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Journal of Trace Elements in Medicine and Biology

Emel Canaz, Metin Kilinc, Hamide Sayar, Gurkan Kiran, Eser Ozyurek
OBJECTIVE: Wide variation exists in ovarian cancer incidence rates suggesting the importance of environmental factors. Due to increasing environmental pollution, trace elements and heavy metals have drawn attention in studies defining the etiology of cancer, but scant data is available for ovarian cancer. Our aim was to compare the tissue concentrations of lead, selenium and nickel in epithelial ovarian cancer, borderline tumor and healthy ovarian tissues. METHODS: The levels of lead, selenium and nickel were estimated using atomic absorption spectrophotometry in formalin-fixed paraffin-embedded tissue samples...
May 17, 2017: Journal of Trace Elements in Medicine and Biology
Soo-Hwaun Kim, Young-Wook Lim, Kyung-Su Park, Ji-Yeon Yang
Environmental exposure to cadmium can cause renal damage. Foods containing cadmium are generally regarded as the main environmental sources of human exposure to cadmium. In this study, foods that are ingested in large amounts, including rice and other types of food with a high concentration of cadmium, were investigated to determine the correlation between the foods' cadmium content and biomarkers. The datasets required for this study, including blood cadmium concentration, biomarker concentration, and data on the amount of consumption by food item, were obtained from KNHNES...
April 29, 2017: Journal of Trace Elements in Medicine and Biology
Nermin Berik, Ekrem Cem Çankırılıgil, Güzin Gül
In this research, one of the most promising scallop species, smooth scallop (Flexopecten glaber) was studied. According to our findings, smooth scallop has beneficial micro and macro minerals, fat and carbohydrate just before the spawning. While the ratios protein, ash and water decreased from autumn to summer, ratio of crude fat increased till reproduction season in late spring and decreased in summer (P<0.05). In digestive glands, aluminum, bromine, cadmium, calcium, chromium, copper, iron, manganese, nickel, and zinc were detected more compared to adductor muscles (P<0...
July 2017: Journal of Trace Elements in Medicine and Biology
Siavash Fazelian, Mohamad H Rouhani, Sahar Saraf Bank, Reza Amani
INTRODUCTION: polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Some vitamins and mineral can play role in improvement of PCOS. Chromium (Cr) is an essential element in glucose and insulin homeostasis. However, findings are not consistent regarding PCOS improvement. Therefore, the purpose of this paper was to assess the effect of Cr supplementation in PCOS that have not yet fully been elucidated. METHODS: We searched ISI Web of Science, MEDLINE (1966 to June 2016), Google Scholar databases and Proquest and identified eligible papers and extracted the following terms: total testosterone, DHEAS, insulin sensitivity, fasting glucose, fasting insulin, OGTT 1h glucose, OGTT 2h glucose (mg/dL), LH (mIU/mL), FSH, DHEAS, ferriman-Galwey score (FG score)...
July 2017: Journal of Trace Elements in Medicine and Biology
Keaton S Nahan, Kyle B Walsh, Opeolu Adeoye, Julio A Landero-Figueroa
Stroke, a major cause of disability and mortality, affects someone in the United States every 40s. Stroke biomarkers, including those that could be used as a blood test for diagnosis of stroke, have been particularly elusive. We performed a double blind study to identify human plasma biomarkers for the diagnosis of stroke, including acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). We utilized a three-track approach based on the total metal profile, the metal cofactor levels among metalloproteins, and the identification of stroke-related metalloproteins...
July 2017: Journal of Trace Elements in Medicine and Biology
Beata Janasik, Anna Zawisza, Beata Malachowska, Wojciech Fendler, Magdalena Stanislawska, Renata Kuras, Wojciech Wasowicz
The interaction between arsenic (As) and selenium (Se) has been one of the most extensively studied. The antagonism between As and Se suggests that low Se status plays an important role in aggravating arsenic toxicity in diseases development. The objective of this study was to assess the Se contents in biological samples of inorganic As exposed workers (n=61) and in non-exposed subjects (n=52). Median (Me) total arsenic concentration in urine of exposed workers was 21.83μg/g creat. (interquartile range (IQR) 15...
July 2017: Journal of Trace Elements in Medicine and Biology
Varikasuvu Seshadri Reddy, Suman Bukke, Naveen Dutt, Puneet Rana, Arun Kumar Pandey
BACKGROUND: Available studies in the literature on the selenium levels in Alzheimer's disease (AD) are inconsistent with some studies reporting its decrease in the circulation, while others reported an increase or no change as compared to controls. AIM: The objective of this study was to perform a meta-analysis of circulatory (plasma/serum and blood), erythrocyte and cerebrospinal fluid (CSF) selenium levels in AD compared controls. We also performed a meta-analysis of the correlation coefficients (r) to demonstrate the associations between selenium and glutathione peroxidase (GPx) in AD patients...
July 2017: Journal of Trace Elements in Medicine and Biology
Chenggui Xu, Guihua Lu, Qinglang Li, Juhong Zhang, Zhibin Huang, Xiuren Gao
BACKGROUND: A high-fat diet is a major risk factor for coronary heart diseases. Matrix metalloprotease (MMP) expression is changed in many cardiovascular diseases. Selenium, which is an important trace element in animals, has a close relationship with cardiovascular diseases. The TGFβ1/Smad signalling pathway is ubiquitous in diverse tissues and cells, and it is also associated with the occurrence and development of cardiovascular diseases. Therefore, in this study, we aimed to determine selenium's effect on lipid metabolism, atherosclerotic plaque formation, and MMP2 expression, as well as the underlying functional mechanism...
July 2017: Journal of Trace Elements in Medicine and Biology
J Chwiej, A Patulska, A Skoczen, K Matusiak, K Janeczko, M Ciarach, R Simon, Z Setkowicz
In this paper the influence of two different ketogenic diets (KDs) on the seizure-evoked elemental anomalies of hippocampal formation was examined. To achieve this purpose normal and pilocarpine treated rats previously fed with one of the two high fat and carbohydrate restricted diets were compared with animals on standard laboratory diet. The ketogenic ratios of the examined KDs were equal to 5:1 (KD1) and 9:1 (KD2). KD1 and standard diet fed animals presented similar patterns of seizure-evoked elemental changes in hippocampal formation...
July 2017: Journal of Trace Elements in Medicine and Biology
Peter D Merrill, Steve B Ampah, Ka He, Nicole J Rembert, John Brockman, Dawn Kleindorfer, Leslie A McClure
The disparities in stroke mortality between blacks and whites, as well as the increased stroke mortality in the "stroke belt" have long been noted. The reasons for these disparities have yet to be fully explained. The association between trace element status and cardiovascular diseases, including stroke, has been suggested as a possible contributor to the disparities in stroke mortality but has not been fully explored. The purpose of this study is to investigate distributions of four trace elements (arsenic, mercury, magnesium, and selenium) in the environment in relation to stroke risk...
July 2017: Journal of Trace Elements in Medicine and Biology
Elena Bargagli, Federico Lavorini, Massimo Pistolesi, Elisabetta Rosi, Antje Prasse, Emilia Rota, Luca Voltolini
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a poor prognosis and an undefined etiopathogenesis. Oxidative stress contributes to alveolar injury and fibrosis development and, because transition metals are essential to the functioning of most proteins involved in redox reactions, a better knowledge of metal concentrations and metabolism in the respiratory system of IPF patients may provide a valuable complementary approach to prevent and manage a disease which is often misdiagnosed or diagnosed in later stages...
July 2017: Journal of Trace Elements in Medicine and Biology
N Pichel, M Vivar
Iodine content in drinking water at the Saharawi refugee camps was analysed to assess the controversy in the origin of the prevalence of goitre among this population. A review on the iodine presence in drinking water reported in the literature was conducted, along with international standards and guidelines for iodine intake and iodine concentration in drinking water were also consulted. Chinese legislation was taken as the reference standard to evaluate the iodine concentration in water as adequate (10-150μg/L) or not (high iodine >150μg/L and iodine excess goitre >300μg/L)...
July 2017: Journal of Trace Elements in Medicine and Biology
Leslie M Klevay
No abstract text is available yet for this article.
July 2017: Journal of Trace Elements in Medicine and Biology
Abdullah A Saeed, Mansur A Sandhu, Muhammad S Khilji, Muhammad S Yousaf, Habib U Rehman, Zafar I Tanvir, Tanveer Ahmad
The study was conducted to ascertain the effects of dietary chromium chloride (CrCl3·6H2O) supplementation on mineral interaction in blood serum, leg muscles and bones of broilers at 35(th) day of age. For this purpose, ninety male broiler chicks were divided into three groups. One served as control (group I) while, the other two groups were supplemented with CrCl3 (group II-12.5mg/Kg feed; group III-25mg/Kg feed) from 12 to 28days of age. In serum, Cr concentration remained non-significant however, Zn, and K concentrations decreased (P<0...
July 2017: Journal of Trace Elements in Medicine and Biology
David A Geier, Janet K Kern, Mark R Geier
BACKGROUND: Thimerosal is an organic-mercury (Hg)-containing compound (49.55% Hg by weight) historically added to many multi-dose vials of vaccine as a preservative and still added to some vaccines today. Concerns about the toxic effects from Thimerosal-containing childhood vaccines and the risk of an atypical autism diagnosis were evaluated in this study. METHODS: A hypothesis-testing, prospective longitudinal, case-control study assessed exposure to Hg from Thimerosal-containing hepatitis B vaccines (TM-HepB) among cases diagnosed with atypical autism (n=164) and controls (n=15,216)...
July 2017: Journal of Trace Elements in Medicine and Biology
Siamak Asri-Rezaei, Bahram Dalir-Naghadeh, Ali Nazarizadeh, Zahra Noori-Sabzikar
The cardio-protective effects of zinc oxide nanoparticles (Zn NPs) against diabetes-induced cardiopathy were evaluated and compared with zinc sulfate (ZnSO4). A total of 120 Wistar rats were randomly categorized as healthy and diabetic groups. Then, the 2 groups were classified in 5 subgroups. The animals received oral supplementations containing different Zn NP (ie, doses of 1, 3, and 10mg/kg) and ZnSO4 (30mg/kg) concentrations over 8 weeks. Blood and cardiac tissue samples were collected in the different time intervals and subjected to biochemical and histopathological analysis...
July 2017: Journal of Trace Elements in Medicine and Biology
Nouf Abdulkareem Omer Alkharashi, Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan, Ali A Alshatwi
Cadmium (Cd) is a well-known heavy metal that causes environmental pollution and human health problems. Several studies attempted to assess Cd toxicity in vitro and in vivo. However, the systemic profile of cadmium toxicity has not been studied well. In the present study, we assessed the toxicity of Cd on human peripheral blood lymphocytes and monocytes and gene expression, using a system toxicological approach. Cd effect on cell viability and morphology were analyzed by MTT assay and AO/EB staining respectively...
July 2017: Journal of Trace Elements in Medicine and Biology
Marta López-Alonso, Paloma Carbajales, Marta Miranda, Victor Pereira
Previous studies of intensively reared cattle in NW Spain have reported significantly higher copper (Cu) accumulation in the liver in Holstein-Friesian (HF) animals than in Galician Blonde (GB) or GBxHF crosses when receiving a diet supplemented at the maximum Cu concentrations allowed in the EU legislation (35mg/kg). The present study aimed to evaluate whether this difference is due to the pattern of subcellular accumulation of Cu in the liver. For this purpose, liver samples from 10 GB, 9 HF and 10 GBxHF young bulls were analysed to determine the content of metallothionein (MT) and Cu and zinc (Zn) (in the liver (Cu-liver and Zn-liver) and bound to metallothionein (Cu-MT and Zn-MT))...
July 2017: Journal of Trace Elements in Medicine and Biology
J Prejac, V Višnjević, A A Skalny, A R Grabeklis, N Mimica, B Momčilović
Strontium (Sr) is a trace element that closely resembles calcium metabolism. At the present time there is no available long-term biological indicator tissue for assessing the human Sr nutritional status. Here we have presented a novel concept on how to assess the Sr nutritional status by studying the frequency distribution properties of hair Sr ((Sr)H) concentration. In this prospective, observational, cross-sectional, and exploratory epidemiological study, we analyzed (Sr)H in 311 apparently healthy adult Croatians (123 men, 188 women)...
July 2017: Journal of Trace Elements in Medicine and Biology
Ewa Tomaszewska, Siemowit Muszyński, Katarzyna Ognik, Piotr Dobrowolski, Małgorzata Kwiecień, Jerzy Juśkiewicz, Dariusz Chocyk, Michał Świetlicki, Tomasz Blicharski, Bożena Gładyszewska
Copper is required for normal functioning of all basic biochemical and physiological processes in the body. The objective of this study was to compare the effect of two different chemical forms (carbonate and nanoparticles) of Cu administered in feed mixtures to growing rats on bone geometric and structural parameters as well as material characteristics in a rat model. For this purpose, five experimental treatments were used to evaluate the effects of different levels of Cu applied in the diet as a mineral mixture (the standard dose of 6...
July 2017: Journal of Trace Elements in Medicine and Biology
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