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Inflammatory Bowel Diseases

Cuifang Zheng, Ying Huang, Wenhui Hu, Jieru Shi, Ziqing Ye, Xiaowen Qian, Zhiheng Huang, Aijuan Xue, Yuhuan Wang, Junping Lu, Zifei Tang, Jie Wu, Lin Wang, Kaiyue Peng, Ying Zhou, Shijian Miao, Hua Sun
Background: Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis. We sought to accurately phenotype this disorder based on a large cohort of patients with a proven defect of IL10 signaling and to clarify the effects of allogeneic hematopoietic stem cell transplantation (HSCT). Methods: We analyzed the phenotypes of our 61 patients and reviewed 78 other previously reported cases with identified mutations in the genes encoding IL10 or IL10R...
September 13, 2018: Inflammatory Bowel Diseases
Robert Venning Bryant, Christopher G Schultz, Soong Ooi, Charlotte Goess, Samuel Paul Costello, Andrew D Vincent, Scott Schoeman, Amanda Lim, Francis Dylan Bartholomeusz, Simon P L Travis, Jane Mary Andrews
Background: Visceral adipose tissue (VAT) has been proposed to play a pathogenic role in Crohn's disease (CD); however, prospective clinical data are lacking. The aim was to evaluate whether VAT, beyond body mass index (BMI), is associated with CD behavior, disease activity, quality of life (QoL), or outcomes. Methods: Body composition data and clinical, anthropometric, disease activity (fecal calprotectin [FC]), and QoL scores were gathered prospectively on adults with CD at 0, 12, and 24 months...
September 12, 2018: Inflammatory Bowel Diseases
Sun Jun
No abstract text is available yet for this article.
September 12, 2018: Inflammatory Bowel Diseases
Aleksandra Szymczak-Tomczak, Iwona Krela-Kazmierczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Agnieszka Dobrowolska, Ryszard Slomski, Piotr Eder
No abstract text is available yet for this article.
September 12, 2018: Inflammatory Bowel Diseases
Margaret Delday, Imke Mulder, Elizabeth T Logan, George Grant
Background: Alterations in the gut microbiota are strongly associated with the development of inflammatory bowel disease (IBD), particularly with Crohn's disease, which is characterized by reduced abundance of commensal anaerobic bacteria including members of the Bacteroides genus. Our aim was to investigate the protective effects of Bacteroides thetaiotaomicron, an abundant member of this genus, in different rodent models of IBD. Methods: We assessed the effect of B...
September 12, 2018: Inflammatory Bowel Diseases
Dario Sorrentino, Vu Q Nguyen
No abstract text is available yet for this article.
September 11, 2018: Inflammatory Bowel Diseases
Stefania Chetcuti Zammit, Mark E McAlindon, Melissa F Hale, David S Sanders, Ailish Healy, Victoria Thurston, Reena Sidhu
No abstract text is available yet for this article.
September 11, 2018: Inflammatory Bowel Diseases
Carlos D Minacapelli, Manisha Bajpai, Xin Geng, James Van Gurp, Elizabeth Poplin, Peter S Amenta, Steven R Brant, Kiron M Das
Background: MicroRNAs (miRNAs) are important post-translational regulators. Elevated levels of miR-206 in ulcerative colitis (UC) were associated with suppression of anti-inflammatory A3 adenosine receptor (A3AR) expression. However, the relationship of miR-206 to histologic remission in UC patients remains unknown. This study correlates expression levels of miR-206 with histologic remission in patients treated via long-term mesalamine treatment to identify a possible mode of action for this mainstay drug for UC...
September 11, 2018: Inflammatory Bowel Diseases
Nienke Z Borren, Hamed Khalili, Jay Luther, Francis P Colizzo, John J Garber, Ashwin N Ananthakrishnan
Background: Acute severe ulcerative colitis (ASUC) is a serious complication of ulcerative colitis (UC). Management of partial responders to steroids or rescue therapy remains challenging. Whether there is a role for re-look sigmoidoscopic evaluation in disease management is unknown. Methods: Our study cohort consisted of patients who underwent 2 sigmoidoscopic procedures during the same index hospitalization for ASUC at our center. Reasons for repeat endoscopic evaluation and endoscopic and histologic severity of inflammation during both procedures were noted...
September 11, 2018: Inflammatory Bowel Diseases
Jason Reich, Ling Guo, Jacob Groshek, Janice Weinberg, Wenli Chen, Christopher Martin, Millie D Long, Francis A Farraye
Introduction: There has been growing interest in social media use in managing chronic illnesses. The aim of this study was to assess social media usage in a large sample of patients with inflammatory bowel disease (IBD). Methods: We performed a cross-sectional study within the Crohn's and Colitis Foundation's IBD Partners' internet-based cohort. We used bivariate analyses to compare patient characteristics by various factors associated with social media utilization...
September 7, 2018: Inflammatory Bowel Diseases
Sunanda Kane
No abstract text is available yet for this article.
September 7, 2018: Inflammatory Bowel Diseases
Isabella Dotti, Azucena Salas
Inflammatory bowel disease (IBD) is a chronic remitting disorder with increasing incidence worldwide. The intestinal epithelial barrier plays a major role in IBD, contributing to its pathogenesis, evolution, and perpetuation over time. Until recently, studies focused on exploring the role of the intestinal epithelium in IBD were hampered by the lack of techniques for the long-term culturing of human primary epithelial cells ex vivo. Recently, however, a methodology for generating stable human 3D epithelial cultures directly from adult intestinal stem cells was established...
August 29, 2018: Inflammatory Bowel Diseases
Belinda D Jackson, Peter De Cruz
The rising burden of inflammatory bowel disease (IBD) has the potential to have a negative impact on the quality of care delivered to patients with IBD. Quality of care has been described by the World Health Organization as "the extent to which health care services provided to individuals and patient populations improve desired health outcomes." Variation in care has been identified as a key barrier to achieving quality of care in IBD. Assessment of quality of care attempts to minimize variation in care...
August 29, 2018: Inflammatory Bowel Diseases
Kati Choi, Hamzah Abu-Sbeih, Rashmi Samdani, Graciela Nogueras Gonzalez, Gottumukkala Subba Raju, David M Richards, Jianjun Gao, Sumit Subudhi, John Stroehlein, Yinghong Wang
Background: Microscopic colitis (MC) has been described as 1 pattern of injury in immune checkpoint inhibitor (ICPI)-induced colitis. The main objective of this study was to characterize ICPI-induced MC by exploring the differences in risk factors, colitis treatments, endoscopic features, and clinical outcomes between cancer and noncancer patients with MC with and without exposure to ICPIs. Methods: A retrospective chart review was conducted among patients diagnosed with MC from our institutional pathology database from January 2012 to January 2018...
August 29, 2018: Inflammatory Bowel Diseases
Alain Bitton, Maria Vutcovici, Ellina Lytvyak, Natasha Kachan, Brian Bressler, Jennifer Jones, Peter L Lakatos, Maida Sewitch, Wael El-Matary, Gil Melmed, Geoffrey Nguyen
Background: Variation in clinical practice exists in many aspects of inflammatory bowel disease (IBD) care. Our aim was to develop a comprehensive set of quality indicators (QIs) to be measured in view of improving the quality of IBD care provided in clinical practice. This initiative was part of a global Canadian quality initiative PACE (Promoting Access and Care through Centres of Excellence). Methods: A modified RAND appropriateness method was used to identify and rate structure, process, outcome, and patient-derived QIs of IBD care...
August 29, 2018: Inflammatory Bowel Diseases
Afrin Kamal, Ruthvik Padival, Bret Lashner
No abstract text is available yet for this article.
August 29, 2018: Inflammatory Bowel Diseases
Badr Al-Bawardy, Guilherme Piovezani Ramos, Maria Alice V Willrich, Sarah M Jenkins, Sang Hyoung Park, Satimai Aniwan, Shayla A Schoenoff, David H Bruining, Konstantinos A Papadakis, Laura Raffals, William J Tremaine, Edward V Loftus
Background/Aims: The clinical utility of vedolizumab (VDZ) trough levels (VTLs) in inflammatory bowel disease (IBD) is not well defined. The aims of this study are to determine the median VTLs and frequency of detected antibodies, the correlation of VTLs with C-reactive protein (CRP) and mucosal healing (MH), and the change in clinical management based on VTLs. Methods: A cross-sectional study of IBD patients treated with VDZ with VTLs checked between July 1, 2016, and March 1, 2017, was conducted...
August 24, 2018: Inflammatory Bowel Diseases
Tamara Pérez-Jeldres, Christopher J Tyler, Joshua D Boyer, Thangaraj Karuppuchamy, Giorgos Bamias, Parambir S Dulai, Brigid S Boland, William J Sandborn, Derek R Patel, Jesús Rivera-Nieves
After 20 years of successful targeting of pro-inflammatory cytokines for the treatment of IBD, an alternative therapeutic strategy has emerged, based on several decades of advances in understanding the pathogenesis of IBD. The targeting of molecules involved in leukocyte traffic has recently become a safe and effective alternative. With 2 currently approved drugs (ie, natalizumab, vedolizumab) and several others in phase 3 trials (eg, etrolizumab, ozanimod, anti-MAdCAM-1), the blockade of trafficking molecules has firmly emerged as a new therapeutic era for IBD...
August 24, 2018: Inflammatory Bowel Diseases
Julia Fritz, Cassandra Walia, Abdul Elkadri, Rebecca Pipkorn, Rachel K Dunn, Rita Sieracki, Praveen S Goday, Jose Mariano Cabrera
Background: This systematic review critically analyzes the current research on micronutrient deficiency in children with inflammatory bowel disease (IBD) and synthesizes these data to provide evidence-based guidelines for nutritional surveillance in this population. Methods: We searched 5 databases (Ovid Medline, PubMed, Scopus, CINAHL, and Cochrane Library) for studies evaluating micronutrients in patients with IBD using the following inclusion criteria: 1) original research, 2) published 1996 or later; 3) published in English; 4) human subjects; and 5) containing pediatric data...
August 21, 2018: Inflammatory Bowel Diseases
Alessandro Armuzzi, Gionata Fiorino, Angela Variola, Natalia Manetti, Walter Fries, Ambrogio Orlando, Giovanni Maconi, Fabrizio Bossa, Maria Cappello, Livia Biancone, Laura Cantoro, Francesco Costa, Renata D'Incà, Paolo Lionetti, Mariabeatrice Principi, Fabiana Castiglione, Maria L Annunziata, Antonio Di Sabatino, Maria Di Girolamo, Maria M Terpin, Claudio C Cortelezzi, Simone Saibeni, Arnaldo Amato, Sandro Ardizzone, Luisa Guidi, Silvio Danese, Arianna Massella, Agostino Ventra, Giulia Rizzuto, Alessandro Massari, Francesco Perri, Vito Annese
Background: We report a prospective, nationwide cohort evaluating the safety and effectiveness of CT-P13. Methods: A structured database was used to record serious adverse events (SAEs), clinical remission/response, inflammatory biomarkers (CRP and calprotectin), and endoscopic findings. Results: Eight hundred ten patients with inflammatory bowel disease (IBD) (452 Crohn's disease [CD]) were enrolled. Four hundred fifty-nine patients were naïve to anti-TNFα (group A), 196 had a previous exposure (group B), and the remaining 155 were switched to CT-P13 (group C)...
August 18, 2018: Inflammatory Bowel Diseases
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