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Experimental and Clinical Endocrinology & Diabetes

Di Zhao, Na-Sui Wang, Fu Chen, Zheng-Bing Li, Xi-Tao Li, Xu-Xin Zhu
BACKGROUND: miR-34a is a multifunctional post-translational modulator, which is involved in several diabetes-related complications. However, miR-34a remains to be fully elucidated in the diabetic endothelium from rats. In this study, the role of miR-34a/NOTCH1 signaling in the progression of hyperglycemia-vascular endothelial dysfunction was investigated. METHODS: In intravenous injection of miR-34a mimics and inhibitors in streptozotocin (STZ)-induced diabetic rats, the biomarkers of endothelial dysfunction was measured...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Martha Lappas, Harry M Georgiou, Anida Velagic, Jane C Willcox, Michael Permezel, Alexis Shub
AIMS: The risk of developing type 2 diabetes is greater in women with previous gestational diabetes mellitus (GDM). Apolipoprotein (Apo) species have been associated with the development of type 2 diabetes in the general population. The aim of this study was to determine if circulating levels of Apo species can predict development of type 2 diabetes in women with previous GDM. METHODS: Apo AI, Apo AII, Apo B, Apo CII, Apo CIII and Apo E levels were measured in 95 women with normal glucose tolerance, 12 weeks following an index GDM pregnancy...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Metformin was found to decrease serum levels of prolactin and thyrotropin. The aim of this study was to investigate the effect of this drug on hypothalamic-pituitary-ovarian axis activity in postmenopausal women with recently diagnosed and untreated glucose metabolism abnormalities. METHODS: The study included three matched groups of postmenopausal women: patients with type 2 diabetes (group A, n=16), women with prediabetes (group B, n=14), and individuals with normal glucose metabolism (group C, n=14)...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Karel Kostev, Alexander Lucas, Louis Jacob
BACKGROUND: The goal of this study was to analyze the frequency of blood pressure (BP) and estimated glomerular filtration rate (eGFR) testing in type 2 diabetes mellitus (T2DM) patients followed in general and diabetological practices in Germany. METHODS: The study included individuals who had at least two concultations due to T2DM diagnosis (ICD-10: E11) between January and December 2016. Patients were followed in 557 general and diabetological practices. The primary outcome was the frequency of BP and eGFR testing in T2DM patients in 2016...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Nevenka Jelić-Knezović, Semira Galijašević, Mila Lovrić, Marina Vasilj, Sanja Selak, Ivanka Mikulić
INTRODUCTION: Endothelial dysfunction is involved in the pathogenesis of insulin resistance, diabetes mellitus type 2, diabetic complications and preceded clinical manifestation of cardiovascular complications. Increased myeloperoxidase activity has been linked to a number of pathologies with compelling evidence in initiation and progression of inflammatory events. The aim of this study was to compare concentrations of metabolite nitric oxide and myeloperoxidase in the plasma of diabetes mellitus type 2 patients on metformin therapy, without clinical signs of cardiovascular disease and healthy subjects, as well as evaluation of concentrations of analytes in association with glycemic control...
March 12, 2018: Experimental and Clinical Endocrinology & Diabetes
Jan Ulrich, Julia Goerges, Christoph Keck, Dirk Muller-Wieland, Sven Diederich, Onno Eilard Janssen
BACKGROUND: Autoimmune thyroiditis (AIT) has been found to be associated with polycystic ovary syndrome (PCOS). The aim of this retrospective cohort study using data from a fertility clinic, with patients recruited from 2009 to 2010, was to confirm the higher prevalence of AIT in PCOS and to evaluate the impact of AIT on reproductive and metabolic parameters of PCOS patients. METHODS: Patients comprised 827 PCOS subjects seen for reproductive or metabolic complaints...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Agnieszka Szypowska, Anna Ramotowska, Marta Wysocka-Mincewicz, Artur Mazur, Lucyna Lisowicz, Iwona Beń-Skowronek, Joanna Sieniawska, Bożenna Klonowska, Dorota Charemska, Jolanta Nawrotek, Irena Jałowiec, Artur Bossowski, Milena Jamiołkowska, Beata Pyrżak, Grażyna Miszkurka, Mieczysław Szalecki
AIM: The seasonal variation of incidence of type 1 diabetes (T1D) theory supports the hypothesis that environmental factors play a role in the onset of the disease. The aim of this study is to assess seasonality of month of diagnosis in children with T1D in Poland. MATERIAL AND METHODS: the study group consisted of 2174 children from eastern and central Poland diagnosed with T1D between 2010 and 2014. Analysis was performed in different age groups, based on place of residence (rural/urban area) and depending on sex...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Fatemeh Ramezani-Aliakbari, Mohammad Badavi, Mahin Dianat, Seyed Ali Mard, Akram Ahangarpour
Trimetazidine (TMZ), as an anti-ischemic drug, plays a critical role in protecting against cardiovascular complications induced by diabetes. This study was therefore aimed to evaluate the protective effects of TMZ on reperfusion-induced arrhythmias in the diabetic rats. Male Sprague-Dawley rats (250±20 g) were randomly assigned to four (n=8): control rats (C), alloxan induced diabetic rats (D), diabetic rats treated with TMZ (10 mg/kg, D+T10), diabetic rats treated with TMZ (30 mg/kg, D+T30). TMZ was treated orally once daily for 8 weeks...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Judit Kocsis, Éva Szekanecz, Ali Bassam, Andrea Uhlyarik, Zsuzsanna Pápai, Gábor Rubovszky, Emese Mezősi, Károly Rucz, Ildikó Garai, Endre Nagy, Iván Uray, Zsolt Horváth
BACKGROUND: Medullary thyroid cancer (MTC) is a rare disease, the prognosis of advanced and metastatic disease is poor and few therapeutic options are available in this setting. Based on the results of phase II and III studies with sorafenib in differentiated thyroid cancer and the lack of availability of registered tyrosine kinase inhibitors, vandetabin and cabozantinib in Hungary, we designed a uncontrolled, prospective efficacy and safety study of patients with metastatic MTC treated with first-line sorafenib in five Hungarian oncology centers...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Hwal Rim Jeong, Hae Sang Lee, Jin Soon Hwang
BACKGROUND: Luteinizing hormone (LH) is a useful parameter in diagnosing precocious puberty. The pubertal response of serum LH to a GnRH stimulation test is varied, and clinical symptoms of precocious puberty are sometimes disproportionate with serum LH concentrations. Many patients present in a state of precocious puberty that advances rapidly, but the post-GnRH peak LH remains prepubertal. LH receptor mutations are suspected of involvement in the non-classic type of central precocious puberty (CPP)...
March 5, 2018: Experimental and Clinical Endocrinology & Diabetes
Franz Maximilian Rasche, Ronny Rettig, Thomas Frese, Wilma Gertrud Rasche, Filip Barinka, Guenter Roesl, Frieder Keller, Tom H Lindner, Jochen G Schneider, Joachim Beige, Thomas Ebert, Stephan Schiekofer
INTRODUCTION: Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. PATIENTS AND METHODS: 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study...
February 23, 2018: Experimental and Clinical Endocrinology & Diabetes
Johanna Zemva, Daniel Pfaff, Jan B Groener, Thomas Fleming, Stephan Herzig, Aurelio Teleman, Peter P Nawroth, Jens Tyedmers
Levels of reactive metabolites such as reactive carbonyl and oxygen species are increased in patients with diabetes mellitus. The most important reactive dicarbonyl species, methylglyoxal (MG), formed as by-product during glucose metabolism, is more and more recognized as a trigger for the development and progression of diabetic complications. Although it is clear that MG provokes toxic effects, it is currently not well understood what cellular changes MG induces on a molecular level that may lead to pathophysiological conditions found in long-term diabetic complications...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Verena Zimmermann-Schlegel, Beate Wild, Peter Nawroth, Stefan Kopf, Wolfgang Herzog, Mechthild Hartmann
OBJECTIVES: To explore the impact of depression on heart rate (HR) and heart rate variability (HRV) as a marker of autonomic nervous system (ANS) impairment in depressed and non-depressed patients with advanced type 2 diabetes mellitus (T2DM) and to explore possible effects of an acceptance- and mindfulness-based group intervention (MBSR) on HR and HRV. METHODS: Alongside a prospective clinical trial, we collected demographic, psychosocial and clinical data from 113 chronic T2DM patients in a standardized setting...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Zhong-Hua Xu, Xing Zhang, Hua Xie, Jin He, Wen-Chao Zhang, Dan-Feng Jing, Xiang Luo
BACKGROUND: As a novel adipokine, CTRP3 involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and adipose tissue via the secretion of adipokines. AIMS: A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women. METHODS: Serum levels of CTRP3 and osteocalcin were measured. Bone mineral density (BMD) was obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Dong Sun, Yanmin Wang, Meng Wei, Zongli Zhang, Sanyuan Hu
BACKGROUND: Sleeve gastrectomy (SG) procedure has been proved to improve insulin sensitivity and sustain anti-diabetic effects. Our aim is to co-use several methods to measure insulin sensitivity and investigate the effect of SG on hepatic and peripheral insulin sensitivity at early and long-term stages of postoperation. METHODS: Thirty 11-week-old male Goto-Kakizaki rats were divided into SG, sham-operated SG (SOSG), and control groups. They were observed before operation and for 36 weeks of postoperation...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
BACKGROUND: Epidemiology studies have revealed that patients with obesity, hyperglycemia, or hypertension are associated with a decreased urine pH. These metabolic disorders are related to insulin resistance; however, the association between urine pH and insulin resistance remains unclear. METHODS: To evaluate this association while controlling for covariates, the present study was conducted in 1084 non-diabetic Japanese subjects undergoing health examination. Fasting urine pH was analyzed using an automated urine dipstick analyzer...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Daniela Gradinaru, Husseina Khaddour, Denisa Margina, Anca Ungurianu, Claudia Borsa, Cristina Ionescu, Gabriel-Ioan Prada, Joshua Usher, Yahya Elshimali
Insulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index (IAR-index)...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Egemen Cebeci, Cengiz Cakan, Meltem Gursu, Sami Uzun, Serhat Karadag, Macit Koldas, Turan Calhan, Serife Aysen Helvaci, Savas Ozturk
AIM: The association of increased resistin levels in chronic kidney disease with diabetic nephropathy has not yet been clarified. Our aim was to analyze the relationship between serum resistin levels and various diabetic microvascular complications in patients. METHODS: A total of 83 patients were enrolled in this cross-sectional study. The subjects were divided into 3 groups: 27 patients with type 2 diabetes mellitus (T2DM) having no diabetic retinopathy (DRP) or microalbuminuria and having normal renal function were included in Group-1, 28 patients with T2DM having DRP and normal renal function in Group-2, and 28 patients with T2DM with DRP and microalbuminuria and an estimated glomerular filtration rate (eGFR) of<60 ml/min/1...
February 8, 2018: Experimental and Clinical Endocrinology & Diabetes
Corina Metaxas, Chantal Zurwerra, Gottfried Rudofsky, Kurt E Hersberger, Philipp N Walter
AIMS: Assessment of the impact of type 2 diabetes (T2DM) and metformin use on vitamin B12 (VB12) associated biomarkers and their suitability to represent VB12 supply. METHODS: Differences of VB12, holotranscobalamine (HoloTc), the biologically active fraction  (%AB12)=HoloTc/VB12*100 and homocystein (Hcy) were analysed i) among diabetic outpatients with (DMMet+ ) and without metformin use (DMMet-) and ii) in comparison to an external non-diabetic reference group with low VB12 (<200 pmol/L)...
February 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Rolf Larisch, John E M Midgley, Johannes W Dietrich, Rudolf Hoermann
AIM: Patients on levothyroxine-treatment frequently have complaints although TSH is within the reference range. Moreover, FT3 is often low in these patients. The clinical significance of this disequilibrium is studied here. PATIENTS, METHODS: We conducted a retrospective longitudinal study including 319 patients with differentiated thyroid carcinoma on LT4-medication (1.8 [1.6,2.1] µg/kg body weight). Patients were followed at 2309 visits for at median 63 [46,81] months...
February 2, 2018: Experimental and Clinical Endocrinology & Diabetes
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