journal
MENU ▼
Read by QxMD icon Read
search

Journal of Atherosclerosis and Thrombosis

journal
https://www.readbyqxmd.com/read/29046488/principles-and-applications-of-rabbit-models-for-atherosclerosis-research
#1
Jianglin Fan, Yajie Chen, Haizhao Yan, Manabu Niimi, Yanli Wang, Jingyan Liang
Rabbits are one of the most used experimental animals for biomedical research, particularly as a bioreactor for the production of antibodies. However, many unique features of the rabbit have also made it as an excellent species for examining a number of aspects of human diseases such as atherosclerosis. Rabbits are phylogenetically closer to humans than rodents, in addition to their relatively proper size, tame disposition, and ease of use and maintenance in the laboratory facility. Due to their short life spans, short gestation periods, high numbers of progeny, low cost (compared with other large animals) and availability of genomics and proteomics, rabbits usually serve to bridge the gap between smaller rodents (mice and rats) and larger animals, such as dogs, pigs and monkeys, and play an important role in many translational research activities such as pre-clinical testing of drugs and diagnostic methods for patients...
October 19, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29046503/effects-of-a-novel-selective-peroxisome-proliferator-activated-receptor-%C3%AE-modulator-k-877-pemafibrate-on-postprandial-hyperlipidemia
#2
Yoshio Fujioka
No abstract text is available yet for this article.
October 18, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29046502/correlation-between-thyroid-stimulating-hormone-and-renal-function-in-euthyroid-residents-of-japan-results-from-the-kyushu-and-okinawa-population-study-kops
#3
Yuki Tanaka, Norihiro Furusyo, Yoshifumi Kato, Takatsugu Ueyama, Sho Yamasaki, Hiroaki Ikezaki, Masayuki Murata, Jun Hayashi
AIM: The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level and renal function. METHODS: Out of 1,374 residents who participated in a free public physical examination between 2010 and 2011, we evaluated the data of 888 participants for whom the serum TSH level and estimated glomerular filtration rate (eGFR) were successfully measured. The participants were categorized into three groups based on TSH levels (normal TSH, ≤2...
October 18, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28978867/cysteine-protease-cathepsins-in-atherosclerotic-cardiovascular-diseases
#4
Hongxian Wu, Qiuna Du, Qiuyan Dai, Junbo Ge, Xianwn Cheng
Atherosclerotic cardiovascular disease (ASCVD) is an inflammatory disease characterized by extensive arterial wall matrix protein degradation. Cysteine protease cathepsins play a pivotal role in extracellular matrix (ECM) remodeling and have been implicated in the development and progression of atherosclerosis-based cardiovascular diseases. An imbalance in expression between cathepsins (such as cathepsins S, K, L, C) and their inhibitor cystatin C may favor proteolysis of ECM in the pathogenesis of cardiovascular disease such as atherosclerosis, aneurysm formation, restenosis, and neovascularization...
October 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28978866/two-year-clinical-outcomes-post-implantation-of-epic-tm-self-expanding-nitinol-stents-for-the-aortoiliac-occlusive-disease-in-patients-with-peripheral-arterial-disease
#5
Takuya Tsujimura, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Shota Okuno, Yasuhiro Matsuda, Masahiko Fujihara, Yoshiaki Yokoi, Toshiaki Mano
AIM: We investigated 2-year clinical outcomes after implantaton of Epic(TM) self-expanding nitinol stents for patients with peripheral artery disease (PAD) due to the aortoiliac occlusive disease (AIOD). METHODS: This study was a multicenter and retrospective study. From February 2013 through October 2014, 292 lesions (chronic total occlusion, 21%; TASC Ⅱ C/D, 35%) in 217 consecutive patients (74±8 years; male, 81%; diabetes mellitus, 47%; dialysis, 21%; critical limb ischemia, 29%) who had undergone endovascular therapy (EVT) with Epic(TM) self-expanding nitinol stents for PAD with AIOD were analyzed...
October 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28966336/mechanism-of-development-of-atherosclerosis-and-cardiovascular-disease-in-diabetes-mellitus
#6
Naoto Katakami
Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes cerebro-cardiovascular diseases, which are major causes of death in patients with DM and significantly reduce their quality of life. The alterations in vascular homeostasis due to endothelial and vascular smooth muscle cell dysfunction are the main features of diabetic macroangiopathy. Although multiple metabolic abnormalities that characterize diabetes are involved in the progression of atherosclerosis in patients with DM, it may be said that prolonged exposure to hyperglycemia and insulin resistance clustering with other risk factors such as obesity, arterial hypertension, and dyslipidemia play crucial roles...
September 29, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28943527/crossing-bridges-between-extra-and-intra-cellular-events-in-thoracic-aortic-aneurysms
#7
Yoshito Yamashiro, Hiromi Yanagisawa
Thoracic aortic aneurysms (TAAs) are common, life-threatening diseases and are a major cause of mortality and morbidity. Over the past decade, genetic approaches have revealed that 1) activation of the transforming growth factor beta (TGF-β) signaling, 2) alterations in the contractile apparatus of vascular smooth muscle cells (SMCs), and 3) defects in the extracellular matrix (ECM) were responsible for development of TAAs. Most recently, a fourth mechanism has been proposed in that dysfunction of mechanosensing in the aortic wall in response to hemodynamic stress may be a key driver of TAAs...
September 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28931783/prediction-of-stroke-after-cardiac-catheterization-no-reason-no-stroke
#8
Atsushi Tanaka, Koichi Node
No abstract text is available yet for this article.
September 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28931782/tumor-necrosis-factor-%C3%AE-gene-expression-in-epicardial-adipose-tissue-is-related-to-coronary-atherosclerosis-assessed-by-computed-tomography
#9
Toshiro Kitagawa, Hideya Yamamoto, Takuya Hattori, Kazuhiro Sentani, Shinya Takahashi, Atsuhiro Senoo, Yumiko Kubo, Wataru Yasui, Taijiro Sueda, Yasuki Kihara
AIMS: Tumor necrosis factor (TNF)-α reportedly has key pro-inflammatory properties in both atherosclerosis and adipocytes. To further investigate the biologic impact of epicardial adipose tissue (EAT) on coronary atherosclerosis, we evaluated the relationship between TNF-α gene expression in EAT and clinically-assessed coronary atherosclerosis on computed tomography (CT). METHODS: We studied 47 patients before cardiac surgery (coronary artery bypass grafting [CABG], n=26; non-CABG, n=21), assessing visceral adipose tissue (VAT) area, EAT volume, coronary calcium score (CCS), and the presence of non- and/or partially-calcified coronary plaque (NCP) on CT angiography...
September 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28924103/pravastatin-reduces-the-risk-of-atherothrombotic-stroke-when-administered-within-six-months-of-an-initial-stroke-event
#10
Naohisa Hosomi, Yoji Nagai, Kazuo Kitagawa, Yoko Nakagawa, Shiro Aoki, Tomohisa Nezu, Tatsuo Kagimura, Hirofumi Maruyama, Hideki Origasa, Kazuo Minematsu, Shinichiro Uchiyama, Masayasu Matsumoto
AIMS: The J-STARS study examined whether pravastatin (10 mg/day) reduces recurrence of stroke in non-cardioembolic ischemic stroke patients who were enrolled within 1 month to 3 years after initial stroke events (ClinicalTrials.gov, NCT00221104). The main results showed that the frequency of atherothrombotic stroke was low in pravastatin-treated patients, although no effect of pravastatin was found for the other stroke subtypes. We evaluated differences of early (within 6 months) or late (after 6 months) pravastatin treatment benefits on the incidence of stroke or transient ischemic attack (TIA), as well as atherothrombotic stroke and the other subtypes...
September 16, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28904253/genetic-variants-of-ramp2-and-clr-are-associated-with-stroke
#11
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai
AIM: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions...
September 14, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28904249/relationship-between-serum-uric-acid-and-vascular-function-and-structure-markers-and-gender-difference-in-a-real-world-population-of-china-from-beijing-vascular-disease-patients-evaluation-study-best-study
#12
Huan Liu, Jinbo Liu, Hongwei Zhao, Yingyan Zhou, Lihong Li, Hongyu Wang
AIM: The study was done to establish the relationship between serum uric acid (UA) and vascular function and structure parameters including carotid femoral pulse wave velocity (CF-PWV), carotid radial pulse wave velocity (CR-PWV), cardio ankle vascular index (CAVI), ankle brachial index (ABI), and carotid intima-media thickness (CIMT), and the gender difference in a real-world population from China. METHODS: A total of 979 subjects were enrolled (aged 60.86±11...
September 12, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28867683/microrna-134-promotes-the-development-of-atherosclerosis-via-the-angptl4-lpl-pathway-in-apolipoprotein-e-knockout-mice
#13
Qiong Ye, Guo-Ping Tian, Hai-Peng Cheng, Xin Zhang, Xiang Ou, Xiao-Hua Yu, Ru-Qi Tan, Feng-Yun Yang, Duo Gong, Chong Huang, Yan-Jun Pan, Jie Zhang, Ling-Yan Chen, Zhen-Wang Zhao, Wei Xie, Liang Li, Min Zhang, Xiao-Dan Xia, Xi-Long Zheng, Chao-Ke Tang
AIMS: Atherosclerosis is the most common cause of cardiovascular disease, such as myocardial infarction and stroke. Previous study revealed that microRNA (miR)-134 promotes lipid accumulation and proinflammatory cytokine secretion through angiopoietin-like 4 (ANGPTL4)/lipid lipoprotein (LPL) signaling in THP-1 macrophages. METHODS: ApoE KO male mice on a C57BL/6 background were fed a high-fat/high-cholesterol Western diet, from 8 to 16 weeks of age. Mice were divided into four groups, and received a tail vein injection of miR-134 agomir, miR-134 antagomir, or one of the corresponding controls, respectively, once every 2 weeks after starting the Western diet...
September 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28855433/effects-of-cardiac-rehabilitation-on-high-density-lipoprotein-mediated-cholesterol-efflux-capacity-and-paraoxonase-1-activity-in-patients-with-acute-coronary-syndrome
#14
Fumiaki Furuyama, Shinji Koba, Yuya Yokota, Fumiyoshi Tsunoda, Makoto Shoji, Youichi Kobayashi
AIMS: We evaluated whether exercised-based cardiac rehabilitation (CR) can ameliorate the HDL function, i.e., cholesterol efflux capacity (CEC) and paraoxonase-1 activity in patients with acute coronary syndrome (ACS). METHODS: This study is a retrospective analysis of stored serum from patients with ACS following successful percutaneous coronary intervention. The CEC, measured by a cell-based ex vivo assay using apolipoprotein B-depleted serum and (3)H-cholesterol labeled macrophages and arylesterase activity (AREA) at the onset or early phase of ACS, and the follow-up periods were compared between 69 patients who completed the five-month outpatient CR program (CR group) and 15 patients who did not participate and/or dropped out from CR program (non-CR group)...
August 30, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28855432/prospective-study-on-the-incidence-of-cerebrovascular-disease-after-coronary-angiography
#15
Akihiro Tokushige, Masaaki Miyata, Takeshi Sonoda, Ippei Kosedo, Daisuke Kanda, Takuro Takumi, Yuichi Kumagae, Yoshihiko Fukukura, Mitsuru Ohishi
AIM: Previous studies have reported a 10.2%-22% rate of silent cerebral infarction and a 0.1%-1% rate of symptomatic cerebral infarction after coronary angiography (CAG). However, the risk factors of cerebral infarction after CAG have not been fully elucidated. For this reason, we investigated the incidence and risk factors of CVD complications within 48 h after CAG using magnetic resonance imaging (MRI) (Diffusion-weighted MRI) at Kagoshima University Hospital. METHODS: From September 2013 to April 2015, we examined the incidence and risk factors, including procedural data and patients characteristics, of cerebrovascular disease after CAG in consecutive 61 patients who underwent CAG and MRI in our hospital...
August 30, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28835581/carotid-artery-parameters-after-combined-exercise-training-in-women-with-sarcopenic-obesity
#16
Yuko Gando
No abstract text is available yet for this article.
August 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28835580/epoxyeicosatrienoic-acids-are-mediated-by-ephx2-variants-and-may-be-a-predictor-of-early-neurological-deterioration-in-acute-minor-ischemic-stroke
#17
Xingyang Yi, Jing Lin, Jie Li, Qiang Zhou, Zhao Han
AIM: To investigatethe association of plasma epoxyeicosatrienoic acids (EETs) with early neurologic deterioration (END), and whether EETs are mediated by EPHX2 variants in patients with minor ischemic stroke (MIS). METHOD: This was a prospective, multi-center observational study in patients with acute MIS in the Chinese population.Plasma EETs levels were measured on admission. Single nucleotide polymorphisms (SNPs) of EPHX2 rs751141 were genotyped using mass spectrometry...
August 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28835579/additional-value-of-brachial-ankle-pulse-wave-velocity-to-single-photon-emission-computed-tomography-in-the-diagnosis-of-coronary-artery-disease
#18
Kyeongmin Jang, Hack-Lyoung Kim, Miri Park, Sohee Oh, So Won Oh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim
AIM: The aim of this study was to investigate whether information on arterial stiffness can improve the value of single-photon emission computed tomography (SPECT) in the detection of obstructive coronary artery disease (CAD). METHODS: A total of 233 patients (age: 62.2±10.8 years, 60.3% males) with detected ischemia on SPECT undergoing invasive coronary angiography (ICA) and brachial-ankle pulse wave velocity (baPWV) measurement within a month was retrospectively reviewed...
August 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28824048/lower-level-of-low-density-lipoprotein-cholesterol-is-associated-with-a-higher-increase-in-the-fractional-flow-reserve-in-patients-with-fixed-dose-rosuvastatin
#19
Takehiro Hashikata, Taiki Tojo, Yusuke Muramatsu, Toshimitsu Sato, Ryota Kakizaki, Teruyoshi Nemoto, Kazuhiro Fujiyoshi, Sayaka Namba, Lisa Kitasato, Takuya Hashimoto, Ryo Kameda, Takao Shimohama, Minako Yamaoka-Tojo, Junya Ako
AIM: Fractional flow reserve (FFR) reflects on the diffuse atherosclerosis per coronary artery. It is unknown whether the statin therapy affects long term FFR after stenting. The aim of this study was to evaluate the long term FFR after stent implantation in patients who are intaking fixed-dose rosuvastatin. METHODS: A total of 22 patients with stable angina pectoris were enrolled. The values of FFR were measured before, immediately after, and 18 months after (follow-up day) the implantation of everolimus eluting stent (EES; Promus Element(TM) or Promus Element Plus(TM))...
August 19, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28819082/dysregulation-of-calpain-proteolytic-systems-underlies-degenerative-vascular-disorders
#20
Takuro Miyazaki, Akira Miyazaki
Chronic vascular diseases such as atherosclerosis, aneurysms, diabetic angiopathy/retinopathy as well as fibrotic and proliferative vascular diseases are generally complicated by the progression of degenerative insults, which are characterized by endothelial dysfunction, apoptotic/necrotic cell death in vascular/immune cells, remodeling of extracellular matrix or breakdown of elastic lamella. Increasing evidence suggests that dysfunctional calpain proteolytic systems and defective calpain protein metabolism in blood vessels contribute to degenerative disorders...
August 17, 2017: Journal of Atherosclerosis and Thrombosis
journal
journal
32231
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"