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Oral Diseases

Rodrigo A Giacaman
The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugar in caries. In fact, current definition points towards an ecological disease caused by the commensal microbiota that under ecological imbalances, mainly due to high and or frequent sugar consumption, creates a state of dysbiosis in the oral biofilm...
September 12, 2017: Oral Diseases
Kota Tsutsumi, Masato Maruyama, Akira Uchiyama, Ken-Ichiro Shibasaki
OBJECTIVES: Sugar consumption has been decreasing in Japan, suggesting higher rates of sucrose-independent supragingival plaque formation. For developing an in vitro biofilm model of sucrose-independent supragingival plaque, this study aimed to investigate the compositions and functions on contributing to cariogenicity in comparison with sucrose-dependent biofilm. MATERIALS AND METHODS: An in vitro multispecies biofilm containing Actinomyces naeslundii, Streptococcus gordonii, S...
September 12, 2017: Oral Diseases
Matti Mauramo, Adrian M Ramseier, Elina Mauramo, Andreas Buser, Taina Tervahartiala, Timo Sorsa, Tuomas Waltimo
OBJECTIVE: MMP-8 is a prominent collagenase in periodontal disease. This cross-sectional study examined whether MMP-8 levels in saliva and gingival crevicular fluid (GCF) are associated with periodontitis in a Swiss population. SUBJECTS AND METHODS: 258 subjects (107 m, 151 f, mean age: 43.5 yr; range: 21-58 yr) acquired from the Swiss bone marrow donor registry participated in the study. Saliva and GCF samples were collected from subjects followed by a thorough dental and periodontal examination...
September 10, 2017: Oral Diseases
Hyun-Chang Lim, Byung-Yoon Cha, Sun U Song, Jeong-Ho Yun
OBJECTIVE: to investigate whether harmine has a promotive effect on human periodontal ligament cells (hPDLCs)-induced tissue regeneration. MATERIALS AND METHODS: Various concentrations of harmine on hPDLCs proliferation were tested. Osteogenic and cementogenic characteristics were examined in hPDLC/rhBMP-2 and hPDLC/harmine by alizarin red S staining, real-time PCR, and Western blotting assay. The activity of harmine was investigated in an ectopic transplantation nude mouse model...
September 10, 2017: Oral Diseases
Ana Luiza Dias Leite de Andrade, Carine Ervolino de Oliveira, Maurício Rocha Dourado, Carolina Carneiro Soares Macedo, Flávia Vischi Winck, Adriana Franco Paes Leme, Tuula Salo, Ricardo D Coletta, Roseana de AlmeidaFreitas, Hébel Cavalcanti Galvão
BACKGROUND: A new intercellular communication mode established by neoplastic cells and tumor microenvironment components is based on extracellular vesicles (EVs). However, the biological effects of the EVs released by tumor cells on angiogenesis are not completed understood. Here we aimed to understand the biological effects of EVs isolated from two cell lines of oral squamous cell carcinoma (OSCC) (SCC15 and HSC3) on endothelial cell tubulogenesis. METHODS: OSCC-derived EVs were isolated with a polymer-based precipitation method, quantified using nanoparticle tracking analysis and verified for EV markers by dot-blot...
September 8, 2017: Oral Diseases
Duangporn Kerdpon, Kitti Jantharapattana, Hutcha Sriplung
OBJECTIVES: To evaluate the impact of more open access to health services by Thailand's universal health coverage (UHC) on diagnostic delay of oral squamous cell carcinomas (OSCC) by comparing results with our previous study prior to the UHC. Reasons for delay in attending health care professionals (HCPs) consultation were also investigated. METHODS: A structure questionnaire was employed to interview 154 OSCC consecutive patients. Variables were included for Cox proportional regression models to conclude the hazard ratio of each delay...
September 1, 2017: Oral Diseases
Xiao Cen, Yan Liu, Shasha Wang, Xianrui Yang, Zongdao Shi, Xinhua Liang
OBJECTIVE: To investigate the therapeutic effect of oral glucosamine (GS) as an adjunct to hyaluronic acid (HA) injection on patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS: In this clinical trial, 136 participants, diagnosed as TMJ OA clinically and radiographically, were enrolled and randomized into two groups (Group GS+HA: oral GS+HA injection; Group placebo+HA: oral placebo+HA injection). Pain, maximum inter-incisal mouth opening (MMO), the levels of IL-1β, IL-6, and TGF-β in TMJ synovial were defined as the outcome measurements and conducted before operation, and at 1-month, 1-year follow-up...
September 1, 2017: Oral Diseases
Patrícia Azevedo Lino, Carolina de Castro Martins, Gabriel Ferreira Pessoa Carvalho Miranda, Maria Elisa de Souza E Silva, Mauro Henrique Nogueira Guimarães de Abreu
OBJECTIVE: Previous research has suggested that antidepressants can be used in oral health care. The aim of this systematic review was to search for scientific evidence of the efficacy of the use of antidepressants in dentistry. MATERIALS AND METHODS: The clinical question was as follows (PICO Question): dentistry patients (Patients); antidepressants (Intervention); no use or placebo or other drug (Comparison); efficacy in oral health problems (Outcome). An electronic search was conducted in seven databases, as well as a manual search without restriction regarding language and date of publication...
August 24, 2017: Oral Diseases
Soraia de Fátima Carvalho Souza, Halinna Larissa Cruz Correia de Carvalho, Cyrene Piazera Costa Silva, Erika Bárbara Abreu Fonseca Thomaz
OBJECTIVE: To estimate the association between sickle cell anaemia or trait with dental and jaw bone abnormalities. SUBJECTS AND METHODS: Subjects (n=369) were allocated to three groups: sickle cell anaemia, trait and control. Dental shape, number, size and position and changes in pulp chamber, root and periapex were analysed by intra-oral periapical radiographs. Integrity of lamina dura, quality of cancellous bone and bone trabeculation were also evaluated. Prevalence ratios (PR) were calculated (α=0...
August 20, 2017: Oral Diseases
Mohammad Aldosari, Tais Scaramucci, Sean Shih-Yao Liu, Janice M Warrick-Polackoff, George J Eckert, Anderson T Hara
OBJECTIVES: To investigate the susceptibility of partially-desalivated rats to erosive tooth wear (ETW); the anti-erosive effect of a calcium-supplemented beverage; and the quantification of ETW by micro-computed tomography (micro-CT). METHODS: The study population consisted of thirty-eight rats, divided into partially-desalivated (n=19) and normal salivary flow (n=19). They were randomly allocated into 3 subgroups (n=6-7): A-diet soda, B-diet soda+calcium, C-water (control)...
August 20, 2017: Oral Diseases
Min Xu, Lan Ma, Shu Lou, Du Yifei, Xiaoqing Yin, Chi Zhang, Liwen Fan, Hua Wang, Zhendong Wang, Weibing Zhang, Lin Wang, Yongchu Pan
OBJECTIVE: MicroRNAs (miRNAs) processing genes play important roles in the craniofacial development. The aim of the present study was to explore the associations between single nucleotide polymorphisms (SNPs) of miRNA processing genes with the risk of non-syndromic orofacial clefts (NSOC). METHODS: We genotyped 12 potentially functional SNPs from seven miRNA processing genes (GEMIN3, DROSHA, DGCR8, GEMIN4, PIWIL1, XPO5, and DICER) in a case-control study of 602 NSOC cases and 605 controls...
August 20, 2017: Oral Diseases
Gábor Varga, Pamela DenBesten, Róbert Rácz, Ákos Zsembery
Dental enamel, the hardest mammalian tissue, is produced by ameloblasts. Ameloblasts show many similarities to other transporting epithelia although their secretory product, the enamel matrix, is quite different. Ameloblasts direct the formation of hydroxyapatite crystals, which liberate large quantities of protons that then need to be buffered to allow mineralization to proceed. Buffering requires a tight pH regulation and secretion of bicarbonate by ameloblasts. Many investigations have used immunohistochemical and knock-out studies to determine the effects of these genes on enamel formation, but up till recently very little functional data was available for mineral ion transport...
August 18, 2017: Oral Diseases
Kaliane Rocha Soledade-Marques, Isaac Suzart Gomes-Filho, Simone Seixas da Cruz, Johelle de Santana Passos-Soares, Soraya Castro Trindade, Eneida de Moraes Marcílio Cerqueira, Julita Maria Freitas Coelho, Maurício Lima Barreto, Maria da Conceição Nascimento Costa, Maria Isabel Pereira Vianna, Frank A Scannapieco, Álvaro Augusto Cruz, Adelmir Souza-Machado
OBJECTIVE: To evaluate the association between periodontitis and severe asthma, with participants in treatment for severe asthma, controlled by therapy. METHODS: A case-control investigation was performed to compare 130 adults with severe asthma with 130 without asthma. Individuals with periodontitis were those with ≥ 4 teeth with ≥ 1 site with probing depth ≥ 4 mm, clinical attachment level ≥ 3 mm, and bleeding upon probing at the same site. Severe asthma diagnosis was based on Global Initiative for Asthma criteria...
August 18, 2017: Oral Diseases
Ge Feng, Yan Wu, Yu Yong, Lan Huang, Shu An, Bo Hu, Jun Luo, Jinlin Song
OBJECTIVE: In this study, we constructed a composite by combining the human dental follicle cell sheet and a manual drilled porous decalcified dentin matrix that was used to construct ectopic tissue-engineered periodontal ligament-like tissues in renal capsules of nude mice. MATERIALS AND METHODS: Human dental follicle cells were harvested from human lower third molars and then embedded into a temperature-sensitive culture dish. These cells were then placed into frozen porous decalcified dentin matrix sheets and induced by 50 g/ml ascorbic acid...
August 16, 2017: Oral Diseases
Önder Gürlek, Pınar Gümüş, Nurcan Buduneli
AIM: To comparatively evaluate peri-implant health status in smokers and non-smokers. MATERIALS AND METHODS: A total of 142 implants (74 implants in non-smokers, 68 in smokers) in 43 smoker or non-smoker systemically healthy patients were included in the study. Demographic and clinical periodontal data were recorded and analysed by Chi-square and Mann-Whitney U tests. RESULTS: Peri-implantitis and mucositis cases were significantly more frequent in the smokers than non-smokers (p=0...
August 11, 2017: Oral Diseases
Alpdogan Kantarci, Hatice Hasturk
The human body hosts billions of microorganisms. According to one estimate, the ratio of bacterial cells to human cells is 10:1. There are an enormous diversity and specificity based on where the species live and how they interact with each other as well as the host. While bacterial species define how the host lives and adapts to its environment, host-associated factors also determine the microbiome and its components. This article is protected by copyright. All rights reserved.
August 11, 2017: Oral Diseases
Qiao Shi Xu, Chong Wang, Bo Li, Jin Zhong Li, Ming Hui Mao, Li Zheng Qin, Hua Li, Xin Huang, Zhengxue Han, Zhien Feng
OBJECTIVE: The purposes of this study were to explore both the prognostic value of pathologic grade and the relationships between differentiation and clinicopathological characteristics in oral squamous cell carcinoma. METHODS: This retrospective cohort study included the records of 2036 patients with oral squamous cell carcinoma who were surgically treated from June 1999 to December 2011. Chi square test, Kaplan-Meier analysis and Cox proportional-hazards regression model were performed for statistical analysis...
August 8, 2017: Oral Diseases
Paswach Wiriyakijja, Stefano Fedele, Stephen Porter, Valeria Mercadante, Richeal Ni Riordain
OBJECTIVES: To analyse the range of existing patient-reported outcome measures (PROMs) used in studies of recurrent aphthous stomatitis (RAS) and to evaluate their quality properties via the assessment of psychometric properties and interpretability. MATERIALS AND METHODS: Electronic databases were searched to identify relevant publications related to PROMs used in RAS. Publications were selected based on predefined criteria. All identified PROMs were then classified by measuring concepts and assessed for instrument characteristics and evidence for quality properties for RAS patients...
August 5, 2017: Oral Diseases
J M Trevillyan, J J Chang, J S Currier
We read with great interest your special edition 'The Mouth and AIDS' (Vol 22, Supplement S1, April 2016) which highlighted the important and oft ignored issue of oral health in people living with HIV. Oral disease appears common in the setting of HIV, with rates of chronic periodontitis reported to be as high as 76% in HIV-positive individuals (Kroidl, Schaeben, Oette et al., 2005), This article is protected by copyright. All rights reserved.
August 5, 2017: Oral Diseases
Rym Kammoun, Catherine Behets, Lamia Mansour, Sonia Ghoul-Mazgar
To explore the mineral features of dentin and cementum in hypoplastic AI teeth MATERIALS AND METHODS: Forty four (44) teeth cleaned and free of caries were used: 20 control and 24 affected by hypoplastic amelogenesis imperfecta. Thirty-two teeth were studied by pQCT, cut in sections and analysed under microradiography, polarized light microscopy and confocal Raman spectroscopy. Eight teeth were observed under scanning electron microscope. Four teeth were used for an X-ray diffraction. The mineral density data were analysed statistically with the Mann-Whitney U test, using GraphPad InStat Software RESULTS: Both coronal and radicular dentin were less mineralized in AI teeth when compared to control (respectively 6...
August 3, 2017: Oral Diseases
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