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Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]

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https://www.readbyqxmd.com/read/30306206/a-review-of-inflammatory-mechanism-in-airway-diseases
#1
REVIEW
Parya Aghasafari, Uduak George, Ramana Pidaparti
BACKGROUND: Inflammation in the lung is the body's natural response to injury. It acts to remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the healing process. Acute and chronic pulmonary inflammation are seen in different respiratory diseases such as; acute respiratory distress syndrome, chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis (CF). FINDINGS: In this review, we found that inflammatory response in COPD is determined by the activation of epithelial cells and macrophages in the respiratory tract...
October 10, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30288556/c-reactive-protein-as-a-biomarker-of-severe-h1n1-influenza
#2
REVIEW
Denitsa Vasileva, Alaa Badawi
BACKGROUND: C-reactive protein (CRP) is an acute-phase reactant downstream of the pro-inflammatory cytokines released during influenza infection. However, the role of this inflammatory marker in influenza severity and complications is yet to be elucidated. OBJECTIVES: We aim to systematically review and evaluate the levels of CRP in severe and non-severe H1N1 influenza cases and assess its utility as a biomarker in predicting the severity of infection. METHODS: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of Print, Embase and Embase Classic to identify human studies reporting measurements of CRP levels in patients infected with H1N1 influenza at various levels of disease severity...
October 4, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30276649/pre-eclampsia-the-role-of-highly-active-antiretroviral-therapy-and-immune-markers
#3
REVIEW
Wendy N Phoswa, Thajasvarie Naicker, Veron Ramsuran, Jagidesa Moodley
PURPOSE OF THE REVIEW: This review highlights the role immune cells and markers such as natural killer (NK) cells, cytokines and human leukocyte antigen (HLA-G) play in predisposing HIV-infected women who are on HAART to develop PE, thus contributing to a better understanding and early diagnosis of PE with a subsequent reduction in maternal foetal and neonatal deaths. RECENT FINDINGS: Pregnant women infected with the Human Immunodeficiency Virus (HIV) have a 25% risk of mother to child transmission...
October 1, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30178100/a-comprehensive-review-on-the-treatment-approaches-of-multiple-sclerosis-currently-and-in-the-future
#4
REVIEW
Mehrdad Gholamzad, Masoumeh Ebtekar, Mehdi Shafiee Ardestani, Maryam Azimi, Zeinab Mahmodi, Mohammad Javad Mousavi, Saeed Aslani
BACKGROUND: Multiple sclerosis (MS) is a chronic and autoimmune disease of the central nervous system (CNS), mainly characterized by inflammatory demyelination, which manifests as relapses and diffuse damage and brain volume loss, both accounting for neurodegeneration, and therefore, physical disability. MS typically affects young adults and is commonly diagnosed in the early years by acute relapses, which then followed through partial or complete remission period. The clinical course of MS is characterized as four major classifications, including relapsing-remitting (RRMS), primary progressive (PPMS), progressive relapsing (PRMS), and secondary progressive (SPMS)...
September 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30155690/altered-regulation-of-the-t-cell-system-in-patients-with-crps
#5
Jens Heyn, Shahnaz C Azad, Benjamin Luchting
The aim of this study was to investigate T-cell subsets and immunomodulatory factors in patients with complex regional pain syndrome (CRPS). We found decreased numbers of pro-inflammatory Th17 cells in patients with CRPS as compared to healthy volunteers. The expression of Th17 related RORγT mRNA was also significantly decreased. Patients with CRPS showed an increased proportion of CD39+ Tregs. CD39 is a known inhibitor of Th17 cell differentiation. Systemic cytokine levels were almost unchanged in patients with CRPS...
August 28, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30132016/cross-talk-between-natural-killer-cells-and-mast-cells-in-tumor-angiogenesis
#6
REVIEW
Domenico Ribatti, Roberto Tamma, Enrico Crivellato
Natural killer (NK) cells are large granular lymphocytes of the innate immune system, responsible for direct targeting and killing of both virally infected and transformed cells. Under pathological conditions and during inflammation, NK cells extravasate into the lymph nodes and accumulate at inflammatory or tumor sites. The activation of NK cells depends on an intricate balance between activating and inhibitory signals that determines if a target will be susceptible to NK-mediated lysis. Many experimental evidences indicate that NK cells are also involved in several immunoregulatory processes and have the ability to modulate the adaptive immune responses...
August 21, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30121835/metabolites-of-prostaglandin-synthases-as-potential-biomarkers-of-lyme-disease-severity-and-symptom-resolution
#7
REVIEW
Alicia Caroline Jarosz, Alaa Badawi
BACKGROUND: Lyme disease or Lyme borreliosis (LB) is the commonest vector-borne disease in the North America. It is an inflammatory disease caused by the bacterium Borrelia burgdorferi. The role of the inflammatory processes mediated by prostaglandins (PGs), thromboxanes and leukotrienes (LTs) in LB severity and symptoms resolution is yet to be elucidated. OBJECTIVES: We aim to systematically review and evaluate the role of PGs and related lipid mediators in the induction and resolution of inflammation in LB...
August 18, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30370484/naringenin-mitigates-titanium-dioxide-tio-2-induced-chronic-arthritis-in-mice-role-of-oxidative-stress-cytokines-and-nf%C3%AE%C2%BAb
#8
Marília F Manchope, Nayara A Artero, Victor Fattori, Sandra S Mizokami, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Thiago M Cunha, José C Alves-Filho, Fernando Q Cunha, Rubia Casagrande, Waldiceu A Verri
OBJECTIVE: To evaluate the effect and mechanisms of naringenin in TiO2 -induced chronic arthritis in mice, a model resembling prosthesis and implant inflammation. TREATMENT: Flavonoids are antioxidant and anti-inflammatory molecules with important anti-inflammatory effect. Mice were daily treated with the flavonoid naringenin (16.7-150 mg/kg, orally) for 30 days starting 24 h after intra-articular knee injection of 3 mg of TiO2 . METHODS: TiO2 -induced arthritis resembles cases of aseptic inflammation induced by prosthesis and/or implants...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30334065/microrna-429-regulates-the-expression-of-chmp5-in-the-inflammatory-colitis-and-colorectal-cancer-cells
#9
Ji-Su Mo, Seol-Hee Han, Ki-Jung Yun, Soo-Cheon Chae
OBJECTIVE AND DESIGN: MicroRNAs (miRNAs) play an important role in the pathogenesis of human diseases by regulating the expression of target genes in specific cells or tissues. In this study, we analyzed the association between the MIR429 and its target gene, charged multivesicular body protein 5 (CHMP5), in human colon cancer cells and in a DSS-induced colitis mouse model. MATERIALS AND METHODS: A luciferase reporter system was used to confirm the effect of MIR429 on CHMP5 expression...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30328477/pka-regulates-hmgb1-through-activation-of-igfbp-3-and-sirt1-in-human-retinal-endothelial-cells-cultured-in-high-glucose
#10
Li Liu, Paragi Patel, Jena J Steinle
OBJECTIVE AND DESIGN: Inflammation is a key component of a number of diseases, including diabetic retinopathy. We investigated the cellular pathway by which protein kinase A (PKA) inhibited high mobility group box 1 (HMGB1). METHODS: Primary human retinal endothelial cells (REC) were grown in normal glucose (5 mM) or high glucose (25 mM). Cells in high glucose were treated with exchange protein for cAMP 1 (Epac1) and IGFBP-3 siRNA. Additional cells in high glucose were treated with forskolin, a PKA agonist, and Epac1 siRNA...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30317465/using-human-ips-cell-derived-enterocytes-as-novel-in-vitro-model-for-the-evaluation-of-human-intestinal-mucosal-damage
#11
Satoshi Kondo, Shota Mizuno, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga
OBJECTIVE AND DESIGN: The primary component in gut mucus is mucin 2 (MUC2) secreted by goblet cells. Fluctuations in MUC2 expression are considered a useful indicator for evaluating mucosal damage and protective effect of various agents using animal studies. However, there are few in vitro studies evaluating mucosal damage using MUC2 as the indicator. Hence, we attempted to establish a novel in vitro model with MUC2 as the indicator for evaluating drug-induced mucosal damage and protective effect using enterocytes derived from human iPS cells...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30310931/lncrna-meg3-impacts-proliferation-invasion-and-migration-of-ovarian-cancer-cells-through-regulating-pten
#12
Juelan Wang, Wenqian Xu, Yangke He, Qi Xia, Siwei Liu
OBJECTIVE AND DESIGN: We investigated the expressions of lncRNA MEG3 and PTEN in ovarian cancer tissues and their effects on cell proliferation, cycle and apoptosis of ovarian cancer. METHODS: Expression levels of MEG3 in ovarian cancer cell lines and normal ovarian cell lines were detected by qRT-PCR. Cell viability was detected by MTT assay. Cell apoptosis and cell cycle distribution were measured by flow cytometry. Cell invasion capability was tested by transwell assay...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30306207/mir-200b-attenuates-il-6-production-through-ikk%C3%AE-and-zeb1-in-human-gingival-fibroblasts
#13
Sari Matsui, Liming Zhou, Yohei Nakayama, Masaru Mezawa, Ayako Kato, Naoto Suzuki, Natsuko Tanabe, Tomohiro Nakayama, Yuki Suzuki, Noriaki Kamio, Hideki Takai, Yorimasa Ogata
OBJECTIVE: MicroRNAs (miRNAs) play important roles in biological processes such as cell differentiation, development, infection, immune response, inflammation and tumorigenesis. We previously reported that the expression of miR-200b was significantly increased in inflamed gingiva compared with non-inflamed gingiva. To elucidate the roles of miR-200b in the inflamed gingiva, we have analyzed the effects of miR-200b on the expression of IL-6 in human gingival fibroblasts (HGF). MATERIALS AND METHODS: Total RNA and protein were extracted from HGF after stimulation by interleukin-1β (IL-1β; 1 ng/ml) or tumor necrosis factor-α (TNF-α; 10 ng/ml) and transfected with miR-200b expression plasmid or miR-200b inhibitor...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30291375/tetraspanin-1-inhibits-tnf%C3%AE-induced-apoptosis-via-nf-%C3%AE%C2%BAb-signaling-pathway-in-alveolar-epithelial-cells
#14
Lawei Yang, Yahong Wang, Zhanchun Pan, Shenglan Gao, Bao'an Zou, Ziying Lin, Dehui Feng, Changmei HuangFu, Gang Liu
OBJECTIVE: Tetraspanin family plays an important role in the pathogenesis of cancer, but its role in lung fibrosis is unknown. To determine whether tetraspanin 1 (TSPAN1), a member of the family, may be involved in the pathogenesis of pulmonary fibrosis. METHODS: TNFα -stimulated human alveolar epithelial (A549) and alveolar epithelial type II cell (AT2) were treated in vitro. Murine pulmonary fibrosis model was generated by injection of bleomycin (BLM). The expression of TSPAN1 was examined in vivo using the bleomycin-induced lung fibrosis model and tissue sample of IPF patients...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30229393/s100b-promotes-microglia-m1-polarization-and-migration-to-aggravate-cerebral-ischemia
#15
Saijun Zhou, Weiqian Zhu, Yang Zhang, Sipei Pan, Jianhong Bao
AIM AND OBJECTIVE: S100B has been found abundantly expressed in microglia during cerebral ischemia. However, S100B effects on phenotype changes and migration of microglia are unclear. METHODS: Real-time PCR of S100B, M1 and M2 markers were tested to characterize phenotypic changes in microglia in mice middle cerebral artery occlusion (MCAO) model. Migration assay and additional mechanism studies were performed to elucidate the role of NF-κB in S100B-mediated microglia M1/M2 phenotype change and migration...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30151700/long-noncoding-rna-malat1-acts-as-a-competing-endogenous-rna-to-regulate-amadori-glycated-albumin-induced-mcp-1-expression-in-retinal-microglia-by-a-microrna-124-dependent-mechanism
#16
Ning Dong, Bing Xu, Hong Shi
OBJECTIVE: To determine whether the long noncoding RNA MALAT1 may be involved in the inflammatory effect of Amadori-glycated albumin (AGA) in retinal microglia via a microRNA-124 (miR-124)-dependent mechanism. METHODS: Diabetes mellitus was induced by streptozotocin (STZ) injection. The expression of monocyte chemotactic protein-1 (MCP-1) in the retinas of rats was determined using quantitative reverse transcription-PCR (qRT-PCR) analyses and enzyme-linked immunosorbent assay (ELISA)...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30145653/nuciferine-alleviates-lps-induced-mastitis-in-mice-via-suppressing-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#17
Xingxing Chen, Xintian Zheng, Min Zhang, Huifang Yin, Kangfeng Jiang, Haichong Wu, Ailing Dai, Shoushen Yang
BACKGROUND: Nuciferine, a major bioactive component from the lotus leaf, has been reported to have notable anti-inflammatory activities such as renal inflammation and acute lung injury in previous studies. Mastitis is one of the most prevalent diseases in the dairy cattle, which causes large economic losses for the dairy industry. However, the effects of nuciferine on lipopolysaccharide (LPS)-induced mastitis have not been reported. METHODS AND RESULTS: Here, we investigated the anti-inflammatory effects of nuciferine on LPS-induced mastitis in mice and illuminated its potential mechanism on the TLR4-mediated signaling pathway in mouse mammary epithelial cells (mMECs)...
December 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30136196/lysosomal-membrane-permeabilization-causes-secretion-of-il-1%C3%AE-in-human-vascular-smooth-muscle-cells
#18
Hiroaki Ono, Ryo Ohta, Yuri Kawasaki, Akira Niwa, Hidetoshi Takada, Tatsutoshi Nakahata, Shouichi Ohga, Megumu K Saito
OBJECTIVE: IL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and generally acts as an activating signal. However, the role of LMP controlling NLRP3 inflammasome activation in human vascular smooth muscle cells (hVSMCs) is not well defined. METHODS: LMP was induced in hVSMCs by Leu-Leu-O-methyl ester...
October 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30121836/micronized-palmitoylethanolamide-reduces-joint-pain-and-glial-cell-activation
#19
Maria Lavinia Bartolucci, Ida Marini, Francesco Bortolotti, Daniela Impellizzeri, Rosanna Di Paola, Giuseppe Bruschetta, Rosalia Crupi, Marco Portelli, Angela Militi, Giacomo Oteri, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: Temporomandibular disorder (TMD) is a common painful condition in the temporomandibular joint (TMJ). Joint inflammation is believed to be a chief cause of pain in patients with TMD, through the release of pro-inflammatory cytokines that induce peripheral sensitization of nerve terminals followed by microglial stimulation. MATERIALS AND SUBJECT: TMJ was induced in rats with the injection of complete Freund's adjuvant (CFA) emulsion into the left TMJ capsule...
October 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30109356/quetiapine-ameliorates-collagen-induced-arthritis-in-mice-via-the-suppression-of-the-akt-and-erk-signaling-pathways
#20
Yi-Ju Pan, Wei-Hsun Wang, Tzu-Yao Huang, Wei-Hsiang Weng, Chun-Kai Fang, Yu-Chan Chen, Jeng-Jong Hwang
OBJECTIVE AND DESIGN: To investigate the amelioration effects of quetiapine on rheumatoid arthritis with RAW 264.7 macrophage and collagen-induced arthritis (CIA) DBA/1J mouse model. SUBJECTS: RAW 264.7 macrophage and DBA/1J mice. TREATMENT: Lipopolysaccharide and collagen. METHODS: RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS) followed by quetiapine treatments were investigated. Activations of CD80 and CD86 were analyzed by flow cytometry...
October 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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