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International Journal of Biochemistry & Cell Biology

Xing-Bo Mo, Long-Fei Wu, Xiao-Ming Cai, Zai-Xiang Tang, Xin Lu, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
The aim of this study was to construct DNA methylation-lncRNA-mRNA interaction trios in peripheral blood mononuclear cells. We first conducted eQTL analyses using genome-wide methylation, lncRNA and mRNA expression data from 43 Chinese females. Next, causal inference test (CIT) was used to detect the lncRNA mediation effects on methylation and mRNA. Methylation-lncRNA cis-eQTL analysis identified 11 significant cis-methylation-lncRNA pairs. Combined with the results from the next lncRNA-mRNA eQTL and methylation-mRNA eQTL analyses, the 11 significant pairs and their corresponding 11,204 target e-mRNAs formed 12,245 trios...
September 15, 2018: International Journal of Biochemistry & Cell Biology
Lang He, Kang Liu, Xiaoshan Wang, Hong Chen, Jin Zhou, Xun Wu, Tao Liu, Yongxue Yang, Xuemei Yang, Dandan Cui, Guiqin Song, Jun Wang, Jianguo Lei
No abstract text is available yet for this article.
September 11, 2018: International Journal of Biochemistry & Cell Biology
Yanan Zhu, Yihui Li, Chengting Dai, Lu Sun, Lianghui You, Wei De, Ning Wang, Yuanyuan Chen, Qingxin Yuan
LncRNAs have been reported to maintain islet function and are associated with the development of diabetes. Here, we investigated Lincpint biological functions in mouse pancreatic β cells both in vivo and in vitro. We observed that Lincpint was highly expressed in BALB/c mouse islets and downregulated in db/db mouse islets by using qRT-PCR. Lincpint could be regulated by different concentrations of glucose in MIN6 cells. MTT and flow cytometry showed that silencing Lincpint expression in vitro increased cell apoptosis...
September 7, 2018: International Journal of Biochemistry & Cell Biology
Haopeng Zhang, Jiaren Liu, Guodong Li, Jiufeng Wei, Hongsheng Chen, Chunpeng Zhang, Jinlu Zhao, Yunfeng Wang, Shuwei Dang, Xinglong Li, Xuan Fang, Lianxin Liu, Ming Liu
The red raspberry (Rubus idaeus L.) is a common fruit worldwide and its extract has been found to inhibit the growth of many types of tumors, mainly because it is rich in bioactive phytochemicals. However, the mechanism underlying its anticancer activity in hepatocellular carcinoma (HCC) is not well understood. Herein, the aim of this study was to determine the effects of red raspberry phytochemicals on the proliferation of hepatocellular carcinoma cells and to elucidate its biochemical and molecular targets...
September 5, 2018: International Journal of Biochemistry & Cell Biology
Prabhodh S Abbineni, Jens R Coorssen
Docking, priming, and membrane fusion of secretory vesicles (i.e. regulated exocytosis) requires lipids and proteins. Sphingolipids, in particular, sphingosine and sphingosine-1-phosphate, have been implicated in the modulation of exocytosis. However, the specific exocytotic steps that sphingolipids modulate and the enzymes that regulate sphingolipid concentrations on native secretory vesicle membranes remain unknown. Here we use tightly coupled functional and molecular analyses of fusion-ready cell surface complexes and cortical vesicles isolated from oocytes to assess the role of sphingolipids in the late, Ca2+ -triggered steps of exocytosis...
September 5, 2018: International Journal of Biochemistry & Cell Biology
Alice Bourgeois, Junichi Omura, Karima Habbout, Sebastien Bonnet, Olivier Boucherat
Pulmonary arterial hypertension (PAH) encompasses a group of clinical entities characterized by sustained vasoconstriction and progressive vascular remodeling that act in concert to elevate pulmonary vascular resistance. The current treatments for PAH are mainly dedicated to target the process of vasoconstriction and do not offer a cure. There is now accumulating evidence that expansion of pulmonary artery cells due to increased proliferation and apoptotic evasion is a key pathological component of vascular remodeling that occurs in PAH...
September 3, 2018: International Journal of Biochemistry & Cell Biology
Na Zhang, Yahui Zhou, Qingxin Yuan, Yao Gao, Yan Wang, Xingyun Wang, Xianwei Cui, Pengfei Xu, Chenbo Ji, Xirong Guo, Yu Zeng, Nan Gu, Lianghui You
T2DM is a global health problem that seriously lowers the quality of life and insulin resistance makes a considerable contribution to the pathophysiology of T2DM. Long noncoding RNAs (lncRNAs) have emerged as important regulators in glucose and lipid metabolism. However, comprehensive analysis of lncRNAs in db/db mice skeletal muscle and their potential roles involved in skeletal muscle insulin resistance (IR) remains poorly characterized. Here, we identified 331 lncRNAs, 172 upregulated and 159 downregulated (|fold change|>2, q<0...
September 1, 2018: International Journal of Biochemistry & Cell Biology
Yun-Xiao Zhou, Wei Zhao, Li-Wei Mao, Yan-Li Wang, Li-Qun Xia, Min Cao, Jie Shen, Jun Chen
Accumulating evidence suggested that tumor-associated macrophages played crucial roles in the progression of endometrial cancer. The aim of this study was to determine the role of lncRNA NIFK-AS1 in M2-like polarization of macrophages and further to investigate the effect of NIFK-AS1 modulating macrophage polarization on the proliferation, migration and invasion of endometrial cancer cells. Human peripheral blood mononuclear cells and tumor-associated macrophages were isolated from healthy volunteers and endometrial cancer patients, respectively...
August 31, 2018: International Journal of Biochemistry & Cell Biology
Xiangbing Wu, Rongyan Wang, Jiantong Jiao, Song Li, Jun Yu, Zhiguo Yin, Leilei Zhou, Zhongjian Gong
Oral leukoplakia (OL) is the most common premalignancy in the oral cavity. The objective of this study was to investigate the biological role of transglutaminase 3 (TGM3) in malignant transformation of OL and its clinical value for predicting oral squamous cell carcinoma (OSCC) risk in patients with OL. Immunohistochemistry was used to measure TGM3 expression in OL samples from 98 patients. Patient clinicopathological and follow-up data were analyzed. The TGM3 biological role in OL cells was investigated in gain-of-function and loss-of-function assays, and the TGM3 downregulated mechanism in OLs was characterized...
August 30, 2018: International Journal of Biochemistry & Cell Biology
Ping Fan, Bo Wang, Zibo Meng, Jingyuan Zhao, Xin Jin
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. However, the mechanism underlying the tumorigenesis of HCC is still unclear. Improper recruitment of Pescadillo homologue 1 (PES1) can lead to tumorigenesis in multiple cancer types, such as gastric cancer and colon cancer. Here, we reported that PES1 was upregulated and associated with a poor prognosis in HCC specimens. Next, we found that PES1 promoted the growth of HCC in vivo and in vitro. Furthermore, we showed that the knockdown of PES1 decreased glycolysis via altering the gene expression of GLUT1, PKM2, ENO1, FBP1, and PCK1, which are related to glucose metabolism in HCC cells...
August 29, 2018: International Journal of Biochemistry & Cell Biology
Davood Bashash, Ava Safaroghli-Azar, Samaneh Bayati, Elham Razani, Atieh Pourbagheri-Sigaroodi, Arshia Gharehbaghian, Majid Momeny, Maryam Sanjadi, Mostafa Rezaie-Tavirani, Seyed H Ghaffari
While a batch of efforts are fastened on synthesizing the novel targeted anti-cancer agents, recent investigations have achieved a breakthrough in identifying a favorable anti-tumor activity for some supportive drugs, which their safety have been confirmed thus far. The results of the present study highlighted the efficacy of Aprepitant, an oral antagonist of the neurokinin-1 receptor (NK1R), against both APL (NB4) and pre-B ALL (Nalm-6) cell lines; however, a differential sensitivity pattern was found in these cells...
August 23, 2018: International Journal of Biochemistry & Cell Biology
Markéta Šašinková, Aleš Holoubek, Petra Otevřelová, Kateřina Kuželová, Barbora Brodská
C-terminal mutations of the nucleolar protein nucleophosmin (NPM) are the most frequent genetic aberration detected in acute myeloid leukemia (AML) with normal karyotype. The mutations cause aberrant cytoplasmic localization of NPM and lead to loss of functions associated with NPM nucleolar localization, e.g. in ribosome biogenesis or DNA-damage repair. NPM has many interaction partners and some of them were proved to interact also with the mutated form (NPMmut) and due to this interaction thereby to be withdrawn from their site of action...
August 18, 2018: International Journal of Biochemistry & Cell Biology
Nicolás Chiarante, María C García Vior, Osvaldo Rey, Julieta Marino, Leonor P Roguin
We have previously reported that the phototoxic action of the lipophilic phthalocyanine Pc9 (2,9(10),16(17),23(24) tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)) encapsulated into poloxamine micelles is related to the induction of an apoptotic response in murine colon CT26 carcinoma cells. In the present study, we explored the intracellular signals contributing to the resulting apoptotic death. We found that Pc9-T1107 arrests cell cycle progression immediately after irradiation promoting then an apoptotic response...
August 18, 2018: International Journal of Biochemistry & Cell Biology
Razak Hussain, Mushtaq Ahmed, Tabreiz Ahmad Khan, Yusuf Akhter
Cytochrome P450s are involved in a variety of monooxygenation reactions that require electron transfer from one redox partner to the other. We have recently shown the catalytic mechanism of a cytochrome P450 monooxygenase like protein (encoded by tri11 gene) that catalyzes the hydroxylation of 12,13-epoxytrichothec-9-ene (EPT) to produce trichodermol in the trichothecene biosynthetic pathway of trichodermin and harzianum A in Trichoderma brevicompactum [J Biol Inorg Chem. 22(8):1197-1209. doi:
August 18, 2018: International Journal of Biochemistry & Cell Biology
Gege Yan, Lai Zhang, Chao Feng, Rui Gong, Elina Idiiatullina, Qihe Huang, Mingyu He, Shuyuan Guo, Fan Yang, Yuan Li, Fengzhi Ding, Wenya Ma, Valentin Pavlov, Zhenbo Han, Zhiguo Wang, Chaoqian Xu, Benzhi Cai, Ye Yuan, Lei Yang
The light emitting diodes (LEDs) irradiation has been demonstrated to be potential therapeutic strategies for several diseases. However, the blue LED effects remain largely unknown in colorectal cancer (CRC), which is a major cause of morbidity and mortality throughout the world. In this study, we determined the effects of blue LED irradiation, the maximal light emission at 470 nm in wavelength, in human CRC cell lines SW620 and HT29. The cells were irradiated with blue LED light for 0 J/cm2 , 72 J/cm2 , 144 J/cm2 , 216 J/cm2 and 288 J/cm2 respectively...
August 17, 2018: International Journal of Biochemistry & Cell Biology
Yongliang Jiang, Xuanfen Zhou, Ruicheng Hu, Aiguo Dai
Endothelial-to-mesenchymal transition (EndMT), which is characterized by increased proliferation, migration and invasion of endothelial cells, increased expression of mesenchymal markers and reduced expression of endothelial markers, has been reported to be closely related to the pathogenesis of several diseases, including pulmonary fibrosis. Resistin-like molecule-β (RELM-β), also known as "found in inflammatory zone 2" (FIIZ2), plays an essential role in airway remodeling and pulmonary fibrosis; however, its role and mechanism in EndMT remain unclear...
August 15, 2018: International Journal of Biochemistry & Cell Biology
Finnur Freyr Eiriksson, Ottar Rolfsson, Helga M Ogmundsdottir, Gudmundur G Haraldsson, Margret Thorsteinsdottir, Skarphedinn Halldorsson
Epithelial to mesenchymal transition (EMT) is a developmental event characterized by phenotypic switching from a polarized epithelial phenotype to an unpolarized mesenchymal phenotype. Changes to plasma membrane function accompany EMT yet the differences in lipid composition of cells that have undergone EMT are relatively unexplored. To address this the lipidome of two cell models of EMT in breast epithelial tissue, D492 and HMLE, were analyzed by untargeted LC-MS. Detected masses were identified and their abundance was compared through multivariate statistical analysis...
August 13, 2018: International Journal of Biochemistry & Cell Biology
Baoning Qi, Chuandao Shi, Juanjuan Meng, Shouzhu Xu, Juntian Liu
Excessive ethanol (EtOH) intake affects cognitive function and leads to permanent learning and memory deficits. EtOH-induced neuroinflammation plays an important role in EtOH neurotoxicity. Studies have shown that EtOH activates microglia and induces an inflammatory response. Resveratrol (Rsv) is a natural polyphenol found in a wide variety of plants and fruits, and produces the neuroprotective and anti-inflammatory effects in the central nervous system. However, effect of Rsv on EtOH-induced neuroinflammation is still unknown...
August 11, 2018: International Journal of Biochemistry & Cell Biology
Wei Xie, Yan Zhang, Yuan He, Kunchi Zhang, Guoqing Wan, Yanjuan Huang, Zhaoli Zhou, Gang Huang, Jin Wang
Triple negative breast cancer (TNBC) is one of the most difficult malignancy to treat due to a lack of targeted therapy. Studies have demonstrated that the activation of Wnt/β-catenin signaling was preferentially found in TNBC. Frizzled-7 (Fzd7), one of the Wnt receptors, was significantly up-regulated in TNBC and modulated TNBC tumorigenesis through the Wnt signaling pathway, indicating Fzd7 is a biomarker and a potential therapeutic target for TNBC. Here, we designed a recombinant soluble peptide fragment (rhFzd7) to antagonize Fzd7 by competitively binding with Wnt ligands...
August 7, 2018: International Journal of Biochemistry & Cell Biology
Hong Zeng, Tao Li, Jun Tian, Li-Li Zhang
Verticillium wilt, caused by Verticillium dahliae, is a cancer of cotton which affects cotton quality and yield in China. In our previous study, a novel anti-Verticillium dahliae protein TUBP1 was obtained from Bacillus axarquiensis. Then, we have systematically studied the anti-V. dahliae activity and the pore formation action of TUBP1 protein on V. dahliae membrane. In present study, we provide detailed whether TUBP1 protein induced mitochondrial damaged and mitochondria-mediated apoptotic cell death in V...
August 3, 2018: International Journal of Biochemistry & Cell Biology
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