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Journal of Trace Elements in Medicine and Biology

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https://www.readbyqxmd.com/read/30366679/7-chloro-4-phenylselanyl-quinoline-prevents-dopamine-depletion-in-a-drosophila-melanogaster-model-of-parkinson-s-like-disease
#1
Shanda de Freitas Couto, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Marcia Rósula Poetini, Franciane Cabral Pinheiro, Elize Aparecida Santos Musachio, Luana Barreto Meichtry, Manoela do Sacramento, Diego Alves, Diogo La Rosa Novo, Márcia Foster Mesko, Marina Prigol
Neurodegeneration in Parkinson's disease appears to be caused by multiple factors, including oxidative damage and an increase in acetylcholinesterase expression that can culminate in loss of dopaminergic neurons. A selenium-containing quinoline derivative, 7-chloro-4-(phenylselanyl) quinoline (4-PSQ), shows important pharmacological actions mainly attributed to its antioxidant and anticholinesterase properties. Thus, this study investigated the neuroprotective effect of 4-PSQ in a model of Parkinson's-like disease induced by rotenone (ROT) in Drosophila melanogaster and verified whether these effects are related to selenium levels...
October 15, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30269760/chromium-picolinate-reduces-morphine-dependence-in-rats-while-increasing-brain-serotonin-levels
#2
Diana Ciubotariu, Mihai Nechifor, Gabriel Dimitriu
Chromium is an essential trace element with anti-diabetic and anti-depressant effect; the latter is considered related to chromium properties of increasing brain serotonin. Cr3+ salts were shown to improve some forced swimming-parameters and to induce rewarding effects, which are additive to those of morphine, but Cr effect on addictive processes has not been tested. AIM: The present study aimed to assess chromium picolinate (CrPi) influence on morphine-dependence in rats. MATHERIAL AND METHODS: We used five groups of 10 rats...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30269759/analysis-of-metal-content-in-soils-near-abandoned-mines-of-bashkir-trans-urals-and-in-the-hair-of-children-living-in-this-territory
#3
I N Semenova, Yu S Rafikova, R F Khasanova, Ya T Suyundukov
The aim of this study was to investigate the metal content in the hair of children living near abandoned nonferrous metal mines located in the rural settlements Tubinsk, Ishmurzino and Semenovsk the South Urals (Russia), and in the soils obtained from the same area. The hair and soils samples were examined for the presence of the following metals: copper (Cu), zinc (Zn), iron (Fe), cobalt (Co), nickel (Ni), manganese (Mn), lead (Pb) and cadmium (Cd). The results of this study showed that soil from this territory contained an increased level of Cu, Fe, Zn, Mn, Pb, Cd, exceeding the maximum permissible concentration (MPC) 38...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30269758/evaluation-of-the-accuracy-of-exchangeable-copper-and-relative-exchangeable-copper-rec-in-a-mouse-model-of-wilson-s-disease
#4
Sophie Heissat, Amélie Harel, Khémary Um, Anne-Sophie Brunet, Valérie Hervieu, Olivier Guillaud, Jerome Dumortier, Alain Lachaux, Elisabeth Mintz, Muriel Bost
Wilson's disease (WD) is caused by mutations in the ATP7B gene responsible for a toxic copper overload mainly in the liver and the central nervous system. Phenotypic heterogeneity may challenge the diagnostic confirmation. Exchangeable copper (CuEXC) has recently been proposed as a new marker of WD, and its ratio to the total serum copper (Cus), Relative Exchangeable Copper (REC = CuEXC/Cus), as a diagnostic marker. This study aimed to investigate whether this could be confirmed in Atp7b-/- mice, an engineered WD animal model...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262322/reversing-the-adverse-biochemical-effects-in-lead-intoxicated-rats-by-n-n-bis-1-2-didehydro-1-hydroxy-2-thioxopyrid-4-yl-carbonyl-l-lysine
#5
Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak
N,N`-Bis[(1,2-didehydro-1-hydroxy-2-thioxopyrid-4-yl)-carbonyl]- L-lysine (HTPL) is a novel newly synthesized compound intended to be used for the chelation of lead in intoxicated animals. Subchronic lead intoxication experiments were carried out on Wistar male rats; these rats were intoxicated with lead and then treated with HTPL. Results were compared with those obtained with known compounds used for lead chelation therapy, such as disodium ethylnediaminetetraacetic acid (CaNa2 EDTA) and meso-2,3-dimercaptosuccininc acid (DMSA), using different routes of administration...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262321/respiratory-complex-ii-in-mitochondrial-dysfunction-mediated-cytotoxicity-insight-from-cadmium
#6
Elena A Belyaeva
In the present work we studied action of several inhibitors of respiratory complex II (CII) of mitochondrial electron transport chain, namely malonate and thenoyltrifluoroacetone (TTFA) on Cd2+ -induced toxicity and cell mortality, using two rat cell lines, pheochromocytoma PC12 and ascites hepatoma AS-30D and isolated rat liver mitochondria (RLM). It was shown that malonate, an endogenous competitive inhibitor of dicarboxylate-binding site of CII, restored in part RLM respiratory function disturbed by Cd2+ ...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262320/analysis-of-aluminum-minerals-and-trace-elements-in-the-milk-samples-from-lactating-mothers-in-hamadan-iran
#7
Masoumeh Taravati Javad, Aliasghar Vahidinia, Fateme Samiee, Jomana Elaridi, Mostafa Leili, Javad Faradmal, Alireza Rahmani
The present cross-sectional study is aimed at analyzing the breast milk of lactating mothers in Hamadan, Iran for aluminum and several minerals and trace elements. Ten governmental health care centers were utilized to facilitate collection of breast milk samples. The breast milk samples were collected at 1, 2, 6, 7, and 12 months postpartum from one hundred healthy lactating women, who delivered full-term newborns. Detection of sodium (Na), zinc (Zn), calcium (Ca), iron (Fe), copper (Cu), magnesium (Mg) and aluminum (Al) levels was conducted with the use of Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262319/sub-acute-intravenous-exposure-to-fe-2-o-3-nanoparticles-does-not-alter-cognitive-performances-and-catecholamine-levels-but-slightly-disrupts-plasma-iron-level-and-brain-iron-content-in-rats
#8
Dalel Askri, Souhir Ouni, Said Galai, Benoit Chovelon, Josiane Arnaud, Sylvia G Lehmann, Mohsen Sakly, Michel Sève, Salem Amara
Engineered nanomaterials are used in various applications due to their particular properties. Among them, Iron Oxide Nanoparticles (Fe2 O3 -NPs) are used in Biomedicine as theranostic agents i.e. contrast agents in Magnetic Resonance Imaging and cancer treatment. With the increasing production and use of these Fe2 O3 -NPs, there is an evident raise of Fe2 O3 -NPs exposure and subsequently a higher risk of adverse outcomes for the environment and Human. In the present paper, we investigated the effects of an intravenous daily Fe2 O3 -NPs exposure on Wistar rat for one week...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262318/aqueous-humor-selenium-level-and-open-angle-glaucoma
#9
Anselm G M Jünemann, Bernhard Michalke, Marianna Lucio, Anwar Chaudhri, Ursula Schlötzer-Schrehardt, Robert Rejdak, Marek Rękas, Bettina Hohberger
PURPOSE: Selenium supplementation was seen to be linked to glaucoma disease in a previous study (Lillico A. JE, Reid M et al. (2002) Selenium Supplementation and Risk of Glaucoma in the NPC trial University of Arizona, Tucson, AZ., Arizona Cancer Center). As aqueous humor levels of selenium seemed to be associated with primary open-angle glaucoma (POAG), the aim of this study was to analyze concentrations of selenium in aqueous humor samples of patients with POAG and pseudoexfoliation glaucoma (PEXG) in comparison to normal samples...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262317/manganese-induced-changes-in-glandular-trichomes-density-and-essential-oils-production-of-mentha-aquatica-l-at-different-growth-stages
#10
Mehrdad Nazari, Fatemeh Zarinkamar, Bahram Mohammad Soltani, Vahid Niknam
Production and accumulation of essential oils in plants are influenced by intrinsic and environmental factors. Here, we attempted to elucidate the effect of manganese (Mn) supply on the density of glandular trichomes and the production of essential oils in Mentha aquatica (water mint; syn. Mentha hirsuta Huds.) at the different growth stages. To this aim, plants were treated with 100 μM of Mn (supplied as MnSO4 ·H2 O) at early and late vegetative stages of growth. Then, the control and treated plants were harvested, and biochemical, morphological and molecular analyses indicated that Mn supply has affected M...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262316/effects-of-boron-containing-compounds-on-cardiovascular-disease-risk-factors-a-review
#11
REVIEW
Ionuţ Donoiu, Constantin Militaru, Oana Obleagă, John M Hunter, Johny Neamţu, Andrei Biţă, Ion Romulus Scorei, Otilia Constantina Rogoveanu
Boron is considered to be a biological trace element but there is substantial and growing support for it to be classified as an essential nutrient for animals and humans, depending on its speciation. Boron-containing compounds have been reported to play an important role in biological systems. Although the exact biochemical functions of boron-containing compounds have not yet been fully elucidated, previous studies suggest an active involvement of these molecules in the mediation of inflammation and oxidative stress...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262315/profile-of-three-boron-containing-compounds-on-the-body-weight-metabolism-and-inflammatory-markers-of-diabetic-rats
#12
Yessica López-Cabrera, Emily L Castillo-García, José A Altamirano-Espino, Teresa Pérez-Capistran, Eunice D Farfán-García, José G Trujillo-Ferrara, Marvin A Soriano-Ursúa
It has been reported that boron induces changes in carbohydrate and lipid metabolism, body weight and inflammatory processes. This is relevant to the biomedical field due to the requirement for developing therapeutic tools with potential application in metabolic disorders affecting humankind. However, most of the reported data from both humans and animals were obtained after boron was administered as borax or boric acid. In this work, we determined the effects of boric, cyclohexylboronic (CHB) and phenylboronic (PBA) acids (10 mg/kg of body weight/daily for two weeks) on the body weight, metabolism and inflammatory markers in the blood of control, fat-feeding and experimental diabetic rats...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262314/selenium-and-copper-interaction-at-supra-nutritional-level-affecting-blood-parameters-including-immune-response-against-p-multocida-antigen-in-murrah-buffalo-bubalus-bubalis-calves
#13
Vishal Mudgal, Anil Kumar Garg, Ram Sharan Dass, Mayank Rawat
Minerals play important role in the diet of an animal. Bio-availability of minerals largely gets affected by absolute as well as the relative amount of each mineral present in the diet of an animal. Copper and selenium are two such an essential elements affect utilization of each other in the gastrointestinal tract. The present study elucidates the utilization of copper and selenium at supra-nutritional levels (higher than nutritional requirements). Male Murrah buffalo (Bubalus bubalis) calves (n = 10, 8-9 months, 111...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262313/calcium-magnesium-zinc-and-lead-concentrations-in-the-structures-forming-knee-joint-in-patients-with-osteoarthritis%C3%A2
#14
Danuta I Kosik-Bogacka, Natalia Lanocha-Arendarczyk, Karolina Kot, Pawel Zietek, Maciej Karaczun, Adam Prokopowicz, Patrycja Kupnicka, Zaneta Ciosek
The aim of the study was to investigate the relationships between the concentrations of calcium (Ca), magnesium (Mg), zinc (Zn), and lead (Pb) in cartilage, anterior cruciate ligament, and meniscus samples obtained following knee joint surgery in patients with osteoarthritis in northwestern Poland.‬ Furthermore, we examined the relationships between the concentrations of these metals in the studied parts of the knee joint and the influences of gender, age, BMI and hypertension. We found significantly higher concentrations of Ca, Mg, and Zn in the cartilage of men than in women and a significantly higher Pb concentration in the meniscus of the men...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262312/spinocerebellar-ataxia-an-inborn-error-of-copper-metabolism
#15
LETTER
Leslie M Klevay
No abstract text is available yet for this article.
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262311/trace-elements-content-in-semen-and-their-interactions-with-sperm-quality-and-redox-status-in-freshwater-fish-cyprinus-carpio-a-correlation-study
#16
Anton Kovacik, Filip Tirpak, Marian Tomka, Michal Miskeje, Eva Tvrda, Julius Arvay, Jaroslav Andreji, Tomas Slanina, Michal Gabor, Lukas Hleba, Martin Fik, Tomas Jambor, Miroslava Cisarova, Peter Massanyi
Objective of the present study was to investigate interactions between trace elements content and RedOx status, as well as sperm quality parameters (motility features, DNA fragmentation) in fish spermatozoa in natural conditions. Reproductively mature male freshwater fish (n = 16) of Cyprinus carpio breed were used in the study. Trace elements content was determined in fish milt samples by inductively-coupled plasma optical emission spectrometry (ICP-OES) and by cold-vapor atomic absorption spectroscopy (CV-AAS)...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262310/effects-of-non-digestive-polymers-used-in-iron-encapsulation-on-calcium-and-iron-apparent-absorption-in-rats-fed-by-infant-formula
#17
Masoumeh Moslemi, Hedayat Hosseini, Tirang Reza Neyestani, Naeimeh Akramzadeh, Ramin Mazaheri Nezhad Fard
Iron deficiency anemia is a common problem of all ages in developed and developing countries. Various strategies are used by governments and industries to solve this problem. One of these strategies is iron fortification. In the present study, novel iron microcapsules were designed without any changes in their effects on other ingredients in infant milk formulas. Resistant starch-pectin-iron and pectin-iron microparticles were added to infant powdered milk models. Furthermore, animal studies were carried out...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262309/concentration-of-chromium-in-whole-blood-and-erythrocytes-showed-different-relationships-with-serum-apolipoprotein-levels-in-cr-vi-exposed-subjects
#18
Huimin Feng, Feizai Ha, Guiping Hu, Yonghua Wu, Shanfa Yu, Zhang Ji, Weiyue Feng, Tiancheng Wang, Guang Jia
OBJECTIVE: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism. METHODS: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins. RESULTS: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262308/zinc-uptake-in-fish-intestinal-epithelial-model-rtgutgc-impact-of-media-ion-composition-and-methionine-chelation
#19
P Antony Jesu Prabhu, T Stewart, M Silva, H Amlund, R Ørnsrud, E-J Lock, R Waagbo, C Hogstrand
Apical uptake of zinc as ionic Zn(II) or as Zn-methionine (Zn-Met) was studied in RTgutGC cell line in vitro under media compositions mirroring the gut luminal ionic concentration of freshwater (FW) and seawater (SW) acclimated salmonids. Viability of the RTgutGC cells exposed to experimental media preparations showed a time-dependent decrease in SW treated cells, with the effect being significant at 48 h (P < 0.01), but not at 12 h or 24 h. Half effective concentration of Zn exposure over 12 h (EC50 , in μM) was not differentially affected by media composition (FW, 59...
December 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/30262307/influence-of-dietary-zinc-on-the-claw-and-interdigital-skin-of-sheep
#20
Benjamin U Bauer, Christof Rapp, Christoph K W Mülling, Jessica Meissner, Charlotte Vogel, Esther Humann-Ziehank
Claw diseases like interdigital dermatitis and footrot threaten sheep health and are major welfare issues. Several studies mainly done in cattle suggested that zinc (Zn) supplementation may improve claw integrity. However, Zn supplements may differ markedly regarding Zn bioavailability. Zn bound to single amino acids has been shown to be more bioavailable than inorganic Zn sources. The aim of this study was to determine the effect of different Zn supplements on the integrity of the claw and interdigital skin of healthy sheep...
December 2018: Journal of Trace Elements in Medicine and Biology
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