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Oral Diseases

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https://www.readbyqxmd.com/read/28644570/clinical-and-genetic-analysis-of-patients-with-cherubism
#1
R A Machado, H A R Pontes, F R Pires, H M Silveira, A Bufalino, R Carlos, F M Tuji, D B M Alves, A R Santos-Silva, M A Lopes, H M Capistrano, R D Coletta, F P Fonseca
OBJECTIVE: To describe the clinical and genetic features of patients with cherubism. MATERIAL AND METHODS: A descriptive analysis of 14 cases from 9 different families was carried out. Clinicopathological, imaging and follow-up data were retrieved from patients' medical files and correlated with the genetic profile of each patient. Genomic DNA isolated from buccal mucosa cells was subjected to direct sequencing analysis of the SH3BP2 gene. RESULTS: Females were more affected than males (8:6), and the mean age at diagnosis was 8...
June 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28644543/osteogenic-potential-of-three-different-autogenous-bone-particles-harvested-during-implant-surgery
#2
Chao Liang, Xiao Lin, Song-Ling Wang, Li-Hua Guo, Xiao-Yu Wang, Jun Li
OBJECTIVES: The aim was to compare the osteoblast activity and osteogenic potential of autogenous bone particles harvested using three different techniques, determine the most advantageous method of collecting autogenous bone particles. SUBJECTS AND METHODS: Bone particles were harvested from 20 patients during dental implant surgery using bone scraping, low-speed drilling, and bone trap filtering. After the osteoblasts were cultured, cell proliferation, migration, mineralization, transcription of osteogenesis-related genes, secretion of osteogenesis-related proteins, and osteoinductive protein content in the bone particle matrix were evaluated...
June 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28636235/stem-cell-based-tooth-and-periodontal-regeneration
#3
Lei Hu, Yi Liu, Songlin Wang
Currently regeneration of tooth and periodontal damage still remains great challenge. Stem cell-based tissue engineering raised novel therapeutic strategies for tooth and periodontal repair. Stem cells for tooth and periodontal regeneration include dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from the dental apical papilla (SCAPs), and stem cells from human exfoliated deciduous teeth (SHEDs), dental follicle stem cells (DFSCs), dental epithelial stem cells (DESCs), bone marrow mesenchymal stem cells (BMMSCs), adipose-derived stem cells (ADSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)...
June 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28632321/is-aggregatibacter-actinomycetemcomitans-the-missing-link-between-periodontitis-and-rheumatoid-arthritis
#4
David Polak
The impact of chronic conditions on the modern population is even more evident in view of a prolonged human life span. In addition, most individuals will probably simultaneously suffer from more than one chronic condition. As such, unveiling the pathogenesis of chronic diseases, as well as the causal factors that crosstalk between different conditions, is one of the greatest challenges faced by modern medicine. Two such conditions are periodontitis and rheumatoid arthritis (RA). This article is protected by copyright...
June 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28627728/can-atrophic-erosive-oral-lichen-planus-promote-cardiovascular-diseases-a-population-based-study
#5
Davide Conrotto, Roberta Barattero, Mario Carbone, Alessio Gambino, Veronica Sciannameo, Fulvio Ricceri, Federico Conrotto, Roberto Broccoletti, Paolo G Arduino
OBJECTIVES: Lichen planus has been recently associated with an increased risk of cardiovascular diseases (CVDs). The oral manifestations can be divided into white hyperkeratotic lesions (WL) and atrophic erosive lesions (RL). The aim of this report was to compare the presence of CVDs between patients affected by WL or RL, to test the hypothesis that RL are associated with an increased incidence of CVDs. SUBJECTS AND METHODS: Patients were analysed through a complete collection of all the risk factors for CVDs...
June 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28622437/detection-of-halitosis-in-breath-between-the-past-present-and-future
#6
Morad K Nakhleh, Marceau Quatredeniers, Hossam Haick
In order to develop a new generation of diagnostics for halitosis, replacing the subjective organoleptic assessment, a series of exhaled breath analyzers has been developed and assessed. All three devices rely on the assessment of exhaled Volatile Sulfuric Compounds (VSCs), which are mainly generated in and emitted from the oral cavity, contributing to the malodor. Portable, on-site and easy to use, these devices have potential for non-invasive diagnosis of halitosis. However, global assessment of exhaled VSCs alone has two main drawbacks: (1) the absence of VCSs does not rule out halitosis; (2) non-sulfuric volatile compounds that could be biomarkers of systemic diseases, found in up to 15% of halitosis cases, are neglected...
June 16, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28599095/mucojet-a-novel-oral-microjet-vaccination-system
#7
Craig S Miller, Richard N Greenberg
In a recent publication in Science Translational Medicine 9:1-9, Aran et al (2017) provide a series of elegant experiments that present an innovative noninvasive intraoral method for vaccination that uses a device termed MucoJet (Aran et al, 2017). Their findings delineate an easy to use system involving jet velocity to penetrate buccal mucosa and deliver a vaccine to underlying immune cells. This technology provides a launching pad for several potential innovations for healthcare. This article is protected by copyright...
June 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28580710/a-nomogram-for-predicting-the-risk-of-neck-node-metastasis-in-pathologically-node-negative-oral-cavity-carcinoma
#8
Sharada Sawant, Harsh Dongre, Chetan Ahire, Shilpi Sharma, Sadhana Kannan, Snehal Mahadik, Devendra Chaukar, Fatima Lukmani, Asawari Patil, Anil D'Cruz, Milind Vaidya, Prabhakar Dongre
OBJECTIVE: To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS: Surgically removed oral tumours (n=103) were analyzed for the expression of desmosomal and hemidesmosomal assembly proteins by immunohistochemistry and ultrastructural alterations by transmission electron microscopy (TEM)...
June 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28544064/obesity-is-inversely-related-to-the-risks-of-dental-caries-in-korean-adults
#9
In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
OBJECTIVE: This study investigated whether obesity is linked with dental caries. The present study hypothesized that obesity may influence the number or prevalence of dental caries in Korean adults. SUBJECTS AND METHODS: Data was derived from Korea National Health and Nutrition Examination Survey performed at 2008-2010. Lifestyle, sociodemographic, and biochemical variables were analyzed. Indices related with obesity, sarcopenia, and metabolic syndrome were investigated...
May 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28544047/comparison-of-oral-fluid-collection-methods-for-the-molecular-detection-of-hepatitis-b-virus
#10
Moyra Machado Portilho, Ana Carolina da Fonseca Mendonça, Vanessa Alves Marques, Leticia Cancella Nabuco, Cristiane Alves Villela-Nogueira, Claudia Ivantes, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo VIllar
BACKGROUND: This study aims to compare the efficiency of four oral fluid collection methods (Salivette, FTA Card, spitting and DNA-Sal) to detect HBV DNA by qualitative PCR. MATERIALS AND METHODS: Seventy-four individuals (32 HBV reactive and 42 with no HBV markers) donated serum and oral fluid. In-house qualitative PCR to detect HBV was used for both samples and commercial quantitative PCR for serum. RESULTS: HBV DNA was detected in all serum samples from HBV-infected individuals, and it was not detected in control group...
May 19, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513913/determination-of-role-of-ceruloplasmin-in-oral-potentially-malignant-disorders-and-oral-malignancy-a-cross-sectional-study
#11
Palak H Shah, Rashmi Venkatesh, Chandramani B More
OBJECTIVES: In the process of carcinogenesis, lipid peroxidation and increased oxidative stress leads to changes in certain antioxidants. The present study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker. MATERIAL AND METHODS: The total of 300 participants, were equally divided in six study groups i...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513096/is-the-oral-fungal-pathogen-candida-albicans-a-cariogen
#12
REVIEW
Daniel Freitas Alves Pereira, Chaminda Jayampath Seneviratne, Cristiane Yumi Koga-Ito, Lakshman Perera Samaranayake
Pathobiology of dental caries is complex. Data from recent molecular microbiologic studies have further redefined the role of the oral microbiome in the etiology of dental caries. This new information challenges the conventional view on the hegemony of classic cariogenic prokaryotes such as Streptococcus mutans in caries aetiology, and raises the intriguing possibility of the participation of the eukaryotic oral fungal pathogen Candida in the caries process. The virulence attributes of Candida species such as their acidogenicity and aciduric nature, the ability to develop profuse biofilms, ferment and assimilate dietary sugars, and produce collagenolytic proteinases are all indicative of their latent cariogenic potential...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28513060/increased-oral-inflammation-leukocytes-and-leptin-and-lower-adiponectin-in-overweight-or-obesity
#13
S Thanakun, S Pornprasertsuk-Damrongsri, Y Izumi
OBJECTIVES: The association between body mass index (BMI) and oral diseases was investigated, and levels of obesity-related inflammatory mediators were evaluated. SUBJECTS AND METHODS: Participants (n = 160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponectin, leptin, and C-reactive protein (CRP) were measured. RESULTS: One hundred and thirteen (70.6%) participants had overweight or obese status (BMI ≥ 23...
May 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28485077/ltf-and-defb1-polymorphisms-are-associated-with-susceptibility-towards-chronic-periodontitis-development
#14
Luisa Zupin, Antonietta Robino, Chiara Ottavia Navarra, Nicola Pirastu, Roberto Di Lenarda, Paolo Gasparini, Sergio Crovella, Lorenzo Bevilacqua
OBJECTIVES: Chronic periodontitis is a common pathological condition that affects the supporting tissue of the teeth, leading to progressive alveolar bone destruction and teeth loss. The disease is caused by bacteria and derives from an altered host immune and inflammatory response, also involving different factors such as the oral hygiene, smoking, genetic background etc. The innate immune response, the first line of host defense, could also play an important role in the susceptibility to chronic periodontitis...
May 9, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28474801/new-challenge-in-the-systemic-sclerosis-disease-management-a-call-to-action
#15
LETTER
Gaetano Isola, Giovanni Matarese
No abstract text is available yet for this article.
May 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28449413/sporadic-versus-syndromic-keratocysts-can-we-predict-treatment-outcome-a-review-of-102-cysts
#16
Dani Noy, Adi Rachmiel, Keidar Zar, Omri Emodi, Rafael M Nagler
OBJECTIVES: Keratocystic odontogenic tumor (KCOT) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment. SUBJECTS AND METHODS: We retrospectively reviewed 118 medical files of patients diagnosed with KCOT (by tissue biopsy before surgical treatment) with/without nevoid basal cell carcinoma syndrome (NBCCS) from 1995 to 2015. Data were recorded and analyzed statistically to determine the treatment-outcome correlation...
April 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28434191/the-effect-of-parotid-gland-sparing-imrt-on-salivary-composition-flow-rate-and-xerostomia-measures
#17
Thomas M Richards, Tara Hurley, Lorna Grove, Kevin J Harrington, Guy H Carpenter, Gordon B Proctor, Christopher M Nutting
OBJECTIVES: To describe parotid gland (PG) saliva organic and inorganic composition and flow rate changes, after curative intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) and analyse the relationship between PG saliva analytes and xerostomia measures. METHODS AND MATERIALS: Twenty-six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of IMRT by HNC subsite, provided longitudinal PG salivas. Salivary flow rate, subjective and objective xerostomia measures were prospectively collected and salivas tested for inorganic and organic analytes...
April 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28430393/invited-commentary-in-vivo-cutaneous-malignancy-diagnosis-using-mitochondrial-imaging
#18
Lindsay C Strowd
A recent study by Pouli et al. (2016) published in Science Translational Medicine used an elegant set of experiments to demonstrate the ability of mitochondrial monitoring to distinguish skin cancer cells from healthy tissue in vivo. This study reveals important implications regarding the future of real-time malignancy detection (Pouli 2016). Skin cancers represent the vast majority of human malignancy, with the current estimated incidence of 4.5 million cases per year in the United States alone (Centers for Disease Control 2017)...
April 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28425619/analysis-of-mutations-in-the-sos-1-gene-in-two-polish-families-with-hereditary-gingival-fibromatosis
#19
K Gawron, G Bereta, Z Nowakowska, K Łazarz-Bartyzel, J Potempa, M Chomyszyn-Gajewska, R Górska, P Plakwicz
OBJECTIVES: To establish whether two families from Malopolska and Mazovia provinces in Poland are affected by hereditary gingival fibromatosis type 1, caused by a single-cytosine insertion in exon 21 of the Son-of-Sevenless-1 gene. MATERIAL AND METHODS: Six subjects with hereditary gingival fibromatosis and five healthy subjects were enrolled in the study. Gingival biopsies were collected during gingivectomy or tooth extraction and used for histopathological evaluation...
April 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#20
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
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