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Experimental and Clinical Endocrinology & Diabetes

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https://www.readbyqxmd.com/read/30625508/selenoprotein-p-in-patients-with-nonalcoholic-fatty-liver-disease
#1
Stergios A Polyzos, Jannis Kountouras, Maria Mavrouli, Panagiotis Katsinelos, Michael Doulberis, Elpida Gavana, Leonidas Duntas
OBJECTIVE: Main aim of this study was to evaluate circulating selenoprotein P (SEPP) levels in patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) compared with healthy controls. METHODS: Thirty-one patients with biopsy-proven NAFLD (15 with SS, 10 with borderline NASH, 6 with definite NASH) and 27 matched controls without NAFLD were enrolled. Serum SEPP levels and liver function tests plus biochemical parameters were measured with ELISA and standard methods, respectively...
January 9, 2019: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30616241/long-term-treatment-with-empagliflozin-attenuates-renal-damage-in-obese-zucker-rat
#2
Nandini D P K Manne, Gautam Kumar Ginjupalli, Kevin M Rice, Ravikumar Arvapalli, Vincent A Graffeo, Venkata V K Bandarupalli, Eric R Blough
INTRODUCTION: Empagliflozin, a known inhibitor of sodium-glucose cotransporter type 2 (SGLT2) decreases glucose reabsorption by the renal tubules and promotes glucose excretion into the urine. While the effectiveness of Empagliflozin in the management of hyperglycemia along with associated cardiovascular and all-cause mortality has been demonstrated previously, the therapeutic benefits associated with the long-term use of this drug in obese animals have yet to be investigated. METHODS: Male 5-week-old lean and obese Zucker rats were randomly assigned to one of the 4 groups- lean control, lean treated, obese control, obese treated and treated with either Empagliflozin (10 mg/kg BW / day) or placebo for 25 weeks to investigate the therapeutic effect of Empagliflozin...
January 7, 2019: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30562826/depression-and-diabetic-peripheral-neuropathy-birds-of-a-feather-but-when-do-they-flock-together
#3
Prashanth R J Vas, Nikolaos Papanas
The association between diabetes and depression is well recognised. Similarly, diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes. Given the high prevalence of these conditions individually, it is hardly surprising they frequently interact, conferring additional morbidity and a higher mortality risk. Despite this, the specific clinical characteristics that underpin co-morbid depression and DPN remain unclear. Additionally, there is insufficient insight into causal pathways and temporal trends...
December 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30562825/higher-serum-uric-acid-is-a-risk-factor-of-vertebral-fractures-in-postmenopausal-women-with-type-2-diabetes-mellitus
#4
Ken-Ichiro Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
PURPOSE: Serum uric acid (UA) level may affect bone metabolism because it has an anti-oxidative effect. However, whether serum UA level is associated with a fracture risk in type 2 diabetes mellitus (T2DM) is unclear. We thus aimed to clarify the association between serum UA and bone parameters in T2DM. METHODS: We conducted a cross-sectional study to investigate the association of serum UA with bone mineral density (BMD) at lumbar spine (LS) and femoral neck (FN), bone turnover markers such as osteocalcin and urine type I collagen cross-linked N-telopeptide (uNTX), and the prevalence of vertebral fractures (VF) in 356 postmenopausal women and 512 men with T2DM...
December 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30562824/an-update-on-addison-s-disease
#5
Andreas Barthel, Georg Benker, Kai Berens, Sven Diederich, Burkhard Manfras, Matthias Gruber, Waldemar Kanczkowski, Greg Kline, Virginia Kamvissi-Lorenz, Stefanie Hahner, Felix Beuschlein, Ana Brennand, Bernhard O Boehm, David J Torpy, Stefan R Bornstein
Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced...
December 18, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30557892/adherence-to-therapeutic-footwear-in-type-2-diabetes-in-malta
#6
Cynthia Formosa, Anthea Borg, Nikolaos Papanas, Stephen Mizzi
BACKGROUND: The literature reports that people living with diabetes do not adhere to their prescribed therapeutic footwear as instructed. The reason for this is still uncertian although certain footwear characteristics seem to reasons reported leading to reduced level of adherence. OBJECTIVES: To explore the reasons for current adherence or otherwise to prescribed stock footwear amongst patients living with type-2 diabetes. METHODS: An exploratory qualitative design method using an Interpretative Phenomenological Analysis [IPA] was employed in this research...
December 17, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30557891/peripheral-insulin-extraction-in-non-diabetic-subjects-and-type-2-diabetes-mellitus-patients
#7
Daniël H van Raalte, Eva van der Palen, Pauline Idema, Liza Wong, Sander W M Keet, Mariska Vlot, Raymond Tukkie, Bob van Vlies, Erik H Serné, Reinier W Ten Kate
BACKGROUND: Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients. METHODS: Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Thirty-six participants were studied in the fasted state (22 ND subjects and 14 T2D patients termed NDF and T2DF) and 34 participants 1-h following a glucose challenge (18 ND subjects and 16 T2D patients indicated as NDG and T2DG)...
December 17, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30541167/higher-serum-uric-acid-is-a-risk-factor-of-reduced-muscle-mass-in-men-with-type-2-diabetes-mellitus
#8
Ken-Ichiro Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
OBJECTIVE: Sarcopenia has been recognized as a diabetic complication, and hyperuricemia is often accompanied by type 2 diabetes mellitus (T2DM). However, it is unknown whether serum uric acid (UA) levels are associated with reduced muscle mass in T2DM. METHODS: We conducted a cross-sectional study to investigate the association of serum UA with muscle mass in 401 subjects with T2DM (209 men and 192 postmenopausal women). The relative skeletal muscle mass index (RSMI) was evaluated using whole-body dual-energy x-ray absorptiometry...
December 12, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30536266/reduced-fat-oxidation-during-exercise-in-post-menopausal-overweight-obese-women-with-higher-lipid-accumulation-product-index
#9
Elana Stein, Igor Martins Silva, Gilson P Dorneles, Fabio Santos Lira, Pedro Romão, Alessandra Peres
BACKGROUND AND AIMS: The main aim of this study was to analyze how the lipid accumulation affects the whole-body fat oxidation over a range of intensities during a submaximal incremental exercise test in post-menopausal overweight-obese women. PATIENTS AND METHODS: The maximal fat oxidation (MFO), the intensity where the MFO occurs (FatMax), fat oxidation were measured over a range of intensities during a submaximal incremental exercise test through indirect calorimetry in 60 postmenopausal overweight-obese women (aged>49 years; body mass index 28...
December 10, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30536265/metabolomic-analysis-of-diet-induced-obese-mice-supplemented-with-eicosapentaenoic-acid
#10
Shigeki Nishitani, Atsunori Fukuhara, Yasutaka Jinno, Hiroyuki Kawano, Takashi Yano, Michio Otsuki, Iichiro Shimomura
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with anti-inflammatory effects. To determine the effects of EPA on metabolic pathways in obese adipose tissues and liver, mice were fed normal chow diet (NCD), high-fat diet (HFD), or 3% EPA-containing high fat diet (HFD+EPA) for 8 weeks. Metabolomic analysis was performed using epididymal adipose tissues (epi WAT) and liver. Metabolites that were specifically elevated in HFD+EPA, were assessed for their anti-inflammatory properties using RAW264.7 macrophage cells...
December 10, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30508848/gestational-diabetes-mellitus-in-a-tertiary-care-hospital-of-kolkata-india-prevalence-pathogenesis-and-potential-disease-biomarkers
#11
Jayita Basu, Chhanda Datta, Subhankar Chowdhury, Debasmita Mandal, Nandan Kumar Mondal, Amlan Ghosh
AIMS: Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence of GDM among pregnant women visiting antenatal clinic of a tertiary-care hospital of Kolkata, India; possible mechanism of disease pathogenesis and potency of associated parameters as disease biomarkers were also explored. METHODS: 735 pregnant women were screened for GDM according to DIPSI (Diabetes in Pregnancy Study Group India) guideline and risk-factors were analyzed...
December 3, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30497083/use-of-metformin-and-platelet-reactivity-in-diabetic-patients-treated-with-dual-antiplatelet-therapy
#12
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Claudia Ceccon, Marina Caputo, Gianluca Aimaretti, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Enhanced platelet reactivity represents one of the major determinants of cardiovascular risk among diabetic patients. The aim of the present study was to evaluate the impact of metformin use on platelet reactivity in diabetic patients receiving dual antiplatelet therapy (DAPT). METHODS: We included diabetic patients treated with DAPT after an acute coronary syndrome or percutaneous coronary intervention. Platelet reactivity was assessed at 30-90 days by Multiple-electrode aggregometry...
November 29, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30477037/development-of-the-metabolic-syndrome-study-design-and-baseline-data-of-the-lufthansa-prevention-study-lups-a-prospective-observational-cohort-survey
#13
Dirk Müller-Wieland, Christiane Altenburg, Heiko Becher, Janine Burchard, Anett Frisch, Jan Gebhard, Jutta Haas, Volker Harth, Jörg Heeren, Johannes Hengelbrock, Maximilian von Karais, Birgit Knebel, Jörg Kotzka, Bernd Löwe, Nikolaus Marx, Hans Pinnschmidt, Alexandra Preisser, Matthias Rose, Barbara Sawitzky-Rose, Ludger Scheja, Claudia Terschüren, Monika Töller, Eik Vettorazzi, Karl Wegscheider
The Lufthansa Prevention Study (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25-60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history...
November 26, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30469158/advanced-adrenocortical-carcinoma-what-to-do-when-first-line-therapy-fails
#14
Felix Megerle, Matthias Kroiss, Stefanie Hahner, Martin Fassnacht
Adrenocortical carcinoma is a rare endocrine malignant disease with a generally unfavorable but heterogeneous prognosis. Although even in advanced stages a subset of patients experiences long-term disease stabilisation, effective systemic treatment options are limited. Mitotane is the only approved drug and the combination of etoposide, doxorubicin and cisplatin (plus mitotane) is currently considered as treatment standard for advanced adrenocortical carcinoma based on the results of a large randomized phase III trial...
November 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30469157/biomarkers-in-non-complicated-pregnancy-insights-about-serum-myeloperoxidase-and-ultrasensitive-c-reactive-protein
#15
Danielle C Kalva-Borato, Josilaine Tonin Ribas, Gisele Chibinski Parabocz, Luciana Maria Borba, Margarete Aparecida Salina Maciel, Fabio André Dos Santos, José Carlos Rebuglio Vellosa
INTRODUCTION: Pregnancy is characterized by increased innate immune response, with low-grade systemic inflammation. The specific role of MPO during normal pregnancy remains not well understood. Therefore, the aim of this study was to evaluate plasma levels of MPO, hs-CRP, total leukocyte, absolute neutrophil and monocyte counts, in all trimesters of normal human pregnancy compared with non-pregnant controls. In addition, possible fluctuations of MPO according to different inflammatory conditions in the normal gestation were studied...
November 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30458553/gastroesophageal-reflux-in-asymptomatic-patients-with-diabetes-an-impedance-study-diabetes-obesity-and-gastroesophageal-reflux
#16
Suut Gokturk, Filiz Akyuz, Serpil Arici, Busra Alpaslan, Asli Ormeci, Ozlem Mutluay Soyer, Sami Evirgen, Bilger Cavus, Ayse Kubat Uzum, Nurdan Gul, Umit Akyuz, Cetin Karaca, Kadir Demir, Sabahattin Kaymakoglu, Ilhan Satman, Fatih Besisik
INTRODUCTION: Gastroesophageal reflux disease (GERD) is more frequent in patients with diabetes mellitus (DM).The aim of the present study was to evaluate GER in asymptomatic patients with DM using 24-h pH impedance. MATERIALS AND METHODS: 19 healthy controls and 35 patients with DM without typical GERD symptoms were enrolled in the study. A 24-h pH-impedance study, esophageal manometry and gastroscopy were performed on all patients with DM. In the control group, an impedance study was performed on all subjects, and gastroscopy and esophageal manometry were performed on those who consented to the procedures...
November 20, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30453342/comparison-of-the-effects-of-prophylactic-and-therapeutic-administrations-on-peripheral-neuropathy-in-streptozotocin-diabetic-rats-with-gliclazide-or-methylcobalamin
#17
Hongping Yao, Juanyi Feng, Qiaowei Zheng, Youxia Wei, Guangde Yang, Weiyi Feng
OBJECTIVE: To observe the differences in curative effects between prophylactic and therapeutic administrations of Gliclazide (GLZ) or Methylcobalamin (MCA) on diabetic peripheral neuropathy in rats. METHODS: GLZ (25 mg/kg/day) or MCA (175 μg/kg/day) was orally administrated prophylactically to streptozotocin-induced diabetic rats for 8 weeks before diabetic peripheral neuropathy developed or administrated therapeutically after diabetic peripheral neuropathy developed, respectively...
November 19, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30428497/carney-complex
#18
Crystal D C Kamilaris, Fabio Rueda Faucz, Antonis Voutetakis, Constantine A Stratakis
Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the PRKAR1A gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of PRKAR1A lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Endocrine manifestations include primary pigmented nodular adrenocortical disease, that may cause Cushing syndrome, growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia which can result in acromegaly, as well as gonadal and thyroid tumors...
November 14, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30428496/hypoglycemia-and-glucagon-utilization-in-insulin-treated-diabetic-patients
#19
Marino Vilovic, Tina Ticinovic Kurir, Anela Novak, Mladen Krnic, Josip Andelo Borovac, Ivan-Kresimir Lizatovic, Visnja Kokic, Josko Bozic
BACKGROUND: First choice of therapy for severe hypoglycemia outside hospital environment is glucagon injection, an undertaught and underused remedy. Aim of this study was to investigate knowledge about glucagon therapy, possession rate and usage rate in insulin-treated diabetic patients, with special emphasis on history of hypoglycemia and severe hypoglycemia episodes. METHODS: In this cross-sectional study, 300 insulin-treated diabetic patients (146 males and 154 females, mean age 61...
November 14, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/30428495/treatment-of-refractory-adrenocortical-carcinoma-with-thalidomide-analysis-of-27-patients-from-the-european-network-for-the-study-of-adrenal-tumours-registry
#20
Matthias Kroiss, Timo Deutschbein, Wiebke Schlötelburg, Cristina Lucia Ronchi, Ségolène Hescot, Daniela Körbl, Felix Megerle, Felix Beuschlein, Bruno Neu, Marcus Quinkler, Eric Baudin, Stefanie Hahner, Anke Heidemeier, Martin Fassnacht
OBJECTIVE: Adrenocortical carcinoma (ACC) is a rare malignancy with a dismal prognosis. In advanced stages, tumour control by mitotane and cytotoxic chemotherapy is often temporary and salvage treatments are warranted. METHODS: Retrospective cohort study of participants in the prospective European Networks for the Study of Adrenal Tumours (ENSAT) registry. Main outcome measures were best response during treatment, progression-free survival (PFS), both measured according to RECIST 1...
November 14, 2018: Experimental and Clinical Endocrinology & Diabetes
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