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Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research

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https://www.readbyqxmd.com/read/30217834/external-validation-of-the-accuracy-of-cllflow-score
#1
Giovanni D'Arena, Candida Vitale, Marta Coscia, Fiorella D'Auria, Silvia Bellesi, Giuseppe Topini, Valentina Panichi, Luciana Valvano, Teodora Statuto, Francesco Corrente, Luca Laurenti
No abstract text is available yet for this article.
September 14, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30158166/high-power-doppler-ultrasound-score-is-associated-with-the-risk-of-triangular-fibrocartilage-complex-tfcc-tears-in-severe-rheumatoid-arthritis
#2
Jen-Hung Chen, Kuo-Chin Huang, Chung-Cheng Huang, Han-Ming Lai, Wen-Yi Chou, Ying-Chou Chen
In the distal radioulnar joint, the triangular fibrocartilage complex (TFCC) is an important stabilizer and are frequently found in patients with rheumatoid arthritis (RA) with wrist pain. This study was designed to predict TFCC tears using high-resolution ultrasound in severe RA. We retrospectively reviewed patients with severe RA. MRI and ultrasound were performed at baseline and after 1 year of follow-up. TFCC tears were recorded. The predictive factors for TFCC tears were analyzed by logistic regression...
August 29, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30127099/development-and-validation-of-nomogram-based-on-siri-for-predicting-the-clinical-outcome-in-patients-with-nasopharyngeal-carcinomas
#3
Yuan Chen, Wenjie Jiang, Dan Xi, Jun Chen, Guoping Xu, Wenming Yin, Junjun Chen, Wendong Gu
The Systemic Inflammation Response Index (SIRI), based on peripheral lymphocyte, neutrophil, and monocyte counts, was recently investigated as a prognostic marker for several tumors. However, use of the SIRI has not been reported for nasopharyngeal carcinoma (NPC). We evaluated the prognostic value of the SIRI in primary and validation cohorts. We also established an effective prognostic nomogram for NPC based on clinicopathological parameters and the SIRI. The predictive accuracy and discriminative ability of the nomogram were determined using the concordance index (C-index) and a calibration curve and were compared with tumor-node-metastasis classifications...
August 20, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30127098/new-and-emerging-therapies-for-acute-myeloid-leukaemia
#4
Julian R Davis, David J Benjamin, Brian A Jonas
The treatment of acute myeloid leukemia (AML) has remained relatively unchanged for the past 3-4 decades with generally poor outcomes, especially in elderly populations unfit for intensive therapy. Recent advancements, however, have identified several cytogenetic and molecular markers that have not only improved prognostication but have also led to the development of several new targeted therapies for specific subpopulations. In 2017, the US Food and Drug Administration approved four new treatments with indications for fms like tyrosine kinase 3 (FLT3)-mutated AML (midostaurin), newly diagnosed or relapsed/refractory CD33+AML (gemtuzumab ozogamicin), newly diagnosed therapy-related AML or AML with myelodysplasia-related changes (CPX-351) and relapsed/refractory AML with an isocitrate dehydrogenase (IDH)2 mutation (enasidenib)...
August 19, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30097466/patterns-of-desmin-expression-in-idiopathic-dilated-cardiomyopathy-are-related-to-the-desmin-mrna-and-ubiquitin-expression
#5
Agnieszka Pawlak, Emilia Rejmak-Kozicka, Katarzyna Elżbieta Gil, Andrzej Ziemba, Leszek Kaczmarek, Robert Julian Gil
Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomyocytes. Endomyocardial biopsy was performed in 60 patients (85% men, mean age 46±14 years) with heart failure (HF; left ventricular ejection fraction <45%). Desmin and ubiquitin expression were analysed in histological sections by immunohistochemistry and in Western blot...
August 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30042113/metabolic-and-cardiovascular-effects-of-chronic-mild-hyperuricemia-in-rodents
#6
Sun K Park, Tara R Rosenthal, Jessica S Williams, John M Shelton, Masaya Takahashi, Shanrong Zhang, Ion Alexandru Bobulescu
Mildly elevated serum uric acid levels are common in people with metabolic syndrome and type 2 diabetes mellitus (T2DM), but whether elevated uric acid has a causal role in the pathogenesis of diabetes remains uncertain. We tested whether chronic mild hyperuricemia in rodents under controlled laboratory conditions can cause glucose intolerance in otherwise healthy animals, or whether it can worsen glucometabolic control in animals that are genetically predisposed to T2DM. We used an established model of experimental hyperuricemia in rodents with potassium oxonate dietary supplementation, which led to sustained, approximately two-fold elevation of uric acid compared with control animals...
July 24, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30042112/case-control-study-examining-the-association-between-allopurinol-use-and-ischemic-cerebrovascular-disease
#7
Shih-Wei Lai, Cheng-Li Lin, Kuan-Fu Liao
Few studies focus on the relationship between allopurinol and ischemic cerebrovascular disease. The goal of the study was to investigate the association of long-term therapy of allopurinol with the first-time attack of ischemic cerebrovascular disease in Taiwan. We performed a case-control study using the database of the Taiwan National Health Insurance Program. The case group included 14,937 subjects aged 20-84 years with the first-time attack of ischemic cerebrovascular disease from 2000 to 2013. The control group included 14,937 sex-matched and age-matched subjects aged 20-84 years without any type of cerebrovascular disease...
July 24, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30042111/patient-and-hospital-factors-associated-with-30-day-unplanned-readmission-in-patients-with-stroke
#8
Sang Ah Lee, Eun-Cheol Park, Jaeyong Shin, Yeong Jun Ju, Young Choi, Hoo-Yeon Lee
Stroke is frequently associated with readmission; moreover, readmission is regarded as an important indicator of the quality of stroke care. Thus, we investigated factors associated with 30-day readmission in patients with stroke in South Korea. We used claims data from 2013 for stroke (I60-I62) patients (n=44 729) in 94 hospitals and classified unplanned readmission according to the Centers for Medicare and Medicaid guidelines. We used multilevel models to investigate patient (age, gender, type of insurance, admission via emergency room, length of stay, type of stroke, Elixhauser Index Score) and hospital (stroke care quality grade, location of hospital, type of hospital, number of doctors and nurses per 100 beds) factors associated with readmission within 30 days of discharge...
July 23, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30030305/diagnostic-value-of-the-late-night-salivary-cortisol-in-the-diagnosis-of-clinical-and-subclinical-cushing-s-syndrome-results-of-a-single-center-7-year-experience
#9
Nusret Yilmaz, Gokhan Tazegul, Humeyra Bozoglan, Ramazan Sari, Sebahat Ozdem, Hasan Ali Altunbas, Mustafa Kemal Balci
Late-night salivary cortisol (LNSaC) is an easy-to-use test reflecting the free cortisol level in the serum and does not require hospitalization. Controlled studies reported that LNSaC has a high sensitivity and specificity, but have not set a clearly defined cut-off value to be used in the diagnosis of Cushing's syndrome. In this study, we aimed to evaluate the diagnostic performance of LNSaC in patients with clinical Cushing's syndrome (CCS) and subclinical Cushing's syndrome (SCS). The data of 543 patients, whose LNSaC levels were assessed using electrochemiluminescence immunoassay method, were retrospectively evaluated...
July 19, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30006478/regulation-of-indoleamine-2-3-dioxygenase-and-its-role-in-a-porcine-model-of-acute-kidney-allograft-rejection
#10
Youli Wang, Todd D Merchen, Xuexiu Fang, Randi Lassiter, Chak-Sum Ho, Ryan Jajosky, Daniel Kleven, Thomas Thompson, Eslam Mohamed, Miao Yu, Jennifer L Waller, N Stanley Nahman
In kidney transplantation acute allograft rejection is the most common cause of late allograft loss. Changes in indoleamine 2,3 dioxygenase (IDO) activity, which catabolizes the degradation of tryptophan to kynurenine, may predict rejection. However, exogenous IDO is immunosuppressive in rodent kidney transplantation. Thus, the increase in IDO activity observed in acute allograft rejection is insufficient to prevent rejection. To address this question, we assessed the regulation of IDO and its role in acute rejection in a porcine model of kidney transplant...
July 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997148/everolimus-shows-synergistic-antimyeloma-effects-with-bortezomib-via-the-akt-mtor-pathway
#11
Jing Li, Zhaoyun Liu, Yanqi Li, Qian Jing, Honglei Wang, Hui Liu, Jin Chen, Junru Feng, Qing Shao, Rong Fu
Multiple myeloma (MM) is characterized by the proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraproteins (M proteins). Everolimus works similarly to sirolimus as a mammalian target of rapamycin (mTOR) inhibitor. Bortezomib was the first therapeutic proteasome inhibitor to be tested in humans with MM. However, the combination of these two drugs for the treatment of MM has been rarely reported. In this study, we compared the therapeutic effects of everolimus and bortezomib, as well as those of a combination of everolimus and bortezomib, using an in vitro MM cell line model and in vivo xenograft mouse model...
July 11, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997147/effect-of-routine-postdilatation-on-final-coronary-blood-flow-in-primary-percutaneous-coronary-intervention-patients-without-angiographic-stent-expansion-problems
#12
Korhan Soylu, Ali Ekber Ataş, Mustafa Yenerçağ, Murat Akçay, Onur Şeker, Gökhan Aksan, Okan Gülel, Mahmut Şahin
Inadequate expansion of coronary stents is associated with stent thrombosis in early stage and with stent restenosis in later stages. Postdilatation (postD) performed using non-compliant balloons improves stent expansion. However, use of this ballooning strategy in primary percutaneous coronary intervention (PPCI) has not been evaluated adequately. Patients who presented with ST segment elevation myocardial infarction (STEMI) and underwent PPCI were included in the present study. Patients were randomized into two groups as those for whom postD was performed (n=62) and those for whom postD was not performed (n=62)...
July 11, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997146/-schistosoma-mansoni-antigen-sm-p80-prophylactic-efficacy-using-tlr4-agonist-vaccine-adjuvant-glucopyranosyl-lipid-a-alum-in-murine-and-non-human-primate-models
#13
Weidong Zhang, Gul Ahmad, Adebayo J Molehin, Workineh Torben, Loc Le, Eunjee Kim, Samra Lazarus, Arif J Siddiqui, Darrick Carter, Afzal A Siddiqui
Sm-p80, the large subunit of Schistosoma mansoni calpain, is a leading candidate for a schistosomiasis vaccine. The prophylactic and antifecundity efficacy of Sm-p80 has been tested in three animal models (mouse, hamster and baboon) using a multitude of vaccine formulations and approaches. In our continual effort to enhance the vaccine efficacy, in this study, we have utilized the adjuvant, synthetic hexa-acylated lipid A derivative, glucopyranosyl lipid A (GLA) formulated in aluminum (GLA-Alum) with recombinant Sm-p80...
July 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29970479/increased-expression-of-serum-periostin-and-ykl40-in-children-with-severe-asthma-and-asthma-exacerbation
#14
Noussa Ragab El Basha, Hanan Mohsen Osman, Amaal Abdo Abdelaal, Salma Mohamed Saed, Hala Hamdy Shaaban
Children with severe asthma or acute asthma exacerbation may encounter difficulties in performing pulmonary function tests. In this situation, serum biomarkers can play a great role in evaluation of such patients. The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma...
July 3, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29967012/regulatory-bc200-rna-in-peripheral-blood-of-patients-with-invasive-breast-cancer
#15
Anna Iacoangeli, Linda Adzovic, Emily Q Chen, Rabia Latif Cattie, Gerald A Soff, Henri Tiedge
Regulatory brain cytoplasmic 200 RNA (BC200 RNA) is highly expressed in human mammary carcinoma cells. Here, we ask whether BC200 RNA becomes detectable in peripheral blood of patients with invasive breast cancer. Using quantitative reverse-transcription PCR (qRT-PCR) methodology, we observed that BC200 RNA blood levels were significantly elevated, in comparison with healthy subjects, in patients with invasive breast cancer prior to tumorectomy (p=0.001) and in patients with metastatic breast cancer (p=0.003)...
July 2, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29941547/checkpoint-inhibitors-in-head-and-neck-cancer-current-knowledge-and-perspectives
#16
Bachar Samra, Eric Tam, Babak Baseri, Iuliana Shapira
The emergence of immunotherapy has provided significant clinical improvements in the treatment of metastatic solid tumors. Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) has dismal prognosis with median survival ranging between 6and12 months. Our aim is to review the current knowledge on the role of the immune system and immune checkpoint inhibitors in HNSCC. We will focus on the landmark trials that led to the regulatory approvals of pembrolizumab and nivolumab, and discuss a few promising contenders in clinical development and highlight the need to identify better biomarkers other than programmed death-ligand 1 to improve patient selection and help predict response...
June 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29941546/evaluation-of-liver-test-abnormalities-in-a-patient-centered-medical-home-do-liver-test-patterns-matter
#17
Andrew D Schreiner, William P Moran, Jingwen Zhang, Elizabeth B Kirkland, Marc E Heincelman, Samuel O Schumann Iii, Patrick D Mauldin, Don C Rockey
Abnormal liver tests are extremely common in clinical practice, present with varying patterns and degrees of elevation, and can signal liver injury from a variety of causes. Responding to these abnormalities requires complex medical decision-making and merits investigation in primary care. This retrospective study investigates the association of patterns of liver test abnormality with follow-up in primary care. Using administrative data, this study includes patients with abnormal liver tests seen between 2007 and 2016 in a patient-centered medical home...
June 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29891493/the-impact-of-low-dose-glucocorticoids-on-disease-activity-bone-mineral-density-fragility-fractures-and-10-year-probability-of-fractures-in-patients-with-rheumatoid-arthritis
#18
Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Ying-Chou Chen
This study aimed to investigate the effect of low-dose glucocorticoids (LDGs) on disease activity, bone density, and fractures in patients with rheumatoid arthritis (RA). This was an interim analysis of the RA Registry. Demographic data and clinical characteristics, including fracture risk assessment tool, were collected. 25(OH) Vitamin D, bone mineral density (BMD), and intact parathyroid hormone were measured at enrollment. The study group were those who took LDGs (2.5-7.5 mg/day prednisolone or equivalent dose), and the others were included as the control group...
August 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29760160/development-of-a-novel-clinical-staging-model-for-cirrhosis-using-the-nationwide-inpatient-sample
#19
Mona Haj, Mary Hart, Don C Rockey
Scoring systems such as Model for End-stage Liver Disease (MELD) and Child-Pugh are often used by clinicians to determine prognosis in patients with cirrhosis. Since clinical complications are important in determining cirrhosis outcomes, our goal was to use these to develop a novel prognostic staging model. Data from the Nationwide Inpatient Sample (NIS), years 2003-2011, were queried for records of patients over the age of 18 with cirrhosis excluding patients with prior or inpatient liver transplantation. The primary outcome was inpatient mortality with focus on cirrhosis-related complications: non-bleeding esophageal varices, variceal hemorrhage, ascites, hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS)...
August 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29691285/relationships-between-chronic-comorbidities-and-the-atherosclerosis-indicators-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-in-patients-with-type-2-diabetes-mellitus
#20
Chun-Chuan Lee, Ming-Chieh Tsai, Sung-Chen Liu, Chi-Feng Pan
This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis...
August 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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