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Journal of Pediatric Endocrinology & Metabolism: JPEM

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https://www.readbyqxmd.com/read/30407912/early-adiposity-rebound-in-patients-with-prader-willi-syndrome
#1
Yuji Oto, Nobuyuki Murakami, Keiko Matsubara, Hiroyuki Ogata, Hiroshi Ihara, Tomoyo Matsubara, Toshiro Nagai
Background Prader-Willi syndrome (PWS) is associated with marked obesity that can lead to severe complications such as diabetes mellitus. Early adiposity rebound (AR) is associated with future obesity and an increased risk of diabetes mellitus and metabolic syndrome. Previous reports have shown that the onset of AR occurred earlier in diseases that cause obesity. However, there have been no studies focusing on the timing of AR in PWS, or on the effect of growth hormone (GH) treatment on AR. The aim of this study was to explore AR in PWS patients and to analyze the effect of GH treatment on AR...
November 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30367808/a-case-of-an-infant-with-extremely-low-birth-weight-and-hypothyroidism-associated-with-massive-cutaneous-infantile-hemangioma
#2
Aiko Igarashi, Ikue Hata, Miori Yuasa, Takashi Okuno, Yusei Ohshima
Background Although hepatic infantile hemangioma (IH) may correlate with consumptive hypothyroidism consequent to the overexpression of thyroid hormone inactivating enzyme by hemangioma cells, hypothyroidism has been rarely recognized in infants with cutaneous hemangioma. Case presentation A male infant born at 28 weeks of gestational age with an extremely low birth weight (775 g) developed a massive cutaneous hemangioma on his neck and severe abdominal distension. Imaging examinations detected a small mass lesion in the brain but no hepatic hemangioma...
October 26, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30352041/multi-disciplinary-evaluation-of-a-5-month-old-with-hypertrophic-cardiomyopathy-related-to-a-functional-adrenocortical-tumor
#3
Laura M Nally, Erin Conner, Sharon Paige, Kelly L Mooney, Urs Naber, Rebecca Richards, Gail Wright
Background Hypertrophic cardiomyopathy (HCM) in childhood is a rare diagnosis, and associations with adrenocortical tumors (ACTs) have been rarely reported in the pediatric literature. Case Presentation We present a case of a 5-month-old who presented with HCM and during the evaluation for hypertension was found to have elevated glucocorticoids, mineralocorticoids, androgens and urine metanephrines. During preoperative evaluation, he developed shock followed by cardiogenic collapse requiring extracorporeal membrane oxygenation (ECMO); however, he did not survive...
October 23, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30183666/evaluation-of-anthropometric-parameters-of-central-obesity-in-pakistani-children-aged-5-12-years-using-receiver-operating-characteristic-roc-analysis
#4
Muhammad Asif, Muhammad Aslam, Saima Altaf
No abstract text is available yet for this article.
September 5, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30179852/omentin-1-and-nampt-serum-concentrations-are-higher-and-ck-18-levels-are-lower-in-children-and-adolescents-with-type-1-diabetes-when-compared-to-healthy-age-sex-and-bmi-matched-controls
#5
Esra Nurten, Mandy Vogel, Thomas Michael Kapellen, Sandy Richter, Antje Garten, Melanie Penke, Susanne Schuster, Antje Körner, Wieland Kiess, Jürgen Kratzsch
No abstract text is available yet for this article.
September 4, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30173205/growth-of-patients-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-in-infancy-glucocorticoid-requirement-and-the-role-of-mineralocorticoid-therapy
#6
Jack Sellick, Sarah Aldridge, Matthew Thomas, Tim Cheetham
No abstract text is available yet for this article.
September 3, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30130252/successful-treatment-of-life-threatening-severe-metabolic-acidosis-by-continuous-veno-venous-hemodialysis-in-a-child-with-diabetic-ketoacidosis
#7
Osman Yesilbas, Ela Cem, Emine Ayca Cimbek
No abstract text is available yet for this article.
August 21, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30130251/etiology-of-short-stature-in-indian-children-and-an-assessment-of-the-growth-hormone-insulin-like-growth-factor-axis-in-children-with-idiopathic-short-stature
#8
Anil Kumar, Ankita Pal, Mani Kalaivani, Nandita Gupta, Vandana Jain
No abstract text is available yet for this article.
August 21, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30367807/cardiometabolic-risk-factors-in-preschool-children-with-abdominal-obesity-from-medell%C3%A3-n-colombia
#9
Catalina Marín-Echeverri, Juan C Aristizábal, Natalia Gallego-Lopera, Hugo A Santa-Ramírez, Marcela Hoyos-Gómez, Adriana Marcela Ruiz-Pineda, Andrés A Arias, Jacqueline Barona-Acevedo
Background Abdominal obesity (AO) is linked to inflammation and insulin resistance (IR). However, there is limited information on whether preschoolers with AO present these risk factors. We evaluated the association between AO and cardiovascular risk factors in preschoolers. Methods We enrolled 232 children (2-5 years), of whom 50% had AO. Serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), high-density lipoprotein-cholesterol (HDL-c), triglycerides (TG), apolipoprotein B (Apo-B) and apolipoprotein A-1 (Apo-A1), glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, monocyte chemoattractant protein (MCP-1/CCL2), leptin, adiponectin, vascular cell adhesion molecule (VCAM-1/CD106) and intercellular adhesion molecule (ICAM-1/CD54) were measured...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30367806/the-prevalence-and-volumetry-of-pituitary-cysts-in-children-with-growth-hormone-deficiency-and-idiopathic-short-stature
#10
Nicholas Krasnow, Bradley Pogostin, James Haigney, Brittany Groh, Winston Weiler, Michael Tenner, Marion Kessler, Michael Frey, Richard A Noto
Background Pituitary cysts have been speculated to cause endocrinopathies. We sought to describe the prevalence and volumetry of pituitary cysts in patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS). Methods Six hundred and eighteen children evaluated for growth failure at the Division of Pediatric Endocrinology at New York Medical College between the years 2002 and 2012, who underwent GH stimulation testing and had a brain magnetic resonance imaging (MRI) prior to initiating GH treatment were randomly selected to be a part of this study...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30352040/long-term-follow-up-of-gonadal-dysfunction-in-morbidly-obese-adolescent-boys-after-bariatric-surgery
#11
Vivian L Chin, Kristen M Willliams, Tegan Donnelley, Marisa Censani, Rushika Conroy, Shulamit Lerner, Sharon E Oberfield, Donald J McMahon, Jeffrey Zitsman, Ilene Fennoy
Background Elevated body mass index (BMI) is associated with hypogonadism in men but this is not well described in adolescents. The aim is to evaluate gonadal dysfunction and the effects of weight loss after gastric banding in obese adolescent boys. Methods Thirty-seven of 54 boys (age 16.2±1.2 years, mean BMI 48.2 kg/m2) enrolled at the Center for Adolescent Bariatric Surgery at Columbia University Medical Center had low total testosterone for Tanner 5 <350 ng/dL. Sixteen had long-term hormonal data for analysis at baseline (T0), 1 year (T1) and 2 years (T2) post-surgery...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30352039/carotid-intima-media-thickness-and-associations-with-serum-osteoprotegerin-and-s-rankl-in-children-and-adolescents-with-type-1-diabetes-mellitus-with-increased-risk-for-endothelial-dysfunction
#12
Kyriaki Karavanaki, Emmanouil Tsouvalas, Marina Vakaki, Alexandra Soldatou, Charalambos Tsentidis, George Kaparos, Areti Augoulea, Andreas Alexandrou, Ιrene Lambrinoudaki
Background Although carotid intima media thickness (CIMT) is an established marker of endothelial dysfunction, limited data exist on relative laboratory biomarkers in youngsters with type 1 diabetes mellitus (T1DM). Our aim was to study CIMT and the biomarkers of the osteoprotegerin (OPG)/RANKL system in young T1DM patients and controls, and also in subgroups of patients with increased risk for endothelial dysfunction, such as those with overweight/obesity, poor metabolic control or the presence of microalbuminuria...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30352038/adolescents-with-premenstrual-syndrome-not-only-what-you-eat-but-also-how-you-eat-matters
#13
Kubra Isgin-Atici, Zehra Buyuktuncer, Sinem Akgül, Nuray Kanbur
Background Current literature suggests that diet is involved in either the development of premenstrual syndrome (PMS) or contributes to symptom severity, but to date, there are no studies evaluating eating attitudes of adolescents with PMS. The aim of this study was to evaluate dietary intake and eating attitudes in adolescents with PMS. Methods This study was conducted with 383 adolescents (214 with and 169 without PMS), aged 13-19 years. PMS was diagnosed using the premenstrual syndrome scale (PMSS). The Food Frequency Questionnaire (FFQ) and 24-h dietary recall were used to assess dietary intake...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30335613/fgfr3-related-hypochondroplasia-longitudinal-growth-in-57-children-with-the-p-asn540lys-mutation
#14
María Alejandra Arenas, Mariana Del Pino, Virginia Fano
Background Children with hypochondroplasia (HCH), who have FGFR3 mutations c.1620C>A or c.1620C>G (p.Asn540Lys) appear to have a more severe phenotype than those with HCH without these mutations. We describe the change in height, leg length and body proportions in a retrospective cohort of children with HCH related-p.Asn540Lys mutation and we compared them with Argentine population. Methods Anthropometric measurements were initially taken and followed up by the same observer, with standardized techniques...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30335612/the-association-of-hs-crp-and-fibrinogen-with-anthropometric-and-lipid-parameters-in-non-obese-adolescent-girls-with-polycystic-ovary-syndrome
#15
Ilijana Mažibrada, Tatjana Djukić, Svetlana Perović, Marija Plješa-Ercegovac, Ljiljana Plavšić, Dragana Bojanin, Jelica Bjekić-Macut, Petar D Simić, Tatjana Simić, Ana Savić-Radojević, George Mastorakos, Djuro Macut
Background The aim of the study was to evaluate high-sensitivity C-reactive protein (hs-CRP) and fibrinogen in non-obese normoinsulinemic adolescent girls with polycystic ovary syndrome (PCOS) and their relationship with anthropometric and lipid parameters. Methods The study comprised a total of 26 adolescent girls newly diagnosed with PCOS and 12 healthy controls with regular ovulatory menstrual cycles. The concentration of hs-CRP, fibrinogen, anthropometric measurements, and biochemical and hormonal testing were assessed...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30332396/shox-gene-deletion-screening-by-fish-in-children-with-short-stature-and-madelung-deformity-and-their-characteristics
#16
Erdal Kurnaz, Şenay Savaş-Erdeve, Semra Çetinkaya, Zehra Aycan
Background The short stature homeobox-containing (SHOX) gene strongly affects height. Therefore, a better understanding of SHOX haploinsufficiency could be advantageous to early diagnosis and treatment. We investigated the rate of SHOX haploinsufficiency in patients of short stature and documented their anthropometric measurements. Methods Between 2010 and 2017, we evaluated 86 patients (70 females, 16 males; age 4.3-18 years) with clinical diagnoses of short stature and Madelung deformity (MD). Clinical abnormalities are presented for patients with MD with and without SHOX haploinsufficiency as determined by fluorescence in situ hybridisation (FISH)...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30332395/basal-characteristics-and-first-year-responses-to-human-growth-hormone-gh-vary-according-to-diagnostic-criteria-in-children-with-non-acquired-gh-deficiency-naghd-observations-from-a-single-center-over-a-period-of-five-decades
#17
Michael B Ranke, Roland Schweizer, Gerhard Binder
Background Children with non-acquired (na) growth hormone deficiency (GHD) diagnosed over decades in one center may provide perspective insight. Methods naGHD is divided into idiopathic GHD (IGHD), GHD of known cause (cGHD) and GHD neurosecretory dysfunction (NSD); time periods: <1988 (I); 1988-1997 (II); 1998-2007 (III); 2008-2015 (IV). Descriptive analyses were performed at diagnosis and during first year GH treatment. Results Patients (periods, N): I, 87; II, 141; III, 356; IV, 51. In cGHD (all), age, maximum GH, insulin-like growth factor-I (IGF-I), and insulin-like growth factor-binding protein-3 (IGFBP-3) (5...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30325735/high-urate-concentration-is-associated-with-elevated-blood-pressure-in-schoolchildren
#18
Luiza Naujorks Reis, Cézane Priscila Reuter, Jane Dagmar Pollo Renner, Leandro Tibiriçá Burgos, Silvia Isabel Rech Franke, Miria Suzana Burgos
Background Studies in adults have shown a relationship between high blood pressure and hyperuricemia, but few studies have investigated this association in children and adolescents. The aim of the present study was to associate urate concentration with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in schoolchildren. Methods This cross-sectional study used a sample of 2335 schoolchildren in basic education between 7 and 17 years old. Blood pressure was classified by percentile according to Brazilian parameters for sex and age, reclassified into two categories: normal and borderline/hypertension...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30325734/thyroid-dysfunction-in-children-with-leukemia-over-the-first-year-after-hematopoietic-stem-cell-transplantation
#19
Yoon-Ji Lee, Hyun Young Lee, Moon Bae Ahn, Seong-Koo Kim, Won Kyoung Cho, Jae-Wook Lee, Nack-Gyun Chung, Bin Cho, Byung-Kyu Suh
Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0.8-21.8) years old] were reviewed retrospectively. Results In children with leukemia, T3 decreased at 1 month (p<0.001) and recovered 9 months to the levels before HSCT. TSH decreased at 1 month (p<0.001), recovered at 3 months and increased at 12 months (p<0...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30325733/leptin-and-adiposity-as-mediators-on-the-association-between-early-puberty-and-several-biomarkers-in-european-adolescents-the-helena-study
#20
Tara Rendo-Urteaga, Augusto César Ferreira de Moraes, Francisco Leonardo Torres-Leal, Yannis Manios, Frederic Gottand, Michael Sjöström, Anthony Kafatos, Kurt Widhalm, Stefaan De Henauw, Dénes Molnár, Ascensión Marcos, Marcela González-Gross, Marika Ferrari, Heráclito B Carvalho, Luis A Moreno
Background Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods A sample of 511 adolescents with EP (12.5-17.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed...
November 27, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
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