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Journal of Thrombosis and Thrombolysis

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https://www.readbyqxmd.com/read/29785470/four-factor-prothrombin-complex-concentrate-for-warfarin-reversal-in-patients-with-left-ventricular-assist-devices
#1
Jessica Rimsans, Amy Levesque, Erin Lyons, Katelyn Sylvester, Michael M Givertz, Mandeep R Mehra, Garrick C Stewart, Jean M Connors
Continuous flow left ventricular assist devices (CF-LVAD) require therapeutic anticoagulation which is often interrupted for procedures or bleeding. Prior to the availability of four factor prothrombin complex concentrate (4F-PCC) in the United States, warfarin was held and its effects reversed by vitamin K or fresh frozen plasma. We evaluated the use of 4F-PCC for temporary warfarin reversal in patients with CF-LVADs and assessed outcomes. This analysis is a retrospective study of CF-LVAD patients who received 4F-PCC for warfarin reversal in the setting of bleeding or need for urgent or elective procedures...
May 21, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29774488/the-effect-of-oxygen-in-sirt3-mediated-myocardial-protection-a-proof-of-concept-study-in-cultured-cardiomyoblasts
#2
Philipp Diehl, Daniel S Gaul, Jonas Sogl, Ulrike Flierl, Darren Henstridge, Juergen Pahla, Heiko Bugger, Maximilian Y Emmert, Frank Ruschitzka, Christoph Bode, Thomas F Lüscher, Martin Moser, Christian M Matter, Karlheinz Peter, Stephan Winnik
Sirtuin 3 is a nicotinamide adenine dinucleotide dependent mitochondrial deacetylase that governs mitochondrial metabolism and oxidative defense. The demise in myocardial function following myocardial ischemia has been associated with mitochondrial dysfunction. Sirt3 maintains myocardial contractile function and protects from cardiac hypertrophy. The role of Sirt3 in ischemia is controversial. Our objective was to understand, under what circumstances Sirt3 is protective in different facets of ischemia, using an in vitro proof-of-concept approach based on simulated ischemia in cultured cardiomyoblasts...
May 17, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29761426/predictors-of-self-reported-adherence-to-direct-oral-anticoagulation-in-a-population-of-elderly-men-and-women-with-non-valvular-atrial-fibrillation
#3
Andrea P Rossi, Roberto Facchinetti, Elena Ferrari, Nicole Nori, Selena Sant, Elena Masciocchi, Elena Zoico, Francesco Fantin, Gloria Mazzali, Mauro Zamboni
There is a general lack of studies evaluating medication adherence with self-report scales for elderly patients in treatment with direct oral anticoagulants (DOACs). The aim of the study was to assess the degree of adherence to DOAC therapy in a population of elderly outpatients aged 65 years or older affected by non-valvular atrial fibrillation (NVAF), using the 4-item Morisky Medication Adherence Scale, and to identify potential factors, including the geriatric multidimensional evaluation, which can affect adherence in the study population...
May 14, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29748776/distinctive-regional-specific-pros1-mutation-spectrum-in-southern-china
#4
LETTER
Nelson C N Chan, Chi-Keung Cheng, Kelvin C F Chan, Connie M L Wong, Kin-Mang Lau, Joyce H Y Kwong, Natalie P H Chan, Wai-Shan Wong, Eudora Y D Chow, Michael L G Wong, Raymond W Chu, Rosalina K L Ip, Margaret H L Ng
No abstract text is available yet for this article.
May 10, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29748775/congenital-hypodysfibrinogenemia-associated-with-a-novel-deletion-of-three-residues-%C3%AE-ala289_asp291del-in-fibrinogen
#5
Liqing Zhu, Misheng Zhao, Mingshan Wang, Zhefeng Lou, Xiaoli Chen, Liangliang Pan, Dandan Yu, Wenli Xia, Han Wang, Bin Zhou, Shenmeng Gao
Hypodysfibrinogenemia is the least frequently reported congenital fibrinogen disorder, characterized by both quantity and quality defects of fibrinogen. In this study, we investigated the molecular basis of hypodysfibrinogenemia in a Chinese family. Functional fibrinogen was measured by Clauss method, and the antigenic fibrinogen was measured by immunoturbidimetry assay. All the exons and exon-intron boundaries of fibrinogen genes (FGA, FGB and FGG) were analysed by direct DNA sequencing. To further evaluate its molecular and functional characterizations, fibrinogen was purified from the plasma of propositus, then SDS-PAGE, fibrin polymerization, clot lysis, and electron microscopy scanning were all performed...
May 10, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29740732/successful-treatment-with-idarucizumab-for-diffuse-alveolar-hemorrhage-induced-by-dabigatran-etexilate-a-case-report
#6
Akihiro Shiroshita, Kei Nakashima, Yu Tanaka, Akiko Tateishi, Masahiro Nemoto, Masahiro Aoshima
We report the case of an 81-year-old man taking dabigatran etexilate (dabigatran) for chronic atrial fibrillation, who presented with acute-onset hemoptysis and hypoxia. Chest high-resolution computed tomography showed bilateral ground grass opacities. After admission, his respiratory failure progressed rapidly and bronchoalveolar lavage was performed immediately, which showed copious amounts of bloody fluid and hemosiderin-laden macrophages with Prussian blue staining. He was diagnosed as having diffuse alveolar hemorrhage (DAH)...
May 8, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29740731/evaluation-of-doac-measurement-on-the-cs-5100-using-the-innovance%C3%A2-heparin-and-innovance%C3%A2-dti-reagent
#7
LETTER
Tobias Flieder, Andreas Hammerschmidt, Joachim Kuhn, Cornelius Knabbe, Ingvild Birschmann
No abstract text is available yet for this article.
May 8, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29737462/validation-of-plasmic-score-and-follow-up-data-in-a-cohort-of-patients-with-suspected-microangiopathies-from-southern-italy
#8
Giovanni Luca Tiscia, Angelo Ostuni, Nicola Cascavilla, Filomena Cappucci, Potito Scalzulli, Cosima Battista, Antonio Abrescia, Filippo Aucella, Caterina Buquicchio, Maurizio Brigante, Giovanna D'Andrea, Bruno Di Paolo, Giulio Giordano, Barbara Infante, Silvia Piano, Prudenza Ranieri, Livio Tullo, Elvira Grandone
Severe ADAMTS13 deficiency (activity < 10%) is pathognomonic of thrombotic thrombocytopenic purpura. ADAMTS13 testing is time-consuming and unavailable in many hospitals. Recently, a seven-variables score named PLASMIC score, has been developed to stratify acute patients, based on their risk of having a severe ADAMTS13 deficiency. We present the application of this score in a cohort of patients referred to our Center. From 2012 to 2017, 42 patients with suspected thrombotic microangiopathies from 6 Centers were referred to Hemostasis and Thrombosis Center of "Casa Sollievo della Sofferenza" Hospital/Research Institute for ADAMTS13 testing...
May 8, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29728838/interaction-between-nonsynonymous-polymorphisms-in-pla2g7-gene-and-smoking-on-the-risk-of-coronary-heart-disease-in-a-chinese-population
#9
Yunpeng Chi, Conghong Shi, Xiaojiang Zhang, Yang Xi
To investigate the impact of PLA2G7 polymorphism, and additional their interactions with smoking and drinking on coronary heart disease (CHD) risk based on Chinese population. GMDR model was used to screen the best gene-smoking and gene-drinking interaction combinations. Logistic regression was performed to investigate association between 4 SNPs and CHD, and the interaction effect between rs1805017 and smoking. For CHD patient-control haplotype analyses, the SHEsis online haplotype analysis software ( http://analysis...
May 4, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29713925/antiphospholipid-antibody-profile-based-outcome-of-purely-vascular-and-purely-obstetric-antiphospholipid-syndrome
#10
Amihai Rottenstreich, Ariela Arad, Hadas Terespolsky, Uriel Elchalal, Hagai Amsalm, Batia Roth, Yosef Kalish
Antiphospholipid syndrome (APLS) is caused by antiphospholipid autoantibodies, and manifests with vascular and/or obstetric complications. The factors associated with initial disease presentation and course are unknown. We assessed the antibody profile associated with disease presentation and with the development of vascular and obstetric complications in women with initially vascular or initially obstetric APLS. A review of records of APLS women at childbearing age followed at one center during 2006-2015. Of 126 women, median age at diagnosis 29 [23-37] years, 62 were initially diagnosed with purely obstetric APLS and 64 with purely vascular APLS...
April 30, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29704172/a-direct-oral-factor-xa-inhibitor-edoxaban-ameliorates-neointimal-hyperplasia-following-vascular-injury-and-thrombosis-in-apolipoprotein-e-deficient-mice
#11
Yoshiyuki Morishima, Yuko Honda
Vascular injury activates the coagulation cascade. Some studies report that coagulation factor Xa and thrombin are implicated in proliferation of vascular smooth muscle cells and neointimal hyperplasia after vascular injury. The aim of this study was to determine the effect of an oral direct factor Xa inhibitor, edoxaban, on neointimal hyperplasia following the carotid artery injury in apolipoprotein E (ApoE)-deficient mice. Vascular injury was induced by the application of 10% ferric chloride to the carotid artery for 3 min in ApoE-deficient mice...
April 27, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29687300/anemia-and-bleeding-in-patients-receiving-anticoagulant-therapy-for-venous-thromboembolism-comment
#12
LETTER
Yoann Gaboreau, Nora Zenatti, Céline Vermorel, Patrick Imbert, Jean-Luc Bosson, Gilles Pernod
Kuperman et al. found that patients with anemia had a higher risk of major bleeding (RR 2.84; 95% CI 2.52-3.39) in RIETE database. Anemia appeared to be an independent predictive factor for major bleeding [hazard ratio (HR) 1.95; 95% CI 1.72-2.20] in this registry. Unfortunately, selection bias due to enrolled patients does not allowed us to use these major results in ambulatory care. The aim of SCORE study was to refine bleeding risk estimation in French vitamin K antagonist (VKA) treated patients and to identifying one or several parameters of prognostic significance...
April 23, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29687299/anticoagulation-reversal-in-vitamin-k-antagonist-associated-intracerebral-hemorrhage-a-systematic-review
#13
Darae Ko, Zayd Razouki, James Otis, Erika Marulanda-Londoño, Elaine M Hylek
The effect of rapid anticoagulation reversal on mortality and functional outcome in vitamin K antagonist-associated intracerebral hemorrhage (VKA-ICH) is uncertain. Given the approval of idarucizumab for dabigatran reversal and pending approval for andexanet alfa for reversal of factor Xa inhibitors, a systematic appraisal of the effectiveness of reversal for VKA-ICH would provide a bench mark for current practice. We performed PubMed searches and reviewed current guidelines. Using pre-specified inclusion and exclusion criteria, studies were reviewed by two physicians independently...
April 23, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29681002/the-influence-of-fibrate-initiation-on-inr-and-warfarin-dose-in-patients-receiving-chronic-warfarin-therapy
#14
John F Polnak, Thomas Delate, Nathan P Clark
Several drug interaction compendia report a risk of warfarin potentiation after initiation of a fibrate; however, the evidence of this interaction is limited. The objective of this study was to evaluate warfarin dose and international normalized ratio (INR) response among a large sample of patients receiving chronic warfarin who initiated a fibrate. This was a retrospective, one-sample, pre-to-post study. Adult patients who were receiving chronic warfarin therapy at the time of gemfibrozil or fenofibrate dispensing between 1/1/2000 and 3/31/2016 were included...
April 21, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29679257/anticoagulant-related-nephropathy-a-pathological-note
#15
LETTER
Vincenzo L'Imperio, Alessia Guarnieri, Federico Pieruzzi, Renato Alberto Sinico, Fabio Pagni
The wide employment of oral anticoagulants and the introduction of new anticoagulant agents highlight disparate kind of toxicities that can affect many different organ systems. Renal toxicity by oral anticoagulants is a well-known entity characterized by hematuria and the worsening of renal function associated with uncontrolled INR values. Although it is mainly a clinical diagnosis, renal biopsy may help especially in challenging cases when multiple comorbidities and underlying renal conditions exist. The mechanism of the anticoagulant-induced damage is still debated and special tissue stains (such as Perls') could help in detecting the direct tubular toxicity induced by chronic glomerular bleeding...
April 20, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29675617/is-acute-pulmonary-embolism-more-severe-in-the-presence-of-obstructive-sleep-apnea-results-from-an-observational-cohort-study
#16
Dinah Konnerth, Florian Schwarz, Michael Probst, Martin Seidler, Tanja Wagner, Christian Faul, Wolfgang von Scheidt, Martin Schwaiblmair, Thomas M Berghaus
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0...
April 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29671165/polymorphisms-in-park2-and-mrpl37-are-associated-with-higher-risk-of-recurrent-venous-thromboembolism-in-a-sex-specific-manner
#17
Kristina Sundquist, Abrar Ahmad, Peter J Svensson, Bengt Zöller, Jan Sundquist, Ashfaque A Memon
Recent studies indicate that mitochondrial DNA (mtDNA) dysfunction is a biomarker of oxidative stress and can predict the risk of cardiovascular diseases (CVDs). Genetic variants in PARK2 (rs4708928) and MRPL37 (rs10888838) genes have been shown to be associated with altered levels of mtDNA in a sex-specific manner. However, the role of these genetic variants in risk assessment of recurrent venous thromboembolism (VTE) is unknown. We investigated the role of these polymorphisms in VTE recurrence in patients from the Malmö thrombophilia study (MATS, n = 1465), followed for ~ 10 years...
April 18, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29671164/the-role-of-antiplatelet-drug-resistance-in-subclinical-leaflet-thrombosis-following-transcatheter-aortic-valve-replacement
#18
LETTER
Hashrul N Rashid, Paul Thein, Arthur Nasis
No abstract text is available yet for this article.
April 18, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29667126/treatment-of-submassive-and-massive-pulmonary-embolism-a-clinical-practice-survey-from-the-second-annual-meeting-of-the-pulmonary-embolism-response-team-consortium
#19
Thomas M Todoran, Jay Giri, Geoffrey D Barnes, Rachel P Rosovsky, Yuchiao Chang, Michael R Jaff, Kenneth Rosenfield, Christopher Kabrhel
There is a paucity of robust clinical trial data to guide the treatment of acute pulmonary embolism (PE) thus the clinical guidelines rely heavily on expert opinion. Pulmonary Embolism Response Teams (PERT) have been developed to streamline the care of patients with acute PE. We conducted a survey among 100 experts in the field of PE during the second annual meeting of the PERT Consortium. Respondents were queried with respect to their demographic information, clinical practice questions and clinical vignettes...
April 17, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29654448/the-course-of-acquired-von-willebrand-syndrome-during-pregnancy-among-patients-with-essential-thrombocytosis
#20
Amihai Rottenstreich, Geffen Kleinstern, Hagai Amsalem, Yosef Kalish
To investigate the course of acquired type 2A von Willebrand syndrome (AVWS) in relation to patient management and outcomes among pregnant patients with essential thrombocytosis (ET). A review of pregnant women with ET evaluated for AVWS at the beginning of pregnancy and at the third trimester. Eighteen women with 24 pregnancies were included in this study. A history of bleeding was noted in 8 (44%) patients. In 20 (83%) pregnancies AVWS was evident at the initial testing. Following initial testing, antithrombotic therapy was administered in 22 (92%) pregnancies (aspirin, n = 20 and low-molecular-weight heparin, n = 2)...
April 13, 2018: Journal of Thrombosis and Thrombolysis
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