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Archives of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/30081678/astaxanthin-alleviates-renal-damage-of-rats-on-high-fructose-diet-through-modulating-nf%C3%AE%C2%BAb-sirt1-pathway-and-mitigating-oxidative-stress
#1
Hatice Iskender, Guler Yenice, Eda Dokumacioglu, Armagan Hayirli, Cigdem Sevim, Ali Dokumacioglu, Kubra Asena Terim Kapakin
This study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation of renal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 × 2 factorial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within 0.2 ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreased serum urea (p < .01) and blood urea-N concentrations (p < .02) at a lower extent in rats receiving fructose than those not receiving fructose...
August 6, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30081677/cardiorespiratory-fitness-and-the-relationship-between-body-fat-and-resting-testosterone-in-men
#2
Peter A Hosick, Evan L Matthews, Steven Leigh
OBJECTIVE: To examine the effect of cardiovascular fitness, i.e. VO2 max, on the relationship between weight status and resting testosterone level (RTL) in males. MATERIALS AND METHODS: A subset of male participants from the 2003-2004 National Health and Nutrition Examination Survey were analyzed by weight status, i.e. normal, overweight, obese, and all participants. Bivariate correlation coefficients were computed for RTL, percent body fat (BF%), and VO2 max. Partial correlation coefficients were computed between RTL and BF% controlling for VO2 max and between RTL and VO2 max controlling for BF%...
August 6, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30039987/endoplasmic-reticulum-stress-in-the-livers-of-bdnf-heterozygous-knockout-mice
#3
Selma Cırrık, Gulay Hacioglu, İsmail Abidin, Selcen Aydın-Abidin, Tevfik Noyan
CONTEXT: Involvement of endoplasmic reticulum (ER) stress and brain-derived neurotrophic factor (BDNF) in hepatic lipid metabolism has been reported previously. OBJECTIVE: The effects of chronic BDNF deficiency on ER stress response in the livers were examined in this study. METHODS: BDNF(+/-) mice, characterised by BDNF deficiency, and their wild-type (WT) littermates were used. The ER stress was induced by tunicamycin (Tm) (0.5 mg/kg, intraperitoneal)...
July 24, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30032657/iron-hypothesis-and-coronary-artery-disease-in-geriatric-patients
#4
Hossein Mokhtari, Babak Bagheri, Mehdi Rasouli
Context and aims: Iron is a pro-oxidant factor in the pathogenesis of CAD. The association of body iron status was investigated relative to the occurrence and severity of CAD. DESIGN AND METHODS: The subjects consisted of 110 males and 115 females who were classified as either a CAD case or a control according to the results of coronary angiography. RESULTS: A new parameter, the "serum free iron index," was defined as the ratio of serum iron to UIBC. The level of ferritin showed significant increase [97...
July 21, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30032654/matrix-metalloproteinase-activities-and-oxidative-stress-in-newborn-cardiac-tissue-of-rabbit-female-fed-high-cholesterol-methionine-diet
#5
Sarah Ait-Benali, Khira Othmani-Mecif, Yasmina Benazzoug
We study the effect of an enriched cholesterol-methionine diet administered to females on the cardiac tissue remodelling of the offspring during two successive pregnancies. Two groups are constituted, standard diet (SD) group fed a standard diet and CD group fed a combined diet (standard + cholesterol 1%-methionine 0.25%). The diet is administered during 80 days. The results show changes in serum and cardiac parameters of CD newborn, with the involvement of phospholipids (PLs) (phosphatidylethanolamine (PE) and phosphatidylcholine (PC), variations in malondialdehyde (MDA), conjugated diene (CD), and vitamin C [VIT-C] rates)...
July 21, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29950115/swim-training-affects-bone-canonical-wnt-pathway-in-type-2-diabetes-induced-by-high-fat-diet-and-low-dose-of-streptozotocin-in-male-rats
#6
Laleh Pezhman, Farzam Sheikhzadeh Hesari, Rafighe Ghiasi, Mohammad Reza Alipour
OBJECTIVE: Susceptibility to diabetes-induced bone complication has been linked to Wnt signaling, which plays an important role in bone development and remodeling. In this study, the effect of swim training on Wnt pathway in T2DM was investigated. MATERIALS AND METHODS: Forty male rats were assigned to groups: control (C), diabetic (D), exercised control (E) and diabetic exercised (DE). One week after the induction of diabetes, animals were subjected to swim. At the end of training, bone gene and protein levels of SOST, RUNX2 and RANKL/OPG ratio were measured...
June 27, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29925282/amoxicillin-and-gentamicin-antibiotics-treatment-adversely-influence-the-fertility-and-morphology-through-decreasing-the-dazl-gene-expression-level-and-increasing-the-oxidative-stress
#7
Muhammet Karaman, Harun Budak, Mehmet Çiftci
The present study was designed to explain the impact of amoxicillin, gentamicin, and cefazolin on the oxidative stress (OS) and reproductivity in the mouse testes. Our data showed that reduced glutathione (GSH) level, which is a marker for OS, strikingly reduced and hydrogen peroxide (H2 O2 ) level, which acts as a signaling molecule in mammalian germ cells, strikingly increased with amoxicillin, gentamicin, and cefazolin treatment. The gene expression and enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), and glutathione-S-transferases (GST) were significantly affected in the presence of these antibiotics...
June 20, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29925280/role-of-some-circulating-mirnas-on-breast-cancer-diagnosis
#8
Menha Swellam, Rasha F K Zahran, Hossam Abo El-Sadat Taha, Nashwa El-Khazragy, Camelia Abdel-Malak
Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids of cancer patients. Authors aimed to investigate the diagnostic role of miRNA-17-5p, miR-155 and miRNA-222 in serum samples from breast cancer patients (n = 80), benign breast patients (n = 40) and healthy individuals (n = 30) using quantitative real-time PCR technique. Median levels of investigated markers revealed significant increase in primary breast cancer followed by benign and control groups...
June 20, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29912577/glucocorticoid-exposure-causes-disrupted-glucoregulation-cardiac-inflammation-and-elevated-dipeptidyl-peptidase-4-activity-independent-of-glycogen-synthase-kinase-3-in-female-rats
#9
Olufunto O Badmus, Lawrence A Olatunji
OBJECTIVE: We tested the hypothesis that glucocorticoid (GC) exposure in female rats would lead to glucose dysregulation and elevated cardiac inflammatory biomarkers, which are dipeptidyl peptidase-4 (DPP-4)- and glycogen synthase kinase-3 (GSK-3)-dependent. METHODS: Female Wistar rats received vehicle (control; n = 6) or GC (dexamethasone; n = 6; 0.2 mg/kg; p.o.) for six days. Insulin resistance was determined by HOMA-IR. DPP-4 activity was determined by fluorescence method, whereas vascular cell adhesion molecule-1 (VCAM-1), uric acid, malondialdehyde (MDA), lactate dehydrogenase (LDH) and nitric oxide (NO) from plasma and cardiac homogenate were estimated as cardiac pro-inflammatory biomarkers...
June 18, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29912573/association-of-tissue-inhibitor-of-metalloproteinase-2-with-non-alcoholic-fatty-liver-disease-in-metabolic-syndrome
#10
Saira Yasmeen, Unab Khan, Ghulam Mustafa Khan, Syeda Sadia Fatima
The aim of this case-control study was to assess TIMP2 level in subjects with or without metabolic syndrome (MetS) and to associate levels with non-alcoholic fatty liver changes (NAFLD). Thirty-three MetS subjects and 55 controls were recruited. Anthropometric data, lipid and glucose profile, TIMP2 and liver ultrasound was performed. High TIMP2 was seen in MetS group (145.28 ± 23.11 pg/ml) versus controls (19.06 ± 1.19 pg/ml; p < .001). Serum cholesterol, triglyceride, LDL-c and glucose levels were significantly higher in MetS subjects (p < ...
June 18, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29898610/phytoestrogens-inhibit-key-enzymes-linked-to-obesity-type-2-diabetes-and-liver-kidney-toxicity-in-high-fructose-fat-diet-in-mice
#11
Khaled Hamden, Mohamed Ali Boujibiha, Nouha Ben Abdeljelil, Manel Njima, Boulbaba Selmi, Lotfi Achour
OBJECTIVE: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity. METHODS: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD). RESULTS: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity by 34%, decreased body weight by 20% and modulated lipid profile, showed a decrease in total-cholesterol (TC) and LDL-cholesterol (LDL-C) rates in the plasma by 59% and 42%, respectively, and increased the HDL-cholesterol (HDL-C) level by 31%...
June 14, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29884068/microwave-extraction-of-salvia-officinalis-essential-oil-and-assessment-of-its-gc-ms-identification-and-protective-effects-versus-vanadium-induced-nephrotoxicity-in-wistar-rats-models
#12
Fatma Ghorbel Koubaa, Raed Abdennabi, Ahlem Soussi Ben Salah, Abdelfattah El Feki
In this study, we assess the impact of Salvia officinalis essential oil on renal toxicity induced by vanadium in rats. The animals were exposed to either ammonium metavanadate (5 mg/kg body weight) or the combination of vanadium and S. officinalis essential oil (15 mg EO/kg body weight) for 10 days. Vanadium induced significant renal damage, demonstrated by increased plasma levels of urea and creatinine. A marked increase in lipid peroxidation markers and carbonyl protein levels with a significant decrease in enzymatic antioxidants (SOD), catalase (CAT), and glutathione peroxidase (GPx) was also observed in vanadium-treated rats...
June 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29882437/anti-diabetic-effect-of-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-nsaid-with-immunosuppressive-property-on-insulin-production-blood-glucose-and-inflammatory-markers-in-the-experimental-diabetes-model
#13
Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Mohammad Hassan Javanbakht, Abbas Mirshafiey
This research aimed to evaluate the anti-diabetic effects of β-d-mannuronic acid (M2000) on blood glucose, insulin production, and inflammatory markers in streptozotocin-induced diabetic rats. Our data showed that the final fasting serum glucose level was significantly lower in the M2000-treated group compared to the diabetic control group (p < .05). In addition, the final fasting serum insulin level significantly increased in the M2000-treated group compared to the diabetic control group (p < ...
June 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29882429/endothelial-dysfunction-and-intima-media-thickness-are-selectively-related-to-the-different-carbohydrate-disturbances-across-the-glucose-continuum
#14
Antoaneta Gateva, Yavor Assyov, Tsvetan Gatev, Zdravko Kamenov
AIM: The aim of the present study was to investigate the prevalence of macrovascular complications across different carbohydrate disturbances. PATIENTS AND METHODS: In the study, we included 167 patients, divided them into three age and BMI matched groups - group 1 with obesity without carbohydrate disturbances (n = 66), group 2 with prediabetes (n = 68) and group 3 with newly diagnosed type 2 diabetes (n = 33). Endothelial function was evaluated using EndoPAT, intima media thickness (IMT) was measured on the common carotid artery and ankle-brachial index (ABI) was calculated...
June 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29799283/effects-of-thymol-and-carvacrol-on-sperm-quality-and-oxidant-antioxidant-balance-in-rats
#15
Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, İlker Yavaş, Şule Yurdagül Özsoy
In this study, we have investigated the effects of different doses of thymol (T) and carvacrol (C) on sperm quality oxidative stress and antioxidant system. For this purpose, 49 rats were divided into seven groups (7 rats in each group): 1st Group (control); 2nd Group T-10 (thymol 10 mg/kg), 3rd Group T-20 (thymol 20 mg/kg), 4th Group C-10 (carvacrol 10 mg/kg), 5th Group C-20 (carvacrol 20 mg/kg), 6th Group T + C-10 (thymol 10 mg/kg + carvacrol 10 mg/kg) and 7th Group T + C-20 (thymol 20 mg/kg + carvacrol 20 mg/kg)...
May 25, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29156993/phenolic-compounds-analysis-antioxidant-and-hepatoprotective-effects-of-periploca-angustifolia-extract-on-cadmium-induced-oxidative-damage-in-hepg2-cell-line-and-rats
#16
Khaled Athmouni, Dalel Belhaj, Khaoula Mkadmini Hammi, Abdelfattah El Feki, Habib Ayadi
A total of five components (Catechin, Caffeic acid, Ferulic acid, Rosmarinic acid, and Amentoflavone) were identified in Periploca angustifolia leaf methanolic extract. This extract did not cause any cytotoxic effect on HepG2 cell line within the range of concentrations tested (0-400 µg mL-1 ). Thus, pre-treatment with 100 µg mL-1 of P. angustifolia leaf methanolic extract (PAE) significantly (p < .05) protective HepG2 cells against cytotoxicity induced by cadmium exposure. However, Cd-intoxication significantly (p < ...
July 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29108440/cardiopreventive-effects-of-camel-milk-against-carbon-tetrachloride-induced-oxidative-stress-biochemical-and-histological-alterations-in-mice
#17
Houda Hamed, Manel Gargouri, Khaled Bellassoued, Zied Ghannoudi, Abdelfattah Elfeki, Ahmed Gargouri
The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4 ) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CCl4 caused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities...
July 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29105496/a-helicobacter-pylori-associated-insulin-resistance-in-asymptomatic-sedentary-young-men-does-not-correlate-with-inflammatory-markers-and-urine-levels-of-8-iso-pgf-2-%C3%AE-or-1-4-dihydroxynonane-mercapturic-acid
#18
Andriy Cherkas, Sergii Golota, Françoise Guéraud, Orest Abrahamovych, Christoph Pichler, Armen Nersesyan, Volodymyr Krupak, Vira Bugiichyk, Ostap Yatskevych, Mykhaylo Pliatsko, Peter Eckl, Siegfried Knasmüller
A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. pylori negative and 12 positive) and measured whole blood glucose, glycated haemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, TNF-alpha and comet assay...
July 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29072102/zinc-and-selenium-modulate-barium-induced-oxidative-stress-cellular-injury-and-membrane-bound-atpase-in-the-cerebellum-of-adult-rats-and-their-offspring-during-late-pregnancy-and-early-postnatal-periods
#19
Awatef Elwej, Imen Ghorbel, Mariem Chaabane, Nejla Soudani, Hela Mnif, Tahia Boudawara, Najiba Zeghal, Madiha Sefi
CONTEXT: Barium (Ba) may induce oxidative stress leading to tissues injury. OBJECTIVE: Our study investigated the therapeutic efficiency of zinc (Zn) and selenium (Se) against neurotoxicity induced by Ba in adult rats and their progeny. MATERIAL AND METHODS: Pregnant rats are exposed either to Ba (67 ppm), Ba + Zn, Ba + S or to only Zn and Se. RESULTS: In Ba-treated rats, there was an increase of MDA, H2 O2 , AOPP levels and SOD activity in the cerebellum of dams and their pups, a decrease in GPx, CAT, AChE, Na+ K+ -ATPase and Mg2+ -ATPase activities, GSH and NPSH levels...
July 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29072101/understanding-mitochondrial-biogenesis-through-energy-sensing-pathways-and-its-translation-in-cardio-metabolic-health
#20
Abhijit Nirwane, Anuradha Majumdar
Mitochondria play a pivotal role in physiological energy governance. Mitochondrial biogenesis comprises growth and division of pre-existing mitochondria, triggered by environmental stressors such as endurance exercise, caloric restriction, cold exposure and oxidative stress. For normal physiology, balance between energy intake, storage and expenditure is of utmost important for the coordinated regulation of energy homeostasis. In contrast, abnormalities in these regulations render the individual susceptible to cardiometabolic disorders...
July 2018: Archives of Physiology and Biochemistry
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