Brigitte Tardy-Poncet, Aurélie Montmartin, Hervé Chambost, Anne Lienhart, Birgit Frotscher, Pierre-Emmanuel Morange, Céline Falaise, Fanny Collange, Yesim Dargaud, Marie Toussaint-Hacquard, Laurent Ardillon, Bénédicte Wibaut, Emmanuelle Jeanpierre, Philippe Nguyen, Fabienne Volot, Bernard Tardy
INTRODUCTION: Bleeding severity in severe haemophilic patients, with low thrombin generation (TG) capacity, can vary widely between patients, possibly reflecting differences in tissue factor pathway inhibitor (TFPI) level. AIM: To compare free TFPI (fTFPI) levels in patients with severe haemophilia A (sHA) and severe haemophilia B (sHB) and to investigate in these patients as a whole the relationships between bleeding and TG potential, between TG potential and fTFPI level and between fTFPI level and bleeding tendency...
April 22, 2024: Haemophilia: the Official Journal of the World Federation of Hemophilia