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Multiple Sclerosis: Clinical and Laboratory Research

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https://www.readbyqxmd.com/read/29327668/impact-of-3-tesla-mri-on-interobserver-agreement-in-clinically-isolated-syndrome-a-magnims-multicentre-study
#1
Marloes Hj Hagens, Jessica Burggraaff, Iris D Kilsdonk, Serena Ruggieri, Sara Collorone, Rosa Cortese, Niamh Cawley, Emilia Sbardella, Michaela Andelova, Michael Amann, Johanna M Lieb, Patrizia Pantano, Birgit I Lissenberg-Witte, Joep Killestein, Celia Oreja-Guevara, Jens Wuerfel, Olga Ciccarelli, Claudio Gasperini, Carsten Lukas, Alex Rovira, Frederik Barkhof, Mike P Wattjes
BACKGROUND: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. OBJECTIVES: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. METHODS: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29320952/fatty-acid-binding-protein-4-is-associated-with-disability-in-multiple-sclerosis-patients
#2
Riley Bove, Brain C Healy, Alexander Musallam, Pejvak Soltany, Camilo Diaz-Cruz, Neda Sattarnezhad, Bonnie I Glanz, Pia Kivisäkk, Karen K Miller, Tanuja Chitnis
BACKGROUND: Increased adiposity is a risk factor for multiple sclerosis (MS) and is associated with increased disability scores. Adipokines may mediate the effects of adiposity on MS disease course. OBJECTIVE: The objective of this study is to examine the association between the adipokines (leptin and fatty acid binding protein-4, FABP4) and clinical course in individuals with MS. METHODS: Subjects (18-65 years) with relapsing-remitting MS or clinically isolated syndrome and <10 year disease duration were selected from a longitudinal clinical study...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29320933/gray-matter-networks-and-cognitive-impairment-in-multiple-sclerosis
#3
Carolina M Rimkus, Menno M Schoonheim, Martijn D Steenwijk, Hugo Vrenken, Anand Jc Eijlers, Joep Killestein, Mike P Wattjes, Claudia C Leite, Frederik Barkhof, Betty M Tijms
BACKGROUND: Coordinated patterns of gray matter morphology can be represented as networks, and network disruptions may explain cognitive dysfunction related to multiple sclerosis (MS). OBJECTIVE: To investigate whether single-subject gray matter network properties are related to impaired cognition in MS. METHODS: We studied 148 MS patients (99 female) and 33 healthy controls (HC, 21 female). Seven network parameters were computed and compared within MS between cognitively normal and impaired subjects, and associated with performance on neuropsychological tests in six cognitive domains with regression models...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29318936/-brain-reserve-and-cognitive-reserve-should-always-be-taken-into-account-when-studying-neurodegeneration-commentary
#4
Maria Pia Amato
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29318923/-brain-reserve-and-cognitive-reserve-should-always-be-taken-into-account-when-studying-neurodegeneration-yes
#5
James F Sumowski
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29318919/-brain-reserve-and-cognitive-reserve-should-always-be-taken-into-account-when-studying-neurodegeneration-no
#6
Jaume Sastre-Garriga
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29310500/do-spinal-cord-lesions-matter-in-patients-with-clinically-isolated-syndrome-and-early-ms
#7
Wallace J Brownlee
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29310490/harnessing-electronic-medical-records-to-advance-research-on-multiple-sclerosis
#8
Vincent Damotte, Antoine Lizée, Matthew Tremblay, Alisha Agrawal, Pouya Khankhanian, Adam Santaniello, Refujia Gomez, Robin Lincoln, Wendy Tang, Tiffany Chen, Nelson Lee, Pablo Villoslada, Jill A Hollenbach, Carolyn D Bevan, Jennifer Graves, Riley Bove, Douglas S Goodin, Ari J Green, Sergio E Baranzini, Bruce Ac Cree, Roland G Henry, Stephen L Hauser, Jeffrey M Gelfand, Pierre-Antoine Gourraud
BACKGROUND: Electronic medical records (EMR) data are increasingly used in research, but no studies have yet evaluated similarity between EMR and research-quality data and between characteristics of an EMR multiple sclerosis (MS) population and known natural MS history. OBJECTIVES: To (1) identify MS patients in an EMR system and extract clinical data, (2) compare EMR-extracted data with gold-standard research data, and (3) compare EMR MS population characteristics to expected MS natural history...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29308979/response-to-does-cladribine-have-an-impact-on-brain-atrophy-in-people-with-relapsing-remitting-multiple-sclerosis-by-schiffmann-et-al
#9
Nicola De Stefano, Antonio Giorgio
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29308975/does-cladribine-have-an-impact-on-brain-atrophy-in-people-with-relapsing-remitting-multiple-sclerosis
#10
Insa Schiffmann, Jutta Scheiderbauer, Karin Riemann-Lorenz, Christoph Heesen
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29303040/genetic-basis-for-relapse-rate-in-multiple-sclerosis-association-with-lrp2-genetic-variation
#11
Kelly Hilven, Marijne Vandebergh, Ide Smets, Klara Mallants, An Goris, Bénédicte Dubois
BACKGROUND: In contrast to successes for multiple sclerosis (MS) susceptibility, the genetic basis for clinical heterogeneity remains largely unresolved. OBJECTIVES: We investigate the first reported genetic association with relapse rate. METHODS: We genotyped variant rs12988804 in LRP2 in a homogeneous study population of 527 Belgian MS patients with 970 documented relapses. RESULTS: The rs12988804*T allele is associated with a 1...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29303036/cognitive-reserve-cognition-and-regional-brain-damage-in-ms-a-2%C3%A2-year-longitudinal-study
#12
Maria Assunta Rocca, Gianna C Riccitelli, Alessandro Meani, Elisabetta Pagani, Paola Del Sette, Vittorio Martinelli, Giancarlo Comi, Andrea Falini, Massimo Filippi
BACKGROUND: According to the cognitive reserve (CR) theory, enriching experiences protect against cognitive decline. OBJECTIVES: To investigate the dynamic interaction between CR and global/regional measures of brain white matter (WM) and gray matter (GM) damage and their effect on cognitive performance in multiple sclerosis (MS). METHODS: Baseline and 2 -year three-dimensional (3D) T1-weighted scans were obtained from 54 MS patients and 20 healthy controls...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29303033/optical-coherence-tomography-angiography-indicates-associations-of-the-retinal-vascular-network-and-disease-activity-in-multiple-sclerosis
#13
Nikolaus Feucht, Mathias Maier, Gildas Lepennetier, Moritz Pettenkofer, Carmen Wetzlmair, Tanja Daltrozzo, Pauline Scherm, Claus Zimmer, Muna-Miriam Hoshi, Bernhard Hemmer, Thomas Korn, Benjamin Knier
BACKGROUND: Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS. OBJECTIVE: To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity. METHOD: In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomography angiography (OCT-A) with analysis of the superficial and deep vascular plexuses and the choriocapillaries...
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29303028/inner-ear-involvement-in-multiple-sclerosis-an-underestimated-condition
#14
Arianna Di Stadio, Massimo Ralli
No abstract text is available yet for this article.
January 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29260609/test-retest-agreement-and-reliability-of-the-six-spot-step-test-in-persons-with-multiple-sclerosis
#15
Jacob Callesen, Christina Richter, Cecilie Kristensen, Inger Sunesen, Marie Næsby, Ulrik Dalgas, Anders Guldhammer Skjerbæk
BACKGROUND: The Six Spot Step Test (SSST) extends traditional walking outcomes in persons with multiple sclerosis (PwMS) by further challenging components of coordination and balance. Nonetheless, the test-retest agreement of the SSST has not been investigated. OBJECTIVE: To determine the within-day, day-to-day, and inter-rater agreement and reliability of the SSST in PwMS. A secondary aim was to investigate the validity of handheld timing. METHODS: A total of 38 PwMS with an Expanded Disability Status Scale (EDSS) <6...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29254434/fair-data-for-next-generation-management-of-multiple-sclerosis
#16
Liesbet M Peeters
Multiple sclerosis (MS) is a progressive demyelinating and degenerative disease of the central nervous system with symptoms depending on the disease type and the site of lesions and is featured by heterogeneity of clinical expressions and responses to treatment strategies. An individualized clinical follow-up and multidisciplinary treatment is required. Transforming the population-based management of today into an individualized, personalized and precision-level management is a major goal in research. Indeed, a complex and unique interplay between genetic background and environmental exposure in each case likely determines clinical heterogeneity...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29251250/the-era-of-gwas-is-over-yes
#17
Koen Vandenbroeck
No abstract text is available yet for this article.
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29251224/corrigendum
#18
(no author information available yet)
Dekker I, Sombekke, MH, Birgit, IW, et al. Asymptomatic spinal cord lesions do not predict the time to disability in patients with early multiple sclerosis. Mult Scler. Epub ahead of print 6 November 2017. DOI: 10.1177/1352458517736147. In the initial Online First version of this article, the Funding statement was incomplete. The correct statement is below: Funding The author(s) declared receipt of the following financial support for the research, authorship and/or publication of this article: The MS Centre Amsterdam is supported by the Dutch MS Research Foundation (grant number 14-358e)...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29251183/the-era-of-gwas-is-over-commentary
#19
Sergio E Baranzini
No abstract text is available yet for this article.
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29251117/the-era-of-gwas-is-over-no
#20
Philip L De Jager
No abstract text is available yet for this article.
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
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