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Oral Diseases

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https://www.readbyqxmd.com/read/29121437/a-novel-pitx2-mutation-in-non-syndromic-oro-dental-anomalies
#1
Narin Intarak, Thanakorn Theerapanon, Chupong Ittiwut, Kanya Suphapeetiporn, Thantrira Porntaveetus, Vorasuk Shotelersuk
OBJECTIVE: To identify oro-dental characteristics and genetic etiology of a family affected with non-syndromic oro-dental anomalies. SUBJECTS AND METHODS: Physical and oral features were characterised. DNA was collected from an affected Thai family. Whole exome sequencing was employed to identify the pathogenic variants associated with inherited oro-dental anomalies. The presence of the identified mutation was confirmed by Sanger sequencing. RESULTS: We observed unique oro-dental manifestations including oligodontia, retained primary teeth, taurodont molars, peg-shaped maxillary central incisors, high attached frenum with nodule, and midline diastema in the proband and her mother...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29121436/association-of-dental-and-maxillary-sinus-pathologies-with-ear-nose-and-throat-symptoms
#2
Rachel Horwitz Berkun, David Polak, Lior Shapira, Ron Eliashar
OBJECTIVES: To investigate the correlation between cone beam computerized tomography (CBCT) findings in the maxillary sinus, Ear-Nose-Throat (ENT) symptoms and dental pathologies in asymptomatic patients. MATERIALS AND METHODS: A total 81 patients were referred for CBCT and filled a standard ENT visual analog scale (VAS) questionnaire. CBCT images were analyzed for sinus ostium obstruction, Schneiderian membrane thickening, sinus floor turbidity and the presence of polyps...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29121431/outcomes-of-oral-lichen-planus-and-oral-lichenoid-lesions-treated-with-topical-corticosteroid
#3
M A Gonzalez-Moles, J A Gil-Montoya, L Gonzalez-Ruiz, P Ramos, M Bravo
OBJECTIVE: To determine corticosteroid treatment effectiveness in patients with Oral Lichen Planus/Oral Lichenoid Lesions (OLP/OLL). MATERIAL AND METHODS: Twenty-one OLP and eighty-one OLL patients received 0.05% clobetasol propionate (CP) or 0.05% triamcinolone acetonide (TA) in aqueous solution (AS) or orabase (OB), evaluating responses to treatment and follow-up compliance. RESULTS: Lesions were atrophic (72/102; 70.6%), extensive (58/100; 58%), producing eating difficulties (62/102; 60...
November 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29117466/dental-properties-ultrastructure-and-pulp-cells-associated-with-a-novel-dspp-mutation
#4
Thantrira Porntaveetus, Thanaphum Osathanon, Nunthawan Nowwarote, Prasit Pavasant, Chalurmpon Srichomthong, Kanya Suphapeetiporn, Vorasuk Shotelersuk
OBJECTIVE: To investigate physical characteristics and behaviours of dental pulp cells of teeth isolated from a dentinogenesis imperfecta (DGI) patient with a novel DSPP mutation. SUBJECTS AND METHODS: Whole exome and Sanger sequencing were employed to identify mutations. Physical characteristics of the teeth were examined. Pulp cells' behaviors including cell proliferation, colony forming unit, osteogenic differentiation, pluripotent markers, and mesenchymal stem cell markers were investigated...
November 8, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29117464/salivary-scintigraphy-for-sj%C3%A3-gren-s-syndrome-in-patients-with-xerostomia-a-retrospective-study
#5
Marion Nadal, Maeva Levy, Aquib Bakhsh, Aline Joly, Annabel Maruani, Loïc Vaillant, Benoît Erra, Mahtab Samimi
OBJECTIVES: The value of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome remains controversial. The primary aim of this study was to estimate the diagnostic accuracy of salivary gland scintigraphy in the diagnosis of Sjögren's syndrome among 237 patients with xerostomia. METHODS: We retrospectively compared eight scintigraphy parameters between 106 Sjögren patients and 131 non-Sjögren patients. RESULTS: Seven of the eight parameters were significantly decreased in Sjögren patients; however their diagnostic accuracy was low, with AUCs ranging from 0...
November 8, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29095552/mirna-expression-profile-of-mucoepidermoid-carcinoma
#6
Nada O Binmadi, John R Basile, Paola Perez, Alessia Gallo, Mayank Tandon, Wael Elias, Shyh-Ing Jang, Ilias Alevizos
OBJECTIVES: MicroRNAs (miRNAs) are single-stranded RNAs that have been implicated in cancer initiation and progression and act as tumour suppressors or oncogenes. In this study, miRNA profiling was conducted on the most frequent malignancy of salivary glands, mucoepidermoid carcinoma (MEC), with comparison to normal tissues. MATERIALS AND METHODS: The TaqMan Human miRNA Cards Array was used for the miRNA profiling of MEC and normal tissues. To validate the differentially expressed miRNAs in MEC, we used real-time PCR (qRT-PCR)...
November 2, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29080392/plumbagin-mediating-glut1-suppresses-the-growth-of-human-tongue-squamous-cell-cancer
#7
Sijia Na, Jie Zhang, Xiongming Zhou, Anqun Tang, Deqiang Huang, Qichao Xu, Danfeng Xue, Jiaxuan Qiu
OBJECTIVE: The purpose of this study is to investigate the clinical and histopathological characteristics of GLUT1 in human tongue squamous cell carcinoma (TSCC) and the role of Plumbagin (PLB) mediating GLUT1 in the growth of TSCC. SUBJECTS AND METHODS: 45 cases of TSCC samples were collected and the expression and location of GLUT1 was analyzed. The role and mechanism of PLB meditating GLUT1 in the inhibitory growth of human TSCC cell line CAL27 was investigated in vitro and vivo...
October 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29069539/low-intensity-pulsed-ultrasound-stimulation-for-mandibular-condyle-osteoarthritis-lesions-in-rats
#8
Akemi Kanaguchi Arita, Ikuo Yonemitsu, Yuhei Ikeda, Mutsumi Miyazaki, Takashi Ono
OBJECTIVE: This study evaluated low-intensity pulsed ultrasound effects for temporomandibular joint osteoarthritis in adult rats. MATERIAL AND METHODS: Osteoarthritis-like lesions were induced in 24 adult rats' temporomandibular joints with low-dose mono-iodoacetate injections. The rats were divided into four groups: control and mono-iodoacetate groups, injected with contrast media and mono-iodoacetate, respectively, at 12 weeks and observed until 20 weeks; and low-intensity pulsed ultrasound and mono-iodoacetate + low-intensity pulsed ultrasound groups, injected with contrast media and mono-iodoacetate, respectively, at 12 weeks with low-intensity pulsed ultrasound performed from 16-20 weeks...
October 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29029370/elder-neglect-oral-diseases-and-injuries
#9
Stefano Petti
Elder Neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandatory in many countries. However, only few claims are substantiated, as EN could be confused with Self-Neglect, neglect could be unintentional or due to caregiver unawareness. Screening tools are inaccurate and their use is discouraged by public health organizations, because they lead to too many false positives, which engulf the already overwhelmed APSs...
October 13, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28994220/bacteremia-after-supragingival-scaling-and-dental-extraction-culture-and-molecular-analyses
#10
Luciana Carvalho Reis, Isabela N Rôças, José F Siqueira, Milton de Uzeda, Vane S Lacerda, Regina Maria Cavalcanti Pilotto Domingues, Karla Rodrigues Miranda, Roberto M Saraiva
OBJECTIVE: To study the incidence and magnitude of bacteremia after dental extraction and supragingival scaling. SUBJECTS AND METHODS: Blood samples were taken before and 5 and 30 minutes after dental extraction and supragingival scaling from individuals at high (n=42) or negligible risk (n=53) for infective endocarditis. The former received prophylactic antibiotic therapy. Samples were subjected to aerobic and anaerobic culture and quantitative real-time polymerase chain reaction to determine the incidence of bacteremia and total bacterial levels...
October 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28992378/grem2-nucleotide-variants-and-the-risk-of-tooth-agenesis
#11
Adrianna Mostowska, Barbara Biedziak, Małgorzata Zadurska, Agnieszka Bogdanowicz, Aneta Olszewska, Katarzyna Cieślińska, Ewa Firlej, Paweł P Jagodziński
OBJECTIVE: The etiology of tooth agenesis is multifactorial and still not fully understood. The aim of the study was to test whether variants of GREM2, encoding a BMP antagonist, are associated with the risk of this common dental anomaly in a Polish population. SUBJECTS AND METHODS: Direct sequencing of the GREM2 coding sequence including exon/intron boundaries was performed in 95 patients with both hypodontia and oligodontia. All identified GREM2 variants were then further tested in an independent group of patients (n=163) and controls (n=184)...
October 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28975726/muscle-fiber-diameter-assessment-in-cleft-lip-using-image-processing
#12
Mohammad Faisal Jamal Khan, Julian Little, Luigi Abelli, Peter Anthony Mossey, Luca Autelitano, Tapas Chandra Nag, Michele Rubini
OBJECTIVE: To pilot investigation of muscle fiber diameter (MFD) on medial and lateral sides of the cleft in 18 infants with cleft lip with or without cleft palate (CL/P) using image processing. MATERIAL AND METHODS: Formalin-fixed paraffin embedded (FFPE) tissue samples from the medial and lateral sides of the cleft were analyzed for MFD using an image processing program (ImageJ). For within-case comparison a paired student's test was performed. For comparisons between classes an unpaired t-test was used...
October 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28949432/the-use-of-crack-and-other-illicit-drugs-impacts-oral-health-related-quality-of-life-in-brazilians
#13
Raquel Pippi Antoniazzi, Fabricio Batistin Zanatta, Thiago Machado Ardenghi, Carlos Alberto Feldens
OBJECTIVE: The aim of the present study was to investigate the impact of the use of crack and other illicit drugs on oral health-related quality of life (OHRQoL) in young adults. METHODS: This cross-sectional study evaluated 106 crack users at a public treatment center for drug addiction and 106 controls matched for gender, age, and use of tobacco. Clinical examinations were performed for dental caries and periodontal disease. The outcome was OHRQoL, which was determined using the Oral Health Impact Profile (OHIP-14)...
September 26, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28944599/resveratrol-suppresses-the-alveolar-bone-resorption-induced-by-artificial-trauma-from-occlusion-in-mice
#14
Y Matsuda, T Minagawa, T Okui, K Yamazaki
OBJECTIVE: Besides inflammatory bone loss, trauma from occlusion (TO)-induced alveolar bone loss increases the risk of future tooth loss. We have shown that resveratrol, a polyphenol, possesses anti-inflammatory characteristics and a suppressive effect on osteoclastogenesis. Therefore, we investigated the effects of resveratrol on TO-induced bone loss in mice. MATERIAL AND METHODS: TO was induced by overlaying composite resin onto the maxillary first molar of C57BL/6 mice...
September 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28944591/the-impact-of-muc5b-gene-on-dental-caries
#15
Tayla Cavallari, Heloísa Salomão, Simone Tetu Moysés, Samuel Jorge Moysés, Renata Iani Werneck
OBJECTIVE: To identify the impact of MUC5B polymorphisms on dental caries. METHODS: A case-control study was performed with patients recruited at Pontifícia Universidade Católica do Paraná. This individuals were aged 12 years old or more. Dental caries was diagnosed using the International Caries Detection and Assessment System and the effects of socioeconomic, dietary, and hygiene factors on dental caries were investigated. Furthermore, buccal cells were collected, and their DNA was extracted and amplified using PCR...
September 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28941018/role-of-non-coding-rnas-in-head-and-neck-squamous-cell-carcinoma-a-narrative-review
#16
REVIEW
M K Sannigrahi, Rajni Sharma, Naresh K Panda, Madhu Khullar
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides), responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor-suppressors miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and, have been also implicated in carcinogenesis...
September 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28922514/the-complexity-of-oral-physiology-and-its-impact-on-salivary-diagnostics
#17
Eva J Helmerhorst, Colin Dawes, Frank G Oppenheim
OBJECTIVES: Saliva contains biomarkers for systemic as well as oral diseases. This study was undertaken to assess the variability in the sources of such biomarkers (plasma, cells), and attempted to identify saliva deterioration markers in order to improve saliva diagnostic outcomes. MATERIALS AND METHODS: Inter- and intra-subject variation in salivary gingival crevicular fluid levels were determined by measuring salivary albumin and transferrin levels. The purity of collected glandular secretions was determined by bacterial culture, and the variability in epithelial cell numbers by cell counting and optical density measurement...
September 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28898520/sugars-and-beyond-the-role-of-sugars-and-the-other-nutrients-and-their-potential-impact-on-caries
#18
REVIEW
Rodrigo A Giacaman
The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugar in caries. In fact, current definition points towards an ecological disease caused by the commensal microbiota that under ecological imbalances, mainly due to high and or frequent sugar consumption, creates a state of dysbiosis in the oral biofilm...
September 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28898513/characterisation-of-a-sucrose-independent-in-vitro-biofilm-model-of-supragingival-plaque
#19
Kota Tsutsumi, Masato Maruyama, Akira Uchiyama, Ken-Ichiro Shibasaki
OBJECTIVES: Sugar consumption has been decreasing in Japan, suggesting higher rates of sucrose-independent supragingival plaque formation. For developing an in vitro biofilm model of sucrose-independent supragingival plaque, this study aimed to investigate the compositions and functions on contributing to cariogenicity in comparison with sucrose-dependent biofilm. MATERIALS AND METHODS: An in vitro multispecies biofilm containing Actinomyces naeslundii, Streptococcus gordonii, S...
September 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28889479/associations-of-oral-fluid-mmp-8-with-periodontitis-in-swiss-adult-subjects
#20
M Mauramo, A M Ramseier, E Mauramo, A Buser, T Tervahartiala, T Sorsa, T Waltimo
OBJECTIVE: MMP-8 is a prominent collagenase in periodontal disease. This cross-sectional study examined whether MMP-8 levels in saliva and gingival crevicular fluid (GCF) are associated with periodontitis in a Swiss population. SUBJECTS AND METHODS: A total of 258 subjects (107 m, 151 f, mean age: 43.5 yr; range: 21-58 yr) acquired from the Swiss bone marrow donor registry participated in the study. Saliva and GCF samples were collected from subjects followed by a thorough dental and periodontal examination...
September 10, 2017: Oral Diseases
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