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Archives of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/30513216/diabetes-induced-testicular-oxidative-stress-inflammation-and-caspase-dependent-apoptosis-the-protective-role-of-metformin
#1
Victor Udo Nna, Ainul Bahiyah Abu Bakar, Azlina Ahmad, Mahaneem Mohamed
CONTEXT: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported. OBJECTIVE: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state. METHODS: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b...
December 4, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30501137/the-preventive-effect-of-aqueous-extract-of-rosemary-rosmarinus-officinalis-leaves-against-the-nephrotoxicity-of-carbon-tetrachloride-in-mice
#2
Houda Hamed, Salha Boulila, Ferdaws Ghrab, Rim Kallel, Tahia Boudawara, Abdelfattah El Feki
The present study aimed to evaluate the performance effect of aqueous extract of Rosmarinus officinalis (AERO) against the kidney toxicity induced by CCl4 in mice. The results showed that the renal damage induced by CCl4 was associated with a rise in oxidative stress monitored by a significant increase of TBARS and PCO levels (+89% and +136% respectively, p < .001) and a significant decrease of GSH level (-68%, p < .001) and antioxidants enzymes such as SOD, CAT, and GPX activities (-41.7%, -47...
November 30, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30468085/cold-stress-modulates-redox-signalling-in-murine-fresh-bone-marrow-cells-and-promotes-osteoclast-transformation
#3
Siddhartha Singh, Ajeya Nandi, Oly Banerjee, Ankita Bhattacharjee, Shilpi Kumari Prasad, Bithin Kumar Maji, Adipa Saha, Sandip Mukherjee
CONTEXT: Alteration of redox signalling and RANK-L expression in FBMCs of mice exposed to different intensities of cold stress (15 °C, 8 °C and 4 °C) were studied. OBJECTIVE: To understand the effects of varying intensities of cold stress on murine FBMCs and its impact on osteoclastogenesis. MATERIALS AND METHODS: FBMCs were isolated from mice exposed to different intensities of cold stress and used for immunoblotting and biochemical assays...
November 23, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30465447/tempol-modulates-the-leukocyte-response-to-inflammatory-stimuli-and-attenuates-endotoxin-induced-sickness-behaviour-in-mice
#4
Samuel Nuno Pereira Lima, Cláudio Daniel Cerdeira, Gérsika Bitencourt Santos, Mateus de Mello Fernandes, Alexandre Giusti-Paiva, Maísa Ribeiro Pereira Lima Brigagão
BACKGROUND AND AIMS: Lipopolysaccharide (LPS), an endotoxin, is a component of the outer membrane of Gram-negative bacteria that is able to activate the peripheral immune system, leading to changes in signalling pathways that act locally and systemically to achieve adaptive responses. Sickness behaviour is a motivational state in response to endotoxin exposure and includes depressed activity and a reduction of exploratory behaviour, potentially reorganising organism priorities to cope with infectious diseases...
November 22, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30465443/exercise-augments-the-modulatory-effects-of-vitamin-e-on-pre-diabetes-induced-aortopathy-a-potential-role-of-adiponectin
#5
Mohammad A Dallak, Bahjat Al-Ani, Abbas O El Karib, Mohamed Abd Ellatif, Refaat A Eid, Rihab Al-Ani, Hesham M Mahmoud, Mohamed A Haidara
BACKGROUND: We tested the hypothesis that vitamin E may protect against pre-diabetes-induced aortic injury (aortopathy), and exercise can augment the action of vitamin E. MATERIAL AND METHODS: Rats were either fed with a high fat and fructose diet (HFD) (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. The three protective groups were treated with vitamin E (HFD + Vit E), swimming exercises (HFD + Ex), and vitamin E plus swimming exercises (HFD + VitE + Ex), respectively...
November 22, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30463448/serum-levels-of-subfatin-in-patients-with-type-2-diabetes-mellitus-and-its-association-with-vascular-adhesion-molecules
#6
Reza Fadaei, Maryam Dadmanesh, Nariman Moradi, Reza Ahmadi, Abolfazl Shokoohi Nahrkhalaji, Hassan Aghajani, Khodayar Ghorban
Subfatin is a newly discovered adipokine with insulin-sensitizing properties. Studies reported conflicting data with regard to the circulating levels and expression of Subfatin in the context of type 2 diabetes mellitus (T2DM) and obesity. The present study was conducted on 52 patients with T2DM, 36 prediabetes subjects, and 50 controls. The serum levels of Subfatin, adhesion molecules were measured by the ELISA technique. The serum Subfatin was lower in the T2DM and prediabetes groups. The serum levels of adhesion molecules were higher in the T2DM group...
November 21, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30451544/associations-between-ketone-bodies-and-fasting-plasma-glucose-in-individuals-with-post-pancreatitis-prediabetes
#7
Sakina H Bharmal, Sayali A Pendharkar, Ruma G Singh, David Cameron-Smith, Maxim S Petrov
CONTEXT: Levels of ketone bodies are altered in both acute pancreatitis and type 1 and type 2 diabetes. However, the role of ketone bodies in the pathogenesis of abnormal glucose metabolism after pancreatitis is largely unknown. OBJECTIVE: To investigate the associations between ketone bodies and glucose homeostasis in individuals with post-pancreatitis prediabetes (PPP) versus normoglycaemia after pancreatitis (NAP). METHODS: Fasting blood samples were analysed for acetoacetate, β-hydroxybutyrate, and markers of glucose metabolism at a median of 26 months after acute pancreatitis...
November 19, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30451000/physiological-role-of-adiponectin-in-different-tissues-a-review
#8
S Esmaili, M Hemmati, M Karamian
Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. This role is accomplished by regulating anabolic pathways and reducing oxidative stress in the renal tissue. This hormone in the liver prevents the accumulation of fat and free radicals that cause damage to liver cells and tissue...
November 18, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30450993/insulin-resistance-and-oxidative-marker-in-women-with-pcos
#9
Doddappa M Bannigida, B Shivananda Nayak, R Vijayaraghavan
Polycystic Ovary Syndrome is a multifactorial reproductive problem and a leading cause of female infertility worldwide. Evidences have shown that Oxidative Stress and decreased antioxidant status are often linked with PCOS. Insulin Resistance in PCOS patients ranges from 50% to 70% and may encourage OS by production of reactive oxygen species. OBJECTIVE: Our study determines serum MDA levels along with plasma glucose, serum insulin, and insulin resistance in obese and nonobese PCOS subjects...
November 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30450988/pretreatment-of-simvastatin-on-liver-trace-element-levels-during-endotoxemia
#10
Hatice Yorulmaz, Elif Ozkok, Goksel Demir, Ibrahim Ertugrul Yalcin, Gulten Ates, Vakur Olgac, Sule Tamer
There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels was evaluated in liver during endotoxemia. Rats were divided into control, LPS, simvastatin, and simvastatin + LPS. The histopathologic examination of the liver was performed using hematoxylin and eosin. Selenium, zinc, iron, manganese, magnesium, and copper were analyzed using inductively coupled plasma - optical emission spectroscopy...
November 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30449203/effect-of-amylin-on-memory-and-central-insulin-resistance-in-a-rat-model-of-alzheimer-s-disease
#11
Seham Zakaria Nassar, Noha Mohamed Badae, Yasmine Amr Issa
CONTEXT: Alzheimer's disease is strongly associated with brain insulin signalling. OBJECTIVE: Investigating the effect of amylin as a novel treatment in streptozotocin (STZ) rat model of AD. MATERIALS AND METHODS: Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg). Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks. RESULTS: Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus...
November 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30449185/neuregulin-1-treatment-improves-glucose-tolerance-in-diabetic-db-db-mice-but-not-in-healthy-mice
#12
Gaël Ennequin, Kevin Caillaud, Vivien Chavanelle, Allison Teixeira, Monique Etienne, Xinyan Li, Nathalie Boisseau, Pascal Sirvent
CONTEXT: Neuregulin 1 (NRG1) and ErbB receptors are involved in glucose homeostasis. However, the effects of the neuregulin 1-ErbB pathway activation on glucose metabolism in liver are controversial. OBJECTIVE: Assess NRG1 and ErbB signalling in liver and the effects of 8-week treatment with NRG1 on glucose homeostasis in diabetic db/db mice and in control healthy mice. RESULTS: NRG1 improved glucose, insulin and insulin sensitivity index during OGTT in db/db mice, but not in control mice...
November 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30445857/membrane-insertion-and-intercellular-transfer-of-glycosylphosphatidylinositol-anchored-proteins-potential-therapeutic-applications
#13
Günter A Müller
Anchorage of a subset of cell surface proteins in eukaryotic cells is mediated by a glycosylphosphatidylinositol (GPI) moiety covalently attached to the carboxy-terminus of the protein moiety. Experimental evidence for the potential of GPI-anchored proteins (GPI-AP) of being released from cells into the extracellular environment has been accumulating, which involves either the loss or retention of the GPI anchor. Release of GPI-AP from donor cells may occur spontaneously or in response to endogenous or environmental signals...
November 16, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30406686/naringenin-prevents-doxorubicin-induced-toxicity-in-kidney-tissues-by-regulating-the-oxidative-and-inflammatory-insult-in-wistar-rats
#14
Tajdar Husain Khan, Majid Ahmad Ganaie, Khalid Mofleh Alharthy, Hassan Madkhali, Basit Latief Jan, Ishfaq Ahmad Sheikh
This study is undertaken to investigate the effects of naringenin on doxorubicin- (Dox) induced nephrotoxicity in Wistar rats. Dox 10 mg/kg body weight was administered intraperitoneally once and naringenin 50 and 100 mg/kg body weight was administered orally daily for 21 d. Dox-induced oxidative stress lead to steep elevation in blood urea nitrogen (BUN), creatinine, lactate dehydrogenase (LDH), and kidney injury molecule-1 (KIM-1), compared to control, treatment with naringenin preserved kidney functions...
November 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30375252/smilax-china-leaf-extracts-suppress-pro-inflammatory-adhesion-response-in-human-umbilical-vein-endothelial-cells-and-proliferation-of-hela-cells
#15
Clement O Tettey, Injun Yang, Heung-Mook Shin
OBJECTIVE: The objective of this study was to investigate the anti-inflammatory and anticancer effects of the leaves of Smilax china. METHODOLOGY: The aqueous extract was examined for its anti-inflammatory effects on tumour necrosis factor (TNF)-α-induced inflammation in HUVECs whereas the aqueous (water), ethyl acetate (EA), butanol (B) and methylene chloride (MC) extracts were examined for their anticancer effect on HeLa cells. RESULTS: The aqueous extract suppressed the (TNF)-α-induced expression of ICAM-1, VCAM-1 and TNF-R1 and attenuated the expression of MCP-1, MMP-9, NF-kB and IFN-γ...
October 30, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30372625/superoxide-dismutase-a-review-and-a-modified-protocol-for-activities-measurements-in-rat-livers
#16
Lilian Brites Campos-Shimada, Eduardo Hideo Gilglioni, Rosângela Fernandes Garcia, Elismari Rizato Martins-Maciel, Emy Luiza Ishii-Iwamoto, Clairce Luzia Salgueiro-Pagadigorria
Superoxide dismutase (SOD) enzymes are considered the first line of Defence against reactive oxygen species. Among the intracellular isoforms of SOD, Cu,ZnSOD is widely distributed, and the MnSOD is localised in the mitochondria. The SOD activities have been measured indirectly by inhibiting oxidation reactions. Most techniques assessing the hepatic SOD activity are adaptations of classical methods and differ significantly from each other. This work assessed the hepatic Cu,ZnSOD activity in the supernatants of two different centrifugations, using two isotonic medium and the pyrogallol method...
October 29, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30320520/high-intensity-interval-training-hiit-effectively-enhances-heart-function-via-mir-195-dependent-cardiomyopathy-reduction-in-high-fat-high-fructose-diet-induced-diabetic-rats
#17
Soheyla Khakdan, Maryam Delfan, Maryam Heydarpour Meymeh, Faranak Kazerouni, Hamid Ghaedi, Mehrnoosh Shanaki, Fatemeh Kalaki-Jouybari, Sattar Gorgani-Firuzjaee, Ali Rahimipour
AIMS: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard. METHODS: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT)...
October 15, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30320517/hemostatic-effect-of-acylated-ghrelin-in-control-and-sleeve-gastrectomy-induced-rats-mechanisms-of-action
#18
Mohamed Darwesh Morsy
This study investigated the effect of acylated ghrelin (AG) deficiency after sleeve gastrectomy (SG) or chronic administration in control and SG-indiuced rats on platelet function, coagulation, and fibrinolysis. Administration of AG (100 µg/kg, subcutaneously) to control or SG rats significantly inhibited platelets aggregation and lowered levels of Von-Willebrand factor (vWF), fibrinogen, and thromboxane B2. Concomitantly, it decreased circulatory levels and aortic expression levels of plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) and increased the aortic expression of the endothelial nitric oxidase (eNOS)...
October 15, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30320514/anti-inflammatory-potential-of-trifolium-pratense-l-leaf-extract-in-lps-stimulated-raw264-7-cells-and-in-a-rat-model-of-carrageenan-induced-inflammation
#19
Seul Ah Lee, Bo-Ram Park, Sung-Min Moon, Seul Hee Han, Chun Sung Kim
This study evaluated the anti-inflammatory potential of a 40% prethanol extract of Trifolium pratense leaves (40% PeTP) using in vitro (RAW264.7 cells) and in vivo (carrageenan-induced inflammation model) experiments. Pretreatment with 40% PeTP significantly inhibited the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in RAW264...
October 15, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/30318957/high-intensity-interval-training-hiit-alleviated-nafld-feature-via-mir-122-induction-in-liver-of-high-fat-high-fructose-diet-induced-diabetic-rats
#20
Fatemeh Kalaki-Jouybari, Mehrnoosh Shanaki, Maryam Delfan, Sattar Gorgani-Firouzjae, Soheyla Khakdan
BACKGROUND: Exercise intervention is strongly recommended to manage metabolic diseases. In this study, we investigate, whether HIIT and CET can induce hepatic miR-122 expression, NAFLD rats with diabetes. METHODS: 40 Wistar rats divided into 2 groups, non-diabetic (NDC) and diabetic .Type 2 diabetes was induced by high-fat high-fructose diet (HFHFD). Then diabetic rats were subdivided into three groups: diabetic control (HFHFD + DC), CET (HFHFD + CET), and HIIT (HFHFD + HIIT)...
October 13, 2018: Archives of Physiology and Biochemistry
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