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Inflammatory Bowel Diseases

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https://www.readbyqxmd.com/read/29992302/limited-health-literacy-is-associated-with-worse-patient-reported-outcomes-in-inflammatory-bowel-disease
#1
Lauren K Tormey, Jason Reich, Yu Sarah Chen, Arush Singh, Zachary Lipkin-Moore, Anzhu Yu, Janice Weinberg, Francis A Farraye, Michael K Paasche-Orlow
Background: Patients with inflammatory bowel disease (IBD) face complex health tasks and decisions. Limited health literacy is a risk factor for poor health outcomes, but this has not been examined in IBD. This study aims to assess the role of health literacy for patients with IBD. Methods: We prospectively enrolled adults with IBD receiving care from the Section of Gastroenterology at the Boston Medical Center. In-person, standardized questionnaires were administered to measure health literacy with the Newest Vital Sign, self-efficacy with the Medication Use and Self-Efficacy Scale, quality of life with the 10-question Short Inflammatory Bowel Disease Questionnaire, depression with the Patient-Reported Outcomes Measurement System Short Form, and clinical disease activity for patients with Crohn's disease with the Harvey-Bradshaw Index and for patients with ulcerative colitis with the Simple Clinical Colitis Activity Index (SCCAI)...
July 10, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29992248/association-between-ibd-disability-and-reduced-work-productivity-presenteeism-a-population-based-study-in-manitoba-canada
#2
Leigh Ann Shafer, John R Walker, Gayle Restall, Tarun Chhibba, Meloney Ivekovic, Harminder Singh, Laura E Targownik, Charles N Bernstein
Background: One effect of IBD disability is reduced productivity when at work (presenteeism). We explored potential predictors of work presenteeism and compared the predictive ability of the recently developed IBD Disability Index (IBDDI) with 4 other scales in predicting presenteeism. Methods: Participants (aged 18-65 years) were recruited from the University of Manitoba IBD Research Registry. We calculated a presenteeism score (range, 0-24) from the Stanford Presenteeism Scale (SPS), with higher scores representing greater degrees of presenteeism...
July 10, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29986021/increased-burden-of-psychiatric-disorders-in-inflammatory-bowel-disease
#3
Charles N Bernstein, Carol A Hitchon, Randy Walld, James M Bolton, Jitender Sareen, John R Walker, Lesley A Graff, Scott B Patten, Alexander Singer, Lisa M Lix, Renée El-Gabalawy, Alan Katz, John D Fisk, Ruth Ann Marrie
Background: Psychiatric comorbidity in inflammatory bowel disease (IBD) is well known; however, data from a truly representative sample are sparse. We aimed to estimate the incidence and prevalence of psychiatric disorders in an IBD cohort compared with a matched cohort without IBD. Methods: Using population-based administrative health data from Manitoba, Canada, we identified all persons with incident IBD from 1989 to 2012 and a general population matched cohort (5:1)...
July 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29986015/starting-young-trends-in-opioid-therapy-among-us-adolescents-and-young-adults-with-inflammatory-bowel-disease-in-the-truven-marketscan-database-between-2007-and-2015
#4
Anava A Wren, Rachel Bensen, Lindsay Sceats, Melody Dehghan, Helen Yu, Jessie J Wong, Donna MacIsaac, Zachary M Sellers, Cindy Kin, K T Park
Background: Opioids are commonly prescribed for relief in inflammatory bowel disease (IBD). Emerging evidence suggests that adolescents and young adults are a vulnerable population at particular risk of becoming chronic opioid users and experiencing adverse effects. Objectives: This study evaluates trends in the prevalence and persistence of chronic opioid therapy in adolescents and young adults with IBD in the United States. Method: A longitudinal retrospective cohort analysis was conducted with the Truven MarketScan Database from 2007 to 2015...
July 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29986006/chronic-opioid-use-among-youth-with-inflammatory-bowel-disease-a-new-approach-is-needed
#5
M Ellen Kuenzig, Eric I Benchimol
No abstract text is available yet for this article.
July 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982631/continuous-clinical-response-is-associated-with-a-change-of-disease-course-in-patients-with-moderate-to-severe-ulcerative-colitis-treated-with-golimumab
#6
Walter Reinisch, Jean-Frederic Colombel, Peter R Gibson, Paul Rutgeerts, William J Sandborn, Dino Tarabar, Susan Huyck, Ahmed Khalifa, Colleen Marano, George Philip, Ruji Yao, Hongyan Zhang, Freddy Cornillie
Background: Responders to induction treatment sustain continuous clinical response (CCR) through 1 year in about 50% of patients in PURSUIT-M trial with golimumab maintenance in ulcerative colitis (UC). This post hoc analysis of PURSUIT-M describes the 1-year clinical, endoscopic, quality of life (QoL), and biomarker and 4-year clinical outcome in patients with sustained response to golimumab therapy for UC. Methods: We compared clinical, endoscopic, QoL, and calprotectin outcomes in CCR and non-CCR patients through 54 weeks in PURSUIT-M...
July 6, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982654/corrigendum-to-evaluation-of-the-quality-of-semen-and-sexual-function-in-men-with-inflammatory-bowel-disease
#7
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982646/frequency-of-herpes-zoster-vaccination-among-inflammatory-bowel-disease-patients
#8
Nabeel Khan, Chinmay Trivedi, Himanshu Kavani, James Lewis, Yu-Xiao Yang
Background: Inflammatory bowel disease (IBD) patients are at an increased risk of herpes zoster (HZ). Our aim was to determine the frequency of HZ vaccination and the factors associated with it among eligible IBD patients. Methods: We conducted a retrospective cohort study among IBD patients who were followed in the nationwide Veterans Affairs Healthcare system. Among this cohort, we identified patients who were the age of 60 years after the introduction of the vaccination...
July 5, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982526/corrigendum-to-reviewing-the-risk-of-colorectal-cancer-in-inflammatory-bowel-disease-after-liver-transplantation-for-primary-sclerosing-cholangitis
#9
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982468/predicting-risk-of-postoperative-disease-recurrence-in-crohn-s-disease-patients-with-indolent-crohn-s-disease-have-distinct-whole-transcriptome-profiles-at-the-time-of-first-surgery
#10
Kelly C Cushing, Richard Mclean, Keely G McDonald, Jenny K Gustafsson, Kathryn A Knoop, Devesha H Kulkarni, R Balfour Sartor, Rodney D Newberry
Background: Assessing risk of Crohn's disease (CD) recurrence following ileocolic resection (ICR) is necessary to optimize medical management and prevent long-term complications. This study aimed to identify noninvasive markers that could predict postoperative disease activity. Methods: Inclusion criteria were a diagnosis of CD, first ICR, interval colonoscopy, and whole transcriptome array meeting quality control standards. Demographic and clinical data were obtained from the electronic medical record...
July 5, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982480/intestinal-inflammation-and-tumor-burden-as-determinants-for-bone-fragility-in-apc-driven-tumorigenesis
#11
Dominik Saul, Arndt F Schilling, Robyn Laura Kosinsky
Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths, and tumor-related comorbidities additionally lower life quality and survival. Mutations in the tumor suppressor adenomatous polyposis coli (APC) are associated with sporadic CRC and familial adenomatous polyposis (FAP), which results in the growth of multiple intestinal cancer lesions. In some cases, inflammatory bowel diseases (IBDs) are additionally observed in CRC patients. Although APC mutations have been shown to increase bone mineral density (BMD), inflammation is associated with reduced BMD and an elevated fracture risk in IBD patients...
July 3, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29982686/outcomes-of-pregnancies-with-maternal-paternal-exposure-in-the-tofacitinib-safety-databases-for-ulcerative-colitis
#12
Uma Mahadevan, Marla C Dubinsky, Chinyu Su, Nervin Lawendy, Thomas V Jones, Amy Marren, Haiying Zhang, Daniela Graham, Megan E B Clowse, Steven R Feldman, Daniel C Baumgart
Background: Active inflammatory bowel disease increases the risk of adverse pregnancy outcomes. Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). As a small molecule, tofacitinib is likely to cross the placental barrier; however, information on the effects of tofacitinib on pregnancy outcomes is limited. We report pregnancy and newborn outcomes among patients in UC clinical studies with prenatal (maternal/paternal) exposure to tofacitinib...
July 2, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29961860/erratum-to-targeting-mucosal-endothelin-a-receptor-expression-by-fluorescence-endoscopy-is-feasible-to-detect-and-characterize-colitis-associated-cancer-in-mice
#13
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29961815/idiopathic-thrombocytopenic-purpura-responsive-to-surgery-for-crohn-s-disease
#14
Shinta Mizuno, Makoto Naganuma, Takanori Kanai
No abstract text is available yet for this article.
June 28, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29961844/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
June 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29955853/erratum-to-clinoptilolite-in-dextran-sulphate-sodium-induced-murine-colitis-efficacy-and-safety-of-a-microparticulate-preparation
#16
(no author information available yet)
No abstract text is available yet for this article.
June 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29947795/drug-survival-and-immunogenicity-after-switching-from-remicade-to-biosimilar-ct-p13-in-inflammatory-bowel-disease-patients-two-year-follow-up-of-a-prospective-observational-cohort-study
#17
Lisa J T Smits, Aura A J van Esch, Lauranne A A P Derikx, Ronald Boshuizen, Dirk J de Jong, Joost P H Drenth, Frank Hoentjen
Background: The infliximab biosimilar has entered daily inflammatory bowel disease (IBD) practice. However, real-life outcomes beyond 1 year after switching are scarce. We aimed to investigate the long-term drug survival, immunogenicity, and pharmacokinetics 2 years after switching to CT-P13 in IBD patients. Methods: We performed a single-center prospective observational cohort study in all Remicade-treated IBD patients who previously switched to CT-P13. We systematically documented reasons for discontinuation, trough levels, and antidrug antibodies to infliximab (ADAs) at baseline, week 16, week 52, and week 104...
June 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29947781/mimics-of-inflammatory-bowel-disease
#18
Raina Shivashankar, Gary R Lichtenstein
Inflammatory bowel disease (IBD) may present with nonspecific symptoms and diagnostic findings. Therefore, many diseases may mimic the clinical symptoms, endoscopic findings, and histologic features of IBD. In this paper, we will review mimics of IBD, dividing the diseases that can imitate IBD into noninfectious and infectious causes. For each disease state, we will discuss the clinical symptoms and endoscopic and histologic features. Finally, we will discuss how to distinguish these distinct disorders from IBD...
June 27, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29945208/an-overview-of-molecular-profiles-in-ulcerative-colitis-related-cancer
#19
Meng Xue, Liuhong Shi, Weijia Wang, Shujie Chen, Liangjing Wang
Ulcerative colitis (UC) is an independent risk factor of colorectal cancer (CRC). Both genetic and epigentic events induce a unique molecular profile during the development from UC to UC-related CRC (UCRC). These molecular changes play varied roles in DNA repair, immune response, cell metabolism, and interaction with the microbiota during the carcinogenesis process. This review will systmatically discuss the molecular characteristics of UCRC and point out the future perspectives in this research field.
June 25, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29939252/pouchitis-as-an-indication-for-ileal-pouch-surgical-revision
#20
Matteo Novello, Bo Shen, Luca Stocchi
No abstract text is available yet for this article.
June 25, 2018: Inflammatory Bowel Diseases
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