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Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease

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https://www.readbyqxmd.com/read/29782237/effect-of-porins-and-bla-kpc-expression-on-activity-of-imipenem-with-relebactam-in-klebsiella-pneumoniae-can-antibiotic-combinations-overcome-resistance
#1
Gregory Balabanian, Michael Rose, Nyla Manning, David Landman, John Quale
Imipenem with relebactam is a novel β-lactam-β-lactamase inhibitor that has activity against most KPC-producing Enterobacteriaceae. Using 10 isolates of KPC-possessing Klebsiella pneumoniae, we assessed the relationship between imipenem-relebactam minimum inhibitory concentrations (MICs) and mechanisms known to contribute to antimicrobial resistance. The effect of adding a second agent was assessed by time-kill experiments. Mutations affecting the genes encoding porins ompK35 and ompK36 and identification of β-lactamases were assessed by PCR...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29782216/carbapenemase-producing-carbapenem-resistant-enterobacteriaceae-from-bangkok-thailand-and-their-detection-by-the-carba-np-and-modified-carbapenem-inactivation-method-tests
#2
Warawut Laolerd, Yukihiro Akeda, Likit Preeyanon, Panan Ratthawongjirakul, Pitak Santanirand
AIM: The purpose of the study was to determine the epidemiology of carbapenemase genes among carbapenem-resistant Enterobacteriaceae and evaluate the Carba NP and modified carbapenem inactivation method (mCIM) tests in their detection. MATERIALS AND METHODS: A total of 287 nonduplicated Enterobacteriaceae isolates, which were at least resistant to one of the carbapenems, were identified and detected for carbapenemase genes by multiplex PCR covering blaKPC , blaNDM , blaVIM , blaIMP , and blaOXA-48-like ...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29782210/colonization-with-enterobacteriaceae-producing-esbls-ampcs-and-oxa-48-in-wild-avian-species-spain-2015-2016
#3
Jesús Oteo, Aida Mencía, Verónica Bautista, Natalia Pastor, Noelia Lara, Fernando González-González, Francisco Javier García-Peña, José Campos
Antibiotic resistance is a global threat of complex and changeable epidemiology. The role of wild birds in the dissemination of antibacterial resistance might be underestimated. We studied the cloacal colonization by cefotaxime-resistant Enterobacteriaceae in 668 wild birds in Spain. Eighty-eight wild birds (13.2%) of 28 species carried cefotaxime-resistant isolates; 58 of them (8.7%) carried extended-spectrum β-lactamases (ESBLs) and 15 (2.5%) plasmid-mediated AmpCs of the blaCIT family. The 58 ESBLs belonged to the CTX-M-1 group (63...
May 21, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29768099/the-mcr-1-gene-has-no-effect-on-colistin-resistance-when-it-coexists-with-inactivated-mgrb-gene-in-klebsiella-pneumoniae
#4
Huichuan Zhang, Dongdong Zhao, Qiucheng Shi, Jingjing Quan, Xi Li, Yunsong Yu
The inactivated mgrB gene and the mcr-1 gene are important mechanisms of colistin resistance in Klebsiella pneumoniae and they are threats to the clinical use of colistin. In this study, mcr-1 gene was cloned into K. pneumoniae strains (XH209 and KP10) and their derived strains (XH209 M and KP10 M), which showed high-level resistance to colistin. The acquisition of the mcr-1 gene led to colistin resistance in XH209 and KP10, but the addition of mcr-1 gene did not cause change of colistin minimum inhibitory concentrations in the XH209 M and KP10 M...
May 16, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29757079/epidemiology-antimicrobial-resistance-and-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-clinical-bovine-mastitis-in-tunisia
#5
Mariem Saidani, Lilia Messadi, Alya Soudani, Monia Daaloul-Jedidi, Pierre Châtre, Faten Ben Chehida, Aymen Mamlouk, Wassim Mahjoub, Jean-Yves Madec, Marisa Haenni
Bovine mastitis is a major disease in dairy cattle that causes high economic losses annually. Staphylococci, streptococci, and coliforms are among the major pathogens responsible for such infections. While data on bovine mastitis are numerous in Europe where the efficacy of farm management was monitored, those are scarce in African countries. In this study, we reported the occurrence of Escherichia coli (118/372, 31.7%) and Klebsiella pneumoniae (77/372, 20.7%), two environmental pathogens known to cause bovine mastitis...
May 14, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29750597/dissemination-of-vana-type-enterococcus-faecium-isolates-in-hungary
#6
Szilvia Melegh, Adrienn Nyul, Krisztina Kovács, Tamás Kovács, Ágoston Ghidán, Zsuzsanna Dombrádi, Judit Szabó, Brigitta Berta, Virág Lesinszki, Judit Pászti, Ákos Tóth, Gyula Mestyán
Although vanA carrying Enterococcus faecium human clinical isolates have been rarely found in Hungary before 2012, they have been detected in continuously increasing numbers since then. To identify factors associated with their dissemination, we investigated the clonal relatedness and plasmids of 30 vanA carrying E. faecium isolates originating from different Hungarian healthcare institutions from 2012 to 2014. Molecular typing of the isolates (n = 30) was performed with pulsed-field gel electrophoresis (PFGE), multilocus sequence typing, Tn1546 polymerase chain reaction mapping, plasmid restriction fragment length polymorphism analysis, and sequencing...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29750595/long-term-low-frequency-cluster-of-a-german-imipenemase-1-producing-enterobacter-hormaechei-ssp-steigerwaltii-st89-in-a-tertiary-care-hospital-in-germany
#7
Andreas F Wendel, Sebastian Meyer, René Deenen, Karl Köhrer, Susanne Kolbe-Busch, Klaus Pfeffer, Matthias Willmann, Achim J Kaasch, Colin R MacKenzie
Enterobacter cloacae complex is a common cause of hospital outbreaks. A retrospective and prospective molecular analysis of carbapenem-resistant clinical isolates in a tertiary care center demonstrated an outbreak of a German-imipenemase-1 (GIM-1) metallo-beta-lactamase-producing Enterobacter hormaechei ssp. steigerwaltii affecting 23 patients between 2009 and 2016. Thirty-three isolates were sequence type 89 by conventional multilocus sequence typing (MLST) and displayed a maximum difference of 49 out of 3,643 targets in the ad-hoc core-genome MLST (cgMLST) scheme (SeqSphere+ software; Ridom, Münster, Germany)...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29750591/salmonella-species-persistence-and-their-high-level-of-antimicrobial-resistance-in-flooded-man-made-rivers-in-china
#8
Qifa Song, Danyang Zhang, Hong Gao, Junhua Wu
Man-made rivers, owing to proximity to human habitats, facilitate transmission of salmonellosis to humans. To determine the contamination situation by Salmonella in flooded man-made rivers and thereafter the exposure risk to public health, we investigated the prevalence of Salmonella species and their antimicrobial resistance in such rivers, as well as the relationship between the incidence of local infectious diarrhea cases and the number of Salmonella isolates from patients. After a heavy flood, 95 isolates of 13 Salmonella serotypes were isolated from 80 river water samples...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29750585/clustering-analysis-of-antibiograms-and-antibiogram-types-of-streptococcus-agalactiae-strains-from-tilapia-in-china
#9
Chan Liu, Juan Feng, Defeng Zhang, Yundan Xie, Anxing Li, Jiangyong Wang, Youlu Su
In view of the changing antibiotic-resistance profiles of Streptococcus agalactiae from tilapia in China, antimicrobial susceptibilities of 75 S. agalactiae strains were determined by the disc diffusion method, and cluster analyses of the antibiograms and antibiogram types were performed. All strains displayed multidrug resistance (MDR). The antimicrobial-resistance rates were highest (>90%) to aminoglycosides, sulfonamides, pipemidic acid, and norfloxacin, followed by penicillin, ampicillin, and ciprofloxacin (26...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29742052/clinical-and-drug-resistance-characteristics-of-new-pediatric-tuberculosis-cases-in-northern-china
#10
Ting Wang, Fang Dong, Qin-Jing Li, Qing-Qin Yin, Wen-Qi Song, Igor Mokrousov, Wei-Wei Jiao, A-Dong Shen
AIM: The aim of this study was to evaluate the clinical features and characteristics of drug resistance in newly diagnosed pediatric tuberculosis (TB) patients in northern China. METHODS: Mycobacterium tuberculosis isolates were collected from September 2010 to October 2016 at the Beijing Children's Hospital. Patients were divided into two groups (resistant to at least one drug and pan-susceptible) according to drug susceptibility testing (DST) results. RESULTS: A total of 132 new cases, mainly from northern China (87...
May 9, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29733265/effects-of-cage-farming-on-antimicrobial-and-heavy-metal-resistance-of-escherichia-coli-enterococcus-faecium-and-lactococcus-garvieae
#11
Mustafa Ture, Ilhan Altinok, Huseyin Alp
OBJECTIVE: To characterize antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) of Escherichia coli and Enterococcus faecium isolated from the sediment and Lactococcus garvieae isolated from fish. MATERIALS AND METHODS: The isolated bacteria were identified by sequencing 16S rRNA genes. After identification of the bacteria, tetracycline (tetA, tetB, tetD), erythromycin (ereA, ereB), sulfonamides (sulI, sulII), trimethoprim (dhfrA1), β-lactam (blaTEM , blaCTX , ampC), florfenicol (floR), and class 1 integron (Int1) resistance gene were then determined...
May 7, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29723122/antimicrobial-resistance-profiles-of-enterohemorrhagic-and-enteropathogenic-escherichia-coli-of-serotypes-o157-h7-o26-h11-o103-h2-o111-h8-o145-h28-compared-to-escherichia-coli-isolated-from-the-same-adult-cattle
#12
Maryse Michèle Um, Hubert Brugère, Monique Kérourédan, Eric Oswald, Delphine Bibbal
The aim of this study was to compare the antimicrobial resistance profiles of top five enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) to E. coli isolated from the fecal flora of the same adult cattle. Previous prevalence studies had led to the isolation by immunomagnetic separation (IMS) of 39 EHEC and 80 EPEC. Seven EHEC were resistant (17.9%), and six were multidrug resistant (MDR) (15.4%). None of the top five EHEC was resistant to azithromycin. Nine EPEC O26:H11 (11.3%) were resistant...
May 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708847/preliminary-study-on-the-antibacterial-activity-of-essential-oils-alone-and-in-combination-with-gentamicin-against-extended-spectrum-%C3%AE-lactamase-producing-and-new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-isolates
#13
Paweł Kwiatkowski, Agata Pruss, Bartłomiej Grygorcewicz, Bartosz Wojciuk, Barbara Dołęgowska, Stefania Giedrys-Kalemba, Ewa Kochan, Monika Sienkiewicz
AIM: The aim of the study was to investigate possible synergistic effects between several selected, commercially available essential oils and gentamicin against extended-spectrum β-lactamase (ESBL)-producing and New Delhi metallo-β-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae isolates. MATERIALS AND METHODS: ESBLs production was confirmed by double-disk synergy test. Isolates positive for blaNDM-1 gene were found among the tested strains. K. pneumoniae ATCC® BAA-1705™ strain was used as a control...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708846/distribution-of-aminoglycoside-modifying-enzymes-and-molecular-analysis-of-the-coagulase-gene-in-clinical-isolates-of-methicillin-resistant-and-methicillin-susceptible-staphylococcus-aureus
#14
Farhad Seyedi-Marghaki, Davood Kalantar-Neyestanaki, Fereshteh Saffari, Hossein Hosseini-Nave, Mohammad Moradi
Enzymatic alteration of aminoglycosides by aminoglycoside-modifying enzymes (AMEs) is the major mechanism of resistance to aminoglycosides. The purpose of this study was to determine the frequency of AME genes, staphylococcal chromosomal cassette mec (SCCmec) types, and molecular analysis of the coagulase (coa) gene in Staphylococcus aureus strains isolated from clinical specimens. Totally, 102 S. aureus were tested by disk diffusion and microbroth dilution methods for susceptibility to aminoglycosides. AMEs genes and SCCmec types were determined by multiplex polymerase chain reaction (PCR)...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708845/the-role-of-flies-in-the-maintenance-of-antimicrobial-resistance-in-farm-environments
#15
Akira Fukuda, Masaru Usui, Masashi Okamura, Hu Dong-Liang, Yutaka Tamura
Flies play an important role as vectors in the transmission of antimicrobial-resistant bacteria (ARB) and are hypothesized to transfer ARB between internal and external livestock housing areas. The aim of this study was to understand the role that flies may play in the maintenance of ARB in the farm environment. We first evaluated the fate of ingested antimicrobial-resistant Escherichia coli harboring a plasmid containing antimicrobial-resistance genes (ARGs) throughout the housefly (Musca domestica) life cycle, from adult to the subsequent F1 generation...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708840/prevalence-and-antimicrobial-susceptibility-of-ureaplasma-spp-and-mycoplasma-hominis-in-asymptomatic-individuals-in-korea
#16
Jin Bong Choi, Seung-Ju Lee, Mi-Kyung Lee, Sung-Jong Lee, Dong Choon Park, Hee Youn Kim, Dong Sup Lee, Hyun-Sop Choe
This study investigated the prevalence and antibiotic resistance of Ureaplasma spp. and Mycoplasma hominis isolated from asymptomatic individuals in Korea. Endocervical swabs from women and urine from men, from a total of 5,781 asymptomatic individuals, were analyzed using a Mycoplasma IST2 Kit. Of the 4,825 specimens tested from females, 486 (10.1%) were positive culture. In these positive specimens, 437 (9.1%) were positive only for Ureaplasma spp., 17 (0.4%) were positive only for M. hominis, and 32 (0.7%) were positive for both Ureaplasma spp...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708837/molecular-epidemiology-of-vancomycin-resistant-enterococcus-faecalis-and-enterococcus-faecium-isolated-from-clinical-specimens-in-the-northwest-of-iran
#17
Ali Jahansepas, Mohammad Ahangarzadeh Rezaee, Alka Hasani, Yaeghob Sharifi, Marjan Rahnamaye Farzami, Alireza Dolatyar, Mohammad Aghazadeh
This study was conducted to investigate the phenotypic and genotypic characteristics of vancomycin-resistant Enterococcus faecalis and Enterococcus faecium. Antibiotic resistance and virulence genes in the aforementioned resistant isolates were studied using the epsilometer (E)-test and polymerase chain reaction (PCR). These isolates were subjected to typing by pulsed-field gel electrophoresis (PFGE). Thirty vancomycin-resistant enterococci (VRE; 18.75%) were isolated from a total of 160 various clinical specimens cultured for any bacterial growth...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29708832/antimicrobial-resistance-of-thermotolerant-campylobacter-species-isolated-from-humans-food-producing-animals-and-products-of-animal-origin-a-worldwide-meta-analysis
#18
Marcelo L Signorini, Eugenia Rossler, Diego C Díaz David, Carolina R Olivero, Analía Romero-Scharpen, Lorena P Soto, Diego M Astesana, Ayelen P Berisvil, Jorge A Zimmermann, Marcia L Fusari, Laureano S Frizzo, María V Zbrun
The objective of this meta-analysis was to summarize available information on the prevalence of antimicrobial-resistant Campylobacter species in humans, food-producing animals, and products of animal origin. A number of multilevel random-effect meta-analysis models were fitted to estimate mean occurrence rate of antimicrobial-resistant thermotolerant Campylobacter and to compare them throughout the years and among the species, food-producing animals (i.e., bovine, pigs, broilers, hen, goat, and sheep), country of origin, sample type, methodology to determine the antimicrobial susceptibility, and the species of Campylobacter...
April 30, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29698126/whole-genome-sequencing-of-ndm-1-producing-st11-klebsiella-pneumoniae-isolated-in-a-private-laboratory-in-greece
#19
Georgios Meletis, Fani Chatzopoulou, Dimitrios Chatzidimitriou, Fani Tsingerlioti, Christina Botziori, Georgios Tzimagiorgis, Lemonia Skoura
The emergence and spread of NDM-1-encoding Klebsiella pneumoniae is causing worldwide concern, whereas a second epicenter of their dissemination after the Indian subcontinent is thought to be located in the Balkans. In this study, the complete genome sequencing of an NDM-1-producing ST11 K. pneumoniae isolated in a private laboratory in Greece is presented. The genome sequencing was performed on Illumina MiniSeq. Multilocus Sequence Typing was determined using a BLAST-based approach whereas antimicrobial resistance genes and plasmid replicons were identified by ResFinder and PlasmidFinder respectively...
April 26, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29694266/comparison-of-carba-np-direct-carbapenem-inactivation-method-and-%C3%AE-carba-tests-for-detection-of-carbapenemase-production-in-enterobacteriaceae
#20
Banu Bayraktar, Ayşe Barış, Gülşah Malkoçoğlu, Duygu Erdemir, Nur Kına
Rapid and accurate detection of carbapenemase-producing isolates are extremely important for management of antimicrobial therapy and the implementation of infection control measures. We evaluated the performance of Carba NP-direct, carbapenem inactivation method (CIM), and the commercial β-CARBA tests for detection of carbapenemase production in Enterobacteriaceae. Enterobacteriaceae isolates with previously characterized carbapenemase types (n = 110) and non-carbapenemase-producing Escherichia coli (n = 15) isolates were tested...
April 25, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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