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Journal of Atherosclerosis and Thrombosis

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https://www.readbyqxmd.com/read/30210088/problems-that-physicians-should-notice-for-better-treatment-of-hypercholesterolemia-in-japan
#1
Yoshio Fujioka
No abstract text is available yet for this article.
September 13, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30210087/relation-of-elevated-serum-uric-acid-level-to-endothelial-dysfunction-in-patients-with-acute-coronary-syndrome
#2
Yuichi Saito, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi
AIM: Serum uric acid (SUA) level is known to have a prognostic value in patients with acute coronary syndrome (ACS). Endothelial function plays an important role in the development of cardiovascular disease. Although relation between SUA level and endothelial function has been previously studied in various populations, it is partially understood in patients with ACS. METHODS: A total of 55 patients with ACS with measurements of SUA level and reactive hyperemia index (RHI) to evaluate endothelial function were included...
September 13, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30197400/a-novel-selective-ppar%C3%AE-modulator-spparm%C3%AE-k-877-pemafibrate-attenuates-postprandial-hypertriglyceridemia-in-mice
#3
Masami Sairyo, Takuya Kobayashi, Daisaku Masuda, Koutaro Kanno, Yinghong Zhu, Takeshi Okada, Masahiro Koseki, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
No abstract text is available yet for this article.
September 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30146614/cardioprotective-effects-of-high-density-lipoprotein-beyond-its-anti-atherogenic-action
#4
Manabu Nagao, Hideto Nakajima, Ryuji Toh, Ken-Ichi Hirata, Tatsuro Ishida
High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is transported to the liver, reducing the atherosclerotic burden. However, mounting evidence indicates that HDL also has pleiotropic properties, such as anti-inflammatory, anti-oxidative, and vasodilatory properties, which may contribute in reducing the incidence of heart failure...
August 27, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30135333/adiponectin-receptor-gene-polymorphisms-are-associated-with-kidney-function-in-elderly-japanese-populations
#5
Hiroki Kobayashi, Hiromasa Otsuka, Mitsuru Yanai, Motohiko Hara, Mikano Hishiki, Masayoshi Soma, Masanori Abe
AIM: Adiponectin exhibits its biological effects through adiponectin receptors (AdipoR1 and AdipoR2), which are distributed in the kidneys, and activation of those receptors could prevent or ameliorate diabetic nephropathy. This study aimed to evaluate the associations between AdipoR single nucleotide polymorphisms (SNPs) and kidney function in an elderly Japanese population. METHODS: A total of 271 elderly Japanese volunteers underwent anthropometric and laboratory tests (cystatin C-based eGFR and total and high molecular weight adiponectin levels at baseline and a follow-up visit)...
August 22, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30135330/clinical-effects-of-planned-endovascular-therapy-for-critical-limb-ischemia-patients-with-tissue-loss
#6
Masashi Fukunaga, Daizo Kawasaki, Machiko Nishimura, Masanao Yamagami, Reiko Fujiwara, Tsuyoshi Nakata
AIM: The aim of this study was to investigate the clinical effect of planned endovascular therapy (EVT) for critical limb ischemia (CLI) patients with tissue loss. Although several rounds of EVT for CLI patients are required for complete wound healing, time required for complete wound healing depends on the wound severity. We hypothesized that planned EVT might reduce the time to wound healing. METHODS: A total of 89 limbs of 76 CLI patients with tissue loss, who had undergone more than at least two EVTs were included in this study...
August 21, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30135329/association-of-decreased-docosahexaenoic-acid-level-after-statin-therapy-and-low-eicosapentaenoic-acid-level-with-in-stent-restenosis-in-patients-with-acute-coronary-syndrome
#7
Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-Ichi Aihara, Masashi Akaike, Masataka Sata
AIM: It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. METHODS: A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled...
August 21, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30111669/circulating-aminoterminal-propeptide-of-type-iii-procollagen-as-a-biomarker-of-cardiovascular-events-in-patients-undergoing-hemodialysis
#8
Masato Nishimura, Toshiko Tokoro, Toru Takatani, Nodoka Sato, Tetsuya Hashimoto, Hiroyuki Kobayashi, Toshihiko Ono
AIM: Type Ⅲ collagen abundantly exists in the cardiovascular system, including the aorta and heart. We prospectively investigated whether serum levels of aminoterminal propeptide of type Ⅲ procollagen (PⅢNP), a circulating biomarker of cardiovascular fibrosis, could predict cardiovascular events in patients undergoing hemodialysis. METHODS: Serum PⅢNP concentrations were measured in 244 patients undergoing maintenance hemodialysis (men, 126; women, 118; mean age, 64±11 years; dialysis duration, 11...
August 15, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30089755/vegetable-protein-intake-was-inversely-associated-with-cardiovascular-mortality-in-a-15-year-follow-up-study-of-a-general-japanese-population
#9
Ayako Kurihara, Tomonori Okamura, Daisuke Sugiyama, Aya Higashiyama, Makoto Watanabe, Nagako Okuda, Aya Kadota, Naoko Miyagawa, Akira Fujiyoshi, Katsushi Yoshita, Takayoshi Ohkubo, Akira Okayama, Katsuyuki Miura, Hirotsugu Ueshima
AIM: To examine the relationship between the intake of dietary vegetable protein and CVD mortality in a 15-year follow-up study of a representative sample of the Japanese population. METHODS: A total of 7,744 participants aged 30 years or older (3,224 males and 4,520 females) who were free of CVD at baseline were included in this analysis. Vegetable protein intake (% energy) was assessed using a three-day semi-weighed dietary record at baseline. Multivariable-adjusted hazard ratios (HRs) were calculated using Cox's proportional hazards model after adjusting for confounding factors...
August 9, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30089757/carotid-intima-media-thickness-in-patients-with-ankylosing-spondylitis-a-systematic-review-and-updated-meta-analysis
#10
Yaping Yuan, Jiajia Yang, Xu Zhang, Renfang Han, Mengya Chen, Xingxing Hu, Yubo Ma, Meng Wu, Mengmeng Wang, Shengqian Xu, Faming Pan
AIM: Inflammatory arthritis (IA) diseases are relevant with subclinical atherosclerosis, but the data in ankylosing spondylitis (AS) were inconsistent. Therefore, we performed this meta-analysis to explore the relationship between the marker of subclinical atherosclerosis (carotid intima-media thickness (IMT)) and AS. METHODS: We performed a systematic literature review using PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM) databases up to March 2018...
August 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30089756/relationship-between-cardiorespiratory-fitness-and-non-high-density-lipoprotein-cholesterol-a-cohort-study
#11
Natsumi Watanabe, Susumu S Sawada, Kazunori Shimada, I-Min Lee, Yuko Gando, Haruki Momma, Ryoko Kawakami, Motohiko Miyachi, Yumiko Hagi, Chihiro Kinugawa, Takashi Okamoto, Koji Tsukamoto, Steven N Blair
AIM: Recent studies have suggested that non-high-density lipoprotein cholesterol (non-HDL-C) may be a good marker of coronary heart disease and cardiovascular disease risk. Therefore, we investigated the relationship between cardiorespiratory fitness (CRF) and non-HDL-C. METHODS: We evaluated CRF and the incidence of high level of non-HDL-C in 4,067 Japanese men without dyslipidemia. The participants were given a submaximal exercise test, a medical examination, and questionnaires on their health habits in 1986...
August 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30078832/genetic-variations-triglycerides-and-atherosclerotic-disease
#12
Hayato Tada, Masa-Aki Kawashiri
No abstract text is available yet for this article.
August 4, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30068830/an-intriguing-and-important-concept-relevant-to-oxidized-low-density-lipoprotein-and-atherogenesis-is-still-problematic-for-its-contribution-to-the-better-understanding-of-clinical-atherosclerosis
#13
https://www.readbyqxmd.com/read/30068817/efficacy-and-safety-of-alirocumab-in-japanese-patients-with-diabetes-mellitus-post-hoc-subanalysis-of-odyssey-japan
#14
Tamio Teramoto, Makiko Usami, Yoshiharu Takagi, Marie T Baccara-Dinet
AIM: To examine the efficacy and safety of alirocumab in Japanese patients with dyslipidemia with or without diabetes mellitus (DM). METHODS: Patients (n=216) with heterozygous familial hypercholesterolemia (heFH), non-FH at high cardiovascular risk with coronary artery disease (CAD), or category III (primary prevention) were enrolled; 148 (68.5%) patients had a diagnosis of DM at baseline. Patients were randomized (2:1), with stratification factor (heFH, non-FH), to alirocumab (75 mg every 2 weeks [Q2W] with increase to 150 mg if week 8 LDL-C was above predefined limits) or placebo subcutaneously for 52 weeks on top of stable statin therapy...
August 1, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30068816/identification-of-metabolites-associated-with-onset-of-cad-in-diabetic-patients-using-ce-ms-analysis-a-pilot-study
#15
Kazuo Omori, Naoto Katakami, Yuichi Yamamoto, Hiroyo Ninomiya, Mitsuyoshi Takahara, Taka-Aki Matsuoka, Takeshi Bamba, Eiichiro Fukusaki, Iichiro Shimomura
AIM: Coronary artery disease (CAD) is the result of a complex metabolic disorder caused by various environmental and genetic factors. Metabolomics is a potential tool for identifying biomarkers for better risk classification and for understanding the pathophysiological mechanisms of CAD. With this background, we performed a pilot study to identify metabolites associated with the future onset of CAD in patients with type 2 diabetes. METHODS: Sixteen subjects who suffered from CAD event during the observation period and 39 non-CAD subjects who were matched to the CAD subjects for Framingham Coronary Heart Disease Risk Score, diabetes duration, and HbA1c were selected...
August 1, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/30047512/usual-dietary-intake-and-risk-of-stroke
#16
Hisashi Adachi
No abstract text is available yet for this article.
July 24, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29998912/post-prandial-remnant-lipoprotein-metabolism-in-sitosterolemia
#17
Hayato Tada, Akihiro Nomura, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Masa-Aki Kawashiri
AIM: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia. METHODS: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2 ); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL)...
July 12, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29962379/association-between-subclinical-atherosclerosis-markers-and-the-level-of-accumulated-advanced-glycation-end-products-in-the-skin-of-patients-with-diabetes
#18
Hiroyo Ninomiya, Naoto Katakami, Ihoko Sato, Saeko Osawa, Yuichi Yamamoto, Mitsuyoshi Takahara, Dan Kawamori, Taka-Aki Matsuoka, Iichiro Shimomura
AIM: The level of accumulated advanced glycation end-products (AGEs) in the skin has been shown to predict the risk of complications in patients with diabetes mellitus (DM). Recently, the level of accumulated fluorescent AGEs in the skin has become measurable as skin autofluorescence (skin AF) using a non-invasive apparatus, autofluorescence reader. The purpose of this study was to evaluate the association between skin AF and the subclinical atherosclerosis markers, especially endothelial dysfunction, in patients with DM...
June 30, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29962378/glp-1-receptor-agonist-exendin-4-attenuates-nr4a-orphan-nuclear-receptor-nor1-expression-in-vascular-smooth-muscle-cells
#19
Hiroyuki Takahashi, Takashi Nomiyama, Yuichi Terawaki, Takako Kawanami, Yuriko Hamaguchi, Tomoko Tanaka, Makito Tanabe, Dennis Bruemmer, Toshihiko Yanase
AIMS: Recently, incretin therapy has attracted increasing attention because of its potential use in tissue-protective therapy. Neuron-derived orphan receptor 1 (NOR1) is a nuclear orphan receptor that regulates vascular smooth muscle cell (VSMC) proliferation. In the present study, we investigated the vascular-protective effect of Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, by inhibiting NOR1 expression in VSMCs. METHODS: We classified 7-week-old male 129X1/SvJ mice into control group and Ex-4 low- and high-dose-treated groups fed normal or high-fat diets, respectively...
June 30, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29962381/clinical-and-economic-analysis-of-lipid-goal-attainments-in-chinese-patients-with-acute-coronary-syndrome-who-received-post-percutaneous-coronary-intervention
#20
Yun Wang, Bryan Ping Yen Yan, Brian Tomlinson, Michael Bruce Nichol, Vivian Wing Yan Lee
AIM: The recommended low-density lipoprotein cholesterol (LDL-C) levels of the guideline may be appropriate for Caucasian patients but not for other ethnic groups. METHODS: A cohort study was conducted in Hong Kong, and acute coronary syndrome (ACS) patients who received percutaneous coronary intervention (PCI) between 2005 and 2015 were enrolled. The primary outcomes of interest were the total cost of care and cardiovascular-related cost during one-year follow-up...
June 29, 2018: Journal of Atherosclerosis and Thrombosis
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