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Journal of Atherosclerosis and Thrombosis

Yoko Yoshida, Hideki Kato, Yoichiro Ikeda, Masaomi Nangaku
Atypical hemolytic uremic syndrome (aHUS) is a type of thrombotic microangiopathy (TMA) defined by thrombocytopenia, microangiopathic hemolytic anemia, and renal failure. aHUS is caused by uncontrolled complement activation in the alternative pathway (AP). A variety of genetic defects in complement-related factors or acquired autoantibodies to the complement regulators have been found in 50 to 60% of all cases. Recently, however, the classification and diagnosis of aHUS are becoming more complicated. One reason for this is that some factors, which have not been regarded as complement-related factors, have been reported as predisposing factors for phenotypic aHUS...
November 2, 2018: Journal of Atherosclerosis and Thrombosis
Cecilia Kimani, Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Maryam Zaid, Sayaka Kadowaki, Takashi Hisamatsu, Hisatomi Arima, Minoru Horie, Hirotsugu Ueshima
AIMS: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. METHODS: We examined a random sample of 1035 Japanese men aged 40-79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method...
November 1, 2018: Journal of Atherosclerosis and Thrombosis
Yutaka Igarashi, Nobuhiko Akazawa, Seiji Maeda
AIM: The purpose of the current work was to review the effects of regular aerobic exercise on serum lipid and lipoprotein levels in East Asians using meta-analysis. METHODS: The randomized controlled trials analyzed involved healthy adults who were East Asians with a mean age ≥40 years, an exercise group that only performed regular aerobic exercise, and a control group that did not carry out exercise-related intervention; the trials indicated mean high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), or triglyceride (TG)...
October 31, 2018: Journal of Atherosclerosis and Thrombosis
Shinji Koba
No abstract text is available yet for this article.
October 29, 2018: Journal of Atherosclerosis and Thrombosis
Kouji Kajinami, Asuka Ozaki, Yuki Tajima, Shizuya Yamashita, Hidenori Arai, Tamio Teramoto
AIM: Statins are generally well-tolerated but some patients develop adverse events and down-titrate or discontinue statins. It is important to understand the frequency of dyslipidemia patients with the inability to continue statins. The aim of the present study was to identify the frequency of high-risk dyslipidemia patients who are unable to take or not taking statins for any reason using Japanese hospital claims database. METHODS: 2,527,405 dyslipidemia patients with atherosclerotic cardiovascular disease were investigated between April 2008 and September 2017...
October 26, 2018: Journal of Atherosclerosis and Thrombosis
Hiroko Iino, Tomoko Okano, Masao Daimon, Kazuno Sasaki, Mayumi Chigira, Tomoko Nakao, Yoshiko Mizuno, Tsutomu Yamazaki, Makoto Kurano, Yutaka Yatomi, Yuki Sumi, Tetsuo Sasano, Tetsuro Miyata
AIM: We investigated the clinical usefulness of carotid arterial strain and the strain rate for evaluating the progression of arteriosclerosis measured using a two-dimensional speckle-tracking method in carotid ultrasonography. METHODS: We enrolled 259 participants (age: 64±12 years; men: 149; women: 110) in this retrospective analysis. The circumferential strain and the strain rate were measured in bilateral common carotid arteries, and the lowest values were used for the analyses...
October 20, 2018: Journal of Atherosclerosis and Thrombosis
Kazuo Kitagawa, Naohisa Hosomi, Yoji Nagai, Tatsuo Kagimura, Toshiho Ohtsuki, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masakazu Nakamura, Masayasu Matsumoto
AIMS: To investigate the relative contribution of on-treatment low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) to the risk of recurrent stroke and transient ischemic attack (TIA) in patients with history of ischemic stroke. METHODS: A total of 1095 patients with non-cardioembolic ischemic stroke were randomized into two groups: control and patients receiving 10 mg of pravastatin per day. After excluding 18 patients who did not have baseline CRP data, the effects of LDL cholesterol and CRP on recurrent stroke and TIA were prospectively assessed in 1077 patients...
October 15, 2018: Journal of Atherosclerosis and Thrombosis
Xuewei Xie, Xianwei Wang, Zixiao Li, Xingquan Zhao, Zhongrong Miao, Liping Liu, Hao Li, Xia Meng, Yongjun Wang, Yilong Wang
AIM: The impact of international normalized ratio (INR) on prognosis after acute ischemic stroke without anticoagulation therapy is unclear. Herein, the association between baseline INR and stroke outcomes in patients without anticoagulation therapy was investigated. METHODS: A total of 14,782 ischemic stroke patients from the China National Stroke Registry Ⅱ were included in this analysis. The period of follow-up was 1 year after stroke onset. Multivariate logistic regression models were used to estimate the relationship between INR and stroke outcomes including all-cause death, recurrent stroke, composite end point, and poor functional outcome...
October 12, 2018: Journal of Atherosclerosis and Thrombosis
Misa Ito, Katsunori Ikewaki
No abstract text is available yet for this article.
October 11, 2018: Journal of Atherosclerosis and Thrombosis
Hisataka Yamazaki, Manabu Takahashi, Tetsuji Wakabayashi, Kent Sakai, Daisuke Yamamuro, Akihito Takei, Shoko Takei, Shuichi Nagashima, Hiroaki Yagyu, Motohiro Sekiya, Ken Ebihara, Shun Ishibashi
AIM: Acyl-CoA cholesterol acyltransferase 1 (ACAT1) esterifies free cholesterol to cholesteryl esters (CE), which are subsequently hydrolyzed by neutral cholesterol ester hydrolase 1 (NCEH1). The elimination of ACAT1 in vitro reduces the amounts of CE accumulated in Nceh1-deficient macrophages. The present study aimed at examining whether the loss of ACAT1 attenuates atherosclerosis which is aggravated by the loss of NCEH1 in vivo. METHODS: Low density lipoprotein receptor (Ldlr)-deficient mice were transplanted with bone marrow from wild-type mice and mice lacking ACAT1, NCEH1, or both...
October 4, 2018: Journal of Atherosclerosis and Thrombosis
Atsushi Nohara, Yoshihiko Otsubo, Koji Yanagi, Masayuki Yoshida, Katsunori Ikewaki, Mariko Harada-Shiba, Agnieszka Jurecka
AIM: Lomitapide is an approved lipid-lowering agent indicated as adjunct to low-fat diet and standard lipid-lowering therapies (LLTs) including lipoprotein apheresis for the treatment of homozygous familial hypercholesterolemia (HoFH). Clinical data from Phase 3 studies have demonstrated the prolonged lipid-lowering capacity of lomitapide in patients with HoFH. We assessed the long-term lipid-lowering capacity of daily oral lomitapide in a cohort of Japanese patients with HoFH enrolled in a Phase 3 extension study...
September 26, 2018: Journal of Atherosclerosis and Thrombosis
Demet Ozkaramanli Gur, Ozcan Gur, Savas Guzel, Aydin Akyuz, Selami Gurkan, Seref Alpsoy, Nisa Simge Gulec, Fatma Koc
AIM: Peripheral artery disease (PAD) is a manifestation of atherosclerosis with poor prognosis. It is generally complicated by vascular calcification, which is located either in the intima as patchy infiltrates; or circumferentially in the media, also known as medial arterial calcification (MAC). Obstructive PAD is reflected by low anklebrachial index (ABI ≤ 0.9), whereas MAC is revealed by high ABI (ABI >1.4). Considering the increase in cardiovascular mortality at both ends of the ABI spectrum, this study aimed to explore the underlying pathology through cytokines with established prognostic significance; namely pentraxin-3(PTX3), high sensitivity C-reactive protein (hsCRP), copeptin, soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), NT-proBNP, and neopterin...
September 25, 2018: Journal of Atherosclerosis and Thrombosis
Kenji Sakata, Tadatsugu Gamou, Hayato Tada, Kenshi Hayashi, Hidekazu Ino, Masakazu Yamagishi
AIM: The prospective, randomized, multicenter Myocardial Ischemia Treated with Percutaneous Coronary Intervention and Plaque Regression by Lipid Lowering & Blood Pressure Controlling assessed by Intravascular Ultrasonography (MILLION) study demonstrated that combined treatment with atorvastatin and amlodipine enhanced coronary artery plaque regression. Although the baseline high-sensitive C-reactive protein (hs-CRP) reportedly plays an important role in atherogenesis, few data exist regarding the relationship between hs-CRP and plaque regression in patients receiving a combined atorvastatin and amlodipine therapy...
September 21, 2018: Journal of Atherosclerosis and Thrombosis
Ehimen C Aneni, Chukwuemeka U Osondu, Javier De La Cruz, Seth S Martin, Michael J Blaha, Adnan Younus, Theodore Feldman, Arthur S Agatston, Emir Veledar, Khurram Nasir
AIMS: There is limited knowledge about the association of lipoprotein particles and markers of coronary atherosclerosis such as coronary artery calcification (CAC) in relatively young high-risk persons. This study examines the association of lipoprotein subfractions and CAC in high cardiometabolic risk individuals. METHODS: The study presents analysis from baseline data of a randomized trial targeted at high-risk workers. Employees of Baptist Health South Florida with metabolic syndrome or diabetes were recruited...
September 14, 2018: Journal of Atherosclerosis and Thrombosis
Yoshio Fujioka
No abstract text is available yet for this article.
September 13, 2018: Journal of Atherosclerosis and Thrombosis
Yuichi Saito, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi
AIM: Serum uric acid (SUA) level is known to have a prognostic value in patients with acute coronary syndrome (ACS). Endothelial function plays an important role in the development of cardiovascular disease. Although relation between SUA level and endothelial function has been previously studied in various populations, it is partially understood in patients with ACS. METHODS: A total of 55 patients with ACS with measurements of SUA level and reactive hyperemia index (RHI) to evaluate endothelial function were included...
September 13, 2018: Journal of Atherosclerosis and Thrombosis
Hiroki Kobayashi, Hiromasa Otsuka, Mitsuru Yanai, Motohiko Hara, Mikano Hishiki, Masayoshi Soma, Masanori Abe
AIM: Adiponectin exhibits its biological effects through adiponectin receptors (AdipoR1 and AdipoR2), which are distributed in the kidneys, and activation of those receptors could prevent or ameliorate diabetic nephropathy. This study aimed to evaluate the associations between AdipoR single nucleotide polymorphisms (SNPs) and kidney function in an elderly Japanese population. METHODS: A total of 271 elderly Japanese volunteers underwent anthropometric and laboratory tests (cystatin C-based eGFR and total and high molecular weight adiponectin levels at baseline and a follow-up visit)...
August 22, 2018: Journal of Atherosclerosis and Thrombosis
Masashi Fukunaga, Daizo Kawasaki, Machiko Nishimura, Masanao Yamagami, Reiko Fujiwara, Tsuyoshi Nakata
AIM: The aim of this study was to investigate the clinical effect of planned endovascular therapy (EVT) for critical limb ischemia (CLI) patients with tissue loss. Although several rounds of EVT for CLI patients are required for complete wound healing, time required for complete wound healing depends on the wound severity. We hypothesized that planned EVT might reduce the time to wound healing. METHODS: A total of 89 limbs of 76 CLI patients with tissue loss, who had undergone more than at least two EVTs were included in this study...
August 21, 2018: Journal of Atherosclerosis and Thrombosis
Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-Ichi Aihara, Masashi Akaike, Masataka Sata
AIM: It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. METHODS: A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled...
August 21, 2018: Journal of Atherosclerosis and Thrombosis
Kensaku Nishihira
No abstract text is available yet for this article.
November 1, 2018: Journal of Atherosclerosis and Thrombosis
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