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Oral Diseases

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https://www.readbyqxmd.com/read/29791070/role-of-oral-examination-in-newly-diagnosed-multiple-myeloma-patients-a-safe-and-simple-way-to-detect-light-chain-amyloidosis
#1
Merav Leiba, Suha Jarjoura, Waseem Abboud, Arnon Nagler, Ran Yahalom, Adrian Duek, Noam Yarom
OBJECTIVE: Up to 30% of multiple myeloma (MM) patients have subclinical amyloid deposits. These patients are under-recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The objective of the present study was to assess the prevalence and characteristics at presentation of oral amyloidosis in a large cohort of MM patients. METHODS: The prevalence and characteristics of oral amyloidosis in a large cohort of MM patients who were referred for oral evaluation before and during bisphosphonate therapy were assessed, retrospectively...
May 23, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29787635/abnormal-bone-remodeling-activity-of-dental-follicle-cells-from-a-cleidocranial-dysplasia-patient
#2
Yang Liu, Xianli Zhang, Xiangyu Sun, Xiaozhe Wang, Chenying Zhang, Shuguo Zheng
OBJECTIVES: To explore the role of dental follicle cells (DFCs) with a novel cleidocranial dysplasia (CCD) causative gene RUNX2 mutation (DFCsRUNX 2+/m ) in delayed permanent tooth eruption. MATERIALS AND METHODS: A CCD patient with typical clinical features was involved in this study. DFCsRUNX 2+/m were cultured and DNA was extracted for RUNX2 mutation screening. Measurements of cell proliferation, alkaline phosphatase (ALP) activity, alizarin red staining and osteoblast-specific genes expression were performed to assess osteogenesis of DFCsRUNX 2+/m ...
May 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29787631/tooth-loss-and-dental-implant-outcomes-where-is-dentistry-going-a-survey-by-sidp-the-italian-society-of-periodontology-and-implantology
#3
LETTER
Francesco Cairo, Luca Landi, Claudio Gatti, Giulio Rasperini, Mario Aimetti
Recently, the Italian Society of Periodontology and Implantology (SIdP) committed an extensive survey to evaluate tooth loss and actual success of dental implants in the population. We would share the main outcomes with the present letter. This article is protected by copyright. All rights reserved.
May 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29786923/biodiversity-of-the-human-oral-mycobiome-in-health-and-disease
#4
H M H N Bandara, C P Panduwawala, L P Samaranayake
The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years...
May 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29782691/mass-spectrometry-in-the-palm-of-your-hand-future-applications-of-in-vivo-tissue-analysis
#5
Simon A Fox, Camile S Farah
Assessment and diagnosis of oral mucosal disorders continues to present clinical challenges with conventional methodologies being time consuming and hampered by subjectivity. These considerations also apply to surgical excision of malignant and potentially malignant lesions where accurate assessment of margins is critical to patient outcomes. These clinical needs are driving the development of new technologies which can enable rapid diagnosis based upon characteristic molecular profiles identified through clinical science...
May 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29782688/oral-yeast-colonization-in-patients-with-primary-and-secondary-sj%C3%A3-gren-s-syndrome
#6
Clarissa Castro Galvão Medeiros, Luiz Gustavo Dos Anjos Borges, Karen Cherubini, Fernanda Gonçalves Salum, Renata Medina da Silva, Maria Antonia Zancanaro de Figueiredo
OBJECTIVE: The study aimed to investigate the pattern of oral yeast colonization of Sjögren's syndrome patients and its correlation to salivary flow rates, age and time of the disease progression. MATERIALS AND METHODS: Saliva and swab specimens were obtained from 45 patients (primary Sjögren's syndrome= 15/ secondary Sjögren's syndrome= 15/ healthy controls= 15). Yeast species were identified using culture method through chromogenic medium followed by polymerase chain reaction and Sanger sequencing...
May 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29774977/a-novel-4q25-microdeletion-encompassing-pitx2-associated-with-rieger-syndrome
#7
Yi Yang, Xin Wang, Yuming Zhao, Man Qin
OBJECTIVE: Rieger syndrome (RS) is a genetic disorder characterized by abnormal development of the eyes, teeth, and umbilicus, and the paired like homeodomain 2 (PITX2) gene is often implicated in its pathogenesis. The present study aimed to identify the underlying genetic defect in a Chinese patient with RS. SUBJECTS AND METHODS: DNA samples were screened for PITX2 gene mutations and copy number variations (CNVs) using Sanger sequencing and quantitative genomic PCR analysis (qPCR)...
May 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29774969/combined-effect-of-parathyroid-hormone-and-strontium-ranelate-on-bone-healing-in-ovariectomized-rats
#8
Funda Göker, Selim Ersanlı, Volkan Arısan, Erdal Cevher, Emine Elif Güzel, Halim İşsever, Beyhan Ömer, Gülay Durmuş Altun, Deniz Morina, Tuğba Ekiz Yılmaz, Elmire Dervişoğlu, Massimo Del Fabbro
OBJECTIVE: Parathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical sized defects of ovariectomized rats. MATERIALS AND METHODS: PTH- and/or SR-containing poloxamer implant tablets with/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats...
May 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29766617/gingival-tissue-reaction-to-direct-adhesive-restoration-a-preliminary-study
#9
Carlo Bertoldi, Davide Zaffe, Luigi Generali, Andrea Lucchi, Pierpaolo Cortellini, Emanuela Monari
INTRODUCTION: It is debated if composite resin marginal/submarginal direct restoration can be usefully performed without inflammatory consequences. This histological study is the first human analysis aimed to compare, in the same tooth, the gingival tissue close to composite resin restorations with gingival tissue close to hard tissue. METHODS: Eight healthy patients with almost a residual strategic tooth needing endodontic therapy, and post-and-core restoration, then indirect prosthetic restoration, were selected...
May 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29766614/non-inferiority-trials-in-oral-medicine
#10
Jose Leopoldo Ferreira Antunes, Carina Domaneschi, Celso Augusto Lemos
More than a century ago, Greenwood and Yule (1915) published a seminal paper explaining the epidemiological assessment of vaccine effectiveness. To illustrate their argument, they compared the incidence of typhoid fever among vaccinated and non-vaccinated British troops stationed in France and Belgium, based on the previously available information.Little consideration was given to issues that we would care so much afterward; nothing was said about why and how some were, and others were not vaccinated. This article is protected by copyright...
May 15, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29761905/stress-related-salivary-proteins-affect-the-production-of-volatile-sulfur-compounds-by-oral-bacteria
#11
Patricia Oliveira de Lima, Bruno Dias Nani, Barbara Almeida, Fernanda Klein Marcondes, Francisco Carlos Groppo, Antonio Bento Alves de Moraes, Michelle Franz-Montan, Karina Cogo-Müller
OBJECTIVE: To determine whether stress-related substances and sex hormones influence the growth and in vitro production of volatile sulfur compounds (VSCs) by Solobacterium moorei and Fusobacterium nucleatum. MATERIALS AND METHODS: Bacteria growth and VSCs production were evaluated in the presence of alpha-amylase, beta-defensin-2, mucin, estradiol, and progesterone. Growth was evaluated by colony counting, and the production of the VSCs hydrogen sulfide (H2 S) and methyl mercaptan (CH3 SH) was measured using the Oral Chroma™ instrument...
May 15, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29761881/expression-of-stem-cell-markers-nanog-and-nestin-in-lip-squamous-cell-carcinoma-and-actinic-cheilitis
#12
Fernanda M Scotti, Verônica C Mitt, Daniella S C Vieira, Michelle T Biz, Renata G Castro, Filipe Modolo
Cancer stem cells ( CSC ) proteins have been observed in several lesions and are associated with tumor beginning, evolution, and resistance to treatment. OBJECTIVES: to investigate the presence of NANOG, NESTIN, and β-tubulin in lip squamous cell carcinoma (LSCC), actinic cheilitis (AC), and normal epithelium (NE). MATERIALS AND METHODS: thirty cases of LSCC, thirty cases of AC (both analyzed according to the WHO classification and AC according to the binary classification), and twenty cases of NE were submitted to an immunohistochemical study...
May 15, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29757485/tobacco-smoking-decreases-clinical-symptoms-of-gingivitis-in-patients-with-type-1-diabetes-a-cross-sectional-study
#13
Mateusz Tarnowski, Anna Duda-Sobczak, Jakub Lipski, Dorota Zozulinska-Ziolkiewicz, Marzena Wyganowska-Swiatkowska
OBJECTIVE: Periodontal disease may develop on the background of microvascular complications of diabetes. However, some modifying factors, such as tobacco smoking should be taken into consideration when assessing risk of development of chronic complications. The aim of the study was the clinical assessment of the periodontal status in patients with type 1 diabetes according to tobacco smoking. SUBJECTS AND METHODS: 362 subjects aged 29 (IQR 22-35) years, type 1 diabetes duration 12 (8-18) years, hemoglobin A1c, HbA1c 8...
May 14, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29757479/image-cytometry-dna-ploidy-analysis-correlation-between-two-semi-automated-methods
#14
Janaina Salomon Ghizoni, Marcelo Sperandio, Claire Lock, Edward W Odell
BACKGROUND AND OBJECTIVES: Quantitation of cell DNA content, DNA ploidy, has been established as a research and prognostic technique for decades. A variety of instruments have been used despite only a few commercially available systems having established quality assurance and published outcome data. The aim of this study was to compare two automated systems. METHODS: Nuclear monolayers were obtained from 112 oral biopsies by enzyme digestion and Feulgen staining...
May 14, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29750853/depth-of-invasion-on-pathological-outcomes-in-clinical-low-stage-oral-tongue-cancer-patients
#15
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29750386/saliva-in-the-omics-era-a-promising-tool-in-paediatrics
#16
Eftychia Pappa, Eleni Kousvelari, Heleni Vastardis
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its non-invasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29738106/rate-of-malignant-transformation-of-oral-lichen-planus-a-systematic-review
#17
REVIEW
Michele Giuliani, Giuseppe Troiano, Massimo Cordaro, Massimo Corsalini, Gioele Gioco, Lorenzo Lo Muzio, Pamela Pignatelli, Carlo Lajolo
OBJECTIVE: The aim of this study is to systematically review the literature to determine: 1) the malignant transformation rate (TR) of Oral Lichen Planus (OLP) and its risk factors; 2) whether or not Oral Lichenoid Lesions (OLL) have a different malignant TR. MATERIALS AND METHODS: PubMed, Scopus and Web of Science were used as search engines: only observational, full-length, English language studies were investigated. PRISMA protocol was used to evaluate and present results...
May 8, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29729210/enhanced-car-t-cell-therapy-a-novel-approach-for-head-and-neck-cancers
#18
Songlin Wang, Zhao Zhu
Head and neck cancer that presents in locally advanced stages often results in a bad prognosis with an increased recurrence rate even after curative resections. Radiation therapy is then applied, with multiple side effects, as adjuvant regional therapy. Because of the high rate of recurrence and mortality, new therapies are needed for patients suffering from head and neck malignant tumors.CAR (chimeric antigen receptor) T cell therapy, which was first devised about 25 years ago, causes the killing or apoptosis of target tumor cells through inducing the secretion of cytokines and granzymes by T cells (Cheadle et al...
May 5, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29729070/effect-of-the-three-enterococcus-faecalis-strains-on-apoptosis-in-mc3t3-cells
#19
Yang Li, Zhongchun Tong, Junqi Ling
OBJECTIVE: Osteoblast apoptosis is critical for the development and repairing of bone destruction in persistent apical periodontitis (PAP). Enterococcus faecalis is considered as a frequently isolated pathogen of PAP. This study aimed to explore the effect of E. faecalis on apoptosis in osteoblastic MC3T3-E1 cells via an in vitro model. MATERIALS AND METHODS: MC3T3 cells were incubated with live clinically isolated strains of E. faecalis at a multiplicity of infection (MOI) of 1000:1 for 2 h...
May 4, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29706018/hpv-prevalence-in-a-mid-european-oral-squamous-cell-cancer-population-a-cohort-study
#20
Daniel Dalla Torre, Doris Burtscher, Elisabeth Soelder, Vincent Offermanns, Michael Rasse, Wolfgang Puelacher
OBJECTIVES: HPV infection has been investigated intensively regarding oropharyngeal carcinoma. However, there is still lack of knowledge about the impact of oral HPV infections concerning oral squamous cell carcinoma. The present study investigates the prevalence of oral HPV infection in such patients, identifying possible differences between HPV+ and HPV- patients. SUBJECTS AND METHODS: 106 consequent patients were investigated. After completion of a study questionnaire regarding risk factors, a brush smear sample was taken in each subject to identify the individual oral HPV status (overall/low risk/high risk)...
April 29, 2018: Oral Diseases
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