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Journal of Peptide Science: An Official Publication of the European Peptide Society

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https://www.readbyqxmd.com/read/28220599/identification-of-laminin-%C3%AE-5-short-arm-peptides-active-for-endothelial-cell-attachment-and-tube-formation
#1
Yamato Kikkawa, Yumika Sugawara, Nozomi Harashima, Shogo Fujii, Kazuki Ikari, Jun Kumai, Fumihiko Katagiri, Kentaro Hozumi, Motoyoshi Nomizu
Laminin-511, a major component of endothelial basement membrane, consists of α5, β1, and γ1 chains. The short arm region of the α5 chain is a structural feature of endothelial laminins. In this study, we identified active sequences for human umbilical vein endothelial cells (HUVECs) using recombinant proteins and synthetic peptides. The short arm of the α5 chain contains three globular domains [laminin N-terminal globular domain, laminin 4 domain a, and laminin 4 domain b (LN, L4a, and L4b)] and three rod-like elements [laminin epidermal growth factor-like domain a, b, and c (LEa, LEb, and LEc)]...
February 21, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28220557/aza-amino-acid-scanning-of-chromobox-homolog-7-cbx7-ligands
#2
Mariam Traoré, Michael Gignac, Ngoc-Duc Doan, Fraser Hof, William D Lubell
An aza-amino acid scan of peptide inhibitors of the chromobox homolog 7 (CBX7) was performed to study the conformational requirements for affinity to the methyllysine reader protein. Twelve azapeptide analogues were prepared using three different approaches employing respectively N-(Fmoc)aza-amino acid chlorides and submonomer azapeptide synthesis to install systematically aza-residues at the first four residues of the peptide, as well as to provide aza-lysine residues possessing saturated and unsaturated side chains...
February 21, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28211253/comparison-of-neurotoxicity-of-different-aggregated-forms-of-a%C3%AE-40-a%C3%AE-42-and-a%C3%AE-43-in-cell-cultures
#3
Lu Fu, Yao Sun, Yongqing Guo, Yan Chen, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Wei Kong, Hui Wu
The abnormal deposition of amyloid-β (Aβ) peptides in the brain is the main neuropathological hallmark of Alzheimer's disease (AD). Amyloid deposits are formed by a heterogeneous mixture of Aβ peptides, among which the most studied are Aβ40 and Aβ42. Aβ40 is abundantly produced in the human brain, but the level of Aβ42 is remarkably increased in the brain of AD patients. Aside from Aβ40 and Aβ42, recent data have raised the possibility that Aβ43 peptides may be instrumental in AD pathogenesis. Besides its length, whether the Aβ aggregated form accounts for the neurotoxicity is also particularly controversial...
February 16, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28198125/design-of-fluorogenic-probes-and-fluorescent-tagged-inhibitors-for-%C3%AE-glutamyl-cyclotransferase
#4
Taku Yoshiya, Hiromi Ii, Shugo Tsuda, Masayoshi Mochizuki, Susumu Kageyama, Tatsuhiro Yoshiki
No abstract text is available yet for this article.
February 15, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28194842/infectivity-inhibition-by-overlapping-synthetic-peptides-derived-from-the-gh-gl-heterodimer-of-herpes-simplex-virus-type-1
#5
Gianluigi Franci, Annarita Falanga, Carla Zannella, Veronica Folliero, Francesca Martora, Marilena Galdiero, Stefania Galdiero, Giancarlo Morelli, Massimiliano Galdiero
Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions, caused by the virus, spread to the nervous system creating several complications. Fusion of host membranes with the viral envelope is mandatory and mediated by a group of glycoproteins conserved in all Herpesviridae subfamilies, such as the glycoproteins B (gB), H (gH), L (gL) and D (gD). We investigated the inhibitory activity mediated by synthetic overlapping peptides spanning the entire ectodomains of gH and gL glycoproteins...
February 14, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28185387/engineering-sortase-a-by-screening-a-second-generation-library-using-phage-display
#6
Lena Schmohl, Jan Bierlmeier, Fabian Gerth, Christian Freund, Dirk Schwarzer
Sortase-mediated ligation is one of the most commonly used chemo-enzymatic techniques for the site-specific modification of proteins. We have established a new library of sortase mutants for directed evolution of sortase substrate selectivity. Phage display screens of this second-generation library yielded sortase mutants that ligate substrate proteins containing an APxTG or FPxTG recognition sequence instead of the canonical LPxTG sorting motif. These findings indicate that the second-generation sortase library is well suited for sortase engineering in order to increase the versatility of sortase-mediated ligation...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28185384/heterochiral-jun-and-fos-bzip-peptides-form-a-coiled-coil-heterodimer-that-is-competent-for-dna-binding
#7
Rui Kamada, Natsumi Nakagawa, Taiji Oyama, Kazuyasu Sakaguchi
Coiled coils, consisting of at least two α-helices, have important roles in the regulation of transcription, cell differentiation, and cell growth. Peptides composed of d-amino acids (d-peptides) have received great attention for their potential in biomedical applications, because they give large diversity for the design of peptidyl drug and are more resistant to proteolytic digestion than l-peptides. However, the interactions between l-peptides/l-protein and d-peptides in the formation of complex are poorly understood...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28185358/effects-of-arginine-and-leucine-substitutions-on-anti-endotoxic-activities-and-mechanisms-of-action-of-cationic-and-amphipathic-antimicrobial-octadecapeptide-from-rice-%C3%AE-amylase
#8
Masayuki Taniguchi, Akihito Ochiai, Ryu Toyoda, Teppei Sato, Eiichi Saitoh, Tetsuo Kato, Takaaki Tanaka
Previously, we showed that the antimicrobial cationic and amphipathic octadecapeptide AmyI-1-18 from rice α-amylase (AmyI-1) inhibited the endotoxic activity of lipopolysaccharide (LPS) from Escherichia coli. In addition, we demonstrated that several AmyI-1-18 analogs containing arginine or leucine substitutions, which were designed on the basis of the helical wheel projection of AmyI-1-18, exhibited higher antimicrobial activity against human pathogenic microorganisms than AmyI-1-18. In the present study, anti-inflammatory (anti-endotoxic) activities of five AmyI-1-18 analogs containing arginine or leucine substitutions were investigated...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28185350/development-of-a-strategy-for-the-total-chemical-synthesis-of-an-allergenic-protein-the-peach-ltp-pru-p-3
#9
Sofie Buhler, Jaap H Akkerdaas, Thelma A Pertinhez, Ronald Van Ree, Arnaldo Dossena, Stefano Sforza, Tullia Tedeschi
The possibility to obtain allergenic proteins by means of total chemical synthesis would be a big step forward in the development of cures to food allergy and in the study of the mechanism of allergic reactions, because this would allow to achieve control at the molecular level over the structure of the product and to study its relationship with the allergenic activity in fine details. This is instead not possible by using allergens produced by extraction from natural sources or by recombinant DNA techniques...
February 10, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28176481/synergistic-activity-profile-of-an-antimicrobial-peptide-against-multidrug-resistant-and-extensively-drug-resistant-strains-of-gram-negative-bacterial-pathogens
#10
Simona Pollini, Jlenia Brunetti, Samanta Sennati, Gian Maria Rossolini, Luisa Bracci, Alessandro Pini, Chiara Falciani
Infection sustained by multidrug-resistant and extensively drug-resistant bacterial pathogens is often untreatable with the standard of care antibiotics, and the combination of anti-infective compounds often represents the only therapeutic strategy to face this major clinical treat. SET-M33 is a novel antimicrobial peptide (AMP) that has demonstrated in vitro and in vivo antimicrobial activity against Gram-negative bacteria and has shown interesting features in preclinical evaluations. Particularly, it showed efficacy against a number of multidrug-resistant and extensively drug-resistant clinical strains of Gram-negative pathogens, in in vitro and in vivo assessments...
February 8, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28150464/adrenomedullin-new-perspectives-of-a-potent-peptide-hormone
#11
Ria Schönauer, Sylvia Els-Heindl, Annette G Beck-Sickinger
Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the calcitonin gene-related peptide (CGRP) superfamily of vasoactive peptide hormones. ADM exhibits a significant vasodilatory potential and plays a key role in various regulatory mechanisms, predominantly in the cardiovascular and lymphatic system. It exerts its effects by activation of the calcitonin receptor-like receptor associated with one of the receptor activity-modifying proteins 2 or 3. ADM was first isolated from human phaeochromocytoma in 1993...
February 2, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28150445/molecular-design-and-synthesis-of-novel-peptides-from-amphibians-skin-acting-as-inhibitors-of-cholinesterase-enzymes
#12
Alvaro Siano, Francisco F Garibotto, Sebastian A Andujar, Hector A Baldoni, Georgina G Tonarelli, Ricardo D Enriz
Cholinesterases are a family of enzymes that catalyze the hydrolysis of neurotransmitter acetylcholine. There are two types of cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which differ in their distribution in the body. Currently, cholinesterase inhibitors (ChEI) represent the treatment of choice for Alzheimer's disease (AD). In this paper, we report the synthesis and inhibitory effect on both enzymes of four new peptides structurally related to P1-Hp-1971 (amphibian skin peptide found in our previous work...
February 2, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28139060/synthesis-of-n-n-dimethylaminopyrene-modified-short-peptides-for-chemical-photocatalysis
#13
Sergej Hermann, Hans-Achim Wagenknecht
The synthesis of peptide-based photocatalysts that use 1-N,N-dimethylaminopyrene as chromophore and their application in photocatalysis is reported. The copper(I)-catalyzed alkyne-azide cycloaddition was applied as key step to prepare the peptide-pyrene conjugates in quantitative yields for different short peptide sequences. The photocatalysts were evaluated for the nucleophilic addition of methanol to 1,1-diphenylethylenes to products with Markovnikov-type orientation The short peptides contain arginine as substrate binding site during photocatalysis, and thus, the reaction was performed without the additive triethylamine that was previously applied as electron shuttle...
January 31, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28139057/synthesis-of-ubiquitylated-histone-h3-using-a-thiirane-linker-for-chemical-ligation
#14
Toru Kawakami, Yuichi Mishima, Hironobu Hojo, Isao Suetake
Post-translational modifications of histone proteins, which form nucleosome cores, play an important role in gene regulation. Ubiquitin modification is one such modification. We previously reported on the use of a thiirane linker to introduce a 1,2-aminothiol moiety at a cysteine residue for native chemical ligation with peptide thioesters, which permitted isopeptide mimetics to be produced. In this report, we describe the preparation of the ubiquitylated full length histone H3 at the 18 position and the construction of tetranucleosomes with recombinant histones H2A, H2B, H4, and DNA, which are slightly more stable than those that are prepared without ubiquitin modification...
January 31, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28139012/evaluation-of-combined-use-of-oxyma-and-hatu-in-aggregating-peptide-sequences
#15
Andrea Caporale, Nunzianna Doti, Annamaria Sandomenico, Menotti Ruvo
Polypeptides are finding increasing applications as therapeutics because of their specificity that often translates into excellent safety, tolerability, and efficacy profiles in humans. New synthetic methodologies for their preparation are thereby continuously sought to reduce the costs associated to chain assembly and purification. Although solid-phase peptide synthesis has become one of the most advanced synthetic procedures at both laboratory and industrial scale, the process is often complicated by aggregation phenomena originating from the combined occurrence of intermolecular and intramolecular hydrogen bonding, hydrophobic interactions, or other effects...
January 31, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28133866/dna-modified-artificial-viral-capsids-self-assembled-from-dna-conjugated-%C3%AE-annulus-peptide
#16
Yoko Nakamura, Saki Yamada, Shoko Nishikawa, Kazunori Matsuura
β-Annulus peptides from tomato bushy stunt virus conjugated with DNAs (dA20 and dT20 ) at the C-terminal were synthesized. The DNA-modified β-annulus peptides self-assembled into artificial viral capsids with sizes of 45-160 nm. ζ-Potential measurements revealed that the DNAs were coated on the surface of artificial viral capsids. Fluorescence assays indicated that the DNAs on the artificial viral capsids were partially hybridized with the complementary DNAs. Moreover, the DNA-modified artificial viral capsids formed aggregates by adding complementary polynucleotides...
January 30, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28133857/pepmat-2016-the-second-conference-on-peptide-based-materials-for-biomedicine-and-nanotechnology
#17
EDITORIAL
Carlos Alemán, Ian W Hamley, Meital Reches
No abstract text is available yet for this article.
January 30, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28127868/peptide-hormones-and-lipopeptides-from-self-assembly-to-therapeutic-applications
#18
J A Hutchinson, S Burholt, I W Hamley
This review describes the properties and activities of lipopeptides and peptide hormones and how the lipidation of peptide hormones could potentially produce therapeutic agents combating some of the most prevalent diseases and conditions. The self-assembly of these types of molecules is outlined, and how this can impact on bioactivity. Peptide hormones specific to the uptake of food and produced in the gastrointestinal tract are discussed in detail. The advantages of lipidated peptide hormones over natural peptide hormones are summarised, in terms of stability and renal clearance, with potential application as therapeutic agents...
January 27, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28120548/ds6-anticandidal-antibiofilm-peptide-against-candida-tropicalis-and-exhibit-synergy-with-commercial-drug
#19
Kusum Singh, Shashank Shekhar, Yudhishthir Yadav, Immaculata Xess, Sharmistha Dey
Antifungal peptides have gained interest as therapeutic agents in recent years because of increased multidrug resistance against present antifungal drugs. This study designed, synthesized and characterized antifungal activity of a small peptide analogue, DS6. This peptide was designed using the template from the N-terminal part of the antifungal protein, Aspergillus giganteous. DS6 inhibited Candida tropicalis (ATCC 13803), as well as its clinical isolates. DS6 was found to be a fungicidal, killing the fungus very rapidly...
January 25, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28120499/three-molecular-forms-of-atrial-natriuretic-peptides-quantitative-analysis-and-biological-characterization
#20
REVIEW
Chiaki Nagai-Okatani, Kenji Kangawa, Naoto Minamino
Atrial natriuretic peptide (ANP) is primarily produced in the heart tissue and plays a pivotal role in maintaining cardiovascular homeostasis in endocrine and autocrine/paracrine systems and has clinical applications as a biomarker and a therapeutic agent for cardiac diseases. ANP is synthesized by atrial cardiomyocytes as a preprohormone that is processed by a signal peptidase and stored in secretory granules as a prohormone. Subsequent proteolytic processing of ANP by corin during the secretion process results in a bioactive form consisting of 28 amino acid residues...
January 25, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
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