journal
MENU ▼
Read by QxMD icon Read
search

Journal of Receptor and Signal Transduction Research

journal
https://www.readbyqxmd.com/read/29199516/the-role-of-erk-and-smad2-signal-pathways-in-the-alternatively-activated-macrophages-induced-by-tgf-%C3%AE-1-and-high-ambient-glucose
#1
Ning Su, Chaoxing Xiao, Yi Wei, Qiuye Kou, Zongpei Jiang
Macrophages can be alternatively activated by TGF-β1 and high-ambient glucose, in which the role of Smad2 and the crosstalk between ERK and Smad2 pathways are not fully understood. The activation of ERK and Smad2 pathways and the expression of arginase-1 were detected by Western blot. The role of Smad2 and the relationship between ERK and Smad2 pathways were investigated by using biochemical inhibitors. The protein of arginase-1 was significantly overexpressed in RAW264.7 cells stimulated by TGF-β1 and high-ambient glucose, which can be partially blocked by not only U0126 (ERK inhibitor) but also SB431542 (Smad2 inhibitor)...
December 4, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29137494/trh-receptor-mobility-in-the-plasma-membrane-is-strongly-affected-by-agonist-binding-and-by-interaction-with-some-cognate-signaling-proteins
#2
Radka Moravcova, Barbora Melkes, Jiri Novotny
OBJECTIVES: Extensive research has been dedicated to elucidating the mechanisms of signal transduction through different G protein-coupled receptors (GPCRs). However, relatively little is known about the regulation of receptor movement within the cell membrane upon ligand binding. In this study we focused our attention on the thyrotropin-releasing hormone (TRH) receptor that typically couples to Gq/11 proteins. METHODS: We monitored receptor diffusion in the plasma membrane of HEK293 cells stably expressing yellow fluorescent protein (YFP)-tagged TRH receptor (TRHR-YFP) by fluorescence recovery after photobleaching (FRAP)...
November 14, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29041842/identifying-novel-small-molecule-antagonists-for-mlst8-protein-using-computational-approaches
#3
Tuleshwori Devi Sapam, Anbumani Velmurugan Ilavarasi, Bhagath Kumar Palaka, Elakkiya Elumalai, Nirmala Devi Kanika, Dinakara Rao Ampasala
Mammalian lethal with SEC13 protein 8 (mLST8), is an indispensable protein subunit of mammalian target of rapamycin (mTOR) signaling pathway that interacts with the kinase domain of mTOR protein, thereby stabilizing its active site. Experimental studies reported the over expression of mLST8 in human colon and prostate cancers by activation of both mTORC1/2 complexes and subsequent downstream substrates leading to tumor progression. Considering its role, targeting mLST8 protein would be a therapeutic approach against tumor progression in colon and prostate cancers...
October 17, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29041840/identification-of-novel-scaffolds-to-inhibit-human-mitotic-kinesin-eg5-targeting-the-second-allosteric-binding-site-using-in-silico-methods
#4
Himesh Makala, Venkatasubramanian Ulaganathan
Human mitotic kinesins are potential anticancer drug targets because of their essential role in mitotic cell division. The kinesin Eg5 (Kinesin-5, kif11) has gained much attention in this regard and has many inhibitors in different phases of clinical trials. All drug candidates considered for Eg5 so far binds to the binding site (Site 1) formed by the loop L5, helices α2 and α3 and are uncompetitive to ATP/ADP. Recently, it has been reported that Eg5 also has a second binding site (Site 2) formed by helices α4 and α6...
October 17, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28958213/ligand-based-virtual-screening-molecular-docking-qsar-and-pharmacophore-analysis-of-quercetin-associated-potential-novel-analogs-against-epidermal-growth-factor-receptor
#5
Uma Devi Bommu, Kranthi Kumar Konidala, Neeraja Pabbaraju, Suneetha Yeguvapalli
The present study was to explore expectation and examination of therapeutic potential quercetin analogs as efficient anticancer agents against human epidermal growth factor receptor (EGFR), which is a consistent hallmark for moderating the non-small-cell lung carcinoma (NSCLC). Here, ligand-based virtual screening, pharmacophore approach and molecular docking were established as rational strategies for recognition of small analogs against the ligand binding domain of EGFR (PDB code: 1XKK). Adverse effects, toxicogenomics and pharmacokinetics reported that 10 candidates showed reliable consequences with less side effects and more efficient for target receptor...
December 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812970/indole-3-carbinol-induces-g1-cell-cycle-arrest-and-apoptosis-through-aryl-hydrocarbon-receptor-in-thp-1-monocytic-cell-line
#6
Saeed Mohammadi, Fakhri Sadat Seyedhosseini, Nasser Behnampour, Yaghoub Yazdani
OBJECTIVES: The role of aryl hydrocarbon receptor (AhR) in carcinogenesis has been studied recently. Indole-3-carbinol (I3C) is an AhR agonist and a potential anticancer agent. Here, we investigated the effects of I3C on cell cycle progression and apoptosis through activation of AhR on THP-1 acute myeloid leukemia (AML) cell line. METHODS: MTT viability assay was used to measure the cytotoxic effects of I3C on THP-1 cells. Apoptosis and cell cycle assays were investigated using flow cytometry...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812969/functional-expression-of-bmp7-receptors-in-oral-epithelial-cells-interleukin-17f-production-in-response-to-bmp7
#7
Kensuke Nishio, Yasumasa Ozawa, Hisanori Ito, Takashi Kifune, Tatsuya Narita, Toshimitsu Iinuma, Nobuhito Gionhaku, Masatake Asano
BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. Recently, BMP7 has been demonstrated to be produced by salivary glands and contribute to embryonic branching in mice. The BMP7 in saliva is thought to be delivered to the oral cavity and is expected to contact with stratified squamous epithelial cells which line the surface of oral mucosa. In this study, we attempted to investigate the effects of BMP7 on oral epithelial cells...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812968/jnk-pathway-in-osteoarthritis-pathological-and-therapeutic-aspects
#8
Hong-Xing Ge, Fu-Man Zou, Yan Li, An-Min Liu, Min Tu
CONTEXT: Osteoarthritis (OA) is a common chronic degenerative joint disease resulting in physical disability and reduced quality of life. Different biochemical signaling pathways are involved in the progression of OA, including the c-Jun NH2-terminal kinase (JNK) signal transduction pathway. OBJECTIVE: In this study, we have reviewed the recent updates on the association of JNK pathway with OA. METHODS: In this review, we have explored the databases like PubMed, Google Scholar, Medline, Scopus, etc...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812967/tanshinone-induced-ers-suppresses-igfii-activation-to-alleviate-ang-ii-mediated-cardiac-hypertrophy
#9
Ya-Fang Chen, Nien-Hung Lee, Pei-Ying Pai, Li-Chin Chung, Chia-Yao Shen, Peramaiyan Rajendran, Yu-Feng Chen, Ray-Jade Chen, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Cardiomyopathy involves changes in myocardial ultrastructure and cardiac hypertrophy. Angiotensin II (AngII) has previously been shown to stimulate the expression of IGF-2 and IGF-2R in H9c2 cardiomyoblasts and increase of blood pressure, and cardiac hypertrophy. Estrogen receptors (ERs) exert protective effects, such as anti-hypertrophy in cadiomyocytes. Tanshinone IIA (TSN), a main active ingredient from a Chinese medical herb, Salvia miltiorrhiza Bunge (Danshen), was shown to protect cardiomyocytes hypertrophy by different stress signals...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28770648/effect-of-uric-acid-on-inflammatory-cox-2-and-ros-pathways-in-vascular-smooth-muscle-cells
#10
Nurgül Oğuz, Mustafa Kırça, Arzu Çetin, Akın Yeşilkaya
Hyperuricemia is thought to play a role in cardiovascular diseases (CVD), including hypertension, coronary artery disease and atherosclerosis. However, exactly how uric acid contributes to these pathologies is unknown. An underlying mechanism of inflammatory diseases, such as atherosclerosis, includes enhanced production of cyclooxygenase-2 (COX-2) and superoxide anion. Here, we aimed to examine the effect of uric acid on inflammatory COX-2 and superoxide anion production and to determine the role of losartan...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28768454/insight-into-the-structural-requirements-of-thiophene-3-carbonitriles-based-murf-inhibitors-by-3d-qsar-molecular-docking-and-molecular-dynamics-study
#11
Mohammed Afzal Azam, Srikanth Jupudi
The discovery of clinically relevant inhibitors against MurF enzyme has proven to be a challenging task. In order to get further insight into the structural features required for the MurF inhibitory activity, we performed pharmacophore and atom-based three-dimensional quantitative structure-activity relationship studies for novel thiophene-3-carbonitriles based MurF inhibitors. The five-feature pharmacophore model was generated using 48 inhibitors having IC50 values ranging from 0.18 to 663 μm. The best-fitted model showed a higher coefficient of determination (R(2) = 0...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28758854/3d-qsar-pharmacophore-based-virtual-screening-molecular-docking-and-molecular-dynamics-simulation-toward-identifying-lead-compounds-for-ns2b-ns3-protease-inhibitors
#12
Pei H Luo, Xuan R Zhang, Lan Huang, Lun Yuan, Xang Z Zhou, X Gao, Ling S Li
NS2B-NS3 protease has been identified to serve as lead drug design target due to its significant role in West Nile viral (WNV) and dengue virus (DENV) reproduction and replication. There are currently no approved chemotherapeutic drugs and effective vaccines to inhibit DENV and WNV infections. In this work, 3D-QSAR pharmacophore model has been developed to discover potential inhibitory candidates. Validation through Fischer's model and decoy test indicate that the developed 3D pharmacophore model is highly predictive for DENV inhibitors, which was then employed to screen ZINC chemical library to obtain reasonable hits...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28758826/implication-of-sphingosine-1-phosphate-signaling-in-diseases-molecular-mechanism-and-therapeutic-strategies
#13
Mohd Arish, Mohammed Alaidarous, Rahat Ali, Yusuf Akhter, Abdur Rub
Sphingosine-1-phosphate signaling is emerging as a critical regulator of cellular processes that is initiated by the intracellular production of bioactive lipid molecule, sphingosine-1-phosphate. Binding of sphingosine-1-phosphate to its extracellular receptors activates diverse downstream signaling that play a critical role in governing physiological processes. Increasing evidence suggests that this signaling pathway often gets impaired during pathophysiological and diseased conditions and hence manipulation of this signaling pathway may be beneficial in providing treatment...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28670936/identification-and-characterization-of-erbb4-kinase-inhibitors-for-effective-breast-cancer-therapy
#14
Ankita Sahu, P K Patra, Manoj Kumar Yadav, Meena Varma
The overexpression of ErbB4 is associated with aggressive disease biology and reduced the survival of breast cancer patients. We have used ErbB4 receptor as a novel drug target to spearhead the rational drug design. The present study is divided into two parts. In the first part, we have exploited the hidden information inside ErbB4 kinase receptor both at sequence and structural level. PSI-BLAST algorithm is used to search similar sequences against ErbB4 kinase sequence. Top 15 sequences with high identity were selected for finding conserved and variable regions among sequences using multiple sequence alignment...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28553881/the-relationship-between-levels-of-plasma-soluble-urokinase-plasminogen-activator-receptor-supar-and-presence-of-migraine-attack-and-aura
#15
Nigar Yılmaz, Mustafa Yılmaz, Burcu Sirin, Sureyya Yılmaztekin, Gülnihal Kutlu
Migraine is one of the most common types of pain associated with sterile inflammatory conditions. Soluble urokinase plasminogen activator receptor (suPAR) is a potential novel inflammatory marker. We aim to determine the association between serum values of suPAR, procalcitonin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) and migraine disease characteristics. The study involved a total of 60 migraine patients (33 patients in the interictal period, 27 patients in the attack period) and 30 healthy individuals...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28537140/molecular-modeling-driven-approach-for-identification-of-janus-kinase-1-inhibitors-through-3d-qsar-docking-and-molecular-dynamics-simulations
#16
Ramesh Itteboina, Srilata Ballu, Sree Kanth Sivan, Vijjulatha Manga
Janus kinase 1 (JAK 1) belongs to the JAK family of intracellular nonreceptor tyrosine kinase. JAK-signal transducer and activator of transcription (JAK-STAT) pathway mediate signaling by cytokines, which control survival, proliferation and differentiation of a variety of cells. Three-dimensional quantitative structure activity relationship (3 D-QSAR), molecular docking and molecular dynamics (MD) methods was carried out on a dataset of Janus kinase 1(JAK 1) inhibitors. Ligands were constructed and docked into the active site of protein using GLIDE 5...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28856943/probing-voltage-sensing-domain-of-kcnq2-channel-as-a-potential-target-to-combat-epilepsy-a-comparative-study
#17
Pakhuri Mehta, Shubham Srivastava, Bhanwar Singh Choudhary, Manish Sharma, Ruchi Malik
Multidrug resistance along with side-effects of available anti-epileptic drugs and unavailability of potent and effective agents in submicromolar quantities presents the biggest therapeutic challenges in anti-epileptic drug discovery. The molecular modeling techniques allow us to identify agents with novel structures to match the continuous urge for its discovery. KCNQ2 channel represents one of the validated targets for its therapy. The present study involves identification of newer anti-epileptic agents by means of a computer-aided drug design adaptive protocol involving both structure-based virtual screening of Asinex library using homology model of KCNQ2 and 3D-QSAR based virtual screening with docking analysis, followed by dG bind and ligand efficiency calculations with ADMET studies, of which 20 hits qualified all the criterions...
August 31, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28854843/a-bioluminescence-resonance-energy-transfer-2-bret2-assay-for-monitoring-seven-transmembrane-receptor-and-insulin-receptor-crosstalk
#18
Samra Joke Sanni, Nikolaj Kulahin, Rasmus Jorgensen, Christina Lyngsø, Steen Gammeltoft, Jakob Lerche Hansen
The angiotensin AT1 receptor is a seven transmembrane (7TM) receptor, which mediates the regulation of blood pressure. Activation of angiotensin AT1 receptor may lead to impaired insulin signaling indicating crosstalk between angiotensin AT1 receptor and insulin receptor signaling pathways. To elucidate the molecular mechanisms behind this crosstalk, we applied the BRET(2) technique to monitor the effect of angiotensin II on the interaction between Rluc(8) tagged insulin receptor and GFP(2) tagged insulin receptor substrates 1, 4, 5 (IRS1, IRS4, IRS5) and Src homology 2 domain-containing protein (Shc)...
August 30, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28853308/insulin-suppresses-mpp-induced-neurotoxicity-by-targeting-integrins-and-syndecans-in-c6-astrocytes
#19
Mahesh Ramalingam, Mi Hyun Cheng, Sung-Jin Kim
Parkinson's disease (PD) is the second most common neurodegenerative disease in the elderly. In central nervous system, astrocytes regulates neuronal function via the modulation of synaptic transmission and plasticity, secretion of growth factors, uptake of neurotransmitters and regulation of extracellular ion concentrations and metabolic support of neurons. Therefore, C6 astroglial cells have been used to study the in vitro PD model induced by 1-methyl-4-phenyl pyridinium (MPP(+)). In this study, pre-treatment of insulin inhibited MPP(+)-induced cell membrane damages on LDH and NO releases, which also inhibited the iNOS and Cox-2 levels...
August 30, 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28849985/synergic-prooxidant-apoptotic-and-trpv1-channel-activator-effects-of-alpha-lipoic-acid-and-cisplatin-in-mcf-7-breast-cancer-cells
#20
Gökhan Nur, Mustafa Nazıroğlu, Haci Ahmet Deveci
BACKGROUND: Resistance to cisplatin (Cisp) in the treatment of breast cancer is a major obstacle. Alpha-lipoic acid (ALA) has both antioxidant and oxidant properties. ALA has been used on stimulation mechanisms of apoptosis and oxidative stress in the treatment of cancer with a combination of chemotherapeutic agents, although its role on molecular mechanisms in the cancer cells has not been clarified yet. The aim of this study was to evaluate if a combination therapy of ALA with Cisp can alter the effect of this chemotherapy drug in the MCF-7 breast cancer cells...
August 29, 2017: Journal of Receptor and Signal Transduction Research
journal
journal
32308
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"