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Journal of Atherosclerosis and Thrombosis

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https://www.readbyqxmd.com/read/28819082/dysregulation-of-calpain-proteolytic-systems-underlies-degenerative-vascular-disorders
#1
Takuro Miyazaki, Akira Miyazaki
Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence suggests that dysfunctional calpain proteolytic systems and defective calpain protein metabolism in blood vessels contribute to degenerative disorders...
August 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28794345/heparin-cofactor-ii-a-novel-plausible-link-of-obesity-and-diabetes-with-thrombosis
#2
Yutaka Hasegawa, Yasushi Ishigaki
No abstract text is available yet for this article.
August 10, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28757538/the-roles-of-hypoxia-signaling-in-the-pathogenesis-of-cardiovascular-diseases
#3
Hajime Abe, Hiroaki Semba, Norihiko Takeda
The circulatory system distributes blood flow to each tissue and transports oxygen and nutrients. Peripheral circulation is required to maintain the physiological function in each tissue. Disturbance of circulation, therefore, decreases oxygen delivery, leading to tissue hypoxia which takes place in several cardiovascular disorders including atherosclerosis, pulmonary arterial hypertension and heart failure. While tissue hypoxia can be induced because of cardiovascular disorders, hypoxia signaling itself has a potential to modulate tissue remodeling processes or the severity of the cardiovascular disorders...
July 28, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28757537/knowledge-translation-for-cardiovascular-disease-research-and-management-in-japan
#4
Nusrat S Shommu, Tanvir C Turin
Knowledge translation is an essential and emerging arena in healthcare research. It is the process of aiding the application of research knowledge into clinical practice or policymaking. Individuals at all levels of the health care system, including patients, healthcare professionals, and policymakers, are affected by the gaps that exist between research evidence and practice; the process of knowledge translation plays a role in bridging these gaps and incorporating high-quality clinical research into decision-making...
July 28, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28747590/self-reported-sleep-duration-and-subclinical-atherosclerosis-in-a-general-population-of-japanese-men
#5
Sentaro Suzuki, Hisatomi Arima, Soichiro Miyazaki, Akira Fujiyoshi, Aya Kadota, Naoyuki Takashima, Takashi Hisamatsu, Sayaka Kadowaki, Maryam Zaid, Sayuki Torii, Minoru Horie, Kiyoshi Murata, Katsuyuki Miura, Hirotsugu Ueshima
AIM: There are few data regarding associations between sleep duration and subclinical atherosclerosis in Japan. The aim of this study was to evaluate associations of self-reported sleep duration with calcification in the coronary arteries (CAC) and carotid intima media thickness (IMT) in Japanese men. METHODS: This was a cross-sectional survey of 1093 randomly selected men from Kusatsu City, Japan. Average sleep duration on weekdays was estimated through questionnaire; CAC by computed tomography; and carotid IMT by ultrasonography...
July 26, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28724841/sphingosine-1-phosphate-and-atherosclerosis
#6
Makoto Kurano, Yutaka Yatomi
Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL. Plasma S1P levels are reportedly lower in subjects with coronary artery disease, suggesting that S1P might be deeply involved in the pathogenesis of atherosclerosis. In basic experiments, however, S1P appears to possess both pro-atherosclerotic and anti-atherosclerotic properties; for example, S1P possesses anti-apoptosis, anti-inflammation, and vaso-relaxation properties and maintains the barrier function of endothelial cells, while S1P also promotes the egress and activation of lymphocytes and exhibits pro-thrombotic properties...
July 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28724840/exposure-to-parental-smoking-in-childhood-is-associated-with-high-c-reactive-protein-in-adulthood-the-cardiovascular-risk-in-young-finns-study
#7
Di Wang, Markus Juonala, Jorma S A Viikari, Feitong Wu, Nina Hutri-Kähönen, Olli T Raitakari, Costan G Magnussen
AIM: Children exposed to parental smoking are at increased long-term risk of subclinical atherosclerosis in adulthood. However, it has not been quantified if exposure to parental smoking in childhood is associated with adult systemic inflammation. This study aimed to determine if childhood exposure to parental smoking was associated with high-sensitivity C-reactive protein (hsCRP) in adulthood. METHODS: This longitudinal analysis of 2,511 participants used data from the Cardiovascular Risk in Young Finns Study, a prospective cohort of Finnish children...
July 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28724852/is-childhood-exposure-to-parental-smoking-a-risk-factor-for-future-cardiovascular-disease
#8
Takehiro Michikawa, Tomonori Okamura
No abstract text is available yet for this article.
July 19, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28701626/a-new-factor-for-vascular-calcification-in-chronic-kidney-disease-computed-tomography-based-renal-parenchymal-volume
#9
Masato Nishimura
No abstract text is available yet for this article.
July 12, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674325/is-the-association-between-dietary-trans-fatty-acids-and-insulin-resistance-remarkable-in-japan
#10
Wao Tsutsui, Yoshio Fujioka
No abstract text is available yet for this article.
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674323/newly-developed-rat-model-of-chronic-kidney-disease-mineral-bone-disorder
#11
Kentaro Watanabe, Hideki Fujii, Shunsuke Goto, Kentaro Nakai, Keiji Kono, Shuhei Watanabe, Masami Shinohara, Shinichi Nishi
AIM: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD-MBD in a newly developed CKD rat model. METHODS: We used male Sprague-Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674322/oxidative-stress-is-closely-associated-with-increased-arterial-stiffness-especially-in-aged-male-smokers-without-previous-cardiovascular-events-a-cross-sectional-study
#12
Tomonori Sugiura, Yasuaki Dohi, Hiroyuki Takase, Sumiyo Yamashita, Satoshi Fujii, Nobuyuki Ohte
AIM: Cigarette smoking is one of the major risk factors for cardiovascular diseases and induces deleterious vascular damage. Oxidative stress is involved in vascular inflammation, the process of atherosclerosis. The purpose of the present study was to investigate whether the effects of oxidative stress on the arterial wall differ between smokers and non-smokers. METHODS: Male smokers and non-smokers without physical deconditioning who visited Enshu hospital for an annual physical check-up were enrolled in the study...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674321/incremental-prognostic-value-of-coronary-computed-tomography-angiography-high-risk-plaque-characteristics-in-asymptomatic-patients
#13
Kazuhisa Takamura, Shinichiro Fujimoto, Takeshi Kondo, Makoto Hiki, Yuko Kawaguchi, Etsuro Kato, Hiroyuki Daida
AIM: Coronary computed tomography angiography (CCTA) findings of positive remodeling (index >1.1) and low-attenuation plaque (<30 Hounsfield units) are recognized as CT-verified high-risk plaque (CT-HRP). Therefore, we investigated the incremental prognostic value of evaluation of plaque characteristics using CCTA in asymptomatic patients. METHODS: Overall, 495 consecutive patients without any known coronary artery disease who underwent CCTA were included in this study...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674320/effects-of-24-week-aerobic-and-resistance-training-on-carotid-artery-intima-media-thickness-and-flow-velocity-in-elderly-women-with-sarcopenic-obesity
#14
Jinkee Park, Yoochan Kwon, Hyuntea Park
AIM: Sarcopenic obesity (SO) is closely associated with cardiovascular disease (CVD) in elderly women. Increases in body fat and decreases in muscle mass are closely associated with increased carotid intima-media thickness (CIMT). The aim of this study was to examine the influence of a 24-week aerobic and resistance training program on carotid parameters in SO. METHODS: Fifty elderly women (74.1±6.1 years) with SO were randomly divided into an exercise group and a control group...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28652525/sugar-sweetened-beverages-consumption-positively-associated-with-the-risks-of-obesity-and-hypertriglyceridemia-among-children-aged-7-18-years-in-south-china
#15
Baoting He, Weiqing Long, Xiuhong Li, Wenhan Yang, Yajun Chen, Yanna Zhu
AIMS: Excessive consumption of sugar-sweetened beverages (SSBs) may increase the prevalence of obesity and other metabolic risk factors. However, data regarding the relationship between SSB consumption and metabolic risk factors are insufficient in Chinese children. Hence, we aimed to explore the association between SSB consumption and cardio-metabolic risk factors in children aged 7-18 years living in South China. METHODS: A cross-sectional study was conducted in a total of 2,032 children aged 7-18 years were enrolled, including 1,013 boys and 1,019 girls...
June 23, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28592705/smoking-cessation-without-educational-instruction-could-promote-the-development-of-metabolic-syndrome
#16
Shin Takayama, Hiroyuki Takase, Takamitsu Tanaka, Tomonori Sugiura, Nobuyuki Ohte, Yasuaki Dohi
AIM: Smoking cessation is particularly important for maintaining health; however, the subsequent risk of an increased body weight is of major concern. The present study investigated the influence of smoking cessation on the incidence of metabolic syndrome and its components in the Japanese general population. METHODS: This study enrolled individuals without metabolic syndrome or a history of smoking via our annual health checkup program (n=5,702, 55.2±11.5 years)...
June 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28592707/endothelial-nitric-oxide-synthase-independent-pleiotropic-effects-of-pitavastatin-against-atherogenesis-and-limb-ischemia-in-mice
#17
Takeshi Mitsuhashi, Ryoko Uemoto, Kazue Ishikawa, Sumiko Yoshida, Yasumasa Ikeda, Shusuke Yagi, Toshio Matsumoto, Masashi Akaike, Ken-Ichi Aihara
AIM: Statins have a protective impact against cardiovascular diseases through not only lipid-lowering effects but also pleiotropic effects, including activation of the endothelial nitric oxide synthase (eNOS) system. We aimed to clarify the protective effects of a statin against atherogenesis and ischemia in eNOS(-/-) mice. METHODS: Study 1. eNOS(-/-) Apolipoprotein E (ApoE)(-/-) mice were treated with a vehicle or pitavastatin (0.3 mg/kg/day) for 4 weeks...
June 6, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28552852/the-effect-of-n-3-pufa-on-the-development-of-abdominal-aortic-aneurysm
#18
Nobuhiro Zaima
No abstract text is available yet for this article.
May 26, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28539547/association-of-a-low-serum-eicosapentaenoic-acid-arachidonic-acid-ratio-with-the-risk-of-acute-venous-thromboembolism
#19
Shigemasa Tani
No abstract text is available yet for this article.
May 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28674324/flow-mediated-dilatation-as-a-biomarker-in-vascular-surgery-research
#20
Kirthi Bellamkonda, Matthew Williams, Ashok Handa, Regent Lee
Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohorts such as the Framingham Heart Study, Young Finns Study, and Gutenberg Heart Study...
August 1, 2017: Journal of Atherosclerosis and Thrombosis
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