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Skin Research and Technology

H Yoshida, A Komiya, R Ohtsuki, A Kusaka-Kikushima, S Sakai, K Kawabata, M Kobayashi, S Nakamura, A Nagaoka, T Sayo, Y Okada, Y Takahashi
BACKGROUND: Hyaluronan (HA) is an important constituent of extracellular matrix (ECM) in the skin, and HA degradation mediated by HYBID (KIAA1199) is suggested to be implicated in facial skin wrinkling in Japanese women. Ethnic difference in skin wrinkle formation is known between Caucasian and Japanese women, but no information is available for the relations of HA and HYBID expression levels with skin wrinkling in Caucasian women. METHODS: The skin surface roughness at the eye corner of the Caucasian female subjects was measured, and the skin specimens biopsied from the same areas were subjected to microarray gene analysis, HA staining, and immunohistochemistry for HYBID...
March 14, 2018: Skin Research and Technology
L Petit, D Zugaj, V Bettoli, B Dreno, S Kang, J Tan, V Torres, A M Layton, P Martel
BACKGROUND: One major sequelae of acne is atrophic scarring, yet objective tools to assess scars are lacking. Neither depth nor volume of atrophic scars is readily evaluable clinically and standard 2D photography is significantly affected by lighting and shadows. The aim of our study was to define and evaluate parameters of 3D imaging that can be used to assess severity of atrophic acne scarring. METHODS: Single center study of 31 patients with acne scarring. A target area of 3 × 3 cm was defined on the face...
March 6, 2018: Skin Research and Technology
J Y Choi, E J Kim, S I Jang, A R Kim, T J Lee, H K Lee
BACKGROUND: Dryness-related heel skin problems are common; however, there are very few studies about heel skin dryness. The objective of this study was to develop new assessment methods for evaluating heel skin dryness, to clarify the characteristics associated with heal skin dryness, and assess the effectiveness of moisturizer use according to dryness severity. MATERIALS AND METHODS: We investigated the heel skin of 150 Korean women (aged 20-78 years). Heel skin images were taken using a DSLR camera and the distribution or severity of flakes, scaling, cracking, and fissures were visually assessed...
March 1, 2018: Skin Research and Technology
A J B Andersen, C Fuchs, M Ardigo, M Haedersdal, M Mogensen
BACKGROUND AND OBJECTIVE: Malassezia Folliculitis (MaF) is an inflammatory condition of hair follicles caused by Malassezia yeast. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are imaging technologies enabling in vivo visualization of superficial skin layers. This study explores morphology of pustules in MaF imaged by OCT and RCM. METHODS: Patients with microscopically verified MaF were included in this case series. Morphology was evaluated qualitatively with RCM and OCT, focusing on shape, border and content of selected pustules...
February 27, 2018: Skin Research and Technology
G Boyer, N Lachmann, G Bellemère, C De Belilovsky, C Baudouin
BACKGROUND: A woman's skin is dramatically affected by pregnancy. Its biomechanical properties are critical for resisting highly stressed areas. The aim of this work was to evaluate the impact of pregnancy on the mechanical properties of skin, as well as to evaluate the imprint that pregnancy leaves on the skin after delivery. MATERIALS AND METHODS: Suction tests using a cutometer were performed on 15 non-pregnant women and 26 pregnant women at 8 months of pregnancy and 4 months after delivery...
February 26, 2018: Skin Research and Technology
D J du Preez, J L du Plessis, C Y Wright
BACKGROUND: Observing accurate real-time measurements of solar ultraviolet radiation (UVR) levels is important since personal excess sun exposure is associated with skin cancers. Handheld measurement devices may be helpful but their accuracy is unknown. We compare a portable, science-grade solar UVR monitoring device against two fixed, science-grade solar UVR instruments. METHODS: Instruments were (1) a fixed Solar Light 501 UV-B biometer to measure UV-B; (2) a fixed Kipp and Zonen radiometer used to measure UV-A and UV-B; and (3) Goldilux ultraviolet probes which are commercially available portable devices...
February 23, 2018: Skin Research and Technology
C-I Moon, O Lee
BACKGROUND/PURPOSE: The aim of this study was to evaluate skin condition, expensive equipment is required, continuous skin care is difficult. Therefore, we obtain the skin image using mobile camera, and propose a new algorithm that easily and simply extracts skin features. METHODS: We analyze skin features, extracting the wrinkle length, cell area, and the number of cells. To get accurate skin features, we obtain a new skin binary image, and apply Watershed segmentation to it...
February 22, 2018: Skin Research and Technology
M Lee, K Won, E J Kim, J S Hwang, H K Lee
BACKGROUND/PURPOSE: The stratum corneum (SC) is the most important layer for the barrier function of skin, so investigation of the SC is very important in cosmetic and medical research. Here, we calculated the SC thickness using the depth profile of the skin's water concentration based on previously described methods, and then compared the results. METHODS: Seven Korean women in their 30s participated in this study. Raman spectroscopy was used to measure the in vivo depth profile of skin water concentration...
February 20, 2018: Skin Research and Technology
F Lacarrubba, A E Verzì, M Ardigò, G Micali
BACKGROUND: The term balanitis includes a variety of inflammatory skin diseases involving the glans penis whose clinical diagnosis may be challenging. A biopsy is often required to obtain a definitive diagnosis, although it is barely accepted by patients. Reflectance confocal microscopy (RCM), that provides a real-time, en face imaging of the epidermis and upper dermis, is currently utilized for the diagnosis of some neoplastic and inflammatory skin diseases. The aim of this study was to analyze the RCM handheld findings of some common balanitis and to correlate them with dermatoscopy and histopathological features...
February 18, 2018: Skin Research and Technology
G Josse, J Le Digabel, E Questel
BACKGROUND/PURPOSE: The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream. METHODS: Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Color measurements of the target lesions were performed with a chromameter and with a color-calibrated camera...
February 15, 2018: Skin Research and Technology
M O de Melo, P M B G Maia Campos
BACKGROUND: The skin is a complex biological system and may suffer change according to the environmental factors, as higher temperatures can increase sebum excretion, presenting oiliness and acne. These alterations can persist during the aging and provoke more changes in aged skin. In this study we evaluated the mature oily skin characteristics using biophysical and skin imaging techniques. MATERIAL AND METHODS: Sixty healthy female subjects, aged between 39 and 55 years old were recruited and separated into 2 groups according to their skin type: normal/dry and oily skin...
February 13, 2018: Skin Research and Technology
S-S Cheng, Y-L Chang, W-M Fei, W-F Zhai, H Cheng, S Yang, X-J Zhang
OBJECTIVE: The objective of this study was to make noninvasive quantitative analysis of ceramide (CER) in skin of healthy Chinese population by high performance liquid chromatography tandem mass spectrometry. METHODS: Seven healthy subjects were selected and the stratified skin samples were available using cyanoacrylate adhesion method. High performance liquid chromatography tandem mass spectrometry, use ceramide Subclass Standard C42H85NO3 Quantification of the 12 corresponding ceramide subclass in the epidermis on the 7 skin samples, which cannot get all the standard of ceramides subclass since the stratum corneum ceramide is complex and diverse...
February 9, 2018: Skin Research and Technology
J Danzberger, M Donovan, C Rankl, R Zhu, S Vicic, C Baltenneck, R Enea, P Hinterdorfer, G S Luengo
BACKGROUND: The glycosylation of proteins on the surface of corneocytes is believed to play an important role in cellular adhesion in the stratum corneum (SC) of human skin. Mapping with accuracy the localization of glycans on the surface of corneocytes through traditional methods of immunohistochemistry and electron microscopy remains a challenging task as both approaches lack enough resolution or need to be performed in high vacuum conditions. MATERIALS AND METHODS: We used an advanced mode of atomic force microscope (AFM), with simultaneous topography and recognition imaging to investigate the distribution of glycans on native (no chemical preparation) stripped samples of human SC...
February 7, 2018: Skin Research and Technology
M A Kim, E J Kim, H K Lee
BACKGROUND: Skin elasticity is an important indicator of skin aging. The aim of this study was to demonstrate that the SkinFibrometer® is appropriate for measuring skin biomechanical properties, and to correlate it with elasticity parameters measured using the Cutometer® and with dermis structural properties measured using DUB® Skinscanner. MATERIALS AND METHODS: Twenty-one individuals participated in this study. The skin of the cheek, around the eye, and the volar forearm were evaluated...
February 6, 2018: Skin Research and Technology
S Springer, M Zieger, U C Hipler, K König, J Lademann, M Kaatz, M J Koehler
BACKGROUND: Mucous membranes may be affected by various diseases and the diagnostic accessibility is limited. Multiphoton laser tomography (MPT) is a useful tool for in vivo evaluation of superficial skin structures and might also be useful for the imaging of mucosa. OBJECTIVES: In order to investigate the suitability of MPT for the evaluation of mucous membranes, tissue samples of different donors and anatomical localizations have been imaged. METHODS: Human mucosa samples from the urinary bladder, palatine tonsil and ocular conjunctiva were investigated by MPT and subsequently compared with conventional histology...
February 6, 2018: Skin Research and Technology
E Tamura, J Ishikawa, K Sugata, K Tsukahara, H Yasumori, T Yamamoto
BACKGROUND/AIMS: Lips can easily become dry and rough and their biggest problems are drying and chapping. The cause of those problems is considered to be that the stratum corneum (SC) moisture is small and its barrier function is low. However, those problems decrease in subjects as they approach 40 years of age, after which problems due to their shape and color increase. The purpose of this study was to investigate relationships between SC properties of the lips during aging and to clarify the cause(s) of lip problems...
February 6, 2018: Skin Research and Technology
Elena Rossi, Victor Desmond Mandel, Alessia Paganelli, Francesca Farnetani, Giovanni Pellacani
No abstract text is available yet for this article.
February 6, 2018: Skin Research and Technology
D Zugaj, A Chenet, L Petit, J Vaglio, T Pascual, C Piketty, V Bourdes
BACKGROUND: Currently, imaging technologies that can accurately assess or provide surrogate markers of the human cutaneous microvessel network are limited. Dynamic optical coherence tomography (D-OCT) allows the detection of blood flow in vivo and visualization of the skin microvasculature. However, image processing is necessary to correct images, filter artifacts, and exclude irrelevant signals. The objective of this study was to develop a novel image processing workflow to enhance the technical capabilities of D-OCT...
February 4, 2018: Skin Research and Technology
S Y Chen, J Yin, X M Wang, Y Q Liu, Y R Gao, X P Liu
BACKGROUND: Sensitive skin (SS) seems not to be a one-dimensional condition and many scholars concentrate on skin barrier disruption or sensorineural change, but few focus on its increased vascular reactivity. This study explored the possibility of using the different selection methods and measurement methods to verify a high vascular reactivity in SS without an impaired cutaneous barrier function. METHODS: Sixty "self-perceived sensitive skin" volunteers were enlisted and each one completed three kinds of screening tests: assess cutaneous sensory using questionnaire survey and Lactic Acid Sting Test (LAST); assess barrier function using Sodium lauryl sulphate (SLS) skin irritation test and assess cutaneous vascular reactivity using 98% DMSO test and non-invasive measurement...
February 2, 2018: Skin Research and Technology
A S Dugaret, B Bertino, B Gauthier, B Gamboa, M Motte, Y Rival, D Piwnica, H Osman-Ponchet, V Bourdès, J J Voegel
BACKGROUND/PURPOSE: Following intradermal injection, hyaluronic acid (HA)-based fillers tend to spread within the reticular dermis and to distribute between the dermal fibers. This biointegration is commonly measured qualitatively using histological methods. We developed a "toolbox" consisting of a visual scoring and a semi-automatic image analysis method using internal developed algorithm to quantitate the biointegration of Restylane® in histological sections. METHODS: Restylane® was injected intradermally in the abdominal skin of 10 healthy human subjects scheduled for abdominoplasty...
February 2, 2018: Skin Research and Technology
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