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Experimental and Clinical Endocrinology & Diabetes

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https://www.readbyqxmd.com/read/28750433/effect-of-a-12-week-aerobic-exercise-training-on-serum-fetuin-a-and-adipocytokine-levels-in-type-2-diabetes
#1
Ling-Yun Zhang, Tao Liu, Ya-Qin Teng, Xiao-Yan Yao, Tian-Tian Zhao, Liang-Yan Lin, Qing-Song Jin, Yong-Jun Jin
Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors. Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week)...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750432/hyperthyroidism-in-patients-with-graves-ophthalmopathy-and-thyroidal-skeletal-and-eye-muscle-specific-type-2-deiodinase-enzyme-activities
#2
Ildikó Molnár, József A Szentmiklósi, Éva Somogyiné-Vári
Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T3 levels than T4 due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with (125)I-T4 substrate, while thyroid hormone and antibody levels with immunoassays.In Graves' ophthalmopathy, sera with elevated FT4 or FT3 levels reduced DII activites remarkably in all tissue fractions...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750431/nitric-oxide-plasma-level-as-a-barometer-of-endothelial-dysfunction-in-factory-workers
#3
Seiko Miyata, Akiko Noda, Yuki Hara, Jun Ueyama, Kiyoyuki Kitaichi, Takaaki Kondo, Yasuo Koike
Objective Nitric oxide (NO) plays a key role in the regulation of vascular tone and is known as one of the key markers of endothelial dysfunction. We investigated the relationship between NO and risk factors of lifestyle-related disease in factory workers. Methods Our study included 877 factory workers presenting hypertension, dyslipidemia and type 2 diabetes. oxidated forms of NO, NO2-/NO3- (NOx) plasma concentrations were measured using a colorimetric method. Results NOx plasma levels in patients with lifestyle-related disease were significantly lower than those in the controls...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750430/prevalence-and-distribution-of-diabetes-mellitus-in-a-maximum-care-hospital-urgent-need-for-hba1c-screening
#4
Johannes Kufeldt, Marketa Kovarova, Michael Adolph, Harald Staiger, Michael Bamberg, Hans-Ulrich Häring, Andreas Fritsche, Andreas Peter
Objective Diabetes mellitus affects almost one in 10 individuals in Germany. So far, little is known about the diabetes prevalence in maximum care hospitals. We assessed the diabetes prevalence, proportion of undiagnosed cases, the effectiveness of diabetes screening in a university hospital, the consequences for hospital stay and acquired complications. Research Design and Methods Over a 4 week period we determined HbA1c from 3 733 adult patients which were hospitalized at the university hospital of Tuebingen and had an available blood sample...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750429/self-reported-hypoglycaemic-events-in-2%C3%A2-430-patients-with-insulin-treated-diabetes-in-the-german-sub-population-of-the-hat-study
#5
Werner Kern, Andreas Holstein, Christian Moenninghoff, Joachim Kienhöfer, Matthias Riedl, Bernhard Kulzer
Data concerning true hypoglycaemic incidence in insulin-treated patients with diabetes in real-world clinical practice are lacking in Germany. The aim of this analysis was to determine the incidence of hypoglycaemia experienced by the German cohort of patients enrolled in the global Hypoglycaemia Assessment Tool (HAT) study. This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient diaries assessing patients aged ≥18 years in Germany, with type 1 diabetes (T1D) (n=811) or type 2 diabetes (T2D) (n=1 619) treated with insulin for >12 months...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750428/experiences-in-sensor-augmented-pump-therapy-in-families-with-two-children-with-type-1-diabetes-a-qualitative-study
#6
Franziska Bomba, Esther Müller-Godeffroy, Simone von Sengbusch
Background Caring for a child with type 1 diabetes is a tremendous challenge for a family. The aim of the study was to explore the experiences of transition to sensor-augmented pump therapy (SAP) in families with 2 affected children and the internal and external conditions which potentially impede or facilitate the adjustment process. Methods 5 families (9 parents, 8 children and adolescents) who used the SAP technology for 6 months were interviewed to describe their experiences. The interviews were analysed using thematic content analysis...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750427/environmental-risk-factors-for-type-1-diabetes-mellitus-development
#7
Boljat Antonela, Gunjača Ivana, Konstantinović Ivan, Vidan Nikolina, Boraska Perica Vesna, Pehlić Marina, Škrabić Veselin, Zemunik Tatijana
Background Although environmental factors induce development of type 1 diabetes mellitus (T1DM) in genetically susceptible individuals, many of those factors have been uncovered. Therefore, the aim of the present study was to analyze associations of T1DM with a wide range of environmental factors. Material and Methods A case-control study was conducted on 249 diabetic and 255 healthy individuals from the Dalmatian region of South Croatia. Data regarding risk factors during pregnancy and early life period of the child were evaluated...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704858/comparison-of-hba1c-measurements-using-3-methods-in-75-patients-referred-to-one-outpatient-department
#8
Johannes Roth, Nicolle Müller, Thomas Lehmann, Klas Böer, Sven Löbel, Joachim Pum, Ulrich Alfons Müller
Objective HbA1c is the most important surrogate parameter to assess the quality of diabetes care and is also used for the diagnosis of diabetes mellitus (DM) since 2010. We investigated the comparability of 3 HbA1c methods in the city of Jena (Germany). Methods The HbA1c determination was carried out in 50 healthy subjects and 24 people with DM (age 51.2±16.3 years, HbA1c 6.8±2.2%) with 3 different hemoglobin A1c testing methods at 4 locations in one city. Our laboratory (HPLC method) served as a reference for comparing the results...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704857/the-real-life-effectiveness-and-care-patterns-of-type-2-diabetes-management-in-greece
#9
Emmanuel Pagkalos, Anastasia Thanopoulou, Christos Sampanis, Stavros Bousboulas, Andreas Melidonis, Nicholas Tentolouris, Theodoros Alexandrides, Ilias Migdalis, Eugenia Karamousouli, Nikolaos Papanas
Aim To investigate the prevalence of hypoglycaemia during sulfonylurea (SU) treatment of type 2 diabetes mellitus (T2DM) in Greece and its influence on glycaemic control, treatment adherence and quality of life (QoL). Patients and methods This was a retrospective cross-sectional study. We included 383 T2DM patients ≥30 years old on treatment with SU in monotherapy or in combination with metformin for at least 6 months. Patients were requested to fill in retrospective questionnaires on hypoglycaemia experience, adherence, weight gain and lifestyle/behavioural factors along with QoL (EQ-5D-3L), treatment satisfaction (TSQM), and fear of hypoglycaemia (HFS-II Worry scale)...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704856/effects-of-highly-pure-enriched-cellulose-diet-on-digestibility-lipid-metabolism-and-redox-status-in-obese-offspring-of-streptozotocin-induced-diabetic-rats
#10
Bensalah Meryem, Bouanane Samira, Benyagoub Ouahiba, Merzouk Hafida, Baba Ahmed Fatima Zohra
The long-term nutritional efficacy of a highly-pure-enriched-cellulose (HPEC) diet and its effects on lipid metabolism and oxidant/antioxidant status were investigated in obese offspring of streptozotocin-induced diabetic rats. Diabetes in pregnant rats was induced by intraperitoneal injection of streptozotocin on day 5 of gestation. Control pregnant rats were injected with citrate buffer. At weaning offspring of diabetic and control rats were fed HPEC or control diet, they were housed individually in metabolic cage for 2 months to investigate the nutritional efficacy of the diets...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704855/reduction-of-hba1c-and-diabetes-related-distress-after-intervention-in-a-diabetes-day-care-clinic-in-people-with-type-2-diabetes-but-not-with-type-1-diabetes
#11
Nadine Kuniss, Ulrich Alfons Müller, Christof Kloos, Gunter Wolf, Guido Kramer
Objective The aim of this prospective, longitudinal study was to assess diabetes-related distress in people with diabetes mellitus type 1 (DM1) and type 2 (DM2) treated for diabetes-related problems and to evaluate, whether distress by diabetes are reduced after intervention in a diabetes day care clinic (DDC). Methods Diabetes-related burden was assessed with the "Problem Area In Diabetes" (PAID) questionnaire before (T0), directly after (T1) and 6 months after intervention (T2) in the DDC in 72 people (18 DM1, 54 DM2) admitted with a diabetes-specific problem to a DDC in a University department for metabolic diseases...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704854/switching-from-premixed-insulin-to-basal-insulin-analogue-for-type-2-diabetes-and-role-of-dipeptidyl-peptidase-4-inhibitors
#12
Fernando Gómez-Peralta, Cristina Abreu, Gustavo Mora-Navarro, Pilar López-Morandeira, Esteban Pérez-Gutierrez, Blanca Cordero-García, Miguel Brito-Sanfiel
Introduction This study aimed to confirm the usefulness of basal insulin analogue plus oral antidiabetic drugs (OADs) for type 2 diabetes (T2D) patients inadequately controlled with premixed insulin with/without OADs and assess the role of dipeptidyl peptidase-4 (DPP-4) inhibitors within this regimen in clinical practice. Methods Spanish retrospective observational study that included 186 T2D patients with glycosylated hemoglobin (HbA1c) >7% (53 mmol/mol) despite premixed insulin with/without OADs who had been switched to basal insulin analogue plus OADs...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704853/rbp4-lp-pla2-netrin-1-signaling-regulation-of-cognitive-dysfunction-in-diabetic-nephropathy-complicated-with-silent-cerebral-infarction
#13
Danyan Chen, Xiaolong Huang, Song Lu, Huacong Deng, Hua Gan, Xiaogang Du, Tang Weixue
Aim To investigate the RBP4/Lp-PLA2/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). Methods One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA2 and Netrin-1 were determined by Western Blot...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28704852/pregnancy-and-tumor-outcomes-in-women-with-prolactinoma
#14
Bárbara Araujo, Sandra Belo, Davide Carvalho
Context Management of prolactinomas during pregnancy has always been a challenge. There is a concern about the risk of tumor growth, as well as the effects of the treatment on the developing fetus. Another issue that has been less studied is the outcome of women with prolactinoma after pregnancy and lactation. Objectives To evaluate remission of hyperprolactinaemia after pregnancy and lactation in women with prolactinoma. To describe the safety of dopamine agonists for the fetus and pregnancy outcomes. Methods A retrospective study of 32 pregnancies in women with prolactinoma was conducted in a single-centre...
July 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28675915/risk-factors-for-premature-death-in-diabetes-patients-who-undergo-amputations-below-ankle-level
#15
Therese E Wilbek, Rasmus B Jansen, Bo Jørgensen, Ole Lander Svendsen
Aim To identify risk factors for early death in diabetes patients who undergo amputations below the ankle. Methods A retrospective study, where all hospital records of all diabetes patients who had undergone minimum one amputation below the ankle at the CWHC Bispebjerg Hospital, Denmark, in the period 1996-2013, were examined. The amputations were mainly trans-metatarsal amputations and partial amputations of toes. The participants were found via ICD10-codes. The included patients were followed from their first contact to the last registered contact...
July 4, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28675914/plasmatic-and-intracellular-markers-of-oxidative-stress-in-normal-weight-and-obese-patients-with-polycystic-ovary-syndrome
#16
Chantal Di Segni, Andrea Silvestrini, Romana Fato, Christian Bergamini, Francesco Guidi, Sebastiano Raimondo, Elisabetta Meucci, Daniela Romualdi, Rosanna Apa, Antonio Lanzone, Antonio Mancini
Introduction Insulin resistance (IR) is associated with polycystic ovary syndrome (PCOS). Oxidative stress (OS) is, in turn, related to IR. Studies in PCOS evidenced an increase in OS markers, but they are mainly performed in obese patients, while the complex picture of normal weight PCOS is still poorly investigated. Matherials and Methods To investigate OS in PCOS and relationship with hormonal and metabolic picture, we performed a case-control study in 2 PCOS groups: normal weight (N-PCOS, n=21, age 18-25 ys, mean±SEM BMI 20...
July 4, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28724170/circulating-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-predict-three-months-outcome-after-ischemic-stroke
#17
Moritz Armbrust, Hans Worthmann, Reinhard Dengler, Helmut Schumacher, Ralf Lichtinghagen, Christoph Cyrill Eschenfelder, Matthias Endres, Martin Ebinger
Reports on neuroprotective effects of Insulin-like growth factor-1 (IGF-1) and Insulin-like growth factor binding protein-3 (IGFBP-3) in ischemic brain tissue are inconsistent. The aim of this study was to determine if plasma levels of IGF-1 and IGFBP-3 in acute stroke patients are indicative of 3 months functional outcome. Plasma levels were measured via chemiluminescence immunoassay in heparin blood samples of patients included in the EARLY trial (NCT00562588). Plasma samples were drawn on admission and 8 days post-stroke...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28724169/the-spectrum-of-vitamin-d-deficiency-description-of-a-family
#18
Francesco Vierucci, Marta Del Pistoia, Emioli Randazzo, Francesco Massart, Giovanni Federico
Background Vitamin D deficiency represents a global health problem, affecting children and adolescents worldwide. Objects To confirm that vitamin D deficiency can present as a spectrum of clinical pictures. Methods We diagnosed nutritional rickets in a 10-month-old infant of Senegal origin with several risk factors for vitamin D deficiency. As many of these factors affected also his cohabitant relatives, we evaluate infant's family members (mother and 4 brothers) looking for other vitamin D deficiency-related comorbidities...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28724168/efficacy-and-safety-of-glp-1-receptor-agonists-across-the-spectrum-of-type-2-diabetes-mellitus
#19
Lawrence A Leiter, Michael A Nauck
For patients with type 2 diabetes mellitus, glucagon-like peptide-1 receptor agonists (GLP-1RAs) generally exert robust glucose-lowering effects that are at least as effective as insulin. As monotherapies, changes from baseline in HbA1c with GLP-1RAs ranged from -1.9 to -0.7% in phase 3 trials. In addition, GLP-1RAs confer a low risk of hypoglycaemia and have a body-weight advantage (changes from baseline ranging from -4.0 to -0.4 kg). There is also evidence of significant reductions in risk for cardiovascular events with some of these agents, with a number of other trials underway...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28445896/total-serum-antioxidant-capacity-in-healthy-normal-weight-and-asymptomatic-overweight-adults
#20
Ana Petelin, Paola Tedeschi, Annalisa Maietti, Mihaela Jurdana, Vincenzo Brandolini, Zala Jenko Pražnikar
Obesity and overweight are major contributors to the burden of chronic disease. Both are defined as abnormal or excessive fat accumulation and by increased production of free radicals leading to oxidative stress. The aim of the present study was to evaluate whether overweight and fat accumulation is associated with serum total antioxidant capacity (TAC) in men and women, irrespective of nutritional habits, nutrient intakes, physical activity, smoking, and other confounders, which may be responsible for modifying the association between serum TAC and overweight/obesity measures...
July 2017: Experimental and Clinical Endocrinology & Diabetes
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