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Archives of Physiology and Biochemistry

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October 6, 2016: Archives of Physiology and Biochemistry
Tomasz Szkudelski, Katarzyna Szkudelska
Adipose tissue plays a key role in energy homeostasis. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an important intracellular energy sensor. Effects of activation of AMPK by aminomidazole-4-carboxamide ribonucleotide (AICAR) on lipolysis in the rat adipocytes were determined in the presence of 3 or 12 mM glucose. Response to epinephrine or dibutyryl-cAMP was higher in the presence of 12 mM glucose. AICAR decreased lipolysis, also when glucose was replaced by alanine or succinate and without decrease in cAMP levels...
September 22, 2016: Archives of Physiology and Biochemistry
Tamara Džinić, Sonja Hartwig, Stefan Lehr, Norbert A Dencher
Cytotoxic effects, including oxidative stress, of low linear energy transfer (LET)-ionizing radiation are often underestimated and studies of their mechanisms using cell culture models are widely conducted with cells cultivated at atmospheric oxygen that does not match its physiological levels in body tissues. Also, cell differentiation status plays a role in the outcome of experiments. We compared effects of 2 Gy X-ray irradiation on the physiology and mitochondrial proteome of nondifferentiated and human neuroblastoma (SH-SY5Y) cells treated with retinoic acid cultivated at 21% and 5% O2...
September 10, 2016: Archives of Physiology and Biochemistry
Alexander Navarrete Santos, Junfeng Yan, Peter Lochmann, Heike Pfeil, Michael Petersen, Andreas Simm, Hendrik Treede, Hans H Sievers, Salah A Mohamed
Dilatation of the ascending aorta is a common occurrence in patients with bicuspid aortic valve (BAV). The aim of the current study was to characterize collagen content in advanced glycation end products (AGEs) of dilated aortic tissue from two distinct areas, concave and convex aortic sites in patients with BAV and TAV. Collagen contents extracted from 100 mg tissue was isolated by enzymatic digestion using pepsin and the nondigested material was further digested using cyanogen bromide, insoluble collagen fraction (ICF) was extracted by hydrochloric acid hydrolysis...
September 5, 2016: Archives of Physiology and Biochemistry
Lucia Berti, Sonja Hartwig, Martin Irmler, Bernhard Rädle, Dorothea Siegel-Axel, Johannes Beckers, Stefan Lehr, Hadi Al-Hasani, Hans-Ulrich Häring, Martin Hrabě de Angelis, Harald Staiger
CONTEXT: Perivascular adipose tissue (PVAT) is suggested to impact on vascular cells via humoral factors, possibly contributing to endothelial dysfunction and atherosclerosis. OBJECTIVE: To address whether the hepatokine fibroblast growth factor (FGF) 21 affects the PVAT secretome. METHODS: Human perivascular (pre)adipocytes were subjected to targeted proteomics and whole-genome gene expression analysis. RESULTS: Preadipocytes, as compared to adipocytes, secreted higher amounts of inflammatory cytokines and chemokines...
August 5, 2016: Archives of Physiology and Biochemistry
Suat Tekin, Yavuz Erden, Suleyman Sandal, Ebru Etem Onalan, Fatma Ozyalin, Hasan Ozen, Bayram Yilmaz
Apelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n = 10). Apelin-13 at three different dosages (1, 5 and 50 μg/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p < 0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p < 0...
August 5, 2016: Archives of Physiology and Biochemistry
Torgrim Mikal Langleite, Jørgen Jensen, Frode Norheim, Hanne Løvdal Gulseth, Daniel Steensen Tangen, Kristoffer Jensen Kolnes, Ansgar Heck, Tryggve Storås, Guro Grøthe, Marius Adler Dahl, Anders Kielland, Torgeir Holen, Hans Jørgen Noreng, Hans Kristian Stadheim, Atle Bjørnerud, Egil Ivar Johansen, Birgitte Nellemann, Kåre Inge Birkeland, Christian A Drevon
CONTEXT: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. OBJECTIVE: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia. MATERIAL AND METHODS: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise...
October 2016: Archives of Physiology and Biochemistry
Nilsel Okudan, Muaz Belviranli
This study investigated the effects of exercise training on oxidative stress, and antioxidant defense markers in the liver tissues of young and aged rats. Two age groups of 4-(young) and 20-months-(aged) old male Wistar rats were performed exercise training program consisted of swimming exercise for 8 weeks. The biomarkers of pro/antioxidant status malondialdehyde (MDA), protein carbonyl (PC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), total glutathione (GSH) and superoxide dismutase (SOD) were assessed by commercially available kits...
October 2016: Archives of Physiology and Biochemistry
Sandeep Singh, Kanti Bhooshan Pandey, Syed Ibrahim Rizvi
Alterations at the level of plasma membrane are reported to play an important role in cellular senescence. The present study was undertaken to correlate cellular senescence, membrane transport processes and organismal aging. To achieve this objective activities of membrane linked Na(+)/K (+) ATPase (NKA), Na(+)/H(+) exchanger (NHE) and correlation with membrane hydrxyperoxide level, sialic acid content and membrane protein oxidation was studied in density-gradient fractionated young and old erythrocytes from 4 and 24 month old Wistar rats...
October 2016: Archives of Physiology and Biochemistry
Daniela Iv Koleva, Maria M Orbetzova, Julia G Nikolova, Stefan B Tyutyundzhiev
INTRODUCTION: Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE: To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in women with polycystic ovary syndrome (PCOS). METHODS: The study included 76 PCOS women divided into insulin resistant and non-insulin resistant...
October 2016: Archives of Physiology and Biochemistry
Imen Ghorbel, Mariem Chaabane, Awatef Elwej, Ons Boudawara, Sameh Abdelhedi, Kamel Jamoussi, Tahya Boudawara, Najiba Zeghal
Hepatotoxicity, induced by aluminium chloride (AlCl3), has been well studied but there are no reports about liver metallothionein (MT) genes induction. Therefore, it is of interest to establish the mechanism involving the relation between MT gene expression levels and the oxidative stress status in hepatic cells of aluminium-treated rats. Aluminium (Al) was administered to rats in their drinking water at a dose of 50 mg/kg body weight for three weeks. AlCl3 provoked hepatotoxicity objectified by an increase in malondialdehyde (MDA), hydrogen peroxide (H2O2), advanced oxidation protein products (AOPP), protein carbonyls (PCO) and a decrease in reduced glutathione (GSH), non-protein thiols (NPSH) and vitamin C...
October 2016: Archives of Physiology and Biochemistry
Ghada A Abdel-Aleem, Eman F Khaleel, Dalia G Mostafa, Lydia K Elberier
In the current study, we aimed to investigate the mechanistic role of DJ-1/PI3K/Akt survival pathway in ischemia/reperfusion (I/R) induced cerebral damage and to investigate if the resveratrol (RES) mediates its ischemic neuroptotection through this pathway. RES administration to Sham rats boosted glutathione level and superoxide dismutase activity and downregulated inducible nitric oxide synthase expression without affecting redox levels of DJ-1 forms or components of PI3K/Akt pathway including PTEN, p-Akt or p/p-GSK3b...
October 2016: Archives of Physiology and Biochemistry
Feyza Çelik, Muaz Belviranli, Nilsel Okudan
The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obese and non-obese women. The study included 83 women who were divided into four groups based on menopausal status and body mass index. The leptin level was significantly higher in the obese women than in the non-obese women (p < 0...
October 2016: Archives of Physiology and Biochemistry
Nouf Mohamed Al-Rasheed, Nawal Mohamed Al-Rasheed, Maha Abdelrahman Al-Amin, Iman Huesein Hasan, Hanaa Najeeb Al-Ajmi, Raeesa Ahmed Mohammad, Hala Aboulfotooh Attia
CONTEXT: Fibrates, the ligands of peroxisome profileferator-activated receptor-α have been shown to have a renal protective action in diabetic nephropathy (DN). OBJECTIVE: This study aimed to elucidate the effect of fenofibrate on renal transforming growth factor-β1 (TGF-β1) and Smad3 in Streptozotocin (STZ)-induced DN. METHODS: Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (55 mg/kg). Diabetic rats were given fenofibrate (100 mg/kg, p...
October 2016: Archives of Physiology and Biochemistry
Katarzyna Kuter, Manuela Kratochwil, Sven-Hendric Marx, Sonja Hartwig, Stephan Lehr, Michiru D Sugawa, Norbert A Dencher
Cause of Parkinson's disease (PD) is still not understood. Motor symptoms are not observed at early stages of disease due to compensatory processes. Dysfunction of mitochondria was indicated already at preclinical PD. Selective toxin 6-OHDA was applied to kill dopaminergic neurons in substantia nigra and disturb neuronal transmission in striatum. Early phase of active degeneration and later stage, when surviving cells adapted to function normally, were analysed. 2D BN/SDS difference gel electrophoresis (DIGE) of mitochondrial proteome enabled to point out crucial processes involved at both time-points in dopaminergic structures...
July 28, 2016: Archives of Physiology and Biochemistry
Suliman Al Humayed
AIM: We evaluated the potential preventive and therapeutic effects of Crataegus aronia (C. aronia) in NAFLD induced by high-fat diet (HFD) in rat models. METHODS: Protective effect of Crataegus aronia or simvastatin was investigated in Wistar rats fed either low-fat diet (LFD) or HFD. RESULTS: Liver histopathological examinations confirmed the development of NAFLD in rats fed HFD. In both protective and therapeutic treatments, C. aronia significantly reduced liver index (3...
July 16, 2016: Archives of Physiology and Biochemistry
Birgit Knebel, Susanne Mack, Stefan Lehr, Aiko Barsch, Martina Schiller, Jutta Haas, Simone Lange, Jens Fuchser, Gabriela Zurek, Dirk Müller-Wieland, Jorg Kotzka
Offspring of type 2 diabetes (T2D) patients have increased risk to develop diabetes, due to inherited genetic susceptibility that directly interferes with the individual adaption to environmental conditions. We characterise T2D offspring (OSP) to identify metabolic risk markers for early disease prediction. Plasma of metabolically healthy OSP individuals (n = 43) was investigated after an oral lipid tolerance test (oLTT) by an untargeted mass spectrometric approach for holistic metabolome analyses. Two subgroups of OSP probands can be separated by oLTT, although not differing in general clinical parameters...
July 2, 2016: Archives of Physiology and Biochemistry
Navneet Kumar, Pawan Kumar Maurya, Ruchi Kant, Syed Ibrahim Rizvi
CONTEXT: Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties. OBJECTIVE: The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects. METHODS: The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content...
July 2016: Archives of Physiology and Biochemistry
Abbas O El Karib, Bahjat Al-Ani, Fahaid Al-Hashem, Mohammad Dallak, Ismaeel Bin-Jaliah, Basiouny El-Gamal, Salah O Bashir, Refaat A Eid, Mohamed A Haidara
OBJECTIVE: Diabetic complications such as cardiovascular disease and osteoarthritis (OA) are among the common public health problems. The effect of insulin on OA secondary to diabetes has not been investigated before in animal models. Therefore, we sought to determine whether insulin and the insulin-mimicking agent, vanadium can protect from developing OA in diabetic rats. METHODS: Type 1 diabetes mellitus (T1DM) was induced in Sprague-Dawley rats and treated with insulin and/or vanadium...
July 2016: Archives of Physiology and Biochemistry
Antoaneta Gateva, Yavor Assyov, Adelina Tsakova, Zdravko Kamenov
OBJECTIVE: The soluble platelet secreted ligand CD40 (sCD40L) has a role in atherosclerosis progression. The aim of the present study was to investigate the link between the levels of sCD40L and some classical cardiovascular risk factors in obese nondiabetic patients. METHODS: In the present cross-sectional study, we included76 patients with mean age of 50.7 ± 10.7 years. Oral glucose tolerance test (OGTT) was performed in all participants and levels of sCD40L were measured using enzyme-linked immunosorbent assay (ELISA) method...
July 2016: Archives of Physiology and Biochemistry
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