journal
MENU ▼
Read by QxMD icon Read
search

Current Oncology

journal
https://www.readbyqxmd.com/read/28490940/systemic-therapy-in-the-curative-treatment-of-head-and-neck-squamous-cell-cancer-cancer-care-ontario-clinical-practice-guideline
#1
E Winquist, C Agbassi, B M Meyers, J Yoo, K K W Chan
OBJECTIVE: The aim of the present work was to make recommendations about the use of systemically administered drugs in combination or in sequence with radiation (rt) or surgery, or both, for cure or organ preservation, or both, in patients with locally advanced nonmetastatic (stages iii-ivb) squamous cell carcinoma of the head and neck (lascchn). METHODS: The Meta-analysis of Chemotherapy in Head and Neck Cancer (mach-nc) reports have, de facto, guided practice since 2000, and so we searched the literature for systematic reviews published from January 2000 to February 2015 in reference to five research questions...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490939/measuring-quality-care-in-localized-renal-cell-cancer-use-of-appropriate-preoperative-investigations-in-a-population-based-cohort
#2
N Moideen, K H Marzouk, K J Matheson, L A Wood
INTRODUCTION: Obtaining appropriate preoperative risk-specific staging investigations for localized renal cell carcinoma (rcc) is a recognized quality indicator. The goal of the present work was to determine the use and appropriateness of preoperative investigations in patients undergoing curative surgery for rcc. METHODS: This population-based retrospective study of patients having surgery for localized rcc recorded the use of preoperative imaging and laboratory investigations within 6 months of surgery...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490938/comparative-survival-in-patients-with-brain-metastases-from-non-small-cell-lung-cancer-treated-before-and-after-implementation-of-radiosurgery
#3
J N Greenspoon, P M Ellis, G Pond, S Caetano, J Broomfield, A Swaminath
INTRODUCTION: Survival after a diagnosis of brain metastasis in non-small-cell lung cancer (nsclc) is generally poor. We previously reported a median survival of approximately 4 months in a cohort of patients treated with whole-brain radiotherapy (wbrt). Since that time, we implemented a program of stereotactic radiosurgery (srs). In the present study, we examined survival and prognostic factors in a consecutive cohort of patients after the introduction of the srs program. METHODS: Data from a retrospective review of 167 nsclc patients with brain metastasis referred to a tertiary cancer centre during 2010-2012 were compared with data from a prior cohort of 91 patients treated during 2005-2007 ("pre-srs cohort")...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490937/uptake-of-a-21-gene-expression-assay-in-breast-cancer-practice-views-of-academic-and-community-based-oncologists
#4
M A O'Brien, S Dhesy-Thind, C Charles, M Hammond Mobilio, N B Leighl, E Grunfeld
PURPOSE: Advances in personalized medicine have produced novel tests and treatment options for women with breast cancer. Relatively little is known about the process by which such tests are adopted into oncology practice. The objectives of the present study were to understand the experiences of medical oncologists with multigene expression profile (gep) tests, including their adoption into practice in early-stage breast cancer, and the perceptions of the oncologists about the influence of test results on treatment decision-making...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490936/rising-rates-of-colorectal-cancer-among-younger-iranians-is-diet-to-blame
#5
S Hessami Arani, M A Kerachian
BACKGROUND: Colorectal cancer (crc) is one of the most prevalent cancers in the world. Although the incidence of crc is currently very low in the older Iranian population compared with Western populations, young Iranians show a rising trend of crc-that is, the age-adjusted rate is close in the young Iranian population compared with the U.S. population, and the rate in older Iranians is much lower. METHODS: To assess a putative relationship between diet and a rising rate of crc in younger Iranians, a combined text word and mesh heading search strategy identified relevant studies through Google Scholar and medline...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490935/characteristics-predicting-outcomes-of-allogeneic-stem-cell-transplantation-in-relapsed-acute-myelogenous-leukemia
#6
J Frazer, S Couban, S Doucette, S Shivakumar
BACKGROUND: Allogeneic hematopoietic stem-cell transplantation (ahsct) is associated with significant morbidity and mortality, but it can cure carefully selected patients with acute myeloid leukemia (aml) in second remission (cr2). In a cohort of patients with aml who underwent ahsct in cr2, we determined the pre-transplant factors that predicted for overall survival (os), relapse, and non-relapse mortality. We also sought to validate the prognostic risk groups derived by Michelis and colleagues in this independent population...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490934/factors-influencing-treatment-selection-and-survival-in-advanced-lung-cancer
#7
S Tabchi, E Kassouf, M Florescu, M Tehfe, N Blais
PURPOSE: Despite numerous breakthrough therapies, inoperable lung cancer still places a heavy burden on patients who might not be candidates for chemotherapy. To identify potential candidates for the newly emerging immunotherapy-based treatment paradigms, we explored the clinical and biologic factors affecting treatment decisions. METHODS: We retrospectively reviewed the records of patients diagnosed at our university-affiliated cancer centre between 1 January 2011 and 31 December 2013...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490933/prognostic-and-predictive-value-of-low-estrogen-receptor-expression-in-breast-cancer
#8
A Bouchard-Fortier, L Provencher, C Blanchette, C Diorio
PURPOSE: Anti-hormonal therapy (tamoxifen) is recommended for estrogen receptor (er)-positive breast cancer (bca); however, its effect on low-receptor cancers is unclear. We retrospectively evaluated the effect of adjuvant tamoxifen in patients with weakly er-positive bca. METHODS: We identified 2221 bca patients who had been er-tested by ligand-based assay (lba) during 1976-1995 and who had been treated and followed until 2008. Cox proportional hazards models adjusted for age, body mass index, tumour size, nodal status, surgery, and chemotherapy were used to assess the effect of er level on bca survival in patients who received tamoxifen...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490932/contextualizing-the-use-of-oncologic-imaging-within-treatment-phases-imaging-trends-and-modality-preferences-2000-2014
#9
T P Copeland, J M Creasman, D J Seidenwurm, B L Franc
BACKGROUND: In the present study, we retrospectively evaluated the use of tomographic imaging in adult cancer patients to clarify how recent growth plateaus in the use of tomographic imaging in the United States might have affected oncologic imaging during the same period. METHODS: At a U.S. academic cancer centre, 12,059 patients with dates of death from January 2000 through December 2014 were identified. Imaging was restricted to brain and body computed tomography (ct), brain and body magnetic resonance (mr), and body positron-emission tomography (pet) with and without superimposed ct...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490931/treatment-and-outcomes-for-glioblastoma-in-elderly-compared-with-non-elderly-patients-a-population-based-study
#10
E R Morgan, A Norman, K Laing, M D Seal
PURPOSE: Elderly patients make up a large percentage of the individuals newly diagnosed with glioblastoma (gbm), but they face particular challenges in tolerating standard therapy, and compared with younger patients, they experience significantly shorter survival. We set out to compare clinical characteristics, treatment patterns, and outcomes in a non-elderly group (<65 years) and an elderly group (≥65 years) of patients diagnosed with gbm. METHODS: This retrospective population-based study used a province-wide cancer registry to identify patients with a new diagnosis of gbm within a 6-year period (2006-2012)...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490930/metformin-and-breast-cancer-stage-at-diagnosis-a-population-based-study
#11
I C Lega, K Fung, P C Austin, L L Lipscombe
PURPOSE: The objective of the present study was to use a large, population-based cohort to examine the association between metformin and breast cancer stage at diagnosis while accounting for mammography differences. METHODS: We used data from Ontario administrative health databases to identify women 68 years of age or older with diabetes and invasive breast cancer diagnosed from 1 January 2007 to 31 December 2012. Adjusted logistic regression models were used to compare breast cancer stage at diagnosis (stages i and ii vs...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490929/ovarian-cancer-in-manitoba-trends-in-incidence-and-survival-1992-2011
#12
P Lambert, K Galloway, A Altman, M W Nachtigal, D Turner
BACKGROUND: Because the International Cancer Benchmarking Partnership, in a study of diagnosis years between 1995 and 2007, showed lower-than-expected survival for Manitoba's ovarian cancer patients, we undertook an analysis to describe the features of ovarian cancer diagnosed in Manitoba during a 20-year period. We also determined the most recent trends in survival to see if the previous results were sustained. METHODS: In this retrospective cohort study, ovarian cancer cases diagnosed during 1992-2011 were extracted from the Manitoba Cancer Registry...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490928/synthesis-maps-visual-knowledge-translation-for-the-canimpact-clinical-system-and-patient-cancer-journeys
#13
P H Jones, S Shakdher, P Singh
Salient findings and interpretations from the canimpact clinical cancer research study are visually represented in two synthesis maps for the purpose of communicating an integrated presentation of the study to clinical cancer researchers and policymakers. Synthesis maps integrate evidence and expertise into a visual narrative for knowledge translation and communication. A clinical system synthesis map represents the current Canadian primary care and cancer practice systems, proposed as a visual knowledge translation from the mixed-methods canimpact study to inform Canadian clinical research, policy, and practice discourses...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490927/how-different-is-cancer-control-across-canada-comparing-performance-indicators-for-prevention-screening-diagnosis-and-treatment
#14
R Rahal, J Chadder, K DeCaria, G Lockwood, H Bryant
Meaningful performance measures are an important part of the toolkit for health system improvement. The Canadian Partnership Against Cancer has been reporting on pan-Canadian cancer system performance indicators since 2009-work that has led to the availability of standardized measures that can help to shed light on the extent of variation and opportunities for quality improvement across the country. Those measures include a core set of system indicators ranging from prevention and screening, through diagnosis and treatment, to survivorship and end-of-life care...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490926/challenges-and-insights-in-implementing-coordinated-care-between-oncology-and-primary-care-providers-a-canadian-perspective
#15
J R Tomasone, M Vukmirovic, M C Brouwers, E Grunfeld, R Urquhart, M A O'Brien, M Walker, F Webster, M Fitch
We report here on the current state of cancer care coordination in Canada and discuss challenges and insights with respect to the implementation of collaborative models of care. We also make recommendations for future research. This work is based on the findings of the Canadian Team to Improve Community-Based Cancer Care Along the Continuum (canimpact) casebook project. The casebook project identified models of collaborative cancer care by systematically documenting and analyzing Canadian initiatives that aim to improve or enhance care coordination between primary care providers and oncology specialists...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490925/management-of-egfr-mutated-non-small-cell-lung-cancer-practical-implications-from-a-clinical-and-pathology-perspective
#16
REVIEW
M Cabanero, R Sangha, B S Sheffield, M Sukhai, M Pakkal, S Kamel-Reid, A Karsan, D Ionescu, R A Juergens, C Butts, M S Tsao
Starting in the early 2000s, non-small-cell lung cancer (nsclc) subtypes have evolved from being histologically described to molecularly defined. Management of lung adenocarcinomas now generally requires multiple molecular tests at baseline to define the optimal treatment strategy. More recently, second biopsies performed at progression in patients treated with tyrosine kinase inhibitors (tkis) have further defined the continued use of molecularly targeted therapy. In the present article, we focus on one molecular subtype: EGFR-mutated nsclc...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490924/improving-molecular-testing-and-personalized-medicine-in-non-small-cell-lung-cancer-in-ontario
#17
C Lim, H S Sekhon, J C Cutz, D M Hwang, S Kamel-Reid, R F Carter, G da Cunha Santos, T Waddell, M Binnie, M Patel, N Paul, T Chung, A Brade, R El-Maraghi, C Sit, M S Tsao, N B Leighl
BACKGROUND: Although molecular testing has become standard in managing advanced nonsquamous non-small-cell lung cancer (nsclc), most patients undergo minimally invasive procedures, and the diagnostic tumour specimens available for testing are usually limited. A knowledge translation initiative to educate diagnostic specialists about sampling techniques and laboratory processes was undertaken to improve the uptake and application of molecular testing in advanced lung cancer. METHODS: A multidisciplinary panel of physician experts including pathologists, respirologists, interventional thoracic radiologists, thoracic surgeons, medical oncologists, and radiation oncologists developed a specialty-specific education program, adapting international clinical guidelines to the local Ontario context...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490923/multigene-expression-profile-testing-in-breast-cancer-is-there-a-role-for-family-physicians
#18
M A O'Brien, J C Carroll, D P Manca, B Miedema, P A Groome, T Makuwaza, J Easley, N Sopcak, L Jiang, K Decker, M L McBride, R Moineddin, J A Permaul, R Heisey, E A Eisenhauer, M K Krzyzanowska, S Pruthi, C Sawka, N Schneider, J Sussman, R Urquhart, C Versaevel, E Grunfeld
BACKGROUND: Family physicians (fps) play a role in aspects of personalized medicine in cancer, including assessment of increased risk because of family history. Little is known about the potential role of fps in supporting cancer patients who undergo tumour gene expression profile (gep) testing. METHODS: We conducted a mixed-methods study with qualitative and quantitative components. Qualitative data from focus groups and interviews with fps and cancer specialists about the role of fps in breast cancer gep testing were obtained during studies conducted within the pan-Canadian canimpact research program...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490922/a-population-based-assessment-of-primary-care-visits-during-adjuvant-chemotherapy-for-breast-cancer
#19
S J Bastedo, M K Krzyzanowska, R Moineddin, L Yun, K A Enright, E Grunfeld
BACKGROUND: We used administrative health data to explore the impact of primary care physician (pcp) visits on acute-care service utilization by women receiving adjuvant chemotherapy for early-stage breast cancer (ebc). METHODS: Our population-based retrospective cohort study examined pcp visits and acute-care use [defined as an emergency room (er) visit or hospitalization] by women diagnosed with ebc between 2007 and 2009 and treated with adjuvant chemotherapy...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28490921/use-of-physician-services-during-the-survivorship-phase-a-multi-province-study-of-women-diagnosed-with-breast-cancer
#20
C Kendell, K M Decker, P A Groome, M L McBride, L Jiang, M K Krzyzanowska, G Porter, D Turner, R Urquhart, M Winget, E Grunfeld
INTRODUCTION: Oncologists have traditionally been responsible for providing routine follow-up care for cancer survivors; in recent years, however, primary care providers (pcps) are taking a greater role in care during the follow-up period. In the present study, we used a longitudinal multi-province retrospective cohort study to examine how primary care and specialist care intersect in the delivery of breast cancer follow-up care. METHODS: Various databases (registry, clinical, and administrative) were linked in each of four provinces: British Columbia, Manitoba, Ontario, and Nova Scotia...
April 2017: Current Oncology
journal
journal
32168
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"