Fernanda D'Avila da Silva, Maria Eduarda de Andrade Galiciolli, Ana Carolina Irioda, Cláudia Sirlene Oliveira, Bruna Candia Piccoli, Alessandro de Souza Prestes, Bruna Cogo Borin, Andre Passaglia Schuch, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, João Batista Teixeira da Rocha
JM-20 is a 1,5-benzodiazepine compound fused to a dihydropyridine fraction with different pharmacological properties. However, its potential toxic effects on blood cells have not yet been reported. Thus, the present study aimed to investigate, for the first time, the possible cytotoxicity of JM-20 through cell viability, cell cycle, morphology changes, reactive species (RS) to DCFH-DA, and lipid peroxidation in human leukocytes, its hemolytic effect on human erythrocytes, and its potential DNA genotoxicity using plasmid DNA in vitro...
January 19, 2024: Blood Cells, Molecules & Diseases