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Journal of Thrombosis and Thrombolysis

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https://www.readbyqxmd.com/read/28643004/effectiveness-and-safety-of-apixaban-therapy-in-daily-care-patients-with-atrial-fibrillation-results-from-the-dresden-noac-registry
#1
Sindy Helmert, Sandra Marten, Heike Mizera, Antje Reitter, Kurtulus Sahin, Luise Tittl, Jan Beyer-Westendorf
The effectiveness and safety of apixaban for stroke prevention in atrial fibrillation (SPAF) demonstrated in ARISTOTLE needs to be confirmed in daily care. To evaluate effectiveness and safety of apixaban therapy in SPAF patients in daily care, we used data from an ongoing, prospective, non-interventional registry of more than 3000 patients on novel oral anticoagulants in daily care. Between 1 December 2012 and 31 August 2015, 514 patients receiving apixaban were enrolled. During a mean follow-up of 803.5 ± 228...
June 22, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28620756/preliminary-data-on-utility-of-subcutaneous-unfractionated-heparin-in-patients-with-deep-cerebral-venous-thrombosis
#2
Girish Baburao Kulkarni, Abbas Masoom Mirza, Subasree Ramakrishnan, Veerendrakumar Mustare
Subcutaneous unfractionated heparin (SCUFH) has been proved effective in puerperal cerebral venous thrombosis (CVT), but its efficacy in the more serious form of the disease such as deep CVT patients (DCVT) unreported. We describe the outcomes of 37 (isolated:combined: 11:26) patients of DCVT diagnosed by MRI, treated with SCUFH in a tertiary care stroke unit. It was a prospective observational cohort study using 5000 U of SCUFH every 6 hourly for 10 days with oral Acenocoumarol started on day 7, with monitoring...
June 15, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28612112/sex-disparities-in-hospitalization-and-mortality-rates-for-venous-thromboembolism
#3
Sola Mansour, Ghazi Alotaibi, Cynthia Wu, Khalid Alsaleh, Michael Sean McMurtry
Venous thromboembolism (VTE) is a major health problem for both men and women. Whether sex disparities exist for outcomes after acute VTE is unknown. We sought to measure sex-specific rates of hospitalization for and mortality from acute VTE. We used a population-based administrative dataset from Alberta, Canada, covering the years 2002 to 2012. We used Poisson regression to measure the incidence rate ratio for hospitalization and Cox regression to test for sex disparities in short-term all-cause mortality after adjusting for potential confounders...
June 13, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28608165/platelet-related-biomarkers-and-their-response-to-inhibition-with-aspirin-and-p2y12-receptor-antagonists-in-patients-with-acute-coronary-syndrome
#4
Angela Lowenstern, Robert F Storey, Megan Neely, Jie-Lena Sun, Dominick J Angiolillo, Christopher P Cannon, Anders Himmelmann, Kurt Huber, Stefan K James, Hugo A Katus, Joao Morais, Agneta Siegbahn, Phillippe Gabriel Steg, Lars Wallentin, Richard C Becker
The PLATelet inhibition and patient Outcomes (PLATO) trial showed that treatment with ticagrelor reduced the rate of death due to vascular causes, myocardial infarction and stroke when compared to clopidogrel in patients with ST-elevation or non-ST-elevation acute coronary syndrome (ACS). While the comparative benefit of ticagrelor over clopidogrel increased over time, event rates accrued in both groups during the study period. The purpose of our biomarker-based exploratory analysis was to determine whether long-term platelet inhibition may be associated with platelet adaptation...
June 12, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28600623/fibrin-specific-and-effective-clot-lysis-requires-both-plasminogen-activators-and-for-them-to-be-in-a-sequential-rather-than-simultaneous-combination
#5
R Pannell, S Li, V Gurewich
Thrombolysis with tissue plasminogen activator (tPA) has been a disappointment and has now been replaced by an endovascular procedure whenever possible. Nevertheless, thrombolysis remains the only means by which circulation in a thrombosed artery can be restored rapidly. In contrast to tPA monotherapy, endogenous fibrinolysis uses both tPA and urokinase plasminogen activator (uPA), whose native form is a proenzyme, prouPA. This combination is remarkably effective as evidenced by the fibrin degradation product, D-dimer, which is invariably present in plasma...
June 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28597206/effect-of-strut-distribution-on-neointimal-coverage-of-everolimus-eluting-bioresorbable-scaffolds-an-optical-coherence-tomography-study
#6
Takao Sato, John Jose, Abdelhakim Allai, Mohamed El-Mawardy, Ralph Tölg, Gert Richardt, Mohamed Abdel-Wahab
The thick struts of bioresorbable vascular scaffolds (BRS) are associated with changes in wall shear stress and contribute to neointimal proliferation. We aimed to evaluate the relationship between the BRS strut distribution and the neointimal proliferation. 50 lesions underwent optical coherence tomography, 12 months after BRS implantation. Scaffold area and neointimal thickness were evaluated in each cross-sectional area (CSA). Scaffold eccentricity was defined as follows: (maximum diameter - minimum diameter) × 100/maximum diameter...
June 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28589302/implementation-of-an-institutional-protocol-to-improve-inferior-vena-cava-utilization-and-outcomes
#7
Amihai Rottenstreich, Ariela Arad, Naama Lev Cohain, Allan I Bloom, David Varon, Alexander Klimov, Batia Roth, Yosef Kalish
To evaluate the impact of an institutional protocol on patterns of use and outcomes of inferior vena cava filters (IVCF). Following a multidisciplinary effort, an institutional protocol involving dedicated follow-up of patients receiving IVCF and a physician education program regarding IVCF utilization, was established. We prospectively collected data of patients who received IVCF during 2015-2016, following protocol implementation (POST group). For comparison, we reviewed records of patients who received IVCF during 2009-2014, before implementation of the institutional protocol (PRE group)...
June 6, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28580515/dabigatran-reduces-thrombin-induced-platelet-aggregation-and-activation-in-a-dose-dependent-manner
#8
Pernille Just Vinholt, Christian Nielsen, Anna Cecilia Söderström, Axel Brandes, Mads Nybo
Dabigatran is an oral anticoagulant and a reversible inhibitor of thrombin. Further, dabigatran might affect platelet function through a direct effect on platelet thrombin receptors. The aim was to investigate the effect of dabigatran on platelet activation and platelet aggregation. Healthy donor blood was incubated with dabigatran 0, 50, 500 ng/mL, corresponding to the therapeutic range of dabigatran peak plasma concentrations, and 10,000 ng/mL comprising a supra-therapeutic dabigatran plasma level. Platelet aggregation was tested with 96-well aggregometry...
June 3, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28577159/biventricular-thrombosis-in-biventricular-stress-takotsubo-cardiomyopathy
#9
Luisa De Gennaro, Massimo Ruggiero, Sergio Musci, Francesco Tota, Domenica De Laura, Manuela Resta, Nicola Locuratolo, Francesco Santoro, Natale Daniele Brunetti, Pasquale Caldarola
Endo-ventricular thrombosis represents a possible clinical complication of stress(takotsubo)-cardiomyopathy (SC). Depressed ventricular systolic ventricular function, localized left ventricular (LV) dyskinesis, but also an increased pro-thrombotic state induced by catecholamine surge may facilitate the occurrence of endovascular thrombosis in SC. SC, however, may also present as right ventricular (RV) dysfunction or even as biventricular ballooning. Ventricular thrombosis may therefore theoretically occur in either ventricles or both...
June 2, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28569368/comparison-of-body-mass-index-waist-circumference-and-waist-height-ratio-in-predicting-functional-outcome-following-ischemic-stroke
#10
Kyusik Kang, Wong-Woo Lee, Jung-Ju Lee, Jong-Moo Park, Ohyun Kwon, Byung Kun Kim
Although a positive association between body mass index (BMI) and stroke incidence has been reported, having a higher BMI is known to be advantageous in surviving and recovering from stroke. The association between adiposity and stroke incidence is more evident for measures of abdominal obesity than for general obesity. The aim of our study was to compare BMI, waist circumference, and waist-height ratio (WHR) as predictors of 3-month functional outcome in stroke patients. The BMI, waist circumference, and WHR of acute stroke patients were divided into sex-specific quartiles...
May 31, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28550629/retrospective-analysis-of-outcomes-following-inferior-vena-cava-ivc-filter-placement-in-a-managed-care-population
#11
Damian Everhart, Jamieson Vaccaro, Karen Worley, Teresa L Rogstad, Mitchel Seleznick
The role of inferior vena cava filter (IVC) filters for prevention of pulmonary embolism (PE) is controversial. This study evaluated outcomes of IVC filter placement in a managed care population. This retrospective cohort study evaluated data for individuals with Humana healthcare coverage 2013-2014. The study population included 435 recipients of prophylactic IVC filters, 4376 recipients of therapeutic filters, and two control groups, each matched to filter recipients. Patients were followed for up to 2 years...
May 26, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28540468/benefits-and-harms-of-4-factor-prothrombin-complex-concentrate-for-reversal-of-vitamin-k-antagonist-associated-bleeding-a-systematic-review-and-meta-analysis
#12
REVIEW
Marjolein P A Brekelmans, Kim van Ginkel, Joost G Daams, Barbara A Hutten, Saskia Middeldorp, Michiel Coppens
Prothrombin complex concentrate (PCC) is used for reversal of vitamin K antagonists (VKA) in patients with bleeding complications. This study aims to assess benefits and harms of 4-factor PCC compared to fresh frozen plasma (FFP) or no treatment in VKA associated bleeding. PubMed, EMBASE and CENTRAL were searched from 1945 to August 2015. Studies reporting 4-factor PCC use for VKA associated bleeding and providing data on INR normalization, mortality or thromboembolic (TE) complications were eligible. Two authors screened titles and full articles for inclusion, extracted data, and assessed risk of bias...
May 24, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28534102/circulating-microaggregates-during-cardiac-surgery-precedes-postoperative-stroke
#13
Zühre Uz, Dan M J Milstein, Can Ince, Bastian A J M de Mol
Postoperative stroke and encephalopathy are potentially serious complications associated with coronary artery bypass grafting. In this case report a 78-year-old male patient receiving routine elective cardiac surgery presented with microaggregations in the sublingual microcirculation while on cardiopulmonary bypass that was undetected by routine intraoperative anticoagulation assessment. Microaggregates identified using video microscopy on his sublingual microcirculation during the procedure preceded a stroke postoperatively...
May 22, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28497223/successful-endovascular-treatment-of-popliteal-artery-entrapment-syndrome-a-case-report-with-3-years-follow-up
#14
Xiaodong Wang, Hongkun Zhang, Jin Yan, Ziying Lu
Popliteal artery entrapment syndrome (PAES) is a rare cause of lower extremity arterial ischemia, especially in elder patients. At present, the role of the endovascular technique for PAES is still mainly auxiliary, there is no successful case treated successfully by endovascular treatment without open surgery, and also the long-term follow-up after endovascular treatment are lacking. We successfully treated a 51-year-old man with pale, cold right foot by endovascular therapy only, including percutaneous transluminal angioplasty and catheter directed thrombolysis...
May 11, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28488237/perioperative-bleeding-and-thrombotic-risks-in-patients-with-von-willebrand-disease
#15
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Sripal Bangalore, Jeffrey S Berger
Von Willebrand disease (VWD) is an inherited bleeding disorder that often manifests clinically with hemorrhage after invasive procedures. We investigated the association between a diagnosis of VWD and bleeding and thrombotic outcomes following major non-cardiac surgery in a large national database from the United States. Patients age ≥45 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data. Von Willebrand disease, perioperative major adverse cardiovascular events (MACE), thrombotic events, and hemorrhage were defined by ICD9 diagnosis codes...
May 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28488236/dabigatran-plasma-levels-aptt-and-thromboelastography-in-patients-with-af-implications-for-allowing-early-non-elective-surgical-procedures
#16
Athanasios Pipilis, Stamatis Makrygiannis, Georgios Anagnostou, Sotirios Kaliampakos, Georgios Tsakonas, Nikolaos Sourlas, Panagiotis Mallios, Theodora Kostelidou
According to current recommendations, patients on dabigatran should stop the drug 24-96 h before scheduled surgery. This may seem too long for non-elective cases. The aim of our study was to assess the number of patients on dabigatran who could theoretically undergo surgery 12 h post last drug dosing. We measured dabigatran plasma trough concentration by Hemoclot assay in 75 consecutive patients receiving dabigatran. Coagulation was assessed by aPTT and thromboelastography (TEG). Plasma levels ≤30 ng/ml were considered low...
May 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28484939/a-systematic-review-of-mobility-immobility-in-thromboembolism-risk-assessment-models-for-hospitalized-patients
#17
REVIEW
Fan Ye, Carolyn Stalvey, Matheen A Khuddus, David E Winchester, Hale Z Toklu, Joseph J Mazza, Steven H Yale
Hospitalized patients are at risk of venous thromboembolism (VTE) and prophylaxis is often suboptimal due to difficulty in identifying at-risk patients. Simple and validated risk-assessment models (RAMs) are available to assist clinicians in identifying patients who have a high risk for developing VTE. Despite the well-documented association of immobility with increased risk of thrombosis, immobility is not consistently defined in clinical studies. We conducted a systematic review of published VTE RAMs and used objective criteria to determine how the term immobility is defined in RAMs...
May 8, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28447244/retinal-vein-occlusion-and-paroxysmal-nocturnal-hemoglobinuria
#18
LETTER
Marc Sorigue, Jordi Juncà, Elisa Orna, Nevena Romanic, Edurne Sarrate, Jordi Castellvi, Montse Soler, Ines Rodríguez-Hernandez, Evarist Feliu, Susana Ruiz
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened for the presence of a PNH clone in peripheral blood by means of flow cytometry. The presence of other well-documented risk factors for RVO was also analyzed. In a series of 110 patients (54 males, median age of 67) we found no evidence of PNH...
April 26, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28429248/time-in-therapeutic-range-as-a-marker-for-thrombotic-and-bleeding-outcomes-in-fontan-patients
#19
Jenna M Faircloth, Kristin M Miner, Tarek Alsaied, Nicole Nelson, Julie Ciambarella, Tomoyuki Mizuno, Joseph S Palumbo, Alexander A Vinks, Gruschen R Veldtman
Fontan patients managed with warfarin are at risk not only for thrombotic events, but also for bleeding episodes as a consequence of anticoagulation treatment. The aim of this study was to determine whether time spent in patient specified therapeutic range (TTR), when managed in a cardiology-based pharmacist managed anticoagulation clinic (PMAC), is a useful target metric for monitoring, as well as improving outcomes. A single center retrospective review was conducted evaluating TTR of all Fontan patients (n = 45) on warfarin managed in our outpatient cardiology pharmacist managed anticoagulation clinic (PMAC) during a 19 month time frame...
April 20, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28425010/a-novel-fibrinogen-variant-dysfibrinogenemia-associated-with-%C3%AE-asp185asn-substitution
#20
Na Zhou, Peipei Xu, Min Zhou, Yong Xu, Ping Li, Bin Chen, Jian Ouyang, Rongfu Zhou
To identify the pathogenesis of a Chinese woman diagnosed with dysfibrinogenemia. A patient from Nanjing presented with a low plasma concentration of fibrinogen and a normal level of antigen of fibrinogen. This abnormality was also detected in her son. To detect whether the genetic mutation was responsible for the dysfibrinogenemia, genomic DNA was extracted and amplified by polymerase chain reaction, and DNA sequencing was performed on the purified PCR products. Restriction fragment length polymorphism (RFLP), molecular modeling and homologous sequences alignment were performed...
April 19, 2017: Journal of Thrombosis and Thrombolysis
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