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Inflammatory Bowel Diseases

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https://www.readbyqxmd.com/read/27893547/letters-to-the-editor
#1
Anita Afzali, Mika N Sinanan, Scott D Lee
No abstract text is available yet for this article.
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27893546/cutaneous-vasculitis-in-a-patient-with-crohn-s-disease-treated-with-adalimumab
#2
Didia B Cury, Alexandre W S de Souza, Giovanni A Vianna, Danilo Odashiro, Alex Farias, Alan C Moss
No abstract text is available yet for this article.
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27893545/effects-of-preoperative-methotrexate-on-complications-after-surgery-for-inflammatory-bowel-disease
#3
De-Jun Cui, Xiao-Lan Yang, Mei Hu, Liu-Chan Yang
No abstract text is available yet for this article.
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27893544/visceral-adiposity-genetic-susceptibility-and-risk-of-complications-among-individuals-with-crohn-s-disease
#4
Kimberley W J Van Der Sloot, Amit D Joshi, Danielle R Bellavance, Katherine K Gilpin, Kathleen O Stewart, Paul Lochhead, John J Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N Ananthakrishnan, Behrooz Z Alizadeh, Ramnik J Xavier, Hamed Khalili
INTRODUCTION: Adipose tissue in mesenteric fat plays a key role in systemic and luminal inflammation. However, little is known about the role of visceral adipose tissue (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. METHODS: Our study population included patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27893543/changes-in-intestinal-microbiota-following-combination-therapy-with-fecal-microbial-transplantation-and-antibiotics-for-ulcerative-colitis
#5
Dai Ishikawa, Takashi Sasaki, Taro Osada, Kyoko Kuwahara-Arai, Keiichi Haga, Tomoyoshi Shibuya, Keiichi Hiramatsu, Sumio Watanabe
BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM alone. METHODS: AFM therapy was administered to patients for 2 weeks until 2 days before FMT...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27849634/inflammation-and-apoptosis-dual-mediator-role-for-toll-like-receptor-4-in-the-development-of-necrotizing-enterocolitis
#6
Yin Zhou, Yibo Li, Bin Zhou, Keling Chen, Zhaoying Lyv, Dongmei Huang, Bin Liu, Zhicheng Xu, Bo Xiang, Shuguang Jin, Xiaofeng Sun, Yuan Li
BACKGROUND: Necrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal mortality; effective interventions are lacking with limited understanding of the pathogenesis of NEC. The importance of Toll-like receptor 4 (TLR4) signaling in NEC is well documented; however, the potential mechanisms that regulate enterocyte inflammation and apoptosis remain unclear. The aim of this study was to characterize the role of TLR4-mediated inflammation and apoptosis in the development of NEC and to determine the major apoptotic pathways and regulators in the process...
November 14, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27824649/downregulation-of-microrna-21-in-colonic-cd3-t-cells-in-uc-remission
#7
Yugo Ando, Luca Mazzurana, Marianne Forkel, Kazuichi Okazaki, Mamiko Aoi, Peter T Schmidt, Jenny Mjösberg, Francesca Bresso
BACKGROUND: In active inflammatory bowel disease (IBD), microRNA expression profiling consistently features disease-specific signatures, and microRNA-21 (miR-21) has been shown to be upregulated in the inflamed colon of patients with active ulcerative colitis (UC). However, the cellular sources of miR-21 expression in IBD tissues have not yet been identified. We sought to determine the expression levels of miR-21 and one of its downstream target genes, programmed cell death 4 (PDCD4), in CD3 T cells isolated from the colonic mucosa of patients with active IBD, inactive IBD, and non-IBD controls...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27824648/fecal-microbiota-and-metabolome-in-a-mouse-model-of-spontaneous-chronic-colitis-relevance-to-human-inflammatory-bowel-disease
#8
Ainsley M Robinson, Shakuntla V Gondalia, Avinash V Karpe, Rajaraman Eri, David J Beale, Paul D Morrison, Enzo A Palombo, Kulmira Nurgali
BACKGROUND: Dysbiosis of the gut microbiota may be involved in the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms underlying the role of the intestinal microbiome and metabolome in IBD onset and its alteration during active treatment and recovery remain unknown. Animal models of chronic intestinal inflammation with similar microbial and metabolomic profiles would enable investigation of these mechanisms and development of more effective treatments. Recently, the Winnie mouse model of colitis closely representing the clinical symptoms and characteristics of human IBD has been developed...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27824645/a-single-species-of-clostridium-subcluster-xiva-decreased-in-ulcerative-colitis-patients
#9
Kozue Takeshita, Shinta Mizuno, Yohei Mikami, Tomohisa Sujino, Keiichiro Saigusa, Katsuyoshi Matsuoka, Makoto Naganuma, Tadashi Sato, Toshihiko Takada, Hirokazu Tsuji, Akira Kushiro, Koji Nomoto, Takanori Kanai
BACKGROUND: Imbalance of the intestinal microbiota is associated with gastrointestinal disease and autoimmune disease and metabolic syndrome. Analysis of the intestinal microbiota has recently progressed, and the association with inflammatory bowel disease has been reported at the species level. Such findings suggest that the recovery of homeostasis in the intestinal microbiota could cure inflammatory bowel disease. We aimed to search new probiotic candidates for inflammatory bowel disease through translational research by analysis of ulcerative colitis (UC) patients' intestinal microbiota and clarify the effects of them on inflammation...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27779499/an-overview-of-the-innate-and-adaptive-immune-system-in-inflammatory-bowel-disease
#10
Matthew C Choy, Kumar Visvanathan, Peter De Cruz
Inflammatory bowel diseases (IBDs) are thought to develop as a result of complex interactions between host genetics, the immune system and the environment including the gut microbiome. Although an improved knowledge of the immunopathogenesis of IBDs has led to great advances in therapy such as the highly effective anti-tumor necrosis factor class of medications, a significant proportion of patients with Crohn's disease and ulcerative colitis do not respond to anti-tumor necrosis factor antibodies. Further understanding of the different immune pathways involved in the genesis of chronic intestinal inflammation is required to help find effective treatments for IBDs...
October 21, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27763952/factors-predicting-testing-and-treatment-of-iron-deficiency-in-a-nationwide-cohort-of-anemic-uc-patients
#11
Nabeel Khan, Dhruvan Patel, Yash Shah, Yu-Xiao Yang
BACKGROUND: Iron deficiency anemia (IDA) is an often unrecognized and undertreated complication of ulcerative colitis (UC). We conducted the first nationwide study in the United States to evaluate the prevalence of testing for iron deficiency (ID) in anemic UC patients and determine the frequency of treatment with iron supplementation in patients with IDA. METHODS: Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified...
October 18, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27763951/new-biomarkers-for-diagnosing-inflammatory-bowel-disease-and-assessing-treatment-outcomes
#12
Edward L Barnes, Robert Burakoff
Despite advances in our understanding of the pathophysiology underlying inflammatory bowel disease, there remains a significant need for biomarkers that can differentiate between Crohn's disease and ulcerative colitis with high sensitivity and specificity, in a cost-efficient manner. As the focus on personalized approaches to the delivery of medical treatment increases, new biomarkers are being developed to predict an individual's response to therapy and their overall disease course. In this review, we will outline many of the existing and recently developed biomarkers, detailing their role in the assessment of patients with inflammatory bowel disease...
October 18, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27755215/fecal-hmgb1-reveals-microscopic-inflammation-in-adult-and-pediatric-patients-with-inflammatory-bowel-disease-in-clinical-and-endoscopic-remission
#13
Francesca Palone, Roberta Vitali, Salvatore Cucchiara, Maurizio Mennini, Alessandro Armuzzi, Daniela Pugliese, Renata DʼIncà, Brigida Barberio, Laura Stronati
BACKGROUND: Fecal high mobility group box 1 (HMGB1) has been suggested to be a novel noninvasive biomarker of gut inflammation. We aimed to assess the reliability of fecal HMGB1, compared with fecal calprotectin (FC), in detecting intestinal inflammation in pediatric and adult patients with inflammatory bowel disease (IBD) and to evaluate the accuracy of HMGB1 in identifying patients with IBD in clinical and endoscopic remission who still have histologic features of inflammation. METHODS: Stool samples from 85 children with IBD (49 Crohn's disease [CD] and 36 ulcerative colitis [UC] and 119 adults [57 Crohn's disease and 62 ulcerative colitis]) were analyzed for the study...
October 13, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27755214/incidence-of-bowel-surgery-and-associated-risk-factors-in-pediatric-onset-crohn-s-disease
#14
Firas Rinawi, Amit Assa, Corina Hartman, Yael Mozer Glassberg, Vered Nachmias Friedler, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
BACKGROUND: Data describing the incidence and the risk factors for surgical interventions in pediatric Crohn's disease (CD) is inconsistent. Our aim was to describe the rates of intestinal surgery and to identify associated risk factors in a large cohort of children with CD. METHODS: Medical charts of 482 children with CD from the Schneider Pediatric Inflammatory Bowel Disease cohort who were diagnosed between 1981 and 2013 were carefully reviewed retrospectively...
October 13, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27755216/altered-prostasin-cap1-prss8-expression-favors-inflammation-and-tissue-remodeling-in-dss-induced-colitis
#15
Anna Keppner, Sumedha Malsure, Antoine Nobile, Muriel Auberson, Olivier Bonny, Edith Hummler
BACKGROUND: Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are diseases with impaired epithelial barrier function. We aimed to investigate whether mutated prostasin and thus, reduced colonic epithelial sodium channel activity predisposes to develop an experimentally dextran sodium sulfate (DSS)-induced colitis. METHODS: Wildtype, heterozygous (fr/+), and homozygous (fr/fr) prostasin-mutant rats were treated 7 days with DSS followed by 7 days of recovery and analyzed with respect to histology, clinicopathological parameters, inflammatory marker mRNA transcript expression, and sodium transporter protein expression...
October 12, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27749376/assessment-of-gaps-in-care-and-the-development-of-a-care-pathway-for-anemia-in-patients-with-inflammatory-bowel-diseases
#16
Jason K Hou, Christoph Gasche, Noam Z Drazin, Sarah Alandra Weaver, Orna G Ehrlich, Ridhima Oberai, Sophie Zapala, Corey A Siegel, Gil Melmed
BACKGROUND: Anemia is a common complication among patients with inflammatory bowel diseases (IBD) and is associated with high rates of IBD-related complications, resource utilization, and impaired quality of life. Despite practice guidelines for anemia in patients with IBD, gaps remain in the perceptions of anemia among health care providers. The aims of this study were to identify gaps in care and to develop a care pathway for anemia in patients with IBD. METHODS: The Crohn's & Colitis Foundation of America anemia care pathway was developed by a committee using principles of cognitive task analysis...
September 30, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27661670/letters-to-the-editor
#17
Sunanda V Kane
No abstract text is available yet for this article.
September 21, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27661668/colonic-lamina-propria-inflammatory-cells-from-patients-with-ibd-induce-the-nuclear-factor-e2-related-factor-2-thereby-leading-to-greater-proteasome-activity-and-apoptosis-protection-in-human-colonocytes
#18
Marie-Luise Kruse, Martin Friedrich, Alexander Arlt, Christoph Röcken, Jan-Hendrik Egberts, Susanne Sebens, Heiner Schäfer
BACKGROUND: The antioxidant transcription factor Nrf2 confers broad cytoprotection and has a dual role in tumorigenesis. Enhancing proteasome activity is one mechanism by which Nrf2 can promote cancer development, e.g., colorectal cancer. This study investigated whether this potential oncogenic effect of Nrf2 emerges already from the epithelial adaptation to persistent oxidative stress during inflammatory bowel disease (IBD). METHODS: Reactive oxygen species (ROS)-producing inflammatory myeloid cells (IMCs) from colon tissue of patients with IBD were cocultured with human NCM460 colonocytes...
September 21, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27661667/effect-of-long-noncoding-rna-h19-overexpression-on-intestinal-barrier-function-and-its-potential-role-in-the-pathogenesis-of-ulcerative-colitis
#19
Shan-Wen Chen, Peng-Yuan Wang, Yu-Cun Liu, Lie Sun, Jing Zhu, Shuai Zuo, Ju Ma, Teng-Yu Li, Jun-Ling Zhang, Guo-Wei Chen, Xin Wang, Qiu-Ru Zhu, You-Wen Zheng, Ze-Yang Chen, Zi-Hao Yao, Yi-Sheng Pan
BACKGROUND: Recently, long noncoding RNA (lncRNA) H19 has been reported to be related with VDR signaling and the development of inflammatory diseases including osteoarthritis. The aim of this study was to investigate the correlation between the expression level of H19 and VDR in ulcerative colitis (UC) tissues and to investigate the effect of H19 overexpression on intestinal epithelial barrier function. METHODS: The expression level of H19, miR-675-5p, and VDR in UC tissues and paired normal tissues collected from 12 patients with UC was investigated by quantitative real-time polymerase chain reaction...
September 21, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27636380/distinct-anti-ifi16-and-anti-gp2-antibodies-in-inflammatory-bowel-disease-and-their-variation-with-infliximab-therapy
#20
Valeria Caneparo, Luca Pastorelli, Laura Francesca Pisani, Barbara Bruni, Flavia Prodam, Renzo Boldorini, Dirk Roggenbuck, Maurizio Vecchi, Santo Landolfo, Marisa Gariglio, Marco De Andrea
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the expression and function of pattern recognition receptors, including the IFI16 protein. Because this protein is a target for autoantibodies and its aberrant expression was reported in colonic mucosa from active patients with ulcerative colitis, we studied its expression and specific seroresponse in patients with IBD before and after infliximab (IFX) therapy...
September 15, 2016: Inflammatory Bowel Diseases
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