Pondpan Suwanthada, Siriporn Kongsoi, Nami Miura, Lawrence P Belotindos, Chayada Piantham, Jirachaya Toyting, Mwangala L Akapelwa, Ruttana Pachanon, Kentaro Koide, Hyun Kim, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki
Although many drug-resistant nontyphoidal Salmonella (NTS) infections are reported globally, their treatment is challenging owing to the ineffectiveness of the currently available antimicrobial drugs against resistant bacteria. It is therefore essential to discover novel antimicrobial drugs for the management of these infections. In this study, we report high inhibitory activities of the novel fluoroquinolones (FQs; WQ-3810 and WQ-3334) with substitutions at positions R-1 by 6-amino-3,5-difluoropyridine-2-yl and R-8 by methyl group or bromine, respectively, against wild-type and mutant DNA gyrases of Salmonella Typhimurium...
October 4, 2023: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease