journal
MENU ▼
Read by QxMD icon Read
search

Nature Medicine

journal
https://www.readbyqxmd.com/read/29934536/publisher-correction-stimulation-of-entorhinal-cortex-dentate-gyrus-circuitry-is-antidepressive
#1
Sanghee Yun, Ryan P Reynolds, Iraklis Petrof, Alicia White, Phillip D Rivera, Amir Segev, Adam D Gibson, Maiko Suarez, Matthew J DeSalle, Naoki Ito, Shibani Mukherjee, Devon R Richardson, Catherine E Kang, Rebecca C Ahrens-Nicklas, Ivan Soler, Dane M Chetkovich, Saïd Kourrich, Douglas A Coulter, Amelia J Eisch
In the version of this article originally published, a URL provided in the Methods section was incorrect. The URL had a solidus at the end but should have appeared as http://www.nature.com/authors/policies/image.html. The error has been corrected in the PDF and HTML versions of this article.
June 22, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29934535/publisher-correction-thymosin-%C3%AE-1-represents-a-potential-potent-single-molecule-based-therapy-for-cystic-fibrosis
#2
Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci
In the version of this article originally published, the amino acid sequence for Tα1 described in the Online Methods is incorrect. The sequence is described as "Ac-SDAAVDTSSEITTJDLKEKKEVVEEAEN-OH". It should be "Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH". The error has been corrected in the HTML and PDF versions of this article.
June 22, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29934534/author-correction-thymosin-%C3%AE-1-represents-a-potential-potent-single-molecule-based-therapy-for-cystic-fibrosis
#3
Luigina Romani, Vasilis Oikonomou, Silvia Moretti, Rossana G Iannitti, Maria Cristina D'Adamo, Valeria R Villella, Marilena Pariano, Luigi Sforna, Monica Borghi, Marina M Bellet, Francesca Fallarino, Maria Teresa Pallotta, Giuseppe Servillo, Eleonora Ferrari, Paolo Puccetti, Guido Kroemer, Mauro Pessia, Luigi Maiuri, Allan L Goldstein, Enrico Garaci
In the version of this article originally published, some labels in Fig. 1f are incorrect. The "β-actin" labels on the second and fourth rows of blots should instead be "β-tubulin". The error has been corrected in the HTML and PDF versions of this article.
June 22, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29921958/author-correction-stat3-labels-a-subpopulation-of-reactive-astrocytes-required-for-brain-metastasis
#4
Neibla Priego, Lucía Zhu, Cátia Monteiro, Manon Mulders, David Wasilewski, Wendy Bindeman, Laura Doglio, Liliana Martínez, Elena Martínez-Saez, Santiago Ramón Y Cajal, Diego Megías, Elena Hernández-Encinas, Carmen Blanco-Aparicio, Lola Martínez, Eduardo Zarzuela, Javier Muñoz, Coral Fustero-Torre, Elena Piñeiro-Yáñez, Aurelio Hernández-Laín, Luca Bertero, Valeria Poli, Melchor Sanchez-Martinez, Javier A Menendez, Riccardo Soffietti, Joaquim Bosch-Barrera, Manuel Valiente
In the version of this article originally published, the names of three authors were incorrect. The authors were listed as "Coral Fustero-Torres", "Elena Pineiro" and "Melchor Sánchez-Martínez". Their respective names are "Coral Fustero-Torre", "Elena Piñeiro-Yáñez" and "Melchor Sanchez-Martinez". The errors have been corrected in the print, HTML and PDF versions of this article.
June 19, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29915259/low-frequency-cortical-activity-is-a-neuromodulatory-target-that-tracks-recovery-after-stroke
#5
Dhakshin S Ramanathan, Ling Guo, Tanuj Gulati, Gray Davidson, April K Hishinuma, Seok-Joon Won, Robert T Knight, Edward F Chang, Raymond A Swanson, Karunesh Ganguly
Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex...
June 18, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29895835/publisher-correction-targeting-hepatic-glutaminase-activity-to-ameliorate-hyperglycemia
#6
Russell A Miller, Yuji Shi, Wenyun Lu, David A Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, César Cárdenas, Min Wan, J Kevin Foskett, Junyoung O Park, Yiyi Zhang, William L Holland, Joshua D Rabinowitz, Morris J Birnbaum
In the version of this article initially published, the "[13C2]α-ketoglutarate" label on Fig. 1g is incorrect. It should be "[13C5]α-ketoglutarate". Additionally, in Fig. 3b, the "AAV-GFP" group is missing a notation for significance, and in Fig. 3c, the "AAV-GLS2-sh" group is missing a notation for significance. There should be a double asterisk notating significance in both panels. Finally, in the Fig. 4g legend, "[13C6]UDP-glucose" should be "[13C3]UDP-glucose", and in the Fig...
June 12, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892070/an-inhibitor-of-oxidative-phosphorylation-exploits-cancer-vulnerability
#7
Jennifer R Molina, Yuting Sun, Marina Protopopova, Sonal Gera, Madhavi Bandi, Christopher Bristow, Timothy McAfoos, Pietro Morlacchi, Jeffrey Ackroyd, Ahmed-Noor A Agip, Gheath Al-Atrash, John Asara, Jennifer Bardenhagen, Caroline C Carrillo, Christopher Carroll, Edward Chang, Stefan Ciurea, Jason B Cross, Barbara Czako, Angela Deem, Naval Daver, John Frederick de Groot, Jian-Wen Dong, Ningping Feng, Guang Gao, Jason Gay, Mary Geck Do, Jennifer Greer, Virginia Giuliani, Jing Han, Lina Han, Verlene K Henry, Judy Hirst, Sha Huang, Yongying Jiang, Zhijun Kang, Tin Khor, Sergej Konoplev, Yu-Hsi Lin, Gang Liu, Alessia Lodi, Timothy Lofton, Helen Ma, Mikhila Mahendra, Polina Matre, Robert Mullinax, Michael Peoples, Alessia Petrocchi, Jaime Rodriguez-Canale, Riccardo Serreli, Thomas Shi, Melinda Smith, Yoko Tabe, Jay Theroff, Stefano Tiziani, Quanyun Xu, Qi Zhang, Florian Muller, Ronald A DePinho, Carlo Toniatti, Giulio F Draetta, Timothy P Heffernan, Marina Konopleva, Philip Jones, M Emilia Di Francesco, Joseph R Marszalek
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to an incomplete understanding of tumor contexts in which OXPHOS is essential. Here, we report the discovery of IACS-010759, a clinical-grade small-molecule inhibitor of complex I of the mitochondrial electron transport chain...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892069/stat3-labels-a-subpopulation-of-reactive-astrocytes-required-for-brain-metastasis
#8
Neibla Priego, Lucía Zhu, Cátia Monteiro, Manon Mulders, David Wasilewski, Wendy Bindeman, Laura Doglio, Liliana Martínez, Elena Martínez-Saez, Santiago Ramón Y Cajal, Diego Megías, Elena Hernández-Encinas, Carmen Blanco-Aparicio, Lola Martínez, Eduardo Zarzuela, Javier Muñoz, Coral Fustero-Torres, Elena Pineiro, Aurelio Hernández-Laín, Luca Bertero, Valeria Poli, Melchor Sánchez-Martínez, Javier A Menendez, Riccardo Soffietti, Joaquim Bosch-Barrera, Manuel Valiente
The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of this microenvironment that confine brain metastasis without infiltrating the lesion. Here, we describe that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by signal transducer and activator of transcription 3 (STAT3) in a subpopulation of reactive astrocytes surrounding metastatic lesions...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892068/suppression-of-detyrosinated-microtubules-improves-cardiomyocyte-function-in-human-heart-failure
#9
Christina Yingxian Chen, Matthew A Caporizzo, Kenneth Bedi, Alexia Vite, Alexey I Bogush, Patrick Robison, Julie G Heffler, Alex K Salomon, Neil A Kelly, Apoorva Babu, Michael P Morley, Kenneth B Margulies, Benjamin L Prosser
Detyrosinated microtubules provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in heart failure or in human hearts have not previously been studied. Here, we utilize mass spectrometry and single-myocyte mechanical assays to characterize changes to the cardiomyocyte cytoskeleton and their functional consequences in human heart failure. Proteomic analysis of left ventricle tissue reveals a consistent upregulation and stabilization of intermediate filaments and microtubules in failing human hearts...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892067/crispr-cas9-genome-editing-induces-a-p53-mediated-dna-damage-response
#10
Emma Haapaniemi, Sandeep Botla, Jenna Persson, Bernhard Schmierer, Jussi Taipale
Here, we report that genome editing by CRISPR-Cas9 induces a p53-mediated DNA damage response and cell cycle arrest in immortalized human retinal pigment epithelial cells, leading to a selection against cells with a functional p53 pathway. Inhibition of p53 prevents the damage response and increases the rate of homologous recombination from a donor template. These results suggest that p53 inhibition may improve the efficiency of genome editing of untransformed cells and that p53 function should be monitored when developing cell-based therapies utilizing CRISPR-Cas9...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892066/block-of-a1-astrocyte-conversion-by-microglia-is-neuroprotective-in-models-of-parkinson-s-disease
#11
Seung Pil Yun, Tae-In Kam, Nikhil Panicker, SangMin Kim, Yumin Oh, Jong-Sung Park, Seung-Hwan Kwon, Yong Joo Park, Senthilkumar S Karuppagounder, Hyejin Park, Sangjune Kim, Nayeon Oh, Nayoung Alice Kim, Saebom Lee, Saurav Brahmachari, Xiaobo Mao, Jun Hee Lee, Manoj Kumar, Daniel An, Sung-Ung Kang, Yunjong Lee, Kang Choon Lee, Dong Hee Na, Donghoon Kim, Sang Hun Lee, Viktor V Roschke, Shane A Liddelow, Zoltan Mari, Ben A Barres, Valina L Dawson, Seulki Lee, Ted M Dawson, Han Seok Ko
Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases1,2 . Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat these diseases for which there are no disease-modifying therapies. Glucagon-like peptide-1 receptor (GLP1R) agonists have been indicated as potential neuroprotective agents for neurologic disorders such as Alzheimer's disease and Parkinson's disease3-13 ...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892065/a-transcriptionally-and-functionally-distinct-pd-1-cd8-t-cell-pool-with-predictive-potential-in-non-small-cell-lung-cancer-treated-with-pd-1-blockade
#12
Daniela S Thommen, Viktor H Koelzer, Petra Herzig, Andreas Roller, Marcel Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christian Klein, Vaios Karanikas, Kirsten D Mertz, Ton N Schumacher, Alfred Zippelius
Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels. We compared transcriptional, metabolic and functional signatures of intratumoral CD8+ T lymphocyte populations with high (PD-1T ), intermediate (PD-1N ) and no PD-1 expression (PD-1- ) from non-small-cell lung cancer patients...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892064/the-human-heart-contains-distinct-macrophage-subsets-with-divergent-origins-and-functions
#13
Geetika Bajpai, Caralin Schneider, Nicole Wong, Andrea Bredemeyer, Maarten Hulsmans, Matthias Nahrendorf, Slava Epelman, Daniel Kreisel, Yongjian Liu, Akinobu Itoh, Thirupura S Shankar, Craig H Selzman, Stavros G Drakos, Kory J Lavine
Paradigm-shifting studies in the mouse have identified tissue macrophage heterogeneity as a critical determinant of immune responses. In contrast, surprisingly little is known regarding macrophage heterogeneity in humans. Macrophages within the mouse heart are partitioned into CCR2- and CCR2+ subsets with divergent origins, repopulation mechanisms, and functions. Here, we demonstrate that the human myocardium also contains distinct subsets of CCR2- and CCR2+ macrophages. Analysis of sex-mismatched heart transplant recipients revealed that CCR2- macrophages are a tissue-resident population exclusively replenished through local proliferation, whereas CCR2+ macrophages are maintained through monocyte recruitment and proliferation...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892063/rapid-hiv-rna-rebound-after-antiretroviral-treatment-interruption-in-persons-durably-suppressed-in-fiebig-i-acute-hiv-infection
#14
Donn J Colby, Lydie Trautmann, Suteeraporn Pinyakorn, Louise Leyre, Amélie Pagliuzza, Eugène Kroon, Morgane Rolland, Hiroshi Takata, Supranee Buranapraditkun, Jintana Intasan, Nitiya Chomchey, Roshell Muir, Elias K Haddad, Sodsai Tovanabutra, Sasiwimol Ubolyam, Diane L Bolton, Brandie A Fullmer, Robert J Gorelick, Lawrence Fox, Trevor A Crowell, Rapee Trichavaroj, Robert O'Connell, Nicolas Chomont, Jerome H Kim, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892062/p53-inhibits-crispr-cas9-engineering-in-human-pluripotent-stem-cells
#15
Robert J Ihry, Kathleen A Worringer, Max R Salick, Elizabeth Frias, Daniel Ho, Kraig Theriault, Sravya Kommineni, Julie Chen, Marie Sondey, Chaoyang Ye, Ranjit Randhawa, Tripti Kulkarni, Zinger Yang, Gregory McAllister, Carsten Russ, John Reece-Hoyes, William Forrester, Gregory R Hoffman, Ricardo Dolmetsch, Ajamete Kaykas
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1-3 . Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cells (hPSCs) have been difficult to engineer, with reduced efficiencies relative to tumour cell lines or mouse embryonic stem cells3-13 . Here, using hPSC lines with stable integration of Cas9 or transient delivery of Cas9-ribonucleoproteins (RNPs), we achieved an average insertion or deletion (indel) efficiency greater than 80%...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892060/dna-repair-processes-are-critical-mediators-of-p53-dependent-tumor-suppression
#16
Ana Janic, Liz J Valente, Matthew J Wakefield, Leon Di Stefano, Liz Milla, Stephen Wilcox, Haoyu Yang, Lin Tai, Cassandra J Vandenberg, Andrew J Kueh, Shinsuke Mizutani, Margs S Brennan, Robyn L Schenk, Lisa M Lindqvist, Anthony T Papenfuss, Liam O'Connor, Andreas Strasser, Marco J Herold
It has long been assumed that p53 suppresses tumor development through induction of apoptosis, possibly with contributions by cell cycle arrest and cell senescence1,2 . However, combined deficiency in these three processes does not result in spontaneous tumor formation as observed upon loss of p53, suggesting the existence of additional mechanisms that are critical mediators of p53-dependent tumor suppression function3-5 . To define such mechanisms, we performed in vivo shRNA screens targeting p53-regulated genes in sensitized genetic backgrounds...
June 11, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29892061/mutations-in-the-swi-snf-complex-induce-a-targetable-dependence-on-oxidative-phosphorylation-in-lung-cancer
#17
Yonathan Lissanu Deribe, Yuting Sun, Christopher Terranova, Fatima Khan, Juan Martinez-Ledesma, Jason Gay, Guang Gao, Robert A Mullinax, Tin Khor, Ningping Feng, Yu-Hsi Lin, Chia-Chin Wu, Claudia Reyes, Qian Peng, Frederick Robinson, Akira Inoue, Veena Kochat, Chang-Gong Liu, John M Asara, Cesar Moran, Florian Muller, Jing Wang, Bingliang Fang, Vali Papadimitrakopoulou, Ignacio I Wistuba, Kunal Rai, Joseph Marszalek, P Andrew Futreal
Lung cancer is a devastating disease that remains a top cause of cancer mortality. Despite improvements with targeted and immunotherapies, the majority of patients with lung cancer lack effective therapies, underscoring the need for additional treatment approaches. Genomic studies have identified frequent alterations in components of the SWI/SNF chromatin remodeling complex including SMARCA4 and ARID1A. To understand the mechanisms of tumorigenesis driven by mutations in this complex, we developed a genetically engineered mouse model of lung adenocarcinoma by ablating Smarca4 in the lung epithelium...
June 8, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29867235/epitope-based-vaccine-design-yields-fusion-peptide-directed-antibodies-that-neutralize-diverse-strains-of-hiv-1
#18
Kai Xu, Priyamvada Acharya, Rui Kong, Cheng Cheng, Gwo-Yu Chuang, Kevin Liu, Mark K Louder, Sijy O'Dell, Reda Rawi, Mallika Sastry, Chen-Hsiang Shen, Baoshan Zhang, Tongqing Zhou, Mangaiarkarasi Asokan, Robert T Bailer, Michael Chambers, Xuejun Chen, Chang W Choi, Venkata P Dandey, Nicole A Doria-Rose, Aliaksandr Druz, Edward T Eng, S Katie Farney, Kathryn E Foulds, Hui Geng, Ivelin S Georgiev, Jason Gorman, Kurt R Hill, Alexander J Jafari, Young D Kwon, Yen-Ting Lai, Thomas Lemmin, Krisha McKee, Tiffany Y Ohr, Li Ou, Dongjun Peng, Ariana P Rowshan, Zizhang Sheng, John-Paul Todd, Yaroslav Tsybovsky, Elise G Viox, Yiran Wang, Hui Wei, Yongping Yang, Amy F Zhou, Rui Chen, Lu Yang, Diana G Scorpio, Adrian B McDermott, Lawrence Shapiro, Bridget Carragher, Clinton S Potter, John R Mascola, Peter D Kwong
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptide-coupled carriers and prefusion stabilized envelope trimers, induces cross-clade neutralizing responses. In mice, these immunogens elicited monoclonal antibodies capable of neutralizing up to 31% of a cross-clade panel of 208 HIV-1 strains...
June 4, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29867234/targeting-the-cancer-mutanome-of-breast-cancer
#19
Laszlo G Radvanyi
No abstract text is available yet for this article.
June 4, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29867233/impact-of-neutralizing-antibodies-against-aav-is-a-key-consideration-in-gene-transfer-to-nonhuman-primates
#20
LETTER
Weidong Xiao, Guangping Gao, Chen Ling, Roland W Herzog, Xiao Xiao, Richard J Samulski
No abstract text is available yet for this article.
June 4, 2018: Nature Medicine
journal
journal
32162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"