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Clinical and Applied Thrombosis/hemostasis

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https://www.readbyqxmd.com/read/29558818/biomarkers-of-inflammation-thrombogenesis-and-collagen-turnover-in-patients-with-atrial-fibrillation
#1
Sallu Jabati, Jawed Fareed, Jeffrey Liles, Abigail Otto, Debra Hoppensteadt, Jack Bontekoe, Trung Phan, Amanda Walborn, Mushabbar Syed
The purpose of this study was to determine whether there are any differences in the levels of inflammatory, thrombotic, and collagen turnover biomarkers between individuals with atrial fibrillation (AF) and healthy volunteers. Circulating plasma levels of plasminogen activator inhibitor 1 (PAI-1), CD40-ligand (CD40-L), nucleosomes (which are indicators of cell death), C-reactive protein (CRP), procollagen III N-terminal propeptide (PIIINP), procollagen III C-terminal propeptide (PIIICP), procollagen I N-terminal propeptide, tissue plasminogen activator, and von Willebrand factor were analyzed as potential biomarkers of AF...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29534609/the-renal-elimination-pathways-of-the-dabigatran-reversal-agent-idarucizumab-and-its-impact-on-dabigatran-elimination
#2
Stephan Glund, Guanfa Gan, Viktoria Moschetti, Paul Reilly, Markus Honickel, Oliver Grottke, Joanne Van Ryn
Idarucizumab, a humanized monoclonal antibody fragment (Fab), provides rapid and sustained reversal of dabigatran-mediated anticoagulation. Idarucizumab and dabigatran are mainly eliminated via the kidneys. This analysis aimed to characterize the renal elimination of idarucizumab and investigate the influence of idarucizumab on the pharmacokinetics (PK) of dabigatran and vice versa. Studies were conducted in 5/6 nephrectomized rats, in human volunteers with and without renal impairment, and in a porcine liver trauma model...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29471674/concomitant-versus-individual-administration-of-antithrombin-and-thrombomodulin-for-sepsis-induced-disseminated-intravascular-coagulation-a-nationwide-japanese-registry-study
#3
Yutaka Umemura, Kazuma Yamakawa, Mineji Hayakawa, Daisuke Kudo, Satoshi Fujimi
BACKGROUND: Antithrombin and recombinant human thrombomodulin (rhTM) are individually reported to improve survival in sepsis-induced disseminated intravascular coagulation (DIC). However, continuing controversy exists as to which agent is superior and whether concomitant therapy is superior to individual administration. METHODS: This post hoc analysis included adult patients with sepsis-induced DIC from a nationwide multicenter registry database in Japan. We categorized patients into 4 groups: patients who received (1) individual administration of antithrombin, (2) individual administration of rhTM, (3) both, and (4) neither...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29439639/thrombin-generation-biomarkers-decline-with-parenteral-anticoagulation-an-overlooked-means-of-anticoagulation-monitoring
#4
Craig P McFarland, Stuart E Lind
Anticoagulation therapy is administered to patients to prevent or stop thrombin generation in vivo. Although plasma tests of in vivo thrombin generation have been available for more than 2 decades, they are not routinely used in clinical trials or practice to monitor anticoagulation therapy. We observed a fall in one such marker, the D-dimer antigen, in patients receiving anticoagulation therapy. We therefore conducted a systematic review of the medical literature to document the change in serum biomarkers of thrombin generation following the initiation of anticoagulation therapy...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29374968/fibrinolytic-deficit-and-platelet-activation-in-atrial-fibrillation-and-their-postablation-modulation
#5
Abigail Otto, Jawed Fareed, Jeffrey Liles, Stephen Statz, Amanda Walborn, Timothy Rowe, Sallu Jabati, Debra Hoppensteadt, Mushabar A Syed
This study aims to examine the effects of atrial fibrillation (AF) on the expression of the cellular mediators plasminogen activator inhibitor 1 (PAI-1) and CD40 ligand (CD40-L). Additionally, the effect of catheter ablation on the levels of the aforementioned biomarkers was also examined. In this prospective study, plasma samples were collected from patients with AF at baseline prior to ablation and at 1 and 3 months postablation. There was a statistically significant increase in CD40-L at baseline in patients with AF compared to control ( P = ...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29212375/evaluation-of-monocyte-to-high-density-lipoprotein-cholesterol-ratio-in-the-presence-and-severity-of-metabolic-syndrome
#6
Ali Ugur Uslu, Yahya Sekin, Gulten Tarhan, Nuray Canakcı, Mehmet Gunduz, Mustafa Karagulle
Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a systemic inflammatory marker, and recently, it has been used quite commonly for the assessment of inflammation in cardiovascular disorders. The aim of the present study is to investigate the relevance of MHR as a marker to assess metabolic syndrome (MetS) and MetS severity in clinical practice. A total of 147 patients with MetS who were diagnosed according to National Cholesterol Education Program Adult Treatment Panel III criteria and 134 healthy controls, matched for age and gender, were included in our retrospective study...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29121808/the-prognostic-value-of-lipoprotein-associated-phospholipase-a-2-in-the-long-term-care-of-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#7
Lijiao Yang, Hong Wang, Yida Zhang, Tingting Han, Wenfeng Wang
Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is an independent risk factor for cardiovascular disease. Accordingly, studies from many countries around the world have shown an association between Lp-PLA2 and cardiovascular events in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), but this association has not been documented among the Chinese. The aim of this study was to assess the use of Lp-PLA2 as a useful marker for predicting the long-term prognosis of Chinese patients with ACS undergoing PCI...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29088922/the-role-of-tinzaparin-in-oncology
#8
Evangelos P Dimakakos, Ioannis Vathiotis, Konstantinos Syrigos
Current guidelines recommend low-molecular-weight heparin treatment in patients with cancer with established venous thromboembolism (VTE). The aim of this article was to study the pharmacological properties and effectiveness of tinzaparin in patients with cancer as well as its potential anticancer properties. A search of PubMed and ScienceDirect databases up to March 2016 was carried out to identify published studies that detect the properties and use of tinzaparin in oncology. Protamine sulfate partially (60% to 65%) neutralized tinzaparin's anti-Xa activity...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29088921/platelet-to-lymphocyte-ratio-and-neutrophil-to-lymphocyte-ratio-as-risk-factors-for-venous-thrombosis
#9
Andrea Artoni, Maria Abbattista, Paolo Bucciarelli, Francesca Gianniello, Erica Scalambrino, Emanuela Pappalardo, Flora Peyvandi, Ida Martinelli
High platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) are associated with an increased risk of arterial thrombosis, but their role in venous thromboembolism (VTE) has not been fully investigated. A case-control study, of 486 patients with VTE, 100 with cerebral vein thrombosis (CVT), and 299 healthy individuals, was carried out to investigate whether high PLR or NLR values are associated with an increased risk of VTE. Patients with high PLR or NLR did not have an increased risk of VTE (odds ratio [OR] 0...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28992766/health-related-quality-of-life-and-association-with-arthropathy-in-greek-patients-with-hemophilia
#10
Agoritsa Varaklioti, Nick Kontodimopoulos, Dimitris Niakas, Anna Kouramba, Olga Katsarou
Health-related quality of life (HRQoL) is increasingly implicated in contemporary hemophilia management. This study focuses on the assessment of HRQoL in Greek patients with hemophilia and the comparison with normative data from the general population, as well as on the extent arthropathy may affect the patients' HRQoL. One hundred and nine adult patients completed the Greek social functioning (SF-36) and Haem-A-QoL questionnaires. Arthropathy was assessed by both the World Federation of Hemophilia clinical score and Pettersson radiological score...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28946755/elevated-dna-damage-oxidative-stress-and-impaired-response-defense-system-inflicted-in-patients-with-myocardial-infarction
#11
Sumayya Shahzad, Asif Hasan, Abul Faiz Faizy, Somaiya Mateen, Naureen Fatima, Shagufta Moin
BACKGROUND: Ischemic tissue damage in myocardial infarction (MI) is allied with the exaggerated production of reactive oxygen species (ROS) beyond the countering capability of chain-breaking radical scavengers, fallouts in the form of oxidatively burdened myocardial tissue. METHODS: One hundred and twenty five patients with MI were included in the study to evaluate the dynamics of redox status of patients by monitoring the antioxidant potential, biomarkers of oxidative stress, lipid indices, RBC membrane damage when compared to healthy individuals in patients with MI congregated on the basis of Global Registry of Acute Coronary Events (GRACE) score, risk factors, and age...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28891316/associations-of-the-abca1-and-lpl-gene-polymorphisms-with-lipid-levels-in-a-hyperlipidemic-population
#12
Fang Tao, Justin Weinstock, Scott A Venners, Jun Cheng, Yi-Hsiang Hsu, Yanfeng Zou, Faming Pan, Shanqun Jiang, Xiangdong Zha, Xiping Xu
We conducted a cross-sectional study to investigate the effects of the adenosine triphosphate-binding cassette transporter 1 (ABCA1) I883M and lipoprotein lipase (LPL) HindIII polymorphisms on lipid levels in patients with hyperlipidemia. A total of 533 patients were enrolled. Serum lipid parameters were determined by an automatic biochemistry analyzer. Genotyping of the ABCA1 I883M and LPL HindIII was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Multiple linear regression analysis was used to estimate the associations between serum lipid levels and the genetic polymorphisms...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28884611/an-evaluation-of-the-activated-partial-thromboplastin-time-waveform
#13
Takeshi Matsumoto, Hideo Wada, Naoki Fujimoto, Junki Toyoda, Yasunori Abe, Kohshi Ohishi, Yoshiki Yamashita, Makoto Ikejiri, Kei Hasegawa, Kei Suzuki, Hiroshi Imai, Kaname Nakatani, Naoyuki Katayama
The activated partial thromboplastin time (APTT) waveform includes several parameters that are related to various underlying diseases. The APTT waveform was examined in various diseases. Regarding the pattern of APTT waveform, a biphasic pattern of the first or second derivative curve (DC) was observed in patients with hemophilia and patients positive for antiphospholipid (aPL) antibodies or coagulation factor VIII (FVIII) inhibitors. The time of the first and second DC and fibrin formation at 1/2 height were prolonged in patients with hemophilia, patients with inhibitors, patients positive for aPL, patients treated with anti-Xa agents, and patients with disseminated intravascular coagulation (DIC)...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28884610/performance-of-current-thromboembolism-risk-assessment-tools-in-patients-with-gastric-cancer-and-validity-after-first-treatment
#14
Harry E Fuentes, L H Paz, Y Wang, D M Oramas, C R Simons, A J Tafur
Patients with gastric cancer (GC) are at higher risk of thromboembolism when compared to other solid tumors. We aim to determine the predictive performance of current venous thromboembolism (VTE) predictive tools and their variability and validity after first treatment. Single institution cohort of GC-treated patients (2010*15). We abstracted predictive tools, validated for VTE prediction in patient with cancer; including the Khorana Score (KRS), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR)...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28884609/impact-of-classical-risk-factors-for-arterial-or-venous-thrombosis-in-patients-with-antiphospholipid-syndrome
#15
Daniel Navarro-Carpentieri, Maria Del Carmen Castillo-Hernandez, Karim Majluf-Cruz, Guillermo Espejo-Godinez, Paola Carmona-Olvera, Manuel Moreno-Hernandez, Yolanda Lugo-García, Jesús Hernandez-Juarez, Luis Loarca-Piña, Irma Isordia-Salas, Abraham Majluf-Cruz
There are classical risk factors associated with arterial thrombosis (AT) or venous thromboembolic disease (VTD). However, less is known about these risk factors and AT or VTD episodes in patients with antiphospholipid syndrome (APS). Our aim was to elucidate whether APS-related thrombotic episodes are associated with the same risk factors as the non-APS population. We gathered demographics, medical history, complications, and causes of death associated with the risk factors for AT or VTD in patients with APS...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28884608/analysis-of-risk-factors-of-stroke-and-venous-thromboembolism-in-females-with-oral-contraceptives-use
#16
Petr Dulicek, Eva Ivanova, Milan Kostal, Petr Sadilek, Martin Beranek, Pavel Zak, Jana Hirmerova
Thrombotic diathesis has been a well-known complication of oral contraceptive use for more than 50 years. This is true not only for venous thrombosis but also for an arterial one. The etiology is usually multifactorial and depends on several additional risk factors. We analyzed the prevalence of inherited and acquired thrombophilia in a cohort of 770 females who had a thrombotic event in association with oral contraceptive use (700 women with venous thromboembolism [VTE], 70 with stroke). Moreover, we tried to identify additional risk factors...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28870084/comparison-between-thromboelastography-and-conventional-coagulation-tests-in-surgical-patients-with-localized-prostate-cancer
#17
Zhengwei Wang, Jing Li, Qingwei Cao, Lei Wang, Fengzhi Shan, Houyi Zhang
We aimed to examine hypercoagulable and hypocoagulable conditions in patients with prostate cancer using thromboelastography (TEG) and correlate TEG parameters with conventional coagulation test. The t test was used for comparing TEG parameters and routine coagulation results. Spearman rank-order correlation was used to describe the relationship of TEG and conventional tests. Sensitivity, specificity, positive predictive values, and negative predictive values were determined for bleeding and thrombosis. Totally, 20 patients had active bleeding postoperatively, 16 of whom showed hypocoagulation on TEG test and 9 of whom showed hypocoagulation by routine coagulation test ( P = ...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28774196/the-clinical-utility-of-the-heparin-neutralization-assay-in-the-diagnosis-of-heparin-induced-thrombocytopenia
#18
Gang Zheng, Michael B Streiff, Clifford M Takemoto, Jennifer Bynum, Elise Gelwan, Jayesh Jani, Danielle Judge, Thomas S Kickler
Heparin-induced thrombocytopenia (HIT) remains diagnostically challenging. Immunoassays including PF4/heparin enzyme-linked immunosorbent assay (ELISA) have high sensitivity but low specificity. Whether the heparin neutralization assay (HNA) improves the diagnostic accuracy of the PF4/heparin ELISA for HIT is uncertain. In this study, to assess its clinical utility and evaluate whether it improves the diagnostic accuracy for HIT, we implemented HNA in conjunction with PF4/heparin ELISA over a 1-year period...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28752769/mutation-spectrum-and-genotype-phenotype-analyses-in-a-pakistani-cohort-with-hemophilia-b
#19
Muhammad Tariq Masood Khan, Arshi Naz, Jawad Ahmed, Tahir Shamsi, Shariq Ahmed, Nisar Ahmed, Ayisha Imran, Nazish Farooq, Muhammad Tariq Hamayun Khan, Abid Sohail Taj
This study aimed to (1) identify F9 genetic alterations in patients with hemophilia B (HB) of Pakistani origin and (2) determine the genotype-phenotype relationships in these patients. Diagnosed cases of HB were identified through registries at designated tertiary health-care centers across the country. Consenting patients were enrolled into the study. The factor IX (FIX) coagulation activity (FIX:C) and key clinical features were recorded. Direct sequencing of F9 was carried out in all patients. All the variants identified were analyzed for functional consequences employing in silico analysis tools...
July 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29514466/postthrombotic-syndrome-in-patients-treated-with-rivaroxaban-or-warfarin-for-venous-thromboembolism
#20
Craig I Coleman, Jan Beyer-Westendorf, Thomas J Bunz, Charles E Mahan, Alex C Spyropoulos
Postthrombotic syndrome (PTS) is a frequent complication of venous thromboembolism (VTE). Using MarketScan claims data from January 2012 to June 2015, we identified adults with a primary diagnosis code for VTE during a hospitalization/emergency department visit, ≥6 months of insurance coverage prior to the index event and newly started on rivaroxaban or warfarin within 30 days of the index VTE. Patients with <4-month follow-up postindex event or a claim for any anticoagulant during 6-month baseline period were excluded...
May 2018: Clinical and Applied Thrombosis/hemostasis
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