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Oral Diseases

Stephen Sonis, Paulette Wright Andreotta, Gregory Lyng
OBJECTIVE: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions. Our objective was to assess the utility of a new organotypic model in defining mIAS' pathogenesis. MATERIALS AND METHODS: The effect of everolimus on organotypic human oral mucosa was studied. Sterile specimens were assessed 24 hr and 48 hr after exposure to varying concentrations of everolimus...
November 29, 2016: Oral Diseases
R Nagler
In a recent study published in the Proceedings of the National Academy of Sciences of the U.S.A., Jau-Song Yu et al reported of their generated four-protein biomarker panel consisting of MMP1, KNG1, ANXA2, and HSPA5, as based on a risk-score scheme they established (Yu et al, 2016). This panel showed high sensitivity (87.5%) and specificity (80.5%) values in a test set to distinguish OSCC patients' saliva samples from non-OSCC patients' saliva samples. The risk score >0.4 detected 84% of the stage I OSCCs and a significant portion (42%) of the high-risk, visible, oral potentially-malignant disorders (OPMDs)...
November 28, 2016: Oral Diseases
Joke Bradt, Aaron Teague
Anxiety is a significant issue in the dental care of adults and children. Dental anxiety often leads to avoidance of dental care which may result in significant deterioration of oral and dental health. Nonpharmacological anxiety management interventions such as music listening are increasingly used in dental care. Although efficacy for music's anxiolytic effects has been established for pre-operative anxiety, findings regarding the use of music listening for dental anxiety are inconclusive, especially for children...
November 25, 2016: Oral Diseases
Ilias Alevizos, Changyu Zheng, Ana P Cotrim, Corinne M Goldsmith, Linda McCullagh, Theodore Berkowitz, Susan L Strobl, Anatoli Malyguine, William C Kopp, John A Chiorini, Nikolay P Nikolov, Megan Neely, Gabor G Illei, Bruce J Baum
OBJECTIVES: The purpose of this study was to examine the humoral and cellular immune reactivity to adenoviral vector (AdhAQP1) administration in the human parotid gland over the first 42 days of a clinical gene therapy trial. METHODS: Of eleven treated subjects, five were considered as positive responders (Baum et al, 2012). Herein, we measured serum neutralizing antibody titers, circulating cytotoxic lymphocytes, and lymphocyte proliferation in peripheral blood mononuclear cells...
November 25, 2016: Oral Diseases
Laurent A M Thierens, Nele Brusselaers, Noëmi M C De Roo, Guy A M De Pauw
Labial adhesion is a preliminary surgical lip approximation used in the early management of unilateral and bilateral cleft lip and palate. Our objective was to evaluate its effects on the maxillary arch dimensions and nasolabial esthetics by means of a systematic review. The literature search (1955-2016) was based on MEDLINE via PubMed, Web of Science, Embase, and the Cochrane Library. Studies with labial adhesion as a single preliminary step for definitive lip closure, in combination with nasoalveolar molding or in combination with infant orthopedics were considered eligible...
November 23, 2016: Oral Diseases
Hu Long, Meiya Gao, Yafen Zhu, He Liu, Yang Zhou, Lina Liao, Wenli Lai
OBJECTIVES: To explore the effects of menstrual cycle on orthodontic pain following initial archwire engagement. METHODS: Female participants with regular menstrual cycles were recruited and assigned into follicular group or luteal group. Demographical and baseline variables were collected: age, education, menstrual duration, anxiety, oral health impact profile-14 (OHIP-14) and index of complexity outcome and need (ICON). Following initial archwire engagement, orthodontic pain was determined through visual analogue scale (VAS) on 1(st) day, 2(nd) day and 3(rd) day...
November 22, 2016: Oral Diseases
Monisha Billings, Gabriela Lopez Mitnik, Bruce A Dye
The gold standard of study design in clinical investigation is the randomized controlled trial (RCT). Over the past 50 years, RCTs have come to be considered the primary source of evidence for the efficacy of newer therapeutic interventions (Matthews, 2006). The design of the trial varies with the phase of the clinical trial (I-IV) and is dependent on several statistical exercises. Typically, sample size calculation and statistical power are critical components of study design. This article is protected by copyright...
November 21, 2016: Oral Diseases
Palle Holmstrup, Bjarne Klausen
Antibiotic therapy over the years has saved millions of lives, but antimicrobial resistance (AMR) is a current threat to human health. An interesting review on AMR has recently been presented in the Journal of American Medical Association (Marston et al., 2016). The review is authored by five staff members at National Institutes of Health in Bethesda, Maryland, and the purpose of the review was to identify factors associated with AMR, the current epidemiology of important resistant organisms, and possible solutions to the AMR problem...
November 17, 2016: Oral Diseases
Haixia Zhang, Zhangui Tang, Chao Deng, Yan He, Fang Wu, Ousheng Liu, Chunhong Hu
OBJECTIVE: To analyze the effects of HMGA2 on proliferation, invasion and metastasis in tongue squamous cell carcinoma (TSCC). METHODS: HMGA2-knockdown was performed in SCC15 cell lines and functional assay was applied to observe the effects on cell migration and invasion. Real time-PCR, western blotting and immunohistochemistry (IHC) were also used to measure the expression of HMGA2 and EMT markers. RESULTS: HMGA2 expression was decreased after lentivirus infection...
November 3, 2016: Oral Diseases
N G Nikitakis
The PI3K/AKT/mTOR intracellular signaling pathway is frequently activated in a wide variety of malignant neoplasms, controlling many cancer-related biological processes, such as cell growth and survival, protein translation, cytoskeletal organization and metabolism (Polivka and Janku, 2014; Moschetta et al, 2014). In Head and Neck Squamous Cell Carcinoma (HNSCC), aberrant activation of the mTOR pathway is regarded as one of the prevailing cell signaling abnormalities in both HPV- and HPV+ cancers, representing a point of convergence of various genetic and epigenetic alterations (Iglesias-Bartolome et al, 2013)...
November 3, 2016: Oral Diseases
M Pentenero, M Monticone, R Marino, C Aiello, G Marchitto, D Malacarne, W Giaretti, S Gandolfo, P Castagnola
OBJECTIVES: DNA aneuploidy has been reported to be a predictor of poor prognosis in both premalignant and malignant lesions. In oral lichen planus (OLP) this hypothesis remains to be proved. This study aims to determine the rate of occurrence of DNA aneuploidy in OLP patients by high-resolution DNA flow cytometry. METHODS: OLP patients were consecutively enrolled. Tissue samples were subdivided for formalin fixation and routine histological assessment and for immediate storage at -20°C for later DNA ploidy analysis, which was performed by DAPI staining of the extracted nuclei and excitation with a UV lamp...
November 1, 2016: Oral Diseases
Chun-Shu Wong, Elizabeth S Richards, Luxin Pei, Irini Sereti
In this review we will describe the immunopathogies of immune reconstitution inflammatory syndrome, IRIS. IRIS occurs in a small subset of HIV patient, initiating combination antiretroviral therapy (ART), where immune reconstitution becomes dyregulated, resulting in an overly robust antigen-specific inflammatory reaction. We will discuss IRIS in terms of the associated coinfections: mycobacteria, cryptococci, and viruses. This article is protected by copyright. All rights reserved.
November 1, 2016: Oral Diseases
Roy Xiao, Carter Van Waes, Nicole C Schmitt
The recent genomic characterization of head and neck squamous cell carcinomas by The Cancer Genome Atlas demonstrated the high frequency of mutations affecting these cancers (Cancer Genome Atlas Network, 2015). This high rate of genomic alterations allows head and neck cancers to be highly immunogenic, thus promoting responses to immune therapies (Allen et al, 2015; Ferris, 2015). For instance, inhibitors of immune checkpoints like the anti-PD-1 monoclonal antibodies nivolumab and pembrolizumab have demonstrated promising results in head and neck cancer (Ferris et al, 2016; Chow et al, 2016), both recently receiving FDA approval in the setting of recurrent or metastatic disease...
October 31, 2016: Oral Diseases
Tami Yap, Laura Vella, Christine Seers, Alf Nastri, Eric Reynolds, Nicola Cirillo, Michael McCullough
: MicroRNAs are small non-coding RNAs which are dysregulated in disease states, such as oral cancer. Extracellular vesicles, a potential source of microRNA, are found in saliva. OBJECTIVE: To demonstrate that a quantifiable amount of microRNA can be isolated from oral swirl samples. Additionally, we hypothesized that extracellular vesicles may protect contained microRNA from degradation in these samples. METHOD: A polyethylene glycol based precipitation was used for extracellular vesicle enrichment of oral swirl samples...
October 31, 2016: Oral Diseases
Yu-Jin Kwon, Kug-Jin Jeon, Tae-Ha Chung, Yong-Jae Lee
OBJECTIVE: Both an elevated leukocyte count and periodontitis share well-recognized associations with cardiometabolic diseases. This cross-sectional study aimed to identify whether the leukocyte count is associated with periodontitis in a nationally-representative Korean adult population. MATERIALS AND METHODS: Data from 9,391 participants (3,659 males and 5,732 females) enrolled in 2012-2014 Korean National Health and Nutrition Examination Survey were analyzed...
October 26, 2016: Oral Diseases
Yi-Cun Li, Lin-Lin Bu, Liang Mao, Si-Rui Ma, Jian-Feng Liu, Guang-Tao Yu, Wei-Wei Deng, Wen-Feng Zhang, Zhi-Jun Sun
OBJECTIVE: Our aim is to evaluate the expression of SATB1 in human oral squamous cell carcinomas (OSCC) and its role in the invasiveness and metastasis of OSCC. SUBJECTS AND METHODS: A human OSCC tissue microarray was used to evaluate the expression pattern of SATB1. SATB1 mRNA knockdown was performed in human OSCC cell lines SCC25 and Cal27 to assess the function of SATB1 in the invasiveness and metastasis of OSCC. RESULTS: SATB1 is highly expressed in human OSCC determined by immunohistochemistry and its nuclear/cytoplasmic ratio of histoscore is significantly correlated with patients' prognosis...
October 26, 2016: Oral Diseases
Ibrahim Oghli, Thomas List, Mike John, Pernilla Larsson
OBJECTIVES: To (i) determine the prevalences of self-report in a Swedish adult population, of temporomandibular disorders, burning mouth syndrome, dry mouth, and bad breath and (ii) determine oral health-related quality of life impairment in subjects reporting these conditions. SUBJECTS AND METHODS: A cross-sectional, randomized sample of the adult Swedish population (response rate: 46%, N=1309 subjects) self-reported their condition from the preceding month to assess prevalences of self-report for the studied conditions together with comorbidity group of subjects who reported more than one condition...
October 22, 2016: Oral Diseases
Loreto Abusleme, Niki M Moutsopoulos
Interleukin-17 (IL-17) is a multifaceted cytokine with diverse roles both in immune-protection and also immunopathology. IL-17 has a well-recognized role in immune surveillance at mucosal and barrier surfaces (Miossec & Kolls, 2012, Song et al., 2016) but also has been increasingly implicated as a driver of immunopathology in settings of autoimmunity and chronic inflammation (Gaffen et al., 2014). This article is protected by copyright. All rights reserved.
October 20, 2016: Oral Diseases
Tianyi Cao, Han Zhang, Leilei Zhou, Yufeng Wang, Guanhuan Du, Hui Yao, Yanni Wang, Qingqiong Luo, Fuxiang Chen, Wanchun Wang, Guoyao Tang
OBJECTIVES: The aim of this study was to optimize the culture system of keratinocytes obtained from oral lichen planus (OLP) patients and verify whether this model could simulate the local inflammatory environment of OLP. MATERIALS AND METHODS: Keratinocytes were isolated from 48 OLP patients and cultured in vitro. The ultrastructure of OLP keratinocytes was observed via electron microscopy. The expression of pancytokeratin and vimentin was determined by immunohistochemistry, and the proliferation of OLP keratinocytes was measured by CCK-8 assay...
October 20, 2016: Oral Diseases
Sarah F M Pilati, Bianca C Bianco, Daniella S C Vieira, Filipe Modolo
OBJECTIVE: This study aimed to determine the histopathological findings in actinic cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from AC to LSCC based on the comparison of two dysplasia classification systems. METHODS: Histopathological features were evaluated according to the World Health Organization classification of dysplasia and binary system of classification...
October 19, 2016: Oral Diseases
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