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Current Oncology

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https://www.readbyqxmd.com/read/28874905/communication-and-informed-consent-a-story
#1
E Aitini
No abstract text is available yet for this article.
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874904/extrahepatic-metastasis-of-hepatocellular-carcinoma-arising-from-a-hepatic-adenoma-without-concurrent-intrahepatic-recurrence
#2
N Poddar, R Ramlal, S Ravulapati, S M Devlin, S Gadani, C I Vidal, D Cao, A S Befeler, J Lai
Hepatocellular carcinoma (hcc) arising from a hepatic adenoma is a rare phenomenon accounting for fewer than 5% of hcc cases; it seldom recurs after resection of the primary tumour. We report a case of extrahepatic metastasis of hcc arising from a hepatic adenoma that presented as a solitary sternal metastasis without any evidence of intrahepatic recurrence. Our patient was initially treated with radiation therapy and bland embolization, without response. Subsequently, the patient developed progressive disease while taking sorafenib...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874903/pomalidomide-desensitization-in-a-patient-hypersensitive-to-immunomodulating-agents
#3
J T Seki, N Sakurai, W Lam, D E Reece
Despite progressive treatments with tandem stem-cell transplantation, patients with incurable myeloma eventually succumb to relapsed or refractory disease if left untreated. Promising agents such as proteasome inhibitors and immunomodulating imide drugs (imids), including the newer-generation agent pomalidomide, in combination with lower-dose dexamethasone, have been shown to be effective and to significantly improve and prolong survival in pretreated patients. Although the incidence of pomalidomide hypersensitivity reaction (hsr) in this class of drugs is not as well known, we have documented cutaneous toxicity (grade 3 by the Common Terminology Criteria for Adverse Events, version 4) in 2 separate cases (not yet published)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874902/lymph-node-retrieval-rates-in-melanoma-a-quality-assessment-parameter
#4
D Berger-Richardson, E Cordeiro, M Ernjakovic, A M Easson
INTRODUCTION: Regional lymph node dissection (rlnd) for melanoma with nodal metastasis is a specialized procedure that is associated with improved disease-specific survival in selected patients. Furthermore, there is evidence that a higher lymph node retrieval rate (lnrr) is associated with improved local control. Currently, no consensus has been reached on the definition of an adequate lnrr. A minimum lnrr has been proposed as a quality assessment parameter that has to be validated. METHODS: We conducted a retrospective cohort analysis at the Princess Margaret Cancer Centre (University Health Network, Toronto, ON)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874901/adrenocortical-carcinoma-patterns-of-care-and-role-of-adjuvant-radiation-therapy-a-population-based-study-and-review-of-the-literature
#5
REVIEW
S Atallah, H Al-Assaf, Y Xu, S El-Sayed
PURPOSE: We reviewed the experience of a tertiary cancer centre in the management of adrenocortical carcinoma (acc) treated over 40 years. We also searched the literature for guidelines related to the treatment of acc and for evidence for adjuvant radiation therapy (rt). METHODS: In a retrospective chart review, acc patients treated between January 1974 and December 2013 were identified, and patient demographics and tumour characteristics were extracted. Outcomes data, including dates and sites of failure, vital status, and cause of death, were collected...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874900/exercise-for-people-with-cancer-a-systematic-review
#6
REVIEW
R Segal, C Zwaal, E Green, J R Tomasone, A Loblaw, T Petrella
BACKGROUND: This systematic review was completed by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario's Program in Evidence-Based Care (pebc). It provides background and guidance for clinicians with respect to exercise for people living with cancer in active and post treatment. It focuses on the benefits of specific types of exercise, pre-screening requirements for new referrals, safety concerns, and delivery models. METHODS: Using the pebc's standardized approach, medline and embase were systematically searched for existing guidelines, systematic reviews, and primary literature...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874899/clinical-results-of-accelerated-hypofractionated-radiotherapy-for-central-type-small-lung-tumours
#7
Y Hatayama, M Aoki, H Kawaguchi, K Hirose, M Sato, H Akimoto, M Tanaka, I Fujioka, K Ichise, S Ono, Y Takai
PURPOSE: We evaluated the efficacy and toxicity of accelerated hypofractionated radiotherapy (ahypof-rt) for central-type small lung tumours. METHODS: Between November 2006 and January 2015, 40 patients with central-type small lung tumours underwent ahypof-rt delivered using 10 MV X-rays and a coplanar 3-field technique. The number of fractions ranged from 24 to 28, with a fraction size of 2.5-3 Gy. A total dose of 69-75 Gy to the isocentre of the planning target volume was administered to each patient...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874898/experiences-of-canadian-oncologists-with-difficult-patient-deaths-and-coping-strategies-used
#8
L Granek, L Barbera, O Nakash, M Cohen, M K Krzyzanowska
OBJECTIVES: We aimed to explore and identify what makes patient death more emotionally difficult for oncologists and how oncologists cope with patient death. METHODS: A convenience sample of 98 Canadian oncologists (50 men, 48 women) completed an online survey that included a demographics section and a section about patient death. RESULTS: More than 80% of oncologists reported that patient age, long-term management of a patient, and unexpected disease outcomes contributed to difficult patient loss...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874897/oral-chinese-herbal-medicine-as-maintenance-treatment-after-chemotherapy-for-advanced-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#9
Q Wang, Q Wang, S F Wang, L J Jiao, R X Zhang, Y Zhong, J Zhang, L Xu
BACKGROUND: The concept of maintenance therapy in cancer treatment is currently under debate because of modest survival benefits, added toxicity, economic considerations, and quality-of-life concerns. Traditional Chinese Medicine (tcm) is widely used in China for cancer patients, offering the advantages of low toxicity and enhancement of quality of life. However, no systematic reviews or meta-analyses have assessed the role of tcm as maintenance treatment for non-small-cell lung carcinoma...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874896/phase-i-ii-trial-of-dose-reduced-capecitabine-in-elderly-patients-with-advanced-colorectal-cancer
#10
M D Vincent, D Breadner, M C Cripps, D J Jonker, P Klimo, J J Biagi, W Lam, A O'Connell, F Whiston, L Stitt, S A Welch
BACKGROUND: Combination chemotherapy is associated with improved outcomes in trials of selected fit patients with advanced colorectal cancer (acrc). For older or less-fit patients, combination chemotherapy is associated with greater toxicity and less benefit. Capecitabine monotherapy is a reasonable option for those patients, but the optimal dose remains controversial. METHODS: A multicentre phase i/ii trial of reduced-dose capecitabine (2000 mg/m(2), days 1-14 every 21 days) was conducted in 221 patients representing one or more of the following subsets: age greater than 65 years (n = 167), Eastern Cooperative Oncology Group (ecog) performance status of 1 or greater (n = 139), elevated lactate dehydrogenase (ldh) (n = 105), or prior pelvic radiation (n = 54)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874895/wherein-the-authors-attempt-to-minimize-the-confusion-generated-by-their-study-breast-cancer-mortality-after-a-diagnosis-of-ductal-carcinoma-in-situ-by-several-commentators-who-disagree-with-them-and-a-few-who-don-t-a-qualitative-study
#11
https://www.readbyqxmd.com/read/28874894/acute-care-hospitalization-near-the-end-of-life-for-cancer-patients-who-die-in-hospital-in-canada
#12
K DeCaria, D Dudgeon, E Green, R Shaw Moxam, R Rahal, J Niu, H Bryant
Acute care hospitals have a role in managing the health care needs of people affected by cancer when they are at the end of life. However, there is a need to provide end-of-life care in other settings, including at home or in hospice, when such settings are more appropriate. Using data from 9 provinces, we examined indicators that describe the current landscape of acute care hospital use at the end of life for patients who died of cancer in hospital in Canada. Interprovincial variation was observed in acute care hospital deaths, length of stay in hospital, readmission to hospital, and intensive care unit use at the end of life...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874893/systemic-therapy-in-incurable-gastroenteropancreatic-neuroendocrine-tumours-a-clinical-practice-guideline
#13
S Singh, D Sivajohanathan, T Asmis, C Cho, N Hammad, C Law, R Wong, K Zbuk
PURPOSE: The purpose of the present review was to determine which antineoplastic systemic therapy is most effective in improving clinical outcomes for patients with incurable gastroenteropancreatic neuroendocrine tumours (nets). METHODS: A systematic search (2008-2016) of the literature in the medline and embase databases and the Cochrane Database of Systematic Reviews was conducted; abstracts from the American Society of Clinical Oncology, the American Society of Clinical Oncology Gastrointestinal Cancers Symposium, the European Society for Medical Oncology, the European Cancer Congress, the European Neuroendocrine Tumor Society, and the North American Neuroendocrine Tumor Society were reviewed...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874892/treatment-patterns-and-trends-in-patients-dying-of-prostate-cancer-in-quebec-a-population-based-study
#14
A Dragomir, J Rocha, M Vanhuyse, F L Cury, W Kassouf, J Hu, A G Aprikian
INTRODUCTION: Since just after the year 2000 in Quebec, the management of metastatic castration-resistant prostate cancer (mcrpc) has evolved considerably, with the inclusion of docetaxel-based chemotherapy, bone-targeted therapies (zoledronic acid and denosumab), and more recently, abiraterone, enzalutamide, and cabazitaxel for docetaxel-refractory patients. In the present study, we aimed to analyze contemporary mcrpc management patterns and therapy utilization trends in Quebec. METHODS: The study cohort consisted of patients dying of prostate cancer (pca) between January 2001 and December 2013, selected from Quebec public health care insurance databases...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874891/real-life-treatment-of-metastatic-colorectal-cancer-with-regorafenib-a-single-centre-review
#15
J Gotfrit, M Vickers, S Sud, T Asmis, C Cripps, R Goel, T Hsu, D Jonker, R Goodwin
BACKGROUND: Various tyrosine kinase signalling pathways affect the development and progression of colorectal cancer (crc). In clinical trials, regorafenib has been associated with a survival benefit in metastatic crc (mcrc). We assessed the safety and efficacy of regorafenib in real-world patients. METHODS: In a retrospective review of patients with mcrc treated with regorafenib at our institution from 2013 to 2015, patient demographics, treatment, and survival data were collected...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874890/patterns-of-spread-and-prognostic-implications-of-lung-cancer-metastasis-in-an-era-of-driver-mutations
#16
F Hsu, A De Caluwe, D Anderson, A Nichol, T Toriumi, C Ho
BACKGROUND: In the present study, we examined the pattern of metastatic spread in patients with advanced non-small-cell lung cancer (nsclc) and the effect of EGFR mutations. METHODS: Patients were identified from a provincial cancer registry, and individual medical records were reviewed. Patients were included if they had stage iv nsclc and underwent diagnostic EGFR mutation testing. Patients were divided into EGFR mutation-positive (EGFR+) and EGFR wild type (wt) cohorts...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874889/user-survey-of-nanny-angel-network-a-free-childcare-service-for-mothers-with-cancer
#17
L Cohen, N Schwartz, A Guth, A Kiss, E Warner
PURPOSE: The purpose of the present study was to determine user satisfaction with Nanny Angel Network (nan), a free childcare service for mothers undergoing cancer treatment. METHODS: All 243 living mothers who had used the nan service were invited by telephone to participate in an online research survey; 197 mothers (81%) consented to participate. The survey, sent by e-mail, consisted of 39 items divided into these categories: demographics, supports, use, satisfaction, and general comments...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874888/women-with-cancer-in-low-income-countries
#18
S A Narod
No abstract text is available yet for this article.
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28874887/when-the-patient-is-also-a-carer
#19
EDITORIAL
E Warner
No abstract text is available yet for this article.
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28680294/carcinoma-ex-pleomorphic-adenoma-case-report-and-options-for-systemic-therapy
#20
N Chooback, Y Shen, M Jones, K Kasaian, M Martin, T Ng, T Thomson, M Marra, J Laskin, C Ho
The most common benign salivary tumour is a pleomorphic adenoma. Transformation to malignancy, carcinoma ex pleomorphic adenoma (cxpa), occurs in 6% of cases. Management focuses on surgical resection and radiotherapy; however, rare cases require systemic management. We present the case of a 60-year-old woman with a cxpa of the left parotid gland who required systemic therapy for locally recurrent disease. Treatment options were guided by the literature concerning malignant salivary gland tumour and by whole-genome and transcriptome sequencing of the tumour...
June 2017: Current Oncology
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