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Oral Diseases

Amirsalar Mofidi, Dongdong Fang, Carlos Flores-Mir
Although daily cannabis use is not relatively prevalent in the general population (1.8%), it is the most commonly used illicit drug in Canada.(Rotermann & Langlois, 2015) Various age cohorts engage in the activity, with the clear majority being clustered in youth and adults between the ages of 15-44.(Rotermann & Langlois, 2015) Cannabis once an ostracized illegal drug is now undergoing a frameshift in North American culture with many states in the United States legalizing the recreational use of the drug, and the imminent legalization status that may ensue shortly in Canada...
September 21, 2018: Oral Diseases
Marcela Maria Osorio Parra, Elangovan Satheesh, Chun-Teh Lee
Recently, several studies demonstrated the potential of using specialized pro-resolving lipid mediators (SPMs), as a novel approach, in treating periodontitis in pre-clinical models. This review aimed to systematically evaluate the biological actions of SPMs on periodontal tissues in animals with experimentally induced periodontitis. This systematic review was performed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies were searched in three databases...
September 19, 2018: Oral Diseases
Amy Ming-Fang Yen, Sen-Te Wang, Sheng-Wei Feng, Che-Tong Lin, Sam Li-Sheng Chen
OBJECTIVES: The present study is to investigate the association between fecal hemoglobin (f-Hb) concentration and oral cancer and its precursor, oral potentially malignant disorders (OPMD). METHODS: We used a population-based longitudinal cohort study data based on both Taiwanese nationwide oral and colorectal cancer screening programs implemented between 2004 and 2009. The total of 235,234 smokers and/or betel quid chewers aged 50-69 years free of oral cancer and OPMD at entry were followed up over time to quantify the association between baseline f-Hb concentration on newly diagnosed oral cancer and OPMD...
September 14, 2018: Oral Diseases
Eva María Otero Rey, Anabel Yáñez-Busto, Inés Filipa Rosa Henriques, José López-López, Andrés Blanco-Carrión
OBJECTIVE: The aim of this study is to perform a systematic review and meta-analysis answering the following questions: a) "What is the prevalence and risk of oral lichen planus among patients with diabetes mellitus?" and b) "What is the prevalence and risk of diabetes mellitus among patients with oral lichen planus?". MATERIAL AND METHODS: A bibliographic search was conducted in PubMed/Medline and Scopus database from 1966 to March 2018, using the following terms: "Lichen planus" AND "Diabetes mellitus" AND "Prevalence" AND "Oral mucosal lesions"...
September 11, 2018: Oral Diseases
Isaäc van der Waal
At present, oral leukoplakia has been defined as "a predominantly white plaque of questionable risk having excluded (other) known diseases or disorders that carry no increased risk for cancer" (Warnakulasuria, 2007). A diagnosis of oral leukoplakia is probably often based on clinical judgement alone. The indication for a biopsy may be 1) to exclude (other) known diseases or, 2) in case of a strong suspicion of the a diagnosis of leukoplakia, to assess the presence and degree of epithelial dysplasia and to exclude the possible presence of squamous cell carcinoma, carcinoma in situ or verrucous carcinoma...
September 11, 2018: Oral Diseases
Lucimara T Neves, Thiago J Dionísio, Thais F Garbieri, Viviane A Parisi, Fernanda V Oliveira, Thais M Oliveira, Carlos F Santos
OBJECTIVE: Subjects with cleft lip and palate (CLP) present high prevalence of dental agenesis. Among candidate genes for these phenotypes, IRF6. However, genetic studies do not analyze dental agenesis as a phenotype associated with cleft. Therefore, we investigated the frequency of rare and novel variations in IRF6 in subjects with nonsyndromic unilateral cleft lip and palate (NSUCLP), with and without dental agenesis. SUBJECTS AND METHODS: Genomic DNA samples of 100 subjects with NSUCLP with and without dental agenesis and 50 controls were sequenced...
September 8, 2018: Oral Diseases
Katarzyna Ksiazek, Jerzy Blaszczak, Monika Buraczynska
OBJECTIVE: Interleukin-4 gene polymorphisms were found to be associated with periodontitis. The purpose of this case-control study was to evaluate association of IL4 VNTR polymorphism with periodontitis in patients with end-stage renal disease (ESRD). SUBJECTS AND METHODS: We examined 180 ESRD patients with chronic periodontitis, 82 without CP and 180 healthy controls. Genomic DNA from all subjects was genotyped for the IL4 VNTR polymorphism by polymerase chain reaction (PCR)...
September 8, 2018: Oral Diseases
Omer Cakmak, Banu Arzu Alkan, Ebru Saatci, Zekeriya Tasdemir
OBJECTIVES: The purpose of this prospective study was to investigate the effect of nonsurgical periodontal treatment (PT) on anxiety/depression scale scores and on gingival crevicular fluid (GCF) cortisol (COR) and dehydroepiandrosterone (DHEA) levels. METHODS: 55 participants with generalized chronic periodontitis (GCP group, n:21), localized chronic periodontitis (LCP group, n:19) and gingivitis/healthy(control group, n : 15) patients were treated and followed up for 6 months...
September 6, 2018: Oral Diseases
Jing Shan, Zhida Sun, Jingjing Yang, Juanyong Xu, Wei Shi, You Wu, Yuan Fan, Huaiqi Li
OBJECTIVES: Our aim was to identify and pre-validate a set of salivary proteins that can distinguish OSCC patients from healthy individuals and patients with oral potentially malignant disorders (OPMD). SUBJECTS AND METHODS: Proteomes of 60 saliva samples from healthy individuals, OPMD patients, and OSCC patients were assayed using the isobaric tags for relative and absolute quantitation (iTRAQ) method. Enzyme-linked immunosorbent assay (ELISA) were used to pre-validate the candidate biomarkers in an independent sample set (n = 90)...
August 31, 2018: Oral Diseases
Emrah Anbarcioglu, Tugrul Kirtiloglu, Ayla Ozturk, Filiz Kolbakir, Gokhan Acıkgoz, Ramis Colak
OBJECTIVES: Vitamin D deficiency is a frequent health problem worldwide, especially as fewer people spend much time in the sun. Vitamin D deficiency is linked to several infectious and inflammatory conditions, including periodontal disease. However, its role in aggressive periodontitis (AgP) has not been well studied. We evaluated the association between vitamin D concentration and periodontal disease, both AgP and chronic (CP) periodontitis. METHOD AND MATERIALS: 47 AgP 55 CP and 27 control subjects participated...
August 31, 2018: Oral Diseases
Di Wu, Gauri Khorjekar, Pejman Kharazi, Shari Moreau, Kanchan Kulkarni, Kenneth D Burman, Leonard Wartofsky, Douglas Van Nostrand
OBJECTIVES: To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from 131 I therapy in differentiated thyroid cancer patients. METHODS: Differentiated thyroid cancer patients who were clinically scheduled for an 131 I therapy at MedStar Washington Hospital Center between 2012 and 2013 were given instructions for continuous sialogogues per standard clinical protocol. The prospective survey was given at multiple time points...
August 31, 2018: Oral Diseases
Denise Hélen Imaculada Pereira de Oliveira, Éricka Janine Dantas da Silveira, Lélia Batista de Souza, Claudia Haydee S Caro Sanchez, Hugo Dominguez-Malagon, Adalberto Mosqueda Taylor, Lélia Maria Guedes Queiroz
OBJECTIVE: To immunohistochemically characterize a group of oral myofibroblastic lesions (MLs) and to evaluate the ultrastructural features of myofibroblasts. MATERIAL AND METHODS: Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1) and Ki-67...
August 31, 2018: Oral Diseases
Nurcan Buduneli
No abstract text is available yet for this article.
August 31, 2018: Oral Diseases
Yanhua Li, Ying Deng, Changfei Deng, Liang Xie, Li Yu, Lijun Liu, Yumei Yuan, Hanmin Liu, Li Dai
OBJECTIVE: To examine the possible associations between methylation changes in the promoter regions of long interspersed nucleotide element-1 (LINE-1) and interferon regulatory factor 6 gene (IRF6) and nonsyndromic cleft lip with or without cleft palate (NSCL/P). METHODS: A case-control investigation was performed to compare 37 infants affected by NSCL/Ps with 60 babies without cleft malformations. Their genomic DNA samples were obtained, and the LINE-1 and IRF6 methylation levels were measured by using Sequenom MassArray...
August 28, 2018: Oral Diseases
Sun-Young Jung, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon
OBJECTIVES: There is limited evidence regarding the appropriate length of a bisphosphonate (BP) holiday to reduce the risk of osteonecrosis of the jaw (ONJ). In this cross-sectional study, we investigated the population-based patterns of the gaps between BP discontinuation and ONJ diagnosis. SUBJECTS AND METHODS: We used the claims database of the National Health Insurance Service in Korea. Among BP users between 2006 and 2015, incident ONJ cases during 2010-2015 with no history of ONJ in the last four years were identified...
August 28, 2018: Oral Diseases
Chong Wang, Yuesong Pan, Qiaoshi Xu, Bo Li, Kim Kyojin, Minghui Mao, Jinzhong Li, Lizheng Qin, Hua Li, Zhengxue Han, Zhien Feng
OBJECTIVE: The purpose of our study was to investigate body mass index (BMI) as a prognostic factor and to examine the relationship between pretreatment BMI and oral squamous cell carcinoma (OSCC) outcomes in northern Chinese patients. METHODS: This retrospective study enrolled 633 patients with OSCC who underwent surgery between 2004 and 2014. RESULTS: Most baseline characteristics (gender, sites, smoking history, comorbidity, hypertension, T stage, clinical features, perineural invasion, flap reconstruction) were differentiated by BMI groups...
August 24, 2018: Oral Diseases
Camilla Kragelund, Mette Kirstine Keller
BACKGROUND: Several recent studies have investigated the oral bacteriome in oral lichen planus (OLP), but longitudinal changes in microbiome have not been investigated. OBJECTIVE: To study the bacteriome and mycobiome in OLP over a 1-year period and the impact of topical treatment. MATERIAL AND METHODS: Samples from 22 symptomatic OLP patients from a double-blinded, randomized intervention study were collected over a 1-year course at five visits...
August 24, 2018: Oral Diseases
Mohammad Faisal J Khan, Julian Little, Tapas Chandra Nag, Peter Anthony Mossey, Luca Autelitano, Maria Costanza Meazzini, Ahmed Merajuddin, Anuraag Singh, Michele Rubini
OBJECTIVE: A preliminary study to determine collagen fibril diameter (CF-ED) distribution on medial and lateral sides of cleft lip (CL). MATERIAL AND METHODS: Tissue samples from medial and lateral sides of CL were fixed in 2.5% glutaraldehyde and 1% osmium tetroxide and embedded in Araldite CY212 resin for transmission electron microscopy. The analysis of CF-ED was performed using the ImageJ program. To characterize the packaging of collagen fibrils (CFs) in the two tissues, we estimated the collagen number density (CF-ND) and fibril-area-fraction (FAF)...
August 24, 2018: Oral Diseases
Myung-Seop Shin, Yoo Jin Shin, Sandeep Karna, Hyun-Duck Kim
OBJECTIVE: As the era of aging comes, cognitive impairment (CI) is increasing. The impact of rehabilitation of lost tooth on CI remains unclear. This study aimed to investigate whether non-rehabilitated lost teeth (NRLT) is associated with CI among Korean elders. METHODS: A total of 280 elders comprising of 140 cases and 140 age-sex-matched controls were included in this cross-sectional study. CI was assessed using the Mini-Mental Status Examination (MMSE). NRLT was evaluated using panoramic radiograph and oral examination...
August 21, 2018: Oral Diseases
Ahoud Jazzar, Andiappan Manoharan, Jackie E Brown, Penelope J Shirlaw, Guy H Carpenter, Stephen J Challacombe, Gordon B Proctor
BACKGROUND: Salivary gland dysfunction is one of the main clinical features of Sjögren's syndrome (SS), manifested by xerostomia with subsequent complications and well-established effects on the person's quality of life. OBJECTIVES: To determine firstly whether selected tests of salivary gland function and structure, unstimulated whole salivary flow rate (UWSFR), parotid flow rate (PFR), clinical oral dryness score (CODS) and ultrasound score (USS), can discriminate SS from non-SS sicca patients and secondly whether these tests can differentiate between patients in different subgroups of SS...
August 18, 2018: Oral Diseases
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