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Experimental and Clinical Endocrinology & Diabetes

Helen Schübert, Ulrich A Müller, Guido Kramer, Nicolle Müller, Tabitha Heller, Christof Kloos, Nadine Kuniss
OBJECTIVE: The aim of this observational study was to analyse snacking pattern and satisfaction with snacking, and to associate snacking patterns with metabolic control and quality of life in people with diabetes type 1 and 2 on insulin therapy. METHODS: In 2017, 390 people with diabetes were interviewed in a university outpatient department: 132 diabetes type 1 (56.1y, diabetes duration 24.2y, HbA1c 7.0%), 89 diabetes type 2/biphasic insulin (72.8y, diabetes duration 22...
July 13, 2018: Experimental and Clinical Endocrinology & Diabetes
Li-Kun Wang, Xue-Liang Wu, Li Shi, Rui-Min Yang, Wei-Liang Liu, Zhen-Shun Hu, Zhi-Hua Zhang, Yi-Cheng Wang
Diabetes remains a long standing public health issue among the Chinese population, with an incidence of up to 11.6%, of which type 2 diabetes mellitus (T2DM) accounts for 85%-95%. During this study, we aimed to elucidate the value of high-frequency ultrasonography (HFUS) combined with serum resistin on vascular remodeling (VR) in carotid atherosclerosis (CA) among patients suffering from T2DM. A total of 432 T2DM were recruited and assigned into the short T2DM duration group (<5 years), middle T2DM duration group (5~10 years) and long T2DM duration group (>10 years), while another 172 healthy cases were recruited as the control group...
July 4, 2018: Experimental and Clinical Endocrinology & Diabetes
Ralf Schiel, Rainer Stachow, Thomas Hermann, Ina Satzke, Thomas Büttner, Sibylle Koch, Katja Enderlein, Rolf Bambauer, Antje Steveling, Esther Bollow, Reinhard W Holl
In the treatment of children/adolescents with diabetes medical rehabilitation plays an important role. It was the aim of the survey to analyze trends in the number of patients admitted to rehabilitation, the quality of diabetes care, the incidence of acute complications, risk factors for cardiovascular co-morbidities like lipids and blood pressure and the familial status nationwide and over a period of 13 years. METHODS: Currently seven hospitals offer in-patient rehabilitation for children/adolescents with diabetes in Germany...
July 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Fang Li, Gulibositan Aji, Yun Wang, Zhiqiang Lu, Yan Ling
PURPOSE: Homocysteine is associated with cardiovascular, inflammation and autoimmune diseases. Previous studies have shown that thyroid peroxidase antibody is associated with homocysteine levels in hypothyroidism. The relationship between thyroid antibodies and homocysteine in hyperthyroidism remains unclear. In this study, we aimed to investigate the association of thyroid antibodies with homocysteine in patients with Graves' disease. METHODS: This was a cross-sectional study including 478 Graves' disease patients who were consecutively admitted and underwent radioiodine therapy...
July 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Alexander Lammert, Marc Sebastian Walter, Frank Anton Giordano, Mansour Al Zhgloul, Bernhard Karl Krämer, Stefanie Nittka, Dirk Michael Schulte, Miriam Ratliff, Daniel Hänggi, Marcel Seiz-Rosenhagen
OBJECTIVE: Pituitary apoplexy is a serious medical complication of a pre-existing pituitary adenoma characterized by a variety of clinical symptoms ranging from mild headache to neurologically impaired and finally comatose patients. Management options are surgery or conservative treatment (e. g., with dexamethasone). Surgery is commonly performed in case of severe acute neurological and visual symptoms. However, prospective studies demonstrating a benefit of surgery over conservative treatment in terms of visual, neurological and even endocrine outcomes are lacking...
July 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Gabriella Iski, Sarolta E Rurik, Imre Rurik
BACKGROUND: Obesity could be considered as the main consequence of unhealthy nutrition, responsible for many pathological alterations in human. Obese patients usually need more health care services. The aim of the study was to estimate the financial expenditures of health care provisions in Hungary, related to obesity and diabetes, as its main pathological consequence. METHODS: Data of the Hungarian National Health Insurance Fund (NHIF) were collected for 2013, regarding finances of secondary care, hospital services, reimbursement for medications and healing aids of diabetic patients together with selected morbidities linked to obesity, based on the codes of the International Classification of Diseases (ICD) and calculated their population prevalence on the population-attributable fraction (PAF)...
July 2, 2018: Experimental and Clinical Endocrinology & Diabetes
Jarek Kobiela, Małgorzata Dobrzycka, Piotr Jędrusik, Paulina Kobiela, Piotr Spychalski, Zbigniew Śledziński, Tomasz Zdrojewski
OBJECTIVES: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. The development of preventive strategies in CRC has been the subject of much research. Multiple studies have shown an association between diabetes and CRC. In addition to its glucose-lowering properties, metformin might have an additional role in the prevention and treatment of CRC. OUR OBJECTIVE: was to summarize findings on role of metformin in colorectal cancer. METHODS: We conducted a systematic review of the PubMed and Cochrane databases from January 2005 to December 2017 in search for studies on the association between metformin and CRC...
June 28, 2018: Experimental and Clinical Endocrinology & Diabetes
Fan-Fan Zhu, Li-Zhen Yang
BACKGROUND: Type 2 diabetes has an underlying pathology with thyroid dysfunction. However, few studies have investigated the association between thyroid hormones and diabetic peripheral neuropathy. Our aim was to evaluate the relationship between thyroid hormones and electrophysiological properties of peripheral nerves in type 2 diabetes. PATIENTS AND METHODS: The medical records of 308 patients with type 2 diabetes were enrolled in this study. Subjects stratified by sex were divided into subgroups based on the diagnosis of nerve conduction study...
June 26, 2018: Experimental and Clinical Endocrinology & Diabetes
Liang Lv, Yu Hu, Senlin Yin, Peizhi Zhou, Yuan Yang, Weichao Ma, Shizhen Zhang, Xiujie Wang, Shu Jiang
Giant prolactinomas represent a rare entity of pituitary tumors so that the management of these patients is still a prevalent challenge at present. Paying special attention to the treatment strategy and outcomes, we presented a large series of 42 cases looking forward to share our understanding and experience in management of these patients. Male patients accounted for 71.4% of this series and were relatively younger (35.70±2.42 vs. 52.00±3.55 years, p=0.0011) and harbored bigger tumors (14.57 vs. 7.74 cm3 , p=0...
June 25, 2018: Experimental and Clinical Endocrinology & Diabetes
Xu Han, Qiaobei Li, Chunyan Wang, Yinyan Li
BACKGROUND: Previous study has been reported that braykinin B2 receptor (Bdkrb2) involves in high glucose-induced renal and podocytes injuries. However, there have been some studies with contradictory results that Bdkrb2 has a protective effect on hyperglycemia-induced injuries in vivo and in vitro. The purpose of the present study was carried out to further investigate the post-transcriptional regulatory mechanism of microRNA (miR) in high glucose-treated podocytes by targeting Bdkrb2 signaling in vitro...
June 25, 2018: Experimental and Clinical Endocrinology & Diabetes
J Liang, Y Zhu, X-K Liu, Q-Q Qiu, Y-T Sun, Y Wang, Y Pei, M-Q Yang, L Qi
BACKGROUND: Obesity is strongly associated with insulin resistance and elevated plasma glucose levels. The rs9356744 polymorphism in the CDKAL1 gene is associated with body mass index (BMI) only in East Asians. Here, we examined the effect of the rs9356744 polymorphism on glucose-related traits and prediabetes in Chinese adults. METHODS: A total of 2 357 participants were enrolled from the Cardiometabolic Risk in Chinese (CRC) Study, including 499 persons with prediabetes, 204 persons with type 2 diabetes, and 1 654 normoglycemic controls...
June 22, 2018: Experimental and Clinical Endocrinology & Diabetes
Ahmed Elgebaly, Nesrine Abdelazeim, Bassant Abdelazeim, Gehad El Ashal, Omar Mattar, Lubaba Namous, Noha Nasreldin
AIM: Ipragliflozin is a new antidiabetic agent that works through enhancing renal glucose excretion. We aim to synthesize evidence from published randomized controlled trials (RCTs) on the safety and efficacy of ipragliflozin in the management of type 2 diabetes mellitus (T2DM). METHODS: We searched PubMed, Scopus, Web of Science, and Cochrane Central register of clinical trials using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager Version 5...
June 18, 2018: Experimental and Clinical Endocrinology & Diabetes
Huihui Yang, Quan E Kan, Yong Su, Hua Man
It's known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. We found that serum level of CASC2 was significantly lower in diabetic nephropathy patients than in normal people, and serum level of CASC2 showed no significant correlations with age, gender, alcohol consumption and smoking habits, but was correlated with course of disease...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Jing Zhao, Xiaoyan Liu, Wenhua Zhang
OBJECTIVE: This study was to analyze the efficacy of metformin intervention in preventing gestational diabetes mellitus (GDM). METHODS: A systematic review and meta-analysis of clinical trials or observational studies of metformin intervention in preventing symptoms of GDM during pregnancy were performed. Medline, Embase, and Cochrane Library were searched through to now. The main evaluated primary outcomes were incident of GDM, miscarriage, preterm delivery, and neonatal mortality...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Maria Demetriou, Nikolaos Papanas, Periklis Panagopoulos, Maria Panopoulou, Efstratios Maltezos
No abstract text is available yet for this article.
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Mario Štefanić, Stana Tokić, Mirjana Suver-Stević, Ljubica Glavaš-Obrovac
BACKGROUND: Co-inhibitory receptors (IR), such as TIGIT and FCRL3, provide a checkpoint against highly destructive immune responses. Co-expression of TIGIT and FCRL3, in particular, has been linked to the HELIOS+ subset of regulatory CD4+ FOXP3+ T-cells. Of these, CD4+ FOXP3-exon(E)2+ cells have higher expression of IR and exhibit strongest suppressive properties. Nevertheless, how the expression of TIGIT, FCRL3, HELIOS, and FOXP3E2 is regulated in chronic autoimmune thyroiditis (AT), is not known...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Can Wu, Xiaoyu Ma, Yang Zhou, Yv Liu, Ying Shao, Qiuyue Wang
Anti-aging protein Klotho is closely associated with a variety of chronic diseases and age-related diseases. And Klotho gene deficiency enhances the phosphorylation of mammalian target of rapamycin (mTOR), resulting in exacerbating streptozotocin-stimulated diabetic glomerular injury and promoting the progression of early diabetic kidney disease (DKD). However, it has not yet been elucidated that the mechanism of Klotho function on the pathogenesis of diabetic glomerular injury. What's more, insulin represents the antilipolytic effect via the mTOR-early growth response factor 1 (Egr1) regulatory axis in mammalian organism...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
John Wilson, Paul Docherty, Richard Stubbs, J Geoffrey Chase, Jeremy Krebs
OBJECTIVE: To compare the dynamic insulin secretion and sensitivity test (DISST) with the euglycaemic clamp in individuals undergoing open Roux-en-Y gastric bypass (RYGB) surgery prior-to and one month after surgery. METHODS: Insulin sensitivity in individuals with obesity undergoing RYGB was studied with DISST and a euglycaemic hyperinsulinaemic clamp. RESULTS: Eleven participants, including nine females, mean(SD) age 51.2(12.1)yrs, with a preoperative BMI of 48...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Rüdiger von Bauer, Dimitrios Oikonomou, Alba Sulaj, Stefan Kopf, Thomas Fleming, Gottfried Rudofsky, Peter Nawroth
Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Beata Telejko, Mariusz Kuzmicki, Monika Zbucka Kretowska, Jacek Szamatowicz, Adam Kretowski
AIM: The aim of the study was to compare the frequency of gestational diabetes mellitus (GDM) and pregnancy outcomes in women diagnosed by WHO 1999 and IADPSG criteria. METHODS: This was a retrospective cohort study comprising 1508 women who underwent a 75-g OGTT after the 24th week of gestation at the University Hospital of Bialystok between 2004 and 2012. RESULTS: GDM was diagnosed by WHO 1999 criteria in 486 (32.2%) patients and by IADPSG criteria in 397 (26...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
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