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Archives of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/28627263/association-of-interleukin-1a-insertion-deletion-gene-polymorphism-and-possible-high-risk-factors-with-non-alcoholic-fatty-liver-disease-in-egyptian-patients
#1
Asmaa R Abdel-Hamed, Maivel H Ghattas, Noha M Mesbah, Samy M Saleh, Dina M Abo-Elmatty
CONTEXT: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression. OBJECTIVE: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. METHODS: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured...
June 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28598692/modulatory-effect-of-garcinol-in-streptozotocin-induced-diabetic-wistar-rats
#2
Kodikonda Madhuri, Prakash Ramachandra Naik
The objective of the study was to evaluate the efficacy of garcinol as an antidiabetic candidate in streptozotocin-induced diabetic Wistar rats. Diabetic rats showed a significant increase in the biochemical parameters such as fasting blood glucose, glycated haemoglobin, urea, alanine aminotransferase and aspartate aminotransferase, malondialdehyde, total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index and a significant decrease in plasma insulin, HOMA-β-cell functioning index, glycogen, high-density lipoprotein cholesterol, body weight and antioxidant enzyme activities, viz...
June 9, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28562072/synthesis-and-carbonic-anhydrase-inhibitory-properties-of-newspiroindoline-substituted-sulphonamide-compounds
#3
Özcan Güleç, Mustafa Arslan, Nahit Gencer, Adem Ergun, Cigdem Bilen, Oktay Arslan
New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of the 14 synthesised sulphonamides (6a-n) on esterase activities of these isoenzymes were studied in vitro. In relation to these activities, the inhibition equilibrium constants (Ki) were determined...
May 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28557619/correction-to-gillies-n-a-et%C3%A2-al-fasting-levels-of-insulin-and-amylin-after-acute-pancreatitis-are-associated-with-pro-inflammatory-cytokines
#4
(no author information available yet)
No abstract text is available yet for this article.
May 30, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28557561/in-vivo-anti-inflammatory-activity-of-aqueous-extract-of-teucrium-polium-against-carrageenan-induced-inflammation-in-experimental-models
#5
Fatma Rahmouni, Latifa Hamdaoui, Tarek Rebai
The aim of this study was to evaluate the anti-inflammatory activity of Teucrium polium (TP). Rats were divided into four groups: group 1 controls received standard diet; group 2 inflamed by carrageenan (Carr) (1% Carr); group 3 as reference inflamed with Carr and treated with Indometacine (Ind) (150 mg/kg bw) and group 4 inflamed with Carr and pre0treated with TP (5 g/L). Oedema volume was measured 1 h to 5 h after injection. Administration of TP or Ind decreased the levels of hematology parameters relative to Carr and reduced the volume of rats induced by Carr...
May 30, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28508677/ketonuria-may-be-associated-with-low-serum-amylase-independent-of-body-weight-and-glucose-metabolism
#6
Kei Nakajima, Eiji Oda
CONTEXT: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA). OBJECTIVE: To investigate the association between ketonuria and LSA. METHODS: We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25-79 years who underwent a health-screening checkup...
May 16, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28502193/early-onset-obesity-and-food-restriction-alter-hepatocyte-metabolism-in-adult-wistar-rats
#7
Nayra Thais D Branquinho, Gabriel Henrique P Cruz, Cristian L Borrasca, Lucas de Paula S Alves, Célia Regina de Godoy Gomes, Vilma Aparecida Ferreira de Godoi, Maria Montserrat Diaz Pedrosa
CONTEXT: Caloric restriction (CR) is suggested for overweight control. OBJECTIVE: Systemic and liver glucose metabolism in the reduced-litter (RL) rat model under 30% CR was investigated. MATERIALS AND METHODS: Newborn litters were organised in control (G9); RL with free diet (G3L); and RL with CR (G3R). Assessments were made at the age of 90 d. RESULTS: Higher liver glycogen content and changes in systemic glucose handling were found in the RL groups...
May 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28480754/low-dose-spironolactone-ameliorates-insulin-resistance-and-suppresses-elevated-plasminogen-activator-inhibitor-1-during-gestational-testosterone-exposure
#8
Lawrence A Olatunji, Taofeek O Usman, Aminat I Akinade, Oluwaseun A Adeyanju, InKyeom Kim, Ayodele O Soladoye
CONTEXT: Elevated gestational circulating testosterone has been associated with pathological pregnancies that increase the risk of development of cardiometabolic disorder in later life. OBJECTIVE: We hypothesised that gestational testosterone exposure, in late pregnancy, causes glucose deregulation and atherogenic dyslipidaemia that would be accompanied by high plasminogen activator inhibitor-1 (PAI-1). The study also hypothesise that low-dose spironolactone treatment would ameliorate these effects...
May 8, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28457144/molecular-effects-of-hesperetin-a-citrus-flavanone-on7-12-dimethylbenz-a-anthracene-induced-buccal-pouch-squamous-cell-carcinoma-in-golden-syrian-hamsters
#9
Sukumar Babukumar, Veerasamy Vinothkumar, Periyannan Velu, Duraisamy Ramachandhiran, Madhavan Ramados Nirmal
In recent years, researchers have been focused on citrus flavanone, a naturally occurring bioactive substance of hesperetin. To investigate the molecular mechanism based chemopreventive efficacy of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch (HBP) squamous cell carcinoma (SCC). The oral tumour was provoked by painted with 0.5% DMBA on left buccal pouch thrice a week for 10 consecutive weeks developed well-differentiated SCC and tumour formation was 100% in DMBA alone. We evaluated the chemopreventive potential of hesperetin by assessing the lipid peroxidation (LPO) by-products, status of enzymatic, non-enzymatic antioxidants, detoxifying agents etc...
May 1, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28452232/genetic-polymorphisms-of-il-23r-rs7517847-and-lep-rs7799039-among-egyptian-patients-with-hepatocellular-carcinoma
#10
Tahani Amer, Rizk El-Baz, Abdel-Rahman Mokhtar, Saad El-Shaer, Rami Elshazli, Ahmad Settin
BACKGROUND: Genetic polymorphisms of IL-23 R (rs7517847) and LEP (rs7799039) have been stated to be associated with various types of human cancers. The purpose of this work is to test the association of these genetic polymorphisms with hepatocellular carcinoma (HCC) among Egyptian patients. SUBJECTS AND METHODS: This study involved 150 unrelated Egyptian HCC patients in addition to 100 healthy controls from the same locality. DNA was genotyped for these genetic polymorphisms using the PCR-RFLP technique...
April 28, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28440667/camelus-dromedarius-glucose-transporter-4-in-silico-analysis-cloning-expression-purification-and-characterisation-in-e-coli
#11
Anwar Ahmed, Mohammed Arshad, Ajamaluddin Malik, Shama Parveen, Abdulrahman M Alsenaidy
Camels have exceptional carbohydrate metabolism as their plasma glucose level is high and have low whole body insulin sensitivity, similar to that observed in type 2 diabetes patients. We aimed at studing an important component of insulin signalling pathway, the GLUT4, in camel. Camelus dromedarius GLUT4 (CdGLUT4) CDS is 1530 nucleotide in length that encodes for a 55KDa protein. CdGLUT4 has 23 amino acid substitutions and 3N-glycosylation sites, compared to 2 in Human GLUT4. 3 D structures of CdGLUT4 and HsGLUT4 generated by homology modelling revealed conservation of characteristic signature motifs...
April 25, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28426339/fasting-levels-of-insulin-and-amylin-after-acute-pancreatitis-are-associated-with-pro-inflammatory-cytokines
#12
Nicola A Gillies, Sayali A Pendharkar, Ruma G Singh, John A Windsor, Madhav Bhatia, Maxim S Petrov
BACKGROUND: The prevalence of metabolic diseases continues to rise worldwide, with a growing recognition of metabolic dysregulation after acute inflammatory diseases such as acute pancreatitis (AP). Adipokines and cytokines play an important role in metabolism and the course of AP, but there is a paucity of research investigating their relationship with pancreatic hormones after AP. This study aimed to explore associations between pancreatic hormones and adipokines as well as cytokines to provide insights into the pathophysiology of altered pancreatic hormone secretion following AP...
April 20, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28372462/polysaccharides-extraction-from-opuntia-stricta-and-their-protective-effect-against-hepg2-cell-death-and-hypolipidaemic-effects-on-hyperlipidaemia-rats-induced-by-high-fat-diet
#13
Bahira Harrabi, Khaled Athmouni, Latifa Hamdaoui, Lobna Ben Mahmoud, Ahmed Hakim, Abdelfattah El Feki, Khaled Zeghal, Hanéne Ghozzi
The aim of this study was to analyse cytoprotective effect of polysaccharides compound from Opuntia stricta (O. stricta) cladode (POS) in vitro including its radical scavenging activities and protective effects against hypercholesterolaemia. Our results showed that glucose was the dominant monosaccharides (30.35%). Arabinose, pyranose, fructose, galactose, glucose, sorbitol, S-inositol, M-inositol, trehalose and saccharose found in this species. O. stricta polysaccharides did not cause any cytotoxic effect on HepG2 cells within the range of concentrations tested (0-400 μgml(-1))...
April 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28368219/reduced-expression-of-adipose-triglyceride-lipase-decreases-arachidonic-acid-release-and-prostacyclin-secretion-in-human-aortic-endothelial-cells
#14
Monika Riederer, Margarete Lechleitner, Harald Köfeler, Saša Frank
BACKGROUND: Vascular endothelial cells represent an important source of arachidonic acid (AA)-derived mediators involved in the generation of anti- or proatherogenic environments. Evidence emerged (in mast cells), that in addition to phospholipases, neutral lipid hydrolases as adipose triglyceride lipase (ATGL) also participate in this process. OBJECTIVE: To examine the impact of ATGL on AA-release from cellular phospholipids (PL) and on prostacyclin secretion in human aortic endothelial cells (HAEC)...
April 3, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276712/chemically-induced-hypoxia-promotes-differential-outcomes-over-preadipocyte-or-adipocyte-macrophage-communication
#15
K Avila-George, K Ramos-Olivares, K Vasquez-Munoz, V Villanueva-Morales, M Reyes-Farias, P Quintero, L Garcia, D F Garcia-Diaz
Expansion of white adipose tissue induce insufficient vascularization, driving hypoxia and low-grade inflammation. Resident preadipocytes are thought to be involved. We evaluated the effects of hypoxia over preadipocytes and adipocytes, to determine which cellular type impacts the most over macrophages activation. 3T3-L1 cells were either differentiated, or maintained undifferentiated. Each group was subjected to the presence or absence of chemical hypoxia (200 μM CoCl2) for 24 h. Conditioned media were used as treatment for murine RAW264...
July 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276711/an-alternative-purification-method-for-human-serum-paraoxonase-1-and-its-interaction-with-methidathion
#16
Nahit Gençer, Emre Yavuz
In this study, an alternative purification method for human Paraoxonase 1 (hPON1) enzyme was developed using two-step procedures, namely ammonium sulphate precipitation and Sepharose-4B-L-tyrosine-1-aminoanthracene hydrophobic interaction chromatography. SDS-polyacrylamide gel electrophoresis of the enzyme indicates a single band with an apparent MW of 43 kDa. The enzyme was purified 674-fold with a yield of 16%. Furthermore, we examined the in vitro effect of methidathion on the enzyme activity to understand the better inhibitory properties of the compound...
July 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276710/effects-of-vanillin-on-potassium-bromate-induced-neurotoxicity-in-adult-mice-impact-on-behavior-oxidative-stress-genes-expression-inflammation-and-fatty-acid-composition
#17
Hajer Ben Saad, Nadia Kharrat, Dorra Driss, Manel Gargouri, Rim Marrakchi, Kamel Jammoussi, Christian Magné, Tahia Boudawara, Samia Ellouz Chaabouni, Khaled Mounir Zeghal, Ahmed Hakim, Ibtissem Ben Amara
CONTEXT: Vanillin is known to possess important antioxidant activity. OBJECTIVE: The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice. MATERIAL AND METHODS: Mice were exposed during 15 days either to potassium bromate (KBrO3), KBrO3+ vanillin or to only vanillin. RESULTS: Our results revealed a significant modification in the fatty acid composition of the KBrO3-treated mice...
July 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276709/high-fat-diet-effects-on-metabolic-responses-to-chronic-stress
#18
Marzieh Nemati, Homeira Zardooz, Fatemeh Rostamkhani, Alireza Abadi, Forough Foroughi
CONTEXT: High-fat diets and chronic stress are prevalent risk factors for various chronic diseases in modern societies. OBJECTIVE: This study investigated the effect of high-fat diet on glucose-related metabolic responses to chronic foot-shock stress. MATERIALS AND METHODS: Male rats were divided into high-fat diet (containing 54.21% saturated and 44.89% unsaturated fatty acids) and normal diet groups and then into stress and non-stress subgroups...
July 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28276708/the-effect-of-carnosine-on-methylglyoxal-induced-oxidative-stress-in-rats
#19
Zülbiye Yılmaz, Esra Betül Kalaz, A Fatih Aydın, Merva Soluk-Tekkeşin, Semra Doğru-Abbasoğlu, Müjdat Uysal, Necla Koçak-Toker
Methylglyoxal (MG) is generated from glycolytic metabolites, lipid peroxidation, glucose autooxidation and protein glycation. It is a prooxidant inducing oxidative stress and formation of advanced glycation end products (AGE). Effect of carnosine (CAR) as an antioxidant on toxicity due to MG has generated interest. In this study, rats were given incrementally increased doses (100-300 mg/kg) of MG in drinking water for ten weeks. CAR (250 mg/kg i.p.) was administered with MG. Plasma thiobarbituric reactive substances (TBARS), protein carbonyl (PC), advanced oxidation protein products (AOPP) and AGE levels were elevated by MG, and CAR decreased PC, AOPP and AGE levels...
July 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28084108/enhanced-hepatic-insulin-signaling-in-the-livers-of-high-altitude-native-rats-under-basal-conditions-and-in-the-livers-of-low-altitude-native-rats-under-insulin-stimulation-a-mechanistic-study
#20
Hussain Al Dera, Samy M Eleawa, Fahaid H Al-Hashem, Moeber M Mahzari, Ibrahim Hoja, Mahmoud Al Khateeb
This study was designed to investigate the role of the liver in lowering fasting blood glucose levels (FBG) in rats native to high (HA) and low altitude (LA) areas. As compared with LA natives, besides the improved insulin and glucose tolerance, HA native rats had lower FBG, at least mediated by inhibition of hepatic gluconeogenesis and activation of glycogen synthesis. An effect that is mediated by the enhancement of hepatic insulin signaling mediated by the decreased phosphorylation of TSC induced inhibition of mTOR function...
July 2017: Archives of Physiology and Biochemistry
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