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Journal of the International Neuropsychological Society: JINS

Cutter A Lindbergh, Catherine M Mewborn, Billy R Hammond, Lisa M Renzi-Hammond, Joanne M Curran-Celentano, L Stephen Miller
OBJECTIVES: It is well known that the carotenoids lutein (L) and zeaxanthin (Z) improve eye health and an accumulating evidence base suggests cognitive benefits as well. The present study investigated underlying neural mechanisms using functional magnetic resonance imaging (fMRI). It was hypothesized that lower L and Z concentrations would be associated with neurobiological inefficiency (i.e., increased activation) during cognitive performance. METHODS: Forty-three community-dwelling older adults (mean age=72 years; 58% female; 100% Caucasian) were asked to learn and recall pairs of unrelated words in an fMRI-adapted paradigm...
October 25, 2016: Journal of the International Neuropsychological Society: JINS
Siddharth Ramanan, Maxime Bertoux, Emma Flanagan, Muireann Irish, Olivier Piguet, John R Hodges, Michael Hornberger
OBJECTIVES: With comparable baseline performance on executive functions (EF) and memory between Alzheimer's disease (AD) and behavioral-variant frontotemporal dementia (bvFTD), it is currently unclear if both diseases can be distinguished longitudinally on these measures reliably. METHODS: A total of 111 participants (33 AD, 31 bvFTD, and 47 controls) were followed-up annually over a 4-year period and tested on measures of EF, memory, and orientation. Linear mixed-effect models were constructed using disease severity as a nuisance variable to examine profiles of neuropsychological performance decline...
October 18, 2016: Journal of the International Neuropsychological Society: JINS
Eleni Demetriou, Roee Holtzer
OBJECTIVES: Mild cognitive impairments (MCI) is a transitional state in aging associated with increased risk of incident dementia. The current study investigated whether MCI status moderated the effect of time on word generation during verbal fluency tasks. Specifically, the objective was to determine whether MCI status had differential effects on initial automatic or latter more effortful retrieval processes of fluency tasks. METHODS: Participants were community residing older adults enrolled in a longitudinal cohort study...
October 17, 2016: Journal of the International Neuropsychological Society: JINS
Allison R Kaup, Carrie Peltz, Kimbra Kenney, Joel H Kramer, Ramon Diaz-Arrastia, Kristine Yaffe
OBJECTIVES: The aim of this study was to characterize the neuropsychological profile of lifetime traumatic brain injury (TBI) in older Veterans. METHODS: Participants were 169 older Veterans [mean age=79.1 years (range, 51-97 years), 89% male, 92% Caucasian], 88 with lifetime TBI and 81 without TBI, living in Veterans' retirement homes in independent residence. TBI history was ascertained with the Ohio State TBI Identification Method structured interview. Cognition was assessed with neuropsychological tests: Raw scores were converted to Z-scores compared to age-corrected normative data and combined into five domain composite Z-scores (attention/working memory, learning/memory, language, processing speed, executive functioning)...
October 4, 2016: Journal of the International Neuropsychological Society: JINS
Mark D McCurdy, Elise M Turner, Lamia P Barakat, Wendy L Hobbie, Janet A Deatrick, Iris Paltin, Michael J Fisher, Matthew C Hocking
OBJECTIVES: Treatments for childhood brain tumors (BT) confer substantial risks to neurological development and contribute to neuropsychological deficits in young adulthood. Evidence suggests that individuals who experience more significant neurological insult may lack insight into their neurocognitive limitations. The present study compared survivor, mother, and performance-based estimates of executive functioning (EF), and their associations with treatment intensity history in a subsample of young adult survivors of childhood BTs...
September 26, 2016: Journal of the International Neuropsychological Society: JINS
Mohammed K Shakeel, Nancy M Docherty, Patrick R Rich, Maria S Zaragoza, Quin M Chrobak, Amanda McCleery
OBJECTIVES: Confabulations occur in schizophrenia and certain severe neuropsychiatric conditions, and to a lesser degree in healthy individuals. The present study used a forced confabulation paradigm to assess differences in confabulation between schizophrenia patients and healthy controls. METHODS: Schizophrenia patients (n=60) and healthy control participants (n=19) were shown a video with missing segments, asked to fill in the gaps with speculations, and tested on their memory for the story...
September 22, 2016: Journal of the International Neuropsychological Society: JINS
Lori J P Altmann, Elizabeth Stegemöller, Audrey A Hazamy, Jonathan P Wilson, Dawn Bowers, Michael S Okun, Chris J Hass
OBJECTIVES: Parkinson's disease (PD) results in a range of non-motor deficits that can affect mood, cognition, and language, and many of these issues are unresponsive to pharmacological intervention. Aerobic exercise can improve mood and cognition in healthy older adults, although only a few studies have examined exercise effects on these domains in PD. The current study assesses the effects of aerobic exercise on aspects of cognition, mood, and language production in people with PD. METHODS: This study compares the effects of aerobic exercise to stretch-balance training and a no-contact control group in participants with idiopathic PD...
September 22, 2016: Journal of the International Neuropsychological Society: JINS
Sarah Raz, Jamie C Piercy, Andrew M Heitzer, Brittany N Peters, Julie Bapp Newman, Angela K DeBastos, Noa Ofen, Beau Batton, Daniel G Batton
OBJECTIVES: A limited body of research is available on the relationships between multiplicity of birth and neuropsychological functioning in preterm children who were conceived in the age of assisted reproductive technology and served by the modern neonatal intensive care unit. Our chief objective was to evaluate whether, after adjustment for sociodemographic factors and perinatal complications, twin birth accounted for a unique portion of developmental outcome variance in children born at-risk in the surfactant era...
October 2016: Journal of the International Neuropsychological Society: JINS
Eben S Schwartz, Laszlo Erdodi, Nicholas Rodriguez, Jyotsna J Ghosh, Joshua R Curtain, Laura A Flashman, Robert M Roth
OBJECTIVES: The Forced Choice Recognition (FCR) trial of the California Verbal Learning Test, 2nd edition, was designed as an embedded performance validity test (PVT). To our knowledge, this is the first systematic review of classification accuracy against reference PVTs. METHODS: Results from peer-reviewed studies with FCR data published since 2002 encompassing a variety of clinical, research, and forensic samples were summarized, including 37 studies with FCR failure rates (N=7575) and 17 with concordance rates with established PVTs (N=4432)...
September 2016: Journal of the International Neuropsychological Society: JINS
Coco O Bernard, Jennie A Ponsford, Audrey McKinlay, Dean McKenzie, David Krieser
OBJECTIVES: A notable minority of children will experience persistent post-concussive symptoms (PCS) following mild traumatic brain injury (mTBI), likely maintained by a combination of injury and non-injury related factors. Adopting a prospective longitudinal design, this study aimed to investigate the relative influence of child, family, and injury factors on both acute and persistent PCS in young children. METHODS: Participants were 101 children aged 2-12 who presented to an Emergency Department, with either mTBI or minor bodily trauma (control)...
September 2016: Journal of the International Neuropsychological Society: JINS
Rachel M Wasserman, Grayson N Holmbeck
OBJECTIVES: The current study examined neuropsychological performance among children with spina bifida (SB) to determine biological and functional correlates of distinct "profiles" of cognitive functioning. METHODS: A total of 95 children with SB myelomeningocele (ages, 8-15 years) completed a neuropsychological assessment battery. Hierarchical and non-hierarchical cluster analyses were used to identify and confirm a cluster solution. Hypothesized predictors of cluster membership included lesion level, number of shunt surgeries, history of seizures, age, ethnicity, socio-economic status, and family stress...
September 2016: Journal of the International Neuropsychological Society: JINS
Gemma L McKeon, James G Scott, Donna M Spooner, Alexander E Ryan, Stefan Blum, David Gillis, Daman Langguth, Gail A Robinson
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently described life-threatening autoimmune disorder associated with a characteristic multi-stage neuropsychiatric syndrome. Although it is known that the majority of patients experience neuropsychological disturbance post-treatment, some aspects of the cognitive profile remain unclear. METHODS: This study sought to investigate patterns of cognitive functioning in a sample of anti-NMDAR encephalitis patients...
September 2016: Journal of the International Neuropsychological Society: JINS
Noah D Silverberg, William Panenka, Grant L Iverson, Jeffrey R Brubacher, Jason R Shewchuk, Manraj K S Heran, Gary C S Oh, William G Honer, Rael T Lange
OBJECTIVES: To examine the effect of pre-injury alcohol use, acute alcohol intoxication, and post-injury alcohol use on outcome from mild to moderate traumatic brain injury (TBI). METHODS: Prospective inception cohort of patients who presented to the Emergency Department with mild to moderate TBI and had a blood alcohol level (BAL) taken for clinical purposes. Those who completed the 1-year outcome assessment were eligible for this study (N=91). Outcomes of interest were the count of post-concussion symptoms (British Columbia Post-Concussion Symptom Inventory), low neuropsychological test scores (Neuropsychological Assessment Battery), and abnormal regions of interest on diffusion tensor imaging (low fractional anisotropy)...
September 2016: Journal of the International Neuropsychological Society: JINS
Jonathan J Mietchen, David P Bennett, Trevor Huff, Dawson W Hedges, Shawn D Gale
OBJECTIVES: Evaluate the association between pediatric sleep-disordered breathing (SDB) and executive functioning. METHODS: We searched multiple electronic databases for peer-reviewed journal articles related to pediatric SDB and executive functioning. We included studies that assessed SDB via polysomnography, included objective or questionnaire measures of executive function, and had an age-matched control group. Fourteen articles met inclusion criteria with a total sample of 1697 children ages 5 to 17 years (M=9...
September 2016: Journal of the International Neuropsychological Society: JINS
Amery Treble-Barna, Huaiyu Zang, Nanhua Zhang, Lisa J Martin, Keith Owen Yeates, H Gerry Taylor, Shari L Wade, Brad G Kurowski
OBJECTIVES: To examine whether apolipoprotein e4 (APOE) status moderates the association of family environment with child functioning following early traumatic brain injury (TBI). METHODS: Sixty-five children with moderate to severe TBI and 70 children with orthopedic injury (OI) completed assessments 6, 12, 18 months, and 3.5 and 6.8 years post injury. DNA was extracted from saliva samples and genotyped for APOE e4 status. Linear mixed models examined moderating effects of APOE e4 status on associations between two family environment factors (parenting style, home environment) and three child outcomes (executive functioning, behavioral adjustment, adaptive functioning)...
September 2016: Journal of the International Neuropsychological Society: JINS
Mary R Newsome, Andrew R Mayer, Xiaodi Lin, Maya Troyanskaya, George R Jackson, Randall S Scheibel, Annette Walder, Ajithraj Sathiyaraj, Elisabeth A Wilde, Shalini Mukhi, Brian A Taylor, Harvey S Levin
No abstract text is available yet for this article.
August 2016: Journal of the International Neuropsychological Society: JINS
Sara Coelho, Manuela Guerreiro, Catarina Chester, Dina Silva, João Maroco, Miguel Coelho, Fabio Paglieri, Alexandre de Mendonça
OBJECTIVES: Patients with mild cognitive impairment (MCI) may have difficulties in time perception, which in turn might contribute to some of their symptoms, especially memory deficits. The aim of this study was to evaluate perception of interval length and subjective passage of time in MCI patients as compared to healthy controls. METHODS: Fifty-five MCI patients and 57 healthy controls underwent an experimental protocol for time perception on interval length, a questionnaire for the subjective passage of time and a neuropsychological evaluation...
August 2016: Journal of the International Neuropsychological Society: JINS
Raquel Lemos, Isabel Santana, Gina Caetano, Inês Bernardino, Ricardo Morais, Reza Farivar, Miguel Castelo-Branco
OBJECTIVES: Mild cognitive impairment (MCI) has been associated with a high risk of conversion to Alzheimer's dementia. In addition to memory complaints, impairments in the visuospatial domain have been reported in this condition. We have previously shown that deficits in perceiving structure-from-motion (SFM) objects are reflected in functional reorganization of brain activity within the visual ventral stream. Here we aimed to identify structural correlates of psychophysical complex face and object recognition performance in amnestic MCI patients (n=30 vs...
August 2016: Journal of the International Neuropsychological Society: JINS
Arianna Rigon, Michelle W Voss, Lyn S Turkstra, Bilge Mutlu, Melissa C Duff
OBJECTIVES: Although it has been well documented that traumatic brain injury (TBI) can result in communication impairment, little work to date has examined the relationship between social communication skills and structural brain integrity in patients with TBI. The aim of the current study was to investigate the association between self- and other-perceived communication problems and white matter integrity in patients with mild to severe TBI. METHODS: Forty-four individuals (TBI=24) and people with whom they frequently communicate, as well as demographically matched normal healthy comparisons (NC) and their frequent communication partners, were administered, respectively, the La-Trobe Communication Questionnaire Self form (LCQ-SELF) and Other form (LCQ-OTHER)...
August 2016: Journal of the International Neuropsychological Society: JINS
J Cobb Scott, Steven Paul Woods, Kristen M Wrocklage, Brian C Schweinsburg, Steven M Southwick, John H Krystal
OBJECTIVES: Neuropsychological studies of posttraumatic stress disorder (PTSD) have revealed deficits in attention/working memory, processing speed, executive functioning, and retrospective memory. However, little is known about prospective memory (PM) in PTSD, a clinically relevant aspect of episodic memory that supports the encoding and retrieval of intentions for future actions. METHODS: Here we examined PM performance in 40 veterans with PTSD compared to 38 trauma comparison (TC) veterans who were exposed to combat but did not develop PTSD...
August 2016: Journal of the International Neuropsychological Society: JINS
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