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Journal of Atherosclerosis and Thrombosis

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https://www.readbyqxmd.com/read/29445076/clinical-utility-of-carotid-ultrasonography-in-the-prediction-of-cardiovascular-events-in-patients-with-diabetes-a-combined-analysis-of-data-obtained-in-five-longitudinal-studies
#1
Naoto Katakami, Tomoya Mita, Masahiko Gosho, Mitsuyoshi Takahara, Yoko Irie, Tetsuyuki Yasuda, Taka-Aki Matsuoka, Takeshi Osonoi, Hirotaka Watada, Iichiro Shimomura
AIM: It remains unclear whether measures used in carotid ultrasonography such as the intima-media thickness (IMT) and ultrasonic tissue characterization of the carotid using the gray-scale median (GSM) can add prognostic information beyond the conventional cardiovascular risk markers in patients with diabetes. METHODS: This study employed a combined analysis of data obtained in five longitudinal studies including a total of 3263 patients with diabetes but without apparent cardiovascular disease (CVD) at baseline...
February 14, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29415955/associations-of-tobacco-smoking-with-impaired-endothelial-function-the-circulatory-risk-in-communities-study-circs
#2
Meishan Cui, Renzhe Cui, Keyang Liu, Jia-Yi Dong, Hironori Imano, Mina Hayama-Terada, Isao Muraki, Masahiko Kiyama, Takeo Okada, Akihiko Kitamura, Mitsumasa Umesawa, Kazumasa Yamagishi, Tetsuya Ohira, Hiroyasu Iso
AIMS: Smoking impairs endothelial function as an acute effect. However, few population-based studies have examined the association between smoking status and endothelial function or the dose-response and duration-response association of smoking with endothelial function. We examined whether smoking habits were associated with impaired endothelial function depending on smoking dose and duration. METHODS: We conducted a cross-sectional study of 910 men and women aged 30-79 years from 2013 to 2016...
February 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29415954/antiplatelet-therapy-in-acs-patients-comparing-appropriate-p2y12-inhibition-by-clopidogrel-to-the-use-of-new-p2y12-inhibitors
#3
Jessica Ristorto, Nathan Messas, Benjamin Marchandot, Marion Kibler, Sébastien Hess, Nicolas Meyer, Michael Schaeffer, Nicolas Tuzin, Patrick Ohlmann, Laurence Jesel, Olivier Morel
AIM: In percutaneous coronary intervention (PCI)-treated acute coronary syndrome (ACS) patients on clopidogrel therapy, high on-treatment platelet adenosine diphosphate (ADP) reactivity was observed in numerous studies, with significant increases in non-fatal myocardial infarction, definite/probable stent thrombosis, or cardiovascular mortality. Compared to clopidogrel, prasugrel and ticagrelor provide more potent platelet inhibition. Whether new P2Y12 inhibitors reduce thrombotic events in a similar manner compared to the rate observed with appropriate P2Y12 inhibition by clopidogrel must still be determined...
February 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29415908/cerebrorenal-interaction-and-stroke-outcome
#4
Masatoshi Koga
No abstract text is available yet for this article.
February 7, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29415907/guidance-for-pediatric-familial-hypercholesterolemia-2017
#5
Mariko Harada-Shiba, Takao Ohta, Akira Ohtake, Masatsune Ogura, Kazushige Dobashi, Atsushi Nohara, Shizuya Yamashita, Koutaro Yokote
This paper describes consensus statement by Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (FH) in order to improve prognosis of FH.FH is a common genetic disease caused by mutations in genes related to low density lipoprotein (LDL) receptor pathway. Because patients with FH have high LDL cholesterol (LDL-C) levels from the birth, atherosclerosis begins and develops during childhood which determines the prognosis...
February 6, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398681/double-face-of-vasohibin-1-for-the-maintenance-of-vascular-homeostasis-and-healthy-longevity
#6
Yasufumi Sato
The structural and functional integrity of endothelium is essential for the maintenance of vascular health. Vasohibin-1 (VASH1), originally isolated as an endothelium-derived angiogenesis inhibitor, has another function to promote stress tolerance of endothelial cells (ECs), and these functions are critical for the maintenance of vascular homeostasis preventing both pathological angiogenesis and stress-induced vascular diseases. The expression of VASH1 is downregulated during replicative senescence of ECs by the alteration of microRNA expression, and this age-associated downregulation of VASH1 might be a risk of deterioration of vascular homeostasis and age-related vascular diseases...
February 3, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398680/screening-validity-of-arterial-pressure-volume-index-and-arterial-velocity-pulse-index-for-preclinical-atherosclerosis-in-japanese-community-dwelling-adults-the-nagasaki-islands-study
#7
Hirotomo Yamanashi, Jun Koyamatsu, Mako Nagayoshi, Yuji Shimizu, Shin-Ya Kawashiri, Hideaki Kondo, Shoichi Fukui, Mami Tamai, Takahiro Maeda
AIM: The arterial pressure-volume index (API) and arterial velocity-pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults. METHODS: We conducted a cross-sectional study of 2,809 participants aged ≥40 years who underwent Japanese national medical check-ups from 2014 to 2016. Preclinical atherosclerosis was defined as a mean carotid intima-media thickness (CIMT) of ≥1...
February 3, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398679/azelnidipine-inhibits-the-differentiation-and-activation-of-thp-1-macrophages-through-the-l-type-calcium-channel
#8
Hiroshi Komoda, Aya Shiraki, Jun-Ichi Oyama, Toshiyuki Nishikido, Koichi Node
AIM: Recently, calcium channel blockers (CCBs) have been reported to reduce atherosclerosis with anti-inflammatory or antiatherosclerotic effects in vivo. It is well established that monocytes and macrophages play important roles in promoting atherosclerosis. However, the effects of CCBs on macrophage activation remain unclear. The aim of this study was to evaluate the effects of azelnidipine, a dihydropyridine L-type CCB, on the activation of macrophages and to clarify the mechanisms of the effects of CCBs on atherosclerosis...
February 3, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398677/trend-of-hdl-increase-among-japanese-people-continues-in-national-health-and-nutrition-survey
#9
Shinji Yokoyama
No abstract text is available yet for this article.
February 2, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398676/association-of-the-serum-endostatin-level-renal-function-and-carotid-atherosclerosis-of-healthy-residents-of-japan-results-from-the-kyushu-and-okinawa-population-study-kops
#10
Yoshifumi Kato, Norihiro Furusyo, Yuuki Tanaka, Sho Yamasaki, Takatsugu Ueyama, Koji Takayama, Fujiko Mitsumoto-Kaseida, Masayuki Murata, Hiroaki Ikezaki, Jun Hayashi
AIM: To analyze associations among the serum endostatin level, renal function, and carotid atherosclerosis of healthy residents of Japan. METHODS: Among 1,057 Japanese residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents (200 men and 448 women, age 24 to 84 years) for whom the serum endostatin level and common carotid intima-media thickness (IMT) were measured. Renal function was assessed by estimated glomerular filtration rate (eGFR)...
February 2, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29398675/the-novel-apolipoprotein-e-mutation-apoe-chengdu-c-518t%C3%AF-c-p-l173p-in-a-chinese-patient-with-lipoprotein-glomerulopathy
#11
Hongyan Wu, Yuan Yang, Zhangxue Hu
AIMS: Lipoprotein glomerulopathy (LPG) is a rare inherited renal disease. Several apolipoprotein E (apoE) mutations have been reported to be related to LPG. Herein, we report a case of a LPG patient with a novel apoE mutation. METHODS: A 45-year-old Chinese female was diagnosed as LPG by renal biopsy. APOE gene was sequenced. Clinical and genetic studies were conducted. RESULTS: The patient presented with nephrotic syndrome and hypertension...
February 2, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29386421/clinical-characteristics-of-nonobese-patients-with-acute-coronary-syndrome-and-increased-epicardial-fat-volume
#12
Ken Harada, Hitomi Suzuki, Shun Matsunaga, Tomohiro Onishi, Yoshinori Nishikawa, Hiroshi Funakubo, Kumiko Mamiya, Tomoyuki Nagao, Norihiro Shinoda, Shinichi Sakai, Masataka Kato, Nobuyuki Marui, Hideki Ishii, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
AIM: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV. METHODS: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal...
February 1, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29375084/what-does-commercial-database-tell-us-about-medical-sciences
#13
Shinji Yokoyama
No abstract text is available yet for this article.
January 26, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29375083/additive-prognostic-value-of-carotid-plaque-score-to-enhance-the-age-creatinine-and-ejection-fraction-score-in-patients-with-acute-coronary-syndrome
#14
Takuya Nakahashi, Hayato Tada, Kenji Sakata, Akihiro Nomura, Miho Ohira, Mika Mori, Masayuki Takamura, Kenshi Hayashi, Masakazu Yamagishi, Masa-Aki Kawashiri
AIM: To assess whether combining measurements obtained from carotid ultrasonography in addition to the age, creatinine, and ejection fraction (ACEF) score would improve the predictive ability of outcome in patients with acute coronary syndrome (ACS). METHODS: We examined 264 patients with ACS (194 men; mean age: 68±11 years) who underwent percutaneous coronary intervention. The carotid plaque score (cPS) and intima-media thickness (cIMT) were determined by carotid ultrasonography...
January 26, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29367522/low-plasma-levels-of-fibroblast-growth-factor-21-in-patients-with-peripheral-artery-disease
#15
Yoshichika Miyazaki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Toshiki Seki, Kotaro Miura, Norie Suzuki-Sugihara, Yukinori Ikegami, Reiko Ohmori, Kazuo Kondo, Yukihiko Momiyama
AIM: Fibroblast growth factor-21 (FGF-21) is a metabolic regulator with beneficial effects on glucolipid metabolism. Since FGF-21 has lipid-lowering, anti-inflammatory and anti-oxidant properties, it may play a protective role against atherosclerosis. However, blood FGF-21 levels in coronary artery disease (CAD) or peripheral artery disease (PAD) have not been elucidated. METHODS: We measured plasma FGF-21 levels in 417 patients undergoing coronary angiography, who also had ankle-brachial index test for PAD screening...
January 24, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29367521/clinical-outcomes-after-isolated-infrapopliteal-revascularization-in-hemodialysis-patients-with-critical-limb-ischemia-endovascular-therapy-versus-bypass-surgery
#16
Ryuta Ito, Yoshitaka Kumada, Hideki Ishii, Daisuke Kamoi, Takashi Sakakibara, Norio Umemoto, Hiroshi Takahashi, Toyoaki Murohara
AIM: To investigate the long-term clinical outcome of endovascular therapy (EVT) or bypass surgery in patients on hemodialysis (HD) with critical limb ischemia due to isolated infrapopliteal disease. METHODS: We enrolled 254 consecutive HD patients successfully undergoing infrapopliteal revascularization by EVT (126 patients) and bypass surgery (128 patients). They were followed up for five years. Amputation-free survival (AFS) and incidence of any re-intervention were evaluated...
January 23, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353827/oral-fat-tolerance-test-for-sitosterolemia-and-familial-hypercholesterolemia-a-study-protocol
#17
Akihiro Nomura, Hayato Tada, Atsushi Nohara, Masa-Aki Kawashiri, Masakazu Yamagishi
AIM: Sitosterolemia is an extremely rare, autosomal recessive disease characterized by high plasma cholesterols and plant sterols because of increased absorption of dietary cholesterols and sterols from the intestine, and decreased excretion from biliary tract. Previous study indicated that sitosterolemic patients might be vulnerable to post-prandial hyperlipidemia, including high remnant-like lipoprotein particles (RLP) level. Here we evaluate whether a loading dietary fat increases a post-prandial RLP cholesterol level in sitosterolemic patients compared to heterozygous familial hypercholesterolemic patients (FH)...
January 20, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353826/the-association-between-glomerular-filtration-rate-estimated-on-admission-and-acute-stroke-outcome-the-shiga-stroke-registry
#18
Aryandhito Widhi Nugroho, Hisatomi Arima, Itsuko Miyazawa, Takako Fujii, Naomi Miyamatsu, Yoshihisa Sugimoto, Satoru Nagata, Masaru Komori, Naoyuki Takashima, Yoshikuni Kita, Katsuyuki Miura, Kazuhiko Nozaki
AIM: Although renal dysfunction has been identified as a novel risk factor affecting stroke prognosis, few have analyzed the association within large-scale population-based setting, using wide-range estimated glomerular filtration rate (eGFR) category. We aimed to determine the association of admission eGFR with acute stroke outcomes using data from a registry established in Shiga Prefecture, Japan. METHODS: Following exclusion of patients younger than 18 years, with missing serum creatinine data, and with onset more than 7 days prior to admission, 2,813 acute stroke patients registered in the Shiga Stroke Registry year 2011 were included in the final analysis...
January 19, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29353825/treatment-patterns-and-lipid-profile-in-patients-with-familial-hypercholesterolemia-in-japan
#19
Tamio Teramoto, Takahito Kai, Asuka Ozaki, Bruce Crawford, Hidenori Arai, Shizuya Yamashita
AIM: To evaluate the epidemiology and real-world treatment patterns associated with lipid-modifying therapies (LMTs) among groups of Japanese patients with familial hypercholesterolemia (FH). METHODS: A retrospective observational study was conducted using an electronic hospital-based administrative claims database and electronic medical records. Patients with existing diagnosis of FH (FH-D) and patients with suspected FH (FH-S) defined by low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL were included, and medical records of hospitals across Japan were analyzed to assess the diagnostic status, management of LDL-C levels, and treatment patterns...
January 19, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29332863/lipid-parameters-are-independently-associated-with-cardio-ankle-vascular-index-cavi-in-healthy-japanese-subjects
#20
Daiji Nagayama, Yasuhiro Watanabe, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
AIM: To investigate the associations of conventional lipid parameters with arterial stiffness assessed by cardio-ankle vascular index (CAVI). METHODS: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1±12.5 years, body mass index (BMI) 22.9±3.4 kg/m2) who underwent health screening between 2004 and 2006 in Japan. RESULTS: Male subjects had significantly higher BMI, CAVI and triglycerides (TG), and lower high-density lipoprotein cholesterol (HDL-C) compared to female subjects...
January 12, 2018: Journal of Atherosclerosis and Thrombosis
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