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Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research

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https://www.readbyqxmd.com/read/30415221/changes-in-calcium-channel-proteins-according-to-magnesium-sulfate-administration-in-placentas-from-pregnancies-with-pre-eclampsia-or-fetal-growth-restriction
#1
Hyun-Hwa Cha, Jae-Ryoung Hwang, Ji Hee Sung, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh
We aimed to evaluate the changes in plasma membrane Ca2+ -ATPase (PMCA) and sarcoendoplasmic reticulum CA2+ -ATPase (SERCA-2) according to the antepartal magnesium sulfate (MgSO4 ) administration in the placentas from pregnancies with pre-eclampsia (PE) or fetal growth restriction (FGR). Pregnant women were classified as follows: (group 1) pregnancies without PE or FGR (n=16), (group 2) pregnancies with PE or FGR but without MgSO4 administration (n=14), and (group 3) pregnancies with PE or FGR and with MgSO4 administration (n=28)...
November 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30385593/significance-of-biglycan-and-osteopontin-as-non-invasive-markers-of-liver-fibrosis-in-patients-with-chronic-hepatitis-b-virus-and-chronic-hepatitis-c-virus
#2
Ali Sobhy, Mohammed Fakhry M, Haitham A Azeem, Ahmed M Ashmawy, Hamed Omar Khalifa
Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN...
October 31, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30368484/clinical-features-of-patients-with-male-breast-cancer-in-shanxi-province-of-china-from-2007-to-2016
#3
Weigang Wang, Xiaoqin Xu, Baoguo Tian, Yan Wang, Lili Du, Ting Sun, Yanchun Shi, Xianwen Zhao, Yali Jia, Yanfeng Xi, Jiexian Jing
This study aims to understand the clinical features, treatment, and prognosis of patients with male breast cancer (MBC) in Shanxi province of China from 2007 to 2016. Data for 77 patients with MBC were collected for analysis. Immunohistochemistry, pathological results, and other data such as demographic characteristics (age, marital status, smoking history, drinking history, and family history of cancer) as well as clinical data were investigated by retrieving information from the patients' medical records...
October 27, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30368483/statins-a-new-approach-to-combat-temozolomide-chemoresistance-in-glioblastoma
#4
Shahla Shojaei, Javad Alizadeh, James Thliveris, Navid Koleini, Elissavet Kardami, Grant M Hatch, Fred Xu, Sabine Hombach-Klonisch, Thomas Klonisch, Saeid Ghavami
Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. The purpose of this proceeding paper is to discuss some of the known anticancer effects of statins, while focusing on GBM therapy that includes adjunct therapy of statins with chemotherapeutic agents...
October 27, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30367011/prevalence-and-risk-factors-of-acquired-long-qt-syndrome-in-hospitalized-patients-with-chronic-kidney-disease
#5
Peng Liu, Dan Han, Xuanzi Sun, Hui Tan, Zhigang Wang, Chao Liu, Yali Zhang, Bailin Li, Chaofeng Sun, Rui Shi, Guoliang Li
Patients with chronic kidney disease (CKD) have a high risk of fatal arrhythmias. The extended severe corrected QT (QTc) interval is a hallmark of ventricular arrhythmias and sudden cardiac death. The objective of this study was to evaluate the prevalence of acquired long QT syndrome (aLQTS) in hospitalized patients with CKD and search for potential risk factors to improve clinical risk stratification in patients with CKD. Information about patients with CKD was retrospectively collected in our hospital between January 2013 and June 2017...
October 26, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30367010/experimental-study-of-the-inhibition-effect-of-cxcl12-cxcr4-in-malignant-pleural-mesothelioma
#6
Jianshuang Li, Tong Li, Shuo Li, Lipeng Xie, Yi-Lin Yang, Qiang Lin, Orli Kadoch, Hui Li, Shengcai Hou, Zhidong Xu
Previous studies have demonstrated that CXCL12/CXCR4 axis is closely related to tumors such as malignant pleural mesothelioma (MPM). This research was conducted in order to detect whether CXCL12/CXCR4 inhibitors could restrain MPM and have a synergistic effect with chemotherapy, also to investigate the relationship of CXCL12/CXCR4 with other gene expressions in MPM. Forty mice were injected MPM cells and randomly divided into four groups: the PBS (control group), AMD3100 (CXCR4-CXCL12 antagonist), pemetrexed and AMD3100 plus pemetrexed...
October 26, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30367009/low-density-lipoprotein-level-on-admission-is-not-associated-with-postintravenous-thrombolysis-intracranial-hemorrhage-in-patients-with-acute-ischemic-stroke
#7
Chien Tai Hong, Wei Ting Chiu, Nai Fang Chi, Le Yan Lai, Chaur Jong Hu, Han Hwa Hu, Lung Chan
Intravenous thrombolysis with the tissue plasminogen activator (tPA) is the gold standard for acute ischemic stroke. However, its application is limited because of the concern of the post-tPA intracranial hemorrhage (ICH). Low low-density lipoprotein (LDL) has been speculated to increase the risk of hemorrhagic transformation after ischemic stroke. However, whether LDL is associated with post-tPA ICH remains controversial. The present study obtained the medical records from Shuang Ho Hospital and retrospectively reviewed for the period between August 2009 and December 2016 to investigate the association between LDL and the risk of post-tPA ICH...
October 26, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30367008/repeat-radiographic-imaging-in-patients-with-long-bone-fractures-transferred-to-a-pediatric-trauma-center
#8
Courtney W Mangus, Bruce L Klein, Marlene Miller, Dylan Stewart, Leticia M Ryan
This study sought to determine the proportion of children with long bone fractures who undergo duplicate radiographic imaging after transfer to a pediatric trauma center (PTC) for further management. The secondary objective was to explore provider rationale and diagnostic yield of repeat X-rays. This was a single-site, retrospective cohort study conducted at a PTC. All patients, aged 0-21 years, who were transferred to the PTC for management of a long bone fracture were included. Electronic medical records were reviewed to determine the proportion of children who had repeat radiographic imaging and the provider rationale for obtaining this...
October 26, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30344140/relationship-between-dental-loss-and-health-outcomes-among-hospitalized-patients-with-and-without-diabetes
#9
Kenneth Izuora, Ammar Yousif, Gayle Allenback, Civon Gewelber, Michael Neubauer
There is mixed evidence regarding the impact of poor dental health on cardiovascular disease and other health outcomes. Our objective was to determine the outcomes associated with poor dental health among hospitalized patients with and without diabetes mellitus (DM) at our institution. We enrolled a consecutive sample of adult patients admitted to an academic medical center. We gathered demographic, health and dental information, reviewed their medical records and then examined their teeth. We analyzed data using SPSS V...
October 21, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30309884/performance-of-the-steatotest-actitest-nashtest-and-fibrotest-in-a-multiethnic-cohort-of-patients-with-type-2-diabetes-mellitus
#10
Fernando Bril, Michael J McPhaul, Michael P Caulfield, Jean-Marie Castille, Thierry Poynard, Consuelo Soldevila-Pico, Virginia C Clark, Roberto J Firpi-Morell, Jinping Lai, Kenneth Cusi
Fibromax is a diagnostic tool composed of the combination of 4 non-invasive biomarker panels for the diagnosis of steatosis (SteatoTest), necrosis and inflammation (ActiTest and NashTest-2) and fibrosis (FibroTest). The purpose of this study was to assess the performance of these biomarker panels in patients with type 2 diabetes mellitus (T2DM). All patients underwent routine labs, a 75 g oral glucose tolerance test, a liver proton magnetic resonance spectroscopy (1 H-MRS) to measure intrahepatic triglyceride content, and a percutaneous liver biopsy to establish the diagnosis of non-alcoholic steatohepatitis (NASH) and to grade and stage the disease in those patients with non-alcoholic fatty liver disease (NAFLD) by 1 H-MRS...
October 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30301867/association-between-fine-particulate-matter-and-oral-cancer-among-taiwanese-men
#11
Yu-Hua Chu, Syuan-Wei Kao, Disline Manli Tantoh, Pei-Chieh Ko, Shou-Jen Lan, Yung-Po Liaw
The aim of this study was to investigate the association between fine particulate matter 2.5 (PM2.5 ) and oral cancer among Taiwanese men. Four linked data sources including the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database were used. Concentrations of sulfur dioxide, carbon monoxide, ozone, NOx (nitrogen monoxide and nitrogen dioxide), coarse particulate matter (PM10-2.5 ) and PM2.5 in 2009 were assessed in quartiles...
October 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30297390/prostate-cancer-aggressiveness-and-age-impact-of-p53-bcl-2-and-microvessel-density
#12
Lisa Calvocoressi, Edward Uchio, John Ko, Krishnan Radhakrishnan, Mihaela Aslan, John Concato
Older men are more likely to have advanced prostate cancer at time of their diagnosis, but whether prostate tumors are inherently (biologically) more aggressive with advancing age is uncertain. To address this gap in knowledge, we analyzed data from veterans (n=971) diagnosed with prostate cancer during 1991-1995. Factors included age, detection of prostate cancer by screening, prostate-specific antigen (PSA) level, anatomic stage, and Gleason score. Information on molecular markers obtained from immunohistochemical staining of prostate tissue, included B cell lymphoma-2 (bcl-2), p53, and microvessel density (MVD), each having a previously documented association with disease progression and increased risk of prostate cancer death...
October 7, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30287476/association-between-socioeconomic-status-and-risk-of-hospitalization-due-to-child-maltreatment-in-the-usa
#13
Sehyr Imran, Chad Cross, Samrat U Das
Child maltreatment remains a significant problem in the USA. There is a dearth of literature examining the association of socioeconomic status (SES) and incidence of child maltreatment among hospitalized children across the entire USA. Our aim was to study the association between SES and incidence and mortality from child maltreatment among hospitalized children in the USA. We used 2013-2014 data from the Nationwide Inpatient Sample, a discharge database representative of all hospitals in the USA. International Classification of Diseases-9 codes for general child maltreatment were used to identify patients discharged with a primary diagnosis of child maltreatment...
October 3, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30287475/plasma-haptoglobin-level-can-augment-nt-probnp-to-predict-poor-outcome-in-patients-with-severe-acute-decompensated-heart-failure
#14
Dai-Yin Lu, Chih-Pei Lin, Cheng-Hsueh Wu, Tsai-Mu Cheng, Ju-Pin Pan
To evaluate the use of plasma haptoglobin (Hp) levels and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in predicting survival in patients with severe acute decompensated heart failure (AHF). Management of AHF is challenging. Identifying markers associated with patient prognosis in this disease is clinically important. In this prospective observational study, plasma Hp and NT-proBNP levels were measured. Receiver operating characteristic (ROC) curves were used to identify cut-offs of Hp and NT-proBNP with the greatest specificity and sensitivity for predicting overall survival and cardiovascular-related survival...
October 3, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30275006/risk-of-psychiatric-disorders-in-overactive-bladder-syndrome-a-nationwide-cohort-study-in-taiwan
#15
Nian-Sheng Tzeng, Hsin-An Chang, Chi-Hsiang Chung, Yu-Chen Kao, Hui-Wen Yeh, Chin-Bin Yeh, Wei-Shan Chiang, San-Yuan Huang, Ru-Band Lu, Wu-Chien Chien
Population-based cohort study investigating the risk of depression and other psychiatric disorders for patients with overactive bladder (OAB) syndrome is unavailable. This study investigated the subsequent risk of psychiatric disorders among patients with OAB in an Asian population. Using data from the National Health Insurance Research Database of Taiwan, we established a cohort with 811 patients in an exposed group with OAB between January 1, 2000 and December 31, 2000, and a non-exposed group, without OAB, of 2433 patients without OAB matched by age and year of diagnosis...
October 1, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30258027/nomogram-incorporating-clinicopathological-parameters-to-predict-the-survival-of-patients-with-mantle-cell-lymphoma
#16
Yuandong Zhu, Wenxian Xu, Xiao Zheng, Zhuojun Zheng
This study intended to present a practicable prognostic nomogram for patients with mantle cell lymphoma (MCL). The clinical data of 281 patients were reviewed. A nomogram that could predict overall survival (OS) was constructed based on the Cox proportional hazard model. To compare the capacity of the nomogram with the International Prognostic Index (IPI) and MCL International Prognostic Index (MIPI) scoring systems, we used the concordance index (C-index) to validate the veracity and the calibration curve...
September 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30158166/high-power-doppler-ultrasound-score-is-associated-with-the-risk-of-triangular-fibrocartilage-complex-tfcc-tears-in-severe-rheumatoid-arthritis
#17
Jen-Hung Chen, Kuo-Chin Huang, Chung-Cheng Huang, Han-Ming Lai, Wen-Yi Chou, Ying-Chou Chen
In the distal radioulnar joint, the triangular fibrocartilage complex (TFCC) is an important stabilizer and are frequently found in patients with rheumatoid arthritis (RA) with wrist pain. This study was designed to predict TFCC tears using high-resolution ultrasound in severe RA. We retrospectively reviewed patients with severe RA. MRI and ultrasound were performed at baseline and after 1 year of follow-up. TFCC tears were recorded. The predictive factors for TFCC tears were analyzed by logistic regression...
August 29, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30127099/development-and-validation-of-nomogram-based-on-siri-for-predicting-the-clinical-outcome-in-patients-with-nasopharyngeal-carcinomas
#18
Yuan Chen, Wenjie Jiang, Dan Xi, Jun Chen, Guoping Xu, Wenming Yin, Junjun Chen, Wendong Gu
The Systemic Inflammation Response Index (SIRI), based on peripheral lymphocyte, neutrophil, and monocyte counts, was recently investigated as a prognostic marker for several tumors. However, use of the SIRI has not been reported for nasopharyngeal carcinoma (NPC). We evaluated the prognostic value of the SIRI in primary and validation cohorts. We also established an effective prognostic nomogram for NPC based on clinicopathological parameters and the SIRI. The predictive accuracy and discriminative ability of the nomogram were determined using the concordance index (C-index) and a calibration curve and were compared with tumor-node-metastasis classifications...
August 20, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30127098/new-and-emerging-therapies-for-acute-myeloid-leukaemia
#19
Julian R Davis, David J Benjamin, Brian A Jonas
The treatment of acute myeloid leukemia (AML) has remained relatively unchanged for the past 3-4 decades with generally poor outcomes, especially in elderly populations unfit for intensive therapy. Recent advancements, however, have identified several cytogenetic and molecular markers that have not only improved prognostication but have also led to the development of several new targeted therapies for specific subpopulations. In 2017, the US Food and Drug Administration approved four new treatments with indications for fms like tyrosine kinase 3 (FLT3)-mutated AML (midostaurin), newly diagnosed or relapsed/refractory CD33+AML (gemtuzumab ozogamicin), newly diagnosed therapy-related AML or AML with myelodysplasia-related changes (CPX-351) and relapsed/refractory AML with an isocitrate dehydrogenase (IDH)2 mutation (enasidenib)...
August 19, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30254037/correction-intramyocardial-block-in-patients-with-atrioventricular-block
#20
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October 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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