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Journal of Peptide Science: An Official Publication of the European Peptide Society

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https://www.readbyqxmd.com/read/30393975/piezoelectric-property-of-bundled-peptide-nanotubes-stapled-by-bis-cyclic-%C3%AE-peptide
#1
Yuki Tabata, Kazushi Takagaki, Hirotaka Uji, Shunsaku Kimura
Cyclic tetra-β-peptides (CP4s) and a bis-CP4 were synthesized to prepare peptide nanotubes (PNTs) by molecular stacking of cyclic peptides. The addition of bis-CP4 to the PNT preparation afforded PNT bundles increasing the direct and converse piezoelectiric coefficients, which is ascribable to bis-CP4 stapling PNTs into the parallel alignment of PNT dipoles.
November 4, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30393903/chemical-synthesis-of-a-two-domain-scorpion-toxin-lait2-and-its-single-domain-analogs-to-elucidate-structural-factors-important-for-insecticidal-and-antimicrobial-activities
#2
Hironori Juichi, Ryo Ando, Takafumi Ishido, Masahiro Miyashita, Yoshiaki Nakagawa, Hisashi Miyagawa
Scorpion venom contains various bioactive peptides. Among them, peptides having two different structural domains constitute a toxin family known as β-KTx or scorpine-like peptides. These peptides consist of an α-helical structure in the N-terminal region and a cysteine-stabilized structure in the C-terminal region. This unique structure of β-KTx peptides contributes to their diverse biological functions, but the importance of each domain for their activities is not fully understood. LaIT2 is a β-KTx peptide isolated from the venom of the scorpion Liocheles australasiae, which shows both insecticidal and antimicrobial activities...
November 4, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30358026/antibacterial-effects-of-gold-nanoparticles-functionalized-with-the-extracted-peptide-from-vespa-orientalis-wasp-venom
#3
Jafar Jalaei, Somayeh Layeghi-Ghalehsoukhteh, Arsalan Hosseini, Mehdi Fazeli
The development of novel antimicrobial strategies is necessary because of the escalation of multidrug-resistant pathogens. Recently, antimicrobial peptides and their combination with nanoparticles were regarded as a promising tool to target drug-resistant pathogens. Herein, we evaluated antimicrobial efficacy of a peptide extracted from Vespa orientalis wasp venom and also its conjugation with gold nanoparticles. Nanoparticle conjugation measurement was done by evaluating the absorbance changes of the surface plasmon resonance band of gold nanoparticles at 555 nm...
October 25, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30346100/chemical-synthesis-of-the-crustacean-insulin-like-peptide-with-four-disulfide-bonds
#4
Hidekazu Katayama, Takafumi Mukainakano, Junya Kogure, Tsuyoshi Ohira
Among the insulin-family peptides, two additional cysteine residues other than six conserved cysteines are sometimes found in invertebrate insulin-like peptides (ILPs), although the synthetic method for such four disulfide ILPs has not yet been well established. In this study, we synthesized a crustacean insulin-like androgenic gland factor with four disulfides by the regioselective disulfide bond formation reactions using four orthogonal Cys-protecting groups. Its disulfide isomer could be also synthesized by the same method, indicating that the synthetic strategy developed in this study might be useful for the synthesis of other four disulfide ILPs...
October 22, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30346065/an-explorative-study-towards-the-chemical-synthesis-of-the-immunoglobulin-g1-fc-ch3-domain
#5
Luigi Grassi, Cornelia Roschger, Vesna Stanojlović, Chiara Cabrele
Monoclonal antibodies, fusion proteins including the immunoglobulin fragment c (Ig Fc) CH2-CH3 domains, and engineered antibodies are prominent representatives of an important class of drugs and drug candidates, which are referred to as biotherapeutics or biopharmaceuticals. These recombinant proteins are highly heterogeneous due to their glycosylation pattern. In addition, enzyme-independent reactions, like deamidation, dehydration, and oxidation of sensitive side chains, may contribute to their heterogeneity in a minor amount...
October 22, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30325562/development-of-lipopolyplexes-for-gene-delivery-a-comparison-of-the-effects-of-differing-modes-of-targeting-peptide-display-on-the-structure-and-transfection-activities-of-lipopolyplexes
#6
Robin Bofinger, May Zaw-Thin, Nicholas J Mitchell, P Stephen Patrick, Cassandra Stowe, Ana Gomez-Ramirez, Helen C Hailes, Tammy L Kalber, Alethea B Tabor
The design, synthesis and formulation of non-viral gene delivery vectors is an area of renewed research interest. Amongst the most efficient non-viral gene delivery systems are lipopolyplexes, in which cationic peptides are co-formulated with plasmid DNA and lipids. One advantage of lipopolyplex vectors is that they have the potential to be targeted to specific cell types by attaching peptide targeting ligands on the surface, thus increasing both the transfection efficiency and selectivity for disease targets such as cancer cells...
October 16, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30353614/reduction-of-cysteine-s-protecting-groups-by-triisopropylsilane
#7
Emma J Ste Marie, Robert J Hondal
Triisopropylsilane (TIS), a hindered hydrosilane, has long been utilized as a cation scavenger for the removal of amino acid protecting groups during peptide synthesis. However, its ability to actively remove S-protecting groups by serving as a reductant has largely been mischaracterized by the peptide community. Here, we provide strong evidence that TIS can act as a reducing agent to facilitate the removal of acetamidomethyl (Acm), 4-methoxybenzyl (Mob), and tert-butyl (But ) protecting groups from cysteine (Cys) residues in the presence of trifluoroacetic acid (TFA) at 37 °C...
November 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30325566/properties-of-novel-surfactin-derived-biosurfactants-obtained-through-solid-phase-synthesis
#8
Leonardo Vazquez, Andre Teixeira da Silva Ferreira, Fernanda Sampaio Cavalcante, Israel José P Garcia, Katia Regina Netto Dos Santos, Leandro Augusto de Oliveira Barbosa, Marcius da Silva Almeida, Julio Alberto Mignaco, Carlos Frederico Leite Fontes
Eight molecules, four peptides (SPs) and four lipopeptides (LPs) derived by rational design from surfactin, a well-known secreted biosurfactant from Bacillus subtilis, were produced employing Fmoc-based solid-phase synthesis. These new peptides were tested to evaluate their potential biosurfactant and biological activities, aiming at possible applications in industrial, biological, pharmaceutical, and medical use. Five molecules (SP1, SP2, SP4, LP5, and LP8) presented potential for medical uses, mainly due to their drug delivery properties as suggested by their synergistic activity with the antibiotic vancomycin against Staphylococcus aureus...
November 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30288870/characterization-of-a-peptide-containing-the-major-heparin-binding-domain-of-human-hepatic-lipase
#9
Breanne M Coady, Jenika D Marshall, Luke E Hattie, Alexander M Brannan, Madeline N Fitzpatrick, Kala E Hickey, Stefan Wallin, Valerie Booth, Robert J Brown
Human hepatic lipase (hHL) is a cell surface associated enzyme that hydrolyzes triacylglycerols and phospholipids within circulating lipoproteins. We hypothesized that an amino acid sequence mimicking the major heparin binding domain (HBD) of hHL will displace hHL from cell surfaces. To test this hypothesis, we generated a recombinant protein of thioredoxin linked with a cleavable, tagged sequence containing amino acids 442 to 476 of the mature hHL sequence, which contains the major HBD of hHL. The recombinant protein associated with heparin-sepharose, and its peak elution from heparin-sepharose occurred in the presence of 0...
November 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30288867/recombinant-human-follicle-stimulating-hormone-purification-by-a-short-peptide-affinity-chromatography
#10
Juan M Gurevich Messina, Silvana L Giudicessi, María C Martínez Ceron, Nicolás Urtasun, Guillermina Forno, Laura Mauro, Osvaldo Cascone, Silvia A Camperi
Peptide KVPLITVSKAK was selected to design a synthetic ligand for affinity chromatography purification of recombinant human follicle stimulating hormone (rhFSH), based on the interaction of the hormone with the exoloop 3 of its receptor. The peptide was acetylated to improve its stability to degradation by exopeptidases. A cysteine was incorporated at the C-termini to facilitate its immobilization to the chromatographic activated SulfoLink agarose resin. A sample of crude rhFSH was loaded to the affinity column, using 20 mM sodium phosphate, 0...
November 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30251388/effect-of-cellular-polyanion-mimetics-on-tau-peptide-aggregation
#11
Tania Ismail, Mathumai Kanapathipillai
Tau protein aggregation is believed to be one of the key drivers of Alzheimer's disease. The two hexapeptide amino acid sequences 306 VQIVYK311 and 275 VQIINK280 of the tau protein are responsible for aggregation, and subsequent functional loss leading to Alzheimer's progression. Hence, it is important to understand the factors that promote the self-aggregation of this tau peptide fragments. Cellular microenvironmental polyanions are known to play a major role in tau protein aggregation and loss of function...
November 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30270484/znf185-derived-peptide-induces-fertility-suppression-in-mice
#12
Shutong Fan, Yuhan Zhao, Zhiwei Pan, Zhiqin Gao, Zumu Liang, Zhifang Pan, Weiguo Feng
Zinc finger protein 185 (ZNF185) belongs to the ZNF family and is involved in male reproduction. However, it is unclear whether ZNF185 may be a target candidate for contraceptive vaccines. In this study, antigenic peptides derived from ZNF185 were prepared, and their immune contraceptive effects were investigated using mice. Results from enzyme-linked immunosorbent assay (ELISAs) showed that peptide immunization induced an antibody titre increase that reached a peak in week 12. Peptide-3 and peptide-4 were then chosen for subsequent experiments...
October 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30221432/ascidiacyclamides-containing-oxazoline-and-thiazole-motifs-assume-square-conformations-and-show-high-cytotoxicity
#13
Akiko Asano, Takeshi Yamada, Taizo Taniguchi, Masahiro Sasaki, Kenji Yoza, Mitsunobu Doi
Four cyclic octapeptides were designed from ascidiacyclamide [cyclo(-Ile-Oxz-D-Val- Thz-)2 ] (ASC, 1) to investigate the effects of oxazoline (Oxz) and thiazole (Thz) rings on the structures and cytotoxicities of the peptides. cyclo(-Ile-Thz-D-Val-Oxz-)2 (2) had the same number of Oxz and Thz rings as ASC, but the ring positions were switched. cyclo(-Ile-Oxz-D-Val-Thz-Ile-Thz-D-Val-Thz-) (3) and cyclo(-Ile-Thz-D-Val-Oxz-Ile-Thz-D-Val-Thz-) (4) contained one Oxz and three Thz rings within the molecule. All Oxz rings were substituted with Thz in cyclo(-Ile-Thz-D-Val-Thz-)2 (5)...
October 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30168238/a-stable-meta-carborane-enables-the-generation-of-boron-rich-peptide-agonists-targeting-the-ghrelin-receptor
#14
Dennis J Worm, Sylvia Els-Heindl, Martin Kellert, Robert Kuhnert, Stefan Saretz, Johannes Koebberling, Bernd Riedl, Evamarie Hey-Hawkins, Annette G Beck-Sickinger
Boron neutron capture therapy (BNCT) is a binary cancer therapy, which combines the biochemical targeting of a boron-containing drug with the regional localization of radiation treatment. Although the concept of BNCT has been known for decades, the selective delivery of boron into tumor cells remains challenging. G protein-coupled receptors that are overexpressed on cancer cells in combination with peptidic ligands can be potentially used as shuttle system for a tumor-directed boron uptake. In this study, we present the generation of short, boron-rich peptide conjugates that target the ghrelin receptor...
October 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30232828/35-th-european-peptide-symposium-26-th-31-st-august-2018-dublin-city-university-ireland
#15
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30112781/an-amphipathic-cyclic-tetrapeptide-scaffold-containing-halogenated-%C3%AE-2-2-amino-acids-with-activity-against-multiresistant-bacteria
#16
Marianne H Paulsen, Eskil André Karlsen, Dominik Ausbacher, Trude Anderssen, Annette Bayer, Philipp Ochtrop, Christian Hedberg, Tor Haug, Johanna U Ericson Sollid, Morten B Strøm
The present study describes the synthesis and biological studies of a small series of head-to-tail cyclic tetrapeptides of the general structure c(Lys-β2,2 -Xaa-Lys) containing one lipophilic β2,2 -amino acid and Lys, Gly, Ala, or Phe as the Xaa residue in the sequence. The peptides were investigated for antimicrobial activity against gram-positive and gram-negative reference strains and 30 multiresistant clinical isolates including strains with extended spectrum β-lactamase-carbapenemase (ESBL-CARBA) production...
August 15, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30084214/the-effect-of-conjugation-on-antitumor-activity-of-vindoline-derivatives-with-octaarginine-a-cell-penetrating-peptide
#17
Zoltán Bánóczi, András Keglevich, Ildikó Szabó, Ivan Ranđelović, Zita Hegedüs, Fruzsina L Regenbach, Péter Keglevich, Zsófia Lengyel, Álmos Gorka-Kereskényi, Zsófia Dubrovay, Viktor Háda, Áron Szigetvári, Csaba Szántay, László Hazai, József Tóvári, Ferenc Hudecz
Some Vinca alkaloids (eg, vinblastine, vincristine) have been widely used as antitumor drugs for a long time. Unfortunately, vindoline, a main alkaloid component of Catharanthus roseus (L.) G. Don, itself, has no antitumor activity. In our novel research program, we have prepared and identified new vindoline derivatives with moderate cytostatic activity. Here, we describe the effect of conjugation of vindoline derivative with oligoarginine (tetra-, hexa-, or octapeptides) cell-penetrating peptides on the cytostatic activity in vitro and in vivo...
August 6, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30062707/osmolytes-modulate-polyglutamine-aggregation-in-a-sequence-dependent-manner
#18
Itika Saha, Virender Singh, Gunasekhar Burra, Ashwani Kumar Thakur
Osmolytes stabilize protein structure and suppress protein aggregation. The mechanism of how osmolytes impact polyglutamine (polyQ) aggregation implicated in Huntington's disease was studied. By using a reverse-phase chromatography assay, we show that methylamines-trimethylamine N-oxide and betaine are generic in enhancing polyQ aggregation, while a disaccharide trehalose and an amino acid citrulline moderately retard polyQ aggregation in a sequence specific manner. Despite the altered kinetics, the fundamental nucleation mechanism of polyQ aggregation and the nature of end stage aggregates remains unaffected...
August 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30019359/on-the-design-and-efficacy-assessment-of-self-assembling-peptide-based-hydrogel-glycosaminoglycan-mixtures-for-potential-repair-of-early-stage-cartilage-degeneration
#19
A Barco, E Ingham, J Fisher, H Fermor, R P W Davies
Peptide-based hydrogels are of interest for their potential use in regenerative medicine. Combining these hydrogels with materials that may enhance their physical and biological properties, such as glycosaminoglycans, has the potential to extend their range of biomedical applications, for example in the repair of early cartilage degeneration. The aim of this study was to combine three self-assembling peptides (P11 -4, P11 -8, and P11 -12) with chondroitin sulphate at two molar ratios of 1:16 and 1:64 in 130 and 230 mM Na+ salt concentrations...
August 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/30009478/further-applications-of-classical-amide-coupling-reagents-microwave-assisted-esterification-on-solid-phase
#20
Risa Takayama, Shun Hayakawa, Hiroshi Hinou, Fernando Albericio, Fayna Garcia-Martin
Ester linkage (s) is a key chemical connector in organic chemistry, including natural products, peptides, and synthetic polymers. We herein describe a straightforward method for the efficient formation of ester linkage (s) on solid-phase. This method simply involves the use of amide coupling reagents under microwave irradiation. The robustness of this method relies on the use of classical solid-phase coupling reagents, heating by microwave irradiation, and a short time period, which results in high yields and the minimization of racemization...
August 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
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