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Archives of Physiology and Biochemistry

Soheyla Khakdan, Maryam Delfan, Maryam Heydarpour Meymeh, Faranak Kazerouni, Hamid Ghaedi, Mehrnoosh Shanaki, Fatemeh Kalaki-Jouybari, Sattar Gorgani-Firuzjaee, Ali Rahimipour
AIMS: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard. METHODS: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT)...
October 15, 2018: Archives of Physiology and Biochemistry
Mohamed Darwesh Morsy
This study investigated the effect of acylated ghrelin (AG) deficiency after sleeve gastrectomy (SG) or chronic administration in control and SG-indiuced rats on platelet function, coagulation, and fibrinolysis. Administration of AG (100 µg/kg, subcutaneously) to control or SG rats significantly inhibited platelets aggregation and lowered levels of Von-Willebrand factor (vWF), fibrinogen, and thromboxane B2. Concomitantly, it decreased circulatory levels and aortic expression levels of plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) and increased the aortic expression of the endothelial nitric oxidase (eNOS)...
October 15, 2018: Archives of Physiology and Biochemistry
Seul Ah Lee, Bo-Ram Park, Sung-Min Moon, Seul Hee Han, Chun Sung Kim
This study evaluated the anti-inflammatory potential of a 40% prethanol extract of Trifolium pratense leaves (40% PeTP) using in vitro (RAW264.7 cells) and in vivo (carrageenan-induced inflammation model) experiments. Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in RAW264...
October 15, 2018: Archives of Physiology and Biochemistry
Fatemeh Kalaki-Jouybari, Mehrnoosh Shanaki, Maryam Delfan, Sattar Gorgani-Firouzjae, Soheyla Khakdan
BACKGROUND: Exercise intervention is strongly recommended to manage metabolic diseases. In this study, we investigate, whether HIIT and CET can induce hepatic miR-122 expression, NAFLD rats with diabetes. METHODS: 40 Wistar rats divided into 2 groups, non-diabetic (NDC) and diabetic .Type 2 diabetes was induced by high-fat high-fructose diet (HFHFD). Then diabetic rats were subdivided into three groups: diabetic control (HFHFD + DC), CET (HFHFD + CET), and HIIT (HFHFD + HIIT)...
October 13, 2018: Archives of Physiology and Biochemistry
O A Adeyanju, O S Michael, A O Soladoye, L A Olatunji
CONTEXT: Estrogen-progestin combined oral contraceptive (COC) has been connected to mineralocorticoid receptor (MR) activation and adverse cardiometabolic events. We consequently hypothesised that insulin resistance (IR), hyperuricemia, and elevated circulating GSK-3 induced by COC is through activation of MR via mineralocorticoid and glucocorticoid pathways. METHODS: Female Wistar rats aged 12 weeks received (po) vehicle and COC (1.0 μg ethinylestradiol plus 5...
October 13, 2018: Archives of Physiology and Biochemistry
Doddappa Mallappa Bannigida, Shivananda B Nayak, Vijayaragavan R
AIM: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility. Adipose tissue releases various adipokines, including visfatin and adiponectin, which have influence on insulin resistance (IR). OBJECTIVE: To determine serum insulin levels, IR, serum visfatin and adiponectin levels in PCOS subjects. MATERIALS AND METHODS: Case-control study on 100 diagnosed PCOS patients (50 obese and 50 non-obese) and 100 control subjects (50 obese and 50 non obese)...
October 13, 2018: Archives of Physiology and Biochemistry
Romi Dasgupta, Indraneel Saha, Prajna Paramita Ray, Aniruddha Maity, Debajoyti Pradhan, Hari Prasad Sarkar, B R Maiti
Arecoline has biomedical importance, but it has untoward side effects on endocrine functions. The aim is to investigate its role on adrenal activity under thermal stress by ultrastructural and hormonal parameters in mice. Cold (4 °C) or heat (37 °C) stress, or arecoline (10 mg/kg body wt), each for 7 days in cold or heat stress stimulated adrenocortical activity ultrastructurally with an elevation of corticosterone level. Adrenomedullary activity was suppressed in cold stress with depletion of catecholamine levels...
October 13, 2018: Archives of Physiology and Biochemistry
Xiaohui Ma, Sitong Liu, Dongxue Liu, Qian Wang, Hongwei Li, Zhen Zhao
This study was to examine the role of exercise intervention in modulating neuropathic pain induced by diabetes. Diabetes was induced by streptozotocin (STZ, i.p.) in rats and mechanical hyperalgesia was observed three weeks after STZ. Mechanical withdrawal thresholds were increased after four to five weeks of exercise in STZ rats. We also examined the role of signal of mammalian target of rapamycin (mTOR) in regulating neuropathic pain. Inhibition of neuropathic pain by exercise in STZ rats was accompanied with decreases of p-mTOR, p-S6K1, and p-4E-BP1 in sensory nerves...
October 13, 2018: Archives of Physiology and Biochemistry
Fei Hu, Xiaohui Qiu, Shizhong Bu
Islet dysfunction is a hallmark of type 2 diabetes mellitus (T2DM). Compelling evidence suggests that accumulation of islet amyloid in the islets of Langerhans significantly contribute to β-cell dysfunction and diabetes. Emerging evidence implicates a role for cystic fibrosis transmembrane-conductance regulator in the regulation of insulin secretion from pancreatic islets. Impaired first-phase insulin responses and glucose homeostasis have also been reported in cystic fibrosis patients. The transforming growth factor-β protein superfamily is central regulators of pancreatic cell function, and has a key role in pancreas development and pancreatic disease, including diabetes and islet dysfunction...
October 6, 2018: Archives of Physiology and Biochemistry
R A Ajala-Lawal, N O Aliyu, T O Ajiboye
This study investigated the influence of betulinic acid on high-fructose diet-induced metabolic syndrome in rats. Oral administration of betulinic acid significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, betulinic acid restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Betulinic acid-mediated upregulation of protein kinase B (Akt) and phosphoinositde-3 kinase (PI3K) anulled high-fructose diet mediated depletion...
October 5, 2018: Archives of Physiology and Biochemistry
Vandana Panda, Priyanka Shinde, Payal Dande
CONTEXT: Spinaciaoleracea (spinach) is abundant in antioxidant phytoconstituents, termed as the natural antioxidant mixture (NAO). OBJECTIVE: This study evaluates the anti-hyperlipidemicand anti-obesity effects of an antioxidant-rich extract of Spinaciaoleracea (NAOE) and aerobic exercise (AE) in rats fed with high fat diet (HFD). METHODS: Rats received NAOE (200 and 400 mg/kg), the standard drug orlistat (10 mg/kg), AE and NAOEAE (NAOE 400 mg/kg + AE) daily with HFD for 21 d...
September 29, 2018: Archives of Physiology and Biochemistry
Sahar M El Agaty, Asmaa Ibrahim Ahmed
OBJECTIVES: To assess the remote pancreatic injury following renal ischemia/reperfusion (I/R) and to evaluate the effect of pre-treatment with melatonin on pancreatic structure and functions. METHODS: 21 rats were divided equally into sham group, renal I/R group, and melatonin pre-treated renal I/R (Mel-I/R) group. RESULTS: Renal I/R significantly increased serum amylase, fasting glucose and decreased serum insulin in I/R versus sham group...
September 29, 2018: Archives of Physiology and Biochemistry
N P Gómez-Crisóstomo, E N De la Cruz-Hernández, E R Méndez Méndez, M F Hernández-Landero, J U Camacho Liévano, E Martínez-Abundis
The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity...
September 29, 2018: Archives of Physiology and Biochemistry
Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang, Bo Liu
Insulin resistance is caused by various environmental and genetic factors leading to a number of serious health issues. Due to its multifactorial origin, molecular characterization may provide better tools for its effective treatment. On molecular level, dysregulation of signaling pathway by insulin receptor substrates (IRSs) is one of the most common reasons of this disease. IRSs are regulated by >50 serine/threonine kinases, which may have positive or negative effects on insulin sensitivity. Among these serine/threonine kinases, PIM kinases have garnered much attention as they not only affect insulin sensitivity by phosphorylating IRSs directly and/or indirectly but also alter the activities of their downstream molecules like PI3K, AKT, and mTOR...
September 29, 2018: Archives of Physiology and Biochemistry
Manal S Fawzy, Baraah T Abu AlSel, Essam Al Ageeli, Saeed Awad Al-Qahtani, Mohamed M Abdel-Daim, Eman A Toraih
BACKGROUND: Circulating non-coding RNAs (ncRNAs) have been implicated in health and disease. This study aimed to evaluate the serum expression profile of microRNA-499a (miR-499a) and its selected bioinformatically predicted partner long-ncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) in diabetes-related end-stage renal disease (ESRD) patients and to correlate the expressions with the patients' clinicolaboratory data. SUBJECTS AND METHODS: Real-time quantitative polymerase chain reaction was applied in diabetics with and without ESRD (n = 90 for each)...
September 29, 2018: Archives of Physiology and Biochemistry
Daniella R B S Novi, Camila B Vidigal, Bruno V D Marques, Simone Forcato, Hiviny A Raquel, Dimas A M Zaia, Cássia T B V Zaia, Marli C Martins-Pinge, Daniela C C Gerardin, Graziela S Ceravolo
OBJECTIVE: The aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring. MATERIALS AND METHODS: Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL). RESULTS: At 75 days of life, male and female MET offspring presented similar blood pressure when compared with their CTR...
September 29, 2018: Archives of Physiology and Biochemistry
Amal A Aloud, Veeramani Chinnadurai, Govindasamy Chandramohan, Mohammed A Alsaif, Khalid S Al-Numair
Galangin is a natural compound with anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorating effect of streptozotocin (STZ)-induced glucose homeostasis has not yet been evaluated. Hence, this study was aimed at exploring the role of galangin in STZ-induced glucose homeostasis, glycolytic and gluconeogenic enzyme changes in rats. STZ-treated rats were characterised by increased plasma glucose and glycosylated haemoglobin and decreased plasma insulin and haemoglobin compared with the normal cage...
September 29, 2018: Archives of Physiology and Biochemistry
Clement Okraku Tettey, In-Jun Yang, Heung-Mook Shin
OBJECTIVE: The objective of this study was to investigate the pharmacological effect of Smilax china Linn. water extract (SCLWE) on vascular relaxation and its underlying biochemical mechanisms. METHODOLOGY: Isolated rat aortic rings were pre-constricted with phenylephrine (PE). This was followed by the cumulative addition of SCLWE. The effect of endothelial nitric oxide and PI3K/Akt on the SCLWE-induced vasodilation was investigated by the pretreatment of endothelium-intact aortic strips with or without NG -nitro-L-arginine methyl ester (L-NAME) or wortmanin before constriction with PE...
September 29, 2018: Archives of Physiology and Biochemistry
Walid Hamdy El-Tantawy, Abeer Temraz
Chronic hepatitis C virus (HCV) infection is a significant public health problem, with a worldwide prevalence of approximately 170 million. Current therapy for HCV infection includes the prolonged administration of a combination of ribavirin and PEGylated interferon-α, for over a decade. This regimen is expensive and often associated with a poor antiviral response and unwanted side effects. A highly effective combination treatment is likely required for the future management of HCV infections and entry inhibitors could play an important role...
September 29, 2018: Archives of Physiology and Biochemistry
Khaled Athmouni, Khaoula Mkadmini Hammi, Abdelfattah El Feki, Habib Ayadi
The natural flavonoid (catechin) has been shown to possess a multitude of pharmacological activities. However, oral administrated catechin (CT) failed to fulfil its therapeutic potential due to poor absorption and low bioavailability. Thus, is a pressing need to develop a new approach from to increase its intestinal absorption and improved bioavailability. In this work, we intended the increase the bioavailability of CT by preparing catechin-phospholipid complex (CT-PH) and evaluate the protective effect of CT-PH complex against cadmium caused liver injuries in rats...
September 29, 2018: Archives of Physiology and Biochemistry
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