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Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]

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https://www.readbyqxmd.com/read/29786779/dnmt3a-controls-mir-200b-in-cardiac-fibroblast-autophagy-and-cardiac-fibrosis
#1
Xu-Dong Zhao, Run-He Qin, Jing-Jing Yang, Sheng-Song Xu, Hui Tao, Xuan-Sheng Ding, Kai-Hu Shi
AIM AND OBJECTIVE: Regulation of microRNA gene expression by DNA methylation may represent a key mechanism to drive cardiac fibrosis progression. Cardiac fibroblast autophagy is the primary source of cardiac fibrosis, but the mechanisms underlying this process are incompletely understood. Here we found that DNMT3A suppression of the microRNA-200b (miR-200b) through pathway leads to cardiac fibroblast autophagy in cardiac fibrosis. METHODS: To understand the impact of DNMT3A on miR-200b at cardiac fibrosis, the rat cardiac fibrosis model was established via the abdominal aortic coarctation...
May 21, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29774370/il-33-s-st2-ratio-systemic-symptoms-and-basophil-activation-in-pru-p-3-sensitized-allergic-patients
#2
Carina G Uasuf, Caterina Di Sano, Sebastiano Gangemi, Giuseppe Albeggiani, Diego Cigna, Paola Dino, Ignazio Brusca, Mark Gjomarkaj, Elisabetta Pace
BACKGROUND: Although IL-33/ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. METHODS: In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensitized allergic patients (SAP), and in 68 non-Pru p 3-SAP. Basophil activation test (BAT) was used to assess the basophil activation due to allergen exposure before and after the addition of s-ST2 to the blood samples from 5 Pru p 3-SAP...
May 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29767332/recent-development-in-antihyperalgesic-effect-of-phytochemicals-anti-inflammatory-and-neuro-modulatory-actions
#3
REVIEW
Ajeet Kumar Singh, Sanjay Kumar, Manjula Vinayak
INTRODUCTION: Pain is an unpleasant sensation triggered by noxious stimulation. It is one of the most prevalent conditions, limiting productivity and diminishing quality of life. Non steroidal anti inflammatory drugs (NSAIDs) are widely used as pain relievers in present day practice as pain is mostly initiated due to inflammation. However, due to potentially serious side effects, long term use of these antihyperalgesic drugs raises concern. Therefore there is a demand to search novel medicines with least side effects...
May 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29766204/adiponectin-administration-alleviates-dss-induced-colonic-inflammation-in-caco-2-cells-and-mice
#4
Qin Zhao, Yang Liu, Lei Tan, Liyong Yan, Xiuli Zuo
BACKGROUND: Adiponectin, a protein hormone produced by adipose tissues, exhibits anti-inflammatory functions in various models. This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in Caco-2 cell and mice. MATERIALS AND METHODS: The results showed that DSS caused inflammatory response and intestinal barrier dysfunction in vitro and in vivo. Adiponectin injection alleviated colonic injury and rectal bleeding in mice...
May 15, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29754263/genes-and-their-single-nucleotide-polymorphism-involved-in-innate-immune-response-in-central-nervous-system-in-bacterial-meningitis-review-of-literature-data
#5
REVIEW
Ewelina Gowin, Danuta Januszkiewicz-Lewandowska
BACKGROUND: There are many studies analysing the effect of SNPs in genes coding proteins which are involved in innate immune response on susceptibility to invasive bacterial disease. Many of them gave inconclusive results. Regarding the complexity of immune response and cooperation between particular elements, number of SNPs may have a cumulative effect on the susceptibility to bacterial meningitis. FINDINGS: In most studies cooccurrence of several SNPs was not analysed...
May 12, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29725698/scarf1-a-multifaceted-yet-largely-understudied-scavenger-receptor
#6
REVIEW
Daniel A Patten
BACKGROUND: As is a prerequisite of belonging to the scavenger receptor super family, SCARF1 (scavenger receptor class F, member 1) is known to play a key role in the binding and endocytosis of a wide range of endogenous and exogenous ligands. FINDINGS: Unlike most scavenger receptors, SCARF1 is an essential protein, as SCARF1-deficient mice exhibit a severe resting phenotype in which they develop systemic lupus erythematosus (SLE)-like disease, thus highlighting the importance of SCARF1-mediated clearance of apoptotic host cells in homeostasis...
May 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29713730/prostaglandin-e2-and-il-23-interconnects-stat3-and-ror%C3%AE-pathways-to-initiate-th17-cd4-t-cell-development-during-rheumatoid-arthritis
#7
REVIEW
Janaiya S Samuels, Lauren Holland, María López, Keya Meyers, William G Cumbie, Anna McClain, Aleksandra Ignatowicz, Daryllynn Nelson, Rangaiah Shashidharamurthy
BACKGROUND: The chronic inflammation associated with rheumatoid arthritis (RA) leads to focal and systemic bone erosion of the joints resulting in a crippling disability. Recent reports indicate an increase in the incidence of RA in the coming years, placing a significant burden on healthcare resources. The incidence of RA is observed to be increasing with age and a significant proportion of those new cases will be aggressively erosive. FINDINGS: The altered physiology, due to immune disturbances, contributes towards RA pathogenesis...
April 30, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29693710/a-review-on-heme-oxygenase-1-induction-is-it-a-necessary-evil
#8
REVIEW
Ajaz Ahmad Waza, Zeenat Hamid, Sajad Ali, Shabir Ahmad Bhat, Musadiq Ahmad Bhat
Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising as a result of oxidative and inflammatory insults. Tremendous research has been carried out on HO-1 since years, pertaining its cytoprotective effect against oxidative injury and other cellular stresses. HO-1, by regulating intracellular levels of pro-oxidant heme, or by other benefits of its by-products such as carbon monoxide (CO) and biliverdin (BV) had become an important candidate protein to be up-regulated to combat diverse stressful events...
April 24, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29687146/genistein-modulates-the-expression-of-toll-like-receptors-in-experimental-autoimmune-encephalomyelitis
#9
Alyria Teixeira Dias, Sandra Bertelli Ribeiro de Castro, Caio César de Souza Alves, Marcilene Gomes Evangelista, Luan Cristian da Silva, Daniele Ribeiro de Lima Reis, Marco Antonio Machado, Maria Aparecida Juliano, Ana Paula Ferreira
OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s...
April 23, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29679313/effects-of-different-natural-extracts-in-an-experimental-model-of-benign-prostatic-hyperplasia-bph
#10
Irene Paterniti, Michela Campolo, Marika Cordaro, Rosalba Siracusa, Antonio Filippone, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target. MATERIAL: BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. TREATMENT: Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28...
April 20, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29644420/soluble-trem-1-as-a-predictive-factor-of-neonatal-sepsis-a-meta-analysis
#11
REVIEW
Ioannis Bellos, Georgia Fitrou, Georgios Daskalakis, Nikolaos Thomakos, Nikolaos Papantoniou, Vasilios Pergialiotis
BACKGROUND: The efficacy of soluble triggering receptor expressed on myeloid cell-1 (TREM-1) in detecting sepsis in adults has already been proven. To date, however, consensus in the field of neonatal sepsis is lacking. The purpose of the present systematic review is to accumulate current evidence in this field. SEARCH STRATEGY: We systematically searched Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) and Google Scholar (2004-2017) along with reference lists from included studies...
April 11, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29632956/expression-analysis-of-toll-like-receptors-of-dengue-infected-cornea-by-real-time-polymerase-chain-reaction
#12
Durgadevi Parthasarathy, Janani Krishnan Madhuravasal, Padmapriya Jayavel, Lily Therese Kulandai, Madhavan Hajib Narahari Rao, Malathi Jambulingam
BACKGROUND: Toll-like receptors (TLRs) play a significant role based on innate immune mechanism during viral infection. TLR signaling mechanism designates to protect the cells from invading viruses. The expression of TLRs during dengue virus (DENV) infection not yet well explained. This study evaluates the TLR gene expression from DENV-infected patient's cornea. METHODS: Reverse transcriptase PCR was performed for the detection and genotyping of viral nucleic acid from corneal grafts and DENV-infected cell suspension...
April 9, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29616282/a-large-lung-gene-expression-study-identifying-il1b-as-a-novel-player-in-airway-inflammation-in-copd-airway-epithelial-cells
#13
Gao Yi, Min Liang, Ming Li, Xiangming Fang, Jifang Liu, Yuxiong Lai, Jitao Chen, Wenxia Yao, Xiao Feng, La Hu, Chunyi Lin, Xinke Zhou, Zhaoyu Liu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic and progressive lung disease characterized by a mixture of small airway disease and lung tissue parenchymal destruction. Abnormal inflammatory responses to cigarette smoking and other noxious particles are generally thought to be responsible for causing of COPD. Since airway inflammation is a key factor in COPD progress, it is crucial to unravel its underlying molecular mechanisms. Unbiased analysis of genome-wide gene expression profiles in lung small airway epithelial cells provides a powerful tool to investigate this...
April 3, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29610934/il-33-attenuates-mortality-by-promoting-ifn-%C3%AE-production-in-sepsis
#14
Qi Bao, Ran Lv, Min Lei
OBJECTIVE AND DESIGN: Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated. MATERIALS AND METHODS: We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment. RESULTS: IL-33 treatment enhanced the IFN-γ level in blood and promoted mice's survival, so the protective effects of IL-33 depend on IFN-γ...
April 2, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29605872/biological-therapy-downregulates-the-heterodimer-s100a8-a9-calprotectin-expression-in-psoriatic-patients
#15
F D'Amico, M Granata, E Skarmoutsou, C Trovato, G Lovero, P Gangemi, V Longo, M Pettinato, M C Mazzarino
The pathophysiology of psoriasis is very complex and involves an interplay between immune cells and keratinocytes. The keratinocyte production of calprotectin (S100A8/A9), induced by the inflammatory psoriatic milieu, may be involved in initiating immune cell invasion, as well as in propagating inflammation. However, the exact role of calprotectin in psoriasis remains unclear. Therapeutic approaches utilizing adalimumab, etanercept and ustekinumab are widely used in psoriatic treatment, but their anti-inflammatory mechanisms are not fully understood...
March 31, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29600327/the-histamine-h4-receptor-modulates-the-differentiation-process-of-human-monocyte-derived-m1-macrophages-and-the-release-of-ccl4-mip-1%C3%AE-from-fully-differentiated-m1-macrophages
#16
Susanne Mommert, Lisanne Ratz, Holger Stark, Ralf Gutzmer, Thomas Werfel
OBJECTIVE: Histamine is an important mediator of biological functions and present in high amounts in inflammatory skin lesions which are characterised by a marked infiltration of myeloid derived cell populations. The aim of the study was to investigate the expression and function of histamine receptors, with a focus on the histamine H4 receptor (H4R) in detail during the differentiation process from monocytes to macrophages and on fully differentiated M1 macrophages. METHODS: Quantitative PCR, ELISA technique, and flow cytometry were applied to analyze expression levels of histamine receptors, of CXCL10, CCL4, CCL3, or IL-23 and of the macrophage differentiation marker CD68, respectively...
March 29, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29589052/the-nitrone-spin-trap-5-5-dimethyl-1-pyrroline-n-oxide-dampens-lipopolysaccharide-induced-transcriptomic-changes-in-macrophages
#17
M D Muñoz, M C Della Vedova, P R Bushel, D Ganini da Silva, R P Mason, Z Zhai, S E Gomez Mejiba, D C Ramirez
OBJECTIVE: M1-like inflammatory phenotype of macrophages plays a critical role in tissue damage in chronic inflammatory diseases. Previously, we found that the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) dampens lipopolysaccharide (LPS)-triggered inflammatory priming of RAW 264.7 cells. Herein, we tested whether DMPO by itself can induce changes in macrophage transcriptome, and that these effects may prevent LPS-induced activation of macrophages. MATERIALS AND METHODS: To test our hypothesis, we performed a transcriptomic and bioinformatics analysis in RAW 264...
March 27, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29582093/inflammation-a-significant-player-of-ataxia-telangiectasia-pathogenesis
#18
REVIEW
Majid Zaki-Dizaji, Seyed Mohammad Akrami, Gholamreza Azizi, Hassan Abolhassani, Asghar Aghamohammadi
INTRODUCTION: Ataxia-Telangiectasia (A-T) syndrome is an autosomal recessive neurodegenerative disorder characterized by cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, chromosome instability, radiosensitivity, and predisposition to malignancy. There is growing evidence that A-T patients suffer from pathologic inflammation that is responsible for many symptoms of this syndrome, including neurodegeneration, autoimmunity, cardiovascular disease, accelerated aging, and insulin resistance...
March 26, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29574480/author-correction-pkc-dependent-phosphorylation-of-munc18a-at-ser313-in-activated-rbl-2h3-cells
#19
Pratikshya Adhikari, Hao Xu
Acknowledgements This work was supported by the University of Southern Mississippi Development Grant DE01475, the National Institute of Allergy and Infectious Diseases Grant 1R15AI133430-01, and by the Mississippi INBRE, which was funded by an Institutional Development Award (IDeA) from NIGMS under Grant no. P20GM103476.
March 24, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29541795/the-role-of-lymphotoxin-%C3%AE-in-rheumatoid-arthritis
#20
REVIEW
Tomohiro Hirose, Yuri Fukuma, Ayumu Takeshita, Keiichiro Nishida
BACKGROUND: The role of tumor necrosis factor (TNF) in the inflammatory response in rheumatoid arthritis (RA) is well established, whereas less is known about the role of TNF's close homolog, lymphotoxin alpha (LTα). FINDINGS: Increased levels of LTα are found in the serum and synovial tissue of patients with RA, and in vitro studies found that LTα-induced proliferation of RA fibroblast-like synoviocytes was at a similar level to TNF. These findings support the idea that anti-LTα treatment could be beneficial in patients with RA, but pateclizumab, an anti-LTα antibody, was not as efficacious as the anti-TNF agent adalimumab in reducing symptoms of RA in a head-to-head study, suggesting that anti-LTα therapies might not represent a valid alternative treatment option in patients with RA...
June 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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