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Archives of Physiology and Biochemistry

Olufunto O Badmus, Lawrence A Olatunji
OBJECTIVE: We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory biomarkers, which are dipeptidyl peptidase-4 (DPP-4)- and glycogen synthase kinase-3 (GSK-3)-dependent. METHODS: Female Wistar rats received vehicle (control; n = 6) or GC (dexamethasone; n = 6; 0.2 mg/kg; p.o.) for six days. Insulin resistance was determined by HOMA-IR. DPP-4 activity was determined by fluorescence method, whereas vascular cell adhesion molecule-1 (VCAM-1), uric acid, malondialdehyde (MDA), lactate dehydrogenase (LDH) and nitric oxide (NO) from plasma and cardiac homogenate were estimated as cardiac pro-inflammatory biomarkers...
June 18, 2018: Archives of Physiology and Biochemistry
Saira Yasmeen, Unab Khan, Ghulam Mustafa Khan, Syeda Sadia Fatima
The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. High TIMP2 was seen in MetS group (145.28 ± 23.11 pg/ml) versus controls (19.06 ± 1.19 pg/ml; p < .001). Serum cholesterol, triglyceride, LDL-c and glucose levels were significantly higher in MetS subjects (p < ...
June 18, 2018: Archives of Physiology and Biochemistry
Khaled Hamden, Mohamed Ali Boujibiha, Nouha Ben Abdeljelil, Manel Njima, Boulbaba Selmi, Lotfi Achour
OBJECTIVE: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity. METHODS: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD). RESULTS: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity by 34%, decreased body weight by 20% and modulated lipid profile, showed a decrease in total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma by 59% and 42%, respectively, and increased the HDL-cholesterol (HDL-C) level by 31%...
June 14, 2018: Archives of Physiology and Biochemistry
Fatma Ghorbel Koubaa, Raed Abdennabi, Ahlem Soussi Ben Salah, Abdelfattah El Feki
In this study, we assess the impact of Salvia officinalis essential oil on renal toxicity induced by vanadium in rats. The animals were exposed to either ammonium metavanadate (5 mg/kg body weight) or the combination of vanadium and S. officinalis essential oil (15 mg EO/kg body weight) for 10 days. Vanadium induced significant renal damage, demonstrated by increased plasma levels of urea and creatinine. A marked increase in lipid peroxidation markers and carbonyl protein levels with a significant decrease in enzymatic antioxidants (SOD), catalase (CAT), and glutathione peroxidase (GPx) was also observed in vanadium-treated rats...
June 8, 2018: Archives of Physiology and Biochemistry
Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Mohammad Hassan Javanbakht, Abbas Mirshafiey
This research aimed to evaluate the anti-diabetic effects of β-d-mannuronic acid (M2000) on blood glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats. Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p < .05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p < ...
June 8, 2018: Archives of Physiology and Biochemistry
Antoaneta Gateva, Yavor Assyov, Tsvetan Gatev, Zdravko Kamenov
AIM: The aim of the present study was to investigate the prevalence of macrovascular complications across different carbohydrate disturbances. PATIENTS AND METHODS: In the study, we included 167 patients, divided them into three age and BMI matched groups - group 1 with obesity without carbohydrate disturbances (n = 66), group 2 with prediabetes (n = 68) and group 3 with newly diagnosed type 2 diabetes (n = 33). Endothelial function was evaluated using EndoPAT, intima media thickness (IMT) was measured on the common carotid artery and ankle-brachial index (ABI) was calculated...
June 8, 2018: Archives of Physiology and Biochemistry
Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, İlker Yavaş, Şule Yurdagül Özsoy
In this study, we have investigated the effects of different doses of thymol (T) and carvacrol (C) on sperm quality oxidative stress and antioxidant system. For this purpose, 49 rats were divided into seven groups (7 rats in each group): 1st Group (control); 2nd Group T-10 (thymol 10 mg/kg), 3rd Group T-20 (thymol 20 mg/kg), 4th Group C-10 (carvacrol 10 mg/kg), 5th Group C-20 (carvacrol 20 mg/kg), 6th Group T + C-10 (thymol 10 mg/kg + carvacrol 10 mg/kg) and 7th Group T + C-20 (thymol 20 mg/kg + carvacrol 20 mg/kg)...
May 25, 2018: Archives of Physiology and Biochemistry
Asmaa Mohammed Shamseldeen, Mohammed Ali Eshra, Laila Ahmed Rashed, Marwa Fathy Amer, Amal Elham Fares, Samaa Samir Kamar
CONTEXT: Maternal diet composition could influence fetal organogenesis. OBJECTIVE: We investigated effects of high fat diet (HFD) intake alone or combined with omega 3 during pregnancy, lactation and early days of weaning on nephrogenesis of pups and maternal renal function and morphology. MATERIAL AND METHODS: Mothers and their pups included in each group were supplied with the same diet composition. Rats were divided into group I, II and III supplied with chow of either 10 kcal%, 45 kcal% or 45 kcal% from fat together with omega-3 respectively...
May 9, 2018: Archives of Physiology and Biochemistry
Zuhal Alım, Deryanur Kılıç, Yeliz Demir
BACKGROUND: Paraoxonase 1 (PON1: EC is a vital antioxidant enzyme against mainly atherosclerosis and many other diseases associated with oxidative stress. Thus, studies related to PON1 have an important place in the pharmacology. In this study, we aimed to evaluate the in vitro inhibition effects of some indazoles on the activity of human PON1. METHODS: PON1 was purified from human serum with a specific activity of 5000 U/mg and 13.50% yield by using simple chromatographic methods...
May 9, 2018: Archives of Physiology and Biochemistry
Shereen Mohamed Galal, Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed El Kiki
The present study was designed to evaluate the effect of cranberry extract (CRAN) and/or losartan (LOS) against aluminium chloride (AlCl3 ) induced hepatorenal damage associated cardiomyopathy in rats. To induce hepatorenal and cardiotoxicity, animals were received (AlCl3 ; 70 mg/kg i.p.) for 8 weeks day after day and treated with CRAN (100 mg/kg b.wt.) orally daily for 4 weeks started after 4 weeks from AlCl3 injection accompanied with an administration of LOS (5 mg/kg i.p.) three times weekly for 4 weeks...
April 23, 2018: Archives of Physiology and Biochemistry
Ahmet Mor, Yildirim Kayacan, Gokhan Ipekoglu, Erkal Arslanoglu
OBJECTIVE: This study aimed to examine the effect of CHO-E consumption after high-intensity exercise on insulin, cortisol hormones and blood glucose responses, which is important for performance and recovery in athletes. METHODS: Sixteen volunteers, male athletes, participated into this study. Athletes were divided into two groups as experiment (CHO-E) and placebo (PLA). Blood was taken from the athletes three times as basal, post-exercise (PE) and 2 h after ingestion of supplement (PS)...
April 21, 2018: Archives of Physiology and Biochemistry
Osman Sinan Ozsezen, Ismail Meral
OBJECTIVE: Type I diabetes is a disease characterised by an extreme reduction in serum insulin levels. Diet and exercise have gained considerable attention in the treatment of diabetes. Therefore, this study was carried out to investigate the effect of diet with carbohydrate but without daily energy restriction on various metabolites (glucose, triglycerides, cholesterol, lactate), some electrolytes (Ca, Mg, Na, K, P, Cl) and essential metals (Mn, Co, Cu, Se, Zn, Fe) in the blood of rats with streptozotocin-induced diabetes...
April 21, 2018: Archives of Physiology and Biochemistry
Firoz Anwar, Ruqaiyah Khan, Richa Sachan, Imran Kazmi, Alisha Rawat, Abdullah Sabih, Rajbala Singh, Muhammad Afzal, Aftab Ahmad, Abdulaziz S Al-Orab, F A Al-Abbasi, Prakash Chandra Bhatt, Vikas Kumar
HCC has been reported to be immensely occurring carcinoma worldwide. Recent days the mortality occurred due to liver cancer has also been found to be increased at an alarming speed affecting mostly the young patients. The aim of the current study was to decipher the role of calcium and vitamin K3 in the treatment of chemically induced hepatocarcinogenesis in the male Wistar rats. Liver cancer was induced via a subnecrogenic dose of 160 mg/kg body weight, diethylnitrosamine (DENA) when associated with fasting/refeeding in male Wistar rats...
April 17, 2018: Archives of Physiology and Biochemistry
Anis Ben Hsouna, Manel Gargouri, Wissal Dhifi, Walid Saibi
The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4 ) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Administration of a single dose of CCl4 caused hepatoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) and in protein carbonyl level but a decrease in antioxidant markers in the liver tissue...
April 17, 2018: Archives of Physiology and Biochemistry
Fanwei Meng
CONTEXT: Renal ischaemia reperfusion (I/R) is a common clinical condition with a high morbidity and mortality rate. To date, I/R-induced renal injury remains an ineffective treatment. OBJECTIVE: We hypothesis that angiogenesis and lymphangiogenesis markers, prospero homeobox-1 (PROX-1) and lymphatic endothelial hyaluronan receptor-1 (LYVE-1), are critical during I/R. MATERIAL AND METHODS: Kunming mice were subjected to I/R and observed for the following eight consecutive days...
April 10, 2018: Archives of Physiology and Biochemistry
Naif M Alhawiti, Sultan A Alqahtani
This study investigated the effects of chronic supraphysiological dose of testosterone propionate administration cardiovascular function in rats from the perspective of haemostatic function including platelet functions, coagulation, and fibrinolysis. Testosterone significantly enhanced cardiac contractility by enhancing LVSP (10%), dp/dtmax (36.7%), dp/dtmin (14.6%) without altering heart rate, diastolic function, and serum lipid profile. While it has no effect on platelets count, thromboxane B2 levels, and platelet aggregation, testosterone significantly enhanced bleeding time and increased circulatory and thoracic aorta mRNA and protein levels of tPA (46...
April 4, 2018: Archives of Physiology and Biochemistry
Flavia Hosaki Silvino da Silva, Maisa Pavani Dos Santos, Mayara Peron Pereira, Samyra Lopes Buzelle, Edgar Wilibaldo Allebrandt Neto, Bibiana Mozzaquatro Gai, Francyele Dos Santos Correia, Cristina Helena Alves, Suelem Aparecida de França, Nair Honda Kawashita
The aim of this study was to evaluate the generation of reactive oxygen species (ROS) by xanthine oxidase (XO), the enzymatic antioxidant system and oxidative damage in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity by 45% and the activities of glutathione peroxidase (GPx), glutathione reductase and catalase in the soleus muscles. There was an increase in the carbonylated proteins with no increase thiobarbituric acid reactive substances (TBARS), although the XO activity had increased 20%...
March 29, 2018: Archives of Physiology and Biochemistry
S H Priyanka, S Syam Das, Saritha S Nair, Arun A Rauf, M Indira
CONTEXT: Our previous studies showed that all trans retinoic acid (ATRA) ameliorates alcohol-induced toxicity. Hence, we evaluated the efficacy of ATRA and abstention in the regression of alcohol-induced hepatotoxicity. MATERIALS AND METHODS: After ethanol administration to rats for 90 days, the regression of alcohol-induced toxicity was studied by supplementing ATRA at a dose of 100 μg/kg body weight for 30 days. It was also compared with animals in abstention...
March 28, 2018: Archives of Physiology and Biochemistry
Hadi Bamehr, Massoud Saidijam, Dara Dastan, Razieh Amini, Mona Pourjafar, Rezvan Najafi
Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of methanolic extract of F. pseudalliacea against human colon cancer HCT-116 cell line. Cytotoxic effects of F. pseudalliacea on HCT-116 cells was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Real-time polymerase chain reaction (PCR) and Western blot were employed to analyze BAX and Bcl2 expression. Cell cycle analysis and apoptosis were conducted using flowcytometry and Annexin V/ propidium iodide (PI) staining...
March 27, 2018: Archives of Physiology and Biochemistry
Samaneh Mortazaei, Hedayat Sahraei, Zahra Bahari, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Boshra Hatef
CONTEXT: The involvement of unilateral and bilateral inhibition of the ventral tegmental area (VTA) in response to stress is not well understood. OBJECTIVE: In the present study, the effect of unilateral and bilateral inhibition of the VTA on hormonal, metabolic, and locomotor responses to stress was assessed. MATERIAL AND METHODS: Male rats seven days after cannulation into the VTA received electro foot-shock stress for seven consecutive days...
March 26, 2018: Archives of Physiology and Biochemistry
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