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Oral Diseases

Chengjun Sun, Jicheng Sun, Minmin Tan, Bo Hu, Xiang Gao, Jinlin Song
OBJECTIVES: The aims of this systematic review were to compare the incidence and intensity of postoperative pain after single-visit root canal treatment using manual, rotary and reciprocating instruments. METHODS: An extensive literature search in PubMed, EMBASE, Cochrane Library, and Web of Science was performed to identify investigations that evaluated the effects of different instruments on post-endodontic pain. Meta-analyses and additional analyses, including subgroup and sensitivity analyses, were conducted...
March 7, 2018: Oral Diseases
Xiang-Zhen Yan, Jeroen J J P van den Beucken, Chunxue Yuan, John A Jansen, Fang Yang
OBJECTIVE: The therapeutic potential of periodontal ligament cells for periodontal regeneration gradually decreases when cultured as a monolayer in vitro. Three-dimensional cell culture models provide an alternative to traditional monolayer cell culture. This study aimed to comparatively evaluate the influence of spheroid culture on periodontal ligament cells. MATERIALS AND METHODS: Chitosan films were used to culture three-dimensional periodontal ligament cell spheroids...
March 7, 2018: Oral Diseases
Vinicius Coelho Carrard, Michelle Roxo Gonçalves, Jéssica Rodriguez Strey, Carlos Pilz, Marco Antonio Trevizani Martins, Manoela Domingues Martins, Carlos Aita Schmitz, Rafael Gustavo Dal Moro, Otávio Pereira D'Ávila, Dimitris Rucks Varvaki Rados, Erno Harzheim, Marcelo Rodrigues Gonçalves
OBJECTIVE: The diagnosis of oral lesions are often challenging for primary health care providers, which explains the high number of referrals to specialist care. This favors increases in waiting lines and delays in diagnosis, contributing to high mortality rates from oral cancer. This study aimed to summarize the experience of the EstomatoNet, a telediagnosis program catering to primary care dentists and physicians from southern Brazil. STUDY DESIGN: This exploratory study included all queries received by EstomatoNet from June/2015 to December/2016...
March 5, 2018: Oral Diseases
Kentaro Urata, Masamichi Shinoda, Daisuke Ikutame, Toshimitsu Iinuma, Koichi Iwata
OBJECTIVE: To examine whether TRPV2 contribute to the changes in intra-oral thermal and mechanical sensitivity following incision of buccal mucosa. MATERIALS AND METHODS: Buccal mucosal pain threshold were measured after the incision. Changes in the number of TRPV2-immunoreactive trigeminal ganglion neurons which innervate the whisker pad skin and buccal mucosa, changes in the number of isolectin B4-negative/positive TRPV2-immunoreactive trigeminal ganglion neurons which innervate the whisker pad skin and the buccal mucosa and the effect of peripheral TRPV2 antagonism on the pain threshold of incisional whisker pad skin and buccal mucosa were examined after these injuries...
March 5, 2018: Oral Diseases
Jairo Robledo-Sierra, Kerstin Landin-Wilhelmsen, Helena Filipsson Nyström, Robert Eggertsen, Lena Larsson, Amal Dafar, Gunnar Warfvinge, Ulf Mattsson, Mats Jontell
OBJECTIVE: To determine the levels of antithyroid antibodies and thyroid hormones in the sera of patients with oral lichen planus (OLP), and to quantify the expression of thyroid proteins in OLP lesions. SUBJECTS AND METHODS: Venous blood samples were drawn from 110 patients with OLP who had no history of thyroid disease or levothyroxine supplementation (OLP+/LT4 -). A random population sample of 657 healthy subjects was used as the control group. Two additional groups were used as comparators...
March 2, 2018: Oral Diseases
Zhenmin Liu, Xiangzhi Yong, Lanlan Jiang, Linlin Zhang, Xuefang Lin, Wei Liu, Yuanyuan Peng, Renchuan Tao
OBJECTIVES: To observe relationships between oral Candida status and salivary human beta defensin-2 and -3 (hBD-2 and hBD-3) levels in HIV/AIDS patients of Guangxi, China during the first year of antiretroviral therapy (ART) dynamically, and to understand the influence of ART on oral Candida status and salivary hBDs expressions. METHODS: A prospective self-controlled study was carried to observe the dynamic changes of CD4+ T cell counts, oral Candida carriages and salivary hBD-2,3 expressions in HIV/AIDS patients during the first year of ART...
March 2, 2018: Oral Diseases
Cai Zhang, Dan Qin, Lu Shen, Ping Ji, Jinhua Wang
OBJECTIVES: To perform a systematic review and meta-analysis on the effects of audiovisual distraction on reducing dental anxiety in children during dental treatment under local anesthesia. METHODS: The authors identified eligible reports published through August 2017 by searching PubMed, EMBASE, and Cochrane Central Register of Controlled Trials. Clinical trials that reported the effects of audiovisual distraction on children's physiological measures, self-reports and behavior rating scales during dental treatment met the minimum inclusion requirements...
March 2, 2018: Oral Diseases
Bruce J Baum
It is necessary to begin this Commentary with a very significant disclaimer. I have extensively published on and extolled the merits of using gene transfer to salivary glands as a means for turning these critically important oral tissues into valuable in vivo bioreactors to make therapeutic proteins for systemic use (e.g., Voutetakis et al, 2004; Hai et al, 2009; Perez et al, 2010). This article is protected by copyright. All rights reserved.
March 2, 2018: Oral Diseases
Diego Moura Soares, Flávia Maria de Moraes Ramos-Perez, Samuel Silva de Araújo, Priscylla Gonçalves Correia Leite de Marcelos, Andrea Dos Anjos Pontual, Danyel Elias da Cruz Perez
OBJECTIVE: To investigate the effect of sildenafil citrate on the prevention and progression of experimental periodontitis (EP) in rats. MATERIALS AND METHODS: Thirty-six male Wistar rats were randomly assigned into 2 groups: Group 1 (preventive) and Group 2 (progression). In Group 1, the animals received daily doses of sildenafil (10 mg/Kg) or vehicle for 30 days, and EP was induced on the 15th day. In Group 2, the EP was induced on the first day, and the animals received daily doses of sildenafil (10 mg/Kg) or vehicle from the 15th day...
February 26, 2018: Oral Diseases
Weiming Wang, Haofeng Xiong, Zhengmao Hu, Rongjuan Zhao, Yue Hu, Wenxin Chen, Ying Han, Liudi Yang, Xin Hu, Can Wang, Ting Mao, Kun Xia, Tong Su
OBJECTIVE: Although previous evidence indicates that CD147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD147 in oral submucous fibrosis (OSF) remain largely unknown. METHODS: In the present study, we investigated the expression of CD147 and transforming growth factor β1 (TGF-β1) in human samples of an OSF tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD147 and TGF-β1...
February 19, 2018: Oral Diseases
Aysun Coşkun Keşoğlu, Canan Bural, Gonca Erköse Genç, Zayre Erturan, Çiğdem Çınar, Fatma Oğuz, Tayfun Bilgin, Hakan Bilhan
OBJECTIVE: This clinical study investigated the association between cytokine gene polymorphism and Candida growth in DS patients. SUBJECTS AND METHODS: Saliva and blood samples of 160 complete denture wearers (80 healthy controls and 80 with DS) were collected for mycological and gene polymorphism testing, respectively. Salivary Candida growth and TNF-α, TGF-β, IL-6 and IL-10 genotypes were investigated. Data were analyzed using Student t-test, Mann-Whitney U, Chi-square analysis and Continuity (yates) correction tests (p<...
February 9, 2018: Oral Diseases
Giovanna Corrêa Denucci, Taís Fonseca Mantilla, Flávia Lucisano Botelho Amaral, Roberta Tarkany Basting, Fabiana Mantovani Gomes França, Cecilia Pedroso Turssi
OBJECTIVES: To investigate whether saliva formulations with reduced calcium (Ca) and inorganic phosphorous (Pi) concentration would affect dental erosion caused by hydrochloric acid (HCl). METHODS: Enamel and root dentine bovine slabs were embedded, polished and measured for surface Knoop microhardness (SMH). After reference areas were created, specimens were exposed to HCl solution (0.01M; pH 2; 120s) and immersed in artificial salivas (6h) containing three different Ca/Pi concentrations (n=15), which simulate serum conditions of normo-, mild- or severe hypocalcaemia...
February 8, 2018: Oral Diseases
J A Coello-Suanzes, V Rollon-Ugalde, A Castaño-Seiquer, E Lledo-Villar, J Herce-Lopez, P Infante-Cossio, A Rollon-Mayordomo
OBJECTIVE: To evaluate the effect of preventive dental management on reducing the incidence and delaying the onset of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients treated with intravenous zoledronic acid (ZA). MATERIAL AND METHODS: This single-center clinical study included 255 cancer patients monitored over a 6-year period. Patients received dental treatment prior (Group A) or after (Group B) the initiation of ZA therapy. Dental treatments performed, incidence proportion (IP) and incidence rate (IR) in both groups were analyzed using significance tests...
February 7, 2018: Oral Diseases
Christina L Maruyama, Marcus Monroe, Jason Hunt, Luke Buchmann, Olga J Baker
Mice are a widely utilized in vivo model for translational salivary gland research but must be used with caution. Specifically, mouse salivary glands are similar in many ways to human salivary glands (i.e., in terms of their anatomy, histology and physiology) and are both readily available and relatively easy and affordable to maintain. However, there are some significant differences between the two organisms, and by extension, the salivary glands derived from them that must be taken into account for translational studies...
January 30, 2018: Oral Diseases
Milena M Souza, Giovanna P Florezi, Marcello M S Nico, Fernanda de Paula, Fabiana M de Paula, Silvia V Lourenço
OBJECTIVES: Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocytes pathways induce apoptosis with an increase of Th1 and Th17 subtypes cells, triggered by the release of cytokines; This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease...
January 30, 2018: Oral Diseases
Rui Zhuang, Lijia Guo, Juan Du, Songlin Wang, Jun Li, Yi Liu
OBJECTIVE: This study includes exploring (1) the production of endogenous hydrogen sulfide (H2 S) after mucosal wound generation and (2) the role of compensating the change in H2 S level post mucosal wound generation. METHODS AND MATERIALS: A mucosal wound model was established in female C57BL/6J mice. Wound tissues were collected to exam the change in the endogenous H2 S level. To examine the effect of decreased H2 S, GYY4137 was intraperitoneally injected into mice at 50 mg/kg/day before mucosal wounding to compensate for the decreased endogenous H2 S...
January 30, 2018: Oral Diseases
Gulshan Sunavala-Dossabhoy
Tousled and its homologs are evolutionarily conserved serine/threonine kinases present in plants and animals. Human Tousled-like kinases, TLK1 and TLK2, are implicated in chromatin assembly during DNA replication, chromosome segregation during mitosis, as well as in DNA damage response and repair. They share a high degree of sequence similarity, but have few non-redundant functions. Our lab has studied TLK1, and found that it increases the resistance of cells to ionizing radiation (IR) damage through expedited double strand break (DSB) repair...
January 30, 2018: Oral Diseases
Y Hassona, N Cirillo, D Taimeh, H Al Khawaldeh, F Sawair
OBJECTIVES: To describe the natural history and factors influencing diagnostic delays among patients with autoimmune blistering diseases of the mouth. MATERIALS AND METHODS: In this cross-sectional study, 27 newly diagnosed patients were interviewed, and professional and patient delays were calculated. Disease extent and severity scores were determined using Saraswat scoring system. RESULTS: Twenty-seven patients were interviewed and examined...
January 30, 2018: Oral Diseases
Sonia Deschamps-Lenhardt, Rodrigo Martin-Cabezas, Thierry Hannedouche, Olivier Huck
A systematic review and meta-analysis was conducted to evaluate the association between periodontitis (PD) and chronic kidney disease (CKD) and to explore the potential influence of periodontal treatment in CKD patients. Databases (PubMed, Web of Science, Science direct, Cochrane Database) were screened for relevant articles, focusing on the periodontal status of patients with CKD, published until December 2017. Five-hundred fifty-three articles were identified and 37 fulfilled the inclusion criteria and were considered in this systematic review...
January 27, 2018: Oral Diseases
Andrew I Spielman, Joseph G Brand
Taste receptor cells in the tongue are epithelial in nature and turnover frequently. Taste receptor cell-associated neurons carrying bitter, sweet or sour signals never turnover and are hardwired to specific gustatory centers in the brain. How can ever-changing bitter or sweet receptors find never-changing neurons that must match the specificity of the signal? This article reviews a recent paper published in Nature (Lee et al., 2017, 548:330-333) that identified two molecules belonging to the semaphorin axon guidance family of molecules (SEMA3A and SEMA7A) that help maintain the "labelled line principle" between peripheral bitter or sweet receptors and their respective central projection area in the gustatory center...
January 24, 2018: Oral Diseases
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