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Inflammatory Bowel Diseases

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https://www.readbyqxmd.com/read/28806280/integrated-analysis-of-biopsies-from-inflammatory-bowel-disease-patients-identifies-saa1-as-a-link-between-mucosal-microbes-with-th17-and-th22-cells
#1
Mei San Tang, Rowann Bowcutt, Jacqueline M Leung, Martin J Wolff, Uma M Gundra, David Hudesman, Lisa B Malter, Michael A Poles, Lea Ann Chen, Zhiheng Pei, Antonio G Neto, Wasif M Abidi, Thomas Ullman, Lloyd Mayer, Richard A Bonneau, Ilseung Cho, Pʼng Loke
BACKGROUND: Inflammatory bowel diseases (IBD) are believed to be driven by dysregulated interactions between the host and the gut microbiota. Our goal is to characterize and infer relationships between mucosal T cells, the host tissue environment, and microbial communities in patients with IBD who will serve as basis for mechanistic studies on human IBD. METHODS: We characterized mucosal CD4 T cells using flow cytometry, along with matching mucosal global gene expression and microbial communities data from 35 pinch biopsy samples from patients with IBD...
August 9, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28795970/machine-learning-based-gene-prioritization-identifies-novel-candidate-risk-genes-for-inflammatory-bowel-disease
#2
Ofer Isakov, Iris Dotan, Shay Ben-Shachar
BACKGROUND: The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes are implicated in IBD etiology, it is likely that additional genes play a role in the disease process. We developed a machine learning-based gene prioritization method to identify novel IBD-risk genes. METHODS: Known IBD genes were collected from genome-wide association studies and annotated with expression and pathway information...
August 8, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28795969/e-cadherin-mediates-the-preventive-effect-of-vitamin-d3-in-colitis-associated-carcinogenesis
#3
Yu Xin, Longmei He, Zijian Luan, Hong Lv, Hong Yang, Ying Zhou, Xinhua Zhao, Weixun Zhou, Songlin Yu, Bei Tan, Hongying Wang, Jiaming Qian
Vitamin D3 is beneficial in ameliorating or preventing inflammation and carcinogenesis. Here, we evaluated if vitamin D3 has a preventive effect on colitis-associated carcinogenesis. Administration of azoxymethane (AOM), followed with dextran sulfate sodium (DSS), was used to simulate colitis-associated colon cancer in mice. The supplement of vitamin D3 at different dosages (15, 30, 60 IU·g·w), started before AOM or immediately after DSS treatment (post 60), was sustained to the end of the experiment. Dietary vitamin D3 significantly reduced the number of tumors and tumor burden in a dose-dependent manner...
August 8, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786870/importance-of-considering-the-financial-cost-in-assessing-quality-of-care
#4
Christopher H Blevins, Sunanda V Kane
No abstract text is available yet for this article.
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786869/reply
#5
Samuel R Fernandes, Rita V Rodrigues, Sónia Bernardo, João Cortez-Pinto, Isadora Rosa, João Pereira da Silva, Ana R Gonçalves, Ana Valente, Cilénia Baldaia, Paula Moura Santos, Luís A Correia, José Venâncio, Paula Campos, António Dias Pereira, José Velosa
No abstract text is available yet for this article.
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786868/transmural-healing-and-mri-remission-new-promising-therapeutic-targets-in-crohn-s-disease
#6
Anthony Buisson, Constance Hordonneau, Parakkal Deepak
No abstract text is available yet for this article.
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786867/combination-therapy-with-dose-optimized-thiopurine-and-adalimumab-in-crohn-s-disease
#7
Zubin Grover
No abstract text is available yet for this article.
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786866/management-of-the-psychological-impact-of-inflammatory-bowel-disease-perspective-of-doctors-and-patients-the-enmente-project
#8
Ignacio Marín-Jiménez, Milena Gobbo Montoya, Abel Panadero, Mercedes Cañas, Yolanda Modino, Cristina Romero de Santos, Jordi Guardiola, Loreto Carmona, Manuel Barreiro-de Acosta
BACKGROUND: To explore the perception of patients and gastroenterologists specialized in inflammatory bowel disease (IBD) on the impact of psychological factors on IBD course and its management. METHODS: Online surveys were sent to patients with IBD recruited from a national patient association and IBD specialists recruited from a national scientific society. These surveys were based on the results of a focus group and discussion group that explored the psychological aspects of IBD...
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28786865/thiopurines-dosed-to-a-therapeutic-6-thioguanine-level-in-combination-with-adalimumab-are-more-effective-than-subtherapeutic-thiopurine-based-combination-therapy-or-adalimumab-monotherapy-during-induction-and-maintenance-in-patients-with-long-standing-crohn
#9
Viraj C Kariyawasam, Mark G Ward, Paul A Blaker, Kamal V Patel, Rishi Goel, Jeremy D Sanderson, Peter M Irving
BACKGROUND: The benefit of concomitant immunomodulation with adalimumab (ADA) in Crohn's disease is poorly understood. We aimed to compare ADA monotherapy with combination therapy with thiopurines, stratified by thioguanine nucleotides (TGNs). METHODS: Retrospective observational study of ADA induction and maintenance. Thiopurines were classified according to TGNs (>235 pmol/8 × 10 red blood cell therapeutic). RESULTS: At induction, response was more frequent in combination than ADA monotherapy (83% versus 61%, P = 0...
August 3, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28777099/inflammatory-bowel-diseases-review-of-known-environmental-protective-and-risk-factors-involved
#10
Kimberley W J van der Sloot, Marzyeh Amini, Vera Peters, Gerard Dijkstra, Behrooz Z Alizadeh
Inflammatory bowel diseases consisting of Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. In addition to genetic susceptibility and disturbances of the microbiome, environmental exposures forming the exposome play an important role. Starting at birth, the cumulative effect of different environmental exposures combined with a predetermined genetic susceptibility is thought to cause inflammatory bowel disease. All these environmental factors are part of a Western lifestyle, suiting the high incidence rates in Europe and the United States...
August 2, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28700535/vitamin-d-status-is-associated-with-hepcidin-and-hemoglobin-concentrations-in-children-with-inflammatory-bowel-disease
#11
Sana Syed, Ellen S Michalski, Vin Tangpricha, Supavit Chesdachai, Archana Kumar, Jarod Prince, Thomas R Ziegler, Parminder S Suchdev, Subra Kugathasan
BACKGROUND: Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines. METHODS: We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD...
July 11, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28700534/clinical-predictors-of-future-nonadherence-in-inflammatory-bowel-disease
#12
Mirjam Severs, Marie-Josée J Mangen, Herma H Fidder, Mirthe E van der Valk, Mike van der Have, Ad A van Bodegraven, Cees H M Clemens, Gerard Dijkstra, Jeroen M Jansen, Dirk J de Jong, Nofel Mahmmod, Paul C van de Meeberg, Andrea E van der Meulen-de Jong, Marieke Pierik, Cyriel Y Ponsioen, Marielle J L Romberg-Camps, Peter D Siersema, Bindia Jharap, Janneke C van der Woude, Nicolaas P A Zuithoff, Bas Oldenburg
BACKGROUND: Nonadherence to medical therapy is frequently encountered in patients with inflammatory bowel disease (IBD). We aimed to identify predictors for future (non)adherence in IBD. METHODS: We conducted a multicenter prospective cohort study with adult patients with Crohn's disease (CD) and ulcerative colitis (UC). Data were collected by means of 3-monthly questionnaires on the course of disease and healthcare utilization. Medication adherence was assessed using a visual analogue scale, ranging from 0% to 100%...
July 11, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28700533/cd103-dendritic-cell-function-is-altered-in-the-colons-of-patients-with-ulcerative-colitis
#13
Hiroshi Matsuno, Hisako Kayama, Junichi Nishimura, Yuki Sekido, Hideki Osawa, Soumik Barman, Takayuki Ogino, Hidekazu Takahashi, Naotsugu Haraguchi, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Motoi Uchino, Hiroki Ikeuchi, Yuichiro Doki, Masaki Mori, Kiyoshi Takeda, Tsunekazu Mizushima
BACKGROUND: Human intestinal innate myeloid cells can be divided into 3 subsets: HLA-DRCD14 cells, HLA-DRCD103 dendritic cells (DCs), and HLA-DRCD14CD103 cells. CD103 DCs generate Treg cells and Th17 cells in the ileum, but their function in the colon remains largely unknown. This study characterized CD103 DCs in the colon and investigated whether these cells are implicated in the pathogenesis of ulcerative colitis (UC). METHODS: Normal intestinal mucosa was obtained from intact sites of patients with colorectal cancer (n = 24)...
July 11, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28696957/association-of-inflammatory-bowel-disease-and-urolithiasis-in-hospitalized-pediatric-patients
#14
Christopher M Stark, Gregory H Gorman, Cade M Nylund
BACKGROUND: Urolithiasis is rare in pediatric patients. All patients with inflammatory bowel disease (IBD) have an increased risk of urolithiasis, but this risk is poorly quantified in children. The objective of this study is to evaluate the association of IBD with urolithiasis, assess surgical outcomes, and analyze the financial burden for children hospitalized with urolithiasis and comorbid IBD. METHODS: The triennial Healthcare Cost and Utilization Project Kids' Inpatient Database for years 1997 to 2012 was used to evaluate the association between urolithiasis and IBD in hospitalized, nonpregnant children ages 5 to 20 years old...
July 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28696956/long-term-outcomes-with-anti-tnf-therapy-and-accelerated-step-up-in-the-prospective-pediatric-belgian-crohn-s-disease-registry-belcro
#15
Lucas Wauters, Françoise Smets, Elisabeth De Greef, Patrick Bontems, Ilse Hoffman, Bruno Hauser, Philippe Alliet, Wim Arts, Harald Peeters, Stephanie Van Biervliet, Isabelle Paquot, Els Van de Vijver, Martine De Vos, Peter Bossuyt, Jean-François Rahier, Olivier Dewit, Tom Moreels, Denis Franchimont, Vincianne Muls, Fernand Fontaine, Edouard Louis, Jean-Charles Coche, Filip Baert, Jérôme Paul, Séverine Vermeire, Geneviève Veereman
BACKGROUND: Accelerated step-up or anti-tumor necrosis factor (TNF) before first remission is currently not recommended in pediatric Crohn's disease. METHODS: Five-year follow-up data from a prospective observational cohort of children diagnosed with Crohn's disease in Belgium were analyzed. Disease severity was scored as inactive, mild, or moderate to severe. Remission or inactive disease was defined as sustained if lasting ≥2 years. Univariate analyses were performed between anti-TNF-exposed versus naive patients and anti-TNF before versus after first remission and correlations assessed with primary outcomes average disease severity and sustained remission...
July 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28691940/endoscopic-balloon-dilation-size-and-avoidance-of-surgery-in-stricturing-crohn-s-disease
#16
Bethany A Reutemann, Joshua A Turkeltaub, Mahmoud Al-Hawary, Akbar K Waljee, Peter D R Higgins, Ryan W Stidham
BACKGROUND: Endoscopic balloon dilation (EBD) is an effective method for treating stricture-related obstruction in Crohn's disease. We aimed to identify factors predictive of successful avoidance of surgery, including endoscopic features, in patients undergoing balloon dilation. METHODS: We performed a retrospective review of patients with symptomatic Crohn's disease-related intestinal strictures undergoing EBD. Clinical, medication use, laboratory, and dilation data, including the minimum and maximum balloon sizes used, and number of balloons used per endoscopic session were collected...
July 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28691939/autoantibodies-against-glycoprotein-2-isoforms-in-pediatric-patients-with-inflammatory-bowel-disease
#17
Nadja Röber, Lydia Noß, Alexander Goihl, Dirk Reinhold, Josefine Jahn, Jan de Laffolie, Wolf Johannes, Gunter M Flemming, Dirk Roggenbuck, Karsten Conrad, Martin W Laass
BACKGROUND: Anti-Glycoprotein 2 (GP2) antibodies are associated with a more complicated course of Crohn's disease (CD) in adults. Four different GP2 isoforms with different length and antibody-binding sites have been identified so far but not been explored in serological studies. We aimed to investigate the diagnostic utility of autoantibodies against all 4 isoforms of GP2 in an exclusively pediatric population for the first time. METHODS: We included 278 children and adolescents with inflammatory bowel disease: 164 with CD, 114 with ulcerative colitis, 83 disease controls (acute gastrointestinal infection, nonspecific gastrointestinal functional disorders), and 219 healthy controls...
July 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28682807/development-and-validation-of-a-novel-prediction-model-for-differential-diagnosis-between-crohn-s-disease-and-intestinal-tuberculosis
#18
Jung Ho Bae, Sang Hyoung Park, Byong Duk Ye, Seon-Ok Kim, Yun Kyung Cho, Eun Ja Youn, Ho-Su Lee, Sung Wook Hwang, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang
BACKGROUND: Although colonoscopy is useful for differentiating between Crohn's disease (CD) and intestinal tuberculosis (ITB), the technique has limitations. We developed a practical prediction model for differentiating between CD and ITB using laboratory and radiologic parameters and colonoscopic characteristics. METHODS: We prospectively enrolled 80 patients newly diagnosed with CD (n = 40) and ITB (n = 40). We developed a new prediction score by integrating colonoscopic, laboratory, and radiologic parameters...
June 28, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28691941/extraintestinal-manifestations-are-common-in-obese-patients-with-crohn-s-disease
#19
Manish B Singla, Christa Eickhoff, John Betteridge
INTRODUCTION: Crohn's disease (CD) is a chronic condition associated with the risk of malabsorption. The incidence of obesity worldwide is increasing, and the effect of obesity on patients with CD is unknown. We aim to identify traits related to obesity in a cohort of patients with CD. METHODS: We conducted a retrospective study of 209 adult patients with CD. Age, Montreal disease classification, sex, race, duration of disease, erythrocyte sedimentation rate, C-reactive protein levels, physician global assessment, endoscopic appearance, histologic activity, medication use, and body mass index (BMI) were collected about each patient...
June 27, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28644185/a-simple-ultrasound-score-for-the-accurate-detection-of-inflammatory-activity-in-crohn-s-disease
#20
Kerri L Novak, Gilaad G Kaplan, Remo Panaccione, Elnaz Ehteshami Afshar, Divine Tanyingoh, Mark Swain, Amelia Kellar, Stephanie Wilson
BACKGROUND: Ultrasound is accurate in the detection of Crohn's disease. Our aim was to identify ultrasound parameters contributing to inflammatory disease activity, develop a simple score, and validate this score prospectively. METHODS: This study comprised 2 single-center investigations. The first was a retrospective study on a population that had received colonoscopies (as a gold-standard diagnostic) within 60 days of ultrasound. The second was a prospective study on 2 populations: patients requiring induction with adalimumab and patients on adalimumab maintenance therapy...
June 20, 2017: Inflammatory Bowel Diseases
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