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Multiple Sclerosis: Clinical and Laboratory Research

journal
https://www.readbyqxmd.com/read/30234433/treatment-decisions-in-ms-shifting-the-goal-posts-or-changing-how-we-see-them
#1
Kedar R Mahajan, Kunio Nakamura, Daniel Ontaneda
No abstract text is available yet for this article.
September 20, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30234431/silent-lesions-on-mri-imaging-shifting-goal-posts-for-treatment-decisions-in-multiple-sclerosis
#2
Myintzu Min, Tim Spelman, Alessandra Lugaresi, Cavit Boz, Daniele LA Spitaleri, Eugenio Pucci, Francois Grand'Maison, Franco Granella, Guillermo Izquierdo, Helmut Butzkueven, Jose Luis Sanchez-Menoyo, Michael Barnett, Marc Girard, Maria Trojano, Pierre Grammond, Pierre Duquette, Patrizia Sola, Raed Alroughani, Raymond Hupperts, Steve Vucic, Tomas Kalincik, Vincent Van Pesch, Jeannette Lechner-Scott
BACKGROUND: The current best practice suggests yearly magnetic resonance imaging (MRI) to monitor treatment response in multiple sclerosis (MS) patients. OBJECTIVE: To evaluate the current practice of clinicians changing MS treatment based on subclinical new MRI lesions alone. METHODS: Using MSBase, an international MS patient registry with MRI data, we analysed the probability of treatment change among patients with clinically silent new MRI lesions...
September 20, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30231004/e-health-and-multiple-sclerosis-an-update
#3
Luigi Lavorgna, Francesco Brigo, Marcello Moccia, Letizia Leocani, Roberta Lanzillo, Marinella Clerico, Gianmarco Abbadessa, Klaus Schmierer, Claudio Solaro, Luca Prosperini, Gioacchino Tedeschi, Gavin Giovannoni, Simona Bonavita
e-Health (or digital healthcare) is becoming increasingly relevant in multiple sclerosis (MS) clinical management. We aim to review and discuss current status and future perspective of e-health in people with multiple sclerosis (pwMS). The first part of this review describes how information on MS can be conveyed through the Web and digital media. The second part illustrates recent advances in digital technology that can improve clinical management and in motor and cognitive rehabilitation of pwMS. Finally, this review advocates future development of the "digital case manager" as a new figure to coordinate clinical management and care of pwMS...
September 19, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30230957/liver-injury-with-drugs-used-for-multiple-sclerosis-a-contemporary-analysis-of-the-fda-adverse-event-reporting-system
#4
Ippazio Cosimo Antonazzo, Elisabetta Poluzzi, Emanuele Forcesi, Trond Riise, Kjetil Bjornevik, Elisa Baldin, Luigi Muratori, Fabrizio De Ponti, Emanuel Raschi
BACKGROUND: Drug-induced liver injury (DILI) has been observed in patients with multiple sclerosis (MS), raising concerns on the liver safety of MS drugs. OBJECTIVE: To describe DILI events with MS drugs by analyzing the FDA Adverse Event Reporting System. METHODS: DILI reports were extracted and classified in overall liver injury (OLI), including asymptomatic elevation of liver enzymes, and severe liver injury (SLI). We performed disproportionality analysis by calculating adjusted reporting odds ratios (RORs) with 95% confidence interval (CI) and case-by-case evaluation for concomitant drugs with hepatotoxic potential...
September 19, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30230952/symptomatology-and-symptomatic-treatment-in-multiple-sclerosis-results-from-a-nationwide-ms-registry
#5
Paulus Stefan Rommer, Kerstin Eichstädt, David Ellenberger, Peter Flachenecker, Tim Friede, Judith Haas, Christoph Kleinschnitz, Dieter Pöhlau, Otto Rienhoff, Alexander Stahmann, Uwe Klaus Zettl
BACKGROUND: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease. Over time, symptoms accumulate leading to increased disability of patients. OBJECTIVE: The objective of this article is to analyze the prevalence of symptoms and symptomatic treatment patterns in a nationwide MS registry. METHODS: Data sets from 35,755 patients were analyzed. RESULTS: More than two-thirds of patients were women with a mean age of 46...
September 19, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30230400/glutamate-sensitive-imaging-and-evaluation-of-cognitive-impairment-in-multiple-sclerosis
#6
Kristin P O'Grady, Adrienne N Dula, Bailey D Lyttle, Lindsey M Thompson, Benjamin N Conrad, Bailey A Box, Lydia J McKeithan, Siddharama Pawate, Francesca Bagnato, Bennett A Landman, Paul Newhouse, Seth A Smith
BACKGROUND: Cognitive impairment (CI) profoundly impacts quality of life for patients with multiple sclerosis (MS). Dysfunctional regulation of glutamate in gray matter (GM) has been implicated in the pathogenesis of MS by post-mortem pathological studies and in CI by in vivo magnetic resonance spectroscopy, yet GM pathology is subtle and difficult to detect using conventional T1 - and T2 -weighted magnetic resonance imaging (MRI). There is a need for high-resolution, clinically accessible imaging techniques that probe molecular changes in GM...
September 19, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30226108/a-tale-of-two-demyelinating-diseases-and-zika-virus
#7
Laura A Benjamin
No abstract text is available yet for this article.
September 18, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30179073/imaging-of-meningeal-inflammation-should-become-part-of-the-routine-mri-protocol-no
#8
Mike P Wattjes, Joep Killestein
No abstract text is available yet for this article.
September 4, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30179069/imaging-of-meningeal-inflammation-should-become-part-of-the-routine-mri-protocol-commentary
#9
Àlex Rovira
No abstract text is available yet for this article.
September 4, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30179064/imaging-of-meningeal-inflammation-should-become-part-of-the-routine-mri-protocol-yes
#10
Martina Absinta, Daniel S Reich
No abstract text is available yet for this article.
September 4, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30168779/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
August 31, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30168749/gms-classifier1-does-not-predict-disability-progression-in-multiple-sclerosis
#12
Johannis A van Rossum, Joep Killestein, Luisa M Villar, Peter N Riskind, Mark S Freedman, Charlotte Teunissen
No abstract text is available yet for this article.
August 31, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30168739/tasks-of-activities-of-daily-living-adl-are-more-valuable-than-the-classical-neurological-examination-to-assess-upper-extremity-function-and-mobility-in-multiple-sclerosis
#13
Caspar Ep van Munster, Marcus D'Souza, Saskia Steinheimer, Christian P Kamm, Jessica Burggraaff, Manuela Diederich, Kristina Kravalis, Jonas Dorn, Lorcan Walsh, Frank Dahlke, Ludwig Kappos, Bernard Mj Uitdehaag
BACKGROUND: Accurate clinical assessment in multiple sclerosis (MS) is challenging. The Assess MS system is being developed to automatically quantify motor dysfunction in MS, including upper extremity function (UEF) and mobility. OBJECTIVE: To determine to what extent combinations of standardized movements included in the Assess MS system explain accepted measures of UEF and mobility. METHODS: MS patients were recruited at four European MS centres...
August 31, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30160208/pediatric-onset-multiple-sclerosis-is-associated-with-reduced-parental-health-related-quality-of-life-and-family-functioning
#14
Julia O'Mahony, Ruth Ann Marrie, Audrey Laporte, Amit Bar-Or, E Ann Yeh, Adalsteinn Brown, Marie-Emmanuelle Dilenge, Brenda Banwell
BACKGROUND: Diagnosis of multiple sclerosis (MS) during childhood has the potential to impact the affected child's self-perception and the health-related quality of life (HRQoL) of the family. OBJECTIVE: To evaluate the impact of chronic disease, in children ascertained as having MS and their families, when compared to those with monophasic acquired demyelinating syndrome (monoADS). METHODS: In a national prospective cohort study of pediatric acquired demyelinating syndromes (ADS), the HRQoL of children and their families was captured using the Pediatric Quality of Life Inventory (PedsQL™ ) Modules...
August 30, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30141729/toward-a-low-cost-in-home-telemedicine-enabled-assessment-of-disability-in-multiple-sclerosis
#15
Riley Bove, Carolyn Bevan, Elizabeth Crabtree, Chao Zhao, Refujia Gomez, Priya Garcha, John Morrissey, Jason Dierkhising, Ari J Green, Stephen L Hauser, Bruce Ac Cree, Mitchell T Wallin, Jeffrey M Gelfand
BACKGROUND: Remote assessment of neurological disability in people with multiple sclerosis (MS) could improve access to clinical care and efficiency of clinical research. OBJECTIVE: To develop and validate a telemedicine-based MS disability examination that does not require an in-home examiner. METHODS: Adults with MS were recruited after a standardized in-person Expanded Disability Status Scale (EDSS) evaluation, and within 1 week underwent a blinded televideo-enabled EDSS examination with a different clinician...
August 24, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30141723/over-three-decades-study-populations-in-progressive-multiple-sclerosis-have-become-older-and-more-disabled-but-have-lower-on-trial-progression-rates-a-systematic-review-and-meta-analysis-of-43-randomised-placebo-controlled-trials
#16
Richard S Nicholas, Erika Han, Joel Raffel, Jeremy Chataway, Tim Friede
BACKGROUND: Progression is the major driver of disability and cost in multiple sclerosis (MS). However, the search for treatments in progressive multiple sclerosis (PMS) has not mirrored the success in relapsing MS. OBJECTIVES: To assess changes in PMS trials over time. METHODS: PubMed, MEDLINE and Embase were searched to identify randomised, double-blind, placebo-controlled trials in PMS. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used, study quality was assessed and trends were examined by regression...
August 24, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30136895/astrocytes-play-a-crucial-role-in-the-formation-and-evolution-of-ms-lesions-yes
#17
David Pitt, Gerald Ponath
No abstract text is available yet for this article.
August 23, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30136890/astrocytes-play-a-crucial-role-in-the-formation-and-evolution-of-ms-lesions-commentary
#18
Francisco J Quintana
No abstract text is available yet for this article.
August 23, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30136889/astrocytes-play-a-crucial-role-in-the-formation-and-evolution-of-ms-lesions-no
#19
Nicole Kerlero de Rosbo
No abstract text is available yet for this article.
August 23, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30132396/a-call-for-more-research-and-global-collaboration-in-south-east-asia-to-address-challenges-of-dmt-access-and-ms-management-in-the-region
#20
Lavanya Vijayasingham, Shanthi Viswanathan
No abstract text is available yet for this article.
August 22, 2018: Multiple Sclerosis: Clinical and Laboratory Research
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