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Archives of Physiology and Biochemistry

Shereen Mohamed Galal, Hesham Farouk Hasan, Mohamed Khairy Abdel-Rafei, Shereen Mohamed El Kiki
The present study was designed to evaluate the effect of cranberry extract (CRAN) and/or losartan (LOS) against aluminium chloride (AlCl3 ) induced hepatorenal damage associated cardiomyopathy in rats. To induce hepatorenal and cardiotoxicity, animals were received (AlCl3 ; 70 mg/kg i.p.) for 8 weeks day after day and treated with CRAN (100 mg/kg b.wt.) orally daily for 4 weeks started after 4 weeks from AlCl3 injection accompanied with an administration of LOS (5 mg/kg i.p.) three times weekly for 4 weeks...
April 23, 2018: Archives of Physiology and Biochemistry
Ahmet Mor, Yildirim Kayacan, Gokhan Ipekoglu, Erkal Arslanoglu
OBJECTIVE: This study aimed to examine the effect of CHO-E consumption after high-intensity exercise on insulin, cortisol hormones and blood glucose responses, which is important for performance and recovery in athletes. METHODS: Sixteen volunteers, male athletes, participated into this study. Athletes were divided into two groups as experiment (CHO-E) and placebo (PLA). Blood was taken from the athletes three times as basal, post-exercise (PE) and 2 h after ingestion of supplement (PS)...
April 21, 2018: Archives of Physiology and Biochemistry
Osman Sinan Ozsezen, Ismail Meral
OBJECTIVE: Type I diabetes is a disease characterised by an extreme reduction in serum insulin levels. Diet and exercise have gained considerable attention in the treatment of diabetes. Therefore, this study was carried out to investigate the effect of diet with carbohydrate but without daily energy restriction on various metabolites (glucose, triglycerides, cholesterol, lactate), some electrolytes (Ca, Mg, Na, K, P, Cl) and essential metals (Mn, Co, Cu, Se, Zn, Fe) in the blood of rats with streptozotocin-induced diabetes...
April 21, 2018: Archives of Physiology and Biochemistry
Firoz Anwar, Ruqaiyah Khan, Richa Sachan, Imran Kazmi, Alisha Rawat, Abdullah Sabih, Rajbala Singh, Muhammad Afzal, Aftab Ahmad, Abdulaziz S Al-Orab, F A Al-Abbasi, Prakash Chandra Bhatt, Vikas Kumar
HCC has been reported to be immensely occurring carcinoma worldwide. Recent days the mortality occurred due to liver cancer has also been found to be increased at an alarming speed affecting mostly the young patients. The aim of the current study was to decipher the role of calcium and vitamin K3 in the treatment of chemically induced hepatocarcinogenesis in the male Wistar rats. Liver cancer was induced via a subnecrogenic dose of 160 mg/kg body weight, diethylnitrosamine (DENA) when associated with fasting/refeeding in male Wistar rats...
April 17, 2018: Archives of Physiology and Biochemistry
Anis Ben Hsouna, Manel Gargouri, Wissal Dhifi, Walid Saibi
The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4 ) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Administration of a single dose of CCl4 caused hepatoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) and in protein carbonyl level but a decrease in antioxidant markers in the liver tissue...
April 17, 2018: Archives of Physiology and Biochemistry
Fanwei Meng
CONTEXT: Renal ischaemia reperfusion (I/R) is a common clinical condition with a high morbidity and mortality rate. To date, I/R-induced renal injury remains an ineffective treatment. OBJECTIVE: We hypothesis that angiogenesis and lymphangiogenesis markers, prospero homeobox-1 (PROX-1) and lymphatic endothelial hyaluronan receptor-1 (LYVE-1), are critical during I/R. MATERIAL AND METHODS: Kunming mice were subjected to I/R and observed for the following eight consecutive days...
April 10, 2018: Archives of Physiology and Biochemistry
Naif M Alhawiti, Sultan A Alqahtani
This study investigated the effects of chronic supraphysiological dose of testosterone propionate administration cardiovascular function in rats from the perspective of haemostatic function including platelet functions, coagulation, and fibrinolysis. Testosterone significantly enhanced cardiac contractility by enhancing LVSP (10%), dp/dtmax (36.7%), dp/dtmin (14.6%) without altering heart rate, diastolic function, and serum lipid profile. While it has no effect on platelets count, thromboxane B2 levels, and platelet aggregation, testosterone significantly enhanced bleeding time and increased circulatory and thoracic aorta mRNA and protein levels of tPA (46...
April 4, 2018: Archives of Physiology and Biochemistry
Flavia Hosaki Silvino da Silva, Maisa Pavani Dos Santos, Mayara Peron Pereira, Samyra Lopes Buzelle, Edgar Wilibaldo Allebrandt Neto, Bibiana Mozzaquatro Gai, Francyele Dos Santos Correia, Cristina Helena Alves, Suelem Aparecida de França, Nair Honda Kawashita
The aim of this study was to evaluate the generation of reactive oxygen species (ROS) by xanthine oxidase (XO), the enzymatic antioxidant system and oxidative damage in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity by 45% and the activities of glutathione peroxidase (GPx), glutathione reductase and catalase in the soleus muscles. There was an increase in the carbonylated proteins with no increase thiobarbituric acid reactive substances (TBARS), although the XO activity had increased 20%...
March 29, 2018: Archives of Physiology and Biochemistry
S H Priyanka, S Syam Das, Saritha S Nair, Arun A Rauf, M Indira
CONTEXT: Our previous studies showed that all trans retinoic acid (ATRA) ameliorates alcohol-induced toxicity. Hence, we evaluated the efficacy of ATRA and abstention in the regression of alcohol-induced hepatotoxicity. MATERIALS AND METHODS: After ethanol administration to rats for 90 days, the regression of alcohol-induced toxicity was studied by supplementing ATRA at a dose of 100 μg/kg body weight for 30 days. It was also compared with animals in abstention...
March 28, 2018: Archives of Physiology and Biochemistry
Hadi Bamehr, Massoud Saidijam, Dara Dastan, Razieh Amini, Mona Pourjafar, Rezvan Najafi
Ferula species have diverse biological functions. This study set out to investigate the anti-proliferative effects of methanolic extract of F. pseudalliacea against human colon cancer HCT-116 cell line. Cytotoxic effects of F. pseudalliacea on HCT-116 cells was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. Real-time polymerase chain reaction (PCR) and Western blot were employed to analyze BAX and Bcl2 expression. Cell cycle analysis and apoptosis were conducted using flowcytometry and Annexin V/ propidium iodide (PI) staining...
March 27, 2018: Archives of Physiology and Biochemistry
Samaneh Mortazaei, Hedayat Sahraei, Zahra Bahari, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Boshra Hatef
CONTEXT: The involvement of unilateral and bilateral inhibition of the ventral tegmental area (VTA) in response to stress is not well understood. OBJECTIVE: In the present study, the effect of unilateral and bilateral inhibition of the VTA on hormonal, metabolic, and locomotor responses to stress was assessed. MATERIAL AND METHODS: Male rats seven days after cannulation into the VTA received electro foot-shock stress for seven consecutive days...
March 26, 2018: Archives of Physiology and Biochemistry
Arleta Rifati Nixha, Adem Ergun, Nahit Gencer, Oktay Arslan, Mustafa Arslan
Polyphenol oxidase (Tyrosinase, PPO) has received considerable attention, since it is the key enzyme in melanin biosynthesis. In this study, we investigated prepared novel carbazole-containing pyridopyrimidine-substituted with urea and thiourea derivatives and their PPO activities on the diphenolase activity of banana tyrosinase. The structures of the compounds synthesized were confirmed by 1 H NMR, 13 C NMR, FTIR and elemental analysis. PPO enzyme was purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-amino benzoic acid...
March 23, 2018: Archives of Physiology and Biochemistry
Fikret Türkan, Zübeyir Huyut, Yeliz Demir, Fatma Ertaş, Şükrü Beydemir
BACKGROUND: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. SUBJECTS AND METHODS: The in vitro and in vivo effects of cefoperazone sodium (CFP), cefuroxime (CXM), and cefazolin (CZO) were investigated on GST and AChE activity in the present study. GST was purified using Glutathione-Agarose affinity chromatography...
March 22, 2018: Archives of Physiology and Biochemistry
Maha Mohamed Sabry, Manal Moustafa Mahmoud, Heba Samy Shoukry, Laila Rashed, Samaa Samir Kamar, Mona Mohamed Ahmed
Apelin and its receptor (APJ) are involved in the regulation of a variety of pathophysiological processes. We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS). Forty eight male albino rats were divided into two groups: control group and diabetic group. Diabetic group was subdivided into: control diabetic, apelin-treated, apelin + losartan-treated, apelin + l-NAME-treated and losartan-treated diabetic subgroup...
March 22, 2018: Archives of Physiology and Biochemistry
Afaf Elsaid, Rasha Zahran, Rami Elshazli, Ahmed El-Sayed, Marwa Abou Samra, Fatma El-Tarapely, Camelia Abdel-Malak
BACKGROUND: Previous reports demonstrated the role of TP53 gene polymorphisms with CRC risk among several ethnic populations. The purpose of this study is to assess the association of the TP53 Arg72Pro and Pro47Ser variants with CRC risk among Egyptian patients. SUBJECTS AND METHODS: This work was conducted on 120 unrelated CRC Egyptian patients who were compared to 140 healthy controls. DNA was genotyped for these variants using the PCR-RFLP technique. RESULTS: CRC patients observed a significant association of the rare genotype of TP53 Arg72Pro polymorphism compared with healthy controls...
March 21, 2018: Archives of Physiology and Biochemistry
Kalaivani A, V V Sathibabu Uddandrao, Brahmanaidu Parim, Saravanan Ganapathy, Nivedha P R, Sushma Chandulee Kancharla, Rameshreddy P, Swapna K, Vadivukkarasi Sasikumar
In this study, we evaluated the ameliorative potential of Cucurbita maxima seeds oil (CSO (100 mg/kg body weight)) supplementation to high fat diet (HFD)-induced obese rats for 30 days on the changes in body weight, markers of lipid metabolism such as LDL, HDL, triglycerides, total cholesterol, adiponectin, leptin, amylase, and lipase. We also investigated the effects of CSO on the changes of lipid metabolic enzymes such as fatty-acid synthase, acetyl CoA carboxylase, carnitine palmitoyl transferase-1, HMG CoA reductase, and inflammatory markers (TNF-α and IL-6)...
March 19, 2018: Archives of Physiology and Biochemistry
Noura Brahmi, Mongi Saoudi, Yamina Kadri, Chomous Kallel, Aida El Euch, Fatma Makni Ayadi, Abdel Halim Harrath, Abdelfatah El Feki, Mohamed Salah Allagui
High fat diet (HFD) exposure is associated with various pathological dysfunctions, including haematological disorders and oxidative stress. The in vitro analysis of AECG revealed the presence of important levels of polyphenols and flavonoids, and denoted antioxidant capacities confirmed by nitric oxide radical (NO• ), reducing the power and HPLC chemical components' determinations. The animals exposed to HFD revealed a severe damage in the blood cells structure and haematological parameters accompanied with a significant decrease in serum Mg2+ and Ca2+ ATPase activities...
March 15, 2018: Archives of Physiology and Biochemistry
Muneeb U Rehman, Shahzada Mudasir Rashid, Saiema Rasool, Sheeba Shakeel, Bilal Ahmad, Sheikh Bilal Ahmad, Hassan Madkhali, Majid Ahmad Ganaie, Sabiya Majid, Showkat Ahmad Bhat
Development of diabetic nephropathy (DN) is directly linked to oxidative stress and inflammation. In this context, inflammatory and oxidative markers have gained much attention as targets for therapeutic intervention. We studied the effect of zingerone in a streptozotocin/high fat diet (STZ/HFD)-induced type 2 diabetic Wistar rat model. Zingerone also known as vanillyl acetone is a pharmacologically active compound present usually in dry ginger. STZ/HFD caused excessive increase in ROS and inflammation in experimental animals...
March 14, 2018: Archives of Physiology and Biochemistry
Sahar M El Agaty
OBJECTIVES: To assess the effect of vitamin D2 and to elucidate the underlying mechanisms on acute myocardial injury induced by isoproterenol (ISO) in diabetic rats. METHODS: Rats were divided into control rats, diabetic rats (DM), diabetic rats received ISO (DM-ISO), and diabetic rats pretreated with vitamin D2 and received ISO (DM-D2 -ISO). RESULTS: Vitamin D2 pretreatment significantly decreased fasting glucose and myocardial malondialdehyde, associated with increased insulin, myocardial glutathione and superoxide dismutase in DM-D2 -ISO versus DM-ISO...
March 8, 2018: Archives of Physiology and Biochemistry
Laleh Pezhman, Farzam Sheikhzadeh Hesari, Rafighe Ghiasi, Mohammad Reza Alipour
OBJECTIVE: The importance of swimming in bone metabolism during type 2 diabetes (T2DM) is not well known. Receptor activator of nuclear factor-kB ligand (RANKL)/ osteoprotegerin (OPG) system as a critical pathway in bone remodeling may play a role in pathogenesis of T2DM. Hence, we tested this pathway and the possible beneficial effects of swim training on T2DM. MATERIALS AND METHODS: Forty male rats were assigned to groups (n = 10): control(C), diabetic (D), exercised control (E), and diabetic exercised (DE)...
March 2, 2018: Archives of Physiology and Biochemistry
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