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Inflammatory Bowel Diseases

Orlaith B Kelly, Nicole Li, Michelle Smith, Jonathan Chan, Robert D Inman, Mark S Silverberg
Background: Sacroiliitis, an inflammatory arthropathy associated with ankylosing spondylitis (AS), is found in patients with inflammatory bowel disease (IBD) but may go undiagnosed. The aims of this study were to assess prevalence of sacroiliitis in IBD and to determine association between clinical characteristics of IBD and sacroiliitis. Methods: Inflammatory bowel disease patients undergoing abdomino-pelvic computed tomography (CT) for any indication (2006-2015) were identified...
November 14, 2018: Inflammatory Bowel Diseases
Zunirah Ahmed, Shashank Sarvepalli, Ari Garber, Miguel Regueiro, Maged K Rizk
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with significant resource utilization and health care burden. It is emerging as a global disease affecting an increasing proportion of the population. Along with evolving epidemiological trends, the paradigm of managing IBD has also changed. With a burgeoning repertoire of therapeutic options, improved use of health informatics, and emphasis on health care value, the treatment paradigm for IBD has experienced seismic shifts. In this review, we focused on value-based health care (VBHC)-a health care model that emphasizes monitoring outcomes to emphasize patient-centered, cost-effective IBD patient care...
November 9, 2018: Inflammatory Bowel Diseases
Javier Francisco Viada Bris, Marta Velasco Rodríguez-Belvís, Carmen de Lucas Collantes, Cristina Aparicio López, Amelia Martínez de Azagra, Gema de Lama Caro-Patón, Inmaculada de Prada Vicente, Rosa Ana Muñoz Codoceo
No abstract text is available yet for this article.
November 8, 2018: Inflammatory Bowel Diseases
Greeshma Ray, Michelle S Longworth
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders affecting the gastrointestinal tract. The incidence of IBD is increasing, with more cases occurring in developed countries. Multiple factors such as genetics, environmental changes, gut microbiota, and immune abnormalities have been associated with development of IBD. In recent years, it has become increasingly apparent that epigenetic modifications of chromatin and the manner in which chromatin is organized in the nucleus are additionally important elements that can influence responses induced by the factors described above, and may therefore contribute to the onset and pathogenesis of IBD...
November 8, 2018: Inflammatory Bowel Diseases
Taha Qazi, Rashmi Verma, Matthew J Hamilton, Emily R Kaplan, Susan Redline, Robert Burakoff
Background: Sleep disturbances (SDs) are commonly reported in patients with Crohn's disease (CD). Several survey instruments assessing subjective measures of insufficient sleep have identified SDs in subjects with CD. However, there are limited data on objective measures of SDs in these patients as they relate to disease activity. In this prospective cross-sectional study, we compared objective estimates of sleep obtained using multiday wrist actigraphy in individuals with CD with varying disease activity...
November 5, 2018: Inflammatory Bowel Diseases
Abdulmaleek Idanesimhe Sado, Rahul Kalla, Abishek Sharma
No abstract text is available yet for this article.
November 5, 2018: Inflammatory Bowel Diseases
Taha Qazi, Francis A Farraye
November 2, 2018: Inflammatory Bowel Diseases
Robert Venning Bryant, Christopher G Schultz, Soong Ooi, Charlotte Goess, Samuel Paul Costello, Andrew D Vincent, Scott Schoeman, Amanda Lim, Francis Dylan Bartholomeusz, Simon P L Travis, Jane Mary Andrews
No abstract text is available yet for this article.
October 31, 2018: Inflammatory Bowel Diseases
Cong Dai, Min Jiang, Yu-Hong Huang
No abstract text is available yet for this article.
October 31, 2018: Inflammatory Bowel Diseases
Taylor Schmidt, Linda A Feagins
October 31, 2018: Inflammatory Bowel Diseases
Brian G Feagan, Stefan Schreiber, Douglas C Wolf, Jeffrey L Axler, Arpeat Kaviya, Alexandra James, Rebecca I Curtis, Parnia Geransar, Andreas Stallmach, Robert Ehehalt, Bernd Bokemeyer, Javaria Mona Khalid, Sharon O'Byrne
Background: Sustaining clinical remission is an important treatment goal in moderate-to-severe UC. This post hoc exploratory analysis assessed the long-term efficacy of vedolizumab in the subset of patients with UC in the GEMINI 1 study who were in clinical remission by week 14 after 3 induction doses, administered at weeks 0, 2, and 6. Methods: Sustained clinical remission (primary endpoint) was evaluated using 2 definitions: (1) a partial Mayo Score (pMS) of ≤2 with no subscore >1 and (2) a rectal bleeding subscore (RBS) of 0 throughout weeks 14, 26, 38, and 52...
October 25, 2018: Inflammatory Bowel Diseases
Arun Swaminath, Eric P Berlin, Adam Cheifetz, Ed Hoffenberg, Jami Kinnucan, Laura Wingate, Sarah Buchanan, Nada Zmeter, David T Rubin
There is significant interest among patients and providers in using cannabis (marijuana) and its derivatives to treat a number of chronic illnesses, including inflammatory bowel disease. Despite the Schedule I classification of cannabis by the federal government, state governments have sought ways to make cannabis available for specific medical conditions, and some states have legalized cannabis outright. This white paper summarizes the preclinical data, clinical data, safety data, and the regulatory landscape as they apply to medical cannabis use in inflammatory bowel disease...
October 24, 2018: Inflammatory Bowel Diseases
Itai Ghersin, Neron Khateeb, Lior H Katz, Saleh Daher, Raanan Shamir, Amit Assa
Background: Growth impairment is common in pediatric inflammatory bowel disease (IBD) patients. Nevertheless, a controversy exists regarding disease impact on anthropometric measures in the long term. Thus, we aimed to investigate the impact of IBD on anthropometric measures, including weight, height, and body mass index (BMI), during late adolescence in a cross-sectional, population-based study. Methods: A total of 1,144,213 Jewish Israeli adolescents who underwent a general health examination from 2002 to 2016 at a median age (interquartile range) of 17...
October 24, 2018: Inflammatory Bowel Diseases
Kimi Drobin, Ghazaleh Assadi, Mun-Gwan Hong, Eni Andersson, Claudia Fredolini, Björn Forsström, Anna Reznichenko, Tahmina Akhter, Weronica E Ek, Ferdinando Bonfiglio, Mark Berner Hansen, Kristian Sandberg, Dario Greco, Dirk Repsilber, Jochen M Schwenk, Mauro D'Amato, Jonas Halfvarson
Background: Few studies have investigated the blood proteome of inflammatory bowel disease (IBD). We characterized the serum abundance of proteins encoded at 163 known IBD risk loci and tested these proteins for their biomarker discovery potential. Methods: Based on the Human Protein Atlas (HPA) antibody availability, 218 proteins from genes mapping at 163 IBD risk loci were selected. Targeted serum protein profiles from 49 Crohn's disease (CD) patients, 51 ulcerative colitis (UC) patients, and 50 sex- and age-matched healthy individuals were obtained using multiplexed antibody suspension bead array assays...
October 24, 2018: Inflammatory Bowel Diseases
Nikolas Dovrolis, Ioannis Drygiannakis, Eirini Filidou, Leonidas Kandilogiannakis, Konstantinos Arvanitidis, Ioannis Tentes, George Kolios, Vassilis Valatas
Microflora dysbiosis is implicated in the pathophysiology of Crohn's disease. This work analyzes differences in microbial communities and relevant metabolic pathways among the nonstricturing nonpenetrating (B1), stricturing (B2), and penetrating (B3) subphenotypes of Crohn's disease vs healthy controls. We conducted a bioinformatics analysis using the QIIME pipeline and the Calypso, linear discriminant analysis effect size, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States, and STAMP tools on publicly available 16S bacterial rRNA sequencing data from terminal ileum mucosal biopsies of healthy controls and the 3 subphenotypes of Crohn's disease...
October 19, 2018: Inflammatory Bowel Diseases
Sang Hyoung Park, Satimai Aniwan, W Scott Harmsen, William J Tremaine, Amy L Lightner, William A Faubion, Edward V Loftus
Background: This study sought to re-estimate the cumulative incidence of perianal or rectovaginal fistulas and the associated proctectomy rate in the prebiologic era vs the biologic era using a population-based cohort of Crohn's disease (CD) patients. Methods: The medical records of 414 residents of Olmsted County, Minnesota, who were diagnosed with CD between 1970 and 2010 were reviewed. The cumulative incidence of perianal or rectovaginal fistulas from time of CD diagnosis and the cumulative rate of proctectomy from date of first perianal or rectovaginal fistula diagnosis were estimated using the Kaplan-Meier method...
October 19, 2018: Inflammatory Bowel Diseases
Adam V Weizman, Geoffrey C Nguyen, Cynthia H Seow, Laura Targownik, Sanjay K Murthy, Karen Boland, Nooran M Afzal, Reena Khanna, Jennifer Jones, Waqqas Afif, Smita Halder, Jason Reinglas, Sharyle Fowler, Vivian Huang, Gilaad G Kaplan, Gil Y Melmed
Background: 3 classes of biologics are now available for the treatment of Crohn's disease. The availability of multiple treatment options has led to questions regarding the appropriateness of each agent for a given patient. We aimed to evaluate physician preferences for the use of specific biologic agents in a variety of Crohn's disease management scenarios using the RAND/UCLA Appropriateness Methodology. Methods: A panel consisting of members of the CINERGI group (Canadian IBD Network for Research and Growth in Quality Improvement) was assembled...
October 19, 2018: Inflammatory Bowel Diseases
Ren Mao, Satya Kurada, Ilyssa O Gordon, Mark E Baker, Namita Gandhi, Christine McDonald, J Calvin Coffey, Florian Rieder
Adipose tissue is present in close proximity to various organs in the human body. One prominent example is fat contained in the mesentery that is contiguous with all abdominal digestive organs including the intestine. Despite the fact that mesenteric fat-wrapping around the inflamed gut (so called "creeping fat") was described as a characteristic feature of Crohn's disease (CD) in the early 1930s, the functional implications of creeping fat have received only recent attention. As a potent producer of fatty acids, cytokines, growth factors, and adipokines, creeping fat plays an important role in regulation of immunity and inflammation...
October 19, 2018: Inflammatory Bowel Diseases
Nikolas Plevris, Mathew Lyons, Philip W Jenkinson, Cher S Chuah, Lynne M Merchant, Rebecca J Pattenden, Eleanor F Watson, Gwo-Tzer Ho, Colin L Noble, Alan G Shand, Shahida Din, Ian D Arnott, Gareth R Jones, Charlie W Lees
Background: Adalimumab is an established treatment for Crohn's disease. Limited data are available regarding the relationship between adalimumab drug levels and serum/fecal markers of gut inflammation. We therefore aimed to characterize the relationship between adalimumab levels and biologic remission during maintenance therapy. Methods: A single-center prospective cross-sectional study was undertaken on Crohn's disease patients who had received adalimumab therapy for a minimum of 12 weeks after induction...
October 17, 2018: Inflammatory Bowel Diseases
Djuna C de Jong, Mark Löwenberg, Ioannis Koumoutsos, Shuvra Ray, Joel Mawdsley, Simon Anderson, Jeremy D Sanderson, Krisztina Gecse, Cyriel Y Ponsioen, Geert R D'Haens, Peter M Irving, Mark A Samaan
Background: The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is a novel instrument to evaluate endoscopic disease activity. It has been demonstrated to outperform the more widely used Mayo endoscopic score (MES) in predicting long-term prognosis, including the need for colectomy. Despite its potential benefits, many clinicians still prefer to use MES because its operating characteristics are better defined and its grades are more readily applicable to clinical decision-making...
October 17, 2018: Inflammatory Bowel Diseases
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