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Archives of Physiology and Biochemistry

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https://www.readbyqxmd.com/read/28817314/role-of-geraniol-against-lead-acetate-mediated-hepatic-damage-and-their-interaction-with-liver-carboxylesterase-activity-in-rats
#1
Ahmet Ozkaya, Zafer Sahin, Muslum Kuzu, Yavuz Selim Saglam, Mustafa Ozkaraca, Mirac Uckun, Ertan Yologlu, Veysel Comakli, Ramazan Demirdag, Semra Yologlu
In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol + lead acetate groups. 8-OhDG immunoreactivity, mononuclear cell infiltrations and hepatic lead concentration were lower in the geraniol + lead acetate group than the lead acetate group...
August 17, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28796539/carbonic-anhydrase-i-ii-autoantibodies-and-oxidative-status-in-long-term-follow-up-of-patients-with-crimean-congo-haemorrhagic-fever
#2
Hülya Yilmaz, Uğur Kostakoğlu, Selim Demir, Firdevs Aksoy, Ahmet Menteşe, Süleyman Caner Karahan, İftihar Köksal, Ahmet Alver, Gürdal Yilmaz
CONTEXT: Crimean-Congo haemorrhagic fever (CCHF) is a life-threatening acute febrile haemorrhagic disease. OBJECTIVE: This study was to measure levels of the oxidative stress biomarkers malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) and of CA I-II autoantibodies as biomarkers for autoimmunity and course of disease in patients with CCHF. METHODS: Seventy CCHF patients and 39 healthy control volunteers were included in the study...
August 10, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28792233/synthesis-of-chalcone-imide-derivatives-and-investigation-of-their-anticancer-and-antimicrobial-activities-carbonic-anhydrase-and-acetylcholinesterase-enzymes-inhibition-profiles
#3
Umit Muhammet Kocyigit, Yakup Budak, Meliha Burcu Gürdere, Fatih Ertürk, Belkız Yencilek, Parham Taslimi, İlhami Gülçin, Mustafa Ceylan
The new 1-(4-(3-(aryl)acryloyl)phenyl)-1H-pyrrole-2,5-diones (5a-g) were prepared from 4'-aminchalcones (3a-g) and screened for biological activities. All compounds (3a-g and 5a-g), except 3d and 3e displayed good cytotoxic activities with IC50 values in the range of 7.06-67.46 μM. IC50 value of 5-fluorouracil (5-FU) was 90.36 μM. Moreover, most of compounds 5a-g showed high antibacterial activity with 8-20 mm of inhibition zone (19-25 mm of Sulbactam-Cefoperazone (SCF)). In addition, they showed good inhibitory action against acetylcholinesterase (AChE), and human carbonic anhydrase I, and II (hCA I and hCA II) isoforms...
August 9, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28780883/early-detection-of-macular-and-peripapillary-changes-with-spectralis-optical-coherence-tomography-in-patients-with-prediabetes
#4
Muhammed Şahin, Alparslan Şahin, Faruk Kılınç, Ümit Karaalp, Harun Yüksel, Zeynep Gürsel Özkurt, Fatih Mehmet Türkcü, İhsan Çaça
PURPOSE: To compare the retina ganglion cell complex (GCC) layer and peripapillary nerve fibre layer thickness (pRNFL) in patients with prediabetes and healthy subjects analysed by spectral domain optical coherence tomography (SD-OCT). METHODS: This cross-sectional and comparative study included prediabetic patients and healthy subjects. All participants underwent SD-OCT measurement of pRNFL thickness, and GCC thickness. RESULTS: A total of 30 eyes of the 30 patients with prediabetes and 30 eyes of 30 controls were included...
August 5, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28758816/the-interactions-of-cephalosporins-on-polyol-pathway-enzymes-from-sheep-kidney
#5
Bülent Şengül, Şükrü Beydemir
CONTEXT: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine. OBJECTIVE: An investigation of the effects on sheep renal aldose reductase (AR) and sorbitol dehydrogenase (SDH) of cefoperazone, cefazolin, cefuroxime, ceftazidime and ceftriaxone as cephalosporin drugs was carried out in the present study. METHODS: AR and SDH were purified from sheep kidney by ion exchange, gel filtration and affinity methods with approximately 219- and 484-fold, respectively...
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28758807/correction-to-nakajima-and-oda-ketonuria-may-be-associated-with-low-serum-amylase-independent-of-body-weight-and-glucose-metabolism
#6
(no author information available yet)
No abstract text is available yet for this article.
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28758804/rapamycin-mitigates-erythrocyte-membrane-transport-functions-and-oxidative-stress-during-aging-in-rats
#7
Abhishek Kumar Singh, Sandeep Singh, Geetika Garg, Syed Ibrahim Rizvi
Erythrocyte membrane is a suitable model to study various metabolic and physiological functions as it undergoes variety of biochemical changes during aging. An age-dependent modulatory effect of rapamycin on erythrocyte membrane functions is completely unknown. Therefore, the present study was undertaken to investigate the effect of rapamycin on age-dependent impaired activities of transporters/exchangers, altered levels of redox biomarkers, viz. protein carbonyl (PC), lipid hydroperoxides (LHs), total thiol (-SH), sialic acid (SA) and intracellular calcium ion [Ca(2+)]i, and osmotic fragility of erythrocyte membrane...
July 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28719240/cytoprotective-effects-of-essential-oil-of-pinus-halepensis-l-against-aspirin-induced-toxicity-in-iec-6-cells
#8
Hafsia Bouzenna, Najla Hfaiedh, Mouhamed Bouaziz, Marie-Agnès Giroux-Metges, Abdelfattah Elfeki, Hélène Talarmin
CONTEXT: Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE: This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS: The cytoprotection of the oil against toxicity of aspirin on the small intestine epithelial cells IEC-6 was tested. RESULTS: The obtained results have shown that 35 different compounds were identified...
July 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28714319/protective-effect-of-teucrium-polium-on-carbon-tetrachloride-induced-genotoxicity-and-oxidative-stress-in-rats
#9
Fatma Rahmouni, Mongi Saoudi, Nahed Amri, Abdelfattah El-Feki, Tarek Rebai, Riadh Badraoui
This study aimed to investigate the protective effects of Teucrium polium (TP) on carbon tetrachloride (CCl4) induced spleen, erythrocyte's oxidative stress, and genotoxicity in rats. TP was found to contain large amounts of polyphenols (150 mg GAE/G of dry plant) and flavonoids (60 mg QE/g of quercetin dry plant). The CCl4 (0.5 ml/kg) treated rats exhibited significant reductions in serum vitamin A (VA), vitamin E (VE) and total antioxidant status (TAS). Thiobarbituric acid reactive substances (TBARS) and conjugated dienes (CD) were significantly high in the CCl4 group compared to controls...
July 16, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28708416/subchronic-exposure-to-kalach-360-sl-induced-endocrine-disruption-and-ovary-damage-in-female-rats
#10
Latifa Hamdaoui, Manel Naifar, Fatma Rahmouni, Bahira Harrabi, Fatma Ayadi, Zouheir Sahnoun, Tarek Rebai
Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. Female Wistar rats were divided into three groups: group 1 was used as a control; group 2 orally received 0.07 ml of KL, (126 mg of G/kg) and group 3 orally received 0...
July 14, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28704075/arecoline-cannot-alter-testicular-dysfunction-and-pineal-activation-caused-by-noise-in-wistar-rat
#11
Indraneel Saha, Aniruddha Chatterjee, Urmi Chatterji, B R Maiti
Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Noise exposure (100 dB, 6 h daily, 10 days) caused pineal stimulation ultrastructurally and at indoleamines level. Leydig cell dysfunction with fall of testosterone level and suppression of sex accessories were noticed...
July 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28699791/a-synergistic-protective-effect-of-selenium-and-taurine-against-experimentally-induced-myocardial-infarction-in-rats
#12
Mohammad Dallak
This study investigated the protective effect of subacute pre-adminsitration of either selenium (Se), taurine (Tau), or both drugs in combination against experimentally induced myocardial infarction (MI) in rats and illustrates the possible mechanisms of action. While solely pre-administration of Se or Tau resulted in partial amelioration in all of the measured parameters in MI rats, concomitant administration of both drugs to MI rats significantly restored contractility function by increasing LVSP and decreasing LVEDP and significantly normalized serum levels of LDH, CK-MB and BNP and restored normal cardiac architecture...
July 12, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28696785/exendin-4-a-glucagon-like-peptide-1-receptor-agonist-downregulates-hepatic-receptor-for-advanced-glycation-end-products-in-non-alcoholic-steatohepatitis-rat-model
#13
Mona M Allam, Walaa B El Gazzar
CONTEXT: Exendin-4, a glucagon-like peptide-1 receptor agonist has been shown to have curative effects on hepatic steatosis in murine models. OBJECTIVE: The present study aimed to elucidate the effect of Exendin-4 on hepatic receptor for advanced glycation end products (RAGE) mRNA expression in non-alcoholic steatohepatitis (NASH) rat model induced by high-fat diet. METHODS: NASH was induced by high-fat diet intake, and Exendin-4 was given in two different doses...
July 11, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28692354/potential-protective-effects-of-polysaccharide-extracted-from-ulva-lactuca-against-male-reprotoxicity-induced-by-thiacloprid
#14
Intissar Kammoun, Intidhar Bkhairia, Fatma Ben Abdallah, Imen Jaballi, Naourez Ktari, Ons Boudawara, Moncef Nasri, Neji Gharsallah, Ahmed Hakim, Ibtissem Ben Amara
CONTEXT: Polysaccharides (PSs) from seaweeds have been reported to possess biological activity of potential medicinal values. OBJECTIVE: The current study was conducted to establish the protective effects of PS extracted from Ulva lactuca against oxidative stress induced by Thiacloprid (THC) in the rat reproductive system. MATERIALS AND METHODS: Rats were exposed either to THC, THC + PS (100 mg/kg), or THC + PS (200 mg/kg). RESULTS: Our study showed that THC induced severe disorders in the functional sperm parameters...
July 10, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28692348/the-g-allele-of-mmp12-82-a%C3%A2-%C3%A2-g-promoter-polymorphism-as-a-protective-factor-for-copd-in-bulgarian-population
#15
Tanya Tacheva, Dimo Dimov, Elina Aleksandrova, Monika Bialecka, Maya Gulubova, Tatyana Vlaykova
Chronic inflammation and remodelling of the small airways are features related to chronic obstructive pulmonary disease (COPD). In the current study, we aimed to explore the possible role of MMP12 -82 A > G (rs2276109) promoter polymorphism in the development of COPD in a population from Bulgaria (167 patients with COPD and 119 control individuals). The genotype and allele distributions differed significantly between COPD patients and controls (p = .010 and p = .043, respectively, χ(2) test)...
July 10, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28686483/elevated-resting-heart-rate-is-associated-with-the-severity-of-coronary-artery-disease-in-non-treated-patients-who-underwent-coronary-angiography-potential-role-of-lipoprotein-subfractions
#16
Yan Zhang, Na-Qiong Wu, Rui-Xia Xu, Sha Li, Cheng-Gang Zhu, Yuan-Lin Guo, Ying Gao, Ping Qing, Chuan-Jue Cui, Jing Sun, Jian-Jun Li
OBJECTIVE: To assess the association between resting heart rate (RHR) and lipoprotein subfractions to provide potential evidence for the relationship between RHR and severity of CAD. METHODS: A total of 1119 consecutive non-treated subjects scheduled for coronary angiography were enrolled. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) separation were performed by Lipoprint System. The link of RHR with lipoprotein subfractions was assessed. RESULTS: Increased RHR was significantly associated with higher triglyceride, total cholesterol, non-HDL-cholesterol, and apolipoprotein B (all p < ...
July 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28627263/association-of-interleukin-1a-insertion-deletion-gene-polymorphism-and-possible-high-risk-factors-with-non-alcoholic-fatty-liver-disease-in-egyptian-patients
#17
Asmaa R Abdel-Hamed, Maivel H Ghattas, Noha M Mesbah, Samy M Saleh, Dina M Abo-Elmatty
CONTEXT: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression. OBJECTIVE: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations. METHODS: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured...
June 18, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28598692/modulatory-effect-of-garcinol-in-streptozotocin-induced-diabetic-wistar-rats
#18
Kodikonda Madhuri, Prakash Ramachandra Naik
The objective of the study was to evaluate the efficacy of garcinol as an antidiabetic candidate in streptozotocin-induced diabetic Wistar rats. Diabetic rats showed a significant increase in the biochemical parameters such as fasting blood glucose, glycated haemoglobin, urea, alanine aminotransferase and aspartate aminotransferase, malondialdehyde, total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index and a significant decrease in plasma insulin, HOMA-β-cell functioning index, glycogen, high-density lipoprotein cholesterol, body weight and antioxidant enzyme activities, viz...
June 9, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28562072/synthesis-and-carbonic-anhydrase-inhibitory-properties-of-newspiroindoline-substituted-sulphonamide-compounds
#19
Özcan Güleç, Mustafa Arslan, Nahit Gencer, Adem Ergun, Cigdem Bilen, Oktay Arslan
New spiroindoline-substituted sulphonamide compounds were synthesised and their inhibitory effects on the activity of purified human carbonic anhydrase I and II were evaluated. Human carbonic anhydrase isoenzymes (hCA-I and hCA-II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of the 14 synthesised sulphonamides (6a-n) on esterase activities of these isoenzymes were studied in vitro. In relation to these activities, the inhibition equilibrium constants (Ki) were determined...
May 31, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28557619/correction-to-gillies-n-a-et%C3%A2-al-fasting-levels-of-insulin-and-amylin-after-acute-pancreatitis-are-associated-with-pro-inflammatory-cytokines
#20
(no author information available yet)
No abstract text is available yet for this article.
May 30, 2017: Archives of Physiology and Biochemistry
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