journal
MENU ▼
Read by QxMD icon Read
search

Journal of Thrombosis and Thrombolysis

journal
https://www.readbyqxmd.com/read/28921408/catheter-ablation-for-af-improves-global-thrombotic-profile-and-enhances-fibrinolysis
#1
Maria Niespialowska-Steuden, Vias Markides, Mohamed Farag, David Jones, Wajid Hussain, Tom Wong, Diana A Gorog
Patients with atrial fibrillation (AF) are at increased risk of thrombotic events despite oral anticoagulation (OAC). Radiofrequency catheter ablation (RFCA) can restore and maintain sinus rhythm (SR) in patients with AF. To assess whether RFCA improves thrombotic status. 80 patients (71% male, 64 ± 12y) with recently diagnosed AF, on OAC and scheduled to undergo RFCA or DC cardioversion (DCCV) were recruited. Thrombotic status was assessed using the point-of-care global thrombosis test (GTT), before, and 4-6 weeks after DCCV and 3 months after RFCA...
September 18, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28918569/highlights-from-the-ninth-international-symposium-of-thrombosis-and-anticoagulation-ista-ix-october-15-2016-salvador-bahia-brazil
#2
REVIEW
Renato D Lopes, Patricia O Guimarães, Elaine Hylek, Gilson S Feitosa-Filho, Luiz Ritt, Nivaldo Filgueiras, Eduardo Darzé, Mario S Rocha, Luis P Magalhães, Antonio Carlos Sobral Sousa, Luis Claudio Correia, Lucas Hollanda Oliveira, David A Garcia
To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Ninth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, on October 15, 2016. This scientific program was developed by clinicians for clinicians and was promoted by two major clinical research institutes-the Brazilian Clinical Research Institute and the Duke Clinical Research Institute of the Duke University School of Medicine. Comprising academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists...
September 16, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28918448/a-systematic-review-of-cost-effectiveness-analysis-of-screening-interventions-for-assessing-the-risk-of-venous-thromboembolism-in-women-considering-combined-oral-contraceptives
#3
REVIEW
Zanfina Ademi, C Simone Sutherland, Joris Van Stiphout, Jöelle Michaud, Goranka Tanackovic, Matthias Schwenkglenks
Use of combined oral contraceptives (COCs) by women increases the risk of venous thromboembolism (VTE), which can have a major impact on an individuals' quality of life. VTE is also associated with an increase in healthcare costs. Our aim was to systematically review cost-effectiveness analyses (CEAs) considering any screening for risk of VTE in women using COCs. The quality of reporting in each study was assessed, a summary of results was prepared, and the key drivers of cost effectiveness in each of the eligible CEAs were identified...
September 16, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28914415/a-randomized-trial-of-restarting-warfarin-at-maintenance-versus-loading-doses-following-an-elective-procedure
#4
Tammy J Bungard, Jay Mutch, Bruce Ritchie
Guidelines suggest restarting warfarin at known maintenance doses, although this may result in a delay to achieving therapeutic anticoagulation. As such, we compared the time to achieve an INR ≥ 2.0 between those restarting warfarin maintenance vs loading doses after transient interruption, and the impact on protein C, S and factor II levels. Patients requiring interruption of warfarin for elective procedures without hospitalization were randomized 1:1 to receive warfarin maintenance or loading doses (1...
September 15, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28913672/reversal-of-dabigatran-associated-bleeding-using-idarucizumab-review-of-the-current-evidence
#5
REVIEW
Michela Giustozzi, Melina Verso, Giancarlo Agnelli, Cecilia Becattini
Major bleeding occurs in about 4% of patients while on treatment with direct oral anticoagulants (DOACs). The case-fatality rate associated with these events is estimated to be about 5%. The specific roles of antidotes, when used with DOACs in reducing the case fatality or improving the overall clinical course of these events, are not thoroughly understood. To this regard, the US Food and Drug Administration as well as European Medicines Agency have recently licensed idarucizumab for the management of patients with life-threatening bleeding or the need for urgent surgery/procedures while on treatment with dabigatran...
September 14, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28905178/single-versus-dual-anti-platelet-therapy-post-transcatheter-aortic-valve-implantation-a-meta-analysis-of-randomized-controlled-trials
#6
Tomo Ando, Hisato Takagi, Alexandros Briasoulis, Luis Afonso
The purpose of this systematic review and meta-analysis was to assess the 30-days safety (bleeding and vascular events) and efficacy (reduction in major stroke, myocardial infarction and mortality) of single anti-platelet (SAPT) versus dual anti-platelet (DAPT) after transcatheter aortic valve implantation (TAVI). We used a meta-analytic method with Mantel-Haenszel methods to calculate the odds ratio (OR) and 95% confidence interval (CI). Only randomized clinical trials that compared 30-days safety and efficacy based on Valve Academic Research Consortium criteria were included...
September 13, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28905172/n-terminal-pro-b-type-natriuretic-peptide-and-the-risk-of-stroke-among-patients-hospitalized-with-acute-heart-failure-an-apex-trial-substudy
#7
Gerald Chi, James L Januzzi, Serge Korjian, Yazan Daaboul, Samuel Z Goldhaber, Adrian F Hernandez, Russell D Hull, Alex Gold, Alexander T Cohen, Robert A Harrington, C Michael Gibson
BACKGROUND: Among patients hospitalized with acute heart failure (HF), the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in short-term stroke prediction remains unclear. METHODS: In the APEX trial, 7513 patients hospitalized for an acute medical illness were randomized to receive either extended-duration betrixaban (80 mg once daily for 35-42 days) or standard-of-care enoxaparin (40 mg once daily for 10 ± 4 days) for venous thromboprophylaxis...
September 13, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28889321/effects-of-purified-human-fibrinogen-modified-with-carbon-monoxide-and-iron-on-coagulation-in-rabbits-injected-with-crotalus-atrox-venom
#8
Vance G Nielsen
While snake venom derived enzymes, such as the thrombin-like activity possessing ancrod, have been used to treat thrombotic disease by defibrinogenating patients, the therapeutic potential of fibrinogenolytic snake venom enzymes, such as those derived from Crotalus atrox, have not been fully explored. However, one of the potential risks of administering fibrinogenolytic enzymes to effect defibrinogenation is hemorrhage secondary to hypofibrinogenemia. The present investigation sought to determine if human fibrinogen modified with carbon monoxide (CO) and iron (Fe) could resist degradation by C...
September 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28889200/prevalence-of-common-hereditary-risk-factors-for-thrombophilia-in-somalia-and-identification-of-a-novel-gln544arg-mutation-in-coagulation-factor-v
#9
Abshir Ali Abdi, Abdimajid Osman
Thrombophilia, commonly manifested as venous thromboembolism (VTE), is a worldwide concern but little is known on its genetic epidemiology in many parts of the globe particularly in the developing countries. Here we employed TaqMan genotyping and pyrosequencing to evaluate the prevalence of known common nucleotide polymorphisms associated with thrombophilia in a Somali population in the Puntland region of Somalia. We also employed next generation sequencing (NGS) to investigate other genetic variants in a Somali patient with deep venous thrombosis (DVT)...
September 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28884390/patients-treated-for-acute-vte-during-periods-of-treatment-related-thrombocytopenia-have-high-rates-of-recurrent-thrombosis-and-transfusion-related-adverse-outcomes
#10
B T Samuelson Bannow, R B Walter, T B Gernsheimer, D A Garcia
Venous thromboembolism (VTE) is a common complication of hematologic malignancies. Prolonged periods of thrombocytopenia are experienced universally by patients undergoing treatment for these diseases, yet data to guide management of anticoagulation in this setting are lacking. To obtain data on the management and outcomes of VTE in patients with thrombocytopenia related to the treatment of hematologic malignancies. This was an observational cohort study of patients experiencing VTE during periods of treatment-related thrombocytopenia over a 5-year period at the Fred Hutchinson Cancer Research Center...
September 7, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28879581/activation-of-blood-coagulation-and-thrombin-generation-in-acute-ischemic-stroke-treated-with-rtpa
#11
Sarah Goldman, Shannon M Prior, Jan P Bembenek, Maciej Niewada, Elżbieta Broniatowska, Anna Członkowska, Saulius Butenas, Anetta Undas
The impact of thrombolysis with recombinant tissue plasminogen activator (rtPA) on blood coagulation in acute ischemic stroke (AIS) patients is not completely understood. We studied the effect of thrombolysis on the thrombin generation (TG) profile as well as coagulant activity of activated factors IX (FIXa), XI (FXIa) and tissue factor (TF) in AIS patients. In a case-control study, TG parameters as well as FIXa, FXIa and TF levels were assessed in 95 AIS patients, including individuals receiving rtPA treatment within 4...
September 6, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28875371/the-effective-systematic-heparin-pre-treatment-on-thrombus-formation-on-pulmonary-artery-catheter-tips-during-pulmonary-endarterectomy-for-chronic-thromboembolic-pulmonary-hypertension-a-randomized-double-blind-study
#12
Christoph B Wiedenroth, Christoph Liebetrau, Henning Gall, Thomas Risch, Matthias Arlt, Eckhard Mayer, Stefan Guth
Pulmonary artery (PA) catheters are routinely used for hemodynamic management in patients with chronic thromboembolic pulmonary hypertension (CTEPH) undergoing pulmonary endarterectomy (PEA). Tip-associated thrombi are frequently detected and might increase the peri-operative risk in these patients. The aim of the study was to investigate the effects of low-dose heparinization before the insertion of the PA catheter on thrombus formation and thrombus weight during PEA surgery. From September 2013 to February 2015, 60 CTEPH patients undergoing PEA were included in the study and randomized into two groups of 30 patients each, including a heparin group (heparin bolus (70 IU per kg body weight) administration before PA catheter insertion) and a control group (pretreatment with placebo)...
September 5, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28866770/anti-coagulant-activity-of-plants-mini-review
#13
REVIEW
Muhammad Akram, Abid Rashid
Medicinal plants have been used for treatment of human ailments since ancient times. Objective of this study is to document the effect of herbal drugs on anticoagulant therapy. The material for this review was taken mostly from PubMed and the Cochrane database of systematic reviews. Some other relevant references were collected from personal database of papers on anti-coagulant properties of plants. Literature review shows that many plants such as Thymus vulgaris, Cyamopsis tetragonoloba taub, Pulmonaria officinalis and Cinnamomum cassia etc have anti-coagulant activity...
September 2, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28864991/evaluating-safety-of-thrombolysis-in-chronic-kidney-disease-patients-presenting-with-pulmonary-embolism-using-propensity-score-matching
#14
Brijesh Patel, Naveen Sablani, Mahek Shah, Lohit Garg, Manyoo Agarwal, Sahil Agrawal, Susan Steigerwalt, Raman Dusaj
To assess the safety of thrombolytic therapy in chronic kidney disease (CKD) patients who present with pulmonary embolism (PE). We used the Nationwide Inpatient Sample Database to identify patients who underwent thrombolysis for PE between 2010 and 2014. The patients were divided into two groups: (1) No CKD and (2) CKD. Patients with and without CKD were matched using 1:1 propensity score matching and a caliper width of 0.01. The primary outcomes were in-hospital mortality and hemorrhagic events. The secondary outcomes were blood transfusions, length of stay and total hospitalization charge...
September 1, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28861769/erratum-to-obstetric-antiphospholipid-syndrome-and-long-term-arterial-thrombosis-risk
#15
Genady Drozdinsky, Eran Hadar, Anat Shmueli, Rinat Gabbay-Benziv, Shachaf Shiber
No abstract text is available yet for this article.
August 31, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28861758/venous-thromboembolism-prophylaxis-for-ambulatory-cancer-patients-can-we-do-better
#16
REVIEW
Hikmat Abdel-Razeq, Asem Mansour
Patients with cancer are at a much higher risk of thromboembolic events. Such events are occasionally associated with significant complications that can negatively affect patients' quality of life. Thromboprophylaxis is widely practiced, but much of the emphasis is given for those admitted with acute medical illnesses or following major surgical procedures. However, a significant percentage of thrombotic events encountered in routine clinical practice are among ambulatory patients where current guidelines do not recommend routine thromboprophylaxis...
August 31, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28852931/comorbidity-assessment-as-predictor-of-short-and-long-term-mortality-in-elderly-patients-with-hemodynamically-stable-acute-pulmonary-embolism
#17
Hernan Polo Friz, Valeria Corno, Annalisa Orenti, Chiara Buzzini, Chiara Crivellari, Francesco Petri, Melisa Polo Friz, Veronica Punzi, Daniela Teruzzi, Luca Cavalieri d'Oro, Cristina Giannattasio, Giuseppe Vighi, Claudio Cimminiello, Patrizia Boracchi
Elderly patients presenting with acute pulmonary embolism (PE) frequently have significant underlying comorbidities which may condition the prognosis. The current study aimed to determine the ability of Charlson comorbidity index (CCI) score to predict short and long-term mortality in elderly patients with hemodynamically stable acute PE. All hemodynamically stable patients aged >65 years with acute PE, evaluated in the Emergency Department since 2010 through 2014, were included in this retrospective cohort study...
August 29, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28840456/effects-of-statin-therapy-on-platelet-reactivity-after-percutaneous-coronary-revascularization-in-patients-with-acute-coronary-syndrome
#18
Anna Toso, Stefano De Servi, Mario Leoncini, Dominick J Angiolillo, Paolo Calabrò, Federico Piscione, Marco Cattaneo, Diego Maffeo, Antonio Bartorelli, Cataldo Palmieri, Marco De Carlo, Davide Capodanno, Philippe Genereux, Francesco Bellandi, Chiara Barozzi, Luciana Tomasi, Diego Della Riva, Tullio Palmerini
Statin use is associated with enhanced pharmacodynamic response to clopidogrel in patients with stable coronary artery disease undergoing percutaneous coronary intervention (PCI). However, the impact of statin therapy on clopidogrel response profiles in patients with acute coronary syndrome (ACS) undergoing PCI has not been established and represents the objective of this investigation. On-treatment P2Y12 platelet reactivity was measured using the vasodilator stimulated phosphoprotein (VASP) phosphorylation assay before PCI, at hospital discharge, and at 1 month after PCI in ACS patients enrolled in the multicenter, prospective GEne polymorphisms, Platelet Reactivity, and Syntax Score (GEPRESS) study (n = 962)...
August 24, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28836150/anticoagulation-for-the-treatment-of-venous-thromboembolism-in-patients-with-brain-metastases-a-meta-analysis-and-systematic-review
#19
Bradley D Hunter, Tracy Minichiello, Stephen Bent
The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on survival in patients with brain metastases and venous thromboembolism (VTE). A systematic review of the literature was performed via the PubMed, EMBASE, and the Cochrane databases. Our initial search resulted in 1304 unique citations, and 5 studies satisfied all eligibility criteria and were included for analysis...
August 23, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28828713/efficacy-of-standard-dose-unfractionated-heparin-for-venous-thromboembolism-prophylaxis-in-morbidly-obese-and-non-morbidly-obese-critically-ill-patients
#20
Young R Lee, Delilah D Blanco
To determine the efficacy of standard dose unfractionated heparin (UFH) for venous thromboembolism (VTE) prophylaxis in critically ill morbidly obese patients. Retrospective single-center observational cohort study in a single tertiary teaching hospital intensive care units (ICUs) in Multiparameter Intelligent Monitoring in Intensive Care II Clinical Database. Patients 18 years or older, admitted to the ICU, and received either UFH 5000 units subcutaneously twice daily or UFH 5000 units three times daily for VTE prophylaxis between 2001 and 2008 were included...
August 21, 2017: Journal of Thrombosis and Thrombolysis
journal
journal
32163
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"