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Journal of Trace Elements in Medicine and Biology

Vilma Liaugaudaite, Narseta Mickuviene, Nijole Raskauskiene, Rima Naginiene, Leo Sher
Suicide is a major public health concern affecting both the society and family life. There are data indicating that higher level lithium intake with drinking water is associated with lower suicide rate. This pilot study examined the relationship between lithium levels in drinking water and suicide rates in Lithuania. Twenty-two samples from public drinking water systems were taken in 9 cities of Lithuania. The lithium concentration in these samples was determined by inductively coupled plasma mass spectrometry (ICP-MS)...
March 24, 2017: Journal of Trace Elements in Medicine and Biology
Tong Lin, Tiebing Liu, Yucheng Lin, Lailai Yan, Zhongxue Chen, Jingyu Wang
The etiology and pathophysiology of schizophrenia (SCZ) remain obscure. This study explored the associations between SCZ risk and serum levels of 39 macro and trace elements (MTE). A 1:1 matched case-control study was conducted among 114 schizophrenia patients and 114 healthy controls matched by age, sex and region. Blood samples were collected to determine the concentrations of 39 MTE by ICP-AES and ICP-MS. Both supervised learning methods and classical statistical testing were used to uncover the difference of MTE levels between cases and controls...
March 24, 2017: Journal of Trace Elements in Medicine and Biology
B Sundararajan, B D Ranjitha Kumari
The Aedes aegypti L. mosquito transmits dengue and yellow fever, which cause millions of death every year. Dengue is a mosquito-borne viral disease that has rapidly spread worldwide particularly in countries with tropical and subtropical climates areas. The present study denotes a simple and eco-friendly biosynthesis of gold nanoparticles using Artemisia vulgaris L. leaf extract as reducing agent. The synthesized gold nanoparticles were characterized by UV-Visible Spectroscopy, X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS), Zeta Potential (ZP), Transmission Electron Microscopy (TEM) and Energy Dispersive X-ray Spectroscopy (EDX)...
March 18, 2017: Journal of Trace Elements in Medicine and Biology
K Maduray, J Moodley, C Soobramoney, R Moodley, T Naicker
Pre-eclampsia is a hypertensive disorder that is associated with adverse maternal and perinatal outcomes. It has been proposed that specific trace and macro elements associated with antioxidant activities may also play a contributory role in aetiology of pre-eclampsia. The aim of this study was to measure the concentrations of thirteen different elements in hair and serum samples from women with a diagnosis of pre-eclampsia and compare them with normotensive controls. Venous blood and pubic hair samples were collected from forty-three pre-eclamptic and twenty-three normotensive pregnant women...
March 9, 2017: Journal of Trace Elements in Medicine and Biology
Dag G Ellingsen, Maxim Chashchin, Balazs Berlinger, Vladimir Fedorov, Valery Chashchin, Yngvar Thomassen
BACKGROUND: Welders are exposed to a number of metallic elements during work. Bioaccessability, that is important for element uptake, has been little studied. This study addresses bioaccessability and uptake of chromium (Cr), molybdenum (Mo), tungsten (W) and vanadium (V) among welders. METHODS: Bioaccessability of Cr, Mo, V and W was studied in airborne particulate matter collected by personal sampling of the workroom air among shipyard welders by using the lung lining fluid simulant Hatch solution...
May 2017: Journal of Trace Elements in Medicine and Biology
Anica Simić, Ailin Falkmo Hansen, Bjørn Olav Åsvold, Pål Richard Romundstad, Kristian Midthjell, Tore Syversen, Trond Peder Flaten
Several epidemiological studies have indicated that a number of trace elements may play a role in type 2 diabetes (T2D). We investigated the association between prevalent T2D and the concentrations of 25 trace elements in whole blood, and the relationships between T2D duration and blood levels of the trace elements that we found to be related to T2D prevalence. In this population based case-control study, 267 patients with self-reported T2D and 609 controls (frequency matched), were selected from the third Nord-Trøndelag Health Survey...
May 2017: Journal of Trace Elements in Medicine and Biology
Mohammad Reza Khaksar, Mahban Rahimifard, Maryam Baeeri, Faheem Maqbool, Mona Navaei-Nigjeh, Shokoufeh Hassani, Shermineh Moeini-Nodeh, Abbas Kebriaeezadeh, Mohammad Abdollahi
Diazinon is a kind of organophosphorus (OP) compound that is broadly used against different species of insects and pests. Oxidative stress can occur at very early stages of diazinon exposure and the pancreas is one of the main target organs for toxicity by diazinon. The aim of this study was to evaluate the protective effects of cerium oxide nanoparticles (CeO2 NPs) and yttrium oxide nanoparticles (Y2O3 NPs) against the pancreatic damage from sub-acute exposure of diazinon. Diazinon at a dose of 70mg/kg/day was given through gavage to rats once a day...
May 2017: Journal of Trace Elements in Medicine and Biology
Dijana Djurović, Branka Milisavljević, Boban Mugoša, Nikoleta Lugonja, Srđan Miletić, Snežana Spasić, Miroslav Vrvić
Normal supply of zinc to the newborn via milk is essential for normal development. Using ICP-OES, we analyzed changes in the level of Zn in milk and infant serum in the neonatal period (Day 1 and Day 28 post partum) and at 6 months after delivery, in the cohort of 60 mothers and exclusively breastfed babies. Zn level in the serum showed increase (significant at 6 months) during this period (mg/mL): Day 1: 0.52±0.12; Day 28: 0.59±0.19; 6 months: 0.68±0.28. The concentration of Zn in the milk showed an opposite (decreasing) trend during the follow up: Day 1: 4...
May 2017: Journal of Trace Elements in Medicine and Biology
Kun Tian, Cong-Cong He, Hui-Nan Xu, Yu-Xiang Wang, Hong-Gang Wang, Di An, Bin Heng, Wei Pang, Yu-Gang Jiang, Yan-Qiang Liu
In the present study, cultured rat primary neurons were exposed to a medium containing N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), a specific cell membrane-permeant Zn(2+) chelator, to establish a model of free Zn(2+) deficiency in neurons. The effects of TPEN-mediated free Zn(2+) ion reduction on neuronal viability and on the performance of voltage-gated sodium channels (VGSCs) and potassium channels (Kvs) were assessed. Free Zn(2+) deficiency 1) markedly reduced the neuronal survival rate, 2) reduced the peak amplitude of INa, 3) shifted the INa activation curve towards depolarization, 4) modulated the sensitivity of sodium channel voltage-dependent inactivation to a depolarization voltage, and 5) increased the time course of recovery from sodium channel inactivation...
May 2017: Journal of Trace Elements in Medicine and Biology
Patrick L Day, Steven J Eckdahl, Joseph J Maleszewski, Thomas C Wright, David L Murray
OBJECTIVE: Chromium, cobalt, and vanadium are used in metallic joint prosthesis. Case studies have associated elevated heart tissue cobalt concentrations with myocardial injury. To document the long term heart metal ion concentrations, a validated inductively coupled plasma mass spectroscopy (ICP-MS) method was needed. METHOD: The method utilized a closed-vessel microwave digestion system to digest the samples. An ICP-MS method utilizing Universal Cell Technology was used to determine our target analyte concentrations...
May 2017: Journal of Trace Elements in Medicine and Biology
Jasna Jablan, Suzana Inić, Hagen Stosnach, Maja Ortner Hadžiabdić, Lovorka Vujić, Ana-Marija Domijan
The aim of the present study was to explore impact of endurance exercise on urinary level of minerals and trace elements as well as on some oxidative stress and biochemical parameters. Urine samples were collected from participants (n=21) of mountain ultra-marathon race (53km; Medvednica, Zagreb, Croatia), before (baseline value), immediately after, 12h and 24h after the race. In urine samples level of minerals (Ca, P, K and Na) and trace elements (Se, Zn, Mn, Cu, Fe and Co) were assessed using the bench top Total reflection X-ray Fluorescence (TXRF) spectrometer...
May 2017: Journal of Trace Elements in Medicine and Biology
Geir Bjørklund, Jan Aaseth, Anatoly V Skalny, Joanna Suliburska, Margarita G Skalnaya, Alexandr A Nikonorov, Alexey A Tinkov
Iron (Fe) deficiency is considered as the most common nutritional deficiency. Iron deficiency is usually associated with low Fe intake, blood loss, diseases, poor absorption, gastrointestinal parasites, or increased physiological demands as in pregnancy. Nutritional Fe deficiency is usually treated with Fe tablets, sometimes with Fe-containing multimineral tablets. Trace element interactions may have a significant impact on Fe status. Existing data demonstrate a tight interaction between manganese (Mn) and Fe, especially in Fe-deficient state...
May 2017: Journal of Trace Elements in Medicine and Biology
Peter Heitland, Martin Blohm, Christian Breuer, Florian Brinkert, Eike Gert Achilles, Ieva Pukite, Helmut Dietrich Köster
ICP-MS and HPLC-ICP-MS were applied for diagnosis and therapeutic monitoring in a severe intoxication with a liquid containing hexavalent chromium (Cr(VI)) and inorganic arsenic (iAs). In this rare case a liver transplantation of was considered as the only chance of survival. We developed and applied methods for the determination of Cr(VI) in erythrocytes and total chromium (Cr) and arsenic (As) in blood, plasma, urine and liver tissue by ICP-MS. Exposure to iAs was diagnosed by determination of iAs species and their metabolites in urine by anion exchange HPLC-ICP-MS...
May 2017: Journal of Trace Elements in Medicine and Biology
Hakan Doneray, Elif Olcaysu, Abdulkadir Yildirim, Ayse Ozden
The change in breast milk zinc (Zn) concentration in a feeding period during lactation may affect neonatal weight gain. The aim of this study was to determine how to change the Zn concentrations in breast milk during a feeding period in early and late lactation periods and identify the relationship between the differences in the Zn levels in breast milk during lactation and neonatal weight gain. Breast milk was collected in the early and late lactation periods with samples being obtained before (foremilk) and after (hindmilk) a feeding period...
May 2017: Journal of Trace Elements in Medicine and Biology
Zhonglei Li, Jun Tan, Lei Shao, Xiaojing Dong, Richard D Ye, Daijie Chen
Inducing production of damaging reactive oxygen species (ROS) is an important criterion to distinguish the bactericidal antibiotics from bacteriostatic antibiotics. Selenoenzymes were generally recognized to be a powerful antioxidant capable of scavenging free radicals, protecting the cells from the harmful effects of ROS. Therefore, the present study was carried out to investigate the selenium (Se)-mediated protection in reversing antibiotic sensitivity and the role of selenoenzymes in alleviating the negative effects of oxidative stress...
May 2017: Journal of Trace Elements in Medicine and Biology
Jesus Antonio Alvarado Huayhuaz, Hector Aguilar Vitorino, Othon Souto Campos, Silvia Helena Pires Serrano, Telma Mary Kaneko, Breno Pannia Espósito
Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me=Al(3+) and Ga(3+)) were synthesized and characterized by mass spectroscopy and cyclic voltammetry...
May 2017: Journal of Trace Elements in Medicine and Biology
Domenico Lapenna, Giuliano Ciofani, Gabriele Obletter
Iron-induced human LDL oxidation, which is relevant to atherosclerosis, has not yet been properly investigated. We addressed such issue using iron(II) and (III) basically in the presence of phosphates, which are present in vivo and influence iron oxidative properties, at pH 4.5 and 7.4, representative, respectively, of the lysosomal and plasma environment. In 10mM phosphate buffered saline (PBS), iron(II) induces substantial LDL oxidation at pH 4.5 at low micromolar concentrations, while at pH 7.4 has low oxidative effects; iron(III) promotes small LDL oxidation only at pH 4...
May 2017: Journal of Trace Elements in Medicine and Biology
Piotr Kosior, Maciej Dobrzyński, Mariusz Korczyński, Katarzyna Herman, Agnieszka Czajczyńska-Waszkiewicz, Małgorzata Kowalczyk-Zając, Dagmara Piesiak-Pańczyszyn, Katarzyna Fita, Maciej Janeczek
The intensity of the cariostatic activity of fluoride ions can be attributed to their multidirectional influence on the caries process. They are an irreplaceable factor that helps sustain mineral balance of dental tissues, simultaneously demonstrating antibacterial properties. As a consequence, many manufacturers of fissure sealants include fluoride ions in their products. The aim of this in vitro study was to determine long-term fluoride release from four fissure sealants (Conseal F, Fissurit FX, Delton Fs+, Admira Seal)...
May 2017: Journal of Trace Elements in Medicine and Biology
Shamshad Karatela, Janis Paterson, Neil I Ward
OBJECTIVE: Very little is known about the relationship between postnatal methylmercury concentrations (via toenails as bioindicator) and behavioural characteristics of Pacific Island children living in New Zealand. The aim of this study was to explore the association between total mercury exposure and different domains of behavioural problems in Pacific children. MATERIALS AND METHODS: A sample of nine-year-old Pacific Island children resident in Auckland, New Zealand participated in this study...
May 2017: Journal of Trace Elements in Medicine and Biology
Zeynep Ozturk, Gizem Esra Genc, Saadet Gumuslu
Thalassaemia major (TM) is a hereditary blood disease characterised by reduced or absent production of beta globin chains. Erythrocyte transfusions are given to raise the haemoglobin level in patients with thalassaemia major. However, transfusions have been related to increased risk of iron overload and tissue damage related to excess iron. Both elevated oxidative stress due to iron overload and increased hemolysis lead to over utilisation of minerals required for antioxidant enzymes activities. Iron chelators have been used to prevent iron overload in thalassaemia major patients, but these chelators have the possibility of removing minerals from the body...
May 2017: Journal of Trace Elements in Medicine and Biology
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