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Clinical and Applied Thrombosis/hemostasis

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https://www.readbyqxmd.com/read/28335612/thrombin-generation-in-patients-with-suspected-venous-thromboembolism
#1
Fredrik Wexels, Ola E Dahl, Are H Pripp, Ingebjørg Seljeflot
Increasing number of patients with clinically suspected venous thromboembolism is referred to radiological departments for definitive diagnosis. A simple assay to exclude the diagnosis and avoid radiological examinations is needed. We have reported correlations between D-dimer and prothrombin fragment 1 + 2 measured in plasma and urine. To further develop an analysis based on urine, more understanding of thrombin generation in these patients is needed. The aim of this study was to compare ex vivo thrombin generation with in vivo markers in plasma and urine in patients with and without venous thromboembolism...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27789605/reversal-of-anticoagulation-and-management-of-bleeding-in-patients-on-anticoagulants
#2
Prajwal Dhakal, Supratik Rayamajhi, Vivek Verma, Krishna Gundabolu, Vijaya R Bhatt
Bleeding is the most common complication of all anticoagulants. Any bleeding patient on an anticoagulant should be risk-stratified based on hemodynamic instability, source of bleeding, and degree of blood loss. Although minor bleed may be managed with discontinuation of anticoagulant, major bleed may require transfusion of blood products and use of specific antidote. The residual effects of each anticoagulant may be monitored with distinct coagulation assay. Intravenous or oral vitamin K can reverse the effect of warfarin within 24 to 48 hours and is indicated for any bleeding, international normalized ratio of >10 or 4...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27765812/direct-thrombin-inhibitor-for-lvad-thrombosis-a-closer-look
#3
Jessica Rimsans, Katelyn W Sylvester, Jean M Connors
Available options for the treatment of advanced heart failure have expanded to include the use of mechanical circulatory assist devices to improve quality of life in those both eligible and ineligible for heart transplant. Although there have been significant advancements in device technologies, anticoagulation protocols, and multidisciplinary team management, bleeding and thrombosis are the most common adverse effects. Management strategies for pump thrombosis and their outcomes vary considerably among mechanical circulatory support centers and include intensification of antithrombotic therapy (medical) and device exchange (surgical)...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27481876/endothelin-1-gene-polymorphism-and-its-level-predict-the-risk-of-venous-thromboembolism-in-male-indian-population
#4
Babita Kumari, Amit Prabhakar, Anita Sahu, Tathagata Chatterjee, Tarun Tyagi, Neha Gupta, Velu Nair, Mohammad Zahid Ashraf
OBJECTIVES: Genes related to endothelial function are responsible for the regulation of vascular functions. AIM: The aim of this study is to investigate whether endothelial gene-associated polymorphism and their plasma levels can be used to predict the risk for venous thromboembolism (VTE). METHODS: We studied 133 patients with VTE and 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, EDN 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, vascular endothelial growth factor C936T, and endothelial cell protein C receptor A6936G polymorphism was genotyped by restriction fragment length polymorphism...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27161759/efficacy-and-bleeding-risk-of-antithrombin-supplementation-in-patients-with-septic-disseminated-intravascular-coagulation-a-third-survey
#5
Toshiaki Iba, Satoshi Gando, Daizoh Saitoh, Toshiaki Ikeda, Hideaki Anan, Shigeto Oda, Nobuya Kitamura, Shigeru Mori, Joji Kotani, Yasuhiro Kuroda
INTRODUCTION: Although recent studies have reported the efficacy of antithrombin (AT) supplementation for sepsis-associated disseminated intravascular coagulation (DIC), the factors that influence AT's effect have not been sufficiently studied. The purpose of this survey was to identify factors that modulate the effects and the adverse effects of AT. METHODS: We performed a multi-institutional survey. The data from 159 patients with septic DIC with AT ≤70% and who had undergone AT supplementation were analyzed...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27099386/protection-from-pregnancy-loss-in-women-with-hereditary-thrombophilia-when-associated-with-fibrinogen-polymorphism-thr331ala
#6
Makoto Ikejiri, Hideo Wada, Yuki Kamimoto, Kaname Nakatani, Tomoaki Ikeda
No abstract text is available yet for this article.
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26994297/development-of-a-predictive-nomogram-for-the-change-in-pt-inr-upon-discontinuation-of-bivalirudin-as-a-bridge-to-warfarin
#7
Benjamin Hohlfelder, David DeiCicchi, Katelyn W Sylvester, Jean M Connors
Appropriate timing of bivalirudin discontinuation as a bridge to warfarin is complicated, as bivalirudin may cause a falsely prolonged international normalized ratio (INR). The purpose was to evaluate patient and medication characteristics associated with differences in INR prolongation caused by bivalirudin. Adult patients receiving bivalirudin as a bridge to warfarin in 2014 were retrospectively evaluated. Patients were excluded if they had known thrombophilia or inappropriate INR monitoring after discontinuation of bivalirudin...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26739542/assessment-of-the-quality-of-chronic-anticoagulation-control-with-time-in-therapeutic-range-in-atrial-fibrillation-patients-treated-with-vitamin-k-antagonists-by-hemostasis-specialists-the-terra-registry-tiempo-en-rango-en-la-rep%C3%A3%C2%BAblica-argentina
#8
Carlos Tajer, José Ceresetto, Federico Jorge Bottaro, Alejandra Martí, Marcelo Casey
BACKGROUND: Oral anticoagulation therapy with vitamin K antagonists (VKA) such as warfarin and acenocoumarol is recommended in patients with atrial fibrillation (AF) and risk factors for embolism. The quality of anticoagulation control with VKA may be assessed by the time in therapeutic range (TTR). In our country, there are no data available about the quality of anticoagulation in patients with AF. The primary goal of our study was to assess the level of effective anticoagulation in a multicenter network of anticoagulation clinics in Argentina, which included patients with nonvalvular AF (NVAF) treated with VKA oral anticoagulants...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26699867/patient-characteristics-and-antithrombotic-prescribing-patterns-in-patients-with-atrial-fibrillation-in-tasmania
#9
Durga Bista, Leanne Chalmers, Gregory M Peterson, Luke R E Bereznicki
Limited data are available on atrial fibrillation (AF) and its clinical management and outcomes from an Australian perspective. This study was designed to examine the patient characteristics and antithrombotic treatment patterns among patients with AF in Tasmania, Australia. This retrospective observational study reviewed and followed patients with AF admitted to Tasmania's 3 major hospitals between January 2011 and June 2012. Patients were excluded if they had only 1 episode of AF that reverted spontaneously or upon cardioversion without any documented recurrences...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26659696/renal-abnormalities-among-egyptian-children-with-hemophilia-a-using-renal-scintigraphy-relation-to-risk-factors-and-disease-severity
#10
Ahmed Alsaeed Hamed, Mennatallah Hatem Shalaby, Nihal Saad El-Kinawy, Alaa Adel Elamawy, Shereen Mohamed Abd El-Ghany
Many risk factors may contribute to renal disease in patients with hemophilia A. AIM: We aimed to evaluate functional and structural renal abnormalities among a group of Egyptian children with severe and moderate hemophilia A using technetium-99m diethylene triamine pentaacetic acid ((99m)Tc-DTPA) and technetium-99 m dimercaptusuccinic acid ((99m)Tc-DMSA) scan. We also aimed to determine the relation between these abnormalities and different risk factors and disease severity. PATIENTS AND METHODS: Forty male patients, 16 with severe and 24 with moderate hemophilia A, were enrolled in this study...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26620416/decreased-frequency-of-il-17f-rs763780-site-allele-g-is-associated-with-genetic-susceptibility-to-immune-thrombocytopenia-in-a-chinese-population
#11
Huiyuan Li, Zeping Zhou, Wenlin Tai, Weiyang Feng, Donglei Zhang, Xueping Gu, Renchi Yang
Interleukin 17F (IL-17F) is an inflammatory cytokine that plays an important role in autoimmune disease by inducing the expression of multiple chemokines, cytokines, and adhesion molecules. In vitro functional analysis revealed that IL-17F rs763780 polymorphism is associated with IL-17 expression and activity. Thus, considering the abnormal percentage of T helper 17 cells in patients with primary immune thrombocytopenia (ITP), we speculated there was a possible association between the IL-17F rs763780 polymorphisms and genetic susceptibility to ITP in a Chinese Han population...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26607436/the-relationship-between-serum-endocan-levels-with-the-presence-of-slow-coronary-flow-a-cross-sectional-study
#12
Harun Kundi, Murat Gok, Emrullah Kiziltunc, Canan Topcuoglu, Mustafa Cetin, Hulya Cicekcioglu, Burcu Ugurlu, Feridun Vasfi Ulusoy
BACKGROUND: The aim of this study was to investigate the relationship between endocan levels with the presence of slow coronary flow (SCF). METHODS: In this cross-sectional study, a total of 88 patients, who admitted to our hospital, were included in this study. Of these, 53 patients with SCF and 35 patients with normal coronary flow were included in the final analysis. Coronary flow rates of all patients were determined by the Timi Frame Count (TFC) method. RESULTS: In correlation analysis, endocan levels revealed a significantly positive correlation with high sensitive C-reactive protein and corrected TFC...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26574574/evaluation-of-the-diagnostic-performance-of-fibrin-monomer-in-comparison-to-d-dimer-in-patients-with-overt-and-nonovert-disseminated-intravascular-coagulation
#13
Neha Singh, Hara Prasad Pati, Seema Tyagi, Ashish Datt Upadhyay, Renu Saxena
INTRODUCTION: Disseminated intravascular coagulation (DIC) is a thrombohemorrhagic disorder characterized by hyperactivation of coagulation and secondary fibrinolysis. AIM: The primary aim of this prospective study was to evaluate and compare the diagnostic performance of fibrin monomer (FM) and d-dimer (DD) for the preemptive diagnosis of DIC in the early stages. MATERIALS AND METHODS: The patients were categorized into 3 groups: overt DIC, nonovert DIC, and non-DIC based on the International Society of Thrombosis and Hemostasis scoring for overt DIC and the modified nonovert-DIC criteria...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26566667/heart-failure-and-mortality-in-patients-with-nonvalvular-atrial-fibrillation-started-on-novel-oral-anticoagulant-therapy-a-single-center-experience
#14
Murat Sunbul, Mustafa Oguz, Zekeriya Dogan, Halil Atas, Mehmet Bozbay, Altug Cincin, Mehmet Agirbasli
Heart failure (HF) is the leading cause of in-hospital morbidity and mortality in the elderly population. Coexistence of HF and atrial fibrillation (AF) increases the risk of thromboembolic events. Oral anticoagulant therapy reduces the risk of thromboembolic events in patients with AF. Novel oral anticoagulants (NOACs) have been introduced as an alternative drug for prevention from thromboembolic events in patients with nonvalvular AF. The primary aim of this study is to investigate the clinical effects of warfarin, dabigatran, and rivaroxaban in patients with nonvalvular AF...
July 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28049360/identification-of-genetic-aberrations-in-thrombomodulin-gene-in-patients-with-recurrent-venous-thromboembolism
#15
Abrar Ahmad, Kristina Sundquist, Bengt Zöller, Peter J Svensson, Jan Sundquist, Ashfaque A Memon
Thrombomodulin (THBD) serves as a cofactor for thrombin-mediated activation of anticoagulant protein C pathway. Genetic aberrations in THBD have been studied in arterial and venous thrombosis. However, genetic changes in THBD and their role in the risk assessment of recurrent venous thromboembolism (VTE) are not well understood. The aim of the present study was to identify the genetic aberrations in THBD and their association with the risk of VTE recurrence in a prospective population-based study. We sequenced the entire THBD gene, first in selected patients with VTE (n = 95) by Sanger sequencing and later validated those polymorphisms with minor allele frequency (MAF) ≥5% in the whole study population (n = 1465 with the follow-up period of 1998-2008) by Taqman polymerase chain reaction...
May 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27461564/antiplatelet-and-anticoagulant-therapies-for-prevention-of-ischemic-stroke
#16
REVIEW
Nikhil Kapil, Yvonne H Datta, Naila Alakbarova, Eric Bershad, Magdy Selim, David S Liebeskind, Ornina Bachour, Gundu H R Rao, Afshin A Divani
Ischemic stroke represents one of the leading causes of death and disability in both the United States and abroad, particularly for patients with prior ischemic stroke or transient ischemic attack (TIA). A quintessential aspect of secondary stroke prevention is the use of different pharmacological agents, mainly antiplatelets and anticoagulants. Antiplatelets and anticoagulants exhibit their effect by blocking the activation pathways of platelets and the coagulation cascade, respectively. Clinical trials have demonstrated the safety and efficacy of antiplatelets for noncardioembolic stroke prevention, while anticoagulants are more often used for cardioembolic stroke prevention...
May 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27418637/the-importance-of-magnesium-values-in-patients-with-stemi-admitted-to-the-emergency-department
#17
Melih Yuksel, Turgay Isik, Ibrahim Halil Tanboga, Erkan Ayhan, Mehmet Emre Erimsah, Selim Topcu, Selami Demirelli, Enbiya Aksakal, Serdar Sevimli
AIM: The aim of this study is to examine the relationship between initial magnesium (Mg) levels, electrocardiographic no-reflow, and long-term mortality in patients who underwent primary percutaneous coronary intervention (pPCI) due to ST-segment elevation myocardial infarction (STEMI). METHODS: A total of 111 patients with pPCI participated in the study. Magnesium and high-sensitive C-reactive protein (hs-CRP) were measured. The sum of ST-segment elevation was measured immediately before and 60 minutes after the restoration of coronary flow...
May 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27056935/antiphospholipid-antibodies-and-renal-impairment-parameters-in-diabetic-nephropathy-preliminary-data
#18
Mirjana Bećarević, Velibor Čabarkapa, Mirjana Đerić, Svetlana Ignjatović
OBJECTIVE: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. METHODS: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay...
May 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26984935/effects-of-lep-g2548a-and-lepr-q223r-polymorphisms-on-serum-lipids-and-response-to-simvastatin-treatment-in-chinese-patients-with-primary-hyperlipidemia
#19
Kang Li, Yanhong Liu, Scott A Venners, Yi-Hsiang Hsu, Shanqun Jiang, Justin Weinstock, Yiyang Sun, Binyan Wang, Xiping Xu
OBJECTIVES: To investigate whether LEP G2548A and LEPR Q223R polymorphisms influence serum lipid levels and whether the 2 polymorphisms affect the efficacy of simvastatin treatment in Chinese patients with primary hyperlipidemia. METHODS: We used an extreme sampling approach by selecting 212 individuals from the top and bottom 15% of adjusted lipid-lowering response residuals to simvastatin (n = 106 in each group of good or bad response) from a total of 734 samples with primary hyperlipidemia...
May 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26873107/assessing-circulating-factor-viia-antithrombin-complexes-in-acute-ischemic-stroke-a-pilot-study
#20
Artur Słomka, Milena Świtońska, Władysław Sinkiewicz, Ewa Żekanowska
AIM: The goal of this study was to determine the levels of factor VII (FVII), factor VIIa-antithrombin complexes (FVIIa-AT), total tissue factor (TF), and tissue factor-bearing microparticles (MPs-TF) in patients with acute ischemic stroke. Further, we sought evidence of an association between hemostatic markers, time of blood sampling, type of treatment, and patient outcomes. METHODS: Venous blood samples were collected from 33 patients on the first day and on the seventh day after stroke diagnosis...
May 2017: Clinical and Applied Thrombosis/hemostasis
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