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Journal of Atherosclerosis and Thrombosis

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https://www.readbyqxmd.com/read/29238011/plaque-calcification-during-atherosclerosis-progression-and-regression
#1
Atsushi Shioi, Yuji Ikari
Plaque calcification develops by the inflammation-dependent mechanisms involved in progression and regression of atherosclerosis. Macrophages can undergo two distinct polarization states, that is, pro-inflammatory M1 phenotype in progression and anti-inflammatory M2 phenotype in regression. In plaque progression, predominant M1 macrophages promote the initial calcium deposition within the necrotic core of the lesions, called as microcalcification, through not only vesicle-mediated mineralization as the result of apoptosis of macrophages and vascular smooth muscle cells (VSMCs), but also VSMC differentiation into early phase osteoblasts...
December 12, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29238010/rationale-and-descriptive-analysis-of-specific-health-guidance-the-nationwide-lifestyle-intervention-program-targeting-metabolic-syndrome-in-japan
#2
Kazuyo Tsushita, Akiko S Hosler, Katsuyuki Miura, Yukiko Ito, Takashi Fukuda, Akihiko Kitamura, Kozo Tatara
AIM: All health insurers in Japan are mandated to provide Specific Health Checkups and Specific Health Guidance (SHG) focusing on metabolic syndrome (MetS) in middle-aged adults, beginning in 2008; intensive HG for individuals who have abdominal obesity and two or more additional MetS risk factors, and motivational HG for individuals with one risk factor. The aim of this study is to describe medium-term changes in health indexes for intensive and motivational HG groups using the National Database...
December 12, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29225326/noninvasive-coronary-plaque-imaging
#3
Teruo Noguchi, Kazuhiro Nakao, Yasuhide Asaumi, Yoshiaki Morita, Fumiyuki Otsuka, Yu Kataoka, Hayato Hosoda, Hiroyuki Miura, Tetsuya Fukuda, Satoshi Yasuda
Early identification of high-risk or vulnerable atherosclerotic plaques prone to rupture and performing preemptive therapy prior to catastrophic cardiovascular events are optimal goals of plaque imaging. Despite the advances in imaging modalities to identify vulnerable characteristics, the predictive value of the imaging techniques in the clinical setting is still developing. In this regard, reliable and high-sensitive imaging modalities identifying vulnerable plaque characters that may lead to future cardiovascular events will be useful...
December 9, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29225325/omentin-1-is-associated-with-carotid-plaque-instability-among-ischemic-stroke-patients
#4
Tian Xu, Peng Zuo, Lin Cao, Zhiwei Gao, Kaifu Ke
AIMS: Omentin-1 was proved to be associated with ischemic stroke clinical functional outcome. It also predicted carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetes patients. Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic stroke patients. METHODS: A total of 173 acute ischemic stroke patients were included in this study. Serum omentin-1 levels were assayed. Carotid ultrasound examinations were performed to evaluate the carotid plaque instability and stenosis degree...
December 9, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29225324/effects-of-cilnidipine-an-l-n-type-calcium-channel-blocker-on-carotid-atherosclerosis-in-japanese-post-stroke-hypertensive-patients-results-from-the-ca-attend-study
#5
Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Noriyuki Suzuki, Tsukasa Teshima, Hitoshi Sugii, Shinobu Nagahama, Yoshiki Kurose, Hirofumi Maruyama, Masayasu Matsumoto
AIMS: Although several antihypertensive agents reduced the carotid intima-media thickness (IMT), it remains unclear whether those agents affect the interadventitial diameter (IAD). We aimed to examine whether cilnidipine, an L/N-type calcium channel blocker, reduced the common carotid IMT or IAD in post-stroke hypertensive patients. METHODS: The common carotid IMT and IAD were measured at the start of cilnidipine treatment and 12 months from that. The changes in the mean max-IMT or IAD between baseline and the 12-month follow-up were evaluated and compared between the thick group (max-IMT ≥1...
December 9, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29225209/dapagliflozin-reduces-fat-mass-without-affecting-muscle-mass-in-type-2-diabetes
#6
Seigo Sugiyama, Hideaki Jinnouchi, Noboru Kurinami, Kunio Hieshima, Akira Yoshida, Katsunori Jinnouchi, Hiroyuki Nishimura, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Tomio Jinnouchi
AIM: Sodium-glucose co-transporter 2 inhibitor (SGLT2i) therapy has been demonstrated to improve glycemic control and reduce body weight and fat mass in type 2 diabetes mellitus (T2DM). Here, our aim was to investigate the effects of SGLT2i dapagliflozin-treatment on body muscle mass and muscle fat content in patients with T2DM. METHODS: We prospectively recruited uncontrolled (hemoglobin A1c [HbA1c] >7%) Japanese T2DM patients who had a body mass index (BMI) <35 kg/m2...
December 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29212987/association-of-coronary-artery-calcification-with-estimated-coronary-heart-disease-risk-from-prediction-models-in-a-community-based-sample-of-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#7
Akira Fujiyoshi, Hisatomi Arima, Sachiko Tanaka-Mizuno, Takahashi Hisamatsu, Sayaka Kadowaki, Aya Kadota, Maryam Zaid, Akira Sekikawa, Takashi Yamamoto, Minoru Horie, Katsuyuki Miura, Hirotsugu Ueshima
AIM: The clinical significance of coronary artery calcification (CAC) is not fully determined in general East Asian populations where background coronary heart disease (CHD) is less common than in USA/Western countries. We cross-sectionally assessed the association between CAC and estimated CHD risk as well as each major risk factor in general Japanese men. METHODS: Participants were 996 randomly selected Japanese men aged 40-79 y, free of stroke, myocardial infarction, or revascularization...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29212986/effect-of-pear1-genetic-variants-on-1-year-outcomes-in-chinese-patients-with-acute-myocardial-infarction-after-percutaneous-coronary-intervention
#8
Yi Yao, Xiao-Fang Tang, Chen He, Ying Song, Jing-Jing Xu, Xian-Min Meng, Bo Xu, Run-Lin Gao, Jin-Qing Yuan
AIMS: Platelet endothelial aggregation receptor-1 (PEAR1) is a platelet transmembrane protein that plays an important role on platelet aggregation. The aim of this study was to investigate whether PEAR1 genetic variations are associated with 1-year outcomes in Chinese patients with acute myocardial infarction after percutaneous coronary intervention. METHODS: A total of 647 consecutive Chinese patients with acute myocardial infarction that underwent percutaneous coronary intervention and that were exposed to standard dual antiplatelet therapy with aspirin and clopidogrel were enrolled in this study...
December 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29199202/the-influence-of-the-japanese-nationwide-cardiovascular-prevention-system-health-guidance-on-smoking-cessation-among-smokers-a-propensity-score-matching-analysis
#9
Koshi Nakamura, Makoto Watanabe, Nagako Okuda, Katsushi Yoshita, Mai Kabayama, Sayuki Torii, Toru Kuribayashi, Kazuyoshi Itai, Kei Kamide, Katsuyuki Miura, Akira Okayama
AIM: We investigated whether 2 types of personalized health guidance (repeated and single counseling) in the Japanese nationwide cardiovascular prevention system promoted smoking cessation among smokers. METHODS: The study included 47,745 Japanese smokers aged 40 to 74 years classified into 2 personalized health guidance schemes. After a 1-year follow-up, we compared the rates of smoking cessation between individuals who had received counseling ("supported") and those who had not received counseling ("unsupported")...
December 2, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29199201/effects-of-a-dipeptidyl-peptidase-4-inhibitor-sitagliptin-on-glycemic-control-and-lipoprotein-metabolism-in-patients-with-type-2-diabetes-mellitus-gloria-trial
#10
Daisaku Masuda, Takuya Kobayashi, Masami Sairyou, Hiroyuki Hanada, Tohru Ohama, Masahiro Koseki, Makoto Nishida, Norikazu Maeda, Shinji Kihara, Tatsuya Minami, Koji Yanagi, Yasushi Sakata, Shizuya Yamashita
AIM: The morbidity of cardiovascular disease in patients with type 2 diabetes mellitus (DM) deteriorates in combination with dyslipidemia. The accumulation of remnant lipoproteins in patients with fasting and postprandial hypertriglyceridemia is highly atherogenic. The current study investigated whether the dipeptidyl peptidase-4 inhibitor sitagliptin ameliorates dyslipidemia and hyperglycemia. METHODS: We enrolled 38 patients with type 2 DM (20 males and 18 females, 65...
December 2, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29199200/age-stratification-and-impact-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-to-arachidonic-acid-ratios-in-ischemic-stroke-patients
#11
Yuji Ueno, Ryota Tanaka, Kazuo Yamashiro, Nobukazu Miyamoto, Kenichiro Hira, Naohide Kurita, Mayu Sakurai, Takao Urabe, Kazunori Shimada, Tetsuro Miyazaki, Hiroyuki Daida, Nobutaka Hattori
AIM: We focused on the ratios of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to arachidonic acid (AA) and explored the significance of these ratios relative to clinical characteristics by age in ischemic stroke patients. METHODS: We enrolled patients with acute ischemic stroke who underwent radiological investigations and laboratory examinations, including measurement of serum EPA, DHA, and AA levels, and controls. Patients were classified according to age (<65, 65-74, and ≥ 75 years) and the tertile of EPA/AA and DHA/AA ratios, and clinical aspects were compared with these factors...
December 2, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29187694/efficacy-and-safety-of-pitavastatin-in-children-and-adolescents-with-familial-hypercholesterolemia-in-japan-and-europe
#12
Mariko Harada-Shiba, John J P Kastelein, G Kees Hovingh, Kausik K Ray, Akira Ohtake, Osamu Arisaka, Takao Ohta, Tomoo Okada, Hideki Suganami, Albert Wiegman
AIM: Children with Familial Hypercholesterolemia (FH) are widely prescribed statins, and it has been suggested that the effects of statins differ among ethnicities. We compared the efficacy and safety of pitavastatin in children and adolescents with FH in clinical trials conducted in Japan and Europe. METHODS: Low-density lipoprotein cholesterol (LDL-C) reductions, adjusted for confounding factors, and safety were compared between the studies in Japan and Europe...
November 29, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29176261/reduced-vitamin-d-receptor-on-circulating-endothelial-progenitor-cells-a-new-risk-factor-of-coronary-artery-diseases
#13
Sidi Ai, Zhiqing He, Ru Ding, Feng Wu, Zhigang Huang, Jiamei Wang, Shuaibo Huang, Xianliang Dai, Jiayou Zhang, Jing Chen, Linlin Liu, Zonggui Wu, Chun Liang
AIM: Endothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD). METHODS: Two hundred patients with CAD after their admission to hospital and one hundred healthy controls were enrolled...
November 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29162773/a-high-fat-and-high-cholesterol-diet-induces-cardiac-fibrosis-vascular-endothelial-and-left-ventricular-diastolic-dysfunction-in-shrsp5-dmcr-rats
#14
Shogo Watanabe, Shota Kumazaki, Katsuhiro Kusunoki, Terumi Inoue, Yui Maeda, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Shozo Kusachi, Kazuya Kitamori, Mari Mori, Yukio Yamori, Hisao Oka
AIM: Non-alcoholic steatohepatitis (NASH) increases cardiovascular risk regardless of risk factors in metabolic syndrome. However, the intermediary factors between NASH and vascular disease are still unknown because a suitable animal model has never been established. The stroke-prone (SP) spontaneously hypertensive rat, SHRSP5/Dmcr, simultaneously develops hypertension, acute arterial lipid deposits in mesenteric arteries, and NASH when feed with a high-fat and high-cholesterol (HFC) diet...
November 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29142179/usefulness-of-a-short-dietary-propensity-questionnaire-in-japan
#15
Nagako Okuda, Kazuyoshi Itai, Akira Okayama
AIM: There is a growing need for nutritional education for prevention and non-pharmacological treatment of risk factors for cardiovascular diseases (CVD). We compared the results of a short dietary propensity questionnaire (SDPQ) with those from the food frequency and quantity survey (FF Quantity), which had been previously quantitatively assessed by comparison with the 24-hr dietary recall (24hr-DR), to examine the usefulness of the SDPQ. The SDPQ was designed to assess dietary propensities of 12 food/nutrients relevant to CVD risk factors...
November 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29142155/modulation-of-high-density-lipoprotein-function-via-cardiac-rehabilitation
#16
Seimi Satomi-Kobayashi, Tatsuro Ishida
No abstract text is available yet for this article.
November 14, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29129854/update-on-the-therapeutic-strategy-of-type-b-aortic-dissection
#17
Shuichiro Kaji
Stanford type B aortic dissection (TBAD) is a life-threatening disease. Current therapeutic guidelines recommend medical therapy with aggressive blood pressure lowering for patients with acute TBAD unless they have fatal complications. Although patients with uncomplicated TBAD have relatively low early mortality, aorta-related adverse events during the chronic phase worsen the long-term clinical outcome. Recent advances in thoracic endovascular aortic repair (TEVAR) can improve clinical outcomes in patients with both complicated and uncomplicated TBAD...
November 10, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29118311/factors-associated-with-intima-media-complex-thickness-of-the-common-carotid-artery-in-japanese-noncardioembolic-stroke-patients-with-hyperlipidemia-the-j-stars-echo-study
#18
Shinichi Wada, Masatoshi Koga, Kazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai, Shiro Aoki, Tomohisa Nezu, Naohisa Hosomi, Tatsuo Kagimura, Hideki Origasa, Kenji Kamiyama, Rieko Suzuki, Toshiho Ohtsuki, Hirofumi Maruyama, Kazuo Kitagawa, Shinichiro Uchiyama, Masayasu Matsumoto
AIMS: There may be ethnic differences in carotid atherosclerosis and its contributing factors between Asian and other populations. The purpose of this study was to examine intima-media complex thickness (IMT) of the carotid artery and associated clinical factors in Japanese stroke patients with hyperlipidemia from a cohort of the Japan Statin Treatment Against Recurrent Stroke Echo Study. METHODS: Patients with hyperlipidemia, not on statins, who developed noncardioembolic ischemic stroke were included in this study...
November 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29118310/manifestation-of-coronary-atherosclerosis-in-klang-valley-malaysia-an-autopsy-study
#19
Razuin Rahimi, Mansharan Kaur Chainchel Singh, Norizal Mohd Noor, Effat Omar, Shahidan Md Noor, Mohd Shah Mahmood, Nurliza Abdullah, Hapizah Mohd Nawawi
AIMS: The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS: This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented...
November 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29093277/the-coronary-artery-running-pattern-is-one-of-the-causes-of-individual-differences-in-the-progression-of-coronary-atherosclerosis-in-whhlmi-rabbits-an-animal-model-for-coronary-atherosclerosis
#20
Ryosuke Nagasaka, Tomonari Koike, Norie Tsukada, Shohei Tamura, Masashi Shiomi
AIMS: The relationship between the coronary artery running pattern and development of coronary lesions was re-examined herein using WHHLMI rabbits, an animal model of spontaneous coronary atherosclerosis. METHODS: The coronary artery running pattern was analyzed using an X-ray computed tomography (CT) apparatus after perfusion. Pathological sections were prepared (Victoria blue-HE staining) at 100 µm intervals from the origin of the left circumflex artery (LCX)...
November 1, 2017: Journal of Atherosclerosis and Thrombosis
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