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Oral Diseases

Ibrahim Oghli, Thomas List, Mike T John, Birgitta Häggman-Henrikson, Pernilla Larsson
OBJECTIVES: For Jaw Functional Limitations measured by the Jaw Functional Limitation Scale (JFLS), (i) determining prevalence in the Swedish general adult population, (ii) investigating the influence of demographic factors and self-reported dental status, and (iii) deriving normative values. METHODS: A random sample of the general adult population in Sweden was approached (response rate: 46%, N=1,372). Prevalence was determined for the JFLS summary score and individual items...
November 17, 2018: Oral Diseases
Ruoxi Dai, Otto L T Lam, Edward C M Lo, Leonard S W Li, Colman McGrath
OBJECTIVES: This study was to assess the effectiveness of a conventional oral hygiene care programme (COHCP) and an advanced oral hygiene care programme (AOHCP) on prevalence and viable counts of oral opportunistic pathogens among patients undergoing stroke rehabilitation. METHODS: A total of 94 patients were randomized to two groups. Subjects were block randomized to: either (1) COHCP: manual toothbrushing with oral hygiene instruction (OHI); or (2) AOHCP: powered toothbrushing, mouthrinsing with chlorhexidine and OHI...
November 17, 2018: Oral Diseases
García-Hernández Ana Lilia, Ángel Enrique Muñoz-Saavedra, Patricia González-Alva, Leticia Moreno-Fierros, Eduardo Fulgencio Llamosas-Hernández, Saul Ernesto Cifuentes-Mendiola, Nestor Rubio-Infante
OBJECTIVES: To evaluate the expression of proteins related to activation of the NLRP3 inflammasome in patients with chronic periodontitis (CP) and type 2 diabetes mellitus (T2D), and to determine whether the exacerbated periodontal pathological process observed in diabetic patients is related to its upregulation. MATERIALS AND METHODS: We performed an observational, analytical, cross-sectional study in three study groups: individuals systemically and orally healthy, and patients with CP with and without T2D...
November 13, 2018: Oral Diseases
Kai Zhao, Meifei Lian, Duohong Zou, Wei Huang, Wenjie Zhou, Yihan Shen, Feng Wang, Yiqun Wu
OBJECTIVES: To identify potentially pathogenic mutations for tooth agenesis by whole-exome sequencing. SUBJECTS AND METHODS: Ten Chinese families including 5 families with ectodermal dysplasia (syndromic tooth agenesis) and 5 families with selective tooth agenesis were included. Whole-exome sequencing was performing using genomic DNA. Potentially pathogenic mutations were identified after data filtering and screening. The pathogenicity of novel variants were investigated by segregation analysis, in silico analysis and functional studies...
November 12, 2018: Oral Diseases
Grigorios Thermos, Eleni-Marina Kalogirou, Konstantinos I Tosios, Alexandra Sklavounou
OBJECTIVE: Oral ulceration with bone sequestration (OUBS) describes a site-specific intraoral ulcer that covers exposed, non-vital bone in patients lacking any etiological factor known to induce osteonecrosis. We aimed to conduct a retrospective study of eight new cases of OUBS and review the literature. SUBJECTS AND METHODS: This is a retrospective study of OUBS cases, diagnosed and managed during 2007-2017. Inclusion criteria were the presence of oral ulcer with exposed non-vital bone at sites of bony prominence and the absence of any factor known to cause osteonecrosis...
November 1, 2018: Oral Diseases
Maddalena Manfredi
The development of direct oral anticoagulant drugs (DOACs) directed towards a specific target has represented a great innovation in terms of both pharmacological research and clinical practice. At present, 4 drugs (dabigatran, rivaroxaban, apixaban, ndoxaban) are available on market in different dosages and used for the treatment of non-valvular atrial fibrillation, deep vein thrombosis or pulmonary embolism (Cohen, 2015; Kirchhof, 2016; Yeh, 2014). Dabigatran (Pradaxa® ), the first DOAC approved, acts as a direct thrombin inhibitor, while rivaroxaban (Xarelto® ), apixaban (Eliquis® ) and endoxaban (Lixiana® ) are direct factor Xa inhibitors...
October 28, 2018: Oral Diseases
Avni Gupta, Rebecca B Perkins, Gezzer Ortega, Sarah Feldman, Alessandro Villa
OBJECTIVES: The incidence of Human Papillomavirus (HPV) types 16 and 18 positive oro-pharyngeal squamous cell carcinomas is increasing. Oral HPV infection is acquired through oro-genital contact. We examined the association between barrier use during oro-genital sex and oral HPV 16/18 prevalence in HPV unvaccinated individuals. METHODS: A cross-sectional analysis of individuals aged 18-59 years with a history of oro-genital sex was conducted using National Health and Nutrition Assessment Survey (NHANES) from 2009-2014...
October 26, 2018: Oral Diseases
Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Masahiro Takahashi, Haga Shugo, Takatoshi Nakawaki, Yu Hikita, Koutaro Maki, Atsushi Tajima
OBJECTIVE: Orthognathic surgery dramatically changes morphology of the maxillofacial deformity and improves the malocclusion morphologically and functionally. We investigated the influence of orthognathic surgery on genome-wide DNA methylation in saliva. METHODS: Saliva was obtained from nine patients undergoing orthognathic surgery and two healthy reference individuals before and 3 months after orthognathic surgery. Genome-wide DNA methylation profiling of saliva (341,482 CpG dinucleotides) was conducted using Infinium HumanMethylation450 Beadchips...
October 26, 2018: Oral Diseases
Marcelo C Marinho, Ana Beatriz Furlanetto Pacheco, Giovani Carlo Verissimo da Costa, Nina Daddario Ortiz, Lenita Zajdenverg, Carmelo Sansone
OBJECTIVE: The aim of this study was to investigate the proteome of the gingival crevicular fluid comparing the relative abundance of proteins from type 2 Diabetes Mellitus (2DM) individuals and chronic periodontitis (CP) affected sites, subjects affected by both conditions and healthy individuals. MATERIAL AND METHODS: Twenty individuals were equally allocated in 4 groups, 2DM with CP, 2DM periodontally healthy, CP without 2DM and periodontally healthy without 2DM...
October 25, 2018: Oral Diseases
Sérgio Antonucci Amaral, Thaís Santos Fontes Pereira, João Artur Ricieri Brito, Sheila Cavalca Cortelli, José Roberto Cortelli, Ricardo Santigo Gomez, Fernando Oliveira Costa, Luís Otávio Miranda Cota
OBJECTIVES: MicroRNAs (miRNAs) may play an important role in inflammatory response. However, the involvement of miRNAs in the pathogenesis of periodontitis is unclear. The present study aimed to compare the miRNA expression profiles in individuals with chronic (CP) or aggressive (AP) periodontitis. MATERIALS AND METHODS: Eighteen non-smoker individuals (CP = 9 and AP = 9) without any history of systemic diseases or previous periodontal therapies were selected at the Clinics of Periodontology from the Federal University of Minas Gerais...
October 23, 2018: Oral Diseases
Wan Maria Nabillah Ghani, Ishak Abdul Razak, Jennifer Geraldine Doss, Yi-Hsin Yang, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Mannil Thomas Abraham, Wan Mahadzir Wan Mustafa, Tay Keng Kiong, Rosnah Binti Zain
OBJECTIVE: To elucidate ethnic variations in the practice of oral cancer risk habits in a selected Malaysian population. METHODS: This retrospective case-control study involves 790 cases of cancers of the oral cavity and 450 controls presenting with non-malignant oral diseases, recruited from seven hospital-based centers nationwide. Data on risk habits (smoking, drinking, chewing) were obtained using a structured questionnaire via face-to-face interviews. Multiple logistic regression was used to determine association between risk habits and oral cancer risk; Chi-square test was used to assess association between risk habits and ethnicity...
October 23, 2018: Oral Diseases
Francisco Ivison Rodrigues Limeira, Monica Yamauti, Allyson Nogueira Moreira, Tuélita Marques Galdino, Cláudia Silami de Magalhães, Lucas Guimarães Abreu
OBJECTIVE: To evaluate studies assessing the prevalence of dental caries and developmental defects of enamel (DDE) in individuals with chronic kidney disease (CKD) in comparison with individuals without CKD. MATERIALS AND METHODS: Electronic searches were performed in Pubmed, Web of Science, Scopus, Medline via Ovid and ProQuest databases from their inception date until February 2018. Two review authors independently selected the studies, extracted data, and assessed the methodological quality...
October 18, 2018: Oral Diseases
Suad Aljohani, Matthias Troeltzsch, Sigurd Hafner, Gabriele Kaeppler, Gerson Mast, Sven Otto
PURPOSE: The management of maxillary medication-related osteonecrosis of the jaw (MRONJ) is challenging. Therefore, identifying the proper treatment is important. This study aimed to evaluate the surgical treatment of maxillary MRONJ using single-layer closure with mucoperiosteal flap and double-layer closure with buccal fat pad flap (BFPF) and mucoperiosteal flap and to find the outcomes after rehabilitation with obturators. METHODS: A retrospective analysis was conducted and included all surgically treated and followed-up maxillary MRONJ cases in a single center...
October 16, 2018: Oral Diseases
Meri Sieviläinen, Rabeia Almahmoudi, Ahmed Al-Samadi, Tuula Salo, Matti Pirinen, Alhadi Almangush
BACKGROUND: Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC. MATERIALS: A systematic search was conducted in Ovid Medline, Scopus and Cochrane libraries and all studies that evaluated the prognostic significance of immune checkpoints in OSCC were systematically retrieved...
October 13, 2018: Oral Diseases
Ronell Bologna-Molina, Ikuko Ogawa, Adalberto Mosqueda-Taylor, Takashi Takata, Celeste Sánchez-Romero, Mariana Villarroel-Dorrego, Yasunori Takeda, Toshinari Mikami
OBJECTIVE: this study aimed to assess the frequency of KRAS mutation and its association with the presence of the MAPK / ERK signaling pathway proteins in adenomatoid odontogenic tumors. STUDY DESIGN: Paraffin-embedded tissue samples from 9 cases of adenomatoid odontogenic tumor were used. Genomic DNA was extracted from each sample; in one case: genetic mutations in 50 cancer-associated genes were examined by next-generation sequencing. Hotspot mutations in the RAS family were analyzed by luminex assay using the remaining 8 cases...
October 8, 2018: Oral Diseases
Xiuqing Wang, Yufei Wang, Kun Wang, Qian Ren, Haoran Li, Sainan Zheng, Yumei Niu, Xuedong Zhou, Wei Li, Linglin Zhang
OBJECTIVES: Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS: We designed peptides TDH19, TNH19 and TVH19, and selected one through comparing their minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) against Streptococcus mutans and their reaction on mineralization...
October 6, 2018: Oral Diseases
Li-Na Zhou, Chun-Sheng Bi, Li-Na Gao, Ying An, Fang Chen, Fa-Ming Chen
OBJECTIVE: Although accumulating evidence indicates that macrophages are central players in the destructive and reparative phases of periodontal disease, their polarization states at different stages of periodontal inflammation remain unclear. METHODS: We collected gingival biopsies from patients with chronic periodontitis (P group), gingivitis (G group), or periodontally healthy individuals (H group). Polarized macrophages were identified through immunofluorescence...
October 4, 2018: Oral Diseases
Enrique A Castellón
No abstract text is available yet for this article.
October 3, 2018: Oral Diseases
Thiago Cruvinel, Patricia E Ayala Aguirre, Matheus Lotto, Thaís Marchini Oliveira, Daniela Rios, Agnes F Pereira Cruvinel
OBJECTIVE: To determine the differences between the levels of interest of South American Google users on information related to dental caries and toothache over time. MATERIALS AND METHODS: The monthly variation of Relative Search Volume (RSV) for both queries was obtained in Google Trends between 2004 and 2017. The association between RSVs, Internet penetration, and disability-adjusted life-years (DALYs) for dental caries in permanent teeth were tested by distinct regression models...
October 1, 2018: Oral Diseases
Nirav R Shah, Braxton D Noll, Farah K B Mougeot, Ricardo J Padilla, Mike T Brennan, Jean-Luc C Mougeot
OBJECTIVE: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease affecting exocrine glands, thereby causing dry mouth and eyes (sicca). Our objective was to determine the expression of pSS pathogenic biomarker MMP9 and its putative transcription factors ETS1 and LEF1, in labial salivary glands of pSS patients. METHODS: Sicca patients were assigned to three groups based on focus score (FS): non-pSS sicca (i.e., GR1 [FS=0] and GR2 [0<FS<1]), and pSS (i...
October 1, 2018: Oral Diseases
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