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Skin Research and Technology

W Hua, L-M Fan, R Dai, M Luan, H Xie, A-Q Li, L Li
BACKGROUND/PURPOSE: The detectors from Courage & Khazaka and DermaLab(®) from Cortex Technology were two series of the most commonly used non-invasive instruments for the skin physiological properties measurements. The aim of this study is to reveal the differences and correlations in measuring skin color, hydration, transepidermal water loss (TEWL), sebum and elasticity on the forearm or faces between two commercially available series of instruments. METHODS: 30 subjects were enrolled to be measured by the two series of instruments...
September 16, 2016: Skin Research and Technology
E M Kearney, C Messaraa, G Grennan, G Koeller, A Mavon, E Merinville
BACKGROUND: One of the key strategies for anti-ageing in the cosmetics industry today is to target the structural changes responsible for ptosis of the skin, given its impact on age perception. Several objective and non-invasive methods are available to characterise the biomechanical properties of the skin, which are operator-dependent, involving skin contact and providing single-dimensional numerical descriptions of skin behaviour. The research introduces the DynaSKIN, a device using non-contact mechanical pressure in combination with fringe projection to quantify and visualise the skin response in 3-dimensions...
August 21, 2016: Skin Research and Technology
A Bozkurt, K Kose, C Alessi-Fox, J G Dy, D H Brooks, M Rajadhyaksha
BACKGROUND: Measuring the thickness of the stratum corneum (SC) in vivo is often required in pharmacological, dermatological, and cosmetological studies. Reflectance confocal microscopy (RCM) offers a non-invasive imaging-based approach. However, RCM-based measurements currently rely on purely visual analysis of images, which is time-consuming and suffers from inter-user subjectivity. METHODS: We developed an unsupervised segmentation algorithm that can automatically delineate the SC layer in stacks of RCM images of human skin...
August 12, 2016: Skin Research and Technology
J Kim, J W Ahn, S Ha, S H Kwon, O Lee, C Oh
BACKGROUND: Rosacea is a common chronic inflammatory disorder affecting facial skin. Currently, no accurate and objective method is available for assessing the severity of rosacea. Most studies use the National Rosacea Society Standard (NRSS) grading method, which lacks objectivity and yields varying results. METHODS: Eighteen patients with rosacea were included. Clinical severity was assessed on the basis of the NRSS grade, Investigators' Global Assessment, Patients' Global Assessment, and Dermatology Quality of Life Index...
August 12, 2016: Skin Research and Technology
T-R Kwon, S Im, Y-J Jang, C T Oh, E J Choi, S J Jung, H Hong, Y S Choi, S Y Choi, Y S Kim, B J Kim
BACKGROUND: Non-invasive body sculpting procedures are becoming increasingly popular. High-intensity focused ultrasound (HIFU) treatment is a non-surgical fat reduction procedure that permanently destroys unwanted abdominal fat. Despite its increasing popularity, evaluation methods for the procedure have not yet been fully developed. AIMS: The objective of this study was to develop evaluation methods for HIFU for non-surgical, permanent fat reduction in the anterior abdomen using a porcine model...
August 11, 2016: Skin Research and Technology
J H Yim, K H Jeong, M K Shin
BACKGROUND/PURPOSE: Treatment of atopic dermatitis (AD) and psoriasis requires their differentiation from other eczematoid dermatitis and a determination of disease severity. However, both can be clinically difficult and the findings subjectively interpreted. We investigated the utility of in vivo autofluorescence (AF) measurements for diagnosis of both diseases, and determination of severity. MATERIALS AND METHODS: Thirty patients with AD and 30 with psoriasis were recruited, together with sex- and age-matched patients with healthy skin...
August 11, 2016: Skin Research and Technology
J H Yim, K H Jeong, J Y Kim, Y H Cho, S J Bae, M K Shin
BACKGROUND/PURPOSE: Various methods have been used to objectively record skin changes. However, estimating the intrinsic and extrinsic aging of skin remains a challenge. Our objective was to study intrinsic skin aging with respect to patient age and extrinsic photo-aging of human dorsal (photo-exposed) and volar (photo-protected) forearm in vivo through skin auto-fluorescence (AF). We also examined the correlations between serum antioxidant enzyme, malondialdehyde(MDA), and skin AF. METHODS: 37 healthy volunteers were enrolled...
August 11, 2016: Skin Research and Technology
K-P Wilhelm, D Wilhelm, S Bielfeldt
BACKGROUND: The healing of wounds has always provided challenges for the medical community whether chronic or acute. Understanding the processes which enable wounds to heal is primarily carried out by the use of models, in vitro, animal and human. It is generally accepted that the use of human models offers the best opportunity to understand the factors that influence wound healing as well as to evaluate efficacy of treatments applied to wounds. OBJECTIVES: The objective of this article is to provide an overview of the different methodologies that are currently used to experimentally induce wounds of various depths in human volunteers and examines the information that may be gained from them...
August 9, 2016: Skin Research and Technology
V L Newton, R S Bradley, P Seroul, M Cherel, C E M Griffiths, A V Rawlings, R Voegeli, R E B Watson, M J Sherratt
BACKGROUND/PURPOSE: The dermal-epidermal junction (DEJ) forms epidermal protrusions down into the dermis (rete ridges) and dermal projections up into the epidermis (dermal papillae). Usually visualized in two-dimensions (2D), our knowledge of how the DEJ changes with ageing is limited. We aimed to characterize how this structure exists in 3D and changes with age. METHODS: Photoprotected and photoexposed skin were imaged using reflectance confocal microscopy (RCM) in young and aged individuals...
August 9, 2016: Skin Research and Technology
M M Trowbridge, B Wang, D Gutshall, C A Rodenberg, M A Farage
BACKGROUND/PURPOSE: It is important to confirm product use effects on skin health for products intended for prolonged skin contact. This study compared experimental and marketed reference adult incontinence protective underwear. METHODS: Randomized, single-blind (examiner), parallel study evaluating skin health effects in predominantly obese incontinent women normally using protective underwear (approximately 20% Type II Diabetes). Subjects wore experimental or marketed reference protective underwear daily, 14 consecutive days...
August 8, 2016: Skin Research and Technology
T Fujimura, Y Shimotoyodome, T Nishijima, K Sugata, H Taguchi, S Moriwaki
BACKGROUND/PURPOSE: Irritancy levels of surfactants on human skin have not been clarified completely. The relationships between skin damage and changes of skin properties caused by various surfactants were investigated using non-invasive measurements. METHODS: Aqueous solutions of seven kinds of anionic, non-ionic, and amphoteric surfactants were exposed to the inside of forearm skin of 20 human subjects in two separate studies using the cup method. Hydration of the stratum corneum (SC), transepidermal water loss (TEWL), pH, skin surface roughness, and contents of the SC were measured before and after one exposure and after five and nine consecutive exposures to various surfactants...
August 8, 2016: Skin Research and Technology
F M W Rodijk, G Zanelli, M Geerligs, P E J van Erp, M Peppelman
BACKGROUND: The impact of personal care devices on skin is mainly assessed using subjective tools. However, new objective, accurate non-invasive in vivo imaging techniques have been developed. The aim of this study was to evaluate the ability of reflectance confocal microscopy (RCM) in quantifying morphological impact of shavers on skin. Furthermore, tape stripping (TS) as method to study morphological impact of shavers was evaluated. METHODS: In 12 healthy male subjects, for two consecutive days, a split-face test was performed in the neck; on one side a shaver was applied, while the other side was exposed to TS...
August 2016: Skin Research and Technology
L Sun, X Wang, Y Zhang, T Wang, X Li, Y Ma
BACKGROUND: The impaired barrier function has been studied comprehensively but few about the heighted neural and vascular reaction for the pathogenesis of sensitive skin. METHODS: Lactic acid stinging test (LAST) was used to identify sensitive subjects in selection phase. In the subsequent test phase, the baseline value of the blood flow (BF) and the current perception threshold (CPT) was measured by non-invasive instruments firstly. Then, the 0.001% capsaicin was applied to the nasolabial fold for 5 min...
August 2016: Skin Research and Technology
K Kikuchi, Y Masuda, T Yamashita, K Sato, C Katagiri, T Hirao, Y Mizokami, H Yaguchi
BACKGROUND: Facial skin pigmentation is one of the most prominent visible features of skin aging and often affects perception of health and beauty. To date, facial pigmentation has been evaluated using various image analysis methods developed for the cosmetic and esthetic fields. However, existing methods cannot provide precise information on pigmented spots, such as variations in size, color shade, and distribution pattern. The purpose of this study is the development of image evaluation methods to analyze individual pigmented spots and acquire detailed information on their age-related changes...
August 2016: Skin Research and Technology
M Djaghloul, F Morizot, H Zahouani
BACKGROUND: In this work, we propose an innovative approach based on a rotary tribometer coupled with laser velocimetry for measuring the elastic wave propagation on the skin. METHODS: The method is based on a dynamic contact with the control of the normal force (Fn ), the contact length and speed. During the test a quantification of the friction force is produced. The elastic wave generated by friction is measured at the surface of the skin 35 mm from the source of friction exciter...
August 2016: Skin Research and Technology
D J J Van Neste, D H Rushton
BACKGROUND: Hair loss is related to follicular density, programmed regrowth and hair productivity. OBJECTIVE: The dissatisfaction with hair growth in patients experiencing hair loss might be due to slower linear hair growth rate (LHGR). METHODS: LHGR and hair diameter was evaluated in Caucasian controls and patients with patterned hair loss employing the validated non-invasive, contrast-enhanced-phototrichogram with exogen collection. RESULTS: We evaluated 59,765 anagen hairs (controls 24,609, patients 35,156) and found thinner hairs grew slower than thicker hairs...
August 2016: Skin Research and Technology
A Raina, R Hennessy, M Rains, J Allred, J M Hirshburg, D G Diven, M K Markey
BACKGROUND: Traditional metrics for evaluating the severity of psoriasis are subjective, which complicates efforts to measure effective treatments in clinical trials. METHODS: We collected images of psoriasis plaques and calibrated the coloration of the images according to an included color card. Features were extracted from the images and used to train a linear discriminant analysis classifier with cross-validation to automatically classify the degree of erythema...
August 2016: Skin Research and Technology
A Houcine, A Delalleau, S Heraud, B Guiraud, B Payre, H Duplan, M-B Delisle, O Damour, S Bessou-Touya
BACKGROUND: The reliability of the biophysical properties of skin equivalents (SEs) remains a challenge for medical applications and for product efficacy tests following the European Directive 2003/15/EC2 on the prohibition of animal experiments for cosmetic products. METHODS: We propose to adapt the biophysical in vivo testing techniques to compare full thickness model growth vs. time. The interest in using such techniques lies in possible comparisons between in vivo and in vitro skin as well as monitoring samples over the culture time...
August 2016: Skin Research and Technology
S Springer, M Zieger, K Koenig, M Kaatz, J Lademann, M E Darvin
BACKGROUND: The in vivo multiphoton tomography has evolved into a useful tool for the non-invasive investigation of morphological and biophysical characteristics of human skin. Until now, changes of skin have been evaluated mainly by clinical and histological techniques. The current study addresses the effects of a changed acquisition time for single scans in a Z-stack on the directly related qualitative and quantitative interpretability of the data. METHODS: A test area of the skin was used for scanning 12 Z-stacks of 10 volunteers aged between 25 and 34 years...
August 2016: Skin Research and Technology
J H-L Lim, W Choo, J H Chang, H L Tey, W-S Chong
BACKGROUND: Hypohidrosis is defined as diminished sweating in response to an appropriate thermal or sympathetic stimulus. When encountered in a clinical setting, it necessitates an accurate documentation of its pattern and extent to prognosticate the risk of associated heat-related illnesses. This can be achieved by thermoregulatory sweat testing which includes a starch-iodine sweat test that can be administered via various methods. OBJECTIVE: To describe and evaluate the effectiveness and safety of a novel method of using an atomizer spray gun in administering the starch-iodine test...
August 2016: Skin Research and Technology
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