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Journal of Trace Elements in Medicine and Biology

A V Syroeshkin, N V Antipova, A V Zlatska, I A Zlatskiy, M D Skylska, T V Grebennikova, V V Goncharuk
Here we show the dependence of the unicellular biosensor S.ambigua lifespan on the water D/H isotopic composition. This dependence is bell-shaped with descents both in case of deficiency or excess of deuterium in water. The influence of the water D/H isotopic composition on the cell culture proliferative potential and colony forming efficiency in vitro was tested on the human dermal fibroblasts. We observed that the deuterium depleted water stimulates cell colony formation at the early passages. The dynamics of the cell doubling index in the deuterium depleted water-based growth medium showed higher proliferation potential compared to the water with normal isotopic composition...
May 14, 2018: Journal of Trace Elements in Medicine and Biology
Ross Wenzel, Derek Major, Karly Hesp, Philip Doble
Regulating authorities in the racing industry have restricted the administration of potentially performance enhancing cobalt salts to horses. There are severe penalties for trainers presenting horses with elevated urine cobalt concentrations, and compliance is ensured via analysis of total urinary cobalt at thresholds of 100 μg/L. When cobalt is present as part of the cobalamin molecule it is not considered performance enhancing. This paper demonstrates that a horse can excrete a significant proportion of a commercially available vitamin B12 injection in urine without metabolic modification...
May 9, 2018: Journal of Trace Elements in Medicine and Biology
Anatoly V Skalny, Natalia V Simashkova, Anastasia A Skalnaya, Tatiana P Klyushnik, Irina V Zhegalova, Andrei R Grabeklis, Margarita G Skalnaya, Alexey A Tinkov
The objective of the present study was to estimate the association between brain inflammatory markers and serum trace element levels as assessed by inductively coupled plasma mass spectrometry at NexION 300D. Leukocyte elastase (LE), α1-proteinase inhibitor (α1-PI) activity, anti-nerve growth factor-antibodies (anti-NGF-Ab), and anti-myelin basic protein-antibodies (anti-MBP-Ab) levels were assessed as inflammatory markers. The obtained data demonstrate that the increase in LE and α1-PI activity is associated with higher serum Cr and Cu levels, respectively...
April 27, 2018: Journal of Trace Elements in Medicine and Biology
Irem Uluisik, Huseyin Caglar Karakaya, Ahmet Koc
No abstract text is available yet for this article.
April 27, 2018: Journal of Trace Elements in Medicine and Biology
David E B Fleming, Stephen R Bennett, Christopher J Frederickson
A variety of adverse health effects have been identified as resulting from zinc deficiency. Zinc supplementation may therefore be indicated for certain individuals or populations. A rapid and straightforward means of assessing zinc status in humans would be of considerable medical benefit. In this study, the feasibility of measuring zinc levels in human fingernails or toenails using a portable x-ray fluorescence technique was assessed. Whole nail models (or phantoms) were constructed from resin, and dosed with various concentrations of zinc...
April 26, 2018: Journal of Trace Elements in Medicine and Biology
Samir A Anuj, Harsukh P Gajera, Darshna G Hirpara, Baljibhai A Golakiya
With the threat of the growing number of bacteria resistant to antibiotics, the re-emergence of previously deadly infections and the emergence of new infections, there is an urgent need for novel therapeutic agent. Silver in the nano form, which is being used increasingly as antibacterial agents, may extend its antibacterial application to emerging and re-emerging multidrug-resistant pathogens, the main cause of nosocomial diseases worldwide. In the present study, a completely bottom up method to prepare green nano-silver was used...
April 24, 2018: Journal of Trace Elements in Medicine and Biology
Márcia Cristina Sales, Larissa Praça de Oliveira, Natalia Louise de Araújo Cabral, Sara Estéfani Soares de Sousa, Maria das Graças Almeida, Telma Maria Araújo Moura Lemos, Clélia de Oliveira Lyra, Kenio Costa de Lima, Karine Cavalcanti Mauricio Sena-Evangelista, Lucia de Fatima Campos Pedrosa
Changes in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes...
April 24, 2018: Journal of Trace Elements in Medicine and Biology
Yordanka Gluhcheva, Kalina Kamenova, Petar Dorkov, Yulia Lobanova, Margarita Skalnaya, Juliana Ivanova
Cadmium (Cd) is an environmental pollutant shown to induce multi organ dysfunction. In this study we present novel data about the effects of meso-2,3-dimercaptosuccinic acid (DMSA), monensin and salinomycin on the concentration of Cd in skeletal muscles of mice exposed to Cd (II) acetate treatment for 14 days. The impact of Cd and the chelating agents on the endogenous concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorous (P), selenium (Se) and zinc (Zn) was also investigated. Subacute exposure of mice to Cd (II) acetate resulted in a significant accumulation of the toxic metal ion in the skeletal muscles compared to the untreated controls...
April 20, 2018: Journal of Trace Elements in Medicine and Biology
Yang Liu, Wei Zhang, Jiating Zhao, Xiaoying Lin, Jiamei Liu, Liwei Cui, Yuxi Gao, Tian-Lan Zhang, Bai Li, Yu-Feng Li
Selenium (Se) has been found to promote weight gain, decrease hepatic damage, but redistribute mercury (Hg) in brains and livers in methylmercury (MeHg)-poisoned rats. The aims of the present work were to examine the effects of Se on the levels of Hg in serum and the role of serum selenoproteins in binding with Hg in MeHg-poisoned rats. The concentration of Se, Hg and MeHg were studied using ICP-MS and CVAFS. The Hg- and Se-binding selenoproteins were separated and quantified using affinity chromatography with post-column isotope dilution analysis using both enriched 78 Se and 199 Hg...
April 18, 2018: Journal of Trace Elements in Medicine and Biology
Danijela Joksimović, Ana Castelli, Ana Perošević, Dijana Djurović, Slavka Stanković
The concentrations of six trace metals, cadmium (Cd), copper (Cu), chromium (Cr), lead (Pb), zinc (Zn) and mercury (Hg) were determined in the soft tissues of the mussel Mytilus galloprovincialis and bottom sediments collected from the coastal area of Boka Kotorska Bay (Montenegrin coast). The mussels and sediment samples were collected at three sites along the Boka Kotorska Bay from the autumn of 2014 to the winter of 2016. The concentrations (mg/kg dw) of these metals in the mussel samples ranged from 1.01 to 2...
April 17, 2018: Journal of Trace Elements in Medicine and Biology
Joanna I Lachowicz, Miriam Crespo-Alonso, Claudia Caltagirone, Giancarla Alberti, Raffaela Biesuz, James O Orton, Valeria M Nurchi
This paper presents an easy, fast and economic synthesis of chelating agents for medical, environmental and analytical applications, and the evaluation of the stability of their complexes with Fe3+ and Al3+ . Complex formation equilibria with Cu2+ and Zn2+ metal ions were also studied to evaluate if the chelating agents can perturb the homeostatic equilibria of these essential metal ions. Effective chelating agents for metal ions, in addition to their well-known medical uses, find an increasing number of applications in environmental remediation, agricultural applications (supplying essential elements in an easily available form), and in analytical chemistry as colorimetric reagents...
April 16, 2018: Journal of Trace Elements in Medicine and Biology
Nural Pastacı Özsobacı, Dilek Düzgün Ergün, Sinem Durmuş, Matem Tunçdemir, Hafize Uzun, Remise Gelişgen, Derviş Özçelik
There is a widespread use of 2.4 GHz electromagnetic radiation emitting devices especially in communication and education. Recent studies show the adverse effects of electromagnetic fields (EMF) such as oxidative stress, cellular damage and apoptosis on tissues. Selenium (Se) has an antioxidant properties by inhibiting oxidative damage being within the structure of antioxidant enzymes like glutathione peroxidase (GSH-Px) and it has also regulatory function for cell cycle and apoptosis. The aim of this study was to investigate the effect of Se on 2...
April 13, 2018: Journal of Trace Elements in Medicine and Biology
Berislav Momčilović, Juraj Prejac, Anatoly Viktorovich Skalny, Ninoslav Mimica
The principles and practice of assessing the human body nutritional status or its environmental exposure through hair bioelement analysis are presented; herein the term "bioelements" is used as a common denominator for the major elements, trace elements and ultra-trace elements that are found in the human body. The accumulation of bioelements in the hair followed the statistical Power Law and the resulting sigmoid curve can be zoned into five regions in the ascending order of abundance (Low, Marginal, Adequate, High, and Excessive)...
April 12, 2018: Journal of Trace Elements in Medicine and Biology
Ana Perošević, Danijela Joksimović, Dijana Đurović, Ivana Milašević, Milena Radomirović, Slavka Stanković
In order to assess human health risks via consumption of potentially toxic mussels, the concentrations of Al, Ba, Cd, Co, Cr, Cu, Fe, Li, Mn, Ni, Pb, Sr, Zn and Hg were studied in Mytilus galloprovincialis collected from the coastal area of Montenegro. By two approaches for the human health risk assessment (HHRA), considering oral reference doses by the United States Environmental Protection Agency (US EPA) and provisional tolerable intakes by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), it has been revealed that despite the fact that trace element levels do not exceed the defined limits for mussels, they can be limiting factors for the mussel consumption...
March 28, 2018: Journal of Trace Elements in Medicine and Biology
Alvaro Perez, Pamela Rojas, Fernando Carrasco, Karen Basfi-Fer, Francisco Perez-Bravo, Juana Codoceo, Jorge Inostroza, Jose E Galgani, L Anne Gilmore, Manuel Ruz
BACKGROUND/OBJECTIVE: Interest in healthy properties of food and nutrients as co-adjuvant in type-2 diabetes therapy has increased in recent years. Zinc supplementation trials have shown improvements in glycemic control in these patients, although it seems dependent on zinc status of the individuals. The objective of this study was to evaluate the relationship between zinc nutritional status and glucose homeostasis in patients with type-2 diabetes. SUBJECTS/METHODS: Eighty patients with well controlled type-2 diabetes were recruited and clinical, anthropometric and dietary evaluations were performed...
March 26, 2018: Journal of Trace Elements in Medicine and Biology
Julia Krabbe, André Esser, Stephanie Kanzler, Till Braunschweig, Svetlana Kintsler, Jan Spillner, Thomas Schröder, Sebastian Kalverkamp, Galina Balakirski, Benjamin Gerhards, Annette D Rieg, Thomas Kraus, Peter Brand, Christian Martin
Recently, the pro-inflammatory effects of metal inert gas brazing welding fumes containing zinc and copper have been demonstrated in humans. Here, murine, rat and human precision cut lung slices (PCLS) were incubated in welding fume containing media with 0.1, 1, 10 and 100 μg/ml for 24 or 48 h. 24 h incubation were determined either by incubation for the total time or for only 6 h followed by a 18 h post-incubation phase. Cytotoxicity, proliferation and DNA repair rates, and cytokine levels were determined...
March 10, 2018: Journal of Trace Elements in Medicine and Biology
Michaela Falk, Aksel Bernhoft, Tore Framstad, Brit Salbu, Helene Wisløff, Trond M Kortner, Anja B Kristoffersen, Marianne Oropeza-Moe
The study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
Philippe Collery
Many experimental models demonstrated that inorganic and organic selenium (Se) compounds may have an anticancer activity. However, large clinical studies failed to demonstrate that Se supplementations may prevent the outcome of cancers. Moreover, there are few randomized trials in cancer patients and there is not yet any Se compound recognized as anticancer drug. There is still a need to develop new Se compounds with new strategies. For that, it may be necessary to consider that Se compounds may have a dual role, either as anti-oxidant or as pro-oxidant...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
Xue Lin, Yilin Liu, Tiantian Meng, Chunyan Xie, Xin Wu, Yulong Yin
The study was conducted to investigate the effects of different circadian calcium feeding regimes on parameters of Zn status and gene expression of circadian clock, calcium transporters and oxidative status in laying hens. In total, 180 of 41-weeks Brown Hy-line laying hens were assigned randomly into three groups, 1-CON group (Control Ca, diets contained 3.4% Ca at both 0730 and 1530 h), 2-HL group (High-low Ca, diets contained 3.6%-3.2% Ca respectively) and 3-LH group (Low-high Ca, diets contained 3.2%-3...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
Tommaso Filippini, Silvia Cilloni, Marcella Malavolti, Federica Violi, Carlotta Malagoli, Marina Tesauro, Ilaria Bottecchi, Angela Ferrari, Luciano Vescovi, Marco Vinceti
This study provides the dietary intakes of six trace elements (cadmium, chromium, copper, manganese, selenium and zinc), generally characterized by both nutritional and toxicological features depending on their exposure. Being diet the most relevant source of exposure to trace elements in non-professionally exposed subjects, we measured content of these trace elements in foods composing the typical Italian diet using inductively coupled plasma-mass spectrometry, and assessing dietary habits using a validated semi-quantitative food frequency questionnaire we eventually estimated dietary daily intake of trace elements in a Northern Italian community...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
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