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Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]

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https://www.readbyqxmd.com/read/28803264/hyaluronan-in-the-experimental-injury-of-the-cartilage-biochemical-action-and-protective-effects
#1
REVIEW
Angela Avenoso, Angela D'Ascola, Michele Scuruchi, Giuseppe Mandraffino, Alberto Calatroni, Antonino Saitta, Salvatore Campo, Giuseppe M Campo
INTRODUCTION: Our knowledge of extracellular matrix (ECM) structure and function has increased enormously over the last decade or so. There is evidence demonstrating that ECM provides signals affecting cell adhesion, shape, migration, proliferation, survival, and differentiation. ECM presents many domains that become active after proteolytic cleavage. These active ECM fragments are called matrikines which play different roles; in particular, they may act as potent inflammatory mediators during cartilage injury...
August 12, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28791419/mapping-of-the-binding-sites-of-human-histamine-n-methyltransferase-hnmt-monoclonal-antibodies
#2
Hubert G Schwelberger, Johannes Feurle, Gunnar Houen
OBJECTIVE: Recently, we characterized mouse monoclonal antibodies that allow the specific and sensitive detection of human histamine N-methyltransferase (HNMT). To understand differences in binding characteristics and recognition of enzyme variants we mapped the antibody binding sites. METHODS: Fragments of human HNMT were expressed as glutathione S-transferase fusion proteins that were used for testing antibody binding on immunoblots. Combined information from species cross-reactivity, sequence comparison, protein structure, and binding site prediction software were used to localize the epitope recognized by each antibody...
August 8, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28780681/interaction-of-wip1-and-nf-%C3%AE%C2%BAb-regulates-neuroinflammatory-response-in-astrocytes
#3
Fan Xu, Lifei Chen, Xin Zhao, Haibin Zhong, Ling Cui, Li Jiang, Hui Huang, Li Li, Siming Zeng, Min Li
OBJECTIVE: The aims of the present study were to detect the interaction of Wip1 and NF-κB P65 in retina of an LPS-induced astrocytes activation model. METHODS: The interaction between Wip1 and nuclear factor kappa B (NF-κB) P65 was observed in lipopolysaccharide (LPS)-stimulated primary rat astrocytes derived from retina. The expressions of Wip1 and NF-κB P65 were evaluated using Western blot and RT-PCR. Small interfering RNA (siRNA) against Wip1 was transfected into astrocytes to clarify the phosphorylation status and nuclear translocation of NF-κB P65 and expressions of these proinflammatory factors...
August 5, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28752178/inhibitory-effect-of-jak-inhibitor-on-mechanical-stress-induced-protease-expression-by-human-articular-chondrocytes
#4
Takahiro Machida, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Masahiro Horita, Ayumu Takeshita, Daisuke Kaneda, Aki Yoshida, Toshifumi Ozaki
OBJECTIVE: To investigate whether janus kinase (JAK) inhibitor exhibits a chondro-protective effect against mechanical stress-induced expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMPs) in human chondrocytes. MATERIALS AND METHODS: Normal human articular chondrocytes were seeded onto stretch chambers and incubated with or without tofacitinib (1000 nM) for 12 h before mechanical stimulation or cytokine stimulation...
July 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28741130/epigenetic-involvement-in-etiopathogenesis-and-implications-in-treatment-of-systemic-lupus-erythematous
#5
REVIEW
Arron Munggela Foma, Saeed Aslani, Jafar Karami, Ahmadreza Jamshidi, Mahdi Mahmoudi
BACKGROUND: Recent researches in the field of genetics have extended our knowledge through the discovery of genetic factors associated with autoimmune diseases (AID). Genetics by itself, however, cannot elucidate all the uncertainties encountered in the etiopathology of AID. On the other hand, incomplete harmony in the prevalence of AID in identical twins suggests that non-genetic factors may play an important role in determining the disease susceptibility. Besides, epigenetics, which is defined by changes in gene expression without a corresponding change in the DNA sequences, has come in to provide new awareness in the disease etiopathology by bridging the genetic and epigenetic factors...
July 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28711989/striking-the-right-immunological-balance-prevents-progression-of-tuberculosis
#6
REVIEW
Shachi Pranjal Vyas, Ritobrata Goswami
INTRODUCTION: Tuberculosis (TB) caused by infection with Mycobacterium tuberculosis (Mtb) is a major burden for human health worldwide. Current standard treatments for TB require prolonged administration of antimycobacterial drugs leading to exaggerated inflammation and tissue damage. This can result in the reactivation of latent TB culminating in TB progression. Thus, there is an unmet need to develop therapies that would shorten the duration of anti-TB treatment and to induce optimal protective immune responses to control the spread of mycobacterial infection with minimal lung pathology...
July 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28685196/effects-of-sevoflurane-on-nf-%C3%B0%C2%BAb-and-tnf-%C3%AE-expression-in-renal-ischemia-reperfusion-diabetic-rats
#7
Yu Zhang, Fang Hu, Jianghua Wen, Xiaohong Wei, Yingjuan Zeng, Ying Sun, Shunkui Luo, Liao Sun
BACKGROUND: Ischemia-reperfusion (I/R) injury is the main reason of acute renal failure. However, inflammatory response and cell apoptosis are important mechanisms implicated in I/R injury. Recent studies indicated that nuclear factor kappa B (NF-кB) and tumor necrosis factor α (TNF-α) are both involved in these mechanisms. Sevoflurane reduces NF-кB and TNF-α expression in rats' heart and decreases their renal I/R injury. However, few studies are available regarding the effect of sevoflurane on kidney of diabetic rats...
July 6, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28681194/tlr4-regulates-insulin-resistant-proteins-to-increase-apoptosis-in-the-mouse-retina
#8
Li Liu, Youde Jiang, Elizabeth Curtiss, Ken-Ichiro Fukuchi, Jena J Steinle
OBJECTIVE AND DESIGN: Work in multiple organs has suggested that toll-like receptor 4 (TLR4) may play a role in insulin resistance. Additional studies have shown a negative role for TLR4 on retinal health. We have previously reported that β-adrenergic receptors can regulate both TLR4 signal transduction, as well as insulin signaling in the retina and in retinal endothelial cells. Thus, we hypothesized that TLR4 would regulate retinal insulin signaling. MATERIALS AND METHODS: We used endothelial cell-specific TLR4 knockout mice, as well as TLR4-overexpressing mice for these studies...
July 5, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28676918/evaluation-of-the-in-vitro-and-in-vivo-proinflammatory-activities-of-gold-and-gold-nanoparticles
#9
Isabelle Durocher, Claudie Noël, Valérie Lavastre, Denis Girard
OBJECTIVE AND DESIGN: The aim of this study was to determine potential effects of gold (+) and gold (-) nanoparticles, AuNP(+) and AuNP(-), on neutrophil biology. MATERIAL OR SUBJECTS: Freshly isolated human neutrophils were used for the in vitro aspects and CD-1 mice were used in the in vivo murine air pouch model of acute neutrophilic inflammation. TREATMENT: Human neutrophils were treated with the indicated concentrations of AuNP(+) or AuNP(-) in vitro and mice received 100 or 500 µg/ml AuNP(+) or AuNP(-) into air pouches...
July 4, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28676917/biochemical-and-clinical-relevance-of-alpha-lipoic-acid-antioxidant-and-anti-inflammatory-activity-molecular-pathways-and-therapeutic-potential
#10
REVIEW
Daniele Tibullo, Giovanni Li Volti, Cesarina Giallongo, Sonia Grasso, Daniele Tomassoni, Carmelina Daniela Anfuso, Gabriella Lupo, Francesco Amenta, Roberto Avola, Vincenzo Bramanti
BACKGROUND: The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is the antioxidant activity due to its ability to scavenge and inactivate free radicals. Furthermore, LA has been shown to chelate toxic metals both directly and indirectly by its capability to enhance intracellular glutathione (GSH) levels. This last property is due to its ability to interact with GSH and recycle endogenous GSH...
July 4, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28669029/slc11a1-nramp-1-gene-modulates-immune-inflammation-genes-in-macrophages-during-pristane-induced-arthritis-in-mice
#11
Mara A Correa, Tatiane Canhamero, Andrea Borrego, Iana S S Katz, José R Jensen, José Luiz Guerra, Wafa H K Cabrera, Nancy Starobinas, Jussara G Fernandes, Orlando G Ribeiro, Olga M Ibañez, Marcelo De Franco
OBJECTIVE AND DESIGN: Pristane-induced arthritis (PIA) in AIRmax mice homozygous for Slc11a1 R and S alleles was used to characterize the influence of Slc11a1 gene polymorphism on immune responses during disease manifestation. Previous reports demonstrated that the presence of the Slc11a1 S allele increased the incidence and severity of PIA in AIRmax (SS) , suggesting that this gene could interact with inflammatory loci to modulate PIA. We investigated the effects of Slc11a1 alleles on the activation of phagocytes during PIA...
July 1, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28660310/advanced-glycation-endproducts-induce-self-and-cross-tolerance-in-monocytes
#12
Florian Uhle, Sebastian Weiterer, Benedikt Hermann Siegler, Thorsten Brenner, Christoph Lichtenstern, Markus Alexander Weigand
INTRODUCTION: Advanced glycation endproducts (AGEs) are well-known inflammatory mediators, which are recognized by immune cells through their corresponding receptor RAGE and have been shown to participate in the pathophysiology of a variety of acute as well as chronic inflammatory diseases. Nevertheless, no data are available on the aftermath of AGE recognition on immune cells. MATERIALS AND METHODS: We used the monocytic cell line MonoMac6 as well as primary human monocytes for double stimulation experiments...
June 28, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28656364/the-critical-role-of-macrophages-in-the-pathogenesis-of-hidradenitis-suppurativa
#13
REVIEW
Ahmed Shah, Raed Alhusayen, Saeid Amini-Nik
INTRODUCTION: Hidradenitis suppurativa (HS) is a painful chronic inflammatory disease with a prevalence between 1 and 4% of general population. The pathogenesis of HS long eluded scientists, but growing evidence suggests that it is a consequence of inflammatory dysregulation. FINDINGS: Recent studies suggest that dysregulated immune response to skin flora and overexpression of inflammatory cytokines leads to chronic skin inflammation seen in HS. Macrophages are the most numerous inflammatory cells found in HS infiltrates and release numerous pro-inflammatory cytokines such as IL-23, and IL-1β and TNF-α, exacerbating the inflammation and contributing to the pathogenesis of HS...
June 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28653218/2k1c-activated-angiotensin-ii-ang-ii-exacerbates-vascular-damage-in-a-rat-model-of-arthritis-through-the-atr-erk1-2-signaling-pathway
#14
Ying Zhang, Xuexia Luo, Yue Zhou, Huaxun Wu, Jingyu Chen, Ying Wang, Danian Chen, Zhouwei Xu, Shangxue Yan, Wei Wei
OBJECTIVE: To explore the role and mechanism of the two-kidney one-clip (2K1C)-activated Angiotensin II (Ang II) in the development of vascular damage in adjuvant-induced arthritis (AA) rats. METHODS: 2K1C rats were established in normal and AA rats for 35 days. Hypertension, endothelial dysfunction, and vascular hypertrophy induced by 2K1C-activated Ang II in systemic inflammation rats were evaluated. The levels of Ang II and TNF-α in serum were observed by ELISA kits...
June 26, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28647836/from-medicinal-plant-extracts-to-defined-chemical-compounds-targeting-the-histamine-h4-receptor-curcuma-longa-in-the-treatment-of-inflammation
#15
Annika Frank, Saleh Abu-Lafi, Azmi Adawi, Johannes S Schwed, Holger Stark, Anwar Rayan
OBJECTIVES: The aim was to evaluate the activity of seven medicinal, anti-inflammatory plants at the hH4R with focus on defined chemical compounds from Curcuma longa. MATERIALS: Activities were analyzed with membrane preparations from Sf9 cells, transiently expressing the hH4R, Gαi2 and Gβ1γ2 subunits. METHODS: From the methanolic extract of C. longa curcumin (1), demethoxycurcumin (2) and bis(4-hydroxy-cinnamoyl)methane (3) were isolated, purified with HPLC (elution-time 10...
June 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28647835/resveratrol-alleviates-inflammatory-hyperalgesia-by-modulation-of-reactive-oxygen-species-ros-antioxidant-enzymes-and-erk-activation
#16
Ajeet Kumar Singh, Manjula Vinayak
OBJECTIVES: Impact of ROS in development of hyperalgesia has recently motivated scientists to focus on ROS as novel target of anti-hyperalgesic interventions. However, role of ROS in molecular signaling of hyperalgesia is still poorly understood. The present study is aimed to analyze the effect of dietary antioxidant resveratrol on antioxidant defense system, ROS level and TNFR1-ERK signaling pathway during early and late phase of inflammatory hyperalgesia. METHODS AND MATERIALS: Hyperalgesia was assessed by paw withdrawal latency test in complete Freund's adjuvant-induced hyperalgesic rats...
June 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28646289/delta-neutrophil-index-dni-as-a-novel-diagnostic-and-prognostic-marker-of-infection-a-systematic-review-and-meta-analysis
#17
Jae Hyon Park, Hyeong Ju Byeon, Keum Hwa Lee, Jong Wook Lee, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin
OBJECTIVE: Delta neutrophil index (DNI) representing the number of immature granulocytes is an emerging marker used in diagnosis of infections and prediction of mortality in infected patients. The present study evaluated the diagnostic accuracy of DNI as a predictive and prognostic factor in infected patients. METHODS: We performed a PubMed search on January 1st, 2017 and identified studies that evaluated DNI as either a predictive or prognostic factor in infected patients...
June 23, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28638979/endocytosis-is-required-for-exocytosis-and-priming-of-respiratory-burst-activity-in-human-neutrophils
#18
T Michael Creed, Shweta Tandon, Richard A Ward, Kenneth R McLeish
OBJECTIVE AND DESIGN: Neutrophil generation of reactive oxygen species (ROS) is enhanced by exposure to pro-inflammatory agents in a process termed priming. Priming is depending on exocytosis of neutrophil granules and p47(phox) phosphorylation-dependent translocation of cytosolic NADPH oxidase components. Clathrin-mediated endocytosis was recently reported to be necessary for priming, but the mechanism linking endocytosis to priming was not identified. The present study examined the hypothesis that endocytosis regulates neutrophil priming by controlling granule exocytosis...
June 21, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28620798/-inflammatory-skin-march-in-atopic-dermatitis-and-psoriasis
#19
REVIEW
Masutaka Furue, Takafumi Kadono
BACKGROUND: Comorbidities of cardiovascular diseases (CVDs), metabolic syndrome and autoimmune diseases with systemic inflammation are recent topics in medicine. Inflammatory skin diseases such as atopic dermatitis and psoriasis are an active source of diverse proinflammatory cytokines and chemokines, which are readily detectable in the circulation and are likely to be involved in developing comorbidities. EVIDENCE: Both atopic dermatitis and psoriasis are frequently comorbid with CVD, metabolic syndrome and autoimmune diseases, the consequence of which is called "inflammatory skin march", "psoriatic march" or "march of psoriasis"...
June 15, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28616734/di-2-pyridylketone-4-4-dimethyl-3-thiosemicarbazone-dp44mt-an-anticancer-agent-exerts-an-anti-inflammatory-effect-in-activated-human-mast-cells
#20
Sun-Young Nam, Na-Ra Han, Kyoung Wan Yoon, Hyung-Min Kim, Hyun-Ja Jeong
OBJECTIVE: Inflammation has been closely associated with the development and progression of cancer. Previously, we reported that mast cells play a critical role in tumor growth. The purpose of this study is to investigate the anti-inflammatory effect of an anticancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), on an activated human mast cell line, in this case HMC-1 cells. METHODS: We evaluated the effect and specific molecular mechanism of Dp44mT on phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI) using HMC-1 cells...
June 14, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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