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Multiple Sclerosis: Clinical and Laboratory Research

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https://www.readbyqxmd.com/read/28090800/similar-familial-risk-in-multiple-sclerosis-subgroups
#1
Jie Song, Virginija Karrenbauer, Ali Manouchehrinia, Catarina Almqvist, Jan Hillert, Helga Westerlind
BACKGROUND: A subgroup of patients diagnosed with multiple sclerosis (MS) present with no oligoclonal bands (OCB) in the cerebrospinal fluid (CSF). Several studies report different clinical characteristics and genetic associations between the two groups. OBJECTIVE: To investigate whether the OCB negative subgroup has a distinct etiology from band positive MS. METHODS: Using nationwide registers to estimate familial risks, which reflect the genetic contribution of a disease...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28090798/switching-from-branded-to-generic-glatiramer-acetate-15-month-gate-trial-extension-results
#2
Krzysztof Selmaj, Frederik Barkhof, Anna N Belova, Christian Wolf, Evelyn Rw van den Tweel, Janine Jl Oberyé, Roel Mulder, David F Egging, Norbert P Koper, Jeffrey A Cohen
BACKGROUND: Open-label 15-month follow-up of the double-blind, placebo-controlled Glatiramer Acetate clinical Trial to assess Equivalence with Copaxone(®) (GATE) trial. OBJECTIVE: To evaluate efficacy, safety, and tolerability of prolonged generic glatiramer acetate (GTR) treatment and to evaluate efficacy, safety, and tolerability of switching from brand glatiramer acetate (GA) to GTR treatment. METHODS: A total of 729 patients received GTR 20 mg/mL daily...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28086035/hippocampal-dysfunction-is-associated-with-memory-impairment-in-multiple-sclerosis-a-volumetric-and-functional-connectivity-study
#3
Julio Alberto González Torre, Álvaro Javier Cruz-Gómez, Antonio Belenguer, Carla Sanchis-Segura, César Ávila, Cristina Forn
BACKGROUND: Previous studies have suggested a relationship between neuroanatomical and neurofunctional hippocampal alterations and episodic memory impairments in multiple sclerosis (MS) patients. OBJECTIVE: We examined hippocampus volume and functional connectivity (FC) changes in MS patients with different episodic memory capabilities. METHODS: Hippocampal subfield volume and FC changes were compared in two subgroups of MS patients with and without episodic memory impairment (multiple sclerosis impaired (MSi) and multiple sclerosis preserved (MSp), respectively) and healthy controls (HC)...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28086032/liver-injury-associated-with-dimethyl-fumarate-in-multiple-sclerosis-patients
#4
Monica A Muñoz, Corrinne G Kulick, Cindy M Kortepeter, Robert L Levin, Mark I Avigan
BACKGROUND: In pre-approval trials, there was an increased incidence of mild, transient elevations of liver aminotransferases in study subjects treated with dimethyl fumarate (DMF). OBJECTIVE/METHODS: To evaluate post-marketing cases of drug-induced liver injury associated with DMF. RESULTS: We identified 14 post-marketing cases of clinically significant liver injury. Findings included newly elevated serum liver aminotransferase and bilirubin levels that developed as early as a few days after the first dose of DMF...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080262/processing-speed-test-validation-of-a-self-administered-ipad-%C3%A2-based-tool-for-screening-cognitive-dysfunction-in-a-clinic-setting
#5
Stephen M Rao, Genna Losinski, Lyla Mourany, David Schindler, Bernadett Mamone, Christine Reece, Danielle Kemeny, Sridar Narayanan, Deborah M Miller, Francois Bethoux, Robert A Bermel, Richard Rudick, Jay Alberts
BACKGROUND: Cognitive dysfunction is common in multiple sclerosis (MS) patients and has important consequences for daily activities, yet, unlike motor function, is not routinely assessed in the clinic setting. We developed the Processing Speed Test (PST), a self-administered iPad(®)-based tool to measure MS-related deficits in processing speed. OBJECTIVE: To determine whether the PST is valid for screening cognitive dysfunction by comparing it to the paper-and-pencil Symbol Digit Modalities Test (SDMT)...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080255/assessing-long-term-prognosis-improvement-as-a-consequence-of-treatment-pattern-changes-in-ms
#6
Ruggero Capra, Cinzia Cordioli, Sarah Rasia, Fabio Gallo, Alessio Signori, Maria Pia Sormani
OBJECTIVE: To assess whether the age at which multiple sclerosis (MS) patients reach Expanded Disability Status Scale (EDSS) milestones changed as long as new drugs for the treatment of MS became available. METHODS: We evaluated the long-term impact of therapies on disability progression assessing whether there is a detectable delay in the age at which patients reached EDSS milestones in more recent years. We used data collected over more than 30 years in the Center of Brescia, Italy...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080254/wellness-and-multiple-sclerosis-the-national-ms-society-establishes-a-wellness-research-working-group-and-research-priorities
#7
Robert W Motl, Ellen M Mowry, Dawn M Ehde, Nicholas G LaRocca, Kathy E Smith, Kathleen Costello, Lynne Shinto, Alexander V Ng, Amy B Sullivan, Barbara Giesser, Kevin K McCully, Bo Fernhall, Malachy Bishop, Matthew Plow, Patrizia Casaccia, Nancy D Chiaravalloti
BACKGROUND: People with multiple sclerosis (MS) have identified "wellness" and associated behaviors as a high priority based on "social media listening" undertaken by the National MS Society (i.e. the Society). OBJECTIVE: The Society recently convened a group that consisted of researchers with experience in MS and wellness-related research, Society staff members, and an individual with MS for developing recommendations regarding a wellness research agenda. METHOD: The members of the group engaged in focal reviews and discussions involving the state of science within three approaches for promoting wellness in MS, namely diet, exercise, and emotional wellness...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080220/predictors-of-response-to-first-line-immunosuppressive-therapy-in-neuromyelitis-optica-spectrum-disorders
#8
Su-Hyun Kim, Jae-Won Hyun, AeRan Joung, Eun Young Park, Jungnam Joo, Ho Jin Kim
BACKGROUND: Azathioprine (AZA) and mycophenolate mofetil (MMF) are the most commonly used first-line therapies for patients with neuromyelitis optica spectrum disorders (NMOSD). However, some patients experience a relapse following AZA or MMF treatment. OBJECTIVES: To identify factors that predict a response to AZA or MMF in NMOSD. METHODS: We retrospectively evaluated medical records from 116 patients who were initially treated with AZA or MMF for at least 6 months...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080218/temperature-dependence-of-multiple-sclerosis-mortality-rates-in-the-united-states
#9
Hongbing Sun
BACKGROUND: It is well known that multiple sclerosis (MS) patients are very sensitive to heat events. However, how MS patients respond to the significant temperature difference between the high- and low-latitude regions is not understood. OBJECTIVE: The goal is to identify the primary factor responsible for the fact that MS mortality rates of the United States is more than three times higher in the northern states than in the southern states. METHODS: Correlation coefficients between the age-adjusted mortality rate of MS as the underlying cause of death and the state average temperature, altitude, latitude, duration of sunshine hours, and solar radiation in the 48 contiguous states were compared...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28080211/neuromyelitis-optica-spectrum-disorder-diagnostic-criteria-sensitivity-and-specificity-are-both-important
#10
Dean M Wingerchuk, Brian G Weinshenker
No abstract text is available yet for this article.
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28068191/pactrims-2016
#11
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28067603/protective-personality-traits-high-openness-and-low-neuroticism-linked-to-better-memory-in-multiple-sclerosis
#12
Victoria M Leavitt, Korhan Buyukturkoglu, Matilde Inglese, James F Sumowski
BACKGROUND: Memory impairment in multiple sclerosis (MS) is common, although few risk/protective factors are known. OBJECTIVE: To examine relationships of personality to memory/non-memory cognition in MS. METHOD: 80 patients completed a cognitive battery and a personality scale measuring the "Big 5" traits: openness, neuroticism, agreeableness, extraversion, and conscientiousness. RESULTS: Memory was most related to openness, with higher openness linked to better memory and lower risk for memory impairment, controlling for age, atrophy, education, and intelligence quotient (IQ)...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28067602/mirnas-in-cerebrospinal-fluid-identify-patients-with-ms-and-specifically-those-with-lipid-specific-oligoclonal-igm-bands
#13
Ester Quintana, Francisco José Ortega, René Robles-Cedeño, María Luisa Villar, Maria Buxó, Josep Maria Mercader, José Carlos Alvarez-Cermeño, Neus Pueyo, Héctor Perkal, José Manuel Fernández-Real, Lluís Ramió-Torrentà
BACKGROUND: MicroRNAs (miRNAs) are non-coding RNAs that regulate cellular processes by controlling protein translation and mRNA degradation. OBJECTIVE: We aimed to explore the miRNA signature of multiple sclerosis (MS) patients versus controls and the possibility that patients with lipid-specific oligolconal IgM bands (LS_OCMB), a predictor of a more severe disease course, may have a distinct profile. METHODS: An extensive profile of 754 miRNAs was evaluated in the cerebrospinal fluid (CSF) of 14 women using TaqMan low-density arrays...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28067584/short-segment-myelitis-as-a-first-manifestation-of-neuromyelitis-optica-spectrum-disorders
#14
So-Young Huh, Su-Hyun Kim, Jae-Won Hyun, In Hye Jeong, Min Su Park, Sang-Hyun Lee, Ho Jin Kim
BACKGROUND: Some patients with neuromyelitis optica spectrum disorders (NMOSD) present with spinal cord lesions extending fewer than three vertebral segments (short transverse myelitis, STM), hindering an early diagnosis. OBJECTIVE: We investigated the frequency and imaging characteristics of STM lesions in patients presenting with myelitis as an initial manifestation of NMOSD. METHODS: Patients seen at three referral hospitals in Korea between June 2005 and March 2015 who met the following inclusion criteria were recruited for review: seropositivity for aquaporin-4 antibody, initial presentation with myelitis and spinal cord magnetic resonance imaging (MRI) performed within 1 month of initial myelitis onset...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28059618/smokers-with-ms-have-greater-decrements-in-quality-of-life-and-disability-than-non-smokers
#15
Farren Bs Briggs, Douglas D Gunzler, Daniel Ontaneda, Ruth Ann Marrie
BACKGROUND: Tobacco smoke plays a pathogenic role in multiple sclerosis (MS) and may accelerate disease progression, yet, some people with MS continue to smoke after disease onset. The average smoker reports diminished health-related quality of life (HRQOL) across many populations. OBJECTIVES: To describe the relationships between smoking status and HRQOL, disease activity, and global disability in a US population with MS. METHODS: We compared smokers to non-smokers in 950 responders to the Spring 2014 update survey completed by North American Research Committee on Multiple Sclerosis (NARCOMS) registry participants...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28058965/clinical-characteristics-of-late-onset-neuromyelitis-optica-spectrum-disorder-a-multicenter-retrospective-study-in-korea
#16
Jin Myoung Seok, Hye-Jin Cho, Suk-Won Ahn, Eun Bin Cho, Min Su Park, In-Soo Joo, Ha Young Shin, Sun-Young Kim, Byung-Jo Kim, Jong Kuk Kim, Joong-Yang Cho, So-Young Huh, Ohyun Kwon, Kwang-Ho Lee, Byoung Joon Kim, Ju-Hong Min
BACKGROUND: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). OBJECTIVE: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. METHODS: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset)...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27956560/marta-elian-obituary
#17
Michael Hutchinson
No abstract text is available yet for this article.
December 12, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27956559/clinical-course-of-multiple-sclerosis-a-nationwide-cohort-study
#18
Ali Manouchehrinia, Omid Beiki, Jan Hillert
BACKGROUND: The course of multiple sclerosis (MS) has been studied in several cohorts; however, results have varied significantly. OBJECTIVE: To describe the clinical course of MS in a nationwide cohort of patients. METHOD: Data from the Swedish MS register (SMSreg) were used to estimate the median time to the sustained Expanded Disability Status Scale (EDSS) scores 3.0, 4.0 and 6.0, onset of secondary progressive multiple sclerosis (SPMS) and death using Kaplan-Meier method...
December 12, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27956558/erratum
#19
(no author information available yet)
Lisak RP and Dhib-Jalbut S. Obituary-Omar Khan, MD, Professor and Chair of Neurology and Neurologist-in-Chief of the Detroit Medical Center. Mult Scler 2016; 22: 1385. DOI: 10.1177/1352458516669864.
December 12, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27956557/breaking-down-the-gut-microbiome-composition-in-multiple-sclerosis
#20
REVIEW
Adrian Budhram, Seema Parvathy, Marcelo Kremenchutzky, Michael Silverman
BACKGROUND: The gut microbiome, which consists of a highly diverse ecologic community of micro-organisms, has increasingly been studied regarding its role in multiple sclerosis (MS) immunopathogenesis. This review critically examines the literature investigating the gut microbiome in MS. METHODS: A comprehensive search was performed of PubMed databases and ECTRIMS meeting abstracts for literature relating to the gut microbiome in MS. Controlled studies examining the gut microbiome in patients with MS were included for review...
December 12, 2016: Multiple Sclerosis: Clinical and Laboratory Research
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