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Oral Diseases

Ikuho Kojima, Maya Sakamoto, Masahiro Iikubo, Yusuke Shimada, Takashi Nishioka, Takashi Sasano
OBJECTIVE: We analysed the correlation between magnetic resonance images of the parotid and submandibular glands and the salivary flow rate in patients with Sjögren's syndrome. METHODS: We retrospectively reviewed magnetic resonance images (heterogeneous signal-intensity distribution and gland volume on T1- and fat-suppressed T2-weighted images, and multiple high-signal-intensity spots on magnetic resonance sialograms in the parotid and submandibular glands) obtained from 66 patients who were diagnosed with Sjögren's syndrome...
July 14, 2018: Oral Diseases
Giancarlo Tirelli, Alberto Vito Marcuzzo, Francesca Boscolo Nata
OBJECTIVE: Narrow-band imaging is widely used in the diagnostic work-up of oral lesions. Different oral subsites present three epithelial types (1, 2a, 2b), each with a different structure and function. The aim of this study was to analyse and describe the different vascular patterns seen on narrow-band imaging according to oral epithelial type and histology. MATERIALS AND METHODS: The narrow-band imaging photographs of healthy, dysplastic and neoplastic oral mucosa were retrospectively reviewed and divided according to epithelial type and histology...
July 11, 2018: Oral Diseases
Katarzyna Gawron, Anna Ochała-Kłos, Zuzanna Nowakowska, Grzegorz Bereta, Katarzyna Łazarz-Bartyzel, Aleksander M Grabiec, Paweł Plakwicz, Renata Górska, Andrzej Fertala, Maria Chomyszyn-Gajewska, Jan Potempa
OBJECTIVES: To investigate the processes associated with the excessive production of collagen I in hereditary gingival fibromatosis (HGF). MATERIALS AND METHODS: Three HGF subjects and five controls were enrolled in the study. Histomorphological and immunohistological analyses were performed on gingival tissues. The expression of heat shock protein 47 (HSP47), collagen I, transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) by gingival fibroblasts isolated from HGF and controls was analysed using qRT-PCR, Western blotting and ELISA...
July 10, 2018: Oral Diseases
Mengchen Wang, Man Qin
OBJECTIVE: Dental caries is related to cariogenic bacteria, salivary components, oral hygiene, and host susceptibility. Lactoferrin is an important antimicrobial glycoprotein in saliva; however, the role of the LTF gene in caries susceptibility is unclear. We investigated the association between LTF polymorphisms and the severity of caries. DESIGN: Our study included 910 healthy paediatric subjects (aged 24-48 months) categorised into three groups: 403 with no caries or white-spot lesions; 230 with moderate caries (8 ≤ dmft ≤ 12); and 277 with severe caries (13 ≤ dmft ≤ 20)...
July 10, 2018: Oral Diseases
Hani Mawardi, Shahrukh K Hashmi, Sharon Elad, Mahmoud Aljurf, Nathaniel Treister
The field of allogeneic hematopoietic cell transplantation (allo-HCT) began in the 1950s, and despite a seven decade history of remarkable clinical advances, graft-versus-host-disease (GVHD) remains the greatest obstacle in its success due to considerable morbidity and mortality.(Gratwohl et al., 2015) Graft-versus-host disease is the second leading cause of transplantation-related mortality (TRM) after relapse of primary disease.(Nassereddine et al., 2017) There are two main types of GVHD - acute and chronic - differing in the pathogenesis, time of onset, and clinical presentation (Figure 1)...
July 9, 2018: Oral Diseases
Enny-Sonia Xu, Muh-Hwa Yang, Shih-Che Huang, Chih-Yi Liu, Ting-Ting Yang, Teh-Ying Chou, Tzer-Zen Hwang, Chao-Tien Hsu
BACKGROUND: Endothelin-converting enzyme-1 (ECE-1) primarily converts Big Endothelins (ETs) into active Endothelin-1 (ET-1). However, the expression pattern and prognostication status of ECE-1 in head and neck cancer (HNC) are enigmatic. In this study, we investigated ECE-1 expression and assessed the roles of ECE-1 as a predictor for HNC differentiation and prognosis. MATERIAL AND METHODS: ECE-1 expressions were evaluated by immunohistochemical analysis using a tissue microarray (TMA) composed of 100 cases of head and neck squamous cell carcinoma...
July 6, 2018: Oral Diseases
Suganya Panneer Selvam, Irulandy Ponniah
OBJECTIVE: To analyse the immunohistochemical expression of ameloblastin in the bell stage of tooth germ and compare with ameloblastoma to determine the level of differentiation of tumour cells. STUDY DESIGN: The study included eleven human tooth germs with four in the early and seven in the late bell stages, and six selected archival tissue samples of ameloblastomas were studied using hematoxylin and eosin, Masson's trichrome and as well as ameloblastin. RESULTS: All eleven tooth germs reacted positively with ameloblastin with a characteristic inverted and sequential pattern of expression in the acellular zone of the dental papillae and enamel organ...
July 5, 2018: Oral Diseases
Yong Yoon, Tae-Jun Kim, Jae-Mok Lee, Do-Yeon Kim
OBJECTIVES: Periodontitis is a highly prevalent chronic inflammatory disease that results in destruction of tooth-supporting structures followed by tooth-loss. Until now, periodontitis has been regarded to be initiated by bacterial infection followed by aberrant host response. Although increasing evidence suggests a strong association between oxidative stress and periodontitis, precise molecular mechanism has been left unanswered. In this study, we investigated roles of SOD2, the main antioxidant enzyme maintaining reactive oxygen species (ROS) homeostasis, under inflammatory conditions...
July 4, 2018: Oral Diseases
Kausar Sadia Fakhruddin, Hien Chi Ngo, Lakshman Perera Samaranayake
Recent advances in the field of molecular microbiology provide an unprecedented opportunity to decipher the vast diversity of the oral microbiome in health and disease. Here, we provide a contemporary overview of the oral microbiome and the microbiota of Early Childhood Caries (ECC) with particular reference to newer analytical techniques. A MEDLINE search revealed a total of 20 metagenomic studies describing cariogenic-microbiomes of ECC, ten of which also detailed the healthy microbiomes. Additionally, seven studies on site-specific-microbiomes, focusing on acidogenic and aciduric-microbiota of deep-dentinal lesions were also reviewed...
July 3, 2018: Oral Diseases
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To investigate the impact of antirheumatic medications on salivary matrix metalloproteinase (MMP) -8 levels and MMP-8/TIMP (tissue inhibitor of MMPs)-1 ratio in patients with rheumatoid arthritis (RA) and periodontal findings during a 1-year follow-up. MATERIALS AND METHODS: Salivary MMP-8 was measured by an immunofluorometric assay and TIMP-1 by an enzyme-linked immunosorbent assay of 53 patients with early untreated RA (ERA), naïve to synthetic disease modifying antirheumatic drugs (DMARDs), of 28 patients with chronic RA (CRA), candidates for biologic DMARDs and of 43 age- and sex-matched controls...
July 3, 2018: Oral Diseases
Miao Yu, Sing-Wai Wong, Dong Han, Tao Cai
Tooth agenesis (TA) is one of the most common developmental anomalies that affects the number of teeth. An extensive analysis of publicly accessible databases revealed 15 causative genes responsible for non-syndromic TA, along with their signaling pathways in Wnt/β-catenin, TGF-β/BMP and Eda/Edar/NF-κB. However, genotype-phenotype correlation analysis showed that most of the causal genes are also responsible for syndromic TA or other conditions. In a total of 198 different mutations of the 15 genes responsible for non-syndromic TA, 182 mutations (91...
July 3, 2018: Oral Diseases
Xin Yang, Chang Xiao, Fen Liu, Fan Jian, Li'an Yang, Hong Nie, Jianyong Wu
OBJECTIVES: The present study aims to1) evaluate the stability of the parietal boneof beagles 6-9 months old, and 2) examine whetherparietal regional superimposition can provide an atraumatic and effective solution for further maxillary expansion study. MATERIALS AND METHODS: Six pre-pubertal 6 months old male beagles were included. Six miniscrew markers were inserted into the left and right sides of the parietal bone, andtwo of them were placed bilaterally near thepalatal suture...
June 29, 2018: Oral Diseases
Mohtasham Ghaffari, Sakineh Rakhshanderou, Ali Safari-Moradabadi, Sohila Torabi
OBJECTIVE: The present research aimed to investigate the effect of an educational intervention based on the health belief model in pregnant women visiting the healthcare centers in the west of Tehran in 2016. MATERIALS AND METHODS: The present experimental research was conducted on 135 pregnant women visiting the healthcare centers in the west of Tehran. The subjects were selected through a randomized multi-stratified sampling and were divided into an experimental and a control group...
June 27, 2018: Oral Diseases
Nunthawan Nowwarote, Thanakorn Theerapanon, Thanaphum Osathanon, Prasit Pavasant, Thantrira Porntaveetus, Vorasuk Shotelersuk
OBJECTIVE: To delineate oro-dental features, dental mineral density, genetic etiology, and cellular characteristics associated with amelogenesis imperfecta (AI). MATERIALS AND METHODS: Three affected patients in a family were recruited. Whole exome sequencing was used to identify mutations confirmed by sanger sequencing. The proband's teeth were subjected for mineral density analysis by micro-computerised tomography and characterisation of periodontal ligament cells (PDLCs)...
June 27, 2018: Oral Diseases
José Alcides Almeida de Arruda, Lauren Frenzel Schuch, Lucas Guimarães Abreu, Leni Verônica de Oliveira Silva, Carla Mosconi, João Luiz Gomes Carneiro Monteiro, Aline Carvalho Batista, Laura de Campos Hildebrand, Manoela Domingues Martins, Ana Paula Veras Sobral, Elena Riet Correa Rivero, Ana Paula Neutzling Gomes, Tarcília Aparecida Silva, Ana Carolina Uchoa Vasconcelos, Ricardo Alves Mesquita
OBJECTIVES: To investigate the frequency of oral paracoccidioidomycosis from representative geographic regions of Brazil, and to compare data with a literature review. MATERIALS AND METHODS: A retrospective study was conducted on 108,304 biopsies obtained from 1953 to 2016 at six Brazilian oral and maxillofacial pathology services. Demographic data and clinical and histopathological diagnosis of oral paracoccidioidomycosis were evaluated. A literature review of oral paracoccidioidomycosis studies published in three electronic databases was carried out...
June 27, 2018: Oral Diseases
Reyhan Ersin Kalkan, Figen Öngöz Dede, Ceren Gökmenoğlu, Cankat Kara
AIM: Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases. MATERIALS AND METHODS: A total of 54 subjects were divided in to three groups of 18 patients each; periodontally healthy, gingivitis, chronic periodontitis...
June 27, 2018: Oral Diseases
Thalita Soares Tavares, Daniela Pereira Meirelles, Maria Cássia Ferreira de Aguiar, Patrícia Carlos Caldeira
OBJECTIVES: To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa. MATERIALS AND METHODS: A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathologic specimens with diagnoses of any pigmented lesion were retrieved. Statistical analysis was performed using SPSS software. RESULTS: A total of 34,127 archived specimens were reviewed, revealing 458 (1...
June 26, 2018: Oral Diseases
Atsushi Iwai, Fumihiko Kajii, Hidenori Tanaka, Kazuo Sasaki, Keiko Matsui, Tadashi Kawai, Shinji Kamakura
OBJECTIVE: Octacalcium phosphate (OCP) and collagen (col) composite (OCPcol) demonstrated superior bone regeneration properties, and its commercialization appears to be forthcoming. As a practical medical material for new combination products, we developed a freeze-dried composite with OCPcol and teriparatide (TPTD) (OCPcolTPTDf), and investigated its bone regenerative properties. MATERIALS AND METHODS: A disk of OCPcol was made by mixing OCP granules and atelocollagen for medical use...
June 26, 2018: Oral Diseases
Suelen Teixeira Luiz, Filipe Modolo Siqueira, Izabela Mozzer, Emanuela Carla Dos Santos, Seigo Nagashima, Ana Paula Camargo Martins, Marina Luise Viola de Azevedo, Luciana Reis Azevedo Alanis, Ana Maria Grégio Hardy, Rafaela Scariot de Moraes, Maria Cássia Ferreira Aguiar, Sérgio Aparecido Ignácio, Bruno Correia Jham, Lucia de Noronha, Aline Cristina Batista Rodrigues Johann
This study was conducted to correlate and compare the immunoexpression of sex-determining region Y-box 2 (SOX-2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control) MATERIALS AND METHODS: In this observational study, OL with low-risk (n = 34) and high- risk (n = 33) dysplasia and controls samples (n = 25) were subjected to immunohistochemical analysis for SOX-2. In the epithelium, SOX-2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted...
June 25, 2018: Oral Diseases
Shailesh M Gondivkar, Rahul R Bhowate, Amol R Gadbail, Rima S Gondivkar, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
OBJECTIVE: Oral submucous fibrosis (OSF) could have a significant impact on daily life activities of affected individuals. The objective of this study was to investigate the impacts of OSF on oral health-related quality of life (OHRQoL). MATERIALS & METHODS: A total of 206 clinically diagnosed OSF patients were recruited and subjected to the condition-specific OHRQoL-OSF instrument and global self-ratings of oral health and overall well-being. RESULTS: 'Discomfort and functional impairment' dimension was highly prevalent among patients with all stages(P<0...
June 21, 2018: Oral Diseases
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