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Clinical and Applied Thrombosis/hemostasis

Wen-Ya Lin, Jiaan-Der Wang, Yu-Tse Tsan, Wei-Cheng Chan, Kwok-Man Tong, Shin-Tsu Chang, Yuan-Yang Cheng
Recurrent hemarthrosis in patients with hemophilia (PWH) results in chronic arthropathy requiring total joint replacement (TJR). This study aimed to compare the difference in TJR rate between patients with hemophilia A (HA) and hemophilia B (HB). A final total of 935 PWH (782 HA and 153 HB) without inhibitors were collected from the Taiwan's National Health Insurance Research Database between 1997 and 2013. Demographics, clinical characteristics, and TJR rate were compared between the 2 groups. The annual use of clotting factor concentrate was not different between HA and HB groups ( P = ...
September 13, 2018: Clinical and Applied Thrombosis/hemostasis
Clara Ting, Katelyn W Sylvester, James W Schurr
Due to variable pharmacokinetic properties, therapeutic anticoagulation with continuous unfractionated heparin (UFH) requires ongoing laboratory monitoring, generally with activated partial thromboplastin time (aPTT). In the ambulatory setting, clinicians who manage warfarin therapy often use time in the therapeutic range (TTR) to estimate a percentage of time the international normalized ratio is therapeutic. We applied the TTR concept to aPTT monitoring for therapeutic UFH and used 2 methodologies for estimation: percentage of aPTT values in range (%aIR) and a modification of the Rosendaal method (mod-Rosendaal)...
September 13, 2018: Clinical and Applied Thrombosis/hemostasis
Mustafa Çetiner, Hasan Emre Aydin, Merve Güler, Sibel Canbaz Kabay, Yaşar Zorlu
The objective of our study is to detect the patient group that will most benefit from intravenous (IV) thrombolytic therapy by showing predictive factors of good functional outcomes. The present study covers 88 patients who were admitted to our clinic within the first 4.5 hours from the onset of stroke symptoms, diagnosed with acute ischemic stroke and who received IV thrombolytic therapy between May 2014 and June 2017 as a result of a retrospective analysis of a database prospectively collected. The patients with a score of ≤2 on modified Rankin scale within 3 months were accepted as good functional outcome and those with a score of >2 were accepted as poor functional outcome...
September 13, 2018: Clinical and Applied Thrombosis/hemostasis
Chun-Ming Zhao, Yu Zhang, Si-Dong Yang, Ai-Bing Huang, Zong-Min Liang, Jian Wu, Qian Chen
Lower limb deep vein thrombosis (DVT) is not an uncommon postoperative complication of spinal fusion surgery. However, the related risk factors identified in previous studies remain controversial. This study aimed to investigate risk factors for lower limb DVT in patients with single-level lumbar fusion surgery. Between January 2010 and December 2016, a total of 710 patients undergoing lumbar fusion were recruited for this study, including 172 males and 538 females (aged 18-75 years). Deep vein thrombosis was detected by ultrasonography...
September 10, 2018: Clinical and Applied Thrombosis/hemostasis
Xiaolan Chen, Lei Pan, Hui Deng, Jingyuan Zhang, Xinjie Tong, He Huang, Min Zhang, Jianlin He, Joseph A Caprini, Yong Wang
The current venous thromboembolism (VTE) guidelines recommend all patients to be assessed for the risk of VTE using risk assessment models (RAMs). The study was to evaluate the performance of the Caprini and Padua RAMs among Chinese hospitalized patients. We reviewed data from 189 patients with deep venous thrombosis (DVT) and 201 non-DVT patients. Deep venous thrombosis risk factors were obtained from all patients. The sensitivity and specificity of the Caprini and Padua scores for all patients were calculated...
September 9, 2018: Clinical and Applied Thrombosis/hemostasis
Toshiaki Iba, Makoto Arakawa, Yoshifumi Ohchi, Takao Arai, Koichi Sato, Hideo Wada, Jerrold H Levy
For success in clinical trials, eliminating inclusion of patients with irreversible recovery is important. The purpose of this study was to identify the patient population who do not survive for more than 3 days. A total of 449 patients with sepsis suspected of having disseminated intravascular coagulation (DIC) and treated with antithrombin were examined. The patient characteristics, baseline sequential organ failure assessment (SOFA) score, DIC score, and hemostatic markers were retrospectively analyzed in relation to early death (died within 3 days)...
September 9, 2018: Clinical and Applied Thrombosis/hemostasis
Walter Jeske, Ahmed Kouta, Rick Duff, Varun Rangnekar, Manoj Niverthi, Debra Hoppensteadt, Jawed Fareed, Yiming Yao
Although pharmaceutical grade heparin is obtained almost exclusively from porcine intestinal mucosa, there is interest in diversifying heparin sourcing to address potential supply shortages and economically motivated adulteration. Since ovine-derived heparin is structurally similar to porcine heparin, it is expected that ovine-derived low-molecular-weight heparin (LMWH) will be comparable to porcine-derived LMWH. This study compared the pharmacokinetic (PK) behavior of 3 batches of ovine LMWH with that of enoxaparin in nonhuman primates...
September 9, 2018: Clinical and Applied Thrombosis/hemostasis
Christoph Raspé, Maximilian Besch, Efstratios I Charitos, Lilit Flöther, Michael Bucher, Florian Rückert, Hendrik Treede
We aimed to detect alterations and deficits in hemostasis during cardiac surgery with cardiopulmonary bypass (CPB) using point-of-care-supported coagulation analysis (rotational thromboelastometry, impedance aggregometry), in addition to single factor assays for the measurement of fibrinogen (FI) and factor XIII (FXIII) levels. Forty-one patients scheduled for elective cardiac surgery with CPB were enrolled in this observational study. Perioperative measurement (pre-, postheparin, 30-minutes before the end of bypass, 1-hourpostoperatively) of standard laboratory variables, additional rotational thromboelastometry (ROTEM; International GmbH, Munich, Germany), Multiplate analysis (Roche, Switzerland), and an assay of FXIII activity were performed as well as the collection of epidemiological data and blood loss...
September 9, 2018: Clinical and Applied Thrombosis/hemostasis
Sariya Udayachalerm, Sasivimol Rattanasiri, Teeranan Angkananard, John Attia, Nakarin Sansanayudh, Ammarin Thakkinstian
New oral anticoagulants (NOACs; ie, direct thrombin inhibitor [DTI] and factor Xa [FXa] inhibitors) were used as alternatives to warfarin. Specific antidotes (idarucizumab for dabigatran and andexanet alfa for FXa inhibitors) and hemostatic reversal agents were used for lowering bleeding, but their efficacies were still uncertain. The objectives of this study were to estimate and compare the efficacy of NOAC antidotes on bleeding reversal and death. Studies were identified from MEDLINE and Scopus databases until May 2018...
September 3, 2018: Clinical and Applied Thrombosis/hemostasis
Jacob E Hood, Sumith Yesudasan, Rodney D Averett
Although in vivo studies have been conducted in the past to determine hyperglycemic effects and influence on clotting risk in patients with diabetes, the true extent of hyperglycemia on unstable and spontaneous clot formation remains highly debated. Factors such as increased glycation, elevated fibrinogen concentration, elevated prothrombin levels, and decreased plasminogen are known to influence fibrin conversion, clot morphology, and thrombus formation in these individuals. In this regard, the isolated effects of hyperglycemia on irregular fibrin clot formation were investigated in a controlled fibrinogen system...
August 16, 2018: Clinical and Applied Thrombosis/hemostasis
Denise Bichuyen Mai, Mary R Smith, William T Gunning
The purpose of this study was to determine the reliability of test results dependent upon blood and plasma sample stability when shipped by airfreight courier for reference laboratory assessment. Of particular interest was evaluation of von Willebrand profile assays and platelet dense granule storage pool analysis. Peripheral venous blood was obtained from healthy volunteers. von Willebrand factor (VWF) activity, VWF antigen, and factor VIII coagulant activity assays were performed immediately following venipuncture with additional aliquots of plasma frozen and stored at -70°C for subsequent analysis 48 hours later...
August 16, 2018: Clinical and Applied Thrombosis/hemostasis
Qi Wang, Lijuan Cao, Guangying Sheng, Hongjie Shen, Jing Ling, Jundan Xie, Zhenni Ma, Jie Yin, Zhaoyue Wang, Ziqiang Yu, Suning Chen, Yiming Zhao, Changgeng Ruan, Lijun Xia, Miao Jiang
Inherited thrombocytopenia is a group of hereditary diseases with a reduction in platelet count as the main clinical manifestation. Clinically, there is an urgent need for a convenient and rapid diagnosis method. We introduced a high-throughput, next-generation sequencing (NGS) platform into the routine diagnosis of patients with unexplained thrombocytopenia and analyzed the gene sequencing results to evaluate the value of NGS technology in the screening and diagnosis of inherited thrombocytopenia. From a cohort of 112 patients with thrombocytopenia, we screened 43 patients with hereditary features...
August 13, 2018: Clinical and Applied Thrombosis/hemostasis
Uğur Berber, Mehmet Akif Özdemir, Ekrem Unal, Serpil Taheri, Serkan Yildiz, Keziban Korkmaz Bayramov, Yunus Güler, Hüseyin Per
Intracranial hemorrhage due to vitamin K deficiency is a serious disease that can lead to morbidity, mortality, and mental retardation. Our goal in this study is to determine the frequency of VKORC1-1639 G>A polymorphism in patients who have undergone intracranial hemorrhage due to vitamin K deficiency bleeding (VKDB). To study VKORC1-1639 G>A polymorphism, blood was drawn from patients (n = 51, age 8:0 ± 6:5 years) followed at the Pediatric Neurology and Hematology section, Faculty of Medicine, Erciyes University, between 1990 and 2016, diagnosed with VKDB as idiopathic or from patients diagnosed with intracranial hemorrhage due to secondary vitamin K deficiency and also from volunteers (n = 51, age 11 ± 4...
August 13, 2018: Clinical and Applied Thrombosis/hemostasis
Marijan Bosevski, Gorjan Krstevski, Atanas Gjorgievski, Irena Mitevska, Elizabeta Srbinovska Kostovska
The article's aim was to determine predictors for short- and long-term prognosis of patients with pulmonary embolism (PE). Cohort prospective study based on the National registry on venous thromboembolism. Eighty-four patients with PE, on age 60.3 + 12.5 years, were selected and followed up in a prospective study. Pulmonary embolism was confirmed by computed tomography angiography in all the patients, while deep venous thrombosis was confirmed by ultrasound in 21 patients. Study population was followed up for 6...
July 26, 2018: Clinical and Applied Thrombosis/hemostasis
Barbora Korpallová, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, František Kovář, Peter Kubisz, Ján Staško, Marián Mokáň
The monitoring of coagulation by viscoelastometric methods-thromboelastography and rotational thromboelastometry-may detect the contributions of cellular and plasma components of hemostasis. These methods might overcome some of the serious limitations of conventional laboratory tests. Viscoelastic testing can be repeatedly performed during and after surgery and thus provides a dynamic picture of the coagulation process during these periods. Several experiences with the use of these methods in cardiovascular surgery have been reported, but there is perspective for more frequent use of these assays in the assessment of platelet response to antiplatelet therapy and in the assessment of coagulation in patients on long-term dabigatran therapy...
July 24, 2018: Clinical and Applied Thrombosis/hemostasis
Juraj Sokol, Maria Skerenova, Jela Ivankova, Tomas Simurda, Jan Stasko
The aim of this study was to evaluate the genetic variability of the selected single nucleotide polymorphisms (SNPs) and examine the association between these SNPs and risk for deep vein thrombosis (DVT) in patients with sticky platelet syndrome (SPS). We examined 84 patients with SPS and history of DVT and 101 healthy individuals. We were interested in 2 SNPs within platelet endothelial aggregation receptor 1 (PEAR1) gene (rs12041331 and rs12566888), 2 SNPs within mkurine retrovirus integration site 1 gene (rs7940646 and rs1874445), 1 SNP within Janus kinase 2 gene (rs2230722), 1 SNP within FCER1G gene (rs3557), 1 SNP within pro-platelet basic protein (rs442155), 4 SNPs within alpha2A adrenergic receptor 2A (ADRA2A; rs1800545, rs4311994, rs11195419, and rs553668), and 1 SNP within sonic hedgehog gene (rs2363910)...
October 2018: Clinical and Applied Thrombosis/hemostasis
Valery Leytin, Armen V Gyulkhandanyan, John Freedman
Platelets may selectively execute apoptosis (PL-Apo), activation (PL-Act), and both or no responses when exposed to different chemical agents, shear stresses, and stored under blood banking conditions. Appropriate diagnosis of PL-Apo is an important issue of platelet physiology investigations. However, in diagnosing PL-Apo, there is a risk of a false-negative or false-positive diagnosis. The goal of the current review is to present recommendations that may help to avoid incorrect PL-Apo diagnosis. Analyzing reported studies, we recommend (1) using platelet-rich plasma rather than isolated platelets to minimize artificial stimulation of PL-Apo during platelet isolation, (2) using established optimal conditions for stimulation of PL-Apo and/or PL-Act, (3) using a panel of PL-Apo and PL-Act markers, and (4) appropriate positive and negative controls for quantification of PL-Apo and PL-Act responses...
October 2018: Clinical and Applied Thrombosis/hemostasis
Amanda Walborn, Mark Williams, Jawed Fareed, Debra Hoppensteadt
The development of coagulation abnormalities is common in patients with sepsis. Sepsis-associated coagulopathy (SAC) is typically diagnosed by prothrombin time (PT) prolongation or elevated international normalized ratio (INR) in conjunction with reduced platelet count. INR is also used to monitor warfarin-treated patients. However, due to the different natures of SAC and warfarin anticoagulation, it is likely that the same INR value provides different information in these two patient populations. The purpose of this study was to compare measures of coagulation function and clotting factor levels in patients with SAC to those observed in patients receiving warfarin anticoagulation...
October 2018: Clinical and Applied Thrombosis/hemostasis
Zahra Ghafari
No abstract text is available yet for this article.
October 2018: Clinical and Applied Thrombosis/hemostasis
Jessica Morales-Ortíz, Matthew T Rondina, Samuel M Brown, Colin Grissom, A Valance Washington
We have previously demonstrated that elevated levels of soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) modulate sepsis-induced inflammation and positively correlate with disseminated intravascular coagulation (DIC). Here, we evaluate the clinical implications of plasma sTLT-1 in acute respiratory distress syndrome (ARDS), which is common in sepsis patients. Soluble TLT-1 levels in the plasma of ARDS patients (n = 20) were determined by slot blot analysis and were compared with clinical parameters to identify significant associations...
October 2018: Clinical and Applied Thrombosis/hemostasis
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