Bianca M Nastri, Annalisa Chianese, Rosa Giugliano, Laura Di Clemente, Carla Capasso, Alessandra Monti, Nunzianna Doti, Valentina Iovane, Serena Montagnaro, Ugo Pagnini, Giuseppe Iovane, Carla Zannella, Anna De Filippis, Massimiliano Galdiero
In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin-1 (oreoch-1), a fish-derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV-1), and bovine herpesvirus 1 (BoHV-1)...
March 12, 2024: Journal of Peptide Science