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Oral Diseases

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https://www.readbyqxmd.com/read/28231625/experimental-study-on-1-25-oh-2-d3-amelioration-of-oral-lichen-planus-through-regulating-nf-%C3%AE%C2%BAb-signaling-pathway
#1
Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang
OBJECTIVE: To explore the protective function of vitamin D (VD)/vitamin D receptor (VDR) on the development of oral lichen planus (OLP) and elaborate the underling mechanism of it. METHODS: H&E staining, myeloid Peroxidase (MPO) assays, quantitative PCR (qPCR), western blotting and Elisa were used to test the human biopsies and serum. QPCR, western blotting, Elisa and siRNA transfection were also performed in LPS-induced keratinocytes to observe the functions of vitamin D and VDR...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28231622/gingival-crevicular-fluid-levels-of-monocyte-chemoattractant-protein-mcp-1-in-patients-with-aggressive-periodontitis
#2
Sadiye Gunpinar, Nilgun Ozlem Alptekin, Niyazi Dundar
OBJECTIVES: The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of Monocyte Chemoattractant Protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP. MATERIAL AND METHODS: A total of 160 subjects including, 80 AgP and 80 age and gender matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP and 80 H...
February 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28199766/dysbiosis-of-oral-buccal-mucosa-microbiota-in-patients-with-oral-lichen-planus
#3
Yuan He, Diping Gong, Cong Shi, Fangyang Shao, Jiahao Shi, Jian Fei
OBJECTIVE: The bacterial community structure of buccal mucosa in patients with oral lichen planus was evaluated and compared with healthy control. SUBJECTS AND METHODS: Buccal scraping samples have been taken on 43 oral lichen planus patients (21 erosive and 22 non-erosive) and 21 mucosal healthy volunteers. The V3 hypervariable 16S rDNA region were amplified and sequenced by high-throughput 454 pyrosequencing. RESULTS: 94.26% of the total buccal bacteria were classified into 15 abundant genera...
February 15, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28190296/epstein-barr-virus-in-the-pathogenesis-of-oral-cancers
#4
Joseph T Guidry, Christine E Birdwell, Rona S Scott
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that establishes a lifelong persistent infection in the oral cavity and is intermittently shed in the saliva. EBV exhibits a biphasic life cycle, supported by its dual tropism for B lymphocytes and epithelial cells, which allows the virus to be transmitted within oral lymphoid tissues. While infection is often benign, EBV is associated with a number of lymphomas and carcinomas that arise in the oral cavity and at other anatomical sites. Incomplete association of EBV in cancer has questioned if EBV is merely a passenger or a driver of the tumorigenic process...
February 11, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28181739/absence-of-the-frequently-reported-pik3ca-casp8-and-notch1-mutations-in-south-indian-oral-cancers
#5
Ganesan Arunkumar, Avaniyapuram Kannan Murugan, Maharajan Nagarajan, Chandrasekar Ajay, Ramamurthy Rajaraman, Arasambattu Kannan Munirajan
OBJECTIVES: Somatic mutations of the PIK3CA, CASP8 and NOTCH1 have been frequently detected in various human cancers. Our study aims to analyze the mutational status of these genes in South Indian oral cancers. SUBJECTS AND METHODS: We performed mutational analysis of the PIK3CA (exons 9 & 20), CASP8 (exon 9) and NOTCH1 (exons 5, 6, 7, 8 & 9) genes in 96, 48 and 44 oral cancer samples, respectively. All the specified exons were PCR (polymerase chain reaction) amplified and directly sequenced by Sanger sequencing...
February 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28178402/salivary-levels-of-interleukin-8-and-growth-factors-are-modulated-in-patients-with-geographic-tongue
#6
Amal Dafar, Maria Bankvall, Vegard Garsjö, Mats Jontell, Hülya Çevik-Aras
OBJECTIVES: The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with geographic tongue (GT), as compared to control subjects. METHODOLOGY: An enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of IL-8, EGF, and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender, and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers...
February 8, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28168771/recent-updates-on-electronic-cigarette-aerosol-and-inhaled-nicotine-effects-on-periodontal-and-pulmonary-tissues
#7
REVIEW
Fawad Javed, Sergio V Kellesarian, Isaac K Sundar, Georgios E Romanos, Irfan Rahman
E-cigarette derived inhaled nicotine may contribute to the pathogenesis of periodontal and pulmonary diseases in particular via lung inflammation, injurious and dysregulated repair responses. Nicotine is shown to have anti-proliferative properties and affects fibroblasts in vitro, which may interfere in tissue myofibroblast differentiation in e-cig users. This will affect the ability to heal wounds by decreasing wound contraction. In periodontics, direct exposure to e-vapor has been shown to produce harmful effects in periodontal ligament and gingival fibroblasts in culture...
February 6, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28168769/topical-tacrolimus-triamcinolone-acetonide-and-placebo-in-oral-lichen-planus-a-pilot-randomized-controlled-trial
#8
M Siponen, L Huuskonen, S Kallio-Pulkkinen, P Nieminen, T Salo
OBJECTIVE: To carry out a double-blind RCT to compare the effectiveness of topical tacrolimus (TAC), triamcinolone acetonide (TRI) and placebo (PLA) in symptomatic OLP. SUBJECTS AND METHODS: A clinical score (CS, range 0-130) was developed to measure the clinical signs and symptoms of OLP. Twenty-seven OLP patients with a CS of ≥ 20 were randomly allocated to receive 0.1% TAC ointment (n=11), 0.1% TRI paste (n=7) or Orabase(®) paste as PLA (n=9) for 3 weeks. If the CS dropped ≥ 20% (interpreted as response), the patients continued the same medication for another 3 weeks...
February 6, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28160766/phenytoin-induced-gingival-overgrowth-caused-by-death-receptor-pathway-malfunction
#9
Reiri Takeuchi, Hiroko Matsumoto, Kazumune Arikawa, Chieko Taguchi, Ryuji Nakayama, Ikuo Nasu, Koichi Hiratsuka
OBJECTIVE: In this study, we investigated the role of phenytoin (PHT) in death receptor-induced apoptosis of gingival fibroblasts to clarify the mechanism of PHT-induced gingival overgrowth. METHODS: Human gingival fibroblasts were cultured to semi-confluence and treated with PHT (0.025, 0.1, 0.25, and 1.0 μM) for 48 h, and then the apoptotic cell numbers were relatively determined by absorptiometry. After 24 h of 0.25 μM PHT treatment, caspase activity was measured by absorptiometry, apoptotic and cell cycle phase distribution was analyzed by flow cytometry, expression levels of apoptotic genes were quantified by real-time qPCR, and expression of apoptotic proteins was detected by western blot analysis...
February 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28142227/experimental-comparison-between-tractional-and-compressive-stress-on-temporomandibular-joint
#10
Shinnosuke Nogami, Kensuke Yamauchi, Yoshinaka Shimizu, Bunichi Hirayama, Akira Kumasaka, Masahiro Iikubo, Hiroyuki Kumamoto, Tetsu Takahashi
OBJECTIVE: We experimentally compared the effects of compressive and tractional mechanical stress on the temporomandibular joint (TMJ) of rabbits to assess the etiology of progressive condylar resorption. MATERIALS AND METHODS: We performed a cortical osteotomy using custom-made devices that were lengthened by 0.25 mm every 12 h for 1 week after surgery. During this time, the rabbit TMJ was under compressive or tractional mechanical stress. The samples in each group were examined using micro-computed tomography and histological staining...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28142222/flagellar-filament-structural-protein-induces-sj%C3%A3-gren-s-syndrome-like-sialadenitis-in-mice
#11
Tomoaki Higuchi, Ikuko Haruta, Noriyuki Shibata, Naoko Yanagisawa, Junji Yagi
OBJECTIVE: Sjögren's syndrome (SS) is a systemic autoimmune disease that primarily affects lacrimal and salivary glands. We previously reported that FliC derived from E. coli could induce autoimmune pancreatitis-like lesions. From these results, we speculated that FliC could also induce SS-like exocrinopathy. In the present study, we investigated the effects of chronic exposure to FliC on lacrimal and salivary glands and the possibility that it might lead to an autoimmune response. METHODS: C57BL/6 mice were repeatedly injected with FliC and histological changes, serum levels of cytokine/chemokines and autoantibodies were evaluated at different time points after the final injection...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28142218/differential-effects-of-the-combination-of-tyrosol-with-chlorhexidine-gluconate-on-oral-biofilms
#12
Luana Ribeiro do Vale, Alberto Carlos Botazzo Delbem, Laís Salomão Arias, Renan Aparecido Fernandes, Ana Paula Miranda Vieira, Débora Barros Barbosa, Douglas Roberto Monteiro
OBJECTIVE: This study assessed the effect of tyrosol and chlorhexidine gluconate in combination against Candida albicans, Candida glabrata and Streptococcus mutans in the planktonic state or forming biofilms in vitro. MATERIALS AND METHODS: Checkerboard assays were performed for determination of minimum inhibitory concentration. Biofilms were cultivated during 24 h on specimens of acrylic resin and hydroxyapatite, and treated with the drugs alone or in combination twice a day for 1 min, during 3 days...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28142213/ameloblastoma-current-etiopathological-concepts-and-management
#13
Olajumoke A Effiom, Oladunni M Ogundana, Abdulwarith O Akinshipo, Sunday O Akintoye
Ameloblastoma is a benign odontogenic tumor of epithelial origin. It is locally aggressive with unlimited growth capacity and has a high potential for malignant transformation as well as metastasis. Ameloblastoma has no established preventive measures although majority of patients are between ages 30 to 60 years. Molecular and genetic factors that promote oncogenic transformation of odontogenic epithelium to ameloblastoma are strongly linked to dysregulation of multiple genes associated with mitogen activated protein kinase, sonic hedgehog and WNT/β-catenin signaling pathways...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28142210/geriatric-oral-and-maxillofacial-dysfunctions-in-the-context-of-geriatric-syndrome
#14
REVIEW
Yoon Nam, Nam-Hee Kim, Hong-Seop Kho
OBJECTIVES: To propose the application of the concept of geriatric syndrome for common geriatric oral and maxillofacial dysfunctions and to suggest the necessity of developing effective evaluation methods for oral and maxillofacial frailty. DESIGN: The concepts of frailty and geriatric syndrome based on multi-morbidity and polypharmacy were applied to five common geriatric oral medicinal dysfunctional problems: salivary gland hypofunction (dry mouth), chronic oral mucosal pain disorders (burning mouth symptoms), taste disorders (taste disturbances), swallowing disorders (dysphagia), and oral and maxillofacial movement disorders (oromandibular dyskinesia and dystonia)...
January 31, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28130802/next-step-functional-studies-on-hypertension-lichen-planus-and-trpa1-connections
#15
LETTER
Jozsef Kun
We would like to thank for the invaluable insights of Shan and colleagues (Shan et al, 2017). They put forward a most logical hypothesis for a link between Koebner phenomenon and the mechanoreceptor Transient Receptor Potential Ankyrin 1 (TRPA1). As suggested, TRPA1 expression in non-lesion mucosal areas of oral lichen planus (OLP) patients should also be investigated. Furthermore, buccal samples form people displaying mursicatio buccarum may be used to test if prolonged mechanical stimuli alone upregulate TRPA1 in the oral mucosa...
January 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28120363/elderly-with-remaining-teeth-report-less-frailty-and-better-quality-of-life-than-edentulous-elderly-a-cross-sectional-study
#16
A R Hoeksema, S L W Spoorenberg, L L Peters, H J A Meijer, G M Raghoebar, A Vissink, K Wynia, A Visser
OBJECTIVE: To assess oral status and self-reported oral health in community-living elderly and to determine differences between relevant subgroups of oral status (remaining teeth, edentulous, implant-retained overdentures) and case complexity (robust, frail, complex care needs). SUBJECTS AND METHODS: In this cross-sectional descriptive study, 1325 Dutch community-living elderly (≥75 years of age) were asked to complete validated questionnaires on frailty, ADL, complexity of care needs and QoL...
January 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28117549/rebamipide-an-anti-ulcerative-drug-inhibits-induction-of-salivary-dysfunction-by-benzodiazepines
#17
Makoto Ogane, Migiwa Okubo, Masanobu Yoshikawa, Takashi Shinomiya, Eri Tsukagoshi, Mitsuru Kawaguchi
OBJECTIVES: The purpose of this study was to determine whether rebamipide, an anti-stomach ulcer agent, ameliorated benzodiazepine-induced hyposalivation in rat parotid gland (PG) and submandibular gland (SMG). METHODS: Saliva was collected from PG and SMG through a capillary cannula inserted into the parotid duct and sublingual papillae, respectively, every 15 min for 1 hr after stimulation with pilocarpine dissolved in physiological saline and intraperitoneally administered at 1 mg/kg...
January 24, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28117540/cathepsin-k-modulates-invasion-migration-and-adhesion-of-oral-squamous-cell-carcinomas-in-vitro
#18
Kentaro Yamashita, Mayumi Iwatake, Kuniaki Okamoto, Shin-Ichi Yamada, Masahiro Umeda, Takayuki Tsukuba
OBJECTIVE: Cathepsin K was initially discovered as an osteoclast-specific cysteine proteinase, but the enzyme is also expressed in various cancers including oral squamous cell carcinomas. The present study aimed to clarify the function of cathepsin K in oral squamous cell carcinomas. MATERIALS AND METHODS: Expression levels of cathepsin K were examined in six types of cell carcinomas. Carcinomas overexpressing cathepsin K were constructed. Effects of cathepsin K overexpression and treatment with odanacatib, a specific cathepsin K inhibitor, on cell invasion, migration, and adhesion were analysed...
January 24, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28107582/immunoexpression-of-hdac1-hdac2-and-hat1-in-actinic-cheilitis-and-lip-squamous-cell-carcinoma
#19
Emanuely da Silva Chrun, Filipe Modolo, Daniella Serafim Couto Vieira, Álvaro Luiz Socorro Borges, Renata Goulart Castro, Filipe Ivan Daniel
BACKGROUND: Acetylation/deacetylation are the most studied covalent histone modifications resulting in transcriptional regulation with histone deacetylases (HDAC) and histone acetyltransferases (HAT) as the main associated enzymes. These enzymes overexpression induces abnormal transcription of key genes that regulate important cellular functions, such as proliferation, cell cycle regulation, and apoptosis. Thus, the expression of different HATs and HDACs has been evaluated in various cancers...
January 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28084005/oral-mucous-membrane-pemphigoid-and-pemphigus-vulgaris-a-retrospective-two-center-cohort-study
#20
Ahmed S Sultan, Alessandro Villa, Arturo P Saavedra, Nathaniel S Treister, Sook-Bin Woo
OBJECTIVES: Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement and management outcomes were performed. SUBJECTS AND METHODS: Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included. RESULTS: There were 26 MMP (46%) and 31 PV (54%) patients. Desquamative gingivitis was evident in 84% of MMP cases compared to 26% of PV cases (p<0...
January 13, 2017: Oral Diseases
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