journal
https://read.qxmd.com/read/38423194/alteration-of-gut-microbiota-in-post-stroke-depression-patients-with-helicobacter-pylori-infection
#21
JOURNAL ARTICLE
Mei Sun, Han Chen, Siyu Dong, Guoxin Zhang, Xiaoying Zhou, Hong Cheng
BACKGROUND: Several studies have identified an association between the gut microbiome and post-stroke depression(PSD), and Helicobacter pylori(H. pylori) infection cause significant alterations in the composition of the gastrointestinal microbiome. However, evidence regarding the role of the H. pylori infection in promoting PSD is still lacking. Here, we conducted a retrospective study to explore risk factors associated with PSD. METHODS: Patients with cerebral infarction were consecutively enrolled from December 2021 to October 2022...
February 28, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38423193/blood-and-cerebellar-abundance-of-atxn3-splice-variants-in-spinocerebellar-ataxia-type-3-machado-joseph-disease
#22
JOURNAL ARTICLE
Mafalda Raposo, Jeannette Hübener-Schmid, Rebecca Tagett, Ana F Ferreira, Ana Rosa Vieira Melo, João Vasconcelos, Paula Pires, Teresa Kay, Hector Garcia-Moreno, Paola Giunti, Magda M Santana, Luis Pereira de Almeida, Jon Infante, Bart P van de Warrenburg, Jeroen J de Vries, Jennifer Faber, Thomas Klockgether, Nicolas Casadei, Jakob Admard, Ludger Schöls, Olaf Riess, Maria do Carmo Costa, Manuela Lima
Spinocerebellar ataxia type 3 (SCA3)/Machado-Joseph disease (MJD) is a heritable proteinopathy disorder, whose causative gene, ATXN3, undergoes alternative splicing. Ataxin-3 protein isoforms differ in their toxicity, suggesting that certain ATXN3 splice variants may be crucial in driving the selective toxicity in SCA3. Using RNA-seq datasets we identified and determined the abundance of annotated ATXN3 transcripts in blood (n = 60) and cerebellum (n = 12) of SCA3 subjects and controls...
February 27, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38423192/the-free-plasma-amyloid-a%C3%AE-1-42-a%C3%AE-1-40-ratio-predicts-conversion-to-dementia-for-subjects-with-mild-cognitive-impairment-with-performance-equivalent-to-that-of-the-total-plasma-a%C3%AE-1-42-a%C3%AE-1-40-ratio-the-baltazar-study
#23
JOURNAL ARTICLE
S Schraen-Maschke, A Duhamel, J S Vidal, N Ramdane, L Vaudran, C Dussart, L Buée, B Sablonnière, C Delaby, B Allinquant, A Gabelle, S Bombois, S Lehmann, O Hanon
BACKGROUND AND PURPOSE: Blood-based biomarkers are a non-invasive solution to predict the risk of conversion of mild cognitive impairment (MCI) to dementia. The utility of free plasma amyloid peptides (not bound to plasma proteins and/or cells) as an early indicator of conversion to dementia is still debated, as the results of studies have been contradictory. In this context, we investigated whether plasma levels of the free amyloid peptides Aβ1-42 and Aβ1-40 and the free plasma Aβ1-42 /Aβ1-40 ratio are associated with the conversion of MCI to dementia, in particular AD, over three years of follow-up in a subgroup of the BALTAZAR cohort...
February 27, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38423191/clock-knockout-in-inhibitory-neurons-reduces-predisposition-to-epilepsy-and-influences-anxiety-like-behaviors-in-mice
#24
JOURNAL ARTICLE
Lu Deng, Hong Jiang, Jingjing Lin, Di Xu, Ailin Qi, Qing Guo, Pingping Li, Xinshi Wang, Judy S Liu, Xiaoqin Fu, Peijun Li
Epilepsy is a brain disorder affecting up to 1 in 26 individuals. Despite its clinical importance, the molecular mechanisms of epileptogenesis are still far from clarified. Our previous study showed that disruption of Clock in excitatory neurons alters cortical circuits and leads to generation of focal epilepsy. In this study, a GAD-Cre;Clockflox/flox mouse line with conditional Clock gene knockout in inhibitory neurons was established. We observed that seizure latency was prolonged, the severity and mortality of pilocarpine-induced seizure were significantly reduced, and memory was improved in GAD-Cre;Clockflox/flox mice...
February 27, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38408685/structural-interhemispheric-connectivity-defects-in-mouse-models-of-bbsoas-insights-from-high-spatial-resolution-3d-white-matter-tractography
#25
JOURNAL ARTICLE
Jean Christophe Deloulme, Maxime Leclercq, Olivier Deschaux, Gemma Flore, Laetitia Capellano, Chiara Tocco, Barbara Yael Braz, Michèle Studer, Hana Lahrech
White matter (WM) tract formation and axonal pathfinding are major processes in brain development allowing to establish precise connections between targeted structures. Disruptions in axon pathfinding and connectivity impairments will lead to neural circuitry abnormalities, often associated with various neurodevelopmental disorders (NDDs). Among several neuroimaging methodologies, Diffusion Tensor Imaging (DTI) is a magnetic resonance imaging (MRI) technique that has the advantage of visualizing in 3D the WM tractography of the whole brain non-invasively...
February 24, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38408684/hnrnp-r-regulates-mitochondrial-movement-and-membrane-potential-in-axons-of-motoneurons
#26
JOURNAL ARTICLE
Sophia Dithmar, Abdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis. The RNA-binding protein hnRNP R interacts with different motoneuron disease-related proteins such as SMN and TDP-43 and has important roles in axons of motoneurons, including axonal mRNA transport. However, whether hnRNP R also modulates axonal mitochondria is currently unknown. Here, we show that axonal mitochondria exhibit altered function and motility in hnRNP R-deficient motoneurons...
February 24, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38402912/gene-environment-interaction-elicits-dystonia-like-features-and-impaired-translational-regulation-in-a-dyt-tor1a-mouse-model
#27
JOURNAL ARTICLE
Colette Reinhold, Susanne Knorr, Rhonda L McFleder, Lisa Rauschenberger, Muthuraman Muthuraman, Panagiota Arampatzi, Tom Gräfenhan, Andreas Schlosser, Michael Sendtner, Jens Volkmann, Chi Wang Ip
DYT-TOR1A dystonia is the most common monogenic dystonia characterized by involuntary muscle contractions and lack of therapeutic options. Despite some insights into its etiology, the disease's pathophysiology remains unclear. The reduced penetrance of about 30% suggests that extragenetic factors are needed to develop a dystonic phenotype. In order to systematically investigate this hypothesis, we induced a sciatic nerve crush injury in a genetically predisposed DYT-TOR1A mouse model (DYT1KI) to evoke a dystonic phenotype...
February 23, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38402018/corrigendum-to-reducing-huntingtin-by-immunotherapy-delays-disease-progression-in-a-mouse-model-of-huntington-disease-neurobiology-of-disease-2024-jan-190-106376
#28
Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Staffler, Michael R Hayden, Amber L Southwell
No abstract text is available yet for this article.
February 23, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38401650/suppression-of-presynaptic-corticostriatal-glutamate-activity-attenuates-l-dopa-induced-dyskinesia-in-6-ohda-lesioned-parkinson-s-disease-mice
#29
JOURNAL ARTICLE
Yu-Ting Huang, Ya-Wen Chen, Tze-Yen Lin, Jin-Chung Chen
A common adverse effect of Parkinson's disease (PD) treatment is L-dopa-induced dyskinesia (LID). This condition results from both dopamine (DA)-dependent and DA-independent mechanisms, as glutamate inputs from corticostriatal projection neurons impact DA-responsive medium spiny neurons in the striatum to cause the dyskinetic behaviors. In this study, we explored whether suppression of presynaptic corticostriatal glutamate inputs might affect the behavioral and biochemical outcomes associated with LID. We first established an animal model in which 6-hydroxydopamine (6-OHDA)-lesioned mice were treated daily with L-dopa (10 mg/kg, i...
February 23, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38395315/role-of-soluble-epoxide-hydrolase-in-pain-and-depression-comorbidity
#30
JOURNAL ARTICLE
Yuchen Bu, Siqi Yang, Di Wang, Suwan Hu, Qi Zhang, Zifeng Wu, Chun Yang
The coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression remains elusive. Research conducted in recent decades has uncovered that soluble epoxide hydrolase, a pivotal enzyme in the metabolism of polyunsaturated fatty acids, plays a crucial role in inflammation. Interestingly, this enzyme is intricately linked to the development of both pain and depression...
February 21, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38382884/the-potential-roles-of-salivary-biomarkers-in-neurodegenerative-diseases
#31
REVIEW
Ling-Ling Jiao, Hui-Lin Dong, Meng-Meng Liu, Peng-Lin Wu, Yi Cao, Yuan Zhang, Fu-Gao Gao, Huai-Yuan Zhu
Current research efforts on neurodegenerative diseases are focused on identifying novel and reliable biomarkers for early diagnosis and insight into disease progression. Salivary analysis is gaining increasing interest as a promising source of biomarkers and matrices for measuring neurodegenerative diseases. Saliva collection offers multiple advantages over the currently detected biofluids as it is easily accessible, non-invasive, and repeatable, allowing early diagnosis and timely treatment of the diseases...
February 19, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38378122/transcriptomic-evaluation-of-tau-and-tdp-43-synergism-shows-tauopathy-predominance-and-reveals-potential-modulating-targets
#32
JOURNAL ARTICLE
Vaishnavi S Jadhav, Jade G Stair, Randall J Eck, Samuel N Smukowski, Heather N Currey, Laura Garcia Toscano, Joshua C Hincks, Caitlin S Latimer, Paul N Valdmanis, Brian C Kraemer, Nicole F Liachko
Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the protein TDP-43 as a secondary pathology. The presence of TDP-43 pathology in AD is associated with increased tau neuropathology and worsened clinical outcomes in AD patients. Using C. elegans models of mixed pathology in AD, we have previously shown that TDP-43 specifically synergizes with tau but not Aβ, resulting in enhanced neuronal dysfunction, selective neurodegeneration, and increased accumulation of pathological tau...
February 18, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38369213/ameliorating-effects-of-transcutaneous-auricular-vagus-nerve-stimulation-on-a-mouse-model-of-constipation-predominant-irritable-bowel-syndrome
#33
JOURNAL ARTICLE
Jie Liu, Qian Dai, Tong Qu, Jun Ma, Chaolan Lv, Haitao Wang, Yue Yu
Limited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model of IBS-C. In the current study, C57BL/6 mice were randomly divided into normal control, IBS-C model control, sham-electrostimulation (sham-ES), taVNS, and drug treatment groups. The effects of taVNS on fecal pellet number, fecal water content, and gastrointestinal transit were evaluated in IBS-C model mice...
February 16, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38367882/tdp-43-m323k-causes-abnormal-brain-development-and-progressive-cognitive-and-motor-deficits-associated-with-mislocalised-and-increased-levels-of-tdp-43
#34
JOURNAL ARTICLE
Juan M Godoy-Corchuelo, Zeinab Ali, Jose M Brito Armas, Aurea B Martins-Bach, Irene García-Toledo, Luis C Fernández-Beltrán, Juan I López-Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jimenez-Coca, Ramón A Muñoz de Bustillo Alfaro, Maria J Sánchez-Barrena, Remya R Nair, Brian J Nieman, Jason P Lerch, Karla L Miller, Hande P Ozdinler, Elizabeth M C Fisher, Thomas J Cunningham, Abraham Acevedo-Arozena, Silvia Corrochano
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as "TDP-43 proteinopathies". Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in brains of ~50% of frontotemporal dementia (FTD) patients. While mutations in the TDP-43 gene (TARDBP) are usually associated with ALS, many clinical reports have linked these mutations to cognitive impairments and/or FTD, but also to other neurodegenerative disorders including Parkinsonism (PD) or progressive supranuclear palsy (PSP)...
February 15, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38365045/diffusion-mri-marks-progressive-alterations-in-fiber-integrity-in-the-zq175dn-mouse-model-of-huntington-s-disease
#35
JOURNAL ARTICLE
Nicholas Vidas-Guscic, Joëlle van Rijswijk, Johan Van Audekerke, Ben Jeurissen, Israel Nnah, Haiying Tang, Ignacio Muñoz-Sanjuan, Dorian Pustina, Roger Cachope, Annemie Van der Linden, Daniele Bertoglio, Marleen Verhoye
Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matter-based biomarkers in HD animal models will be important in understanding disease mechanisms and testing the efficacy of therapeutic interventions. Here we investigated the progression of white matter deficits in the knock-in zQ175DN heterozygous (HET) mouse model of HD at 3, 6 and 11 months of age (M), reflecting different states of phenotypic progression...
February 15, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38365046/cognitively-healthy-apoe4-4-carriers-show-white-matter-impairment-associated-with-serum-nfl-and-amyloid-pet
#36
JOURNAL ARTICLE
Claudia Tato-Fernández, Laura L Ekblad, Elina Pietilä, Virva Saunavaara, Semi Helin, Riitta Parkkola, Henrik Zetterberg, Kaj Blennow, Juha O Rinne, Anniina Snellman
Except for aging, carrying the APOE ε4 allele (APOE4) is the most important risk factor for sporadic Alzheimer's disease. APOE4 carriers may have reduced capacity to recycle lipids, resulting in white matter microstructural abnormalities. In this study, we evaluated whether white matter impairment measured by diffusion tensor imaging (DTI) differs between healthy individuals with a different number of APOE4 alleles and whether white matter impairment associates with brain beta-amyloid (Aβ) load and serum levels of neurofilament light chain (NfL)...
February 14, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38341159/navigating-the-future-of-retinitis-pigmentosa-treatments-a-comprehensive-analysis-of-therapeutic-approaches-in-rd10-mice
#37
REVIEW
Hongli Yang, Hui Zhang, Xiaorong Li
Retinitis pigmentosa (RP) is a degenerative disease, caused by genetic mutations that lead to a loss in photoreceptors. For research on RP, rd10 mice, which carry mutations in the phosphodiesterase (PDE) gene, exhibit degenerative patterns comparable to those of patients with RP, making them an ideal model for investigating potential treatments. Although numerous studies have reported the potential of biochemical drugs, gene correction, and stem cell transplantation in decelerating rd10 retinal degeneration, a comprehensive review of these studies has yet to be conducted...
February 8, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38336279/communication-defects-with-astroglia-contribute-to-early-impairments-in-the-motor-cortex-plasticity-of-sod1-g93a-mice
#38
JOURNAL ARTICLE
Sara Costa-Pinto, Joana Gonçalves-Ribeiro, Joana Tedim-Moreira, Renato Socodato, João B Relvas, Ana M Sebastião, Sandra H Vaz
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex (M1). Excitotoxicity in ALS occurs due to an imbalance between excitation and inhibition, closely linked to the loss/gain of astrocytic function. Using the ALS SOD1G93A mice, we investigated the astrocytic contribution for the electrophysiological alterations observed in the M1 of SOD1G93A mice, throughout disease progression. Results showed that astrocytes are involved in synaptic dysfunction observed in presymptomatic SOD1G93A mice, since astrocytic glutamate transport currents are diminished and pharmacological inhibition of astrocytes only impaired long-term potentiation and basal transmission in wild-type mice...
February 7, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38307366/a-systematic-review-and-meta-analysis-of-tau-phosphorylation-in-mouse-models-of-familial-alzheimer-s-disease
#39
REVIEW
Malamati Kourti, Athanasios Metaxas
Transgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this meta-analysis, we sought to evaluate levels of phosphorylated tau (p-tau) and explore potential age-related variations in tau hyperphosphorylation, within mouse models of AD. The PubMed and Scopus databases were searched for studies measuring soluble p-tau in 5xFAD, APPswe /PSEN1de9 , J20 and APP23 mice. Data were extracted and analyzed using standardized procedures...
February 1, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38307367/tgr5-signalling-in-heart-and-brain-injuries-focus-on-metabolic-and-ischaemic-mechanisms
#40
JOURNAL ARTICLE
Nan Xu, Yufeng He, Chunyu Zhang, Yongqiang Zhang, Shengjie Cheng, Li Deng, Yi Zhong, Bin Liao, Yan Wei, Jian Feng
The heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function. The relationship between the heart and brain is being continuously investigated. Evidence-based medicine has revealed the concept of the "heart- brain axis," which may provide new therapeutic strategies for certain diseases. Takeda protein-coupled receptor 5 (TGR5) is a metabolic regulator involved in energy homeostasis, bile acid homeostasis, and glucose and lipid metabolism...
January 31, 2024: Neurobiology of Disease
journal
journal
32145
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.