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Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]

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https://www.readbyqxmd.com/read/29340705/author-correction-ouabain-attenuates-ovalbumin-induced-airway-inflammation
#1
José Guilherme F M Galvão, Luiz Henrique Agra Cavalcante-Silva, Deyse Cristina M Carvalho, Laércia Karla D P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Larissa Adiles M P Ferreira, Francisco Allysson A F Gadelha, Marcia Regina Piuvezam, Sandra Rodrigues-Mascarenhas
In the original publication, author missed to include the financial support from CAPES/PROCAD-2013. The complete funding text should read as follows.
January 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29322204/evolving-notions-on-immune-response-in-colorectal-cancer-and-their-implications-for-biomarker-development
#2
REVIEW
Fabio Grizzi, Gianluca Basso, Elena Monica Borroni, Tommaso Cavalleri, Paolo Bianchi, Sanja Stifter, Maurizio Chiriva-Internati, Alberto Malesci, Luigi Laghi
INTRODUCTION: Colorectal cancer (CRC) still represents the third most commonly diagnosed type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous disease that develops through a multi-step sequence of events driven by clonal selections; this observation is sustained by the fact that histologically similar tumors may have completely different outcomes, including a varied response to therapy. METHODS: In "early" and "intermediate" stage of CRC (stages II and III, respectively) there is a compelling need for new biomarkers fit to assess the metastatic potential of their disease, selecting patients with aggressive disease that might benefit from adjuvant and targeted therapies...
January 10, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29302720/anti-inflammatory-effect-and-mechanism-of-the-spirocyclopiperazinium-salt-compound-lxm-15-in-rats-and-mice
#3
Xiaoli Gao, Qi Sun, Weiwei Zhang, Yimin Jiang, Runtao Li, Jia Ye
OBJECTIVE: This study aimed to investigate the anti-inflammatory effects of a novel spirocyclopiperazinium salt compound LXM-15, and explore the underlying mechanisms. METHODS: Xylene-induced mouse ear oedema and carrageenan-induced rat paw oedema tests were used to evaluate the anti-inflammatory effects of LXM-15. The protein levels of TNF-α, IL-6, phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) were detected by ELISA or Western blot analysis...
January 4, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29288273/pro-inflammatory-cytokines-after-an-episode-of-acute-pancreatitis-associations-with-fasting-gut-hormone-profile
#4
Sayali A Pendharkar, Ruma G Singh, Shayal K Chand, Aya Cervantes, Maxim S Petrov
INTRODUCTION: Pro-inflammatory cytokines, such as interleukin (IL)-6, tumour necrosis factor (TNF)α, and monocyte chemoattractant protein (MCP)-1, are often elevated in individuals after acute pancreatitis but what determines their levels is poorly understood. Gut hormones have emerged as possible modulators of inflammatory response. The aim was to investigate the associations between pro-inflammatory cytokines and a comprehensive panel of gut hormones after an episode of acute pancreatitis...
December 29, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29282478/tumor-necrosis-factor-%C3%AE-stimulates-human-amelotin-gene-transcription-in-gingival-epithelial-cells
#5
Mizuho Yamazaki, Yasunobu Iwai, Keisuke Noda, Sari Matsui, Ayako Kato, Hideki Takai, Yohei Nakayama, Yorimasa Ogata
OBJECTIVE: Amelotin (AMTN) is an enamel protein that is localized in the basal lamina of ameloblasts in their maturation stage and the internal basal lamina of junctional epithelium (JE) and it is suggested that AMTN could be involved in the dentogingival attachment. To elucidate the transcriptional regulation of human AMTN gene in inflamed gingiva, we have analyzed the effect of tumor necrosis factor-α (TNF-α) on the expression of AMTN gene in Ca9-22 and Sa3 human gingival epithelial cells...
December 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29260240/a-cyclic-pathway-of-p2%C3%A2-%C3%A3-%C3%A2-7-bradykinin-and-dopamine-receptor-activation-induces-a-sustained-articular-hyperalgesia-in-the-knee-joint-of-rats
#6
Juliana Maia Teixeira, Carlos Amílcar Parada, Cláudia Herrera Tambeli
OBJECTIVE: We investigated whether: (1) P2 × 7 receptor activation by its agonist (BzATP) induces articular hyperalgesia in the rat's knee joint via inflammatory mechanisms and (2) activation of P2 × 7 receptors by endogenous ATP contributes to the articular hyperalgesia induced by bradykinin, TNF-α, IL-1β, CINC-1, PGE2, and dopamine. METHODS: The articular hyperalgesia was quantified using the rat knee joint incapacitation test. The knee joint inflammation, characterized by the concentration of pro-inflammatory cytokines and by neutrophil migration, was quantified in the synovial lavage fluid by ELISA and myeloperoxidase enzyme activity assay, respectively...
December 19, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29256007/methylation-of-cytokines-gene-promoters-in-il-1%C3%AE-treated-human-intestinal-epithelial-cells
#7
Fabio Caradonna, Ilenia Cruciata, Ilaria Schifano, Chiara La Rosa, Flores Naselli, Roberto Chiarelli, Anna Perrone, Carla Gentile
OBJECTIVE AND DESIGN: Epigenetic regulation is important in the activation of inflammatory cells. In the present study, we evaluated if DNA-methylation variations are involved in Interleukin-1β (IL-1β)-induced intestinal epithelial cells activation. MATERIALS AND METHODS: Differentiated Caco-2 cells were exposed to IL-1β or to 5-azadeoxycytidine (5-azadC) for 24 or 48 h. Genome-wide methylation status was evaluated, while DNA methylation status at the promoter region of the gene encoding interleukin-6, 8 and 10 (IL-6, 8 and 10) was estimated...
December 18, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29230506/the-isoprenoid-end-product-n6-isopentenyladenosine-reduces-inflammatory-response-through-the-inhibition-of-the-nf%C3%AE%C2%BAb-and-stat3-pathways-in-cystic-fibrosis-cells
#8
Antonietta Santoro, Elena Ciaglia, Vanessa Nicolin, Alessandra Pescatore, Lucia Prota, Mario Capunzo, Matilde V Ursini, Stefania L Nori, Maurizio Bifulco
OBJECTIVE: N6-isopentenyladenosine (iPA) is an intermediate of the mevalonate pathway that exhibits various anti-cancer effects. However, studies on its anti-inflammatory activity are scarce and underlying molecular mechanisms are unknown. Therefore, we aimed to investigate the ability of iPA to exert anti-inflammatory effects in the human cystic fibrosis (CF) cell model of exacerbated inflammation. MATERIALS AND METHODS: TNFα-stimulated CF cells CuFi-1 and its normal counterpart NuLi-1 were pre-treated with increasing concentrations of iPA and cell viability and proliferation were assessed by MTT and BrdU assays...
December 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29230505/polymorphisms-and-expression-of-inflammasome-genes-are-associated-with-the-development-and-severity-of-rheumatoid-arthritis-in-brazilian-patients
#9
Catarina Addobbati, Heidi Lacerda Alves da Cruz, José Eduardo Adelino, Amanda Luíze Melo Tavares Ramos, Thiago Sotero Fragoso, Alexandre Domingues, Ângela Luiza Branco Pinto Duarte, Renê Donizeti Ribeiro Oliveira, Paulo Louzada-Júnior, Eduardo Antônio Donadi, Alessandra Pontillo, Jaqueline de Azevêdo Silva, Sergio Crovella, Paula Sandrin-Garcia
OBJECTIVE: In the present study, we analyzed the possible association of inflammasome gene variants and expression to rheumatoid arthritis (RA)'s development and severity in the Brazilian population. MATERIALS AND METHODS: Thirteen single nucleotide polymorphisms within six inflammasome genes (NLRP1, NLRP3, NLRC4, AIM2, CARD8, CASP1) as well as IL1B and IL18 genes in two different Brazilian populations (from Northeast and Southeast Brazil) were analyzed. We also evaluated inflammasome gene expression profile in resting and LPS + ATP-treated monocytes from RA patients and healthy individuals...
December 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29196771/the-interrelation-of-osteoarthritis-and-diabetes-mellitus-considering-the-potential-role-of-interleukin-10-and-in-vitro-models-for-further-analysis
#10
REVIEW
Silke Schwarz, Ingo Mrosewski, Sandeep Silawal, Gundula Schulze-Tanzil
INTRODUCTION: Today, not only the existence of an interrelation between obesity/adipositas and osteoarthritis (OA) but also the association of OA and diabetes mellitus (DM) are widely recognized. Nevertheless, shared influence factors facilitating OA development in DM patients still remain speculative up until now. To supplement the analysis of clinical data, appropriate in vitro models could help to identify shared pathogenetic pathways. Informative in vitro studies could later be complemented by in vivo data obtained from suitable animal models...
December 1, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29181545/non-celiac-gluten-sensitivity-people-without-celiac-disease-avoiding-gluten-is-it-due-to-histamine-intolerance
#11
REVIEW
Wolfgang J Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Harald Mangge, Sandra J Holasek
INTRODUCTION: Food intolerance/malabsorption is caused by food ingredients, carbohydrates (mainly lactose and fructose), proteins (gluten), and biogenic amines (histamine) which cause nonspecific gastrointestinal and extra-intestinal symptoms. Here we focus on possible etiologic factors of intolerance/malabsorption especially in people with non-celiac gluten sensitivity (NCGS) or the so-called people without celiac disease avoiding gluten (PWCDAG) and histamine intolerance. METHODS: Recognizing the recently described symptoms of NCGS (PWCDAG) we review correlations and parallels to histamine intolerance (HIT)...
November 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29181544/angiotensin-1-7-but-not-the-thrombin-cleaved-osteopontin-c-terminal-fragment-attenuates-osteopontin-mediated-macrophage-induced-endothelial-cell-inflammation
#12
Rachel Hamias, Assaf Rudich, George Greenberg, Gabriel Szendro, Talya Wolak
OBJECTIVE AND DESIGN: Evaluating the pro-/anti-inflammatory activity of the C-terminal cleavage product of osteopontin in comparison to angiotensin 1-7. MATERIAL AND SUBJECTS: Human coronary endothelial cells (hcEC) treated with conditioned media from human U937 macrophages. TREATMENT: Macrophages were (pre)treated with C-terminal, full-length or N-terminal osteopontin (OPN-C, OPN-FL, OPN-N, respectively), angiotensin II, angiotensin 1-7 or TNF-α...
November 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29177921/inhibitory-effects-and-related-molecular-mechanisms-of-total-flavonoids-in-mosla-chinensis-maxim-against-h1n1-influenza-virus
#13
Xiao-Xia Zhang, Qiao-Feng Wu, Yun-Liang Yan, Feng-Ling Zhang
OBJECTIVE: The Shixiangru (Mosla chinensis Maxim) total flavonoids (STF) mainly contain luteolin and apigenin. The study aims to examine the inhibitory effects of STF on anti-H1N1 influenza virus and its related molecular mechanisms in pneumonia mice. METHODS: The viral pneumonia mice were treated with Ribavirin or various doses of STF. We observed histological changes of lung by immunohistochemistry and measured lung index to value anti-influenza virus effects of STF...
November 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29164268/mapping-of-the-binding-sites-of-human-diamine-oxidase-dao-monoclonal-antibodies
#14
Hubert G Schwelberger, Johannes Feurle, Gunnar Houen
OBJECTIVE: Recently we characterized five mouse monoclonal antibodies that allow the specific and sensitive detection of human diamine oxidase (DAO). To understand differences in binding characteristics and recognition of enzyme variants, we mapped the antibody binding sites. METHODS: Fragments of human DAO were expressed as glutathione-S-transferase fusion proteins that were used for testing antibody binding on immunoblots. Combined information from species cross-reactivity, sequence comparison and binding site-prediction software were used to localize the epitope recognized by each antibody...
November 21, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29164267/intracellular-apoptotic-pathways-a-potential-target-for-reducing-joint-damage-in-rheumatoid-arthritis
#15
REVIEW
Bonnie Williams, Anak Dharmapatni, Tania Crotti
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that results in both local and systemic bone erosion, causing significant joint deformities and functional disability. The increased number of synovial fibroblasts, inflammatory cells and osteoclasts in RA is associated with reduced apoptosis in these cells. The ability to modulate the cell proliferation or death (particularly apoptosis) is recognised for its immense therapeutic potential. Identifying new therapeutics to assist in stimulating apoptosis within the synovial joints therefore may be beneficial in reducing inflammation and bone loss in RA patients...
November 21, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29151155/intraurethral-injection-with-lps-an-effective-experimental-model-of-prostatic-inflammation
#16
Fabiana Oliveira Dos Santos Gomes, Amanda Costa Oliveira, Edlene Lima Ribeiro, Bruna Santos da Silva, Laise Aline Martins Dos Santos, Ingrid Tavares de Lima, Amanda Karolina Soares E Silva, Shyrlene Meiry da Rocha Araújo, Terezinha Gonçalves, Mario Ribeiro de Melo-Junior, Christina Alves Peixoto
OBJECTIVE: Chronic inflammation has been recognized as having a prominent role pathogenesis of benign prostatic hyperplasia (BPH) and cancer. It is believed that chronic inflammation induces prostatic fibromuscular growth. This correlation has been clearly illustrated by both in vivo and in vitro studies; however, current experimental models of BPH require complex surgery or hormonal treatment. Therefore, the aim of the present study was to propose a new murine model of BPH/prostatitis induced by intraurethral injection of LPS...
November 18, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29134230/baicalin-in-flavocoxid-may-act-against-hepatitis-b-virus-via-a-pro-inflammatory-pathway
#17
LETTER
Salvatore Chirumbolo
No abstract text is available yet for this article.
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29134229/decursin-and-decursinol-angelate-molecular-mechanism-and-therapeutic-potential-in-inflammatory-diseases
#18
REVIEW
Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Lee
Epidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots of Angelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase C...
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29134228/author-correction-novel-six-week-protocol-for-generating-functional-human-connective-tissue-type-mctc-mast-cells-from-buffy-coats
#19
Issan Yee San Tam, Chun Wai Ng, See-Ying Tam, Hang Yung Alaster Lau
The online version of the original article can.
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29127444/altered-mtorc1-signalling-may-contribute-to-macrophage-dysregulation-in-hidradenitis-suppurativa
#20
LETTER
Valerio De Vita
No abstract text is available yet for this article.
November 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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