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European Addiction Research

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https://www.readbyqxmd.com/read/29339656/new-the-european-addiction-research-award
#1
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January 16, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29339652/smoking-and-promoter-specific-deoxyribonucleic-acid-methylation-of-the-atrial-natriuretic-peptide-gene-methylation-of-smokers-and-non-smokers-differs-significantly-during-withdrawal
#2
Alexander Glahn, Mathias Rhein, Helge Frieling, Rilana Schuster, Alain El Aissami, Stefan Bleich, Thomas Hillemacher, Marc Muschler
BACKGROUND: Atrial natriuretic peptide (ANP) is well known in psychiatric disorders to modulate hypothalamic-pituitary-adrenal axis activity. Disturbances of ANP have been described in early abstinent alcohol-dependent patients. This is the first longitudinal investigation on cytosine-phosphatidyl-guanine (CpG)-island promoter methylation of the ANP gene in the blood of tobacco-dependent patients. METHODS: In a longitudinal approach, we investigated whether changes in ANP serum levels correlated to CpG methylation of the respective gene promoters on days 1, 7, and 14 of tobacco withdrawal...
January 16, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29320768/attention-deficit-hyperactivity-disorder-symptoms-are-common-in-patients-in-opioid-maintenance-treatment
#3
Kristine Fiksdal Abel, Edle Ravndal, Thomas Clausen, Jørgen G Bramness
INTRODUCTION AND AIMS: Knowledge of attention deficit hyperactivity disorder (ADHD) symptoms among patients in opioid maintenance treatment (OMT) is important for treatment optimization and yet limited. We investigated the prevalence of ADHD symptoms, and factors associated with high ADHD symptom burden in a group of Norwegian OMT patients. METHODS: We interviewed individuals entering OMT across Norway in 2 steps between 2012 and 2016. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS; n = 175)...
January 10, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29275419/family-related-stress-versus-external-stressors-differential-impacts-on-alcohol-and-illicit-drug-use-in-young-men
#4
Ansgar Rougemont-Bücking, Veronique S Grazioli, Jean-Bernard Daeppen, Gerhard Gmel, Joseph Studer
Intense stress increases substance use (SU). However, little is known about the extent to which distinctive forms of stress should be weighted with regard to their effects on SU. This study aimed to determine whether family-related stress factors (FSF) influenced SU in a different way than external stress factors (ESF). Data was drawn from a Swiss cohort study on SU risk factors (C-SURF), involving 5,308 young adult men. Twelve month use of alcohol and of illicit substances was assessed. FSF and ESF for the time period preceding SU were measured...
December 22, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29268271/cognitive-functioning-in-formerly-opioid-dependent-adults-after-at-least-1-year-of-abstinence-a-naturalistic-study
#5
Peggy Schmidt, Annina Haberthür, Michael Soyka
This study is an evaluation of cognitive functioning in formerly opioid-dependent adults after at least 1 year of abstinence. Participants (45 formerly opioid-dependent patients, referred to as abstainers, and 45 matched healthy controls) completed a structured screening and subsequent cognitive test battery covering intelligence, learning and memory, attention, and executive functions. Many cognitive functions were comparable between long-term abstainers and healthy controls, and we found few relevant differences...
December 21, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29268270/fatal-overdoses-of-opioids-in-israel-2005-2014
#6
Daniel Feingold, Nehama Goldberger, Ziona Haklai, Shaul Lev-Ran
AIMS: To explore previously unreported rates and trends in opioid-related mortality in Israel, 2005-2014. METHODS: Data was obtained from the national database on causes of death. Drug poisoning deaths were divided into opioid-related deaths and deaths related to other drugs according to International Classification of Diseases (ICD)-10 code of underlying cause, and included drug poisoning of accidental, intentional or undetermined intent. Age-adjusted rates were calculated per 100,000 population...
December 21, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29224006/epigenetic-regulation-of-the-promotor-region-of-vascular-endothelial-growth-factor-a-and-nerve-growth-factor-in-opioid-maintained-patients
#7
Adrian Groh, Kirsten Jahn, Alexandra Burkert, Alexandra Neyazi, Laura Schares, Eva Janke, Marie Rehme, Rilana Schuster, Thomas Hillemacher, Stefan Bleich, Helge Frieling, Annemarie Heberlein
AIMS: The nerve growth factor (NGF) and the vascular endothelial growth factor-A (VEGF-A) may be of importance for psychiatric diseases including substance use disorders. The aim of the study was to identify differences in the regulation of both neuropeptides via the DNA-methylation status of the promotor regions of NGF and VEGF-A in different forms of maintenance therapy for opioid dependence and the related stress regulation via the hypothalamic-pituitary-adrenal axis. METHODS: We compared methylation levels of opioid-dependent patients receiving treatment with diamorphine (n = 28) or levomethadone (n = 54) and similar levels in a healthy control group (n = 72)...
December 8, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29224000/the-depression-anxiety-and-stress-scale-dass-21-as-a-screener-for-depression-in-substance-use-disorder-inpatients-a-pilot-study
#8
Ilse N Beaufort, Gerdien H De Weert-Van Oene, Victor A J Buwalda, J Rob J de Leeuw, Anna E Goudriaan
Depression is a common co-morbid disorder in substance use disorder (SUD) patients. Hence, valid instruments are needed to screen for depression in this subpopulation. In this study, the predictive validity of the Depression, Anxiety and Stress Scale (DASS-21) for the presence of a depressive disorder was investigated in SUD inpatients. Furthermore, differences between DASS-21 scores at intake and those recorded one week after inpatient detoxification were assessed in order to determine the measurement point of the assessment of the DASS-21 leading to the best predictive validity...
December 8, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29161720/development-of-ostqol-a-measure-of-quality-of-life-for-patients-in-opioid-substitution-treatment
#9
Lisa Strada, Gabriele Helga Franke, Bernd Schulte, Jens Reimer, Uwe Verthein
BACKGROUND: Quality of life (QOL) of patients in opioid substitution treatment (OST) is increasingly being addressed in research. However, no disease- or treatment-specific instrument is available to assess the QOL of this target population. The purpose of this project was to develop the first QOL instrument for OST patients. METHODS: Focus groups with 60 OST patients were analyzed using thematic analysis to elicit key QOL themes as perceived by patients. Identified themes were developed into items and refined through pilot testing and cognitive debriefing...
November 21, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28982095/predictors-of-persistence-of-risky-drinking-in-adults-an-11-year-follow-up-study
#10
Janne Härkönen, Mauri Aalto, Jaana Suvisaari, Tomi Lintonen, Tomi Mäki-Opas, Sebastian Peña, Pia Mäkelä
AIM: To examine the long-term predictors of persistence of risky drinking in a baseline group of risky drinkers in whom alcohol use disorder had not been diagnosed. METHODS: The data was derived from a representative sample of the Finnish adult population aged 30 years or more, surveyed at 2 time points in the years 2000 (n = 5,726) and 2011 (n = 3,848, 67.2% of the baseline sample). Risky drinking was defined using BSQF-measurement (for men, 21 standard UK drinks or more per week; for women 14+ drinks) and not having alcohol abuse or alcohol dependence...
October 6, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28934736/reduced-drinking-in-alcohol-dependence-treatment-what-is-the-evidence
#11
Karl Mann, Henri-Jean Aubin, Katie Witkiewitz
Abstinence from alcohol has been the prevailing treatment goal for individuals with alcohol dependence (AD) within the context of specialty alcohol treatment. Yet, alcohol use has been conceptualized as existing on a continuum. Importantly, most people who meet criteria for AD and could benefit from treatment never receive treatment. About half of these individuals do not seek treatment because they report a desire to continue drinking. To increase acceptability of treatment, reductions in alcohol consumption have been examined as alternative outcomes in treatment trials for AD...
September 22, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28898879/comparison-of-clomethiazole-and-diazepam-in-the-treatment-of-alcohol-withdrawal-syndrome-in-clinical-practice
#12
Hannah Sychla, Gerhard Gründer, Sarah Edith Lammertz
BACKGROUND: The objective of this retrospective study was to compare the effectivity and tolerability of diazepam and clomethiazole in the treatment of alcohol withdrawal syndrome (AWS) in a large clinical sample. METHODS: The data of 566 patients admitted to an intensive care psychiatric unit in Germany (2010-2014) were evaluated. The course of withdrawal was analyzed on a matched sample (n = 152) consisting of a diazepam group (n = 76) and a clomethiazole group (n = 76)...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28877518/naltrexone-in-the-treatment-of-broadly-defined-behavioral-addictions-a-review-and-meta-analysis-of-randomized-controlled-trials
#13
Fayçal Mouaffak, Claudio Leite, Sonia Hamzaoui, Amine Benyamina, Xavier Laqueille, Oussama Kebir
INTRODUCTION: Broadly defined behavioral addiction is a conceptual framework including behaviors characterized by loss of control and continuation despite significant negative consequences. Broadly defined behavioral addictions share many similarities with substance use disorders. As naltrexone is one of the most studied treatment for substance use disorders, we conducted a meta-analysis of randomized placebo-controlled trials (RCT) assessing the effectiveness of naltrexone in the treatment of broadly defined behavioral addictions...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28866664/smoking-trajectories-during-the-perinatal-period-and-their-risk-factors-the-nationally-representative-french-elfe-etude-longitudinale-fran%C3%A3-aise-depuis-l-enfance-birth-cohort-study
#14
Fabienne El-Khoury, Anne-Laure Sutter-Dallay, Judith Van Der Waerden, Pamela Surkan, Silvia Martins, Katherine Keyes, Blandine de Lauzon-Guillain, Marie-Aline Charles, Maria Melchior
BACKGROUND: In France, rates of perinatal smoking are among the highest worldwide; however, perinatal smoking trajectories and associated factors have still not been adequately researched. METHODS: Among women participating in the French nationally representative etude longitudinale française depuis l'enfance birth cohort (n = 15,540), perinatal smoking trajectories were estimated using group-based modelling. Associated characteristics were studied using multinomial logistic regression...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28848170/synthetic-cannabinoid-use-in-a-psychiatric-patient-population-a-pilot-study
#15
Stella Welter, Caroline Lücke, Alexandra Philomena Lam, Christina Custal, Sebastian Moeller, Peter Sörös, Christiane M Thiel, Alexandra Philipsen, Helge H O Müller
BACKGROUND: Consumption of natural cannabis (NC) and synthetic cannabinoids (SCs) has been associated with psychotic disorders. We compared the prevalence of use, consumer profiles, and psychosis-inducing potential of NC and SCs in a specific high-risk population. METHODS: This prospective pilot study included 332 patients (18-64 years, mean 36.83, SD 13.33). Patients' sociodemographics and medical histories as well as illicit substance use and psychiatric symptom histories were collected using a drug consumption survey that assessed the use of new psychoactive substances and the Psychotic Symptoms Interview...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28803249/a-brief-outline-of-the-use-of-new-technologies-for-treating-substance-use-disorders-in-the-european-union
#16
GianLuca Quaglio, Arnt Schellekens, Matthijs Blankers, Eva Hoch, Theodoros Karapiperis, Giovanni Esposito, Helmut Brand, David Nutt, Falk Kiefer
BACKGROUND: Clinicians in the field of drug addiction have started to exploit the growth of Technology-Based Interventions (TBIs). However, there is little information on how health personnel evaluate them. METHODS: Semi-structured interviews were conducted among 20 European experts. RESULTS: All of the interviewees recognised TBIs as a valuable tool to improve the management of substance-use disorders (SUDs). Most interviewees indicated that combining both traditional face-to-face therapist-patient clinic appointment with TBIs is probably the most effective method...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28797002/is-medicine-use-for-nervousness-associated-with-adolescent-at-risk-or-problem-gambling
#17
Natale Canale, Alessio Vieno, Joël Billieux, Giacomo Lazzeri, Patrizia Lemma, Massimo Santinello
OBJECTIVE: To examine the association between adolescent at-risk or problem gambling (ARPG) and medicine used to treat nervousness in a large-scale nationally representative sample of Italian adolescents. STUDY DESIGN: Data from the 2013/2014 Health Behaviour in School-aged Children Survey was used for cross-sectional analyses (a sample of 20,791 15-year-old students). Self-administered questionnaires were completed by a representative sample of high-school students...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28641297/factor-analysis-and-psychometric-properties-of-the-minnesota-nicotine-withdrawal-scale-and-the-minnesota-nicotine-withdrawal-scale-revised-italian-version
#18
Andrea Svicher, Agnese Beghè, Giacomo Mangiaracina, Fiammetta Cosci
BACKGROUND/AIMS: We run Exploratory and Confirmatory Factor Analyses of the Minnesota Nicotine Withdrawal Scale (MNWS) and of the MNWS-Revised (MNWS-R). Psychometric properties were also explored. METHODS: Adult Italian smokers, 366 in all, were assessed via the MNWS-R together with rating scales measuring cigarette dependence, alcohol use, anxiety sensitivity and negative affect at baseline and after 3 months. RESULTS: The MNWS showed good psychometric properties (α = 0...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28641293/measuring-concurrent-polydrug-use-in-general-populations-a-critical-assessment
#19
Karoliina Karjalainen, Kristiina Kuussaari, Kati Kataja, Christoffer Tigerstedt, Pekka Hakkarainen
BACKGROUND/AIMS: Polydrug use is a complicated phenomenon that is measured in a wide variety of different ways. Using Finland as an example, we aimed to demonstrate how the prevalence and prevalence trends of concurrent polydrug use (CPU) varied in the general population based on the different measurements used. METHODS: Population-based Drug Surveys conducted every 4 years during 1998-2014 were used. CPU was measured with different measurements: strict, medial and loose definition of CPU, which were based on different combinations of alcohol, illicit drugs, pharmaceutical drugs and cigarettes used during the last 12 months/30 days...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28618425/electronic-cigarettes-in-germany-patterns-of-use-and-perceived-health-improvement
#20
Kirsten Lehmann, Silke Kuhn, Jens Reimer
AIMS: The aim of the study was to characterize e-cigarette users in terms of their consumption patterns, motives, and the perceived health benefits they experience from using e-cigarettes. DESIGN: The study was a cross-sectional online survey in 2015. A total of 3,320 German e-cigarette users were enrolled. A total of 91.5% were former tobacco smokers, 7.5% used both e-cigarettes and tobacco products, 1.0% were never-smokers. RESULTS: No differences were found between ex-smokers and dual users with regard to sociodemographic and smoking history (mean age 40...
2017: European Addiction Research
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