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Experimental and Clinical Endocrinology & Diabetes

Xin Zhao, Xiao-Mei Zhang, Ning Yuan, Xiao-Feng Yu, Li-Nong Ji
OBJECTIVE: To identify correlations of bone mineral density (BMD) and bone metabolism indices with the urine albumin to creatinine ratio (ACR) as an indicator of nephropathy in Chinese patients with type 2 diabetes (T2D). METHODS: In this retrospective analysis, 297 patients with T2D were divided into 3 groups according to the urine ACR. Patients' data were analyzed to identify associations of general conditions, blood glucose level, lipid levels, and uric acid level with BMD and bone metabolism indices...
November 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Susanne Neschen, Moya Wu, Christiane Fuchs, Ivan Kondofersky, Fabian J Theis, Martin Hrabě de Angelis, Hans-Ulrich Häring, Tina Sartorius
AIMS AND METHODS: Glucose homeostasis and energy balance are under control by peripheral and brain processes. Especially insulin signaling in the brain seems to impact whole body glucose homeostasis and interacts with fatty acid signaling. In humans circulating saturated fatty acids are negatively associated with brain insulin action while animal studies suggest both positive and negative interactions of fatty acids and insulin brain action. This apparent discrepancy might reflect a difference between acute and chronic fatty acid signaling...
November 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Jian Li, Nan Li, Shuangtong Yan, Minyan Liu, Banruo Sun, Yanhui Lu, Yinghong Shao
BACKGROUND: Age-related bone deteriorations are the common endocrine disorders in the elderly population, leading to an increased risk of fractures. Therefore, effective treatment strategies provide a way to prevent bone loss and improve the quality of life in the elderly population. The present study aimed to investigate the anti-osteoporotic effects of doxercalciferol (DOX) in aging mice. METHODS: Bone metabolism-related markers were measured by ELISA assay. The expression of bone formation and resorption-related genes was performed by RT-qPCR analysis...
October 31, 2018: Experimental and Clinical Endocrinology & Diabetes
Guido Di Dalmazi
Patients with adrenal incidentalomas and autonomous cortisol secretion (ACS) have been recognized as a category at risk of developing cardiovascular and metabolic co-morbidities. Considering the increasing number of patients affected by this condition, it is important to perform an accurate subtyping of the patients, in the light of a tailored treatment. This review aims to identify the phenotypic characteristics of patients with adrenal incidentalomas and ACS who are at risk of developing severe cortisol-related co-morbidities...
October 29, 2018: Experimental and Clinical Endocrinology & Diabetes
Xinwei Chen, Lijing Huo, Luping Ren, Yali Li, Yanmei Sun, Yang Li, Pu Zhang, Shuchun Chen, Guang-Yao Song
PURPOSE: Periostin is a secreted extracellular matrix protein that is strongly associated with triglyceride metabolism, chronic inflammation, and insulin resistance. Growing evidence suggests that there is a link between periostin and ovarian function. Our aim was to ascertain whether circulating periostin levels are altered in women with polycystic ovary syndrome (PCOS) and to further explore the relationship between periostin and glucose metabolism disorder in PCOS patients. METHODS: In total, 50 women with PCOS and 30 age-matched controls without PCOS were recruited for this cross-sectional study...
October 29, 2018: Experimental and Clinical Endocrinology & Diabetes
Soon Sung Kwon, Sang-Guk Lee
AIMS: Early identification of individuals with insulin resistance (IR) and metabolically unhealthy state can help prevent various diseases and improve quality of life. In this study, we investigated a possible marker of IR and metabolic health status, alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio, and aimed to confirm its feasibility in a large population study. METHODS: A total of 16,371 adults from Korean National Health and Examination Survey were studied...
October 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Andreas Holstein, Ulf Titze, Cornelius Hess
It has been estimated that 15% up to one third of cases of deaths due to diabetic ketoacidosis occur in individuals with so far unknown diabetes. Moreover, cardiac arrhythmias that occur during nocturnal hypoglycaemia include bradycardia and ectopics that may provoke lethal arrhythmias. As postmortem capillary glucose concentrations have no diagnostic value, the postmortem forensic proof of hyperglycaemia or hypoglycaemia remains a challenge. The established but rarely applied method of postmortem determination of glucose and lactate in vitreous humor with or without calculation of the sum formula of Traub could provide reliable exclusion or proof of severe antemortem disorders in glucose metabolism...
October 19, 2018: Experimental and Clinical Endocrinology & Diabetes
Katharina Warncke, Sebastian Kummer, Peter Herbert Kann, Dominik Bergis, Esther Bollow, Michael Hummel, Flavius Zoicas, Sebastian Wernert, Reinhard W Holl
BACKGROUND: Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. METHODS: Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9...
October 17, 2018: Experimental and Clinical Endocrinology & Diabetes
Toktam Razavi, Shideh Montasser Kouhsari, Khalil Abnous
Diabetes mellitus is a complex metabolic disease around the world that is characterized by hyperglycemia resulting from impaired insulin secretion, insulin action, or both. MicroRNA-29a is an important regulator of insulin signaling and gluconeogenesis pathways through IRS2 , PI3K and PEPCK expressions which up regulates in Diabetes. Morin is a substantial bioflavonoid which has insulin mimetic effect, and interacting with nucleic acids and proteins. In this study HepG2 cells, were exposed to high glucose to induce diabetic condition...
October 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Marie Méan, Gérard Waeber, Pedro Marques-Vidal
BACKGROUND: One in five hospitalized patients presents with previously undetected diabetes mellitus (DM). We assessed whether hospital doctors measure HbA1 c in hospitalized patients and act consequently. METHODS: Data from patients hospitalized between January 2013 and December 2014 in a Swiss teaching hospital was collected. We assessed the frequency of HbA1c measurements and the number of newly detected prediabetes or DM. We also examined whether HbA1c values were associated with the antidiabetic drugs prescription and reporting of DM in the discharge letter...
October 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Marie Auzanneau, Barbara Bohn, Ralf Schiel, Rainer Stachow, Sibylle Koch, Thomas Hermann, Reinhard W Holl
INTRODUCTION: In Germany, inpatient rehabilitation is a well-established additive option in the therapeutic concept for children and adolescents with diabetes. However, its contribution in pediatric diabetes care is not known exactly. Our objective was to analyze inpatient rehabilitation in pediatric diabetes over eight years in Germany. METHODS: We requested secondary data from the German Statutory Pension Insurance Scheme to evaluate all completed inpatient rehabilitations for children and adolescents with diabetes (ICD-code E10-14) reimbursed by this institution between 2006 and 2013...
October 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Muge Bilge, Aylia Yesilova, Mine Adas, Aysen Helvaci
BACKGROUND: Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in HT remains unclear. OBJECTIVES: The aim of this study was to investigate the relationship between thyroid autommunity and NLR and PLR as markers of systemic inflammation in HT. METHODS: In this study, we evaluated 145 women with HT and 60 age-matched healthy controls...
September 28, 2018: Experimental and Clinical Endocrinology & Diabetes
Maria Zafeiri, Constantinos Tsioutis, Zoe Kleinaki, Philip Manolopoulos, Ioannis Ioannidis, George Dimitriadis
OBJECTIVES: Both diabetic peripheral neuropathy and depression have significant implications on patients' quality of life, management and outcomes. We aimed to evaluate all available evidence concerning patients with co-existent diabetic peripheral neuropathy and depression, and describe their clinical characteristics, in order to promote early recognition and management. METHODS: Systematic search of PubMed for studies providing data on patients with diabetic peripheral neuropathy and depression...
September 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Yingmin Wang, Weifen Zhu, Lianhui Chen, Li Liang
BACKGROUND: Small for gestational age (SGA) due to intrauterine malnourishment is closely related to metabolic syndrome and type 2 diabetes mellitus. Growth Hormone (GH) treatment has been demonstrated to influence metabolic parameters and islet function of SGA individuals. The present study demonstrates the effects of early GH treatment on glucose tolerance and expression of pancreatic duodenal homeobox 1 (Pdx1) of SGA rats during adulthood METHODS: SGA rat model was induced by restricting food intake during pregnancy...
September 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Deng Luo, Xiaolin Chen, Wenqiang Yang, Wenzhuo Ran, Zhongyuan Wen
Angiopoietin-like 8 (ANGPTL8) is closely linked to obesity-associated metabolic diseases and insulin resistance. The aim of the current study was to investigate the ability of ANGPTL8 to reverse insulin resistance in obese mice. The administration of ANGPTL8 reduced weight gain and improved glucose tolerance in mice with diet-induced obesity. In addition, ANGPTL8 administration modified macrophage infiltration, reduced monocyte chemoattractant protein-1 (MCP-1) and interleukin-1β(IL-1β) levels, and increased adiponectin gene expression in inguinal white adipose tissue (iWAT)...
September 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Karim Gariani, Michael Egloff, Sarah Prati, Jacques Philippe, Michel Boulvain, François R Jornayvaz
AIMS: To evaluate if the adoption of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) diagnostic criteria for Gestational Diabetes Mellitus (GDM) led to changes in the management and in the occurrence of pregnancy complications. METHODS: This was a retrospective study of women with GDM followed at a single university center, diagnosed in 2009-2010 using the Carpenter and Coustan criteria (period 1) and in 2012-2013 using the IADPSG criteria (period 2)...
September 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Svenja Nölting, Ashley Grossman, Karel Pacak
Phaeochromocytomas (PCC) and paragangliomas (PGL) are rare tumours arising from the chromaffin cells of the adrenal medulla (PCC) or the paraganglia located outside the adrenal gland (PGL). However, their incidence is likely to be underestimated; around 10% of all PCC/PGL are metastatic, with higher metastatic potential of PGLs compared to PCCs. If benign, surgery is the treatment of choice, but if metastatic, therapy is challenging. Here we review the currently existing therapy options for metastatic PCCs/PGLs including conventional chemotherapy (the original Averbuch scheme, but updated), radiopharmaceutical treatments (131 I-MIBG, 90 Y- and 177 Lu-DOTATATE) and novel targeted therapies (anti-angiogenic tyrosine kinase inhibitors and mTORC1 inhibitors), emphasising future therapeutic approaches (HIF-2α and PARP inhibitors, temozolomide alone, metronomic temozolomide, somatostatin analogues) based on the oncogenic signalling pathways related to three different clusters comprising more than 20 well-characterised PCC/PGL susceptibility genes...
September 20, 2018: Experimental and Clinical Endocrinology & Diabetes
Yujie Wu, Xuenong Xing, Shandong Ye, Chao Chen, Jumei Wang
OBJECTIVE: Osteoporosis is a systemic skeletal disorder characterizedby reduced bone mass, deteriorated bone structure. Various studies have tried to evaluate the association between lipid level and osteoporosis, but the results were proved to be controversial. The objectives of this study are to assess the correlation between BMD and serum lipid levels, to determine independent variables associated with osteoporosis and osteopenia in men and postmenopausal women with type 2 diabetes (T2D)...
September 20, 2018: Experimental and Clinical Endocrinology & Diabetes
Songsong Lu, Rui Kang, Yongchao Wang, Mengjie Zhu, Lei Zhao, Qinzhu Xu, Ying Song, Chen Liu
OBJECTIVE: The goal of this study was to clarify the changes and clinical significance of thromboelastography (TEG) parameters in papillary thyroid carcinomas and nodular goiters. METHODS: 62 nodular goiter (NG) patients and 53 papillary thyroid carcinoma (PTC) patients were included. Coagulation indicators, together with a series of TEG parameters were collected and analyzed, compared with results of 61 healthy controls (HC). Correlation analysis was conducted between routine coagulation indicators and TEG parameters...
September 20, 2018: Experimental and Clinical Endocrinology & Diabetes
Izumi Hiratsuka, Hiroya Yamada, Mitsuyasu Itoh, Megumi Shibata, Takeshi Takayanagi, Masaki Makino, Yoshihisa Sugimura, Nobuki Hayakawa, Shuji Hashimoto, Atsushi Suzuki
OBJECTIVE: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition that can affect almost any organ. We investigated the association between IgG4-RD and the main characteristics of Graves' disease (GD) at the time of diagnosis. Additionally, we evaluated whether serum IgG4 levels change during treatment. DESIGN AND PATIENTS: Twenty-eight patients with newly diagnosed GD were enrolled into this longitudinal follow-up study. Serum IgG4 levels and thyroid function were measured in all the participants at the time of diagnosis...
September 20, 2018: Experimental and Clinical Endocrinology & Diabetes
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