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Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research

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https://www.readbyqxmd.com/read/30006478/regulation-of-indoleamine-2-3-dioxygenase-and-its-role-in-a-porcine-model-of-acute-kidney-allograft-rejection
#1
Youli Wang, Todd D Merchen, Xuexiu Fang, Randi Lassiter, Chak-Sum Ho, Ryan Jajosky, Daniel Kleven, Thomas Thompson, Eslam Mohamed, Miao Yu, Jennifer L Waller, N Stanley Nahman
In kidney transplantation acute allograft rejection is the most common cause of late allograft loss. Changes in indoleamine 2,3 dioxygenase (IDO) activity, which catabolizes the degradation of tryptophan to kynurenine, may predict rejection. However, exogenous IDO is immunosuppressive in rodent kidney transplantation. Thus, the increase in IDO activity observed in acute allograft rejection is insufficient to prevent rejection. To address this question, we assessed the regulation of IDO and its role in acute rejection in a porcine model of kidney transplant...
July 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997148/everolimus-shows-synergistic-antimyeloma-effects-with-bortezomib-via-the-akt-mtor-pathway
#2
Jing Li, Zhaoyun Liu, Yanqi Li, Qian Jing, Honglei Wang, Hui Liu, Jin Chen, Junru Feng, Qing Shao, Rong Fu
Multiple myeloma (MM) is characterized by the proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraproteins (M proteins). Everolimus works similarly to sirolimus as a mammalian target of rapamycin (mTOR) inhibitor. Bortezomib was the first therapeutic proteasome inhibitor to be tested in humans with MM. However, the combination of these two drugs for the treatment of MM has been rarely reported. In this study, we compared the therapeutic effects of everolimus and bortezomib, as well as those of a combination of everolimus and bortezomib, using an in vitro MM cell line model and in vivo xenograft mouse model...
July 11, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997147/effect-of-routine-postdilatation-on-final-coronary-blood-flow-in-primary-percutaneous-coronary-intervention-patients-without-angiographic-stent-expansion-problems
#3
Korhan Soylu, Ali Ekber Ataş, Mustafa Yenerçağ, Murat Akçay, Onur Şeker, Gökhan Aksan, Okan Gülel, Mahmut Şahin
Inadequate expansion of coronary stents is associated with stent thrombosis in early stage and with stent restenosis in later stages. Postdilatation (postD) performed using non-compliant balloons improves stent expansion. However, use of this ballooning strategy in primary percutaneous coronary intervention (PPCI) has not been evaluated adequately. Patients who presented with ST segment elevation myocardial infarction (STEMI) and underwent PPCI were included in the present study. Patients were randomized into two groups as those for whom postD was performed (n=62) and those for whom postD was not performed (n=62)...
July 11, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29997146/-schistosoma-mansoni-antigen-sm-p80-prophylactic-efficacy-using-tlr4-agonist-vaccine-adjuvant-glucopyranosyl-lipid-a-alum-in-murine-and-non-human-primate-models
#4
Weidong Zhang, Gul Ahmad, Adebayo J Molehin, Workineh Torben, Loc Le, Eunjee Kim, Samra Lazarus, Arif J Siddiqui, Darrick Carter, Afzal A Siddiqui
Sm-p80, the large subunit of Schistosoma mansoni calpain, is a leading candidate for a schistosomiasis vaccine. The prophylactic and antifecundity efficacy of Sm-p80 has been tested in three animal models (mouse, hamster and baboon) using a multitude of vaccine formulations and approaches. In our continual effort to enhance the vaccine efficacy, in this study, we have utilized the adjuvant, synthetic hexa-acylated lipid A derivative, glucopyranosyl lipid A (GLA) formulated in aluminum (GLA-Alum) with recombinant Sm-p80...
July 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29970479/increased-expression-of-serum-periostin-and-ykl40-in-children-with-severe-asthma-and-asthma-exacerbation
#5
Noussa Ragab El Basha, Hanan Mohsen Osman, Amaal Abdo Abdelaal, Salma Mohamed Saed, Hala Hamdy Shaaban
Children with severe asthma or acute asthma exacerbation may encounter difficulties in performing pulmonary function tests. In this situation, serum biomarkers can play a great role in evaluation of such patients. The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma...
July 3, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29967012/regulatory-bc200-rna-in-peripheral-blood-of-patients-with-invasive-breast-cancer
#6
Anna Iacoangeli, Linda Adzovic, Emily Q Chen, Rabia Latif Cattie, Gerald A Soff, Henri Tiedge
Regulatory brain cytoplasmic 200 RNA (BC200 RNA) is highly expressed in human mammary carcinoma cells. Here, we ask whether BC200 RNA becomes detectable in peripheral blood of patients with invasive breast cancer. Using quantitative reverse-transcription PCR (qRT-PCR) methodology, we observed that BC200 RNA blood levels were significantly elevated, in comparison with healthy subjects, in patients with invasive breast cancer prior to tumorectomy (p=0.001) and in patients with metastatic breast cancer (p=0.003)...
July 2, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29941547/checkpoint-inhibitors-in-head-and-neck-cancer-current-knowledge-and-perspectives
#7
Bachar Samra, Eric Tam, Babak Baseri, Iuliana Shapira
The emergence of immunotherapy has provided significant clinical improvements in the treatment of metastatic solid tumors. Recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) has dismal prognosis with median survival ranging between 6and12 months. Our aim is to review the current knowledge on the role of the immune system and immune checkpoint inhibitors in HNSCC. We will focus on the landmark trials that led to the regulatory approvals of pembrolizumab and nivolumab, and discuss a few promising contenders in clinical development and highlight the need to identify better biomarkers other than programmed death-ligand 1 to improve patient selection and help predict response...
June 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29941546/evaluation-of-liver-test-abnormalities-in-a-patient-centered-medical-home-do-liver-test-patterns-matter
#8
Andrew D Schreiner, William P Moran, Jingwen Zhang, Elizabeth B Kirkland, Marc E Heincelman, Samuel O Schumann Iii, Patrick D Mauldin, Don C Rockey
Abnormal liver tests are extremely common in clinical practice, present with varying patterns and degrees of elevation, and can signal liver injury from a variety of causes. Responding to these abnormalities requires complex medical decision-making and merits investigation in primary care. This retrospective study investigates the association of patterns of liver test abnormality with follow-up in primary care. Using administrative data, this study includes patients with abnormal liver tests seen between 2007 and 2016 in a patient-centered medical home...
June 25, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29903897/children-with-allergic-diseases-have-an-increased-subsequent-risk-of-migraine-upon-reaching-school-age
#9
Chang-Ching Wei, Cheng-Li Lin, Te-Chun Shen, An-Chyi Chen
The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7-18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis...
June 14, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29895584/survival-in-b-cell-primary-ocular-lymphoma-1997-2014-a-population-based-study
#10
Deliang L Liu, Zhuojun J Zheng
This study sought to explore the prognostic factors in a large retrospective cohort of patients with B-cell primary ocular lymphoma (POL) from the Surveillance, Epidemiology, and End Results database. There were 2778 patients with B-cell POL whose complete clinical information was listed in the Surveillance, Epidemiology, and End Results database between 1997 and 2014. The epidemiology, therapeutic measures, and clinical characteristics were listed as descriptive statistics. Survival analysis was conducted by univariate and multivariable Cox regression models...
June 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29891493/the-impact-of-low-dose-glucocorticoids-on-disease-activity-bone-mineral-density-fragility-fractures-and-10-year-probability-of-fractures-in-patients-with-rheumatoid-arthritis
#11
Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Ying-Chou Chen
This study aimed to investigate the effect of low-dose glucocorticoids (LDGs) on disease activity, bone density, and fractures in patients with rheumatoid arthritis (RA). This was an interim analysis of the RA Registry. Demographic data and clinical characteristics, including fracture risk assessment tool, were collected. 25(OH) Vitamin D, bone mineral density (BMD), and intact parathyroid hormone were measured at enrollment. The study group were those who took LDGs (2.5-7.5 mg/day prednisolone or equivalent dose), and the others were included as the control group...
June 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29884660/risk-of-dementia-after-charcoal-burning-suicide-attempts-a-nationwide-cohort-study-in-taiwan
#12
Shan-Yueh Chang, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Yu-Ching Chou, Chung-Kan Peng, Chih-Hao Shen, Nian-Sheng Tzeng
This study aimed to investigate the association between charcoal-burning suicide attempts and the risk of developing dementia. A nationwide, matched cohort, population-based study enrolled a total of 4103 patients with newly diagnosed charcoal-burning suicide attempts, between 2000 and 2010, which were selected from the National Health Insurance Research Database of Taiwan, along with 12,309 controls matched for sex and age. After adjusting for confounding factors, Fine and Gray's competing risk analysis was used to compare the risk of developing dementia during the 10-year follow-up period...
June 8, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29880535/pilot-study-on-the-occurrence-of-multiple-cancers-following-cancer-related-therapy-at-the-university-of-florida-jacksonville-2011-2016
#13
Karan Seegobin, Estela Staggs, Robina Khawaja, Satish Maharaj, Shiva Gautam, Carmen Smotherman, Fauzia Rana
New primary cancers can occur in patients with a previous cancer. Among the risk factors, therapies such as chemotherapy, radiotherapy, and hormonal therapy have been associated with the development of neoplasms. Second cancers most commonly develop 5-10 years after the initial tumor. We observe the implications of cancer-related therapy in the development of a new tumor. We looked at 602 patients who had their first cancer diagnosed in 2011 and calculated the number of different primary cancers between 2011 and 2016 for each patient...
June 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29880534/recombinant-tissue-plasminogen-activator-treatment-of-pulmonary-embolism-also-improves-deep-venous-thrombosis
#14
Mukremin Er
Anticoagulants are the standard form of treatment used in deep vein thrombosis (DVT). Thrombolytic therapy is another method to treat thromboembolism by using intravenous administration of streptokinase, urokinase and recombinant tissue plasminogen activator (r-tPA). We have investigated the effect of r-tPA, a systemic thrombolytic used for the treatment of pulmonary emboli, on DVT in the same patients. 130 patients who were diagnosed with both pulmonary embolism and DVT were included in this study. Lower extremity Doppler ultrasonography (DUS) was conducted on all of the patients upon admission and then on the 6th month...
June 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29760160/development-of-a-novel-clinical-staging-model-for-cirrhosis-using-the-nationwide-inpatient-sample
#15
Mona Haj, Mary Hart, Don C Rockey
Scoring systems such as Model for End-stage Liver Disease (MELD) and Child-Pugh are often used by clinicians to determine prognosis in patients with cirrhosis. Since clinical complications are important in determining cirrhosis outcomes, our goal was to use these to develop a novel prognostic staging model. Data from the Nationwide Inpatient Sample (NIS), years 2003-2011, were queried for records of patients over the age of 18 with cirrhosis excluding patients with prior or inpatient liver transplantation. The primary outcome was inpatient mortality with focus on cirrhosis-related complications: non-bleeding esophageal varices, variceal hemorrhage, ascites, hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS)...
May 14, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29691285/relationships-between-chronic-comorbidities-and-the-atherosclerosis-indicators-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-in-patients-with-type-2-diabetes-mellitus
#16
Chun-Chuan Lee, Ming-Chieh Tsai, Sung-Chen Liu, Chi-Feng Pan
This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis...
April 24, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29680828/viral-pneumonia-etiologies-and-treatment
#17
Dima Dandachi, Maria C Rodriguez-Barradas
Viral pathogens are increasingly recognized as a cause of pneumonia, in immunocompetent patients and more commonly among immunocompromised. Viral pneumonia in adults could present as community-acquired pneumonia (CAP), ranging from mild disease to severe disease requiring hospital admission and mechanical ventilation. Moreover, the role of viruses in hospital-acquired pneumonia and ventilator-associated pneumonia as causative agents or as co-pathogens and the effect of virus detection on clinical outcome are being investigated...
April 20, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29632031/analysis-of-circulating-tumor-cells-in-patients-with-hepatocellular-carcinoma-recurrence-following-liver-transplantation
#18
Shaoping Wang, Yujian Zheng, Jun Liu, Feng Huo, Jie Zhou
Although studies have shown that detection of peripheral circulating tumor cells (CTCs) is an important tool for monitoring prognosis and therapeutic response in patients with cancer, few studies have analyzed their role in patients with hepatocellular carcinoma (HCC) following liver transplantation (LTx). The present study examined whether CTC levels were associated with HCC recurrence in patients with HCC after LTx. This prospective study included 47 patients who received LTx between October 2014 and May 2016 and who underwent analysis for peripheral CTCs at least twice using the CanPatrol system...
June 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29622757/significance-of-neurexin-and-neuroligin-polymorphisms-in-regulating-risk-of-hirschsprung-s-disease
#19
Yanhong Li, Hui Liu, Yubin Dong
By performing a basic case-control study among a Chinese population, the aims of this study were to explore if single nucleotide polymorphisms (SNPs) within neurexin and neuroligin were associated with susceptibility to Hirschsprung's disease (HD). Eleven SNPs within neurexin and neuroligin were selected in this basic case-control study, and this study recruited 210 children with HD and 187 healthy children. The t-test and Χ2 test were used to find the difference between case and control in their clinical variables...
June 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29622756/hsv-infection-is-associated-with-gestational-hypertension-results-from-the-us-national-inpatient-sample
#20
Lifeng Shi, Yan Wu
The purpose of this study was to determine if there is an association between maternal herpes simplex virus (HSV) infection and pre-eclampsia/eclampsia or gestational hypertension. The US Nationwide Inpatient Sample database was searched for women aged 15-44 years who delivered in a hospital between 2005 and 2014. The patients were categorized into those with and without HSV and pre-eclampsia/eclampsia and gestational hypertension were compared between the groups. The analytic sample size (n=8 264 076) was equivalent to a population-based sample size of 40 653 030 patients...
June 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
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