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Journal of Thrombosis and Thrombolysis

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https://www.readbyqxmd.com/read/27900627/extended-duration-versus-short-duration-pharmacological-thromboprophylaxis-in-acutely-ill-hospitalized-medical-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Aaron Y L Liew, Siavash Piran, John W Eikelboom, James D Douketis
Extended-duration pharmacological thromboprophylaxis, for at least 28 days, is effective for the prevention of symptomatic venous thromboembolism (VTE) in high-risk surgical patients but is of uncertain benefit in hospitalized medical patients. We aimed to evaluate the efficacy and safety of extended-duration thromboprophylaxis in hospitalized medical patients. We conducted a systematic PubMed, Medline and EMBASE literature search until June 2016 and a meta-analysis of randomized controlled trials which compared extended-duration with short-duration thromboprophylaxis in hospitalized medical patients...
November 30, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27896543/vitamin-k-antagonists-relative-strengths-and-weaknesses-vs-direct-oral-anticoagulants-for-stroke-prevention-in-patients-with-atrial-fibrillation
#2
REVIEW
Andreas Zirlik, Christoph Bode
Vitamin K antagonists (VKAs) have been the mainstay of anticoagulation therapy for more than 50 years. VKAs are mainly used for the prevention of stroke in patients with atrial fibrillation (AF) and the treatment and secondary prevention of venous thromboembolism. In the past 5 years, four new agents-the direct factor Xa inhibitors apixaban, edoxaban and rivaroxaban and the direct thrombin inhibitor dabigatran [collectively known as direct oral anticoagulants (DOACs) or non-VKA oral anticoagulants]-have been approved for these and other indications...
November 28, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27878507/the-scope-and-value-of-an-anticoagulation-stewardship-program-at-a-community-teaching-hospital
#3
Maura K Wychowski, Christina I Ruscio, Peter A Kouides, Ronald L Sham
To report the impact of an inpatient anticoagulation stewardship program at a community hospital to promote optimal anticoagulant use. The anticoagulation team (ACT) stewardship program consists of two clinical pharmacists and hematologists to provide oversight of anticoagulants, high cost reversal agents including prothrombin complex concentrate (PCC, Kcentra™), and heparin-induced thrombocytopenia (HIT) management. Intervention data and number of charts reviewed were collected. Average cost avoidance data was applied to ACT interventions to estimate cost savings...
November 22, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27864647/prethrombotic-prothrombotic-thrombophilic-states-hypercoagulable-state-thrombophilia-etc-semantics-should-be-respected-even-in-medical-papers
#4
REVIEW
A Girolami, E Cosi, S Ferrari, A M Lombardi, B Girolami
The study of prothrombotic or thrombophilic states have drawn considerable attention during the past two decades. This was the result of the increasing number of thrombotic events, both arterial and venous reported all over the world but especially in the developed countries. This wealth of studies and papers have not always respected the semantical significance of the various terms used, namely prethrombotic state, hypercoagulable state, thrombophilic or prothrombotic state, thrombophilia, susceptibility to thrombosis and procoagulant state...
November 18, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27848065/impact-of-valvular-heart-disease-on-oral-anticoagulant-therapy-in-non-valvular-atrial-fibrillation-results-from-the-ramses-study
#5
Özcan Başaran, Volkan Dogan, Osman Beton, Mehmet Tekinalp, Ahmet Çağrı Aykan, Ezgi Kalaycıoğlu, Ismail Bolat, Onur Taşar, Özgen Şafak, Macit Kalçık, Mehmet Yaman, Sinan İnci, Bernas Altıntaş, Sedat Kalkan, Cevat Kırma, Murat Biteker
The definition of non-valvular atrial fibrillation (NVAF) is controversial. We aimed to assess the impact of valvular heart disease on stroke prevention strategies in NVAF patients. The RAMSES study was a multicenter and cross-sectional study conducted on NVAF patients (ClinicalTrials.gov identifier NCT02344901). The study population was divided into patients with significant valvular disease (SVD) and non-significant valvular disease (NSVD), whether they had at least one moderate valvular disease or not. Patients with a mechanical prosthetic valve and mitral stenosis were excluded...
November 15, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27844303/acute-apixaban-treatment-of-heparin-induced-thrombocytopenia
#6
LETTER
Guillermo Delgado-García, Roberto Monreal-Robles
No abstract text is available yet for this article.
November 14, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27844302/protein-z-and-atherosclerotic-disease-a-less-close-relationship-than-though
#7
LETTER
José Pardos-Gea
No abstract text is available yet for this article.
November 14, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27838806/early-function-decline-after-ischemic-stroke-can-be-predicted-by-a-nomogram-based-on-age-use-of-thrombolysis-rdw-and-nihss-score-at-admission
#8
Gianni Turcato, Gianfranco Cervellin, Manuel Cappellari, Antonio Bonora, Massimo Zannoni, Paolo Bovi, Giorgio Ricci, Giuseppe Lippi
The availability of prediction tools for risk stratification after acute stroke is seen as a valuable perspective for tailored clinical management. This retrospective study was aimed to identify significant predictors of poor outcome in patients presenting with acute ischemic stroke, which could then be used for constructing a prediction model. The study population consisted of 837 patients admitted to the Stoke Unit of University Hospital of Verona (Italy) for acute ischemic stroke within 12 h of symptoms onset...
November 12, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27837310/st-elevation-no-myocardial-infarction
#9
LETTER
Peter Damman, Robbert J de Winter, Mitchell W Krucoff
No abstract text is available yet for this article.
November 11, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27837309/prescribing-trends-of-atrial-fibrillation-patients-who-switched-from-warfarin-to-a-direct-oral-anticoagulant
#10
Zachary D Hale, Xiowen Kong, Brian Haymart, Xiaokui Gu, Eva Kline-Rogers, Steve Almany, Jay Kozlowski, Gregory D Krol, Scott Kaatz, James B Froehlich, Geoffrey D Barnes
Direct oral anticoagulant (DOAC) agents offer several lifestyle and therapeutic advantages for patients relative to warfarin in the treatment of atrial fibrillation (AF). These alternative agents are increasingly used in the treatment of AF, however the adoption practices, patient profiles, and reasons for switching to a DOAC from warfarin have not been well studied. Through the Michigan Anticoagulation Quality Improvement Initiative, abstracted data from 3873 AF patients, enrolled between 2010 and 2015, were collected on demographics and comorbid conditions, stroke and bleeding risk scores, and reasons for anticoagulant switching...
November 11, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27822906/simultaneous-large-bi-atrial-device-related-thrombi
#11
Jonas Dominik Häner, Christian Seiler
Simultaneous appearance of a pacemaker-lead associated thrombus and a left atrial appendage closure device related thrombus in a patient with urothelial carcinoma shown in a transesophageal echocardiography.
November 7, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27822905/associations-between-homocysteine-metabolism-related-snps-and-carotid-intima-media-thickness-a-chinese-sib-pair-study
#12
Kexin Sun, Jing Song, Kuo Liu, Kai Fang, Ling Wang, Xueyin Wang, Jing Li, Xun Tang, Yiqun Wu, Xueying Qin, Tao Wu, Pei Gao, Dafang Chen, Yonghua Hu
Carotid intima-media thickness (CIMT) is a good surrogate for atherosclerosis. Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aim to investigate the relationships between homocysteine (Hcy) related biochemical indexes and CIMT, the associations between Hcy related SNPs and CIMT, as well as the potential gene-gene interactions. The present study recruited full siblings (186 eligible families with 424 individuals) with no history of cardiovascular events from a rural area of Beijing...
November 7, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27822904/a-new-prognostic-strategy-for-adult-patients-with-acute-pulmonary-embolism-eligible-for-outpatient-therapy
#13
Federico Angriman, Fernando J Vazquez, Pierre Marie Roy, Gregoire Le Gal, Marc Carrier, Esteban Gandara
We sought to derive a parsimonious predictive model to identify a subgroup of patients that will experience a low number of adverse events within 14 days of the diagnosis of pulmonary embolism. Retrospective cohort study of adult patients with acute pulmonary embolism at the Ottawa Hospital between 2007 and 2012. Primary outcome was defined as the composite of all-cause mortality, recurrent venous thromboembolism and major bleeding within 14 days. Multivariate logistic regression models were fit to model the occurrence of the primary outcome so as to guide either outpatient therapy or early discharge after initial admission...
November 7, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27812779/a-novel-mutation-in-exon-2-of-fgb-caused-by-c-221g-t-%C3%A2-substitution-predicting-the-replacement-of-the-native-arginine-at-position-74-with-a-leucine-p-arg74leu-%C3%A2-in-a-proband-from-a-kurdish-family-with-dysfibrinogenaemia-and-familial-venous-and-arterial-thrombosis
#14
Abdul A Shlebak, Alexia D Katsarou, George Adams, Fiona Fernando
Dysfibrinogenaemias may present in either congenital or acquired form and are disorders of fibrinogen structure which may or may not be associated with abnormal function. More than 100 point mutations with single amino acid substitutions have been identified in over 400 families. These lead to defective DNA in the translated fibrinogen molecule. Such cases have improved our understanding of the fibrinogen-fibrin structure. Six members of a consanguineous family including a female proband, a female sibling, three male siblings and a daughter, with ages between 29 years and 53 years presented with early onset venous and premature arterial thromboembolic disease were investigated for a pro-thrombotic tendency associated with dysfibrinogenaemia...
November 3, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27804001/systemic-thrombolysis-in-acute-pulmonary-embolism-also-a-matter-of-time
#15
LETTER
Marco Zuin, Loris Roncon
No abstract text is available yet for this article.
November 1, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27804000/novel-sila-amide-derivatives-of-n-acetylcysteine-protects-platelets-from-oxidative-stress-induced-apoptosis
#16
Manoj Paul, Ram M Thushara, Swamy Jagadish, Uzma I Zakai, Robert West, Kempaiah Kemparaju, Kesturu S Girish
Oxidative stress-induced platelet apoptosis is one among the many causes for the development and progression of many disorders like cardiovascular diseases, arthritis, Alzheimer's disease and many chronic inflammatory responses. Many studies have demonstrated the less optimal effect of N-acetyl cysteine (NAC) in oxidative stress-induced cellular damage. This could be due to its less lipophilicity which makes it difficult to enter the cellular membrane. Therefore in the present study, lipophilic sila-amide derivatives (6a and 6b) synthesized through the reaction of NAC with 3-Aminopropyltrimethylsilane and aminomethyltrimethylsilane were used to determine their protective property against oxidative stress-induced platelet apoptosis...
November 1, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27803999/use-of-an-extended-inr-follow-up-interval-for-veteran-patients-in-an-anticoagulation-clinic
#17
Andrea L Porter, Amanda R Margolis, Rebecca R Schoen, Carla E Staresinic, Cheryl A Ray, Christopher D Fletcher
A prospective, single-arm study of 50 participants evaluated an extended INR follow-up interval to determine the implementation feasibility and safety of an extended interval in Veterans on a stable dose of warfarin. A protocol was designed to allow for a rigorous, yet pragmatic evaluation of a 12-week INR follow-up interval. Feasibility was determined by study enrollment, retention, and participant achievement rates for the extended INR interval. Safety was determined by bleeding and thromboembolism rates...
November 1, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27800569/classification-of-high-risk-with-cardiac-troponin-and-shock-index-in-normotensive-patients-with-pulmonary-embolism
#18
Savas Ozsu, Muge Erbay, Zerrin Gürel Durmuş, Tevfik Ozlu
Accurate risk stratification of normotensive patients with acute pulmonary embolism (PE) require further investigation. We aimed to develop a simple model using clinical (shock index) and laboratory findings (cardiac Troponin, echocardiography) to assess the risk of 30-day mortality in normotensive patients with acute PE. In this retrospective study, 489 normotensive patients with acute PE diagnosed objectively. The primary end-point was defined as a all cause 30-day mortality. Shock index was calculated on admission...
October 31, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27798792/bleeding-risk-associated-with-eptifibatide-integrilin-bridging-in-thoracic-surgery-patients
#19
Nathan H Waldron, Torijaun Dallas, Loretta Erhunmwunsee, Tracy Y Wang, Mark F Berry, Ian J Welsby
Antiplatelet use for treatment of coronary artery disease (CAD) is common amongst thoracic surgery patients. Perioperative management of antiplatelet agents requires balancing the opposing risks of myocardial ischemia and excessive bleeding. Perioperative bridging with short-acting intravenous antiplatelet agents has shown promise in preventing myocardial ischemia, but may increase bleeding. We sought to determine whether perioperative bridging with eptifibatide increased bleeding associated with thoracic surgery...
October 31, 2016: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27796581/treatment-of-accidental-perianal-injection-of-topical-thrombin-with-intravenous-antithrombin
#20
Vance G Nielsen, Samata R Paidy, Whitney McLeod, Alexandra Fox, Valentine N Nfonsam
While topical thrombin application can markedly improve surgical hemostasis, rapid absorption of thrombin can result in pulmonary embolism and death. We report a case of accidental interstitial infiltration of topical thrombin after hemorrhoidectomy that was treated with administration of human antithrombin and heparin anticoagulation. Except for a marked decrease in antithrombin activity from super normal to normal values, the patient exhibited no laboratory or clinical signs of pulmonary embolism, thrombin mediated consumptive loss of procoagulants, or regional thrombosis...
October 28, 2016: Journal of Thrombosis and Thrombolysis
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