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Journal of Atherosclerosis and Thrombosis

Tsutomu Hirano
Accumulating clinical evidence has suggested serum triglyceride (TG) is a leading predictor of atherosclerotic cardiovascular disease, comparable to low-density lipoprotein (LDL)-cholesterol (C) in populations with type 2 diabetes, which exceeds the predictive power of hemoglobinA1c. Atherogenic dyslipidemia in diabetes consists of elevated serum concentrations of TG-rich lipoproteins (TRLs), a high prevalence of small dense low-density lipoprotein (LDL), and low concentrations of cholesterol-rich high-density lipoprotein (HDL)2-C...
July 12, 2018: Journal of Atherosclerosis and Thrombosis
Hayato Tada, Akihiro Nomura, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Masa-Aki Kawashiri
AIM: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia. METHODS: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m2 ); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL)...
July 12, 2018: Journal of Atherosclerosis and Thrombosis
Hiroyo Ninomiya, Naoto Katakami, Ihoko Sato, Saeko Osawa, Yuichi Yamamoto, Mitsuyoshi Takahara, Dan Kawamori, Taka-Aki Matsuoka, Iichiro Shimomura
AIM: The level of accumulated advanced glycation end-products (AGEs) in the skin has been shown to predict the risk of complications in patients with diabetes mellitus (DM). Recently, the level of accumulated fluorescent AGEs in the skin has become measurable as skin autofluorescence (skin AF) using a non-invasive apparatus, autofluorescence reader. The purpose of this study was to evaluate the association between skin AF and the subclinical atherosclerosis markers, especially endothelial dysfunction, in patients with DM...
June 30, 2018: Journal of Atherosclerosis and Thrombosis
Hiroyuki Takahashi, Takashi Nomiyama, Yuichi Terawaki, Takako Kawanami, Yuriko Hamaguchi, Tomoko Tanaka, Makito Tanabe, Dennis Bruemmer, Toshihiko Yanase
AIMS: Recently, incretin therapy has attracted increasing attention because of its potential use in tissue-protective therapy. Neuron-derived orphan receptor 1 (NOR1) is a nuclear orphan receptor that regulates vascular smooth muscle cell (VSMC) proliferation. In the present study, we investigated the vascular-protective effect of Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, by inhibiting NOR1 expression in VSMCs. METHODS: We classified 7-week-old male 129X1/SvJ mice into control group and Ex-4 low- and high-dose-treated groups fed normal or high-fat diets, respectively...
June 30, 2018: Journal of Atherosclerosis and Thrombosis
Yun Wang, Bryan Ping Yen Yan, Brian Tomlinson, Michael Bruce Nichol, Vivian Wing Yan Lee
AIM: The recommended low-density lipoprotein cholesterol (LDL-C) levels of the guideline may be appropriate for Caucasian patients but not for other ethnic groups. METHODS: A cohort study was conducted in Hong Kong, and acute coronary syndrome (ACS) patients who received percutaneous coronary intervention (PCI) between 2005 and 2015 were enrolled. The primary outcomes of interest were the total cost of care and cardiovascular-related cost during one-year follow-up...
June 29, 2018: Journal of Atherosclerosis and Thrombosis
Yihui Liu, Jiang Xu, Wanyun Tao, Rong Yu, Xinjiang Zhang
AIM: Dyslipidemia is the most common lipid metabolism disorder in humans, and its etiology remains elusive. Hypertriglyceridemia (HTG) is a type of dyslipidemia that contributes to atherosclerosis and coronary heart disease. Previous studies have demonstrated that mutations in lipoprotein lipase (LPL), apolipoprotein CII (APOC2), apolipoprotein AV (APOA5), glycosylphosphatidylinositol anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1), and glycerol-3 phosphate dehydrogenase 1 (GPD1) are responsible for HTG by using genomic microarrays and next-generation sequencing...
June 15, 2018: Journal of Atherosclerosis and Thrombosis
Atsushi Nohara, Hirotoshi Ohmura, Hiroaki Okazaki, Masatsune Ogura, Kazuo Kitagawa, Masahiro Koseki, Kayoko Sato, Kazuhisa Tsukamoto, Shizuya Yamashita
No abstract text is available yet for this article.
June 13, 2018: Journal of Atherosclerosis and Thrombosis
Chika Okada, Hironori Imano, Kazumasa Yamagishi, Renzhe Cui, Mitsumasa Umesawa, Koutatsu Maruyama, Isao Muraki, Mina Hayama-Terada, Yuji Shimizu, Tomoko Sankai, Takeo Okada, Masahiko Kiyama, Akihiko Kitamura, Hiroyasu Iso
AIMS: The frequency of breakfast intake has been reported to be inversely associated with the risk of cardiovascular events; however, it is uncertain what the impact of the energy and nutrient intakes from breakfast are. We assessed the association between these intakes from breakfast and the risk of stroke prospectively. METHODS: In a baseline survey of four Japanese communities between 1981 and 1990, we enrolled 3 248 residents (1 662 men and 1 586 women) aged 40-59 years who were free from stroke and heart disease and who responded to the 24-hour dietary recall survey...
June 13, 2018: Journal of Atherosclerosis and Thrombosis
Long Jiang, Lu-Ya Wang, Xiao-Shu Cheng
Familial hypercholesterolemia (FH) is an autosomal-dominant disorder that is characterized by high plasma low-density lipoprotein cholesterol (LDL-c) levels and an increased risk of cardiovascular disease. Despite the use of high-dose statins and the recent addition of proprotein convertase subtilisin/kexin type 9 inhibitors as a treatment option, many patients with homozygous FH fail to achieve optimal reductions of LDL-c levels. Gene therapy has become one of the most promising research directions for contemporary life sciences and is a potential treatment option for FH...
June 13, 2018: Journal of Atherosclerosis and Thrombosis
Noriko Kameyama, Chizuko Maruyama, Fuyuha Kitagawa, Kazunobu Nishii, Kaori Uenomachi, Yayoi Katayama, Hiromi Koga, Naoko Chikamoto, Yuko Kuwata, Junko Torigoe, Masako Arimoto, Toshiaki Tokumaru, Katsunori Ikewaki, Atsushi Nohara, Yoshihiko Otsubo, Koji Yanagi, Masayuki Yoshida, Mariko Harada-Shiba
AIM: Lomitapide is an oral inhibitor of the microsomal triglyceride transfer protein used to treat homozygous familial hypercholesterolemia (HoFH); patients require a low-fat diet to minimize gastrointestinal adverse effects and dietary supplements to prevent nutrient deficiencies. We investigated the diet and nutritional status during lomitapide treatment. METHODS: Japanese patients with HoFH, who were in a phase 3 trial of lomitapide, were instructed to start low-fat diets with supplements of vitamin E and essential fatty acids 6 weeks before starting lomitapide treatment...
June 12, 2018: Journal of Atherosclerosis and Thrombosis
Yujiro Asada, Atsushi Yamashita, Yuichiro Sato, Kinta Hatakeyama
Ischemic cardiovascular disease is a major cause of morbidity and mortality worldwide and thrombus formation on disrupted atherosclerotic plaques is considered to trigger its onset. Although the activation of platelets and coagulation pathways has been investigated intensively, the mechanisms of thrombus formation on disrupted plaques have not been understood in detail. Platelets are thought to play a central role in the formation of arterial thrombus because of rapid flow conditions; however, thrombus that develops on disrupted plaques consistently includes large amounts of fibrin in addition to aggregated platelets...
June 9, 2018: Journal of Atherosclerosis and Thrombosis
Gang Li, Rui Hu, Yifang Guo, Lili He, Qingjuan Zuo, Yan Wang
AIMS: ST-segment elevation myocardial infarction (STEMI) is an acute inflammatory and thrombotic disease due to coronary artery atherosclerotic lesions. Studies have established the correlation of serum sulfatides with inflammation, thrombogenesis, and atherosclerosis. We observed that serum sulfatides level significantly increased in STEMI patients. In this study, we try to identify the relationship of serum sulfatides level on clinical outcomes of patients in STEMI. METHODS: Serum sulfatides level was monitored in 370 inpatients within 24 h of STEMI onset...
June 9, 2018: Journal of Atherosclerosis and Thrombosis
Yukiko Okami, Hirotsugu Ueshima, Yasuyuki Nakamura, Nagako Okuda, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saitoh, Akira Okayama, Katsushi Yoshita, Sohel R Choudhury, Queenie Chan, Paul Elliott, Jeremiah Stamler, Katsuyuki Miura
AIM: The positive relationship between dietary cholesterol and serum cholesterol has been questioned by a set of recent cohort studies. This study aimed to investigate how employment status and education years relate to the association between dietary cholesterol and serum low-density lipoprotein cholesterol (LDL-C) in a Japanese population. METHODS: A population-based, random sample, cross-sectional study (INTERLIPID) was performed. Among 1,145 Japanese individuals aged 40-59 years, 106 were excluded because of special diets, use of lipid-lowering drugs, hormone replacement, and missing data, leaving 1,039 individuals (533 men and 506 women)...
June 9, 2018: Journal of Atherosclerosis and Thrombosis
Mariko Harada-Shiba, Hidenori Arai, Yasushi Ishigaki, Shun Ishibashi, Tomonori Okamura, Masatsune Ogura, Kazushige Dobashi, Atsushi Nohara, Hideaki Bujo, Katsumi Miyauchi, Shizuya Yamashita, Koutaro Yokote
Statement1. Familial hypercholesterolemia (FH) is an autosomal hereditary disease with the 3 major clinical features of hyper-LDL-cholesterolemia, premature coronary artery disease and tendon and skin xanthomas. As there is a considerably high risk of coronary artery disease, in addition to early diagnosis and intensive treatment, family screening (cascade screening) is required (Recommendation level A)2.For a diagnosis of FH, at least 2 of the following criteria should be satisfied:① LDL-C ≥180 mg/dL, ② Tendon/skin xanthomas, ③ History of FH or premature coronary artery disease (CAD) within 2nd degree blood relatives (Recommendation level A)3...
June 7, 2018: Journal of Atherosclerosis and Thrombosis
Wei Sun, Guangsheng Li, Xiangjun Zeng, Zhaohui Lai, Mingqi Wang, Yi Ouyang, Guoyong Zeng, Jidong Peng, Junyuan Zhong, Daoxiong Xiao, Zhiping Huang, Xiaofen Guo
AIMS: Nonvalvular atrial fibrillation often occurs in combination with carotid atherosclerosis, but less is known about it in combination with cerebral artery stenosis. This study investigated the characteristics of cerebral infarction in patients with nonvalvular atrial fibrillation with or without cerebral artery stenosis. METHODS: A retrospective analysis was conducted on 172 cerebral infarction patients with nonvalvular atrial fibrillation hospitalized at the Affiliated Ganzhou Hospital of Nanchang University between December 2011 and January 2016...
June 5, 2018: Journal of Atherosclerosis and Thrombosis
Shinji Yokoyama
No abstract text is available yet for this article.
June 2, 2018: Journal of Atherosclerosis and Thrombosis
Kensaku Nishihira
No abstract text is available yet for this article.
May 24, 2018: Journal of Atherosclerosis and Thrombosis
Satoshi Kimura, Hirotsugu Noguchi, Uki Nanbu, Ke-Yong Wang, Yasuyuki Sasaguri, Toshiyuki Nakayama
AIM: CCL22, mainly synthesized by monocyte-derived alternative (M2) macrophages, belongs to the CC family of chemokines and is involved in monocyte migration and recruitment. We have previously investigated CCL22 and histamine in atherosclerosis. Here, we investigated the hypothesis that CCL22 is involved in atherosclerosis, which is influenced by the differentiation of macrophage phenotypes via histamine. METHODS: CCL22 expression was investigated in human carotid arteries and coronary arteries with bare metal stents...
May 22, 2018: Journal of Atherosclerosis and Thrombosis
Mizuki Yamanaka, Masae Sakuma, Asami Matsushita, Satomi Tanaka, Yuri Yamamoto, Toshihiko Asai, Hidekazu Arai
AIM: This study aimed to evaluate the effect of diet on serum lipids and to assess the effectiveness of long-term dietary therapy for hypertriglyceridemia. METHODS: Seventy-nine patients (34 males and 45 females) with hypertriglyceridemia were enrolled and underwent dietary counseling for 12 months based on the following three recommendations: (1) reduce carbohydrate intake, (2) increase n-3 polyunsaturated fatty acid (PUFA) intake, and (3) limit alcohol drinking...
May 22, 2018: Journal of Atherosclerosis and Thrombosis
Ippei Watanabe, Junko Tatebe, Takahiro Fujii, Ryota Noike, Daiga Saito, Hideki Koike, Takayuki Yabe, Ryo Okubo, Rine Nakanishi, Hideo Amano, Mikihito Toda, Takanori Ikeda, Toshisuke Morita
AIM: We investigated whether indoxyl sulfate (IS), a protein-bound uremic toxin, predicts prognosis after acute coronary syndrome (ACS). METHODS: Serum IS level was determined prospectively in 98 patients who underwent successful primary percutaneous coronary intervention for ACS. Patients on hemodialysis were excluded. The endpoint of this study was six-month composite events including death, nonfatal myocardial infarction, heart failure requiring hospitalization, and adverse bleeding events...
May 19, 2018: Journal of Atherosclerosis and Thrombosis
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