journal
MENU ▼
Read by QxMD icon Read
search

Clinical Reviews in Allergy & Immunology

journal
https://www.readbyqxmd.com/read/28054230/tumor-necrosis-factor-alpha-and-pregnancy-focus-on-biologics-an-updated-and-comprehensive-review
#1
REVIEW
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Elisa Llurba, Josep Maria Gris
Tumor necrosis factor-α (TNF-α) is a central regulator of inflammation, and TNF-α antagonists may be effective in treating inflammatory disorders in which TNF-α plays a major pathogenic role. TNF-α has also been associated with inflammatory mechanisms related to implantation, placentation, and pregnancy outcome. TNF-α is secreted by immune cells and works by binding to TNFR1 and TNFR2 cell receptors. TNF-α is also related to JAK/STAT pathways, which opens up hypothetical new targets for modifying. The accurate balance between Th1 cytokines, mainly TNF-α, Th17, and Th2, particularly IL-10 is essential to achieve good obstetric outcomes...
January 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28025778/role-of-mast-cells-in-the-pathogenesis-of-multiple-sclerosis-and-experimental-autoimmune-encephalomyelitis
#2
REVIEW
Daniel Elieh-Ali-Komi, Yonghao Cao
Multiple sclerosis (MS) is a neurological autoimmune disorder of the central nervous system (CNS), characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. The hallmark of the disease is the demyelinated plaque, a hypocellular area characterized by formation of astrocytic scars and infiltration of mononuclear cells. Recent studies have revealed that both innate and adaptive immune cells contribute to the pathogenesis of MS and its experimental autoimmune encephalomyelitis (EAE) model...
December 26, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28004375/gorham-stout-disease-a-clinical-case-report-and-immunological-mechanisms-in-bone-erosion
#3
REVIEW
Maria José Franco-Barrera, Maria Guadalupe Zavala-Cerna, Georgina Aguilar-Portillo, Diana Brisa Sánchez-Gomez, Olivia Torres-Bugarin, Miguel Angel Franco-Barrera, Carlos Manuel Roa-Encarnacion
Gorham-Stout disease (GSD) is a rare condition of osteolysis with excessive lymphangiogenesis within bone tissue. The etiology of this condition remains unknown but seems to affect mainly children and young adults of both genders all over the world. Unfortunately, there is no standardized method for diagnosis; however, histopathology remains as the gold standard. This condition is often misdiagnosed due to its varying clinical presentations from case-to-case. Here, we report the case of an 8-year-old girl who presented with chronic mandibular pain during mastication and received multiple antibiotic treatment due to infectious origin suspicion...
December 21, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27878451/beyond-genetics-what-causes-type-1-diabetes
#4
REVIEW
Zhen Wang, Zhiguo Xie, Qianjin Lu, Christopher Chang, Zhiguang Zhou
Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell-mediated β cell destruction in the pancreas of genetically susceptible individuals. Extensive familial and population genetic studies uncovered the strong linkage and association between HLA gene variants and T1D. Non-HLA genes have also been associated with T1D, such as INS, CTLA4, and PTPN22. T1D is considered as one of the most heritable common diseases. However, evidence that monozygotic twins have incomplete concordance of disease susceptibility provides convincing proof that environmental factors also play important roles in the pathogenesis of the disease...
November 22, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27873163/an-update-on-the-use-of-immunomodulators-in-primary-immunodeficiencies
#5
REVIEW
Pandiarajan Vignesh, Amit Rawat, Surjit Singh
The genomic revolution in the past decade fuelled by breathtaking advances in sequencing technologies has defined several new genetic diseases of the immune system. Many of these newly characterized diseases are a result of defects in genes involved in immune regulation. The discovery of these diseases has opened a vista of new therapeutic possibilities. Immunomodulatory agents, a hitherto unexplored therapeutic option in primary immunodeficiency diseases have been tried in a host of these newly described maladies...
November 21, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27377298/bacterial-and-viral-infections-in-atopic-dermatitis-a-comprehensive-review
#6
REVIEW
Peck Y Ong, Donald Y M Leung
Atopic dermatitis (AD) is the most common allergic skin disease in the general population. It is a chronic inflammatory skin disease complicated by recurrent bacterial and viral infections that, when left untreated, can lead to significant complications. The current article will review immunologic and molecular mechanisms underlying the propensity of AD patients to microbial infections. These infections include Staphylococcus aureus (S. aureus) skin infections, eczema herpeticum, eczema vaccinatum, and eczema coxsackium...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27277132/atopy-and-specific-cancer-sites-a-review-of-epidemiological-studies
#7
REVIEW
Yubao Cui, Andrew W Hill
Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27236440/zika-virus-infection-current-concerns-and-perspectives
#8
REVIEW
Mari Kannan Maharajan, Aruna Ranjan, Jian Feng Chu, Wei Lim Foo, Zhi Xin Chai, Eileen YinYien Lau, Heuy Mien Ye, Xi Jin Theam, Yen Ling Lok
The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. The aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic methods and modes of transmission of Zika virus infection, as well as potential therapeutic targets to combat microcephaly...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27122022/the-basis-of-structure-function-claims-of-nutraceuticals
#9
REVIEW
Andrea T Borchers, Carl L Keen, M Eric Gershwin
In the United States, as in most of the world, there are large numbers of nutraceuticals that are sold and which people take to boost their immune response. There are, in addition, almost an equal number of products sold to reduce allergies. However, very few consumers, and indeed physicians, are aware of what a structure/function claim is. Structure/function claims are labeling claims that can be used to describe the potential effects of a dietary ingredient or similar substance on the structure or function of the human body...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26924010/forkhead-box-o1-regulates-macrophage-polarization-following-staphylococcus-aureus-infection-experimental-murine-data-and-review-of-the-literature
#10
Yu-Chen Wang, Hong-Di Ma, Xue-Ying Yin, Yin-Hu Wang, Qing-Zhi Liu, Jing-Bo Yang, Qing-Hua Shi, Baolin Sun, M Eric Gershwin, Zhe-Xiong Lian
The functions of macrophages that lead to effective host responses are critical for protection against Staphylococcus aureus. Deep tissue-invading S. aureus initially countered by macrophages trigger macrophage accumulation and induce inflammatory responses through surface receptors, especially toll-like receptor 2 (TLR2). Here, we found that macrophages formed sporadic aggregates in the liver during infection. Within those aggregates, macrophages co-localized with T cells and were indispensable for their infiltration...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26385242/the-genetics-and-epigenetics-of-atopic-dermatitis-filaggrin-and-other-polymorphisms
#11
REVIEW
Yunsheng Liang, Christopher Chang, Qianjin Lu
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by a combination of genetic and environmental factors. Genetic evidences depict a complex network comprising by epidermal barrier dysfunctions and dysregulation of innate and adaptive immunity in the pathogenesis of AD. Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD, and other mutations associated with epidermal barriers such as SPINK5, FLG-2, SPRR3, and CLDN1 have all been linked to AD...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26142065/impact-of-immunoglobulin-therapy-in-pediatric-disease-a-review-of-immune-mechanisms
#12
REVIEW
Priscilla H Wong, Kevin M White
Intravenous immunoglobulin (IVIG) provides replacement therapy in immunodeficiency and immunomodulatory therapy in inflammatory and autoimmune diseases. This paper describes the immune mechanisms underlying six major non-primary immunodeficiency pediatric diseases and the diverse immunomodulatory functions of IVIG therapy. In Kawasaki disease, IVIG plays a major, proven, and effective role in decreasing aneurysm formation, which represents an aberrant inflammatory response to an infectious trigger in a genetically predisposed individual...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/26100618/cutaneous-manifestations-in-dermatomyositis-key-clinical-and-serological-features-a-comprehensive-review
#13
REVIEW
Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama
Dermatomyositis (DM) is a common idiopathic inflammatory myopathy. The pathogenesis is considered to be microangiopathy affecting skin and muscle. The cutaneous manifestations of DM are the most important aspect of this disease, and their correct evaluation is important for early diagnosis. The skin signs are various: Some are pathognomonic or highly characteristic, and others are compatible with DM. Recently, DM has been categorized into several disease subsets based on the various autoantibodies present in patients...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/25931325/mediators-of-chronic-pruritus-in-atopic-dermatitis-getting-the-itch-out
#14
REVIEW
Nicholas K Mollanazar, Peter K Smith, Gil Yosipovitch
For centuries, itch was categorized as a submodality of pain. Recent research over the last decade has led to the realization that itch is in fact a separate and distinct, albeit closely related, sensation. Chronic itch is a common complaint and has numerous etiologies. Various receptors (TRPA1, TRPV1, PAR2, gastrin-releasing peptide receptor (GRPR), Mas-related G proteins), secreted molecules (histamine, nerve growth factor (NGF), substance P (SP), proteases), and cytokines/chemokines (thymic stromal lymphopoietin (TSLP), IL-2, IL-4, IL-13, and IL-31) are implicated as mediators of chronic pruritus...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/25869743/treatment-of-eczema-corticosteroids-and-beyond
#15
REVIEW
Melanie Chong, Luz Fonacier
Atopic dermatitis (AD) is a chronic inflammatory skin condition that requires a manifold approach to therapy. The goal of therapy is to restore the function of the epidermal barrier and to reduce skin inflammation. This can be achieved with skin moisturization and topical anti-inflammatory agents, such as topical corticosteroids and calcineurin inhibitors. Furthermore, proactive therapy with twice weekly use of both topical corticosteroids and calcineurin inhibitors in previously affected areas has been found to reduce the time to the next eczematous flare...
December 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27459852/hae-pathophysiology-and-underlying-mechanisms
#16
REVIEW
Bruce L Zuraw, Sandra C Christiansen
Remarkable progress in understanding the pathophysiology and underlying mechanisms of hereditary angioedema has led to the development of effective treatment for this disorder. Progress in three separate areas has catalyzed our understanding of hereditary angioedema. The first is the recognition that HAE type I and type II result from a deficiency in the plasma level of functional C1 inhibitor. This observation has led to a detailed understanding of the SERPING1 mutations responsible for this deficiency as well as the molecular regulation of C1 inhibitor expression and function...
October 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27388236/the-humanistic-societal-and-pharmaco-economic-burden-of-angioedema
#17
REVIEW
Hilary Longhurst, Anette Bygum
Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disorder characterized by intermittent and unpredictable episodes of swelling which cause disfigurement, disability, pain, or, in case of laryngeal swelling, risk of death. Historical factors, including the intermittent nature of the disorder, the lack of awareness of this ultra-rare condition amongst medical personnel, lack of specialist centers, and limited treatment options have contributed to under-diagnosis and under-treatment of the condition...
October 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27300248/the-effect-of-tnf-inhibitors-on-cardiovascular-events-in-psoriasis-and-psoriatic-arthritis-an-updated-meta-analysis
#18
Zheng-Sheng Yang, Ning-Ning Lin, Li Li, Yang Li
TNF inhibitors have been used in psoriasis (Pso) and psoriatic arthritis (PsA), which were associated with increased risk of cardiac and cerebrovascular events. However, whether TNF inhibitors reduce cardiovascular event is still unclear. Therefore, we aimed to evaluate the effect of TNF inhibitors on adverse cardiovascular events (CVEs) in Pso with or without PsA. We undertook a meta-analysis of clinical trials identified in systematic searches of MEDLINE, EMBASE, Wanfang database, Cochrane Database, and Google scholar through December 31, 2015...
October 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27287037/the-story-of-angioedema-from-quincke-to-bradykinin
#19
REVIEW
Avner Reshef, Mona Kidon, Iris Leibovich
The term "swelling" has been used in the old scriptures to illustrate a change of normal figure and, as such, an expression of illness. It should be noted that in ancient times, human diseases were very often regarded a punishment from God. Hence, it is not surprising that one of the oldest tests for infidelity involved swelling as an inflicted punishment. The great Greek physician Hippocrates (377-460 BC), considered one of the most outstanding figures in the history of medicine and "Father of the Western Medicine," already used the term oídēma to describe swelling of organs...
October 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27273087/complement-kinins-and-hereditary-angioedema-mechanisms-of-plasma-instability-when-c1-inhibitor-is-absent
#20
REVIEW
Allen P Kaplan, Kusumam Joseph
Plasma of patients with types I and II hereditary angioedema is unstable if incubated in a plastic (i.e., inert) vessel at 37 °C manifested by progressively increasing formation of bradykinin. There is also a persistent low level of C4 in 95 % of patients even when they are symptomatic. These phenomena are due to the properties of the C1r subcomponent of C1, factor XII, and the bimolecular complex of prekallikrein with high molecular weight kininogen (HK). Purified C1r auto-activates in physiologic buffers, activates C1s, which in turn depletes C4...
October 2016: Clinical Reviews in Allergy & Immunology
journal
journal
32191
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"