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Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease

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https://www.readbyqxmd.com/read/30212274/diverse-plasmids-harboring-bla-ctx-m-15-in-klebsiella-pneumoniae-st11-isolates-from-several-asian-countries
#1
So Yeon Kim, Kwan Soo Ko
To reveal whether an increase of CTX-M-15-producing Klebsiella pneumoniae ST11 isolates is due to clonal dissemination across the countries, plasmids (pHK02-026, pM16-13, pIN03-01, and pTH02-34) were extracted from four K. pneumoniae isolates collected in Hong Kong, Malaysia, Thailand, and Indonesia, respectively. Complete sequencing of blaCTX-M-15 -carrying plasmids was performed. In addition to the four plasmids, a previously sequenced plasmid (pKP12226) of a K. pneumoniae ST11 isolate from Korea was included in the analysis...
September 13, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30179517/characterization-of-highly-prevalent-plasmids-coharboring-mcr-1-oqxab-and-bla-ctx-m-and-plasmids-harboring-oqxab-and-bla-ctx-m-in-escherichia-coli-isolates-from-food-producing-animals-in-china
#2
Bao-Tao Liu, Feng-Jing Song, Ming Zou
The emergence and spread of multidrug resistance (MDR) plasmids carrying the colistin resistance gene mcr-1 has become a major public health concern. However, there is a paucity of data regarding the prevalence of mcr-1 plasmids concomitantly carrying blaCTX-M and oqxAB, an efflux pump that confers resistance to multiple agents. In this study, we determined the prevalence and characteristics of plasmids coharboring mcr-1, oqxAB, and blaCTX-M as well as those harboring oqxAB and blaCTX-M in Escherichia coli from food-producing animals...
September 4, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30153086/detection-of-the-novel-optra-gene-among-linezolid-resistant-enterococci-in-barcelona-spain
#3
Jordi Càmara, Mariana Camoez, Fe Tubau, Miquel Pujol, Josefina Ayats, Carmen Ardanuy, M Ángeles Domínguez
The purpose of this study was to describe the presence of the novel optrA gene among clinical isolates of enterococci in a Spanish teaching hospital (May 2016-April 2017). optrA and cfr genes were screened by PCR in all isolates showing linezolid minimal inhibitory concentration (MIC) ≥4 mg/L. The genetic relatedness of the isolates, the presence of resistance and virulence genes, and the genetic environment of optrA were assessed by whole-genome sequencing (WGS). Six of 1,640 enterococci had linezolid MIC ≥4 mg/L...
August 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30153069/whole-genome-analysis-of-a-human-enterobacter-mori-isolate-carrying-a-bla-imi-2-carbapenemase-in-austria
#4
Rainer Hartl, Heidrun Kerschner, Rainer Gattringer, Sarah Lepuschitz, Franz Allerberger, Sieglinde Sorschag, Werner Ruppitsch, Petra Apfalter
Enterobacterales belonging to the genus Enterobacter are well-known human pathogens and blaIMI carrying strains have been described in several countries. From Austria, we report on the first human Enterobacter mori isolate, typically a plant pathogen, which showed an undescribed multilocus sequence type and carried a blaIMI-2 carbapenemase.
August 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30142035/relationship-between-biofilm-formation-and-antimicrobial-resistance-in-gram-negative-bacteria
#5
Virginio Cepas, Yuly López, Estela Muñoz, Dora Rolo, Carmen Ardanuy, Sara Martí, Mariona Xercavins, Juan Pablo Horcajada, Jordi Bosch, Sara M Soto
Gram-negative microorganisms are a significant cause of infection in both community and nosocomial settings. The increase, emergence, and spread of antimicrobial resistance among bacteria are the most important health problems worldwide. One of the mechanisms of resistance used by bacteria is biofilm formation, which is also a mechanism of virulence. This study analyzed the possible relationship between antimicrobial resistance and biofilm formation among isolates of three Gram-negative bacteria species. Several relationships were found between the ability to form biofilm and antimicrobial resistance, being different for each species...
August 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30142027/prevalence-of-extended-spectrum-beta-lactamase-producing-gram-negative-bacilli-and-emergence-of-mcr-1-colistin-resistance-gene-in-lebanese-swine-farms
#6
Iman Dandachi, Elie Fayad, Bassel El-Bazzal, Ziad Daoud, Jean-Marc Rolain
Livestock are considered reservoirs of multidrug-resistant organisms that can be transferred to humans through direct/indirect routes. Once transmitted, these organisms can be responsible for infections with therapeutic challenges. The aim of this study was to determine the prevalence of extended-spectrum cephalosporin and colistin-resistant Gram-negative bacilli in Lebanese swine farms. In May 2017, 114 fecal samples were collected from swine farms in south Lebanon. Separate media supplemented with cefotaxime, ertapenem, and colistin were used for the screening of resistant organisms...
August 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30133334/antimicrobial-resistance-and-molecular-characterization-of-extended-spectrum-%C3%AE-lactamases-of-escherichia-coli-and-klebsiella-spp-isolates-from-urinary-tract-infections-in-southern-brazil
#7
Juliano Lacava Pereira, Lisiane Martins Volcão, Gabriel Baracy Klafke, Roseli Stone Vieira, Carla Vitola Gonçalves, Ivy Bastos Ramis, Pedro Eduardo Almeida da Silva, Andrea von Groll
The objective of this study was to evaluate the frequency of different extended-spectrum β-lactamases (ESBL) as well as to associate these ESBL with antimicrobial (ATM) resistance in Escherichia coli and Klebsiella spp. isolates from outpatients and inpatients with urinary tract infections. The study included 435 consecutive nonduplicate clinical isolates, including 362 E. coli isolates, 62 Klebsiella pneumoniae isolates, and 11 K. oxytoca isolates. Isolates were obtained from patients who were treated in a University Hospital between August 2012 and July 2013...
August 22, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30129868/spread-of-carbapenem-and-colistin-resistant-klebsiella-pneumoniae-st512-clinical-isolates-in-israel-a-cause-for-vigilance
#8
Rym Lalaoui, Sofiane Bakour, Kashat Livnat, Marc Victor Assous, Seydina M Diene, Jean-Marc Rolain
OBJECTIVES: Genomic and phenotypic characterization of resistance mechanisms to carbapenems and colistin in Klebsiella pneumoniae strains isolated from the Shaare Zedek Medical Center (Jerusalem, Israel). RESULTS: The 15 K. pneumoniae isolates studied present a high level of resistance to the antibiotics tested. Microbiological tests revealed production of carbapenemase enzymes by all isolates. ABI SOLiD sequencing of K. pneumoniae genomes generated between 5,033,665 and 8,876,861 million reads per genome...
August 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30129819/characteristics-of-antibiotic-resistance-of-helicobacter-pylori-among-adult-arab-and-jewish-populations-in-northern-israel
#9
Matan Yeganeh, Maya Paritsky, Avi On, Maya Azrad, Halim Roshrosh, Rawia Moalem, Avi Peretz
AIMS: Following reports from various doctors regarding increased treatment failure in Helicobacter pylori infection among the Arab population, we decided to make a prospective comparison between the resistance rates of H. pylori in the Arab and Jewish populations in northern Israel. RESULTS: Among the Arab population, higher resistance rates were found for clarithromycin and levofloxacin (LEV), as well as a higher rate of multidrug resistance. Rifampin and LEV were found to have higher resistance rates in the village, whereas LEV had a higher resistance rate among women...
August 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30113251/molecular-epidemiology-of-plasmid-mediated-fosfomycin-resistance-gene-determinants-in-klebsiella-pneumoniae-carbapenemase-producing-klebsiella-pneumoniae-isolates-in-china
#10
Jinyun Chen, Dairong Wang, Yueping Ding, Lei Zhang, Xi Li
The Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become a serious problem because the species is wide ranging and there are few treatment options. Fosfomycin has attracted renewed interest in combination therapy for infections caused by KPC-producing K. pneumoniae isolates. Because of the increasing use of fosfomycin, resistant isolates have been continually reported in carbapenem-resistant K. pneumoniae (CRKP). At present, multiple mechanisms can result in fosfomycin resistance. However, there is limited knowledge with respect to plasmid-mediated fosfomycin resistance gene (fosA3) determinants in KPC-producing K...
August 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30113248/multiple-drug-resistance-and-virulence-profiling-of-salmonella-enterica-serovars-typhimurium-and-enteritidis-from-poultry-farms-of-faisalabad-pakistan
#11
Muhammad Wajid, Asad Bashir Awan, Muhammad Kashif Saleemi, Jörg Weinreich, Peter Schierack, Yasra Sarwar, Aamir Ali
The zoonotic serovars of Salmonella enterica particularly Typhimurium and Enteritidis pose a continuous global threat to poultry industry and public health. We report the prevalence of Salmonella Typhimurium and Salmonella Enteritidis serovars in local poultry, phenotypic antimicrobial resistance profiling, and molecular detection of antimicrobial resistance and virulence genes. A total of 340 clinical samples were collected and 239 carried Salmonella, which were identified by genus-specific PCR (invA gene) and by matrix-assisted laser desorption/ionization time-of-flight...
August 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30109975/in-vitro-bactericidal-activity-of-trimethoprim-sulfamethoxazole-colistin-combination-against-carbapenem-resistant-klebsiella-pneumoniae-clinical-isolates
#12
Jiachun Su, Dan Li, Qinglan Guo, Yan Guo, Yonggui Zheng, Xiaogang Xu
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a formidable health challenge in recent years owing to the shortage of effective antibiotics. Colistin is the last and sometimes the only therapeutic option for CRKP infections. Unfortunately, resistance to colistin monotherapy is likely to develop. CRKP in China reportedly exhibit low rates of resistance to trimethoprim-sulfamethoxazole. The aim of this study was to evaluate the in vitro efficacy of trimethoprim-sulfamethoxazole in combination with colistin against four CRKP clinical isolates...
August 15, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30096263/promising-antituberculosis-activity-of-piperine-combined-with-antimicrobials-a-systematic-review
#13
Laíse Adriane Hegeto, Katiany R Caleffi-Ferracioli, JoãoVitor Perez de Souza, Aryadne Larissa de Almeida, Sandra Sayuri Nakamura de Vasconcelos, Isabella Letícia Esteves Barros, Pedro Henrique Canezin, Paula Aline Zanetti Campanerut-Sá, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Jorge Juarez Vieira Teixeira, Rosilene Fressatti Cardoso
Piperine, a bioactive compound from Piper nigrum and Piper longum, has shown promising activity as efflux pump (EP) inhibitor and as adjunct in treatment of tuberculosis (TB). The present systematic review investigated scientific studies of the activity of piperine against mycobacteria, with a focus on its mechanism of action, drug interactions, and antimycobacterial activity. A broad and rigorous literature search of three electronic databases (PubMed, Web of Knowledge, and LILACS) was performed according to the PRISMA statement...
August 10, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30096257/molecular-epidemiological-characterization-of-methicillin-susceptible-and-resistant-staphylococcus-aureus-isolated-from-skin-and-soft-tissue-infections-in-bangladesh
#14
Nazia Haque, Meiji Soe Aung, Shyamal Kumar Paul, Md Shafikul Bari, Salma Ahmed, Santana Rani Sarkar, Sangjukta Roy, Syeda Anjuman Nasreen, Muhammad Chand Mahmud, Muhammad Akram Hossain, Noriko Urushibara, Mitsuyo Kawaguchiya, Ayako Sumi, Nobumichi Kobayashi
Genetic background and molecular characteristics of Staphylococcus aureus collected from patients with skin and soft tissue infections were studied in the North-Central region of Bangladesh from 2015 to 2016. Among 430 clinical isolates, methicillin-resistant S. aureus (MRSA) accounted for 31% having SCCmec type IV (73%) and V (14%), and belonged mostly to coagulase (coa) genotypes IIa, IIIa, IVb, and XIa, while dominant coa type in methicillin-susceptible S. aureus (MSSA) was IIIa, followed by Va, IIa, and VIa...
August 10, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30070968/a-systematic-in-silico-analysis-of-the-legionellaceae-family-for-identification-of-novel-drug-target-candidates
#15
Seyyed Mohsen Sohrabi, Mohsen Mohammadi, Seyyede Nasim Tabatabaiepour, Seyyede Zahra Tabatabaiepour, Hossein Hosseini-Nave, Mohammad Fazel Soltani, Hosniyeh Alizadeh, Morteza Hadizadeh
The family Legionellaceae consists of Gram-negative bacteria that are widely distributed in aquatic environments around the world. This family consists of a single genus, Legionella, that is recognized as an important cause of community-acquired pneumonia and hospital-acquired pneumonia. Legionella consists of intracellular pathogens, thus cellular pharmacokinetic and pharmacodynamic properties of an antibiotic against these bacteria as well as uptake and subcellular distribution into macrophages should be considered for a successful outcome of disease...
August 2, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30070961/molecular-analysis-of-pbp1a-in-streptococcus-pneumoniae-isolated-from-clinical-and-normal-flora-samples-in-tehran-iran-a-multicenter-study
#16
Ali Ahmadi, Sajad Yaghoubi, GholamReza Irajian
The emergence of high-level penicillin resistance in pneumococcal isolates has seriously complicated the treatment of pneumococcal infections in recent years. The purpose of this study was to determine the serotype, antimicrobial susceptibility, molecular typing, and genetic analysis of the penicillin-binding protein 1a (pbp1a) gene in pneumococcal isolates with high-level resistance to penicillin in Tehran, Iran. PCR amplification, sequencing, and data analysis of the pbp1a gene were carried out for isolates with high-level resistance to penicillin...
August 2, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30067166/pme-and-other-esbl-positive-multiresistant-pseudomonas-aeruginosa-isolated-from-hospitalized-patients-in-the-region-of-kurdistan-iraq
#17
Sebastian van Burgh, Delshad M Maghdid, Aryann R Ganjo, Isam Y Mansoor, Dik J Kok, Mohammed H Fatah, Abdulkadir A Alnakshabandi, Dlnya Asad, Anette M Hammerum, Kim Ng, Corné Klaassen, Wil H F Goessens
Nosocomial infections occur worldwide and also in the Kurdistan region. Frequently patients colonized with multiresistant Pseudomonas aeruginosa isolates are encountered in many hospitals. As information is lacking with respect to the mechanisms of resistance responsible for the multiresistant character of the P. aeruginosa isolates and their genetic relationship, isolates were prospectively collected and characterized with respect to their mechanism of resistance. During 2012 and 2013, 81 P. aeruginosa isolates were collected from three teaching hospitals in the city of Erbil, Iraq...
August 1, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30067146/variability-in-the-adaptive-response-of-antibiotic-resistant-salmonella-typhimurium-to-environmental-stresses
#18
Md Jalal Uddin, Gibeom Jeon, Juhee Ahn
This study was designed to evaluate the resistance phenotype and genotype of wild type (WT)-, cefotaxime (CET)-, and ciprofloxacin (CIP)-induced Salmonella Typhimurium ATCC 19585, CIP-resistant Salmonella Typhimurium ATCC 19585, Salmonella Typhimurium CCARM 8009, and Salmonella Typhimurium KCCM 40253 before and after exposure to pH 4.5, 4% NaCl, and heat at 42°C. The susceptibilities of WT Salmonella Typhimurium ATCC 19585 and WT Salmonella Typhimurium KCCM 40253 to all antibiotics tested in this study were decreased after CET and CIP induction with the exception with kanamycin, meropenem, and polymyxin B...
August 1, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30036136/antibacterial-activity-of-dc-159a-against-salmonella-typhimurium
#19
Kentaro Koide, Siriporn Kongsoi, Yuki Ouchi, Tomoyuki Yamaguchi, Chie Nakajima, Yasuhiko Suzuki
Quinolones show excellent antibacterial activity against Salmonella isolates. Recently, however, quinolone resistance has been increasing in bacteria. This study aimed to examine in vitro, and compare the activity of DC-159a against Salmonella enterica serovar Typhimurium with that of ciprofloxacin and nalidixic acid. Inhibitory effects of quinolones were assessed by the drug concentration needed to inhibit the supercoiling activity of recombinant DNA gyrases by 50% (IC50 ). Dilution methods were used to determine the minimum inhibitory concentration (MIC) of quinolones against two different strains, Salmonella Typhimurium and Salmonella Enteritidis...
July 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30036133/complete-sequence-of-a-novel-multidrug-resistant-pseudomonas-putida-strain-carrying-two-copies-of-qnrvc6
#20
Dingqiang Chen, Ling Yang, Brian M Peters, Junyan Liu, Lin Li, Bing Li, Zhenbo Xu, Mark E Shirtliff
This study aimed at identification and characterization of a novel multidrug-resistant Pseudomonas putida strain Guangzhou-Ppu420 carrying two copies of qnrVC6 isolated from a hospital in Guangzhou, China, in 2012. Antimicrobial susceptibility was tested by Vitek2™ Automated Susceptibility System and Etest™ strips, and whole-genome sequencing facilitated analysis of its multidrug resistance. The genome has a length of 6,031,212 bp and an average G + C content of 62.01%. A total of 5,421 open reading frames were identified, including eight 5S rRNA, seven 16S rRNA, and seven 23S rRNA, and 76 tRNA genes...
July 23, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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