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Oral Diseases

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https://www.readbyqxmd.com/read/29356306/evidence-of-interaction-between-genes-in-the-folate-homocysteine-metabolic-pathway-in-controlling-risk-of-nonsyndromic-oral-cleft
#1
Ping Wang, Tao Wu, Holger Schwender, Hong Wang, Bing Shi, Zhuqing Wang, Yuan Yuan, Dongjing Liu, Mengying Wang, Jing Li, Zhibo Zhou, Hongping Zhu, Terri H Beaty
OBJECTIVE: Little consistent evidence is available for the association between the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and any of the individual genes in the folate/homocysteine metabolic pathway. We investigated the genes in the folate pathway to further clarify its potential influence on the risk of NSCL/P considering gene-gene (G×G) interaction. SUBJECTS AND METHODS: We selected markers in 18 genes from the pathway and applied the Cordell's method to test for G×G interaction using 1,908 NSCL/P case-parent trios ascertained in an international consortium where a genome-wide association study (GWAS) of oral clefts was conducted...
January 22, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29356251/dedifferentiated-fat-dfat-cells-a-cell-source-for-oral-and-maxillofacial-tissue-engineering
#2
Naotaka Kishimoto, Yoshitomo Honda, Yoshihiro Momota, Simon D Tran
Tissue engineering is a promising method for the regeneration of oral and maxillofacial tissues. Proper selection of a cell source is important for the desired application. This review describes the discovery and usefulness of Dedifferentiated Fat (DFAT) cells as a cell source for tissue engineering. DFAT cells are a highly homogeneous cell population (high purity), highly proliferative, and possess a multilineage potential for differentiation into various cell types under proper in vitro inducing conditions and in vivo...
January 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29337414/proliferative-leukoplakia-proposed-new-clinical-diagnostic-criteria
#3
Alessandro Villa, Reshma S Menon, Alexander R Kerr, Fabio De Abreu Alves, Andres Guollo, David Ojeda, Sook B Woo
OBJECTIVE: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathologic standpoint and suggest an updated classification. SUBJECTS AND METHODS: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathologic features, and malignant transformation (MT). RESULTS: There were 42 patients (median age: 69 years [range:36-88]; 35 females)...
January 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29316063/bilirubin-reversibly-affects-cell-death-and-odontogenic-capacity-in-shed
#4
Haruyoshi Yamaza, Erika Tomoda, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza
OBJECTIVE: Hyperbilirubinemia in patients with biliary atresia causes deciduous tooth injuries such as green pigmentation and dentin hypoplasia. In patients with biliary atresia who received liver transplantation, tooth structure appears to be recovered radiographically. Nevertheless, little is known about cellular mechanisms underlying bilirubin-induced damage and suppression of deciduous tooth formation. In this study, we examined the effects of bilirubin in stem cells from human exfoliated deciduous teeth (SHED) in vitro...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29316040/herpesviruses-viral-loads-and-levels-of-proinflammatory-cytokines-in-apical-periodontitis
#5
Aleksandar Jakovljevic, Aleksandra Knezevic, Nadja Nikolić, Ivan Soldatović, Tanja Jovanovic, Jelena Milasin, Miroslav Andric
OBJECTIVES: This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β, and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines . MATERIALS AND METHODS: 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29316035/transcription-factor-eb-tfeb-influences-invasion-and-migration-in-oral-squamous-cell-carcinomas
#6
Hiroshi Sakamoto, Kentaro Yamashita, Kuniaki Okamoto, Tomoko Kadowaki, Eiko Sakai, Masahiro Umeda, Takayuki Tsukuba
OBJECTIVE: Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and plays an important role in various cancers. However, the function of TFEB in oral squamous cell carcinomas has not been examined. The aim of this study was to elucidate the role of TFEB in oral squamous cell carcinomas. MATERIALS AND METHODS: Expression levels of TFEB were examined in six different human oral squamous carcinoma cells: HSC2, HSC3, HSC4, SAS, OSC20, and SCC25...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29316023/sj%C3%A3-gren-s-syndrome-x-chromosome-dose-effect-an-epigenetic-perspective
#7
REVIEW
Jean-Luc C Mougeot, Braxton Noll, Farah K Bahrani Mougeot
Sjögren's syndrome (SS) is a chronic autoimmune disease affecting exocrine glands leading to mouth and eyes dryness. The extent to which epigenetic DNA methylation changes are responsible for an X-chromosome dose effect has yet to be determined. Our objectives were to (i) describe how epigenetic DNA methylation changes could explain an X-chromosome dose effect in SS for women with normal 46,XX genotype and (ii) determine the relevant relationships to this dose effect, between X-linked genes, genes controlling X-chromosome inactivation (XCI) and genes encoding associated transcription factors, all of which are differentially expressed and/or differentially methylated in the salivary glands of SS patients...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29316022/association-between-buccal-mucosa-ridging-and-oral-or-occlusal-status-among-older-people
#8
Koji Morita, Takahiro Mori, Mariko Maruyama, Aya Hiraoka, Chiaki Higa, Azusa Kuroki, Mitsuyoshi Yoshida, Kazuhiro Tsuga
OBJECTIVES: The present study aimed to evaluate the association between buccal mucosa ridging and oral or occlusal statuses among older people. SUBJECTS AND METHODS: This cross-sectional study examined 262 independent older people (mean age, 74.2 ± 5.9 years) who participated in the Kyoto Elderly Physical Fitness Measurement Research Project. The predictor variables were oral statuses (number of present teeth and torus palatinus, torus mandibularis, temporomandibular joint noise, clenching, or grinding) and oral functions (occlusal pressure, cheek pressure, oral diadochokinesis, and tongue pressure)...
January 9, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29297959/p2y2-r-deletion-ameliorates-sialadenitis-in-il-14%C3%AE-transgenic-mice
#9
Lucas T Woods, Jean M Camden, Mahmoud G Khalafalla, Michael J Petris, Laurie Erb, Julian L Ambrus, Gary A Weisman
OBJECTIVE: Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and hyposalivation. The P2Y2 receptor (P2Y2 R) for extracellular ATP and UTP is upregulated during salivary gland inflammation (i.e., sialadenitis) where it regulates numerous inflammatory responses. The present study investigated the role of P2Y2 Rs in autoimmune sialadenitis in the IL-14αTG mouse model of Sjögren's syndrome...
January 3, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29297958/randomized-placebo-controlled-double-blind-trial-of-clobetasol-propionate-0-05-in-the-treatment-of-oral-lichen-planus
#10
P G Arduino, M G Campolongo, V Sciannameo, D Conrotto, A Gambino, M Cabras, F Ricceri, S Carossa, R Broccoletti, M Carbone
OBJECTIVE: To perform a randomized, placebo-controlled, double-blind study, with a follow-up period of 6 months, for the use of topical clobetasol in cases of symptomatic oral lichen planus (OLP). SUBJECTS AND METHODS: Thirty-two participants were analyzed, with the aims of: (I) to compare the usefulness of topically applied clobetasol propionate 0.05% (mixed with 4% hydroxyethyl cellulose gel) and 4% hydroxyethyl cellulose gel alone (considered as placebo) in the management of OLP; (II) to describe which of them is quicker in decreasing signs and reported symptoms, and (III) which is able to give the proper longer remission in the follow-up...
January 3, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29292572/chk2-deficiency-alleviates-irradiation-induced-taste-dysfunction-by-inhibiting-p53-dependent-apoptosis
#11
Zhiyao Yuan, Junchi Ma, Xin Meng, Ning Chen, Ming Shen
OBJECTIVE: Taste dysfunction is one of the most common complications following radiotherapy, which leads to decreased appetite and life quality of patients suffering from head and neck cancer. The aim of this study was to investigate the role of Checkpoint kinase2 (Chk2) deficiency in irradiation-induced taste dysfunction. MATERIALS AND METHODS: Alterations in oxidative stress, DNA damage and potential signaling pathway were compared between Chk2-deficient (Chk2-/- ) mice and their wild-type (WT) littermates pre-irradiation, and 7 and 30 days post-irradiation by biochemistry and immunohistochemistry...
January 2, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29284200/betel-and-tobacco-chewing-habit-and-its-relation-to-risk-factors-for-periodontal-disease
#12
Maria Laura Giovannoni, Iván Valdivia-Gandur, Vicente Lozano de Luaces, Héctor Varela Véliz, Yamadala Balasubbaiah, Eduardo Chimenos-Küstner
OBJECTIVES: To comparatively assess periodontal status in patients who chew different products and patients who do not have this habit and to assess how this practice interacts with predisposing factors and risk indicators of disease. METHODS: Patients included in the dental care carried out in a rural community in India were considered for a cross-sectional study. The Simplified Oral Hygiene Index and the Community Periodontal Index (CPI) were assessed. Furthermore, a validated survey with items concerning chewing habits was administered...
December 28, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29250913/brain-responses-to-stimuli-mimicking-dental-treatment-among-non-phobic-individuals-a-meta-analysis
#13
REVIEW
Andy Wai Kan Yeung, Tazuko K Goto, W Keung Leung
Numerous neuroimaging studies have attempted to identify how the brain responds to stimuli mimicking dental treatment in normal non-phobic individuals. However, results were sometimes inconsistent due to small sample sizes and methodological variations. This meta-analysis employs standardized procedures to summarize data from previous studies to identify brain regions that were consistently activated across studies, elicited by stimuli such as pictures, sounds, or audiovisual footage mimicking those encountered during dental treatments...
December 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29243374/molecular-classification-of-autofluorescence-excision-margins-in-oral-potentially-malignant-disorders
#14
Camile S Farah, Farzaneh Kordbacheh, Keziah John, Nigel Bennett, Simon A Fox
OBJECTIVE: To define molecular differences between autofluorescence and white light defined excision margins in oral potentially malignant disorders (OPMD) using transcriptome expression profiles. MATERIALS AND METHODS: Excisional biopsy specimens were taken from 11 patients at three different sites for each lesion: centre, white light margin, and autofluorescence margin. The lesions were diagnosed histopathologically as oral epithelial dysplasia, oral lichenoid dysplasia, oral lichen planus or other...
December 14, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29230915/periapical-infection-may-affect-birth-outcomes-via-systemic-inflammation
#15
U Harjunmaa, R Doyle, J Järnstedt, S Kamiza, J M Jorgensen, C P Stewart, L Shaw, L Hallamaa, U Ashorn, N Klein, K G Dewey, K Maleta, P Ashorn
OBJECTIVES: Maternal dental periapical infections are associated with preterm birth and intrauterine growth restriction. This study investigates if the association is mediated through bacterial spread from periapical lesions to placenta (direct pathway) or systemic inflammatory reaction (indirect pathway). MATERIALS AND METHODS: We compared birth outcomes in Malawian mothers with and without periapical infection. As markers of a direct pathway, we identified placental bacteria using a 16S rDNA approach, and assessed histological evidence of inflammation in the placenta and amniotic membranes...
December 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29230909/histatins-wound-healing-and-cell-migration
#16
Pedro Torres, Martín Castro, Montserrat Reyes, Vicente A Torres
Wounds in the oral mucosa heal faster and more efficiently than those in the skin, although the mechanisms underlying these differences are not completely clear. In the last 10 years, a group of salivary peptides, the histatins, have gained attention on behalf of their ability to improve several phases of the wound healing process. In addition to their roles as antimicrobial agents and in enamel maintenance, histatins elicit other biological effects, namely by promoting the migration of different cell types contained in the oral mucosa and in non-oral tissues...
December 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29224195/prevalence-of-soft-tissue-calcifications-in-the-maxillofacial-region-detected-by-cone-beam-ct
#17
Eucaé Miranda Missias, Eduarda Helena Leandro Nascimento, Maria Luiza Dos Anjos Pontual, Andréa Dos Anjos Pontual, Deborah Queiroz Freitas, Danyel Elias da Cruz Perez, Flávia Maria de Moraes Ramos-Perez
OBJECTIVE: To determine the prevalence of soft tissue calcifications in cone beam computed tomography (CBCT) scans with different fields of view (FOV), and to assess its relation with the clinical relevance of the CBCT findings. MATERIAL AND METHODS: One thousand CBCT scans were grouped according to FOV's size and region scanned (MX-FOV, maxilla; MD-FOV, mandible; and MM-FOV, maxilla/mandible) and evaluated for the presence of soft tissue calcifications. Laterality and length of the elongated styloid processes (ESP) were also assessed...
December 10, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29215771/p16-positivity-and-regression-grade-predict-survival-after-neoadjuvant-radiotherapy-of-oscc
#18
Christina Eder-Czembirek, Irene Sulzbacher, Thorsten Fuereder, Edgar Selzer
OBJECTIVES: Survival after preoperative radiotherapy in locally advanced head and neck squamous cell cancer is associated with pathological response. The prognostic importance of p16 expression in these patients has not been established yet. MATERIALS AND METHODS: Ninety-seven oral squamous cell carcinoma patients, treated preoperatively with radiotherapy in combination with chemotherapy or cetxuximab, were included in this retrospective analysis. Survival rates were estimated by the Kaplan-Meyer method...
December 7, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29197149/cd29-is-highly-expressed-on-epithelial-myoepithelial-and-mesenchymal-stromal-cells-of-human-salivary-glands
#19
Padma Priya Togarrati, Nuntana Dinglasan, Shivani Desai, William R Ryan, Marcus O Muench
OBJECTIVE: The phenotype of the cells present in the ductal region of salivary glands have been well characterized. However, it is imperative to identify novel biomarkers that can identify different cell types present in other glandular components for the development of therapeutic strategies and diagnostics of salivary gland disorders and malignancies. Our study aimed at the characterization of the expression and distribution of various cell surface markers, especially with a focus on CD29 in human fetal as well as adult glands...
December 2, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29197137/immunohistopathological-characterization-and-the-impact-of-topical-immunomodulatory-therapy-in-oral-chronic-gvhd-a-pilot-study
#20
Ana Carolina F Motta, Qian Zhan, Allison Larson, Mark Lerman, Sook-Bin Woo, Robert J Soiffer, George F Murphy, Nathaniel S Treister
OBJECTIVE: To characterize the immunohistopathologic features of oral chronic graft-versus-host disease (cGVHD), and the impact of topical immunomodulatory therapy on the infiltrating cells. MATERIAL AND METHODS: Paired oral cGVHD biopsies obtained before (n=12) and one month after treatment (n=12) with topical dexamethasone (n=8) or tacrolimus (n=4) were characterized by immunohistochemistry using a panel of CD1a, CD3, CD4, CD8, CD20, CD31, CD62E, CD103, CD163, c-kit and FoxP3...
December 2, 2017: Oral Diseases
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