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Oral Diseases

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https://www.readbyqxmd.com/read/28686335/infection-and-apoptosis-associated-with-inflammation-in-periodontitis-an-immunohistologic-study
#1
Dyah Listyarifah, Ahmed Al-Samadi, Abdelhakim Salem, Ahmad Syaify, Tuula Salo, Taina Tervahartiala, Daniel Grenier, Dan C Nordström, Timo Sorsa, Mari Ainola
OBJECTIVE: Evidence of increased apoptosis is observed in periodontitis, and may be associated with destruction of the periodontal tissue caused by the increased cell death, with the release of danger signals and subsequent stimulation of the proinflammatory processes. However, the exact mechanisms associated with these processes remain unclear. This study aimed to investigate the presence of the periodontal pathogen Treponema denticola, apoptosis, High Mobility Group Box1 as a damage-associated molecular pattern and several inflammatory markers in periodontitis and gingivitis subjects...
July 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28675770/oral-complications-at-six-months-after-radiation-therapy-for-head-and-neck-cancer
#2
Rajesh V Lalla, Nathaniel Treister, Thomas Sollecito, Brian Schmidt, Lauren L Patton, Kusha Mohammadi, James S Hodges, Michael T Brennan
OBJECTIVE: Examine oral complications 6 months after modern radiation therapy (RT) for head and neck cancer (HNC). METHODS: Prospective multi-center cohort study of HNC patients receiving Intensity-Modulated Radiation Therapy (IMRT) or more advanced RT. Stimulated whole salivary flow, maximal mouth opening, oral mucositis, oral pain, oral health-related quality of life (OH-QOL), and oral hygiene practices, were measured in 372 subjects pre-RT and 216 at 6 months from start of RT...
July 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28656643/risk-factors-for-medication-related-osteonecrosis-of-the-jaws-a-systematic-review
#3
REVIEW
Kelly McGowan, Troy McGowan, Saso Ivanovski
OBJECTIVE: The purpose of this study was to identify the patient populations at risk of medication related osteonecrosis of the jaw (MRONJ) and determine which medical and dental comorbidities are significant risk factors for this disease. METHODS: An electronic search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, WHO International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for MRONJ...
June 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28650087/educational-strategies-and-art-effect-on-salivary-characteristics-a-controlled-clinical-trial
#4
Camila Nobre de Freitas, Paula Midori Castelo, Karina Guedes de Sousa, Gabriela Caroline Alonso, Fernando Luiz Affonso Fonseca, Marlise Inês Klein, Taís de Souza Barbosa
OBJECTIVE: To evaluate educational strategies and ART-restoration impact on salivary physicochemical and microbiological characteristics. DESIGN: Two groups of 6-7-yr-old children were included: GART , with at least one decayed primary molar (n=36), submitted to 4 sessions of oral health educational strategy (OHES) and ART-restoration; GC , a paired caries-free group (n=36), submitted to 4 sessions of OHES. Three evaluations were carried out: baseline, one week after OHES and one month after OHES or ART, when biofilm and gingivitis frequencies, salivary flow, pH, buffer capacity, calcium and phosphorus concentrations were assessed...
June 26, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28650084/detection-of-human-polyomaviruses-jc-and-bk-in-liver-pre-transplant-patients
#5
Marilia A Figueiredo, Maria Cristina Domingues Fink, Talita Castro, Paulo Henrique Braz-Silva, Jeanne Carla Steffens, Fernanda de Paula Eduardo, Marina Gallottini, Karem L Ortega
OBJECTIVE: This study aimed to identify and quantify polyomaviruses (BKPyV and JCPyV) in the saliva, mouthwash, blood and urine of liver pre-transplant patients. MATERIALS & METHODS: A case-control study was performed using a convenience sample of 21 end-stage liver disease patients (EG = experimental group) and 20 normoreactive controls (CG = control group). In total, 162 samples were collected. Detection and quantification of polyomaviruses were performed by using real-time PCR method...
June 26, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28644570/clinical-and-genetic-analysis-of-patients-with-cherubism
#6
R A Machado, H A R Pontes, F R Pires, H M Silveira, A Bufalino, R Carlos, F M Tuji, D B M Alves, A R Santos-Silva, M A Lopes, H M Capistrano, R D Coletta, F P Fonseca
OBJECTIVE: To describe the clinical and genetic features of patients with cherubism. MATERIAL AND METHODS: A descriptive analysis of 14 cases from 9 different families was carried out. Clinicopathological, imaging and follow-up data were retrieved from patients' medical files and correlated with the genetic profile of each patient. Genomic DNA isolated from buccal mucosa cells was subjected to direct sequencing analysis of the SH3BP2 gene. RESULTS: Females were more affected than males (8:6), and the mean age at diagnosis was 8...
June 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28644543/osteogenic-potential-of-three-different-autogenous-bone-particles-harvested-during-implant-surgery
#7
Chao Liang, Xiao Lin, Song-Ling Wang, Li-Hua Guo, Xiao-Yu Wang, Jun Li
OBJECTIVES: The aim was to compare the osteoblast activity and osteogenic potential of autogenous bone particles harvested using three different techniques, determine the most advantageous method of collecting autogenous bone particles. SUBJECTS AND METHODS: Bone particles were harvested from 20 patients during dental implant surgery using bone scraping, low-speed drilling, and bone trap filtering. After the osteoblasts were cultured, cell proliferation, migration, mineralization, transcription of osteogenesis-related genes, secretion of osteogenesis-related proteins, and osteoinductive protein content in the bone particle matrix were evaluated...
June 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28636235/stem-cell-based-tooth-and-periodontal-regeneration
#8
Lei Hu, Yi Liu, Songlin Wang
Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
June 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28632321/is-aggregatibacter-actinomycetemcomitans-the-missing-link-between-periodontitis-and-rheumatoid-arthritis
#9
David Polak
The impact of chronic conditions on the modern population is even more evident in view of a prolonged human life span. In addition, most individuals will probably simultaneously suffer from more than one chronic condition. As such, unveiling the pathogenesis of chronic diseases, as well as the causal factors that crosstalk between different conditions, is one of the greatest challenges faced by modern medicine. Two such conditions are periodontitis and rheumatoid arthritis (RA). This article is protected by copyright...
June 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28627728/can-atrophic-erosive-oral-lichen-planus-promote-cardiovascular-diseases-a-population-based-study
#10
Davide Conrotto, Roberta Barattero, Mario Carbone, Alessio Gambino, Veronica Sciannameo, Fulvio Ricceri, Federico Conrotto, Roberto Broccoletti, Paolo G Arduino
OBJECTIVES: Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. SUBJECTS AND METHODS: Patients were analysed through a complete collection of all the risk factors for CVDs...
June 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28622437/detection-of-halitosis-in-breath-between-the-past-present-and-future
#11
M K Nakhleh, M Quatredeniers, H Haick
To develop a new generation of diagnostics for halitosis, replacing the subjective organoleptic assessment, a series of exhaled breath analyzers has been developed and assessed. All three devices rely on the assessment of exhaled volatile sulfuric compounds (VSCs), which are mainly generated in and emitted from the oral cavity, contributing to the malodor. Portable, on-site and easy to use, these devices have potential for non-invasive diagnosis of halitosis. However, global assessment of exhaled VSCs alone has two main drawbacks: (i) the absence of VSCs does not rule out halitosis; (ii) non-sulfuric volatile compounds that could be biomarkers of systemic diseases, found in up to 15% of halitosis cases, are neglected...
June 16, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28599095/mucojet-a-novel-oral-microjet-vaccination-system
#12
Craig S Miller, Richard N Greenberg
In a recent publication in Science Translational Medicine 9:1-9, Aran et al (2017) provide a series of elegant experiments that present an innovative noninvasive intraoral method for vaccination that uses a device termed MucoJet (Aran et al, 2017). Their findings delineate an easy to use system involving jet velocity to penetrate buccal mucosa and deliver a vaccine to underlying immune cells. This technology provides a launching pad for several potential innovations for healthcare. This article is protected by copyright...
June 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28580710/a-nomogram-for-predicting-the-risk-of-neck-node-metastasis-in-pathologically-node-negative-oral-cavity-carcinoma
#13
Sharada Sawant, Harsh Dongre, Chetan Ahire, Shilpi Sharma, Sadhana Kannan, Snehal Mahadik, Devendra Chaukar, Fatima Lukmani, Asawari Patil, Anil D'Cruz, Milind Vaidya, Prabhakar Dongre
OBJECTIVE: To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS: Surgically removed oral tumours (n=103) were analyzed for the expression of desmosomal and hemidesmosomal assembly proteins by immunohistochemistry and ultrastructural alterations by transmission electron microscopy (TEM)...
June 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28544064/obesity-is-inversely-related-to-the-risks-of-dental-caries-in-korean-adults
#14
In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
OBJECTIVE: This study investigated whether obesity is linked with dental caries. The present study hypothesized that obesity may influence the number or prevalence of dental caries in Korean adults. SUBJECTS AND METHODS: Data was derived from Korea National Health and Nutrition Examination Survey performed at 2008-2010. Lifestyle, sociodemographic, and biochemical variables were analyzed. Indices related with obesity, sarcopenia, and metabolic syndrome were investigated...
May 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28544047/comparison-of-oral-fluid-collection-methods-for-the-molecular-detection-of-hepatitis-b-virus
#15
Moyra Machado Portilho, Ana Carolina da Fonseca Mendonça, Vanessa Alves Marques, Leticia Cancella Nabuco, Cristiane Alves Villela-Nogueira, Claudia Ivantes, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo VIllar
BACKGROUND: This study aims to compare the efficiency of four oral fluid collection methods (Salivette, FTA Card, spitting and DNA-Sal) to detect HBV DNA by qualitative PCR. MATERIALS AND METHODS: Seventy-four individuals (32 HBV reactive and 42 with no HBV markers) donated serum and oral fluid. In-house qualitative PCR to detect HBV was used for both samples and commercial quantitative PCR for serum. RESULTS: HBV DNA was detected in all serum samples from HBV-infected individuals, and it was not detected in control group...
May 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513913/determination-of-role-of-ceruloplasmin-in-oral-potentially-malignant-disorders-and-oral-malignancy-a-cross-sectional-study
#16
P H Shah, R Venkatesh, C B More
OBJECTIVES: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker. MATERIAL AND METHODS: The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis (OSMF), oral leukoplakia (OL), nicotina stomatitis (NS), oral malignancy (OM), controls (C), and healthy controls (HC); 5 ml of blood was collected from ante cubital vein from each participant...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513096/is-the-oral-fungal-pathogen-candida-albicans-a-cariogen
#17
REVIEW
Daniel Freitas Alves Pereira, Chaminda Jayampath Seneviratne, Cristiane Yumi Koga-Ito, Lakshman Perera Samaranayake
Pathobiology of dental caries is complex. Data from recent molecular microbiologic studies have further redefined the role of the oral microbiome in the etiology of dental caries. This new information challenges the conventional view on the hegemony of classic cariogenic prokaryotes such as Streptococcus mutans in caries aetiology, and raises the intriguing possibility of the participation of the eukaryotic oral fungal pathogen Candida in the caries process. The virulence attributes of Candida species such as their acidogenicity and aciduric nature, the ability to develop profuse biofilms, ferment and assimilate dietary sugars, and produce collagenolytic proteinases are all indicative of their latent cariogenic potential...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513060/increased-oral-inflammation-leukocytes-and-leptin-and-lower-adiponectin-in-overweight-or-obesity
#18
S Thanakun, S Pornprasertsuk-Damrongsri, Y Izumi
OBJECTIVES: The association between body mass index (BMI) and oral diseases was investigated, and levels of obesity-related inflammatory mediators were evaluated. SUBJECTS AND METHODS: Participants (n = 160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponectin, leptin, and C-reactive protein (CRP) were measured. RESULTS: One hundred and thirteen (70.6%) participants had overweight or obese status (BMI ≥ 23...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28485077/ltf-and-defb1-polymorphisms-are-associated-with-susceptibility-towards-chronic-periodontitis-development
#19
Luisa Zupin, Antonietta Robino, Chiara Ottavia Navarra, Nicola Pirastu, Roberto Di Lenarda, Paolo Gasparini, Sergio Crovella, Lorenzo Bevilacqua
OBJECTIVES: Chronic periodontitis is a common pathological condition that affects the supporting tissue of the teeth, leading to progressive alveolar bone destruction and teeth loss. The disease is caused by bacteria and derives from an altered host immune and inflammatory response, also involving different factors such as the oral hygiene, smoking, genetic background etc. The innate immune response, the first line of host defense, could also play an important role in the susceptibility to chronic periodontitis...
May 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28474801/new-challenge-in-the-systemic-sclerosis-disease-management-a-call-to-action
#20
LETTER
Gaetano Isola, Giovanni Matarese
No abstract text is available yet for this article.
May 5, 2017: Oral Diseases
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