Van Dort, Stefanie Galbán, Amanda R Welton, Greg M Thurber, Brian D Ross, Cagri G Besirli
PURPOSE: ST-162 and ST-168 are small-molecule bifunctional inhibitors of MEK and PI3K signaling pathways that are being developed as novel antitumor agents. Previous small-molecule and biologic MEK inhibitors demonstrated ocular toxicity events that were dose limiting in clinical studies. We evaluated in vitro and in vivo ocular toxicity profiles of ST-162 and ST-168. METHODS: Photoreceptor cell line 661W and adult retinal pigment epithelium cell line ARPE-19 were treated with increasing concentrations of bifunctional inhibitors...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
Gonzaga Garay-Aramburu, Ángela Gómez-Moreno
PURPOSE: To evaluate the long-term effects of intravitreal dexamethasone implants (IDIs) in eyes with macular edema (ME) due to retinal vein occlusion (RVO). METHODS: We reviewed the records of 10 patients followed for 5 years after they received their first IDI. The main outcome measures included changes in best corrected visual acuity (BCVA), central macular thickness (CMT), and central macular volume (CMV), and the incidence of side effects. RESULTS: Ten patients were included in the study with a mean follow-up of 65...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
Gary D Novack
No abstract text is available yet for this article.
April 2, 2018: Journal of Ocular Pharmacology and Therapeutics
Ngamkae Ruangvaravate, Pinnita Prabhasawat, Virunya Vachirasakchai, Ratchadaporn Tantimala
PURPOSE: To determine the prevalence of symptoms and signs of ocular surface disease (OSD) among Thai patients with glaucoma receiving topical intraocular pressure (IOP)-lowering therapy. METHODS: Consecutive patients with glaucoma were recruited prospectively for this cross-sectional study from Siriraj Hospital. Subjective symptoms were evaluated using the Ocular Surface Disease Index (OSDI), and objective clinical signs were evaluated using the tear breakup time (TBUT), corneal fluorescein, rose bengal staining, and the Schirmer test...
March 29, 2018: Journal of Ocular Pharmacology and Therapeutics
Juan C Altamirano-Vallejo, Jose Navarro-Partida, Alejandro Gonzalez-De la Rosa, Jane H Hsiao, Jose S Olguín-Gutierrez, Ana C Gonzalez-Villegas, Brian C Keller, Lourdes Bouzo-Lopez, Arturo Santos
PURPOSE: To achieve a safer alternative to intravitreal injection of corticosteroids, we developed and characterized triamcinolone acetonide-loaded liposomes formulations (TA-LFs) to be used topically for vitreoretinal drug delivery. METHODS: Four different 0.2% TA-LFs (TA-LF1 to TA-LF4) were generated and submitted to physicochemical characterization. Posteriorly, an ex vivo diffusion assay was performed using rabbit corneas as membranes. Finally, concentrations of triamcinolone acetonide (TA) were determined by high-performance liquid chromatography in ocular tissues from New Zealand white rabbits after multiple topical doses of TA-LF2 (6 times per day, 14 days)...
March 27, 2018: Journal of Ocular Pharmacology and Therapeutics
Shaopin Zhu, Xun Xu, Kun Liu, Qing Gu, Fang Wei, Xiaolu Yang
PURPOSE: To assess the anti-inflammatory effect and mechanism of a novel peptide, PAPep, in poly(I:C)-stimulated corneal fibroblasts. METHODS: Corneal fibroblasts were treated with poly(I:C) to elicit inflammation. Real-time polymerase chain reaction (PCR) and ELISA were used to measure the mRNA and protein levels of interleukin (IL)-6, monocyte chemotactic factor (MCP)-1, and interferon gamma (IFN-γ). Real-time PCR, immunofluorescence, and immunoblot were performed to determine ICAM-1 expression...
March 27, 2018: Journal of Ocular Pharmacology and Therapeutics
Elvin Yildiz, Nursal Melda Yenerel, Ayca Turan-Yardimci, Murat Erkan, Pembegul Gunes
PURPOSE: To compare the clinical efficacy of topical and oral azithromycin treatments for posterior blepharitis. METHODS: Both topical and oral treatment groups comprised 15 patients. In the topical group, azithromycin 15 mg/g ophthalmic solution (Azyter; Thea Pharmaceuticals, Clermont-Ferrand, France) was used twice a day for 3 days and then once a day until the treatment completes a month. In the systemic treatment group, azithromycin 250 mg tablets (Azitro; Deva Pharmaceuticals, Istanbul, Turkey) were used, 1 × 2 tablets (500 mg) at the first day of treatment and then 1 × 1 tablet (250 mg) for 4 days...
May 2018: Journal of Ocular Pharmacology and Therapeutics
Leopoldo Baiza-Durán, Oscar Olvera-Montaño, Arieh R Mercado-Sesma, Aldo A Oregon-Miranda, Alfredo Lizárraga-Corona, Juan C Ochoa-Tabares, Ana L Pérez-Balbuena, Irene M Montoya-Sánchez, Laura R Saucedo-Rodríguez, Alfredo Mora-González, Pedro A Gómez-Bastar, Miguel A Villanueva-Najera, Laura I Sandoval-Delgadillo, M González-Lomelí, Juan H Páez-Garza, Mónica Orozco-Carroll, Mauricio Casillas-Magallanes
PURPOSE: The purpose of this study was to evaluate the clinical efficacy and safety of a novel ophthalmic solution of pazufloxacin on the ocular surface of patients with bacterial conjunctivitis after 7 days of intervention. METHODS: This is a phase 2, double-blind, controlled, multicenter, clinical trial of 300 subjects, randomized to either a 3 dosing regimen of pazufloxacin 0.6% ophthalmic solution (twice a day [BID], n = 90; 3 times a day [TID], n = 76; 4 times a day [QID], n = 68), moxifloxacin 0...
April 2018: Journal of Ocular Pharmacology and Therapeutics
Gary D Novack
No abstract text is available yet for this article.
April 2018: Journal of Ocular Pharmacology and Therapeutics
Gary D Novack, Elizabeth D Moyer
No abstract text is available yet for this article.
April 2018: Journal of Ocular Pharmacology and Therapeutics
Alper Yazıcı, Esin Sarı, Erkan Ayhan, Gözde Şahin, Nesime Setge Tıskaoğlu, Taha Gürbüzer, Hüseyin Kurt, Sıtkı Samet Ermiş
PURPOSE: To evaluate the effects of acetylsalicylic acid (aspirin) on tear film parameters and dry eye disease. METHODS: Fifty-seven patients using low-dose aspirin regularly for antiaggregant purposes as well as 49 controls, who required antiaggregant treatment but who had not yet started, were included in the study. Tear osmolarity, tear break-up time (TBUT), Schirmer and Oxford grading of ocular surface staining were performed on all patients and dry eye symptomatology was assessed using the ocular surface disease index questionnaire (OSDI)...
April 2018: Journal of Ocular Pharmacology and Therapeutics
Yuko Sekine, Marie Shimada, Shoko Satake, Masato Okubo, Akihiro Hisaka, Tadashi Hara, Megumi Honjo, Makoto Aihara
PURPOSE: To investigate the effect of excipients on latanoprost penetration into the aqueous humor with clinically available 6 products with different solutions mainly in the types and concentrations of preservatives. METHODS: In 363 patients with cataracts, we instilled 1 latanoprost drop in 1 eye before surgery. The drop was randomly selected by brand name product (A) and 5 generic products (B-F) composed with different excipients. B contains similar excipients to A...
April 2018: Journal of Ocular Pharmacology and Therapeutics
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