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Journal of Trace Elements in Medicine and Biology

Antonietta Vilella, Daniela Belletti, Ann Katrin Sauer, Simone Hagmeyer, Tasnuva Sarowar, Martina Masoni, Natalia Stasiak, John J E Mulvihill, Barbara Ruozi, Flavio Forni, Maria Angela Vandelli, Giovanni Tosi, Michele Zoli, Andreas M Grabrucker
A local dyshomeostasis of zinc ions in the vicinity of amyloid aggregates has been proposed in Alzheimer's disease (AD) due to the sequestration of zinc in senile plaques. While an increase in zinc levels may promote the aggregation of amyloid beta (Aβ), increased brain zinc might also be beneficial rescuing some pathological alterations caused by local zinc deficiency. For example, increased Aβ degradation by metalloproteinases, and a reduction in inflammation can be hypothesized. In addition, zinc may allow a stabilization of the number of synapses in AD brains...
December 27, 2017: Journal of Trace Elements in Medicine and Biology
Robert G Tripon, Judit Oláh, Tajwar Nasir, Lajos Csincsik, Chee Lok Li, Sándor Szunyogh, Haiyan Gong, Jane M Flinn, Judit Ovádi, Imre Lengyel
Tubulin Polymerization Promoting Protein (TPPP/p25) modulates the dynamics and stability of the microtubule network by its bundling and acetylation enhancing activities that can be modulated by the binding of zinc to TPPP/p25. Its expression is essential for the differentiation of oligodendrocytes, the major constituents of the myelin sheath, and has been associated with neuronal inclusions. In this paper, evidence is provided for the expression and localization of TPPP/p25 in the zinc-rich retina and in the oligodendrocytes in the optic nerve...
December 27, 2017: Journal of Trace Elements in Medicine and Biology
Igor M Pongrac, Lada Brkić Ahmed, Hrvoje Mlinarić, Darija Domazet Jurašin, Ivan Pavičić, Ana Marija Marjanović Čermak, Mirta Milić, Srećko Gajović, Ivana Vinković Vrček
The rapid development and widespread applications of nanotechnology necessitates the design towards safe nanoparticles. Surface structure is among the most important physicochemical characteristics of metallic nanoparticles affecting their mode of action in certain biological or environmental compartments. This study aimed to investigate how different surface coatings affect the cytotoxicity and cellular uptake of silver nanoparticles (AgNPs) in murine neural stem cells (mNSCs). Different AgNPs were prepared by stabilisation with surface coatings encompassing sodium bis(2-ethylhexyl)-sulfosuccinate (AOT), cetyltrimethylammonium bromide (CTAB), poly(vinylpyrrolidone) (PVP), poly-l-lysine (PLL), and bovine serum albumin (BSA)...
December 16, 2017: Journal of Trace Elements in Medicine and Biology
Daniela Florea, Jorge Molina-López, Christer Hogstrand, Imre Lengyel, Antonio Pérez de la Cruz, Manuel Rodríguez-Elvira, Elena Planells
INTRODUCTION: Critically ill patients develop severe stress, inflammation and a clinical state that may raise the utilization and metabolic replacement of many nutrients and especially zinc, depleting their body reserves. This study was designed to assess the zinc status in critical care patients with systemic inflammatory response syndrome (SIRS), comparing them with a group of healthy people, and studying the association with expression of zinc transporters. MATERIAL AND METHODS: This investigation was a prospective, multicentre, comparative, observational and analytic study...
November 26, 2017: Journal of Trace Elements in Medicine and Biology
Muthukumar Abinaya, Baskaralingam Vaseeharan, Mani Divya, Aruna Sharmili, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Jamal M Khaled, Giovanni Benelli
In this study, a novel and effective approach was performed to synthesize ZnO nanoparticles (ZnO NPs) using the exopolysaccharides (EPS) from the probiotic strain Bacillus licheniformis Dahb1. EPS acted as reducing and stabilizing agent for the formation of EPS-ZnO NPs by co-precipitation method. Structural characterization was investigated by a surface plasma resonance centered at 375nm in UV-vis spectrum. FTIR spectrum exhibited functional groups with strong absorption peak at 3814.7-420cm-1. XRD showed the crystalline nature of EPS-ZnO NPs...
January 2018: Journal of Trace Elements in Medicine and Biology
Blanka Tariba Lovaković, Maja Lazarus, Irena Brčić Karačonji, Karlo Jurica, Tanja Živković Semren, Dražen Lušić, Nataša Brajenović, Zdenka Pelaić, Alica Pizent
The concentration of 23 major and trace elements, total phenolic content (TPC) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity were determined in nine samples of strawberry tree honey and compared to other types of unifloral honeys. The most abundant elements in strawberry tree honey were potassium, calcium, magnesium and sodium, ranging between 1276 and 2367, 95.2-154, 14.4-74.4 and 13.4-64.3mg/kg, respectively. Strawberry tree honey had generally higher TPC (range: 0.314-0.522g GA/kg) and DPPH (1...
January 2018: Journal of Trace Elements in Medicine and Biology
Katarzyna Zabłocka-Słowińska, Sylwia Płaczkowska, Anna Prescha, Konrad Pawełczyk, Irena Porębska, Monika Kosacka, Lilla Pawlik-Sobecka, Halina Grajeta
Disturbed redox status may be critical to lung cancerogenesis, however little research has been conducted on general changes in total redox status in lung cancer. Levels and activities of antioxidants, especially enzymatic ones, are related to trace element concentration. Trace element status is often disturbed in cancers, however no studies concerning the association between redox and trace element status have been performed for lung cancer. We hypothesized that disturbed redox status in lung cancer patients is partially determined by trace elements while their distribution amongst blood compartments may differ compared to healthy subjects...
January 2018: Journal of Trace Elements in Medicine and Biology
Memduh Şahin, Fahri Karayakar, Kivilcim Eren Erdogan, Firdevs Bas, Tahsin Colak
AIM: In this study, the relationship of liver tissue trace element concentrations with hepatitis B disease and the effects of several environmental factors were analysed. METHOD: The liver tissue concentrations of Al, Fe, Cd, Mn, Cr, Cu, Pb, Ni, Zn, Ag, and Co were evaluated in 92 patients with hepatitis B using the Inductively Coupled Plasma - Mass Spectrometry (ICP/MS) method in the analyses. The patients were divided into the following two groups: low-high Ishak histologic activity index (HAI) (0-6: Low Histologic Activity, 7-18: High Histologic Activity) and low-high fibrosis (FS) (Fibrosis 1,1,2 and Fibrosis 3,4,5,6)...
January 2018: Journal of Trace Elements in Medicine and Biology
Zhe Li, Xia Li, Wen Ju, Guanrui Wu, Xiaomei Yang, Xiaofeng Fu, Xibao Gao
BACKGROUND: The relationship between selenium level and impaired fasting glucose or elevated fasting serum glucose remains controversial. This study aimed to evaluate these associations in China. METHODS: This observational population study adopted a cluster sampling approach to enroll participants. Baseline information on selenium categories was tested using one-way analysis of variance and Kruskal-Wallis equality-of-populations rank tests. Multivariable logistic regression was used to investigate the association between serum selenium level and impaired fasting glucose or elevated fasting serum glucose...
January 2018: Journal of Trace Elements in Medicine and Biology
Clara Barneo-Caragol, Eduardo Martínez-Morillo, Susana Rodríguez-González, Paloma Lequerica-Fernández, Ignacio Vega-Naredo, Francisco V Álvarez Menéndez
BACKGROUND: Pregnancy brings about metabolic and oxidative changes that involve various trace elements and oxidative stress. Strontium (Sr) is a trace element scarcely studied in this context, although it has been suggested that it may play a role in the pathophysiology of preeclampsia. The main aim of this study was to evaluate Sr concentrations and oxidative status in normal pregnancy. METHODS: The study population included non-pregnant women (n=31), healthy pregnant women in the first (n=50), second (n=51) and third (n=53) trimesters of gestation, and women in postpartum period (n=31)...
January 2018: Journal of Trace Elements in Medicine and Biology
Juraj Prejac, Andrey A Skalny, Andrei R Grabeklis, Suzana Uzun, Ninoslav Mimica, Berislav Momčilović
Boron is a non-essential ubiquitous trace element in the human body. The aim of this study was to assess boron nutritional status by analyzing boron frequency distribution in the long-term biological indicator tissue of hair and the short-term biological indicator of whole blood. Hair samples were analyzed in 727 apparently healthy subjects (263 ♂ and 464 ♀) and the whole blood boron was analyzed in the random subsample of them (80 ♂ and 152 ♀). Samples were analyzed by the ICP-MS at the Center for Biotic Medicine, Moscow, Russia...
January 2018: Journal of Trace Elements in Medicine and Biology
Sigrun Henjum, Inger Aakre, Tor A Strand, Liv Elin Torheim
No abstract text is available yet for this article.
January 2018: Journal of Trace Elements in Medicine and Biology
Xiaoting Ge, Fenfen Wang, Yaoqiu Zhong, Yingnan Lv, Chao Jiang, Yanting Zhou, Defu Li, Bing Xia, Cheng Su, Hong Cheng, Yifei Ma, Feng Xiong, Yuefei Shen, Yunfeng Zou, Xiaobo Yang
Elevated exposure to manganese (Mn) has long been a public health concern. However, there is currently no consensus on the best exposure biomarker. Here we aimed to investigate the exposomic characteristics of plasma metals among Mn-exposed workers and explore the potential biomarkers of Mn exposure in the blood pool. First, total sixteen plasma metals (Calcium, Magnesium, Iron, Zinc, Copper, Selenium, Lead, Chromium, Arsenic, Manganese, Nickel, Molybdenum, Cadmium, Mercury, Thallium, and Cobalt) were determined among 40 occupationally Mn-exposed subjects...
January 2018: Journal of Trace Elements in Medicine and Biology
Na Wei, Yang-Ting Dong, Jie Deng, Ya Wang, Xiao-Lan Qi, Wen-Feng Yu, Yan Xiao, Jian-Jiang Zhou, Zhi-Zhong Guan
Expressions of N-methyl-d-aspartic acid receptors (NMDARs) in the brains of rats and primary neurons exposed to high fluoride were investigated. Sprague-Dawley rats were divided randomly into a fluorosis group (50ppm fluoride in the drinking water for 6 months) and controls (<0.5ppm fluoride) and the offspring from these rats sacrificed on postnatal days 1, 7, 14, 21 and 28. The primary cultured neurons from the hippocampus of neonatal rats were treated with 5 and 50ppm fluoride for 48h. NMDAR subunits at protein or mRNA levels were quantified by Western blotting or real-time PCR...
January 2018: Journal of Trace Elements in Medicine and Biology
Ashaki A Rouff, George A Lager, Dayana Arrue, John Jaynes
Equine enteroliths ∼1.5cm in diameter were collected from an Arabian horse in Louisville, Kentucky, United States. Scanning electron microscopy (SEM) and light microscope imaging of a sectioned enterolith showed two distinct regions of concentric growth outward from the central nidus, a small pebble. After initial growth, acidic colonic fluids permeated the stone inducing recrystallization and alteration of crystals closest to the nidus. A second growth event, when mineral crystallization was again favorable, produced an outer region of unaltered crystals at the rim...
January 2018: Journal of Trace Elements in Medicine and Biology
Brittanya A Limone, Sharon E Jacob
No abstract text is available yet for this article.
January 2018: Journal of Trace Elements in Medicine and Biology
Rosanna Squitti, Roberta Ghidoni, Ilaria Simonelli, Irena D Ivanova, Nicola Antonio Colabufo, Massimo Zuin, Luisa Benussi, Giuliano Binetti, Emanuele Cassetta, Mauro Rongioletti, Mariacristina Siotto
Abnormal handling of copper is the cause of Wilson disease (WD), a rare disorder typified by increased levels in plasma copper not-bound to ceruloplasmin (nCp-Cu, also known as 'free' copper). In Alzheimer's disease (AD), meta-analyses show that copper decreases in brain but increases in serum, due to the nCp Cu component increase. Despite the similarities, a direct comparison of copper biological status in the two diseases has never been carried out. To fill this gap, we evaluated serum copper, ceruloplasmin, nCp-Cu and Cu:Cp in 385 CE and 336 healthy controls previously investigated that were compared with 9 newly diagnosed WD patients...
January 2018: Journal of Trace Elements in Medicine and Biology
Simona Catalani, Matteo Paganelli, Maria Enrica Gilberti, Luca Rozzini, Francesco Lanfranchi, Alessandro Padovani, Pietro Apostoli
Copper (Cu), as an essential metal, plays a crucial role in biochemical reactions and in physiological regulations. Cu in plasma is mostly bound to proteins; about 65-90% of Cu is tightly binds with caeruloplasmin and the rest of Cu is loosely binds with albumin and transcuprein. A small but significant relatively "free" fraction, probably complexed with amino acids, is present at around 5% of the total concentration. We developed and validated a new method for direct measurement of free Cu in serum by ultrafiltration with AMICON®Ultra 100K device and determination with AAS...
January 2018: Journal of Trace Elements in Medicine and Biology
Maciej Lipko, Bogdan Debski
Chromium is considered a trace element which improves glucose tolerance, but mechanism accounting for this insulin-like action is not recognized. The main purpose of this study was to examine the role of reactive oxygen species (ROS) in chromium and insulin stimulated glucose transport using antioxidants. Effect of chromium ions on phosphatases, enzymes involved in inhibition of insulin signaling was also investigated. Experiments were performed in vitro on C2C12 mouse myotubes. ROS level was measured with the use of confocal microscope and 2',7' dichlorodihydrofluorescein diacetate (DCFH-DA)...
January 2018: Journal of Trace Elements in Medicine and Biology
Ankica Sekovanić, Jasna Jurasović, Martina Piasek, Daria Pašalić, Tatjana Orct, Antonija Sulimanec Grgec, Sandra Stasenko, Karmen Branović Čakanić, Anamarija Jazbec
The main source of exposure for all essential and toxic elements in the general population is diet. In smokers, the main route for cadmium (Cd) and lead (Pb) intake is the inhalation of tobacco smoke. Besides gender, age, nutrition, lifestyle, and physiological conditions such as pregnancy, specific genetic characteristics also influence individual element uptake. Metallothionein MT2 is a cysteine-rich low-weight protein found ubiquitously throughout the body. Specific gene polymorphism may influence MT2 expression and subsequent binding, transfer and organ accumulation of metals, though data on these influences are lacking, especially in human mother-newborn pairs...
January 2018: Journal of Trace Elements in Medicine and Biology
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