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Oral Diseases

Emanuely da Silva Chrun, Filipe Modolo, Daniella Serafim Couto Vieira, Álvaro Luiz Socorro Borges, Renata Goulart Castro, Filipe Ivan Daniel
BACKGROUND: Acetylation/deacetylation are the most studied covalent histone modifications resulting in transcriptional regulation with histone deacetylases (HDAC) and histone acetyltransferases (HAT) as the main associated enzymes. These enzymes overexpression induces abnormal transcription of key genes that regulate important cellular functions, such as proliferation, cell cycle regulation, and apoptosis. Thus, the expression of different HATs and HDACs has been evaluated in various cancers...
January 20, 2017: Oral Diseases
Ahmed S Sultan, Alessandro Villa, Arturo P Saavedra, Nathaniel S Treister, Sook-Bin Woo
OBJECTIVES: Few studies have compared oral mucous membrane pemphigoid (MMP) and pemphigus vulgaris (PV). Descriptive analysis of oral features, extent of extra-oral involvement and management outcomes were performed. SUBJECTS AND METHODS: Patients with PV and MMP, the latter with exclusive oral involvement at first presentation, were included. RESULTS: There were 26 MMP (46%) and 31 PV (54%) patients. Desquamative gingivitis was evident in 84% of MMP cases compared to 26% of PV cases (p<0...
January 13, 2017: Oral Diseases
Natsumi Fujiwara, Keiji Murakami, Michiyasu Nakao, Munehisa Toguchi, Hiromichi Yumoto, Takashi Amoh, Katsuhiko Hirota, Takashi Matsuo, Shigeki Sano, Kazumi Ozaki, Yoichiro Miyake
OBJECTIVE: Halitosis is caused by volatile sulfur compounds including methyl mercaptan (CH3 SH) in the oral cavity and is a serious problem that limits interpersonal social communication. The aim of study was to evalute the effects of reuterin-related compounds (RRCs) on halitosis-related periodontopathic bacteria in vitro. MATERIALS AND METHODS: RRC-01, -02 and -03 (32 and 64 μg/mL) in culture media containing Fusobacterium nucleatum JCM8523 and Porphyromonas gingivalis ATCC33277 were used...
January 13, 2017: Oral Diseases
Kazuyuki Ishihara
The oral cavity is a habitat for a large number of microorganisms. More than 700 taxa of bacteria colonize the oral cavity (Human Oral Microbiome Database, release 13; and form an organized oral microflora. The composition of the microflora in the oral cavity is different in each area of the cavity, reflecting the physiological conditions (Simon-Soro et al., 2013). This article is protected by copyright. All rights reserved.
January 13, 2017: Oral Diseases
Galit Almoznino, Yaron Haviv, Yair Sharav, Rafael Benoliel
In this review we discuss the management of chronic orofacial pain (COFP) patients with insomnia. Diagnostic work-up and follow-up routines of COFP patients should include assessment of sleep problems. Management is based on a multidisciplinary approach, addressing the factors that modulate the pain experience as well as insomnia and including both non-pharmacological and pharmacological modalities. Parallel to treatment, patients should receive therapy for co-morbid medical and psychiatric disorders, and possible substance abuse that may be that may trigger or worsen the COFP and/or their insomnia...
January 11, 2017: Oral Diseases
Di Shan, Hu Long, Wenli Lai
We would like to congratulate Kun et al. (Kun et al., 2016) for their recent publication entitled: "TRPA1 receptor is upregulated in human oral lichen planus". This article is very informative and enlightening, and it was a great read. The authors pioneered the research into the role of a mechanosensory receptor-TRPA1-in the pathogenesis of oral lichen planus (LP). Based on the results of this study and others, we would like to put forward a hypothesis that TRPA1 participates in the Koebner phenomenon of oral lichen planus and contribute to its exacerbation (Figure 1)...
January 9, 2017: Oral Diseases
E Giorgini, S Sabbatini, C Conti, C Rubini, R Rocchetti, M Fioroni, L Memè, G Orilisi
OBJECTIVES: FTIR Microspectroscopy let characterize the macromolecular composition and distribution of tissues and cells, by studying the interaction between infrared radiation and matter. Therefore, we hypothesize to exploit this analytical tool in the analysis of inflamed pulps, to detect the different biochemical features related to various degrees of inflammation. MATERIALS AND METHODS: IR maps of 13 irreversible and 12 hyperplastic pulpitis, together with 10 normal pulps, were acquired, compared with histological findings and submitted to multivariate (HCA, PCA, SIMCA) and statistical (one-way ANOVA) analysis...
January 9, 2017: Oral Diseases
Shikha Gupta, Sujoy Ghosh, Sunita Gupta
OBJECTIVE: This narrative review focuses on the rationale & role of conventional and newer therapies in the management of Oral lichen planus with emphasis on randomized controlled trials reported over 2 decades. MATERIALS AND METHODS: Literature search was conducted to identify randomized controlled trials for management of OLP from 1/1/1995 to 31/12/2015; Medline, and Cochrane databases complemented with manual search was used. Primary outcome as resolution of pain was evaluated with analysis of clinical resolution of erythema and ulceration as secondary outcome...
January 5, 2017: Oral Diseases
Yaron Haviv, Avraham Zini, Galit Almoznino, Na'ama Keshet, Yair Sharav, Doron J Aframian
OBJECTIVE: Oral appliances (OA) are recommended for patients with severe obstructive sleep apnea who fail to comply with continuous positive airway pressure (CPAP) therapy. This mixed methods study aimed to quantify adherence to OA therapy and evaluate subjective reasons associated with non-adherence. MATERIALS AND METHODS: The medical records of 52 patients with an apnea-hypopnea index (AHI) ≥ 40, treated with OA after discontinuation of CPAP treatment, were examined for OA adherence...
January 5, 2017: Oral Diseases
Ppl Fung, G Bedogni, A Bedogni, A Petrie, S Porter, G Campisi, J Bagan, V Fusco, G Saia, S Acham, P Musto, M T Petrucci, P Diz, G Colella, M D Mignogna, M Pentenero, P Arduino, G Lodi, C Maiorana, M Manfredi, P Hallberg, M Wadelius, K Takaoka, Y Y Leung, R Bonacina, M Schiødt, P Lakatos, T Taylor, G De Riu, G Favini, S N Rogers, M Pirmohamed, P Nicoletti, S Fedele
OBJECTIVES: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. SUBJECTS AND METHODS: Retrospective analysis of data from 22 secondary care centres in 7 countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012...
December 31, 2016: Oral Diseases
Shereen Ali, Walaa Wahbi
OBJECTIVES: The main objective of oral lichen planus management is to control symptomatic outbreaks via eliminating lesions and alleviating symptoms. Corticosteroids; calcineurin inhibitors and most of the available modalities are associated with adverse effects which may limit their use. The aim of this review was to assess the effect of Aloe Vera on pain alleviation and/or clinical improvement in patients with symptomatic oral lichen planus. METHODS: MEDLINE-PubMed; CENTRAL and LILACS were searched in May, 2016 to identify all clinical trials evaluating Aloe Vera versus placebo or corticosteroids for treatment of oral lichen planus...
December 28, 2016: Oral Diseases
Nataly Kravchenko-Balasha, Aframian J Doron
Infections in the maxillofacial complex, including the oral cavity, are common and in certain cases may develop into a severe condition with life threating complications in healthy populations but especially in medical compromised patients (Moazzam et al, 2015). Often, treatment is based on personal experts' experience with limited accuracy obtained from diagnostic laboratory tests. Consequently, "trial and error" attempts are usually implemented until success, in the best case, is accomplished. As a result, there is a pressing need in clinical practice for developing efficient tools for understanding the pathological nature of the infection and its rapid identification based on infection biomarkers...
December 28, 2016: Oral Diseases
Adeline Braud, Vianney Descroix, Marie-Noëlle Ungeheuer, Catherine Rougeot, Yves Boucher
OBJECTIVE: Idiopathic Burning mouth syndrome (iBMS) is characterized by oral persistent pain without any clinical or biological abnormality. The aim of the present study was to evaluate taste function in iBMS subjects and healthy controls. MATERIAL AND METHODS: Electrogustometric thresholds (EGMt) were recorded in 21 iBMS patients and 21 paired matched controls at nine loci of the tongue assessing fungiform and foliate gustatory papillae function. Comparison of EGMt was performed using the non-parametric Wilcoxon signed-rank test...
December 28, 2016: Oral Diseases
Leonardo Nogueira Rodrigues, Sílvia Ferreira Sousa, Raissa Cristina Costa Silva, Mauro Henrique Guimarães Abreu, Fábio Ramôa Pires, Ricardo Alves Mesquita, Luciana Bastos-Rodrigues, Luiz De Marco, Carolina Cavaliéri Gomes, Ricardo Santiago Gomez, Vanessa Fátima Bernardes
BACKGROUND: The amalgam-associated oral lichenoid lesion (AAOLL) shows clinical and histopathological features similar to oral lichen planus (OLP). Molecular researches to improve knowledge of pathogenesis and clinical behavior of AAOLL are still scarce. OBJECTIVE: We investigated for the first time the use of LOH as a molecular approach for genetic characterization of AAOLL in comparison with OLP and evaluated the cell proliferation index. MATERIALS AND METHODS: The sample comprised nine AAOLLs, 10 OLPs and eight NOMs matched by patients' gender and age...
December 27, 2016: Oral Diseases
Monisha Billings, Bruce A Dye, Timothy Iafolla, Margaret Grisius, Ilias Alevizos
INTRODUCTION: Oral candidiasis (OC) is a potential oral complication in Sjögren's Syndrome (SS). Some studies indicate that the low stimulated salivary flow and not low unstimulated salivary flow is associated with OC in SS, while others report that the underlying autoimmune disorders contributes to OC, based solely on correlation coefficients. Given the conflicting and limited existing evidence, we purposed to ascertain the role of both salivary gland dysfunction (hyposalivation based on unstimulated and stimulated flow rates) and autoimmunity (SS, other autoimmune disorders) in OC among those with SS, other salivary gland dysfunction and non-salivary gland dysfunction controls (NSGD)...
December 20, 2016: Oral Diseases
Çiğdem Coşkun Türer, Umut Ballı, Berrak Güven
OBJECTIVES: The present study is evaluating fetuin-A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease. MATERIAL AND METHODS: Sixty patients were divided into three groups: Group 1 periodontal health (n=20), group 2 gingivitis (n=20) and group 3 chronic periodontitis (CP) (n=20). GCF and serum samples were evaluated using enzyme linked immunosorbent assay kit...
December 20, 2016: Oral Diseases
Anna Greta Barbe, Anja Heinzler, Sonja Henny Maria Derman, Martin Hellmich, Lars Timmermann, Michael Johannes Noack
OBJECTIVE: Parkinson's disease (PD) adversely affects oral health (OH). However, the informative value of xerostomia compared to objective parameters and its impact on quality of life (QoL) is still unclear. This study aimed to explore whether xerostomia correlates with hyposalivation and to define its impact on OH-related QoL. MATERIALS AND METHODS: Whole stimulated saliva (WSS) was collected from 30 PD patients and 30 matched healthy controls. Objective parameters (Community Periodontal Index of Treatment Needs, plaque/ gingivitis index, mucosa situation and cheilitis angularis), and questionnaires (German Oral Health Impact Profile [OHIPG]-14, visual analogue scale [VAS], xerostomia [yes/no], and the Unified Parkinson's Disease Rating Scale-II) were assessed...
December 14, 2016: Oral Diseases
Vamsee D Myneni, Eva Mezey
All living tissues require essential nutrients such as amino acids, fatty acids, carbohydrates, minerals, vitamins, and water. The skeleton requires nutrients for development, maintaining bone mass and density. If the skeletal nutritional requirements are not met, the consequences can be quite severe. In recent years, there has been growing interest in promotion of bone health and inhibition of vascular calcification by Vitamin K2. This vitamin regulates bone remodeling, an important process necessary to maintain adult bone...
December 14, 2016: Oral Diseases
Filipe Nobre Chaves, Thâmara Manoela Marinho Bezerra, Paulo Goberlânio de Barros Silva, Francisco Artur Forte Oliveira, Fabrício Bitu Sousa, Fábio Wildson Gurgel Costa, Ana Paula Negreiros Nunes Alves, Karuza Maria Alves Pereira
OBJECTIVES: To evaluate the expression of p-AKT, p-JNK, FoxO3a and KI-67 in samples of Oral Squamous Cell Carcinoma (OSCC) and Oral Epithelial Dysplasias (OEDs) to understand their possible involvement in the malignant transformation process of oral lesions. MATERIALS AND METHODS: Tissue samples of 20 cases of OSCCs, 20 OEDs and normal oral mucosa were subjected to immunohistochemistry reactions for anti-p-Akt, anti-p-JNK, anti-FoxO3a and anti-Ki-67 antibodies. It was analyzed quantitative (number of immunostained cells) and qualitative (immunostaining intensity) parameters in different cell immunostaining sublocations...
December 14, 2016: Oral Diseases
Pablo Ramos-García, José Antonio Gil-Montoya, Crispian Scully, Ángela Ayén, Lucía González-Ruiz, Francisco-José Navarro-Triviño, Miguel Ángel González-Moles
Cyclin D1 promotes cell cycle progression during G1 phase, a key event in G1-S transition. The protein is encoded by gene CCND1, located in chromosomal band 11q13. Cyclin D1 plays key roles in cell biology, including: cell proliferation and growth regulation, mitochondrial activity modulation, DNA repair, and cell migration control. CCND1 gene and its protein cyclin D1 are frequently altered by different molecular mechanisms, including amplification, chromosomal translocations, mutations, and activation of the pathways involved in cyclin D1 expression, alterations which appear to be essential in the development of human cancers, including oral carcinoma...
December 14, 2016: Oral Diseases
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