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European Journal of Oral Sciences

Heithem Ben Amara, Hyun Y Song, Eunju Ryu, Ji S Park, Frank Schwarz, Byeong M Kim, Bong-Kyu Choi, Ki-Tae Koo
This study aimed to verify, in in vivo settings, whether quorum-sensing inhibition molecules could attenuate alveolar bone loss induced by Porphyromonas gingivalis/Fusobacterium nucleatum co-infection and reduce the bacterial colonization of periodontal tissues. In BALB/c mice, periodontitis was induced through oral inoculation with P. gingivalis and F. nucleatum six times during a 42-d period. Quorum sensing inhibitors (a furanone compound and D-ribose) were administered simultaneously with bacterial infection...
September 19, 2018: European Journal of Oral Sciences
Pamela Uribe, Pawel Plakwicz, Lena Larsson, Ewa Czochrowska, Anna Westerlund, Maria Ransjö
We sought to investigate site-specific expression of bone-regulatory factors expressed by human dental follicles and to compare the stimulated expression of tumour necrosis factor (ligand) superfamily, member 11/tumour necrosis factor receptor superfamily, member 11b (RANKL/OPG) in human dental follicle cells (HDFCs) from different patients. Analysis of bone-regulatory markers in follicles from 12 different study participants was performed using RT-qPCR and immunofluorescence; apical and coronal segments from each dental follicle were processed independently...
September 14, 2018: European Journal of Oral Sciences
Leng Wu, Lei Zhao, Jun Wang, Chengcheng Liu, Yan Li, Yafei Wu
Bacterial metabolism during infection is related to bacterial persistence and virulence factors. Porphyromonas gingivalis is a key pathogen that contributes to chronic periodontitis. Our previous study showed that pckA, the gene encoding phosphoenolpyruvate carboxykinase, is a putative-specific pathogenic gene of virulent strains of P. gingivalis. Here, a pckA-deficient strain (ΔPG1676) was constructed in P. gingivalis W83. Virulence properties were compared between the mutant and wild-type strains. Specifically, hemagglutination activity was determined by the ability to agglutinate sheep erythrocytes...
August 20, 2018: European Journal of Oral Sciences
(no author information available yet)
No abstract text is available yet for this article.
October 2018: European Journal of Oral Sciences
Stina Syrjänen
Papillomaviruses are one of the oldest viruses known, dating back 330 million years. During this long evolution, human papillomaviruses (HPV) have developed into hijackers of human cellular and immune systems in which they replicate and remain silent. Systematic studies on oral HPV infections and their outcomes are still scarce. Oral HPV infections have been linked to sexual behaviour, but recent evidence supports their horizontal, mouth-to-mouth, transmission. Most HPV infections in infants are acquired vertically from the mother during the intrauterine period, during delivery, or later via saliva...
October 2018: European Journal of Oral Sciences
Mogens Kilian
The microbiome and the human body constitute an integrated superorganism, which is the result of millions of years of coevolution with mutual adaptation and functional integration, and confers significant benefits for both parties. This evolutionary process has resulted in a highly diverse oral microbiome, which covers the full spectrum of acidogenic, aciduric, inflammatory, and anti-inflammatory properties. The relative proportions of members of the microbiome are affected by factors associated with modern life, such as general diet patterns, sugar consumption, tobacco smoking, oral hygiene, use of antibiotics and other antimicrobials, and vaccines...
October 2018: European Journal of Oral Sciences
Sven Kreiborg, B L Jensen
The principles of formation, renewal, and eruption of teeth are discussed. Numerous genetic aberrations may affect the formation and eruption of teeth. Cleidocranial dysplasia (CCD), caused by mutations in the runt-related transcription factor 2 (RUNX2) gene, is such a condition. The dental phenotype includes problems in both tooth formation (multiple supernumerary permanent teeth) and tooth eruption (lack of shedding of primary teeth and delayed or arrested eruption of permanent teeth). Clinical studies, animal models, and molecular biology studies have documented that RUNX2 is of paramount importance for osteoblast differentiation, for regression of the dental lamina, and for osteoclastogenesis in the dental follicle and the periodontal ligament...
October 2018: European Journal of Oral Sciences
Håkon Valen, Anne A Scheie
Bacteria within the oral cavity live primarily as complex, polymicrobial biofilms. Dental biofilms are necessary etiological factors for dental caries and periodontal diseases but have also been implicated in diseases outside the oral cavity. Biofilm is the preferred lifestyle for bacteria, and biofilms are found on almost any surface in nature. Bacteria growing within a biofilm exhibit an altered phenotype. Substantial changes in gene expression occur when bacteria are in close proximity or physical contact with one another or with the host...
October 2018: European Journal of Oral Sciences
Svante Twetman
Today, dental caries is regarded as a preventable non-communicable disease (NCD) that affects a majority of the population across their lifespan. As such, it shares a number of behavioural, socio-economic, and lifestyle factors with other NCDs, such as overweight and diabetes, and should be subjected to a similar model of chronic disease management. Caries prevention has traditionally relied on fluoride exposure, diet control, thorough oral hygiene, and antibacterial measures. Prevention of caries as an NCD does certainly not disqualify these methods, but brings them into a new context...
October 2018: European Journal of Oral Sciences
Irma Thesleff
Remarkable breakthroughs in the fields of developmental biology and stem cell biology during the last 15 yr have led to a new level of understanding regarding how teeth develop and how stem cells can be programmed. As a result, the possibilities of growing new teeth and of tooth bioengineering have been explored. Currently, a great deal is known about how signaling molecules and genes regulate tooth development, and modern research using transgenic mouse models has demonstrated that it is possible to induce the formation of new teeth by tinkering with the signaling networks that govern early tooth development...
October 2018: European Journal of Oral Sciences
Pekka K Vallittu, Bangalore H Durgesh, AbdulAziz A AlKheraif, Jenni Hjerppe
In dentistry, isotropic materials, such as metals, ceramics, and polymers, are used. Their properties are not related to any specific direction of the material microstructure. There is a trend toward non-metallic, adhesive, and minimally invasive dentistry. This is in line with the conceptual change seen in the automobile industry, in which the basis of car structures has changed from body-on-frame designs to unibody designs. In unibody designs, all structural parts of the body of the car mechanically form a single structural entity...
October 2018: European Journal of Oral Sciences
Björn Klinge, Anna Klinge, Kristina Bertl, Andreas Stavropoulos
When celebrating 100 yr of dental research in the Nordic dental research community (i.e. Nordisk Odontologisk Förening (NOF)), it is relevant to include dental implant treatment. In essence, the successful progress of implant treatment has added both to the quality of life for patients and also to many aspects of professional development and job satisfaction for dentists. When appreciating the success story it also seems relevant to highlight some of the problems related to this treatment. Both technical and biological complications have often been ignored when reporting long-term results following implant treatment...
October 2018: European Journal of Oral Sciences
Roland Jonsson, Karl A Brokstad, Malin V Jonsson, Nicolas Delaleu, Kathrine Skarstein
Sjögren's syndrome is a lymphoproliferative disease with autoimmune features characterized by mononuclear cell infiltration of exocrine glands, notably the lacrimal and salivary glands. These lymphoid infiltrations lead to dryness of the eyes (keratoconjunctivitis sicca), dryness of the mouth (xerostomia), and, frequently, dryness of other surfaces connected to exocrine glands. Sjögren's syndrome is associated with the production of autoantibodies because B-cell activation is a consistent immunoregulatory abnormality...
October 2018: European Journal of Oral Sciences
Jon E Dahl, Ida S R Stenhagen
This paper discusses aspects of quality and safety improvement of the most commonly used dental restorative materials, the resin-based composites. From a patient's perspective, long-lasting resin-based restorations without complications are important. Recurrent caries and fracture are the most common causes for restoration failures. Proper handling and curing of the composites improve the mechanical properties of the restorations and increase safety by reducing exposure to residual methacrylate monomers. A number of compounds have been introduced in restorative materials to reduce the risk of recurrent caries, even though a real breakthrough has not yet been achieved...
October 2018: European Journal of Oral Sciences
Bjarni E Pjetursson, Kristin Heimisdottir
Nowadays, patients find much information on dental treatment from the Internet. There is a vast amount of information on dental implants, in contrast to the limited information available on natural teeth. This review addresses research on survival of natural teeth and dental implants, and discusses factors affecting the survival rate of implants, as well as certain dogmas in implant dentistry. To simplify treatment planning, the article presents a classification system in which teeth are classified as secure, doubtful, or irrational to treat...
October 2018: European Journal of Oral Sciences
Milla Pietiäinen, John M Liljestrand, Elisa Kopra, Pirkko J Pussinen
Clinical periodontitis is associated with an increased risk for cardiovascular diseases (CVDs) through systemic inflammation as the etiopathogenic link. Whether the oral microbiota, especially its quality, quantity, serology, and virulence factors, plays a role in atherogenesis is not clarified. Patients with periodontitis are exposed to bacteria and their products, which have access to the circulation directly through inflamed oral tissues and indirectly (via saliva) through the gastrointestinal tract, resulting in systemic inflammatory and immunologic responses...
October 2018: European Journal of Oral Sciences
Eija Könönen, Anne Marie Lynge Pedersen
No abstract text is available yet for this article.
October 2018: European Journal of Oral Sciences
Matej Par, Zrinka Tarle, Reinhard Hickel, Nicoleta Ilie
The real-time polymerization of light-curable experimental resin composites filled with amorphous calcium phosphate (ACP) was monitored. Experimental composites were based on a 2,2-bis[4-(2-ethoxy-3-methacryloyloxy propoxy)phenyl]propane (Bis-EMA)/triethyleneglycol dimethacrylate (TEGDMA)/2-hydroxyethyl methacrylate (HEMA) resin photoactivated by a camphorquinone/tertiary amine system. Four ACP composites were prepared, containing 40 wt% ACP and 0/10 wt% reinforcing fillers (barium glass and silica). Additionally, two control composites were prepared which contained only reinforcing fillers (40-50 wt%)...
October 2018: European Journal of Oral Sciences
Daniel Neu, Nina Baniasadi, Johan Newell, David Styczen, Régine Glineur, Olivier Mairesse
Sleep-related bruxism may directly impact sleep quality. This study aims to evaluate potential relationships between sleep bruxism events and related daytime symptoms. We investigated 22 patients (42.1 ± 11.6 yr of age) with sleep bruxism in comparison with 12 good sleeper control subjects of similar age (41.0 ± 11.5 yr). Sleep bruxism was visually analyzed and categorized according to sleep stage, bruxism type (tonic/phasic) and duration. Clinical instruments comprised the Epworth Sleepiness, the Brugmann Fatigue Scale, and the Hospital Anxiety and Depression Rating Scale...
October 2018: European Journal of Oral Sciences
Xuenan Liu, Nan Li, Hua Zhang, Jing Liu, Nan Zhou, Chunxiao Ran, Xiaoyan Chen, Yongbo Lu, Xiaofang Wang, Chunlin Qin, Jing Xiao, Chao Liu
The glycosaminoglycan (GAG) chains attached to the core proteins of proteoglycans exert multiple roles, such as enriching signal molecules and regulating the binding of ligands to the corresponding receptors. A newly identified kinase - family with sequence similarity 20 member B (FAM20B) - is essential for the formation of GAG chains. The FAM20B protein phosphorylates the initial xylose on the side chain of a serine residue in the protein. Although the GAG chains of proteoglycans are believed to be indispensable during craniofacial development, there are few reports on their exact functions in craniofacial organogenesis...
October 2018: European Journal of Oral Sciences
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