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Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research

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https://www.readbyqxmd.com/read/28073942/emergency-department-visits-related-to-functional-abdominal-pain-in-the-pediatric-age-group
#1
Chaitanya Pant, Abhishek Deshpande, Thomas J Sferra, Mojtaba Olyaee
To analyze visits to and admissions from the emergency department (ED) in children with a primary diagnosis of functional abdominal pain (FAP). This was a cross-sectional study using data from the Nationwide Emergency Department Sample (HCUP-NEDS 2008-2012). FAP-related ED visits were identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes. The most frequent secondary diagnoses associated with FAP-related ED visits were also extracted. In 2012, a total of 796,665 children presented to the ED with a primary diagnosis of FAP...
January 10, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28069629/randomized-pragmatic-trial-of-nasogastric-tube-placement-in-patients-with-upper-gastrointestinal-tract-bleeding
#2
Don C Rockey, Chul Ahn, Silvio W de Melo
: The value of nasogastric (NG) tube placement in patients with upper gastrointestinal tract bleeding (UGIB) is unclear. We therefore aimed to determine the usefulness of NG tube placement in patients with UGIB. The study was a single-blind, randomized, prospective, non-inferiority study comparing NG placement (with aspiration and lavage) to no NG placement (control). The primary outcome was the probability that physicians could predict the presence of a high-risk lesion (ie, requiring endoscopic therapy)...
January 9, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28057714/elevated-il-37-il-18-and-il-18bp-serum-concentrations-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#3
Wang Liuqing, Xia Liping, Shen Hui, Lu Jing
The objectives of this study were to examine the serum levels of interleukin (IL)-37 and its clinical association in patients with primary Sjögren's syndrome (pSS) and to investigate whether or not IL-37 participates in the regulation of the pathogenesis of pSS. ELISA was used to analyse the serum levels of IL-37, total IL-18 and IL-18 binding protein (IL-18BP). The level of free IL-18 was calculated based on the mass action law. The correlations between the IL-37 serum levels with the laboratory values and the total IL-18 and IL-18BP serum levels were analyzed by a Spearman's correlation test...
January 5, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27993947/shared-decision-making-following-disclosure-of-coronary-heart-disease-genetic-risk-results-from-a-randomized-clinical-trial
#4
Hayan Jouni, Raad A Haddad, Tariq S Marroush, Sherry-Ann Brown, Teresa M Kruisselbrink, Erin E Austin, Khader Shameer, Emma M Behnken, Rajeev Chaudhry, Victor M Montori, Iftikhar J Kullo
: Whether disclosure of genetic risk for coronary heart disease (CHD) influences shared decision-making (SDM) regarding use of statins to reduce CHD risk is unknown. We randomized 207 patients, age 45-65 years, at intermediate CHD risk, and not on statins, to receive the 10-year risk of CHD based on conventional risk factors alone (n=103) or in combination with a genetic risk score (n=104). A genetic counselor disclosed this information followed by a physician visit for SDM regarding statin therapy...
December 19, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27980005/characterization-of-pabpn1-expansion-mutations-in-a-large-cohort-of-mexican-patients-with-oculopharyngeal-muscular-dystrophy-opmd
#5
Marisa Cruz-Aguilar, Caroline Guerrero-de Ferran, Jose Luis Tovilla-Canales, Angel Nava-Castañeda, Juan C Zenteno
Oculopharyngeal muscular dystrophy (OPMD) is an autosomal-dominant, adult-onset disorder defined by blepharoptosis, dysphagia, and proximal muscle weakness. OPMD arises from heterozygous expansions of a trinucleotide (GCN) tract situated at the 5' region of the polyadenylate RNA binding protein 1 (PABPN1) gene. The frequency of a particular (GCN) expansion in a given population of patients with OPMD is largely influenced by the occurrence of founder mutations. Analysis of large groups of patients with OPMD from different ethnic origins will help to estimate the relative contribution of each expanded allele to the disease...
December 15, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27965361/effect-of-preceding-medications-on-resuscitation-outcome-of-out-of-hospital-cardiac-arrest
#6
Shih-Wen Hung, Chien-Ming Chu, Chih-Feng Su, Li-Ming Tseng, Tzong-Luen Wang
As evidence regarding the impact of preceding medications on resuscitation outcomes has been inconsistent, this study aimed to analyze the association between preceding medications and resuscitation outcomes in patients experiencing out-of-hospital cardiac arrest (OHCA). This retrospective study included patients with OHCA presenting to a tertiary care hospital by emergency medical service (EMS) between January 2006 and June 2011. Using the Utstein template, data were collected from EMS and hospital medical records for prehospital care, in-hospital care, and medications which were taken continuously for at least 2 weeks preceding OHCA...
December 13, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27940551/management-of-alcohol-misuse-in-patients-with-liver-diseases
#7
Jennifer L Peng, Milan Prakash Patel, Breann McGee, Tiebing Liang, Kristina Chandler, Sucharat Tayarachakul, Sean O'Connor, Suthat Liangpunsakul
Excessive alcohol use not only causes alcoholic liver disease (ALD) but also increases the risk of liver-related mortality in patients who already have other chronic liver diseases. Screening for alcohol misuse or alcohol use disorder (AUD) among patients with underlying liver disease is essential. This clinical review covers what is known about ALD, the impact of alcohol in patients with underlying liver diseases, current management of alcohol misuse and AUD, and the management of alcohol misuse and AUD specifically in patients with liver diseases...
December 9, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27940550/cox-2-dependent-and-independent-effects-of-cox-2-inhibitors-and-nsaids-on-proatherogenic-changes-in-human-monocytes-macrophages
#8
Iryna Voloshyna, Lora J Kasselman, Steven E Carsons, Michael J Littlefield, Irving H Gomolin, Joshua De Leon, Allison B Reiss
It is the second decade of controversy regarding the cardiovascular effects of cyclo-oxygenase-2 (COX-2) inhibitors. At this time, celecoxib is the only available COX-2-specific inhibitor for treatment of pain and inflammation. Therefore, the present study was designed primarily to determine the impact of celecoxib on cholesterol handling (uptake via scavenger receptors and efflux from the cells) and foam cell formation in human THP-1 macrophages, followed by comparison to rofecoxib and other non-steroidal anti-inflammatory drugs (NSAIDs)...
December 9, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27864324/colorectal-cancer-is-a-leading-cause-of-cancer-incidence-and-mortality-among-adults-younger-than-50%C3%A2-years-in-the-usa-a-seer-based-analysis-with-comparison-to-other-young-onset-cancers
#9
Abhishek Bhandari, Melissa Woodhouse, Samir Gupta
Colorectal cancer (CRC) incidence and mortality are rising among young adults. Our aim was to contrast the relative incidence and mortality of CRC to other common cancers among young adults in the USA. We used Surveillance, Epidemiology, and End Results registry data to compare cancer site-specific and age-specific mortality and incident rates for adults younger than age 50. We summarized extracted data, both overall, and stratified by sex. We found CRC was the third leading cause of cancer death among adults younger than age 50, after breast and lung cancer (1...
November 18, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27807146/scientific-retreats-with-speed-dating-networking-to-stimulate-new-interdisciplinary-translational-research-collaborations-and-team-science
#10
Damayanthi Ranwala, Anthony J Alberg, Kathleen T Brady, Jihad S Obeid, Randal Davis, Perry V Halushka
To stimulate the formation of new interdisciplinary translational research teams and innovative pilot projects, the South Carolina Clinical and Translational Research (SCTR) Institute (South Carolina Clinical and Translational Science Award, CTSA) initiated biannual scientific retreats with 'speed dating' networking sessions. Retreat themes were prioritized based on the following criteria; cross-cutting topic, unmet medical need, generation of novel technologies and methodologies. Each retreat begins with an external keynote speaker followed by a series of brief research presentations by local researchers focused on the retreat theme, articulating potential areas for new collaborations...
November 2, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27803113/histopathological-evaluation-and-expression-of-the-pluripotent-mesenchymal-stem-cell-like-markers-cd105-and-cd44-in-the-synovial-membrane-of-patients-with-primary-versus-secondary-hip-osteoarthritis
#11
Sabin Gligore Turdean, Ioan Jung, Simona Gurzu, Ancuta Zazgyva, Annamaria Fetyko, Ciprian Oliviu Roman, Mihai Turcu, Tudor Sorin Pop
To present the morphological changes of classic primary versus rapidly progressive and secondary hip osteoarthritis (HO) and to examine the expression of two pluripotent mesenchymal stem cell-like markers in the synovial membrane. A prospective observational study was conducted in 57 consecutive cases of radiologically confirmed HO in which total hip arthroplasty was performed. Based on the radiological and clinicopathological features, the cases were divided into three categories: classic primary HO (group A; n=16), rapidly destructive HO (group B; n=24), and HO secondary to avascular osteonecrosis of the femoral head (group C; n=17)...
November 1, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27793974/nanosims-imaging-an-approach-for-visualizing-and-quantifying-lipids-in-cells-and-tissues
#12
Cuiwen He, Loren G Fong, Stephen G Young, Haibo Jiang
Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.
October 28, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27793973/examining-the-validity-of-the-acs-nsqip-risk-calculator-in-plastic-surgery-lack-of-input-specificity-outcome-variability-and-imprecise-risk-calculations
#13
Cassandra Johnson, Insiyah Campwala, Subhas Gupta
American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) created the Surgical Risk Calculator, to allow physicians to offer patients a risk-adjusted 30-day surgical outcome prediction. This tool has not yet been validated in plastic surgery. A retrospective analysis of all plastic surgery-specific complications from a quality assurance database from September 2013 through July 2015 was performed. Patient preoperative risk factors were entered into the ACS Surgical Risk Calculator, and predicted outcomes were compared with actual morbidities...
October 28, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27789660/does-aspirin-use-reduce-the-risk-for-cancer
#14
Usman Iqbal, Hsuan-Chia Yang, Wen-Shan Jian, Yun Yen, Yu-Chuan Jack Li
Recently, studies have reported that aspirin has chemopreventive properties. In this study, we used the Taiwan NHI database, which covers a population of 23 million (99.99%) Taiwanese from 2001 to 2011. This was a case-control study which identified 601,733 patients using ICD-9-CM codes who were diagnosed with cancer. Each case with 4 eligible controls was matched for age, sex, and index date and adjusted for confounding factors. The observed overall cancer risk (adjusted OR (AOR), 0.95; 95% CI 0.94 to 0.96) reduced with aspirin use, specifically, colorectal (AOR, 0...
October 27, 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28011923/author-index
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27683729/effects-of-curcumin-in-experimental-diabetic-nephropathy
#16
Sharma S Prabhakar
Diabetic nephropathy (DN) is currently well established as the most common cause of end-stage renal disease in most parts of the world. Notwithstanding the expanding basic and clinical research in this field, the pathogenesis remains far from clear and hence the treatment of DN remains suboptimal. There is a critical need for the development of newer therapeutic strategies including alternative and complementary therapies. One of the natural products that was extensively studied in cancer and other chronic disease states such as diabetes is curcumin, an active ingredient in turmeric, a spice extensively used in India...
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27664271/egfr-gene-copy-number-as-a-predictive-biomarker-for-patients-with-non-small-cell-lung-cancer-receiving-tyrosine-kinase-inhibitor-treatment-a-systematic-review-and-meta-analysis
#17
Xin Zhang, Yiwen Zhang, Hailing Tang, Jianxing He
Epidermal growth factor receptor (EGFR) gene copy number has been proposed as a candidate biomarker for predicting treatment response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with advanced non-small-cell lung cancer (NSCLC). MEDLINE, PubMed, Cochrane, and Google Scholar databases were searched until October 21, 2015 using the following search terms: lung neoplasms/lung cancer/non-small cell lung cancer/NSCLC, EGFR, gene amplification, copy number, erlotinib, gefitinib, tyrosine-kinase inhibitor/TKI, predictor...
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27634643/executive-functioning-in-children-with-congenital-adrenal-hyperplasia
#18
A Monica Agoston, Maria Teresa Gonzalez-Bolanos, Margaret Semrud-Clikeman, Nancy Vanderburg, Kyriakie Sarafoglou
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is a disorder characterized by impaired cortisol synthesis leading to excessive production of adrenal androgens. Prenatal and postnatal exposure to excess androgens may increase neural vulnerability to insult and affect cognitive functions, particularly dopamine-dependent neural circuits responsible for executive functioning (EF). Our study aimed to investigate relationship between more pronounced androgen exposure and EF-related behaviors in children with CAH, as well as sex differences in these associations...
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27634642/association-between-serum-cotinine-level-and-prevalence-of-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-from-the-third-national-health-and-nutrition-examination-survey
#19
Huafeng Shen, Jennifer L Peng, Sucharat Tayarachakul, Suthat Liangpunsakul
The data on the effect of smoking on non-alcoholic fatty liver disease (NAFLD) has been controversial. The aim of this study was to investigate if an association exists between serum cotinine level (a tobacco biomarker) and NAFLD prevalence in the general US population. We conducted a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III). We included 11,003 adults aged 20-74 years who underwent ultrasonography. Of those, 4036 were identified as having NAFLD and 6967 were recognized as controls...
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27625418/evaluation-of-the-performance-of-c-diff-quik-chek-complete-and-its-usefulness-in-a-hospital-setting-with-a-high-prevalence-of-clostridium-difficile-infection
#20
Hae-Sun Chung, Miae Lee
Rapid and accurate diagnosis of Clostridium difficile infection (CDI) is crucial for patient care, infection control, and efficient surveillance. We evaluated C. DIFF QUIK CHEK COMPLETE (QCC; TechLab), which detects glutamate dehydrogenase (GDH) antigen (QCC-Ag) and toxin A/B (QCC-Tox) simultaneously, and compared it to the laboratory diagnostics for CDI currently in use in a tertiary hospital setting with a high prevalence of CDI. QCC, RIDASCREEN C. difficile toxin A/B assay (Toxin EIA; R-Biopharm AG), chromID C...
January 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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