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Skin Research and Technology

George P Majewski, Katie Rodan, Kathy Fields, Timothy J Falla
BACKGROUND: Hyaluronic acid (HA) has been considered the gold standard ingredient for improving skin hydration and combating age-related effects, however it is an inefficient polymer with inconsistent results partially due to its poor skin penetration, surface deposition, and rapid degradation. Herein we report the synthesis and in vitro characterization of a newly developed, topical super-humectant with the goal of attracting and binding water molecules more efficiently than traditional, cosmetic-grade forms of HA...
August 16, 2018: Skin Research and Technology
Anna Dai, Shibin Wang, Lei Zhou, Huixin Wei, Zhiyong Wang, Wei He
BACKGROUND: The mechanical properties of human facial skin are of considerable importance for clinical research and cosmetic industry. As a result of their susceptibility to the individual difference and complex surroundings of human beings, the in vivo mechanical characterization by objective and quantitative devices is challenging. METHODS: In this study, an experimental setup was custom-designed for the mechanical characterization combining curved surface optical imaging and indentation techniques...
August 2, 2018: Skin Research and Technology
E-J Shin, J-K Seo, E J Lee, E S Lee, M K Shin
BACKGROUND: The standard diagnostic test for allergic contact dermatitis is the patch test, which can also be used to identify irritant contact dermatitis. Doubtful reactions (?+) can be often clinically relevant to individuals and can require additional tests. OBJECTIVES: The purpose of this study was to examine whether autofluorescence (AF) measurements in patients with doubtful reactions are helpful in diagnosing contact dermatitis. METHODS: Patients with a history of contact dermatitis were patch tested on the upper back for 48-hours of occlusion using aqueous solutions of 5% sodium lauryl sulfate...
July 28, 2018: Skin Research and Technology
J Gao, C Liu, S Zhang, M P Techer, S Bouabbache, F Pouradier, S Panhard
BACKGROUND: The regreasing process of hair by sebum is daily observed by consumers. Methods to investigate this phenomenon were scarcely updated since the 1990s, despite the constant progresses in hair cleaning procedures or shampoo formulations. Our objective was first, to develop an in vivo noninvasive method for quantifying the spread of sebum along the hair shaft. Secondly, we use this new method to define the overall kinetics of the hair-regreasing process among two cohorts of Chinese men with opposite self-perceptions of their scalp/hair greasiness (ie, greasy or not greasy)...
July 25, 2018: Skin Research and Technology
Karan Agrawal, Raja K Sivamani, John W Newman
BACKGROUND AND OBJECTIVE: Recent increases in the use of noninvasive matrices for biomedical analysis has led to interest in the evaluation of sweat for both clinical and research applications. However, despite being one of the two main cutaneous secretions, until very recently, only one study actually analyzed sweat in the context of cutaneous disease. This review attempts to make the case for increased use of sweat in cutaneous research, and discusses lipid mediators as potential analytical targets in sweat...
July 21, 2018: Skin Research and Technology
D Y Kim, T M Ahn, Y C Kye, S H Seo
BACKGROUND: Car drivers are generally exposed to direct sunlight during commuting hours, which may lead to irreversible skin damage; however, topographical analysis for different facial areas has not been reported. METHODS: Facial areas were divided topographically into 11 areas based on esthetic units. We performed a preliminary study to identify the delivery pattern of solar energy on the face in the car during commuting time; subsequently, 15 drivers aged above 50 years were enrolled...
July 21, 2018: Skin Research and Technology
G Nazzaro, F Germiniasi, E Passoni, S Veraldi
No abstract text is available yet for this article.
July 21, 2018: Skin Research and Technology
Nivedita Singh, Shailendra K Gupta
BACKGROUND: The paper reviews the advancement of tools and current technologies for the detection of melanoma. We discussed several computational strategies from pre- to postprocessing image operations, descriptors, and popular classifiers to diagnose a suspected skin lesion based on its virtual similarity to the malignant lesion with known histopathology. We reviewed the current state of smart phone-based apps as diagnostic tools for screening. METHODS: A literature survey was conducted using a combination of keywords in the bibliographic databases: PubMed, AJCC, PH2, EDRA, and ISIC melanoma project...
July 21, 2018: Skin Research and Technology
I Ranosz-Janicka, A Lis-Święty, A Skrzypek-Salamon, L Brzezińska-Wcisło
BACKGROUND: The disease phase in localized scleroderma (LoS) is commonly assessed by clinical investigation using the LoS cutaneous assessment tool (LoSCAT). There is a need for more objective methods for assessing the degree of activity/inflammation in LoS. The aim of our work was to evaluate the correlation between severity of the LoS lesions scored using LoSCAT and the degree of hyperthermia observed with infrared thermography (IRT). MATERIALS AND METHODS: The LoS lesions were examined using the LoSCAT and IRT independently by two examiners...
July 21, 2018: Skin Research and Technology
Monica M Young, Anja Franken, Johan L du Plessis
BACKGROUND: Conflicting evidence exists on how skin barrier function compares between Africans and Caucasians. This study measured skin barrier function of South African first year nursing students before their practical training started to compare skin barrier function between the racial groups. METHODS: Transepidermal water loss (TEWL), stratum corneum (SC) hydration, and skin surface (SS) pH was measured on female first year nursing students (19 African and 31 Caucasian; age range 18-40 years)...
July 20, 2018: Skin Research and Technology
R Pimenta, P Leal-Filipe, A Oliveira
Juvenile xanthogranuloma is the most common type of non-Langerhans cell histiocytosis. It appears primarily in infancy, where its differential diagnosis includes Spitz nevus, dermal nevus and molluscum contagiosum. We report the case of a 2-year-old boy with juvenile xanthogranuloma, as diagnosed using real-time, in vivo reflectance confocal microscopy.
July 18, 2018: Skin Research and Technology
L Tognetti, E Cinotti, C Habougit, D Fiorani, F Cambazard, J L Perrot, P Rubegni
No abstract text is available yet for this article.
July 18, 2018: Skin Research and Technology
L Monteiro Rodrigues
No abstract text is available yet for this article.
August 2018: Skin Research and Technology
Enzo Berardesca, Marie Loden, Jorgen Serup, Philippe Masson, Luis Monteiro Rodrigues
BACKGROUND: Noninvasive quantification of stratum corneum water content is widely used in skin research and topical product development. METHODS: The original EEMCO guidelines on measurements of skin hydration by electrical methods and transepidermal water loss (TEWL) by evaporimeter published in 1997 and 2001 have been revisited and updated with the incorporation of recently available technologies. RESULTS: Electrical methods and open-chamber evaporimeters for measurement of TEWL are still the preferred techniques to measure the water balance in the stratum corneum...
August 2018: Skin Research and Technology
C-I Moon, O Lee
BACKGROUND/PURPOSE: The aim of this study was to evaluate skin condition, expensive equipment is required, continuous skin care is difficult. Therefore, we obtain the skin image using mobile camera, and propose a new algorithm that easily and simply extracts skin features. METHODS: We analyze skin features, extracting the wrinkle length, cell area, and the number of cells. To get accurate skin features, we obtain a new skin binary image, and apply Watershed segmentation to it...
August 2018: Skin Research and Technology
M Lee, K Won, E J Kim, J S Hwang, H K Lee
BACKGROUND/PURPOSE: The stratum corneum (SC) is the most important layer for the barrier function of skin, so investigation of the SC is very important in cosmetic and medical research. Here, we calculated the SC thickness using the depth profile of the skin's water concentration based on previously described methods, and then compared the results. METHODS: Seven Korean women in their 30s participated in this study. Raman spectroscopy was used to measure the in vivo depth profile of skin water concentration...
August 2018: Skin Research and Technology
F Lacarrubba, A E Verzì, M Ardigò, G Micali
BACKGROUND: The term balanitis includes a variety of inflammatory skin diseases involving the glans penis whose clinical diagnosis may be challenging. A biopsy is often required to obtain a definitive diagnosis, although it is barely accepted by patients. Reflectance confocal microscopy (RCM), that provides a real-time, en face imaging of the epidermis and upper dermis, is currently utilized for the diagnosis of some neoplastic and inflammatory skin diseases. The aim of this study was to analyze the RCM handheld findings of some common balanitis and to correlate them with dermatoscopy and histopathological features...
August 2018: Skin Research and Technology
G Josse, J Le Digabel, E Questel
BACKGROUND/PURPOSE: The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream. METHODS: Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Color measurements of the target lesions were performed with a chromameter and with a color-calibrated camera...
August 2018: Skin Research and Technology
M O de Melo, P M B G Maia Campos
BACKGROUND: The skin is a complex biological system and may suffer change according to the environmental factors, as higher temperatures can increase sebum excretion, presenting oiliness and acne. These alterations can persist during the aging and provoke more changes in aged skin. In this study we evaluated the mature oily skin characteristics using biophysical and skin imaging techniques. MATERIAL AND METHODS: Sixty healthy female subjects, aged between 39 and 55 years old were recruited and separated into 2 groups according to their skin type: normal/dry and oily skin...
August 2018: Skin Research and Technology
S-S Cheng, Y-L Chang, W-M Fei, W-F Zhai, H Cheng, S Yang, X-J Zhang
OBJECTIVE: The objective of this study was to make noninvasive quantitative analysis of ceramide (CER) in skin of healthy Chinese population by high performance liquid chromatography tandem mass spectrometry. METHODS: Seven healthy subjects were selected and the stratified skin samples were available using cyanoacrylate adhesion method. High performance liquid chromatography tandem mass spectrometry, use ceramide Subclass Standard C42H85NO3 Quantification of the 12 corresponding ceramide subclass in the epidermis on the 7 skin samples, which cannot get all the standard of ceramides subclass since the stratum corneum ceramide is complex and diverse...
August 2018: Skin Research and Technology
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