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Experimental and Clinical Endocrinology & Diabetes

Ja Hye Kim, Go Hun Seo, Gu-Hwan Kim, Juyoung Huh, Il Tae Hwang, Ja-Hyun Jang, Han-Wook Yoo, Jin-Ho Choi
BACKGROUND: Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is classified either as Kallmann syndrome (KS) with anosmia or normosmic idiopathic hypogonadotropic hypogonadism (nIHH) and caused by mutations in more than 30 different genes. Recent advances in next-generation sequencing technologies have revolutionized the identification of causative genes by using massively parallel sequencing of multiple samples. This study was performed to establish the genetic etiology of IGD using a targeted gene panel sequencing of 69 known human IGD genes...
September 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Michaela Katja Stangl, Wolfgang Böcker, Vladimir Chubanov, Uta Ferrari, Michael Fischereder, Thomas Gudermann, Eric Hesse, Peter Meinke, Martin Reincke, Nicole Reisch, Maximilian M Saller, Jochen Seissler, Ralf Schmidmaier, Benedikt Schoser, Cornelia Then, Barbara Thorand, Michael Drey
Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance...
September 10, 2018: Experimental and Clinical Endocrinology & Diabetes
Luis Gustavo Perez-Rivas, Tracy Ann Williams, Martin Reincke
Primary aldosteronism is a common cause of endocrine hypertension. It results from the excess production of aldosterone by the adrenal cortex and is related to increased morbidity and mortality. Most cases of PA are sporadic but inherited patterns of the disease have been reported in the literature. Four forms of familial hyperaldosteronism (FH-I- FH-IV) are currently recognized, and the genetic basis has been clarified in recent years. In FH-I patients, aldosterone excess is produced by a CYP11B1/CYP11B2 fusion gene and it is suppressed by glucocorticoid treatment...
September 10, 2018: Experimental and Clinical Endocrinology & Diabetes
Hua Pan, Dan Yan, Mingtong Xu, Feng Li, Meng Ren, Jin Zhang, Muchao Wu
BACKGROUND: Increased blood lactate or uric acid (UA) levels are associated with an increased risk of metabolic syndrome (MS). The aim of this study was to investigate the effect of an interactive association between blood lactate and UA levels on MS. METHODS: This community-based cross-sectional study included 2584 Chinese subjects aged ≥ 18 years. Participants were classified into 3 groups based on lactate or UA level tertiles or into 9 groups based on a combination of lactate and UA level tertiles...
September 10, 2018: Experimental and Clinical Endocrinology & Diabetes
Antonela Boljat, Ivana Gunjača, Ivan Konstantinović, Nikolina Vidan, Vesna Boraska Perica, Marina Pehlić, Veselin Škrabić, Tatijana Zemunik
No abstract text is available yet for this article.
August 31, 2018: Experimental and Clinical Endocrinology & Diabetes
Katharina Schilbach, Riia Karoliina Junnila, Martin Bidlingmaier
Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has been shown to be a valuable screening test for identification of patients suffering from PA. Since the introduction of a more widespread ARR screening the number of PA patients significantly increased worldwide. Interpretation of ARR might be challenging: Several factors from posture to interfering drugs affect the ARR and need to be taken into account when collecting samples...
August 30, 2018: Experimental and Clinical Endocrinology & Diabetes
David Slezák, Otto Mayer, Jan Bruthans, Jitka Seidlerová, Martina Rychecká, Julius Gelžinský, Markéta Mateřánková, Petra Karnosová, Peter Wohlfahrt, Renata Cífková, Jan Filipovský
OBJECTIVES: Impaired glucose metabolism represents one the most important cardiovascular risk factors, with steeply raising prevalence in overall population. We aimed to compare mortality risk of impaired fasting glycaemia (IFG) and overt diabetes mellitus (DM) in patients with coronary heart disease (CHD). STUDY DESIGN: prospective cohort study METHODS: A total of 1685 patients, 6-24 months after myocardial infarction and/or coronary revascularization at baseline, were followed in a prospective cohort study...
August 29, 2018: Experimental and Clinical Endocrinology & Diabetes
Rainer Lundershausen, Sabrina Müller, Mahmoud Hashim, Joachim Kienhöfer, Stefan Kipper, Thomas Wilke
PURPOSE: To assess quality of life, glycemic control, and safety/tolerability associated with liraglutide versus insulin initiation in patients with type 2 diabetes in Germany. METHODS: Liraglutide/insulin-naïve adults with type 2 diabetes and inadequate glycemic control despite using oral antidiabetic medication were assigned to liraglutide (≤1.8 mg daily; n=878) or any insulin (n=382) according to the treating physician's decision and followed for 52 weeks...
August 29, 2018: Experimental and Clinical Endocrinology & Diabetes
Graciela Delgado, Marcus E Kleber, Bernhard K Krämer, Michael Morcos, Per M Humpert, Kerstin Wiegand, Andy Mauldin, Klaus Kusterer, Michael Enghöfer, Winfried März, Thomas Segiet, Alexander Lammert
BACKGROUND: In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. METHODS: The study was a randomized, open label crossover dietary intervention study with consecutive inclusion of 15 patients with uncontrolled type 2 diabetes...
August 29, 2018: Experimental and Clinical Endocrinology & Diabetes
Małgorzata Dobrzycka, Piotr Spychalski, Andrzej J Łachiński, Paulina Kobiela, Piotr Jędrusik, Jarek Kobiela
OBJECTIVES: Statins act by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase and are an important drug class in the treatment of lipid disorders. They lower cholesterol levels and modulate cardiovascular disease risk in both primary and secondary prevention. In addition, some studies have shown that statins may have an effect on colorectal cancer development and treatment. Our objective is to summarize published studies on the effect of statins on colorectal carcinogenesis. METHODS: A systematic review of the PubMed and Cochrane databases was performed to identify studies published between April 2010 and April 2018 that investigated the association between statin use and colorectal cancer incidence, mortality, and treatment...
August 27, 2018: Experimental and Clinical Endocrinology & Diabetes
Alejandra M Ramírez-Rodríguez, Manuel González-Ortiz, Esperanza Martínez-Abundis
AIM: To evaluate the effect of dapagliflozin on insulin secretion and insulin sensitivity in patients with prediabetes. METHODS: A randomized, double-blind, placebo-controlled clinical trial was carried out in 24 adults diagnosed with prediabetes and without pharmacological treatment. Patients were randomly assigned into two groups of 12 patients each to receive 10 mg of oral dapagliflozin or placebo once a day during 12 weeks. At baseline and at the end of the study, anthropometric and metabolic measurements were evaluated, including the first phase of insulin secretion, total insulin secretion, and insulin sensitivity...
August 27, 2018: Experimental and Clinical Endocrinology & Diabetes
Laila Ben Lamine, Amira Turki, Ghada Al-Khateeb, Nejla Sellami, Hagger B Amor, Sameh Sarray, Mohamed Jailani, Mohamed Ghorbel, Touhami Mahjoub, Wassim Y Almawi
BACKGROUND: To investigate the relationship between changes in circulating soluble CD40 ligand (sCD40L) levels and the presence and severity of type 2 diabetic retinopathy (DR). SUBJECTS AND METHODS: sCD40L plasma concentrations were measured in 205 type 2 diabetes (T2DM) patients without DR (DWR; n=50) and with DR (n=155), the latter subdivided into non-proliferative diabetic retinopathy [NPDR; n=98 (63.2%)], or proliferative retinopathy [PDR; n=57 (36.8%)] patients...
August 27, 2018: Experimental and Clinical Endocrinology & Diabetes
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Both vitamin D preparations and high-dose statin therapy were found to reduce thyroid antibody titers. OBJECTIVE: The purpose of this study was to assess whether vitamin D status determines the effect of statin therapy on thyroid autoimmunity. METHODS: The study population consisted of 39 euthyroid women with Hashimoto's thyroiditis and moderate or moderately high cardiovascular risk divided into two groups: women with vitamin D deficiency or insufficiency (group A; n=19) and women with normal vitamin D status (group B, n=20)...
August 27, 2018: Experimental and Clinical Endocrinology & Diabetes
Martin Röhling, Dominik Pesta, Daniel F Markgraf, Klaus Strassburger, Birgit Knebel, Volker Burkart, Julia Szendroedi, Karsten Müssig, Michael Roden
AIMS: Impaired lung function associates with deterioration of glycemic control and diabetes-related oxidative stress in long-standing type 2 diabetes. We hypothesized that recent-onset type 2 diabetes patients exhibit abnormal pulmonary function when compared to glucose-tolerant controls and that the frequencies of single-nucleotide polymorphisms (SNPs), known to associate with lung dysfunction, are different between both groups. METHODS: Type 2 diabetes patients with a known disease duration<1 year (n=34) had similar age, sex distribution and BMI as overweight controls (n=26)...
August 24, 2018: Experimental and Clinical Endocrinology & Diabetes
Hilmi Erdem Sumbul, Ayse Selcan Koc
No abstract text is available yet for this article.
August 22, 2018: Experimental and Clinical Endocrinology & Diabetes
Abdallah Al-Salameh, Sophie Bucher, Bernard Bauduceau, Linda Benattar-Zibi, Gilles Berrut, Philippe Bertin, Emmanuelle Corruble, Nicolas Danchin, Geneviève Derumeaux, Jean Doucet, Bruno Falissard, Françoise Forette, Olivier Hanon, Rissane Ourabah, Florence Pasquier, Michel Pinget, Laurent Becquemont, Virginie Ringa
AIMS: The main aim of the present work was to assess if sex influences the occurrence of major clinical events in elderly people with type 2 diabetes followed up in the primary care. METHODS: 983 subjects aged ≥65years with type 2 diabetes were included by 213 general practitioners and followed up prospectively for three years. Major clinical events were recorded every six month. The first endpoint was a composite of all-cause death and major vascular events (acute coronary syndrome, non-fatal stroke or transient ischemic attack, or revascularization for peripheral artery disease)...
August 22, 2018: Experimental and Clinical Endocrinology & Diabetes
Günter K Stalla, Denis Ciato, Christina Dimopoulou
BACKGROUND: Despite advances in diagnostic and therapeutic approach, Cushing's disease (CD) presents a challenging situation for the treating physician. AIMS: To elucidate current challenges, present strengths and pitfalls of existing diagnostic tests, enlighten the need for new diagnostic approaches, appraise the effects of surgery and available pharmacological agents and identify future perspectives regarding CD. MATERIALS AND METHODS: Systematic search to PubMed and Medline databases for publications mainly over the last five years...
August 21, 2018: Experimental and Clinical Endocrinology & Diabetes
Yuhong Yang, Martin Reincke, Tracy Ann Williams
The importance of an early diagnosis and appropriate management of patients with primary aldosteronism (PA) has become increasingly clear because of the adverse impact of the disorder on cardiovascular and cerebrovascular events and target organ damage. Adrenalectomy potentially cures patients with unilateral PA resulting in normalisation of blood pressure or significant clinical improvements in the majority of patients. Different criteria have been used to evaluate outcomes of unilateral adrenalectomy. Clinical remission (cure of hypertension) is observed in 6% to 86% of patients and clinical benefits from surgery are seen in the majority...
August 21, 2018: Experimental and Clinical Endocrinology & Diabetes
Ulrich J Knappe, Dag Moskopp, Rüdiger Gerlach, Jens Conrad, Jörg Flitsch, Jürgen B Honegger
BACKGROUND: Guidelines for patient behavior following transsphenoidal surgery do not exist. To gain generally recommendations, the German pituitary working group conducted a study among pituitary surgeons to elucidate their opinions and customs of patients' counselling. METHODS: Questions concerning daily activities, exertion of sports and work life were addressed. It was asked to provide the postoperative time interval after which specific activities can be resumed both after a routine or an extended approach...
August 21, 2018: Experimental and Clinical Endocrinology & Diabetes
Britta Wilms, Rahel Keppler, Barbara Ernst, Sebastian M Schmid, Martin Thurnheer, Bernd Schultes
BACKGROUND: Even subjects with severe obesity show a wide range of metabolic health states, with some showing marked alterations in glucose and lipid metabolism whereas others do not. In severely obese women, we could recently show that the degree of cardiorespiratory fitness is, independently of body mass and age, associated with several markers of glucose and lipid metabolism. AIMS: In our retrospective study on a clinical data set, we questioned whether such an association also exists in severely obese men...
August 17, 2018: Experimental and Clinical Endocrinology & Diabetes
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