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Journal of Interferon & Cytokine Research

Paulina Żelechowska, Elżbieta Kozłowska, Joanna Pastwińska, Justyna Agier, Ewa Brzezińska-Błaszczyk
The innate immune response is defined as an immensely complex and sophisticated process aimed at defending the organism against any disturbance in the body homeostasis, including invading pathogens. It requires a close cooperation of a vast amount of different cell types, recognized as inflammatory migrating cells, as well as stationary cells that form tissues. Moreover, innate immune mechanisms require an efficient functioning of various humoral components that exert a significant impact on physiological and pathological processes...
November 15, 2018: Journal of Interferon & Cytokine Research
Luhong Han, Lin Li, Nan Wang, Youyi Xiong, Yin Li, Yuanting Gu
This research explores the role of epidermal growth factor receptor (EGFR) in the clinical symptoms and metastasis of patients with invasive breast cancer (IBC). A total of 189 patients with IBC were selected in this research. Immunohistochemical staining and Western blot were performed to detect EGFR in IBC and paratumor breast tissues. The results of statistical analysis showed that the positive expression of EGFR in IBC (140/189 = 74.07%) was significantly higher than that of paratumor breast tissues (23/189 = 12...
November 15, 2018: Journal of Interferon & Cytokine Research
Maroua Miliani, Mouna Nouar, Océane Paris, Gérard Lefranc, Franck Mennechet, Mourad Aribi
Antitumor activity of classically activated macrophage (Mϕ) may be impaired within the tumors, spleen, and bone marrow. Thus, it is possible to boost its antitumor activity after its pulsing with necrotic tumor cell lysates combined with an adjuvant. We set out to determine the potential adjuvant effects of thymoquinone (TQ; 2-isopropyl-5-methyl-1,4-benzoquinone, C10 H12 O2 ) on both functional activities of classically activated Mϕs, pulsed or not with necrotic Jurkat T cell line lysates (NecrJCL), and the balance of antitumor cytokines (ATCs) versus immunosuppressive cytokines (ISCs) during crosstalk with autologous human CD4+ T cells...
November 13, 2018: Journal of Interferon & Cytokine Research
M Raza Zaidi
Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor immune responses in the elimination stage of the immunoediting paradigm. However, mounting evidence suggests that IFNG may also have important and significant protumor roles to play in the equilibrium and escape phases through its regulatory effects on immunoevasive functions that promote tumorigenesis. These seemingly contradictory effects of IFNG undoubtedly play profound roles in not only the activation of inflammatory response to cancer but also in the determination of its outcome...
November 9, 2018: Journal of Interferon & Cytokine Research
Tao-Cheng Wu, Chih-Yao Chiang, Jenq-Shyong Chan, Chiu-Yang Lee, Hsin-Bang Leu, Po-Hsun Huang, Jia-Shiong Chen, Shing-Jong Lin, Jaw-Wen Chen
Rheumatoid arthritis (RA) with diabetes increases the risk of cardiovascular diseases. Interleukin-6 (IL-6) promotes the disease activity of RA and insulin resistance. This study aimed to evaluate the potential effects and molecular mechanisms of IL-6 blocker, tocilizumab, in atherosclerosis with diabetes. Human aortic smooth muscle cells (HASMCs) cultured under hyperglycemic conditions were evaluated for migration, expression of adhesion molecules, and matrix metalloproteinases before and after treatment with tocilizumab...
October 31, 2018: Journal of Interferon & Cytokine Research
Dina Sabry, Omayma O Abdelaleem, Enas M Hefzy, Amal A Ibrahim, Tarek I Ahmed, Essam A Hassan, Nehal D Abdel-Hameed, Mahmoud A F Khalil
Helicobacter pylori is a ubiquitous Gram-negative bacterium, that is responsible for gastric mucosal inflammation. It is the most common risk factor for gastric cancer (GC). The current study aimed to investigate the association between interleukin-11 (IL-11) and leukemia inhibitory factor (LIF) levels among H. pylori-infected Egyptian patients with gastritis and GC. One hundred forty-seven patients with gastric lesions were endoscopically biopsied and assessed using rapid urease test and immunohistochemistry...
October 31, 2018: Journal of Interferon & Cytokine Research
Jing-Wen Wang, Jing-Wei Wang, Jun Zhang, Chen-Si Wu, Yu Fang, Wei-Wei Su, Yu-Chen Fan, Kai Wang
Type I interferons (IFNs) play an antiviral effect by binding to type I interferon receptor (IFNAR). Oxidative stress might induce the gene promoter methylation. The purpose of our study was to evaluate the potential relationship between the methylation of IFNAR promoter and the status of oxidative stress in chronic hepatitis B (CHB). The methylation level of the IFNAR promoter in patients with CHB and healthy controls (HCs) was determined by methylation-specific polymerase chain reaction (MS-PCR). The quantitative real-time PCR (RT-qPCR) was used to evaluate the IFNAR mRNA status in peripheral blood mononuclear cells from CHB and HCs...
October 31, 2018: Journal of Interferon & Cytokine Research
Sophie Jacobs, Fanny Wavreil, Bert Schepens, Hans Henrik Gad, Rune Hartmann, Joana Rocha-Pereira, Johan Neyts, Xavier Saelens, Thomas Michiels
The type III interferon (IFN-λ) family includes 4 IFN-λ subtypes in man. In the mouse, only the genes coding for IFN-λ2 and -λ3 are present. Unlike mouse and human type I IFNs (IFN-α/β), which exhibit strong species specificity, type III IFNs were reported to act in a cross-specific manner. We reexamined the cross-specificity and observed that mouse and human IFN-λ exhibit some species specificity, although much less than type I IFNs. Mouse IFN-λ3 displayed clear species specificity, being 25-fold less active in human cells than the closely related mouse IFN-λ2...
October 18, 2018: Journal of Interferon & Cytokine Research
Yang Fang Wu, Dong Dong Zhang, Si Yan Liu, Huang Huang Luo, Guang Mei Jiang, Yao Xu, Yue Wu, Jing Jing Wang, Fei Fei Liu, Sama Samadli, Wei Wei, Bo Hu, Peng Hu
C-type natriuretic peptide (CNP) is believed to be produced locally in the kidneys and possess several renoprotective properties. In contrast, fibroblast growth factor (FGF) -23 elevates in the early stage of chronic kidney disease and predicts its outcomes. Currently, several studies have demonstrated that CNP and FGF-23 act through a close pathway, and moreover, FGF-23/mitogen-activated protein kinase (MAPK) can be obviously suppressed by CNP. In the present study, human mesangial cells (MCs) were incubated in serum-containing medium in the absence or presence of CNP (0, 10 and 100 pM) for 24, 48 and 72 h, respectively...
October 18, 2018: Journal of Interferon & Cytokine Research
Lucía Angélica Méndez-García, Karen Elizabeth Nava-Castro, Tania de Lourdes Ochoa-Mercado, Margarita Isabel Palacios-Arreola, Rocío Alejandra Ruiz-Manzano, Mariana Segovia-Mendoza, Helena Solleiro-Villavicencio, Cinthia Cázarez-Martínez, Jorge Morales-Montor
In breast cancer, an uncontrolled cell proliferation leads to tumor formation and development of a multifactorial disease. Metastasis is a complex process that involves tumor spread to distant parts of the body from its original site. Metastatic dissemination represents the main physiopathology of cancer. Inter- and intracellular communication in all systems in vertebrates is mediated by cytokines, which are highly inducible, secretory proteins, produced not only by immune system cells, but also by endocrine and nervous system cells...
October 13, 2018: Journal of Interferon & Cytokine Research
Jaewoo Hong, Soohyun Kim, P Charles Lin
Interleukin-33 (IL-33) is one of the members of the IL-1 family of cytokines and a ligand of ST2 and IL-1 receptor accessory protein (IL-1RAcP) that is known to affect Th2 inflammatory response with partial effects on Th1 responses. This cytokine is released by epithelial and smooth muscle cells of the airway system during their injury by several environmental stimuli, such as allergens, viruses, helminths, and pollutants. IL-33 is an alarmin that acts as an endogenous danger signal, and it has been known to affect various types of cells, such as mast cells, basophils, eosinophils, T cells, and specific subsets of innate lymphoid cells (ILCs)...
September 25, 2018: Journal of Interferon & Cytokine Research
Wenjing Liu, Chao Chang, Haiying Hu, Hua Yang
Accumulating evidence has shown that atherosclerosis is an inflammatory disease. The pathogenesis of atherosclerosis has been confirmed to involve an imbalance in anti-inflammatory/proinflammatory processes. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of the IL-23p19 and IL-12p40 subunits of the IL-12 family. Experiments show that IL-23 induces CD4+ T cells to differentiate into T helper type 17 cells, promotes the expression of interferon-γ, and inhibits the production of Foxp3. Therefore, IL-23 induces and exacerbates effector T lymphocyte/regulatory T cell imbalance...
October 2018: Journal of Interferon & Cytokine Research
Leila Mahdavinejad, Mahdi Alahgholi-Hajibehzad, Mohammad Mahdi Eftekharian, Zohre Zaerieghane, Iraj Salehi, Mehrdad Hajilooi, Hanie Mahaki, Alireza Zamani
The study aimed to determine effect of extremely low frequency (50 Hz) electromagnetic fields (ELF-EMFs) exposure on serum levels of interleukin-17 (IL-17) and transforming growth factor-β (TGF-β) as signature cytokines of Th17 and regulatory T (Treg) cells, respectively. Retinoid-related orphan receptor γT and transcription factor forkhead box P3 (Foxp3) expression levels as lineage defining of Th17 and Treg cells were also assessed in the spleen and thymus. Eighty male rats were separated into 4 exposed groups (1, 100, 500, and 2,000 μT magnetic flux intensities) and a control...
October 2018: Journal of Interferon & Cytokine Research
Anna C Pfalzer, Jimmy W Crott, Gar Yee Koh, Donald E Smith, Paloma E Garcia, Joel B Mason
Obesity is a prominent risk factor for colorectal cancer (CRC). One mechanism by which obesity promotes the development of CRC is by generating a chronic, low-grade state of colonic inflammation. Interleukin-1β (IL-1β), a proinflammatory cytokine often elevated in obesity, is known to activate several procarcinogenic signaling pathways that are implicated in colonic carcinogenesis. We therefore sought to define the role of IL-1β in mediating some of the early biochemical and molecular events leading up to obesity-promoted CRC...
October 2018: Journal of Interferon & Cytokine Research
Jovani Catalan-Dibene, Laura L McIntyre, Albert Zlotnik
Cytokines are important molecules that regulate the ontogeny and function of the immune system. They are small secreted proteins usually produced upon activation of cells of the immune system, including lymphocytes and myeloid cells. Many cytokines have been described, and several have been recognized as pivotal players in immune responses and in human disease. In fact, several anticytokine antibodies have proven effective therapeutics, especially in various autoimmune diseases. In the last 15 years, new cytokines have been described, and many remain poorly understood...
October 2018: Journal of Interferon & Cytokine Research
Meiling Han, Yuxuan Li, Siyan Liu, Shenyi Jiang, Lin Yuan, Liping Xia, Hui Shen, Jing Lu
Interleukin-35 (IL-35) is a critical anti-inflammatory cytokine in autoimmune disease. In the current study, we aimed to investigate the serum IL-35 levels and its clinical association in patients with primary Sjögren's syndrome (pSS) and to investigate whether or not IL-35 participates in the pathogenesis of pSS. One hundred seventy-six pSS patients and 60 healthy controls (HCs) were recruited. Disease activity was assessed according to EULAR SS disease activity index. Serum IL-35 levels were quantified by enzyme-linked immunosorbent assay...
October 2018: Journal of Interferon & Cytokine Research
Li-Hua Peng, Xiao-Qun Qin, Ru-Rong Tan, Chi Liu, Hui-Jun Liu, Xiangping Qu
In this study we tried to explore whether calcitonin gene-related peptide (CGRP) regulates the potential antigen uptaking ability of human bronchial epithelial cells (HBECs) and promoting the differentiation of Th1/Th2. We found that CGRP increased the uptake of fluorescein isothiocyanate labeled ovalbumin (FITC-OVA) by HBECs using fluorescence microscopy and flow cytometry analysis. MTT assay showed that T cells proliferated in a dose-dependent manner in the presence of OVA-pretreated HBECs and CGRP inhibited the proliferation of T cells...
October 2018: Journal of Interferon & Cytokine Research
Shasha Liu, Nanfang Li, Qing Zhu, Bin Zhu, Ting Wu, Guoliang Wang, Shanshan Liu, Qin Luo
Monocyte chemotactic protein 1 (MCP-1) plays a significant role in inflammation pathways by affecting monocyte/macrophage migration, the number of monocytes and T lymphocytes, and osmosis. Inflammation is closely linked to various types of systematic vasculitis. Here we characterized serum MCP-1 levels in systemic vasculitis patients. This cross-sectional study included serum samples collected from 43 patients with systemic vasculitis and 43 healthy controls (HCs). Serum MCP-1 levels in the samples were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits...
September 2018: Journal of Interferon & Cytokine Research
Yanying Zhao, Haipeng Liu, Libo Xu, Baofeng Guo, Dhananjaya V Kalvakolanu, Xichun Liu, Jiadi Hu, Duoduo Zhang, Yuanjie Sun, Ling Zhang, Deqi Xu, Xuejian Zhao
Melanoma is one of the most lethal skin malignancies in the world. Interferons (IFNs) have been also demonstrated in response to tumor cell and IFNs such as IFN-α have been used for melanoma treatment. The long chain double-stranded RNA (dsRNA) (from a variety of nonviral sources) is a potent activator of the IFN system and an inducer of cell apoptosis. Panaxadiolsaponins (PDS) is a major Panax ginseng-derived active component with known antitumor activity and immune modulation. Here, we investigated a hypothesis that the combination of PDS and total natural dsRNA (as opposed to the synthetic dsRNA) will suppress tumor growth better than the individual agents...
September 2018: Journal of Interferon & Cytokine Research
Rochelle C Joslyn, Adriana Forero, Richard Green, Stephen E Parker, Ram Savan
Long noncoding RNAs (lncRNAs) exhibit highly lineage-specific expression and act through diverse mechanisms to exert control over a wide range of cellular processes. lncRNAs can function as potent modulators of innate immune responses through control of transcriptional and posttranscriptional regulation of mRNA expression and processing. Recent studies have demonstrated that lncRNAs participate in the regulation of antiviral responses and autoimmune disease. Despite their emerging role as immune mediators, the mechanisms that govern lncRNA expression and function have only begun to be characterized...
September 2018: Journal of Interferon & Cytokine Research
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