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Clinical and Applied Thrombosis/hemostasis

Abrar Ahmad, Kristina Sundquist, Bengt Zöller, Peter J Svensson, Jan Sundquist, Ashfaque A Memon
Thrombomodulin (THBD) serves as a cofactor for thrombin-mediated activation of anticoagulant protein C pathway. Genetic aberrations in THBD have been studied in arterial and venous thrombosis. However, genetic changes in THBD and their role in the risk assessment of recurrent venous thromboembolism (VTE) are not well understood. The aim of the present study was to identify the genetic aberrations in THBD and their association with the risk of VTE recurrence in a prospective population-based study. We sequenced the entire THBD gene, first in selected patients with VTE (n = 95) by Sanger sequencing and later validated those polymorphisms with minor allele frequency (MAF) ≥5% in the whole study population (n = 1465 with the follow-up period of 1998-2008) by Taqman polymerase chain reaction...
May 2017: Clinical and Applied Thrombosis/hemostasis
Nikhil Kapil, Yvonne H Datta, Naila Alakbarova, Eric Bershad, Magdy Selim, David S Liebeskind, Ornina Bachour, Gundu H R Rao, Afshin A Divani
Ischemic stroke represents one of the leading causes of death and disability in both the United States and abroad, particularly for patients with prior ischemic stroke or transient ischemic attack (TIA). A quintessential aspect of secondary stroke prevention is the use of different pharmacological agents, mainly antiplatelets and anticoagulants. Antiplatelets and anticoagulants exhibit their effect by blocking the activation pathways of platelets and the coagulation cascade, respectively. Clinical trials have demonstrated the safety and efficacy of antiplatelets for noncardioembolic stroke prevention, while anticoagulants are more often used for cardioembolic stroke prevention...
May 2017: Clinical and Applied Thrombosis/hemostasis
Melih Yuksel, Turgay Isik, Ibrahim Halil Tanboga, Erkan Ayhan, Mehmet Emre Erimsah, Selim Topcu, Selami Demirelli, Enbiya Aksakal, Serdar Sevimli
AIM: The aim of this study is to examine the relationship between initial magnesium (Mg) levels, electrocardiographic no-reflow, and long-term mortality in patients who underwent primary percutaneous coronary intervention (pPCI) due to ST-segment elevation myocardial infarction (STEMI). METHODS: A total of 111 patients with pPCI participated in the study. Magnesium and high-sensitive C-reactive protein (hs-CRP) were measured. The sum of ST-segment elevation was measured immediately before and 60 minutes after the restoration of coronary flow...
May 2017: Clinical and Applied Thrombosis/hemostasis
Mirjana Bećarević, Velibor Čabarkapa, Mirjana Đerić, Svetlana Ignjatović
OBJECTIVE: Antiphospholipid antibodies (aPL Abs) represented an independent factor that was associated with the occurrence and/or progression of nephropathy in patients with antiphospholipid syndrome, but their role in diabetic nephropathy is not elucidated. Therefore, we evaluated the association of aPL Abs with the renal impairment parameters in patients with diabetic nephropathy. METHODS: Concentrations of analyzed antibodies were measured by enzyme-linked immunosorbent assay...
May 2017: Clinical and Applied Thrombosis/hemostasis
Kang Li, Yanhong Liu, Scott A Venners, Yi-Hsiang Hsu, Shanqun Jiang, Justin Weinstock, Yiyang Sun, Binyan Wang, Xiping Xu
OBJECTIVES: To investigate whether LEP G2548A and LEPR Q223R polymorphisms influence serum lipid levels and whether the 2 polymorphisms affect the efficacy of simvastatin treatment in Chinese patients with primary hyperlipidemia. METHODS: We used an extreme sampling approach by selecting 212 individuals from the top and bottom 15% of adjusted lipid-lowering response residuals to simvastatin (n = 106 in each group of good or bad response) from a total of 734 samples with primary hyperlipidemia...
May 2017: Clinical and Applied Thrombosis/hemostasis
Artur Słomka, Milena Świtońska, Władysław Sinkiewicz, Ewa Żekanowska
AIM: The goal of this study was to determine the levels of factor VII (FVII), factor VIIa-antithrombin complexes (FVIIa-AT), total tissue factor (TF), and tissue factor-bearing microparticles (MPs-TF) in patients with acute ischemic stroke. Further, we sought evidence of an association between hemostatic markers, time of blood sampling, type of treatment, and patient outcomes. METHODS: Venous blood samples were collected from 33 patients on the first day and on the seventh day after stroke diagnosis...
May 2017: Clinical and Applied Thrombosis/hemostasis
Abdelrahman A Nimeri, Maysoon M Gamaleldin, Karen L McKenna, Nicolas P Turrin, Bisher O Mustafa
BACKGROUND: Sheikh Khalifa Medical City's (SKMC) surgery institute was identified as a high outlier in the incidence of venous thromboembolism (VTE; deep vein thrombosis [DVT] and pulmonary embolism [PE]) based on the semiannual report of the American College of Surgeon's National Surgical Quality Improvement Program (ACS NSQIP) in June 2010. AIM: To report our rates of VTE at SKMC, the results, and 5-year follow-up after an ACS NSQIP quality improvement program...
May 2017: Clinical and Applied Thrombosis/hemostasis
Hamid Amoozgar, Maedeh Fath, Parisa Jooya, Mehran Karimi
There are conflicting reports about the protective effect of hemophilia on the occurrence of ischemic heart disease. This study focuses on evaluation of heart function in patients with hemophilia. Cross-sectional, case-control study was done on all patients with hemophilia A or B who came to hemophilia center, and data were compared to controls. The data were collected from their charts, and heart function was evaluated by 2-dimensional, Doppler and pulse tissue Doppler. The serum troponin I level was measured in all patients as a marker of myocardial damage...
May 2017: Clinical and Applied Thrombosis/hemostasis
Ozcan Basaran, Nesrin Filiz Basaran, Edip Guvenc Cekic, Ibrahim Altun, Volkan Dogan, Gurbet Ozge Mert, Kadir Ugur Mert, Fatih Akin, Mustafa Ozcan Soylu, Kadriye Memic Sancar, Murat Biteker
INTRODUCTION: Inappropriate use of oral anticoagulants (OACs) have not been well investigatedand, however, may be frequent in real-world practice in patients with nonvalvular atrial fibrillation (NVAF). This study was designed to evaluate the prescription patterns and appropriateness of OACs in patients with NVAF in real-world clinical settings. METHODS: We performed a prospective, observational study (NCT02366338). A total of 148 patients with NVAF were screened for OAC prescription...
May 2017: Clinical and Applied Thrombosis/hemostasis
Jens Kristian Baelum, Espen Ellingsen Moe, Mads Nybo, Pernille Just Vinholt
BACKGROUND: Venous thromboembolism (VTE) is a frequent and potentially lethal condition. Venous thrombi are mainly constituted of fibrin and red blood cells, but platelets also play an important role in VTE formation. Information about VTE in patients with thrombocytopenia is, however, missing. OBJECTIVES: To identify VTE risk factors and describe treatment and outcome (bleeding episodes and mortality) in patients with thrombocytopenia. PATIENTS/METHODS: Patients with thrombocytopenia (platelet count <100 × 10(9)/L) admitted to Odense University Hospital, Denmark, between April 2000 and April 2012 were included...
May 2017: Clinical and Applied Thrombosis/hemostasis
Burak Ayça, Didem Kafadar, Murat Avsar, I İlker Avci, Fatih Akın, Ertugrul Okuyan, M Hakan Dinckal
BACKGROUND: The impact of fat distribution, muscle mass, and muscle strength on no-reflow and severity of coronary artery disease in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. OBJECTIVE: To investigate association between muscle strength and fat and muscle mass and severity of coronary atherosclerosis. METHODS: We included 218 patients with STEMI who had undergone primary percutaneous coronary intervention...
May 2017: Clinical and Applied Thrombosis/hemostasis
Wael Alkhiary, Nesreen E Morsy, Aida M Yousef, Amr Mohamed El-Saddik, Eman O Arram
Obstructive sleep apnea syndrome (OSAS) is a risk factor for arterial thrombosis and cardiovascular morbidity. Activated platelets play key roles in the development of atherothrombosis, thus may be involved in these complications of OSAS. Herein, we evaluated the relationship between severity of OSAS and the degree of platelet aggregates as a marker of activated platelets in 64 patients with OSAS. Platelet aggregations were determined by means of optical aggregometry, using adenosine diphosphate (ADP) as an agonist...
May 2017: Clinical and Applied Thrombosis/hemostasis
Nasiredin Sadeghi, Massimo Iacobelli, Behroz Vaziri, Daniel Kahn, Debra Hoppensteadt, Nil Guler, Jawed Fareed
Recombinant factor VIIa (rFVIIa) is used in the management of bleeding in patients with hemophilia. A generic biosimilar version of NovoSeven is also developed (AryoSeven). To compare the activation profile of NovoSeven and AryoSeven, 2 commercially available protein complex concentrates (PCCs) were used. Profilnine activated by RecombiPlasTin 2G resulted in conversions of prothrombin to prethrombin and thrombin at 5 to 30 minutes. However, addition of rFVIIa at final concentration range of 0.25 to 0.5 µg/mL to the same mixture resulted in total conversion of prothrombin to thrombin with a doublet at 36 kDa...
April 2017: Clinical and Applied Thrombosis/hemostasis
Rolf Dario Frank, Regina Lanzmich, Philipp K Haager, Ulrich Budde
Aortic valve stenosis (AVS) is the most common valve disease in adults. Severe forms are associated with acquired von Willebrand syndrome (aVWS) with loss of the largest von Willebrand factor (VWF) multimers. Diagnostic gold standard is the VWF multimer analysis. Valve replacement rapidly restores the VWF structure. Uncertainty exists if this effect is permanent and how functional VWF assays perform compared with multimer analysis. We studied 21 consecutive patients with severe AVS before and 6 to 18 months after valve surgery and compared them with 14 controls without valve disease referred for coronary angiography...
April 2017: Clinical and Applied Thrombosis/hemostasis
Ercan Varol
No abstract text is available yet for this article.
April 2017: Clinical and Applied Thrombosis/hemostasis
Cristina Legnani, Michela Cini, Mirella Frascaro, Giuseppina Rodorigo, Michelangelo Sartori, Benilde Cosmi
In patients presenting non-high clinical pretest probability (PTP), a negative d-dimer can exclude venous thromboembolism without imaging tests. However, each d-dimer assay should be validated in prospective studies. We evaluated an automated d-dimer immunoassay using the Sclavo Auto d-dimer (Sclavo Diagnostics Int, Sovicille, Italy) provided by Dasit Diagnostica (Cornaredo, Milan, Italy). Three hundred two consecutive outpatients suspected of leg deep vein thrombosis (DVT) with non-high PTP were included. The Sclavo Auto d-dimer assay was evaluated on 2 analyzers (Sysmex CA-7000 and Sysmex CS-2100; Sysmex Corporation, Kobe, Japan, provided by Dasit)...
April 2017: Clinical and Applied Thrombosis/hemostasis
Alina Mărginean, Claudia Bănescu, Valeriu Moldovan, Alina Scridon, Mihai Mărginean, Rodica Bălaşa, Smaranda Maier, Mariana Ţăruşi, Minodora Dobreanu
INTRODUCTION: Clopidogrel is an antiplatelet drug widely used in patients with acute coronary syndromes or stroke. Despite adequate antiplatelet therapy, some patients develop acute ischemic events. This is partly attributed to the fact that they have poor inhibition of platelet reactivity, despite treatment. This study aimed to assess the impact of clinical and demographic variables and of cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms on platelet response to clopidogrel evaluated using impedance aggregometry in an East European population...
April 2017: Clinical and Applied Thrombosis/hemostasis
Sani Namik Murat, Mikail Yarlioglues, Ibrahim Etem Celik, Alparslan Kurtul, Mustafa Duran, Alparslan Kilic, Fatih Oksuz
In-stent restenosis (ISR) is a common clinical problem in patients with coronary artery disease treated with percutaneous coronary intervention. Inflammatory process plays a pivotal role in the development of ISR. Both lymphocytes and monocytes are associated with inflammatory status. Recently, it has been shown that the lymphocyte-to-monocyte ratio (LMR) is a novel inflammatory marker. We aimed to investigate the association of serum LMR levels and ISR in patients undergoing bare-metal stent (BMS) implantation...
April 2017: Clinical and Applied Thrombosis/hemostasis
Yihong Sun, Yitong Wang, Juan Jiang, Lina Wang, Dayi Hu
We investigated the risk of stroke associated with renal dysfunction and the impact of warfarin therapies in Chinese patients with nonvalvular atrial fibrillation (NVAF). Information was collected on age, sex, height, weight, type of atrial fibrillation, and serum creatinine within the previous 6 months, together with the variables needed to calculate the CHADS2 score. For patients not taking warfarin, reasons why not were recorded. Three thousand seventeen eligible patients with NVAF, mean (1 standard deviation [SD]) age of 67...
April 2017: Clinical and Applied Thrombosis/hemostasis
Sabahattin Gündüz, Mehmet Özkan, Mahmut Yesin, Macit Kalçık, Mustafa Ozan Gürsoy, Süleyman Karakoyun, Mehmet Ali Astarcıoğlu, Ahmet Çağrı Aykan, Tayyar Gökdeniz, Murat Biteker, Nilüfer Ekşi Duran, Mustafa Yıldız
BACKGROUND: The outcomes of thrombolytic therapy (TT) in elderly patients with prosthetic valve thrombosis (PVT) have not been evaluated previously. We investigated the outcomes of low-dose and slow infusion TT strategies in elderly patients with PVT. METHODS: Twenty-seven (19 female) patients aged ≥65 years (median: 70 years, range: 65-82 years) were treated with repeated TT agents for PVT. The TT regimens included 24-hour infusion of 1.5 million units of streptokinase in 2 patients, 6-hour infusion of 25 mg recombinant tissue plasminogen activator (t-PA) in 12 patients, and 25-hour infusion of 25 mg t-PA in 13 patients...
April 2017: Clinical and Applied Thrombosis/hemostasis
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