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Archives of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/28084108/enhanced-hepatic-insulin-signaling-in-the-livers-of-high-altitude-native-rats-under-basal-conditions-and-in-the-livers-of-low-altitude-native-rats-under-insulin-stimulation-a-mechanistic-study
#1
Hussain Al Dera, Samy M Eleawa, Fahaid H Al-Hashem, Moeber M Mahzari, Ibrahim Hoja, Mahmoud Al Khateeb
This study was designed to investigate the role of the liver in lowering fasting blood glucose levels (FBG) in rats native to high (HA) and low altitude (LA) areas. As compared with LA natives, besides the improved insulin and glucose tolerance, HA native rats had lower FBG, at least mediated by inhibition of hepatic gluconeogenesis and activation of glycogen synthesis. An effect that is mediated by the enhancement of hepatic insulin signaling mediated by the decreased phosphorylation of TSC induced inhibition of mTOR function...
January 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28019102/arecoline-aggravates-hypothyroidism-in-metabolic-stress-in-mice
#2
Romi Dasgupta, Aniruddha Chatterjee, Supriti Sarkar, B R Maiti
Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress was investigated in mice. Water or food-deprivation, each for 5 days, caused ultrastructural degeneration of thyro-follicular cells, evident from pycnotic nuclei, scanty rough endoplasmic reticulum and mitochondria followed by depletion of blood serum T3 and T4 levels with alteration of TSH level as compared with control...
December 26, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28019124/immediate-and-residual-effects-of-low-dose-nandrolone-decanoate-and-treadmill-training-on-adipose-and-reproductive-tissues-of-male-wistar-rats
#3
Josilene M Rodrigues, Vinicius P P Oliveira, Julia P Furlan, Ana Claudia Munhoz, Marcelo R S Rempel, Marcia N Brito, Nilton A Brito, Maria M D Pedrosa, Cecília E M Costa
CONTEXT: Residual effects after nandrolone decanoate (ND) treatment are not reported. OBJECTIVE: Immediate and residual effects of low-dose ND and treadmill training were investigated. MATERIALS AND METHODS: Male rats were trained and/or ND-treated for four weeks and the assessments were made after this period or four weeks later. RESULTS: The groups did not differ in final plasma glucose or AUC of the ivGTT, but hyperinsulinemia was noticed in some trained/treated groups...
December 25, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28019119/evaluation-of-bacillus-subtilis-spb1-biosurfactant-effects-on-hyperglycemia-angiotensin-i-converting-enzyme-ace-activity-and-kidney-function-in-rats-fed-on-high-fat-high-fructose-diet
#4
Raida Zouari, Khaled Hamden, Abdelfattah El Feki, Khansa Chaabouni, Fatma Makni-Ayadi, Fahima Sallemi, Semia Ellouze-Chaabouni, Dhouha Ghribi-Aydi
This study investigated the protective and the curative effects of Bacillus subtilis SPB1 crude lipopeptide biosurfactant in alleviating induced obesity complications in rats fed on high-fat-high-fructose diet (HFFD). Male Wistar rats were divided into five groups with the following treatment schedule: normal diet-fed rats (CD), HFFD-fed rats, HFFD-fed rats supplemented with SPB1 biosurfactant from the first day of the experiment (HFFD + Bios1), rats fed on HFFD receiving standard drug (HFFD + Torva), or SPB1 biosurfactant (HFFD + Bios2) during the last 4 weeks of the study...
December 25, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28005432/-catechin-prevents-methylglyoxal-induced-mitochondrial-dysfunction-and-apoptosis-in-ea-hy926-cells
#5
Tianyu Zhang, Yingying Mu, Mingqi Yang, Abdullah Al Maruf, Panpan Li, Chao Li, Shaohua Dai, Jiangyi Lu, Qiang Dong
OBJECTIVE: To investigate whether (+)-catechin, a strong antioxidant, can prevent methylglyoxal (MGO)-induced cytotoxicity and its mechanism. METHODS: Cytotoxicity, apoptosis, reactive oxygen species (ROS) generation, hydrogen peroxide (H2O2) formation, mitochondrial membrane potential (MMP) and mitochondrial morphology were measured in EA.hy926 cells. RESULT: MGO (4 mM)-induced cytotoxicity was markedly inhibited by (+)-catechin (0.1-4 mM) in 24 h...
December 22, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27960552/chemical-composition-phytochemical-constituents-antioxidant-and-anti-inflammatory-activities-of-urtica-urens-l-leaves
#6
Massara Mzid, Sameh Ben Khedir, Sana Bardaa, Zouheir Sahnoun, Tarek Rebai
OBJECTIVE: The aim of this study was to investigate the chemical composition and antioxidant properties of Urtica urens L.(Uu) as well as its anti-inflammatory effect on carrageenan (CARR)-induced paw oedema in rats. METHODS: The leaves were extracted using ethanol (EtOH) and water. The extracts were analysed for proximate composition and antioxidant activity using standard chemical analysis methods. RESULTS: The proximate analysis showed that Uu leaves contained appreciable percentages of dry mass, ashes, carbohydrates, proteins, lipids, sugars, anthocyanin, carotenoid and fibre...
December 14, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27960551/date-fruits-inhibit-hepatocyte-apoptosis-and-modulate-the-expression-of-hepatocyte-growth-factor-cytochrome-p450-2e1-and-heme-oxygenase-1-in-carbon-tetrachloride-induced-liver-fibrosis
#7
Nouf M Al-Rasheed, Hala A Attia, Raeesa A Mohamad, Nawal M Al-Rasheed, Musaed Al Fayez, Maha A Al-Amin
CONTEXT: Date fruits have protective effects against liver fibrosis; however their anti-apoptotic effects have not been investigated. OBJECTIVE: To investigate the modulating effects of date fruits on pro- and anti-apoptotic markers, cytochrome P450 2E1 (CYP2E1) and hepatocyte growth factor (HGF) in liver fibrosis. MATERIALS AND METHODS: Liver fibrosis was induced by injection of carbon tetrachloride (CCl4) for eight weeks. Date flesh extract (DFE) and pits extract (DPE) were taken daily concomitant with CCl4...
December 14, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27855519/xanthohumol-from-hop-cones-humulus-lupulus-l-prevents-adp-induced-platelet-reactivity
#8
Boguslawa Luzak, Hassan Kassassir, Edward Rój, Lidia Stanczyk, Cezary Watala, Jacek Golanski
Hop cones (Humulus lupulus L.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop cones, was investigated. XN significantly attenuated ADP-induced blood platelet aggregation (97.2 ± 35.7 AU for 6 μg/ml of XN vs. 120.4 ± 30.1 AU for 0.17% dimethyl sulfoxide (DMSO), p < 0...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27855518/pcr-arrays-indicate-that-the-expression-of-extracellular-matrix-and-cell-adhesion-genes-in-human-adipocytes-is-regulated-by-il-1%C3%AE-interleukin-1%C3%AE
#9
Malgorzata A Kępczyńska, Mohamed S Zaibi, Suliman Y Alomar, Paul Trayhurn
The role of IL-1β in regulating the expression of extracellular matrix (ECM) and cell adhesion genes in human adipocytes has been examined. Adipocytes differentiated in culture were incubated with IL-1β for 4 or 24 h and RNA probed with PCR arrays for 84 ECM and cell adhesion genes. Treatment with IL-1β resulted in changes in the expression at one or both time points of ∼50% of the genes probed by the arrays, the majority being down-regulated. Genes whose expression was down-regulated by IL-1β included those encoding several collagen chains and integrin subunits...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27855503/inhibitory-activities-of-cystoseira-crinita-sulfated-polysaccharide-on-key-enzymes-related-to-diabetes-and-hypertension-in-vitro-and-animal-study
#10
Amel Ben Gara, Rihab Ben Abdallah Kolsi, Neila Jardak, Rim Chaaben, Abdelfattah El-Feki, Lotfi Fki, Hafedh Belghith, Karima Belghith
The present study investigated the effect of the Cystoseira crinita sulfated polysaccharide (CCSP) on key enzymes activities related to diabetes in vitro and in diabetic rats. We found that CCSP inhibited pancreatic α-amylase with IC50 = 39.16 μg/ml and angiotensin I-converting enzyme (ACE) activity with IC50 = 58.35 μg/ml in vitro. In diabetic rats, the administration of CCSP reduced the activity of α-amylase in serum, pancreas, and intestine by 23%, 44.38%, and 45%, respectively as compared to untreated diabetic rats...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27808571/cytotoxic-t-lymphocyte-associated-protein-4-gene-polymorphism-is-related-to-rheumatoid-arthritis-in-egyptian-population
#11
Shaimaa A Fattah, Maivel H Ghattas, Samy M Saleh, Dina M Abo-Elmatty
CONTEXT: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a CD28-family receptor expressed on T-cells which suppresses T cell proliferation. CTLA-4 -318C/T polymorphism is involved in regulation of CTLA-4 expression. OBJECTIVE: The study aimed to investigate the genetic association of CTLA-4 -318C/T polymorphism with rheumatoid arthritis (RA) and the activity and severity of the disease in the Egyptian population. METHODS: A single nucleotide polymorphism (rs5742909) in CTLA-4 was genotyped in 100 RA patients and 100 healthy controls using polymerase chain reaction-restriction fragment length polymorphism...
November 3, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27808565/mass-spectrometry-in-life-science-research
#12
Stefan Lehr, Daniel Markgraf
Investigating complex signatures of biomolecules by mass spectrometry approaches has become indispensable in molecular life science research. Nowadays, various mass spectrometry-based omics technologies are available to monitor qualitative and quantitative changes within hundreds or thousands of biological active components, including proteins/peptides, lipids and metabolites. These comprehensive investigations have the potential to decipher the pathophysiology of disease development at a molecular level and to monitor the individual response of pharmacological treatment or lifestyle intervention...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27615280/oxygen-and-differentiation-status-modulate-the-effect-of-x-ray-irradiation-on-physiology-and-mitochondrial-proteome-of-human-neuroblastoma-cells
#13
Tamara Džinić, Sonja Hartwig, Stefan Lehr, Norbert A Dencher
Cytotoxic effects, including oxidative stress, of low linear energy transfer (LET)-ionizing radiation are often underestimated and studies of their mechanisms using cell culture models are widely conducted with cells cultivated at atmospheric oxygen that does not match its physiological levels in body tissues. Also, cell differentiation status plays a role in the outcome of experiments. We compared effects of 2 Gy X-ray irradiation on the physiology and mitochondrial proteome of nondifferentiated and human neuroblastoma (SH-SY5Y) cells treated with retinoic acid cultivated at 21% and 5% O2...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27595307/collagen-analysis-of-the-ascending-aortic-dilatation-associated-with-bicuspid-aortic-valve-disease-compared-with-tricuspid-aortic-valve
#14
Alexander Navarrete Santos, Junfeng Yan, Peter Lochmann, Heike Pfeil, Michael Petersen, Andreas Simm, Hendrik Treede, Hans H Sievers, Salah A Mohamed
Dilatation of the ascending aorta is a common occurrence in patients with bicuspid aortic valve (BAV). The aim of the current study was to characterize collagen content in advanced glycation end products (AGEs) of dilated aortic tissue from two distinct areas, concave and convex aortic sites in patients with BAV and TAV. Collagen contents extracted from 100 mg tissue was isolated by enzymatic digestion using pepsin and the nondigested material was further digested using cyanogen bromide, insoluble collagen fraction (ICF) was extracted by hydrochloric acid hydrolysis...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27494767/impact-of-fibroblast-growth-factor-21-on-the-secretome-of-human-perivascular-preadipocytes-and-adipocytes-a-targeted-proteomics-approach
#15
Lucia Berti, Sonja Hartwig, Martin Irmler, Bernhard Rädle, Dorothea Siegel-Axel, Johannes Beckers, Stefan Lehr, Hadi Al-Hasani, Hans-Ulrich Häring, Martin Hrabě de Angelis, Harald Staiger
CONTEXT: Perivascular adipose tissue (PVAT) is suggested to impact on vascular cells via humoral factors, possibly contributing to endothelial dysfunction and atherosclerosis. OBJECTIVE: To address whether the hepatokine fibroblast growth factor (FGF) 21 affects the PVAT secretome. METHODS: Human perivascular (pre)adipocytes were subjected to targeted proteomics and whole-genome gene expression analysis. RESULTS: Preadipocytes, as compared to adipocytes, secreted higher amounts of inflammatory cytokines and chemokines...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27467289/native-dige-proteomic-analysis-of-mitochondria-from-substantia-nigra-and-striatum-during-neuronal-degeneration-and-its-compensation-in-an-animal-model-of-early-parkinson-s-disease
#16
Katarzyna Kuter, Manuela Kratochwil, Sven-Hendric Marx, Sonja Hartwig, Stephan Lehr, Michiru D Sugawa, Norbert A Dencher
Cause of Parkinson's disease (PD) is still not understood. Motor symptoms are not observed at early stages of disease due to compensatory processes. Dysfunction of mitochondria was indicated already at preclinical PD. Selective toxin 6-OHDA was applied to kill dopaminergic neurons in substantia nigra and disturb neuronal transmission in striatum. Early phase of active degeneration and later stage, when surviving cells adapted to function normally, were analysed. 2D BN/SDS difference gel electrophoresis (DIGE) of mitochondrial proteome enabled to point out crucial processes involved at both time-points in dopaminergic structures...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27373781/untargeted-mass-spectrometric-approach-in-metabolic-healthy-offspring-of-patients-with-type-2-diabetes-reveals-medium-chain-acylcarnitine-as-potential-biomarker-for-lipid-induced-glucose-intolerance-lgit
#17
Birgit Knebel, Susanne Mack, Stefan Lehr, Aiko Barsch, Martina Schiller, Jutta Haas, Simone Lange, Jens Fuchser, Gabriela Zurek, Dirk Müller-Wieland, Jorg Kotzka
Offspring of type 2 diabetes (T2D) patients have increased risk to develop diabetes, due to inherited genetic susceptibility that directly interferes with the individual adaption to environmental conditions. We characterise T2D offspring (OSP) to identify metabolic risk markers for early disease prediction. Plasma of metabolically healthy OSP individuals (n = 43) was investigated after an oral lipid tolerance test (oLTT) by an untargeted mass spectrometric approach for holistic metabolome analyses. Two subgroups of OSP probands can be separated by oLTT, although not differing in general clinical parameters...
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27089245/2d-gel-based-proteomics-there-s-life-in-the-old-dog-yet
#18
Reiner Westermeier
In the nowadays mainly mass spectrometry-driven world of Proteomics, one can frequently read and hear that 2D gel-based electrophoresis methods are no longer used for proteome analysis. This short review is a compilation of facts why the gel-based workflow is not dead.
December 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27710142/corrigendum
#19
(no author information available yet)
No abstract text is available yet for this article.
October 6, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27477619/insulin-sensitivity-body-composition-and-adipose-depots-following-12-w-combined-endurance-and-strength-training-in-dysglycemic-and-normoglycemic-sedentary-men
#20
Torgrim Mikal Langleite, Jørgen Jensen, Frode Norheim, Hanne Løvdal Gulseth, Daniel Steensen Tangen, Kristoffer Jensen Kolnes, Ansgar Heck, Tryggve Storås, Guro Grøthe, Marius Adler Dahl, Anders Kielland, Torgeir Holen, Hans Jørgen Noreng, Hans Kristian Stadheim, Atle Bjørnerud, Egil Ivar Johansen, Birgitte Nellemann, Kåre Inge Birkeland, Christian A Drevon
CONTEXT: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. OBJECTIVE: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia. MATERIAL AND METHODS: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise...
October 2016: Archives of Physiology and Biochemistry
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