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Breast Journal

Ruffo Freitas-Junior, Sara Socorro Faria, Régis Resende Paulinelli, Edésio Martins
No abstract text is available yet for this article.
October 13, 2017: Breast Journal
Adonice Khoury, Vikas Parihar, Lillie O'steen, Kartikeya Cherabuddi
Pertuzumab is a monoclonal antibody that targets and down regulates HER-2/neu expression in ductal breast tumors. Other HER-2/neu monoclonal antibodies, particularly trastuzumab, have been implicated to induce infusion related reactions such as cytokine release syndrome (CRS). Here, we report a case of pertuzumab associated CRS prior to infusion of trastuzumab which warranted hospitalization for symptom management.
October 13, 2017: Breast Journal
Luca Sorrentino, Alessandra Sartani, Daniela Bossi, Rosella Amadori, Manuela Nebuloni, Marta Truffi, Matteo Bonzini, Eliana Riggio, Diego Foschi, Fabio Corsi
Sentinel lymph node biopsy for ductal carcinoma in situ (DCIS) of the breast is not standard of care. However, nodal involvement for DCIS patients is reported. Aim of our study was to identify preoperative features predictive of nodal involvement in DCIS patients. We have retrospectively reviewed 175 patients with a preoperative diagnosis of DCIS following a vacuum-assisted breast biopsy, and undergoing surgery with sentinel node biopsy. Variables distribution was compared between patients upstaged to invasive cancer at final pathology and patients with a confirmed DCIS, and between positive vs negative sentinel node patients...
October 11, 2017: Breast Journal
Miri Sklair-Levy, Shlomi Rayman, Ady Yosepovich, Andrew Zbar, David Goitein, Douglas Zippel
The aim of this paper is to evaluate our Unit's initial experience using the Intact breast lesion excision system as a therapeutic excision option for benign or borderline breast lesions, which otherwise would entail open operative excision. The study includes the first 111 patients who underwent therapeutic excision with the intact radiofrequency system between December 2012 and May 2016 performed at the Meirav Center for Breast Health, at the Chaim Sheba Medical Center, Ramat Gan Israel. The indications for the procedure included those patients who have benign, or atypical high risk lesions following a previous core needle biospy (CNB) who would have normally undergone conventional excision biopsy...
October 11, 2017: Breast Journal
Gloria Zhang, Dana Ataya, Paulette L Lebda, Benjamin C Calhoun
Mucocele-like lesions of the breast diagnosed on core biopsy are usually excised to exclude the possibility of partial sampling of an invasive mucinous carcinoma. The goal of this study was to correlate the pathologic and radiologic features of mucocele-like lesions to determine if excision is mandatory. Over a 16 year period we identified 32 patients with mucocele-like lesions diagnosed on 27 (84%) stereotactic and 5 (16%) ultrasound-guided core biopsies. The indications for core biopsy were: calcifications in 24 (75%), a mass in 7 (22%), and a mass with calcifications in 1 (3%)...
October 11, 2017: Breast Journal
Ahmed A Abdulrahman, Rebecca C Heintzelman, Melanie Corbman, Fernando U Garcia
The increasing availability of next-generation sequencing for clinical research dramatically improved our understanding of breast cancer genetics and resulted in detection of new mutation variants. Cancer risk data relating to some of these variants are insufficient, prompting the designation of variants of uncertain significance (VUS). The histopathologic characteristics of these variants have not been previously described. We propose to depict these characteristics and determine if invasive carcinomas with similar VUS genes share similar histomorphologic features...
October 7, 2017: Breast Journal
Lucie Bignon, Jean-Pierre Fricker, Catherine Nogues, Emmanuelle Mouret-Fourme, Dominique Stoppa-Lyonnet, Olivier Caron, Alain Lortholary, Laurence Faivre, Christine Lasset, Veronique Mari, Paul Gesta, Laurence Gladieff, Akila Hamimi, Thierry Petit, Michel Velten
This study aims to estimate the pathologic complete response (pCR) rate after neo-adjuvant chemotherapy and to compare disease-free survival (DFS) and overall survival (OS) between pCR and non-pCR groups of patients with triple-negative breast cancer (TNBC) and deleterious BRCA1 or BRCA2 mutation. We carried out a retrospective analysis of 53 patients including 46 BRCA1, 6 BRCA2, and 1 combined BRCA1 and BRCA2 mutation. All patients had been diagnosed with triple-negative breast cancer (TNBC) between 1997 and 2014...
September 19, 2017: Breast Journal
Carolina E Fasola, Jie Jane Chen, Kristin C Jensen, Kimberly H Allison, Kathleen C Horst
Pleomorphic lobular carcinoma in situ (PLCIS) of the breast is a rare variant of lobular carcinoma in situ (LCIS). We reviewed 78 cases of PLCIS diagnosed at our institution from 1998 to 2012. Among all cases, 47 (60%) were associated with invasive carcinoma and/or ductal carcinoma in situ (DCIS) after final surgical excision. Of the 20 cases with PLCIS alone on core needle biopsy (CNB), 6 (30%) were upgraded to invasive carcinoma or DCIS after final surgical excision. Our findings support a recommendation for complete surgical excision of PLCIS when diagnosed on CNB...
September 19, 2017: Breast Journal
Kyle Ota, Carmen Rivera, Maureen Martin
No abstract text is available yet for this article.
September 15, 2017: Breast Journal
Nikolaos S Salemis, Ilias Katikaridis, Christos Birpanagos, Dimitrios Sambaziotis, Aggelos Sofronas
No abstract text is available yet for this article.
September 13, 2017: Breast Journal
George Filobbos, Nathan Hamnett, Joseph Hardwicke, Joanna Skillman
The inferior de-epithelialized dermal flap with implant is increasingly used for immediate breast reconstruction. We have adapted the technique to provide concurrent immediate nipple reconstruction by recruiting the triangle of skin above the excised nipple as a modified C-V flap. The safety and efficacy of this technique has been assessed in 15 patients, of which eight were bilateral and seven were unilateral cases. We suggest that this is a safe, reliable, and original technique for immediate nipple reconstruction in patients undergoing immediate breast reconstruction with an inferior dermal sling and implant...
September 11, 2017: Breast Journal
Wilfrido D Mojica, Margaret Brandwein-Weber, Elizabeth A Korangy
No abstract text is available yet for this article.
September 11, 2017: Breast Journal
Hiu Kwan Carolyn Tang, Doreen Yin Hui Lee, Ian Thompson, John R Ingram, Natalie Stone, Girish K Patel
Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment. In contrast, occurrence of generalized pemphigus vulgaris in this setting may mean cancer recurrence...
September 11, 2017: Breast Journal
Yi-Ling Yang, Xiao-Long Qian, Li Fu
No abstract text is available yet for this article.
September 6, 2017: Breast Journal
Niketa Chotai, Elizabeth Fok, Patrick Chan, Bernard Ho
No abstract text is available yet for this article.
September 6, 2017: Breast Journal
Juana Brenes, Arancha Moreno, M Jesús Merchán, Myriam Montes, M José Ciudad, Cristina Riola, M Eugenia Olivares, José A Cortés, M Ángeles Cuadrado, José M Román
No abstract text is available yet for this article.
September 6, 2017: Breast Journal
Ebru Düşünceli Atman, Melahat Kul, Mustafa Fatih Arslan, Çağlar Uzun, Evren Üstüner
No abstract text is available yet for this article.
September 6, 2017: Breast Journal
Bommie F Seo, Hyuk Joon Choi, Sung-No Jung
No abstract text is available yet for this article.
August 29, 2017: Breast Journal
Aju Mathew, Tala Achkar, Shira Abberbock, Gurprataap S Sandhu, Mini Elizabeth Jacob, Vipin Das Villgran, Margaret Q Rosenzweig, Shannon Puhalla, Adam M Brufsky
Cessation of chemotherapy in the last few weeks of life could be an important quality-of-care benchmark. Proportion of metastatic breast cancer patients who receive end-of-life chemotherapy is not well described. We aimed to determine the prevalence and determinants of end-of-life chemotherapy use in patients with metastatic breast cancer. A retrospective cohort study using a prospectively collated database of patients with metastatic breast cancer who died between January 1, 2010, and September 30, 2014, was conducted...
August 28, 2017: Breast Journal
Elissa R Price, Edward A Sickles, Silaja Yitta, Natasha Brasic, Melinda J Yeh, Isabel E Allen, Bonnie N Joe
The purpose of this study was to identify potential BI-RADS 3 mass descriptors on breast magnetic resonance imaging by systematically defining positive predictive values (PPV). In a blinded retrospective review of BI-RADS 4 masses, reader 1 identified 132 masses and reader 2 identified 76 masses. PPV for mass descriptors and for descriptor combinations was determined. No mass descriptor resulted in a PPV ≤2% (BI-RADS 3 threshold). Descriptors with the lowest PPVs were circumscribed margin (8%), rim internal enhancement and persistent kinetics (13% each), and oval shape (15%)...
August 27, 2017: Breast Journal
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