journal
https://read.qxmd.com/read/38531546/bergofungin-d-a-peptaibol-template-for-the-introduction-of-chemical-modifications-synthesis-of-analogs-and-comparative-studies-of-their-structures
#1
JOURNAL ARTICLE
Sanjit Das, Khoubaib Haj Ben Salah, Emmanuel Wenger, Baptiste Legrand, Claude Didierjean, Nicolas Inguimbert
Bergofungin D is a helical peptide of the peptaibol family consisting of 14 amino acids, six of which are the helix inducer aminoisobutyric acid (Aib). In the second third of the sequence, a hydroxyproline causes a bending of the helix and a disruption of the hydrogen bond network, and Aib7 is the only amino acid in this region involved in the hydrogen bond network. Therefore, modification of this residue can serve as a probe to monitor the effect of introducing amino acid substitutions on this more fragile helical turn...
March 26, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38523558/n-terminal-modification-of-an-lah4-derived-peptide-increases-mrna-delivery-in-the-presence-of-serum
#2
JOURNAL ARTICLE
Candice Dussouillez, Morane Lointier, Mohammed-Karim Sebane, Sylvie Fournel, Burkhard Bechinger, Antoine Kichler
The recently developed mRNA-based coronavirus SARS-CoV-2 vaccines highlighted the great therapeutic potential of the mRNA technology. Although the lipid nanoparticles used for the delivery of the mRNA are very efficient, they showed, in some cases, the induction of side effects as well as the production of antibodies directed against particle components. Thus, the development of alternative delivery systems is of great interest in the pursuit of more effective mRNA treatments. In the present work, we evaluated the mRNA transfection capacities of a series of cationic histidine-rich amphipathic peptides derived from LAH4...
March 25, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38499991/supercharged-coiled-coil-protein-with-n-terminal-decahistidine-tag-boosts-sirna-complexation-and-delivery-efficiency-of-a-lipoproteoplex
#3
JOURNAL ARTICLE
Jonathan W Sun, Joseph S Thomas, Julia M Monkovic, Halle Gibson, Akash Nagapurkar, Joseph A Frezzo, Priya Katyal, Kamia Punia, Farbod Mahoudinobar, P Douglas Renfrew, Jin Kim Montclare
Short interfering RNA (siRNA) therapeutics have soared in popularity due to their highly selective and potent targeting of faulty genes, providing a non-palliative approach to address diseases. Despite their potential, effective transfection of siRNA into cells requires the assistance of an accompanying vector. Vectors constructed from non-viral materials, while offering safer and non-cytotoxic profiles, often grapple with lackluster loading and delivery efficiencies, necessitating substantial milligram quantities of expensive siRNA to confer the desired downstream effects...
March 18, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38494339/wound-microenvironment-responsive-peptide-hydrogel-with-multifunctionalities-for-accelerating-wound-healing
#4
JOURNAL ARTICLE
Weimiao Dong, Haihong Yang, Min Liu, Leixia Mei, Jun Han
The fabrication of wound microenvironment-responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self-assembly of a peptide (Pep-1) and water-soluble new methylene blue (NMB) through electrostatic interaction. The self-assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis...
March 17, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38471735/hybrid-peptide-pna-monomers-as-building-blocks-for-the-fabrication-of-supramolecular-aggregates
#5
JOURNAL ARTICLE
Luca Cimmino, Carlo Diaferia, Mariangela Rosa, Giancarlo Morelli, Elisabetta Rosa, Antonella Accardo
Advantages like biocompatibility, biodegradability and tunability allowed the exploitation of peptides and peptidomimetics as versatile therapeutic or diagnostic agents. Because of their selectivity towards transmembrane receptors or cell membranes, peptides have also been identified as suitable molecules able to deliver in vivo macromolecules, proteins or nucleic acids. However, after the identification of the homodimer diphenylalanine (FF) as an aggregative motif inside the Aβ1-42 polypeptide, short and ultrashort peptides have been studied as building blocks for the fabrication of supramolecular, ordered nanostructures for applications in biotechnological, biomedical and industrial fields...
March 12, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38471710/oreoch-1-a-broad-spectrum-virus-and-host-targeting-peptide-against-animal-infections
#6
JOURNAL ARTICLE
Bianca M Nastri, Annalisa Chianese, Rosa Giugliano, Laura Di Clemente, Carla Capasso, Alessandra Monti, Nunzianna Doti, Valentina Iovane, Serena Montagnaro, Ugo Pagnini, Giuseppe Iovane, Carla Zannella, Anna De Filippis, Massimiliano Galdiero
In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin-1 (oreoch-1), a fish-derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV-1), and bovine herpesvirus 1 (BoHV-1)...
March 12, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38447547/towards-targeted-cas9-crispr-cas-delivery-preparation-of-igg-antibody-cas9-conjugates-using-a-split-intein
#7
JOURNAL ARTICLE
Tim Pasch, Nicole Bäumer, Sebastian Bäumer, Frank Buchholz, Henning D Mootz
The CRISPR-Cas9 system has revolutionized the field of genetic engineering, but targeted cellular delivery remains a central problem. The delivery of the preformed ribonuclease-protein (RNP) complex has the advantages of fewer side effects and avoidance of potential permanent effects. We reasoned that an internalizing IgG antibody as a targeting device could address the delivery of Cas9-RNP. We opted for protein trans-splicing mediated by a split intein to facilitate posttranslational conjugation of the two large protein entities...
March 6, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38396336/isolation-and-antioxidant-activity-of-peptides-from-chinese-hairy-tofu
#8
JOURNAL ARTICLE
Li-Ping Wu, Yong-Xiang Wu, Xiang-Tao Ke, Pan Wang, Shuo Zhang, Yu-Ting Zhu, Ying Lu, Yu-Jie Shu, Shang-Yue Jiang, Chang-Jiang Li, Xiao-Qian Hu
Hairy tofu is a famous Chinese snack that is made from soybeans and rich in various nutrients. In order to further explore the antioxidant peptides of hairy tofu hydrolysates, seven proteases were used to hydrolyze hairy tofu. The results of in vitro radical scavenging activity showed that hairy tofu hydrolysates obtained by pancreatin exhibited the highest antioxidant activity. After Sephadex G-25 gel filtration and reversed-phase high-performance liquid chromatography (RP-HPLC), 97 peptides were identified in the most antioxidant fraction using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)...
February 23, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38382900/small-molecule-and-peptide-drug-conjugates-addressing-integrins-a-story-of-targeted-cancer-treatment
#9
REVIEW
Jannik Paulus, Norbert Sewald
Targeted cancer treatment should avoid side effects and damage to healthy cells commonly encountered during traditional chemotherapy. By combining small molecule or peptidic ligands as homing devices with cytotoxic drugs connected by a cleavable or non-cleavable linker in peptide-drug conjugates (PDCs) or small molecule-drug conjugates (SMDCs), cancer cells and tumours can be selectively targeted. The development of highly affine, selective peptides and small molecules in recent years has allowed PDCs and SMDCs to increasingly compete with antibody-drug conjugates (ADCs)...
February 21, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38374800/comparison-of-the-self-assembly-and-cytocompatibility-of-conjugates-of-fmoc-9-fluorenylmethoxycarbonyl-with-hydrophobic-aromatic-or-charged-amino-acids
#10
JOURNAL ARTICLE
Valeria Castelletto, Lucas de Mello, Emerson Rodrigo da Silva, Jani Seitsonen, Ian W Hamley
The self-assembly in aqueous solution of three Fmoc-amino acids with hydrophobic (aliphatic or aromatic, alanine or phenylalanine) or hydrophilic cationic residues (arginine) is compared. The critical aggregation concentrations were obtained using intrinsic fluorescence or fluorescence probe measurements, and conformation was probed using circular dichroism spectroscopy. Self-assembled nanostructures were imaged using cryo-transmission electron microscopy and small-angle X-ray scattering (SAXS). Fmoc-Ala is found to form remarkable structures comprising extended fibril-like objects nucleating from spherical cores...
February 20, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38317295/detailed-investigation-of-the-binding-abilities-of-the-heterodomain-of-a-multihis-cyclopeptide-toward-cu-ii-ions
#11
JOURNAL ARTICLE
Marco Bortolus, Aleksandra Kotynia, Giacomo Saielli, Paolo Ruzza, Marilena Di Valentin, Mauro Carraro, Justyna Brasuń
Cyclopeptides hold significant relevance in various fields of science and medicine, due to their unique structural properties and diverse biological activities. Cyclic peptides, characterized by intrinsically higher conformational order, exhibit remarkable stability and resistance to proteolytic degradation, making them attractive candidates for developing targeted drug delivery systems. The aim of this work is to elucidate the unique coordination properties of the multi-His cyclic peptide with c(HDHKHPHHKHHP) sequence (HDCP - heterodomain cyclopeptide)...
February 5, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38317283/cyclotides-the-next-generation-in-biopesticide-development-for-eco-friendly-agriculture
#12
REVIEW
Gia-Hoa Tran, Thi-Huyen Tran, Son H Pham, Huy Luong Xuan, Tien T Dang
Chemical pesticides remain the predominant method for pest management in numerous countries. Given the current landscape of agriculture, the development of biopesticides has become increasingly crucial. The strategy empowers farmers to efficiently manage pests and diseases, while prioritizing minimal adverse effects on the environment and human health, hence fostering sustainable management. In recent years, there has been a growing interest and optimism surrounding the utilization of peptide biopesticides for crop protection...
February 5, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38301277/total-synthesis-of-antifungal-lipopeptide-iturin-a-analogues-and-evaluation-of-their-bioactivity-against-f-graminearum
#13
JOURNAL ARTICLE
Periklis Karamanis, Jimmy Muldoon, Cormac D Murphy, Marina Rubini
The pursuit of novel antifungal agents is imperative to tackle the threat of antifungal resistance, which poses major risks to both human health and to food security. Iturin A is a cyclic lipopeptide, produced by Bacillus sp., with pronounced antifungal properties against several pathogens. Its challenging synthesis, mainly due to the laborious synthesis of the β-amino fatty acid present in its structure, has hindered the study of its mode of action and the development of more potent analogues. In this work, a facile synthesis of bioactive iturin A analogues containing an alkylated cysteine residue is presented...
February 1, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38271799/all-hydrocarbon-stapling-enables-improvement-of-antimicrobial-activity-and-proteolytic-stability-of-peptide-figainin-2
#14
JOURNAL ARTICLE
Jingwen Xue, Yinxue Fu, Huang Li, Ting Zhang, Wei Cong, Honggang Hu, Zhiyuan Lu, Fang Yan, Yulei Li
Figainin 2 is a cationic, hydrophobic, α-helical host-defense peptide with 28 residues, which was isolated from the skin secretions of the Chaco tree frog. It shows potent inhibitory activity against both Gram-negative and Gram-positive pathogens and has garnered considerable interest in developing novel classes of natural antibacterial agents. However, as a linear peptide, conformational flexibility and poor proteolytic stability hindered its development as antibacterial agent. To alleviate its susceptibility to proteolytic degradation and improve its antibacterial activity, a series of hydrocarbon-stable analogs of Figainin 2 were synthesized and evaluated for their secondary structure, protease stability, antimicrobial, and hemolytic activities...
January 25, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38268104/identification-chemical-synthesis-and-receptor-binding-of-a-reptilian-gecko-ghrelin
#15
JOURNAL ARTICLE
Hidekazu Katayama, Hiroyuki Kaiya
Ghrelin is known to be a gastrointestinal peptide hormone in vertebrates. It has a unique posttransrational modification, octanoylation, at the Ser side chain of the third position. In this study, we identified the genes encoding ghrelin and its receptor from the Schlegel's Japanese gecko Gekko japonicus. The C-terminal residue of gecko ghrelin was His, although the chemical synthesis method for the O-octanoyl peptide with a C-terminal His residue has not yet been well-established. Acyl-ghrelin has been synthesized using a Ser derivative without side chain protecting group in the solid-phase peptide synthesis, although this synthetic strategy has not yet been well-established...
January 24, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38262069/non-canonical-amino-acid-bioincorporation-into-antimicrobial-peptides-and-its-challenges
#16
REVIEW
George Nkrumah Enninful, Rajesh Kuppusamy, Elvis K Tiburu, Naresh Kumar, Mark D P Willcox
The rise of antimicrobial resistance and multi-drug resistant pathogens has necessitated explorations for novel antibiotic agents as the discovery of conventional antibiotics is becoming economically less viable and technically more challenging for biopharma. Antimicrobial peptides (AMPs) have emerged as a promising alternative because of their particular mode of action, broad spectrum and difficulty that microbes have in becoming resistant to them. The AMPs bacitracin, gramicidin, polymyxins and daptomycin are currently used clinically...
January 23, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38232955/design-synthesis-and-analysis-of-macrobicyclic-peptides-for-targeting-the-g%C3%AE-i-protein
#17
JOURNAL ARTICLE
Anna Pepanian, F Ayberk Binbay, Dehua Pei, Diana Imhof
Bicyclic peptides are important chemical tools that can function, for example, as bioactive ligands switching on/off signaling pathways mediated by guanine nucleotide-binding proteins as bicycles are more broadly applicable. Despite their relevance in medicinal chemistry, the synthesis of such peptides is challenging, and the final yield is highly dependent on the chemical composition and physicochemical properties of the scaffold. We recently discovered novel, state-specific peptide modulators targeting the Gαi protein, namely, GPM-2/GPM-3, by screening a one-bead-two-compound combinatorial library...
January 17, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38220145/solid-phase-peptide-synthesis-in-384-well-plates
#18
JOURNAL ARTICLE
Mischa Schüttel, Edward Will, Gontran Sangouard, Anne Zarda, Sevan Habeshian, Alexander L Nielsen, Christian Heinis
Newer solid-phase peptide synthesis and release strategies enable the production of short peptides with high purity, allowing direct screening for desired bioactivity without prior chromatographic purification. However, the maximum number of peptides that can currently be synthesized per microplate reactor is 96, allowing the parallel synthesis of 384 peptides in modern devices that have space for 4 microplate reactors. To synthesize larger numbers of peptides, we modified a commercially available peptide synthesizer to enable the production of peptides in 384-well plates, which allows the synthesis of 1,536 peptides in one run (4 × 384 peptides)...
January 14, 2024: Journal of Peptide Science
https://read.qxmd.com/read/38531776/10th-international-peptide-conference-of-the-bulgarian-peptide-society
#19
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Journal of Peptide Science
https://read.qxmd.com/read/38531774/giornata-scientifica-della-societ%C3%A3-italiana-peptidi-dedicata-ai-soci-giovani-vittorio-erspamer-and-carlo-pedone-awards-2023
#20
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Journal of Peptide Science
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