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Multiple Sclerosis: Clinical and Laboratory Research

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https://www.readbyqxmd.com/read/30019626/t-cell-activation-marker-scd27-is-associated-with-clinically-definite-multiple-sclerosis-in-childhood-acquired-demyelinating-syndromes
#1
Yu Yi M Wong, Roos M van der Vuurst de Vries, E Daniëlle van Pelt, Immy A Ketelslegers, Marie-José Melief, Annet F Wierenga, Coriene E Catsman-Berrevoets, Rinze F Neuteboom, Rogier Q Hintzen
BACKGROUND: Cerebrospinal fluid (CSF) levels of T-cell activation marker soluble CD27 (sCD27) are associated with subsequent disease activity after a first attack of suspected MS in adults. The predictive value for disease course in children with acquired demyelinating syndromes (ADS) is unknown. OBJECTIVES: To assess the predictive value of sCD27 levels for clinically definite multiple sclerosis (CDMS) diagnosis in childhood ADS. METHODS: Children <18 years with a first demyelinating event were prospectively included and followed...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30010482/a-decline-in-cognitive-function-should-lead-to-a-change-in-disease-modifying-therapy-commentary
#2
Maria Pia Amato
No abstract text is available yet for this article.
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30010476/a-decline-in-cognitive-function-should-lead-to-a-change-in-disease-modifying-therapy-yes
#3
Bianca Weinstock-Guttman, Svetlana Eckert, Ralph Hb Benedict
No abstract text is available yet for this article.
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30010469/a-decline-in-cognitive-function-should-lead-to-a-change-in-disease-modifying-therapy-no
#4
Emilio Portaccio
No abstract text is available yet for this article.
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/30004291/altered-nuclei-specific-thalamic-functional-connectivity-patterns-in-multiple-sclerosis-and-their-associations-with-fatigue-and-cognition
#5
Fuchun Lin, Robert Zivadinov, Jesper Hagemeier, Bianca Weinstock-Guttman, Caila Vaughn, Sirin Gandhi, Dejan Jakimovski, Hanneke E Hulst, Ralph Hb Benedict, Niels Bergsland, Tom Fuchs, Michael G Dwyer
BACKGROUND: The thalamus, affected early in multiple sclerosis (MS), is a heterogeneous composition of functionally distinct nuclei and is associated with fatigue, cognition, and other outcomes. However, most previous functional imaging studies considered the thalamus only as a whole. OBJECTIVE: To investigate MS-related abnormalities in nuclei-specific thalamic functional connectivity (FC) and their associations with fatigue and cognitive outcomes. METHODS: Resting-state functional magnetic resonance imaging (fMRI) was analyzed in 64 MS patients and 26 healthy controls (HC)...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29992856/histopathological-correlation-of-diffusion-basis-spectrum-imaging-metrics-of-a-biopsy-proven-inflammatory-demyelinating-brain-lesion-a-brief-report
#6
Afsaneh Shirani, Peng Sun, Robert E Schmidt, Kathryn Trinkaus, Robert T Naismith, Sheng-Kwei Song, Anne H Cross
Diffusion basis spectrum imaging (DBSI) models diffusion-weighted magnetic resonance imaging (MRI) signals as a combination of discrete anisotropic diffusion tensors and a spectrum of isotropic diffusion tensors. Here, we report the histopathological correlates of DBSI in the biopsied brain tissue of a patient with an inflammatory demyelinating lesion typical of multiple sclerosis (MS). Increased radial diffusivity (marker of demyelination), decreased fiber fraction (apparent axonal density), elevated nonrestricted isotropic fraction (marker of vasogenic edema), but unchanged axial diffusivity (marker of integrity of residual axons) seen in the lesion appeared consistent with histopathological findings of inflammatory demyelination with relative axonal sparing...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29992853/corrigendum
#7
(no author information available yet)
Abstracts: 23rd Annual RIMS Conference 2018. Mult Scler 2018; 24: 832-837. DOI: 10.1177/1352458518771862 . In the above conference abstracts, published in the May 2018 issue of Multiple Sclerosis Journal, the co-authors were missed from submission ID 103. The correct list of authors appears below.
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29985095/impact-of-mindfulness-based-stress-reduction-for-people-with-multiple-sclerosis-at-8-weeks-and-12-months-a-randomized-clinical-trial
#8
Angela Senders, Douglas Hanes, Dennis Bourdette, Kimberly Carson, Lynn M Marshall, Lynne Shinto
BACKGROUND: Mindfulness training is often used as a therapeutic intervention to manage stress and enhance emotional well-being, yet trials for multiple sclerosis (MS) are limited and few have used an active control. OBJECTIVE: Assess the feasibility of mindfulness-based stress reduction (MBSR) for people with MS and evaluate the efficacy of MBSR compared to an education control. METHODS: We conducted a single-blind, randomized trial of MBSR versus education control among 62 adults with MS...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29985092/cerebrospinal-fluid-mitochondrial-dna-levels-in-patients-with-multiple-sclerosis
#9
Nicolas Fissolo, Laura Cervera-Carles, Luisa María Villar Guimerans, Alberto Lleó, Jordi Clarimón, Jelena Drulovic, Irena Dujmovic, Margarete Voortman, Michael Khalil, Elia Gil, Laura Navarro, Jose Carlos Álvarez-Cermeño, Xavier Montalban, Manuel Comabella
The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29985084/drug-associated-progressive-multifocal-leukoencephalopathy-in-multiple-sclerosis-patients
#10
Yasuo Oshima, Tetsuya Tanimoto, Koichiro Yuji, Arinobu Tojo
OBJECTIVE: To investigate characteristics of multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients associated with drugs other than natalizumab since our experience in other disease-modifying drugs (DMD) is still limited. METHODS: This is a descriptive observational study within the FAERS database, registered between July 2015 and June 2017. RESULTS: The primary cohort for the analysis consisted of 100,921 MS patients (mean (standard deviation (sd)) age, 48...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29985083/primary-optic-neuropathy-in-beh%C3%A3-et-s-syndrome
#11
Qinglin Yang, Lin Sun, Qian Wang, Jiawei Wang, Chao Meng, Qinglin Chang, Xuehui Shi, Shilei Cui, Lei Liu, Chuntao Lai
BACKGROUND: Primary optic neuropathy in Behçet's syndrome (PONBS) is limited to a few case reports. OBJECTIVE: To investigate the clinical features, magnetic resonance imaging (MRI) changes, and visual prognosis of PONBS. METHODS: Sixty-one patients who presented with first onset of optic neuritis and fulfilled the International Criteria for Behçet's Disease (ICBD) were evaluated. RESULTS: The female-to-male ratio was 1...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29979093/five-years-before-multiple-sclerosis-onset-phenotyping-the-prodrome
#12
José Ma Wijnands, Feng Zhu, Elaine Kingwell, Yinshan Zhao, Okechukwu Ekuma, Xinya Lu, Charity Evans, John D Fisk, Ruth Ann Marrie, Helen Tremlett
BACKGROUND: The multiple sclerosis (MS) prodrome is poorly characterized. OBJECTIVE: To phenotype the MS prodrome via health care encounters. METHODS: Using data from a population-based cohort study linking administrative and clinical data in four Canadian provinces, we compared physician and hospital encounters and prescriptions filled (via International Classification of Diseases chapters, physician specialty or drug classes) for MS subjects in the 5 years before the first demyelinating claim in an administrative cohort or the clinical symptom onset in an MS clinic-derived cohort, to age-, sex- and geographically matched controls...
July 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29932357/lifetime-exposure-to-ultraviolet-radiation-and-the-risk-of-multiple-sclerosis-in-the-us-radiologic-technologists-cohort-study
#13
Lisa G Gallagher, Sindana Ilango, Annette Wundes, Gary A Stobbe, Katherine W Turk, Gary M Franklin, Martha S Linet, D Michal Freedman, Bruce H Alexander, Harvey Checkoway
BACKGROUND: Low exposure to ultraviolet radiation (UVR) from sunlight may be a risk factor for developing multiple sclerosis (MS). Possible pathways may be related to effects on immune system function or vitamin D insufficiency, as UVR plays a role in the production of the active form of vitamin D in the body. OBJECTIVE: This study examined whether lower levels of residential UVR exposure from sunlight were associated with increased MS risk in a cohort of radiologic technologists...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29932341/a-framework-for-measurement-and-harmonization-of-pediatric-multiple-sclerosis-etiologic-research-studies-the-pediatric-ms-tool-kit
#14
Sandra Magalhaes, Brenda Banwell, Amit Bar-Or, Isabel Fortier, Heather E Hanwell, Ming Lim, Georg E Matt, Rinze F Neuteboom, David L O'Riordan, Paul K Schneider, Maura Pugliatti, Bryna Shatenstein, Catherine M Tansey, Evangeline Wassmer, Christina Wolfson
BACKGROUND: While studying the etiology of multiple sclerosis (MS) in children has several methodological advantages over studying etiology in adults, studies are limited by small sample sizes. OBJECTIVE: Using a rigorous methodological process, we developed the Pediatric MS Tool-Kit, a measurement framework that includes a minimal set of core variables to assess etiological risk factors. METHODS: We solicited input from the International Pediatric MS Study Group to select three risk factors: environmental tobacco smoke (ETS) exposure, sun exposure, and vitamin D intake...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29916300/commentary-on-al-hussona-et-al-new-onset-seizures-as-a-sole-clinical-presentation-of-multiple-sclerosis
#15
Declan T Chard
Despite the now significant contribution of magnetic resonance imaging, the accurate and timely diagnosis of multiple sclerosis (MS) is still clinically challenging. Al Hussona et al., with their case series, highlight the complexities of attributing paroxysmal, and in particular cortical, symptoms such as epileptic seizures to inflammatory demyelinating lesions, and establishing a diagnosis of MS based on them. In such circumstances an MS diagnosis is likely to be more tentative than for more typical MS presentations, and treatment choices should be weighed accordingly...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29916293/new-onset-seizures-as-a-sole-clinical-presentation-of-multiple-sclerosis
#16
Mariam Al Hussona, Hugh Kearney, Arie Fisher, John Lynch, Seamus Looby, Norman Delanty
BACKGROUND AND OBJECTIVES: Epileptic seizures frequently occur in people with multiple sclerosis (MS) and are thought to represent a manifestation of cortical pathology. However, at present, seizures are not considered to be a typical clinical presentation of demyelination. METHODS AND RESULTS: In this case series, we identified four people, who presented with seizures as a sole presenting feature, with demyelinating imaging abnormalities that satisfy current diagnostic criteria for a clinically isolated syndrome (CIS) or early MS...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29911471/successful-implementation-of-an-automated-electronic-support-system-for-patient-safety-monitoring-the-alemtuzumab-in-multiple-sclerosis-safety-systems-ams3-study
#17
Stephen W Reddel, Michael H Barnett, Sean Riminton, Tej Dugal, Katherine Buzzard, Chenu Tim Wang, Fiona Fitzgerald, Heidi N Beadnall, Diane Erickson, David Gahan, Daniel Wang, Toby Ackland, Richard Thompson
BACKGROUND: Alemtuzumab is a highly effective treatment for relapsing-remitting multiple sclerosis (MS) but requires ongoing pathology monitoring for autoimmune adverse effects. The Alemtuzumab in MS Safety Systems (AMS3) study evaluated the implementation of an automated pathology-monitoring system. OBJECTIVES: To develop an efficient automated clinical decision support system (CDSS) to electronically prompt and track pathology collection and to provide prescribers and patients with customised alerts of abnormal results for identified risks...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29911469/estimating-ms-related-work-productivity-loss-and-factors-associated-with-work-productivity-loss-in-a-representative-australian-sample-of-people-with-multiple-sclerosis
#18
Jing Chen, Bruce Taylor, Andrew J Palmer, Andrea Kirk-Brown, Pieter van Dijk, Steve Simpson, Leigh Blizzard, Ingrid van der Mei
BACKGROUND: Little is known about the work productivity loss in multiple sclerosis (MS). OBJECTIVES: To quantify the MS-related work productivity loss and to compare factors associated with labour force participation and work productivity loss. METHODS: Participants were from the Australian MS Longitudinal Study. MS-related work productivity loss included absenteeism (time missed from work) and presenteeism (reduced productivity while working)...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29911467/predicting-risk-of-secondary-progression-in-multiple-sclerosis-a-nomogram
#19
Ali Manouchehrinia, Feng Zhu, Daniela Piani-Meier, Markus Lange, Diego G Silva, Robert Carruthers, Anna Glaser, Elaine Kingwell, Helen Tremlett, Jan Hillert
OBJECTIVES: We aimed at designing a nomogram, a prediction tool, to predict the individual's risk of conversion to secondary progressive multiple sclerosis (SPMS) at the time of multiple sclerosis (MS) onset. METHODS: One derivation and three validation cohorts were established. The derivation cohort included 8825 relapsing-onset MS patients in Sweden. A nomogram was built based on a survival model with the best statistical fit and prediction accuracy. The nomogram was validated using data from 3967 patients in the British Columbia cohort, 176 patients in the ACROSS and 2355 patients in FREEDOMS/FREEDOMS II extension studies...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29909771/focal-and-diffuse-cervical-spinal-cord-damage-in-patients-with-early-relapsing-remitting-ms-a-multicentre-magnetisation-transfer-ratio-study
#20
Benoît Combès, Anne Kerbrat, Jean Christophe Ferré, Virginie Callot, Josefina Maranzano, Atef Badji, Emmanuelle Le Page, Pierre Labauge, Xavier Ayrignac, Clarisse Carra Dallière, Nicolas Menjot de Champfleur, Jean Pelletier, Adil Maarouf, Jérôme de Seze, Nicolas Collongues, David Brassat, Françoise Durand-Dubief, Christian Barillot, Elise Bannier, Gilles Edan
BACKGROUND: Studies including patients with well-established multiple sclerosis (MS) have shown a significant and disability-related reduction in the cervical spinal cord (SC) magnetisation transfer ratio (MTR). OBJECTIVES: The objectives are to (1) assess whether MTR reduction is already measurable in the SC of patients with early relapsing-remitting multiple sclerosis (RRMS) and (2) describe its spatial distribution. METHODS: We included 60 patients with RRMS <12  months and 34 age-matched controls at five centres...
June 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
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