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Journal of Interferon & Cytokine Research

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https://www.readbyqxmd.com/read/28854064/microrna-141-is-involved-in-ulcerative-colitis-pathogenesis-via-aiming-at-cxcl5
#1
Mao Cai, Suping Chen, Wanle Hu
MicroRNAs (miRNAs) are gene expression's important posttranscriptional regulators. The precise function of miRNAs in ulcerative colitis (UC) is not entirely known. Our investigation's aim was to identify miRNAs induced in patients with active UC and to evaluate miR-141 influences on ameliorating intestinal inflammation. The miRNA expression profiles in patients suffering active UC (n = 15) and healthy individuals used as control (n = 13) were assessed adopting miRNA microarrays. Via quantitative real-time polymerase chain reaction, miR-141 expression was confirmed...
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28829282/parthenolide-promotes-differentiation-of-osteoblasts-through-the-wnt-%C3%AE-catenin-signaling-pathway-in-inflammatory-environments
#2
Xufang Zhang, Qingpiao Chen, Jianwei Liu, Chen Fan, Qi Wei, Zetao Chen, Xueli Mao
Periodontitis is a progressive inflammatory disease initiated by bacterial biofilm adhering to the tooth surface. If left untreated, periodontitis may lead to tooth loss and destruction of the alveolar bone. Regaining the lost alveolar bone is a clinical challenge because of the limited differentiation ability of osteoblasts in inflammatory environments. We have previously shown the anti-inflammatory and antiosteoclastogenic activities of parthenolide (PTL) in human periodontal ligament-derived cells by inhibiting nuclear factor kappa B (NF-κB) signaling, indicating its potential for periodontitis treatment...
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28829246/ppe27-in-mycobacterium-smegmatis-enhances-mycobacterial-survival-and-manipulates-cytokine-secretion-in-mouse-macrophages
#3
Guoping Yang, Tao Luo, Changfeng Sun, Jinning Yuan, Xuan Peng, Chunxi Zhang, Xiaoqian Zhai, Lang Bao
Mycobacterium tuberculosis PE/PPE family proteins play a vital role in antigenic diversity, host-pathogen interactions, and immune evasion. As secreted by ESX-5 system, M. tuberculosis PPE27 is related to the growth and virulence of the bacilli. In this study, we expressed PPE27 in the nonpathogenic fast growing Mycobacterium smegmatis. We found that the recombinant strain exhibits higher survival rate under several hostile conditions in vitro and longer persistence in mouse tissues. The survival of the recombinant strains was also enhanced in the mouse macrophage ANA-1, accompanied by higher level of host cell death, higher secretion of tumor necrosis factor-alpha, and a slightly higher amount of interleukin (IL)-1β, which could be abolished by the nuclear factor-κB, p38, and ERK inhibitors...
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28829242/baicalin-inhibits-inflammatory-responses-to-interleukin-1%C3%AE-stimulation-in-human-chondrocytes
#4
Deguo Xing, Hongwei Gao, Zhonghao Liu, Yangyang Zhao, Mingzhi Gong
A mix of flavonoids comprising baicalin (BA) and catechin showed effective impacts on controlling the progress of knee osteoarthritis (OA). However, little is known about the underlying mechanisms. The influences of BA on the transcriptional levels of a series of proinflammatory genes were measured using real-time reverse transcription and polymerase chain reaction (RT-PCR). The expressions of proteins involved in nuclear factor-κB (NF-κB) activation were detected by Western blot. The in vitro results were confirmed in a mouse OA model...
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28727936/helper-t-cells-and-cancer-associated-inflammation-a-new-direction-for-immunotherapy
#5
Chen Dong
CD4(+) helper T cells are critical regulators in immunity and inflammation. Growing evidence has indicated their involvement in cancer, by shaping the tumor microenvironment. In this study, I summarize latest literature on Th2 and Th17 cells in cancer-associated inflammation and propose that they may be targeted for cancer immunotherapy.
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28696819/heterogeneity-and-stability-in-foxp3-regulatory-t-cells
#6
Booki Min
Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and immunity against self- and foreign antigens. The failure of Tregs to properly function is the direct cause of systemic and chronic inflammation as well as immune suppression. It is now evident that Tregs are highly heterogeneous populations depending on the surface phenotypes, cytokine profiles, and anatomical locations. Yet, our understanding of the cellular and molecular pathways underlying such heterogeneity is very limited...
September 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28777714/serious-adverse-events-with-sofosbuvir-combined-with-interferon-and-ribavirin-real-life-egyptian-experience
#7
Tamer Elbaz, Magdy Elserafy, Wafaa Elakel, Mohammad A Mohey, Mahmoud Abdo, Mohamed Hassany, Mai Mehrez, Mahmoud Abouelkhair, Ayman Yosry, Ashraf Omar, Imam Waked, Manal Hamdy Elsayed, Zakaria Mahran, Yahia Elshazly, Noman Elgarem, Aly Gaballa, Wahid Doss, Gamal Esmat
Viral hepatitis is a serious problem worldwide that was under-recognized till recently. The prevalence of chronic hepatitis C virus (HCV) is estimated to be 180 million people worldwide. Treatment of chronic HCV using combined pegylated interferon and ribavirin (PEG/RIBA) has long been the standard of care with modest response. In our study, we will report the real-life experience of serious adverse events (SAEs) that were reported by the National Committee for Control of Viral Hepatitis (NCCVH, Cairo, Egypt) program while treating chronic HCV using the triple therapy, sofosbuvir combined with pegylated interferon and ribavirin (PEG/RIBA/SOF), which led to premature discontinuation of treatment...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28731786/high-post-treatment-%C3%AE-fetoprotein-levels-and-aspartate-aminotransferase-to-platelet-ratio-index-predict-hepatocellular-carcinoma-in-hepatitis-c-virus-decompensated-cirrhotic-patients-with-sustained-virological-response-after-antiviral-therapy
#8
Fanpu Ji, Rui Zhou, Wenjun Wang, Dan Bai, Caini He, Zhifang Cai, Yuan Shen, Shengbang Wang, Hong Deng, Zongfang Li
Although eradication of hepatitis C virus (HCV) decreases the risk of hepatocellular carcinoma (HCC) development, a considerable level of risk remains in cirrhotic patients with advanced liver disease. Yet, data for the effect of serum markers on HCC development in this population after viral eradication are still lacking. Seventy-eight consecutive patients with HCV infection and decompensated cirrhosis were administered interferon-based regimens at our hospital between August 2008 and December 2013. Thirty-four achieved sustained virological response and were enrolled in the study...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28727946/confounding-by-single-nucleotide-polymorphism-rs117648444-p70s-affects-the-association-of-interferon-lambda-locus-variants-with-response-to-interferon-%C3%AE-ribavirin-therapy-in-patients-with-chronic-genotype-3-hepatitis-c-virus-infection
#9
Anand Bhushan, Sumona Ghosh, Samsiddhi Bhattacharjee, Sreedhar Chinnaswamy
Genome-wide association studies discovered interferon lambda (IFNL or IFN-λ) locus on chromosome 19 to be involved in clearance of chronic hepatitis C virus (HCV) infection in patients following interferon-α-ribavirin (IFN-RBV) therapy. Subsequent studies established a dinucleotide polymorphism rs368234815, as the prime causal variant behind this association. The ΔG allele of this variant gives rise to a new IFNL gene, IFNL4, coding for IFN-λ4 whose activity paradoxically associates with lesser viral clearance rates...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28696822/the-balance-of-tissue-inhibitor-of-metalloproteinase-1-and-matrix-metalloproteinase-9-in-the-autoimmune-inner-ear-disease-patients
#10
Logan Eisner, Andrea Vambutas, Shresh Pathak
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the control or perpetuation of inflammation in corticosteroid-responsive (RES) and corticosteroid-resistant (NR) autoimmune inner ear disease (AIED) patients. In the present study, we observed that plasma from AIED patients exhibited greater levels of TIMP-1 values compared with normal healthy controls...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28609212/correlation-of-serum-soluble-fibrinogen-like-protein-2-with-soluble-fas-ligand-and-interferon-gamma-in-egyptian-hepatitis-c-virus-infected-patients-and-hepatocellular-carcinoma-patients
#11
Mohamed El-Mesery, Mohammed El-Mowafy, Abdelaziz Elgaml, Laila F Youssef, Sally Y Abed
Infection with hepatitis C virus (HCV) remains one of the serious human diseases worldwide, especially in Egypt, which can lead to cirrhosis or hepatocellular carcinoma (HCC). However, the exact molecular mechanism of HCC progress in HCV-infected patients remains unclear. Soluble fibrinogen-like protein 2 (sFGL2) is a modulator of the immune response that is secreted by T cells and inhibits maturation of dendritic cells and T cell proliferation. In the current study, serum sFGL2 levels were analyzed by enzyme-linked immunosorbent assay (ELISA) technique in 30 chronic HCV-infected patients (HCV group), 30 chronic HCV-infected patients with HCC (HCC group), and 12 healthy individuals (control group)...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28514196/interactions-between-ns1-of-influenza-a-viruses-and-interferon-%C3%AE-%C3%AE-determinants-for-vaccine-development
#12
Ben X Wang, Eleanor N Fish
Influenza A viruses (IAVs) cause mild to severe infections in humans with considerable socioeconomic and global health consequences. The host interferon (IFN)-α/β response, critical as the first line of defense against foreign pathogens, is induced upon detection of IAV genomic RNA in infected cells by host innate pattern recognition receptors. IFN-α/β production and subsequent activation of cell signaling result in the expression of antiviral IFN-stimulated genes whose products target various stages of the IAV life cycle to inhibit viral replication and the spread of infection and establish an antiviral state...
August 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28570146/recombinant-c1-esterase-inhibitor-reduces-cytokine-storm-in-an-ex-vivo-whole-blood-model
#13
Vladimir A Bobkov, Roman V Tikhonov, Alexander M Shuster, Dmitry A Poteryaev, Veronika N Bade
C1 esterase inhibitor (C1INH) is an abundant component of blood plasma (the average concentration is 250 mg/L); it is known to be involved in several biological processes, for instance, in the regulation of the coagulation system, adhesion of leukocytes on endothelial cells, and in the regulation of complement and kallikrein cascades. Lately, the role of C1INH in immunomodulation has gained considerable attention. We used an ex vivo whole blood model to examine the influence of C1INH and its mutated variants on the inflammatory cytokines interleukin (IL)-6, tumor necrosis factor-α (TNFα), and IL-1β...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28472595/vascular-endothelial-growth-factor-expression-in-hepatitis-c-virus-induced-liver-fibrosis-a-potential-biomarker
#14
Ghada M Salum, Noha G Bader El Din, Marwa K Ibrahim, Mohamed A Anany, Reham M Dawood, Ahmed Khairy, Mostafa K El Awady
The major complication of hepatitis C virus (HCV) infection is the induction of hepatic fibrosis. In this study, we investigated the correlation between the expression level of vascular endothelial growth factor (VEGFA) at mRNA and protein levels and the progression of HCV-related liver fibrosis. One hundred twenty subjects were selected for this study: 15 controls and 105 chronic HCV patients with different fibrosis grades (44 F0-F1 and 61 F2-F4). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to measure VEGFA mRNA in peripheral blood mononuclear cells, while enzyme-linked immunosorbent assay (ELISA) was used to measure the secreted VEGFA protein in serum...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28453369/inhibition-of-inflammatory-response-by-crocin-attenuates-hemorrhagic-shock-induced-organ-damages-in-rats
#15
Long Yang, Xiujuan Dong
Hemorrhagic shock (HS) is associated with an excessive activation of inflammation, contributing to multiple organ failure in numerous medical or surgical conditions. To explore the therapeutic potential of crocin, a natural compound with anti-inflammatory properties, we administered crocin to rats during resuscitation following HS induced by withdrawing blood. Compared with control animals which were sham-treated, HS-operated rats showed organ damages as manifested by enhanced markers of multiple organ dysfunctions...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28418769/persistency-of-neutralizing-anti-interferon-%C3%AE-antibodies-in-patients-with-multiple-sclerosis-treated-with-subcutaneous-interferon-%C3%AE-depends-on-antibody-titers-igg-subclasses-and-affinity-maturation
#16
Irena Dujmovic, Harald Hegen, Pedro Paz, Ed Croze, Florian Deisenhammer
Neutralizing antibodies may affect interferon (IFN)-β treatment efficacy, but mechanisms of neutralizing anti-drug antibody (ADA) evolution are not fully elucidated. We investigated the relationship between ADA titers, IgG subclass profile, and binding affinity with the development and persistency of neutralizing ADA in relapsing-remitting multiple sclerosis (MS) patients treated with subcutaneous IFN-β. A total of 94 patients, who had blood sampling at months 6, 12, 24, and 36 during IFN-β therapy, were included into this retrospective study and stratified to the following: non-neutralizing, transient, and persistent neutralizing ADA status...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28414566/the-changed-proportion-of-cd45ra-cd45ro-t-cells-in-chronic-hepatitis-c-patients-during-pegylated-interferon-%C3%AE-with-ribavirin-therapy
#17
Jung-Lung Hsiao, Wang-Sheng Ko, Chia-Ju Shih, Ya-Ling Chiou
Infection with the hepatitis C virus (HCV) may progress toward chronic hepatitis, liver cirrhosis, and liver cancer. A therapy for patients with chronic HCV infection is the combination of pegylated interferon-α with ribavirin, which increases the rate of sustained virological response (SVR) to 56%. However, a practical biomarker to predict SVR is lacking. T cells expressing the CD45RA isoform are considered naive, and antigenic stimulation converts them to CD45RO(+). CD45RO(+) T cells exhibit immediate response and high lymphokine production, leading to the maintenance and upregulation of immune reactions...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28402153/maternal-fetal-transmission-of-zika-virus-routes-and-signals-for-infection
#18
Bin Cao, Michael S Diamond, Indira U Mysorekar
The emerging mosquito-borne virus, Zika virus (ZIKV), has been causally associated with adverse pregnancy and neonatal outcomes, including miscarriage, microcephaly, serious brain abnormalities, and other birth defects indicative of a congenital ZIKV syndrome. In this review, we highlight work from human and animal studies on routes of infection in pregnancy that lead to adverse fetal and neonatal outcomes. A number of innate and adaptive immune mechanisms and signaling molecules that may have key roles in ZIKV infection pathogenesis are discussed along with putative viral entry pathways...
July 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28467275/beyond-isglylation-functions-of-free-intracellular-and-extracellular-isg15
#19
Paula Fernandes Dos Santos, Daniel Santos Mansur
ISG15 is a ubiquitin-like type I IFN-stimulated protein of 15 kDa and is one of the most prominently expressed proteins in viral infections. ISG15 is widely known to be involved in a process called ISGylation, where it binds to over 150 targets from a variety of classes of proteins including central immune signaling pathways such as those mediated by NFκB, JNK, and IRF-3. However, ISG15 also exists in a free form that can act intra- or extracellularly. In vitro and in vivo evidences suggest that free ISG15 play different roles in several cellular processes, from cancer and defense against viral infections to activation of immune cells such as lymphocytes, monocytes, and NK cells...
June 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28440692/both-hepatitis-c-virus-specific-t-cell-responses-and-il28b-rs12979860-single-nucleotide-polymorphism-genotype-influence-antihepatitis-c-virus-treatment-outcome-in-patients-with-chronic-hepatitis-c
#20
José M Benito, Javier García-Samaniego, Marcial García, Antonio Madejón, Luz Martín-Carbonero, Alfonso Cabello, Beatriz Álvarez, Miguel Górgolas, Norma Rallón
Despite new treatments for hepatitis C virus (HCV) infection, IFNα-based regimens still have clinical relevance in special populations of patients and remain the only therapeutic option for many patients. We sought to elucidate the interplay between two relevant factors (IL28B polymorphism and T cell immune responses) involved in the outcome of this therapy in HCV-infected patients. We evaluated 38 patients infected with HCV genotype 1-17 coinfected with HIV-who were undergoing a full course of pegIFNα/RBV therapy...
June 2017: Journal of Interferon & Cytokine Research
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