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Oral Diseases

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https://www.readbyqxmd.com/read/28449413/sporadic-versus-syndromic-keratocysts-can-we-predict-treatment-outcome-a-review-of-102-cysts
#1
Dani Noy, Adi Rachmiel, Keidar Zar, Omri Emodi, Rafael M Nagler
OBJECTIVES: Keratocystic odontogenic tumor (KCOT) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment. SUBJECTS AND METHODS: We retrospectively reviewed 118 medical files of patients diagnosed with KCOT (by tissue biopsy before surgical treatment) with/without nevoid basal cell carcinoma syndrome (NBCCS) from 1995 to 2015. Data were recorded and analyzed statistically to determine the treatment-outcome correlation...
April 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28434191/the-effect-of-parotid-gland-sparing-imrt-on-salivary-composition-flow-rate-and-xerostomia-measures
#2
Thomas M Richards, Tara Hurley, Lorna Grove, Kevin J Harrington, Guy H Carpenter, Gordon B Proctor, Christopher M Nutting
OBJECTIVES: To describe parotid gland (PG) saliva organic and inorganic composition and flow rate changes, after curative intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) and analyse the relationship between PG saliva analytes and xerostomia measures. METHODS AND MATERIALS: Twenty-six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of IMRT by HNC subsite, provided longitudinal PG salivas. Salivary flow rate, subjective and objective xerostomia measures were prospectively collected and salivas tested for inorganic and organic analytes...
April 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28430393/invited-commentary-in-vivo-cutaneous-malignancy-diagnosis-using-mitochondrial-imaging
#3
Lindsay C Strowd
A recent study by Pouli et al. (2016) published in Science Translational Medicine used an elegant set of experiments to demonstrate the ability of mitochondrial monitoring to distinguish skin cancer cells from healthy tissue in vivo. This study reveals important implications regarding the future of real-time malignancy detection (Pouli 2016). Skin cancers represent the vast majority of human malignancy, with the current estimated incidence of 4.5 million cases per year in the United States alone (Centers for Disease Control 2017)...
April 21, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28425619/analysis-of-mutations-in-the-sos-1-gene-in-two-polish-families-with-hereditary-gingival-fibromatosis
#4
Katarzyna Gawron, Grzegorz Bereta, Zuzanna Nowakowska, Katarzyna Łazarz-Bartyzel, Jan Potempa, Maria Chomyszyn-Gajewska, Renata Górska, Paweł Plakwicz
OBJECTIVES: To establish whether two families from Malopolska and Mazovia Provinces in Poland are affected by hereditary gingival fibromatosis type 1, caused by a single-cytosine insertion in exon 21 of the Son-of-Sevenless-1 gene. MATERIAL AND METHODS: Six subjects with hereditary gingival fibromatosis and five healthy subjects were enrolled in the study. Gingival biopsies were collected during gingivectomy or tooth extraction and used for histopathological evaluation...
April 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#5
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28419664/effects-of-risk-factors-on-periodontal-disease-defined-by-calibrated-community-periodontal-index-and-loss-of-attachment-scores
#6
Chiu-Wen Su, Amy Ming-Fang Yen, Hongmin Lai, Yungling Lee, Hsiu-Hsi Chen, Sam Li-Sheng Chen
OBJECTIVES: We evaluated whether and how the effects of risk factors on periodontal disease (PD) were modified by measurement errors using community periodontal index (CPI) and loss attachment (LA) in the community{\hyphen}based survey. METHODS: A pilot validation study was performed to estimate the rates of false negative and false positive for both CPI and LA in 31 subjects from different regions using measurements from 12 well{\hyphen}trained dentists and a senior periodontist as a gold standard...
April 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28415152/oral-candida-colonization-and-oral-lichen-planus
#7
LETTER
Gian Paolo Bombeccari, Aldo Bruno Giannì, Francesco Spadari
In a well-designed clinical trial, Marable et al. has reported on the incidence of oral candidiasis in patients treated with topical steroids for oral lichen planus (OLP). (Marable et al, 2016) It has been observed that "There was no significant difference in the incidence of oral fungal infection between OLP patients treated with a preventive antimycotic therapy and those not treated prophylactically". (Marable et al, 2016) This article is protected by copyright. All rights reserved.
April 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28415132/genetic-alterations-in-mesiodens-as-revealed-by-targeted-ngs-and-gene-co-occurrence-network-analysis
#8
Young Youn Kim, Jihye Hwang, Hye-Sung Kim, Hee Jun Kwon, Sanguk Kim, Ji Hyun Lee, Jae Hoon Lee
OBJECTIVE: Mesiodens is the most common type of supernumerary tooth which includes a population prevalence of 0.15-1.9%. Alongside evidence that the condition is heritable, mutations in single genes have been reported in few human supernumerary tooth cases. Gene sequencing methods in tradition way are time-consuming and labor-intensive, whereas next generation sequencing and bioinformatics are cost-effective for large samples and target sizes. MATERIALS AND METHODS: We describe the application of a targeted next generation sequencing (NGS) and bioinformatics approach to samples from 17 mesiodens patients...
April 17, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28403570/tnf-as-marker-of-oral-candidiasis-hsv-infection-and-mucositis-onset-during-chemotherapy-in-leukemia-patients
#9
Velia Ramírez-Amador, José Gabriel Zambrano, Gabriela Anaya-Saavedra, Alejandro Zentella-Dehesa, Esther Irigoyen Camacho, N Meráz-Cruz, Sergio Ponce de León
OBJECTIVE: To assess changes in the salivary expression of IL-1α,-1β,-2,-6,-10,-17 and TNF in acute leukemia (AL) patients before and during chemotherapy, and its association with HSV infection, oral candidiasis (OC) and oral mucositis (OM) onset. METHODS: Cohort study in AL patients >15 years starting induction chemotherapy at a Mexican oncological center (2013-2014). Oral lesions (OLs) onset was assessed during follow-up, and saliva was obtained at baseline, at visit 2 (days 4-12) and at visit 3 (days 13-21) after chemotherapy; treated with a protease inhibitor and stored at -70°C...
April 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28383789/salivary-microbiome-of-an-urban-indian-cohort-and-patterns-linked-to-subclinical-inflammation
#10
Aneesha Acharya, Yuki Chan, Supriya Kheur, Mohit Kheur, D Gopalakrishnan, R M Watt, Nikos Mattheos
OBJECTIVE: To profile salivary microbiomes of an urban-living, healthy Indian cohort and explore associations with proinflammatory status. METHODS: 51 clinically healthy Indian subjects' salivary microbiomes were analyzed using 16S rRNA Illumina MiSeq sequencing. Community distribution was compared with salivary data from the Human Microbiome Project (HMP). Indian subjects were clustered using microbiome based 'partitioning along medoids' (PAM) and relationships of interleukin 1 beta levels with community composition were analyzed...
April 6, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28376251/tissue-regeneration-in-dentistry-can-salamanders-provide-insight
#11
Fadi Sader, Jean-François Denis, Stéphane Roy
The ability to regenerate damaged tissues would be of tremendous benefit for medicine and dentistry. Unfortunately, humans are unable to regenerate tissues such teeth, fingers or to repair injured spinal cord. With an aging population, health problems are more prominent and dentistry is no exception as loss of bone tissue in the orofacial sphere from periodontal disease is on the rise. Humans can repair oral soft tissues exceptionally well, however hard tissues, like bone and teeth, are devoid of the ability to repair well or at all...
April 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28346730/cheese-supplemented-with-probiotics-reduced-the-candida-levels-in-denture-wearers-rct
#12
Tatiana Yuriko Miyazima, Karin Hitomi Ishikawa, Marcia Pinto Alves Mayer, Susana Marta Isay Saad, Atlas Edson Moleros Nakamae
OBJETIVES: The access to probiotics should be facilitated in order to encourage their usage. We evaluated the effect of consumption of two experimental probiotic-containing cheese on the oral colonization of Candida in denture wearers. METHODS: Sixty denture wearers harboring oral Candida were randomly allocated in groups who received cheese supplemented with Lactobacillus acidophilus NCFM (T1) or Lactobacillus rhamnosus Lr-32 (T2), daily for 8 weeks, and a control group (C) who received a control cheese...
March 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28326656/skin-cancer-diagnosed-using-artificial-intelligence-on-clinical-images
#13
I van der Waal
No abstract text is available yet for this article.
March 22, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28326646/effect-of-tempol-on-the-prevention-of-irradiation-induced-mucositis-in-miniature-pigs
#14
L Hu, Y Wang, A P Cotrim, Z Zhu, R Gao, C Zheng, C M Goldsmith, L Jin, C Zhang, J B Mitchell, B J Baum, S Wang
OBJECTIVE: The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development. METHODS AND MATERIALS: Minipigs were irradiated with 6 Gy for five consecutive days targeting the entire oral cavity. To prevent radiation damage, minipigs were treated with 30 mg kg(-1) Tempol 10 min before irradiation (n = 4), while the radiation-alone group was similarly injected with saline (n = 4)...
March 22, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28321958/e-cigarettes-and-oral-health-a-balanced-viewpoint
#15
LETTER
Richard Holliday, Ralf Kist, Linda Bauld, Philip M Preshaw
The topic of e-cigarettes and oral health is of utmost importance and we were pleased to see this addressed by a recent review that was published in Oral Diseases (Javed et al., 2017). However, we would like to raise several concerns with this review. This article is protected by copyright. All rights reserved.
March 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28295873/mutational-signatures-in-oral-cancer-indicate-a-complex-role-for-tobacco-smoke-carcinogens
#16
G Bradley, M A Magalhaes, M Hyrcza
No abstract text is available yet for this article.
March 13, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28258662/a-novel-gja1-mutation-in-oculodentodigital-dysplasia-with-extensive-loss-of-enamel
#17
T Porntaveetus, C Srichomthong, A Ohazama, K Suphapeetiporn, V Shotelersuk
OBJECTIVE: To characterize clinical features and identify genetic causes of a patient with oculodentodigital dysplasia (ODDD). SUBJECTS AND METHODS: Clinical, dental, radiological features were obtained. DNA was collected from an affected Thai family. Whole-exome sequencing was employed to identify the disease-causing mutation causing ODDD. The presence of the identified variant was confirmed by Sanger sequencing. RESULTS: The proband suffered with extensive enamel hypoplasia, polysyndactyly and clinodactyly of the 3rd-5th fingers, microphthalmia, and unique facial characteristics of ODDD...
March 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28258602/a-fatter-way-to-metastasize
#18
W A Yeudall, L Shahoumi
No abstract text is available yet for this article.
March 4, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28248452/dna-methylation-pattern-of-apoptosis-related-genes-in-ameloblastoma
#19
Sfs Costa, N B Pereira, Kma Pereira, K Campos, W H de Castro, M G Diniz, C C Gomes, R S Gomez
OBJECTIVES: DNA methylation is an important mechanism of gene control expression, and it has been poorly addressed in odontogenic tumours. On this basis, we aimed to assess the methylation pattern of 22 apoptosis-related genes in solid ameloblastomas. MATERIALS AND METHODS: Ameloblastoma fresh samples (n = 10) and dental follicles (n = 8) were included in the study. The percentage fraction of methylated and unmethylated DNA promoter of 22 apoptosis-related genes was determined using enzymatic restriction digestion and quantitative real-time PCR (qPCR) array...
March 1, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28248443/iron-overload-induces-apoptosis-of-murine-preosteoblast-cells-via-ros-and-inhibition-of-akt-pathway
#20
J-Y Ke, W-J Cen, X-Z Zhou, Y-R Li, W-D Kong, J-W Jiang
OBJECTIVE: This study investigates the inhibitory effect of iron overload on MC3T3-E1 cells and its molecular mechanism. METHODS: MC3T3-E1 cells were grown under different concentrations of FAC (ferric ammonium citrate), and the WST-8 assay was used to investigate the proliferation of cells following FAC with or without deferasirox. DCFH-DA fluorescence probe was applied to detect the cellular reactive oxygen species (ROS) level. The apoptotic cells were analyzed with Annexin V-FITC/PI and the Hoechst 33258 nuclear staining assay...
March 1, 2017: Oral Diseases
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