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Journal of Cardiac Failure

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https://www.readbyqxmd.com/read/28918108/heart-failure-with-recovered-ejection-fraction-in-african-americans-results-from-the-african-american-heart-failure-trial
#1
Kay-Won Chang, Neil Beri, Nghia H Nguyen, Boris Arbit, Sutton Fox, Sean Mojaver, Paul Clopton, S William Tam, Anne L Taylor, Jay N Cohn, Alan S Maisel, Inder S Anand
BACKGROUND: Recent studies have described the entity of heart failure with recovered ejection fraction (HFrecEF), but population specific studies remain lacking. The aim of this study was to characterize patients enrolled in the African-American Heart Failure Trial (A-HeFT) who had significant improvement in their ejection fraction (EF) during the first 6 months of follow-up. METHODS AND RESULTS: Subjects (n = 59) with HFrecEF (improvement in EF from < 35% to > 40% in 6 months) were compared to 259 with heart failure and persistently reduced EF (HFrEF), defined as EF ≤ 40% at 6 month follow-up...
September 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28916479/dietary-nitrate-increases-vo2peak-and-performance-but-does-not-alter-ventilation-or-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#2
Andrew R Coggan, Seth R Broadstreet, Kiran Mahmood, Deana Mikhalkova, Michael Madigan, Indra Bole, Soo Park, Joshua L Leibowitz, Ana Kadkhodayan, Deepak P Thomas, Dakkota Thies, Linda R Peterson
BACKGROUND: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak O2 uptake (VO2peak) during exercise. Dietary nitrate (NO3(-)), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3(-) ingestion on exercise responses in eight patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. METHODS AND RESULTS: Plasma NO3(-), nitrite (NO2(-)), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11...
September 12, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28911810/exercise-ve-vco2-slope-an-endurance-marker-of-prognosis-in-patients-with-hfpef-and-pulmonary-hypertension-at-least
#3
EDITORIAL
Marco Guazzi
No abstract text is available yet for this article.
September 11, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28893677/accuracy-of-self-reported-heart-failure-the-atherosclerosis-risk-in-communities-aric-study
#4
Ricky Camplain, Anna Kucharska-Newton, Laura Loehr, Thomas C Keyserling, J Bradley Layton, Lisa Wruck, Aaron R Folsom, Alain G Bertoni, Gerardo Heiss
OBJECTIVE: To estimate agreement of self-reported heart failure (HF) with physician diagnosed HF and compare the prevalence of HF by method of ascertainment. STUDY DESIGN AND SETTING: ARIC cohort members (60-83 years of age) were asked annually whether a physician indicated they have HF. For those self-reporting HF, physicians were asked to confirm their patient's HF status. Physician diagnosed HF included surveillance of hospitalized HF, and hospitalized and outpatient HF identified in administrative claims databases...
September 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28888840/teneligliptin-prevents-cardiomyocyte-hypertrophy-fibrosis-and-development-of-hypertensive-heart-failure-in-dahl-salt-sensitive-rats
#5
Masayoshi Yamamoto, Tomoko Ishizu, Yoshihiro Seo, Yoshimi Suto, Seika Sai, Dongzhu Xu, Nobuyuki Murakoshi, Taizo Kimura, Yasushi Kawakami, Kazutaka Aonuma
BACKGROUND: We investigated the effects of the DPP4 inhibitor, teneligliptin, on cardiac function and hemodynamics during heart failure in hypertensive model rats. METHODS AND RESULTS: Fifty-five male Dahl salt-sensitive rats were divided into four groups: control group (0.3% NaCl chow, n=13), hypertension (HT) group (8% NaCl chow, n=20), HT-early TNL group (8% NaCl chow and teneligliptin from 6 weeks, n=10), and HT-late TNL group (8% NaCl chow and teneligliptin from 10 weeks, n=12)...
September 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28887109/early-identification-of-patients-with-acute-decompensated-heart-failure
#6
Saul Blecker, David Sontag, Leora I Horwitz, Gilad Kuperman, Hannah Park, Alex Reyentovich, Stuart D Katz
BACKGROUND: Interventions to reduce readmissions following acute heart failure hospitalization require early identification of patients. The purpose of this study was to develop and test accuracies of various approaches to identify patients with acute decompensated heart failure (ADHF) using data derived from the electronic health record. METHODS AND RESULTS: We included 37,229 hospitalizations of adult patients at a single hospital in 2013-2015. We developed four algorithms to identify hospitalization with a principal discharge diagnosis of ADHF: 1) presence of one of three clinical characteristics; 2) logistic regression of 31 structured data elements; 3) machine learning with unstructured data; 4) machine learning with both structured and unstructured data...
September 5, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28870732/processes-and-outcomes-of-congestive-heart-failure-care-by-different-types-of-primary-care-models
#7
Yong-Fang Kuo, Deepak Adhikari, Chiemeziem G Eke, James S Goodwin, Mukaila A Raji
BACKGROUND: Having nurse practitioners (NPs) as primary care providers for patients with congestive heart failure (CHF) is one way to address the growing shortage of primary care physicians (PCPs). METHODS AND RESULTS: We used inverse probability of treatment weighted with propensity score to examine the processes and outcomes of care for patients under three care models. Approximately 72.9%, 0.8%, and 26.3% of CHF patients received care under the PCP model, the NP model, and the shared care model, respectively...
September 1, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28870731/chronic-neuregulin-1%C3%AE-treatment-mitigates-the-progression-of-post-myocardial-infarction-heart-failure-in-the-setting-of-type-1-diabetes-mellitus-by-suppressing-myocardial-apoptosis-fibrosis-and-key-oxidant-producing-enzymes
#8
Manisha Gupte, Hind Lal, Firdos Ahmad, Douglas B Sawyer, Michael F Hill
BACKGROUND: Type 1 diabetes mellitus (DM) patients surviving myocardial infarction (MI) have substantially higher cardiovascular morbidity and mortality compared to their non-diabetic counterparts owing to the more frequent development of subsequent heart failure (HF). Neuregulin (NRG)-1β is released from cardiac microvascular endothelial cells and acts as a paracrine factor via the ErbB family of tyrosine kinase receptors expressed in cardiac myocytes to regulate cardiac development and stress responses...
September 1, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28847521/an-innovative-approach-to-increasing-donor-heart-supply-will-it-work
#9
EDITORIAL
Kevin J O'Connor
No abstract text is available yet for this article.
August 26, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28847522/universal-coverage-for-heart-failure-diagnosis-and-treatment-looking-from-sub-saharan-africa-to-central-australia
#10
EDITORIAL
Gene Bukhman, Frederick Ochieng
No abstract text is available yet for this article.
August 25, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28842381/clinical-decision-support-for-heart-failure-referral-more-work-better-outcomes
#11
EDITORIAL
Justin M Vader, Shane J La Rue
No abstract text is available yet for this article.
August 23, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28842380/brief-report-patient-activation-among-urban-hospitalized-patients-with-heart-failure
#12
Ruth Masterson Creber, Ting Chen, Chao Wei, Christopher S Lee
BACKGROUND: Patient activation influences patients' ability to meaningfully engage in critical heart failure self-care. The purpose of this study was to identify whether patient activation is associated with patient-reported health outcomes in an urban and racially diverse inpatient sample of patients with heart failure. METHODS: We prospectively recruited patients with heart failure hospitalized at an urban academic medical center from October 2016 to May 2017 and measured patient activation, physical and affective symptoms, physical function, self-care, perceived control, and self-efficacy...
August 23, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28842379/weblogs-a-complex-data-source-for-qualitative-research
#13
LETTER
Melissa I Owen, Lynne T Braun, Rebekah J Hamilton, Kathleen L Grady, Rebecca A Gary, Tammie E Quest
BACKGROUND: Social media has allowed patients and families to document the chronic illness experience though first person narratives in the form of blogs. Blogs give insight in the experience through a first-person perspective. Blogs can be used in qualitative research, but the methodology may be complicated. METHOD AND RESULTS: A study exploring the experience of heart transplant candidates was conducted using blog and interview analysis. Specific questions to be answered related to blog methodology included privacy concerns, sample size, missing demographics, and lack of opportunity for clarification...
August 22, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28842378/end-of-life-discussions-in-patients-with-heart-failure
#14
Kathleen A Young, Margaret M Redfield, Jacob J Strand, Shannon M Dunlay
BACKGROUND: Although guidelines call on clinicians to conduct regular conversations about advance care planning and end-of-life (EOL) preferences with patients with heart failure (HF), research suggests that physicians often avoid these discussions. METHODS AND RESULTS: Between January 20, 2014 and January 18, 2016, Southeastern Minnesota residents hospitalized with acute decompensated HF (ADHF) at Mayo Clinic hospitals were enrolled into an observational cohort study that included the administration of face-to-face questionnaires...
August 22, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28821391/clinical-decision-support-to-efficiently-identify-patients-eligible-for-advanced-heart-failure-therapies
#15
R Scott Evans, Abdallah G Kfoury, Benjamin D Horne, James F Lloyd, Jose Benuzillo, Kismet D Rasmusson, Colleen Roberts, Donald L Lappé
BACKGROUND: Patients who need and receive timely advanced heart failure (HF) therapies have better long-term survival. However, many of these patients are not identified and referred as soon as they should be. METHODS: A clinical decision support (CDS) application sent secure email notifications to HF patients' providers when they transitioned to advanced disease. Patients identified with CDS in 2015 were compared with control patients from 2013 to 2014. Kaplan-Meier methods and Cox regression were used in this intention-to-treat analysis to compare differences between visits to specialized and survival...
August 16, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801077/myocardial-amyloid-quantification-with-look-locker-magnetic-resonance-sequence-in-cardiac-amyloidosis-diagnostic-accuracy-in-clinical-practice-and-histological-validation
#16
Eduardo Pozo, Jose M Castellano, Anubhav Kanwar, Rajiv Deochand, Mireia Castillo-Martin, Pablo Pazos-López, Carlos González-Lengua, Keren Osman, Matthew Cham, Carlos Cordon-Cardo, Jagat Narula, Valentin Fuster, Javier Sanz
BACKGROUND: Cardiac magnetic resonance (CMR) has demonstrated its utility in the non-invasive diagnosis of cardiac amyloidosis (CA). Our aim was to evaluate the ability of standard Look-Locker sequences to quantify amyloid deposition in CA. METHODS AND RESULTS: Consecutive patients referred for CMR for possible CA were retrospectively evaluated. Positive cardiac biopsy and/or typical pattern of late gadolinium enhancement were required for the diagnosis of CA. Post-contrast T1 values were obtained from Look-Locker sequences, and correlated with markers of severity of disease and major events...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801076/early-development-of-right-ventricular-ischemic-lesions-in-a-novel-large-animal-model-of-acute-right-heart-failure-in-chronic-thromboembolic-pulmonary-hypertension
#17
David Boulate, Jennifer Arthur Ataam, Andrew J Connolly, Genevieve Giraldeau, Myriam Amsallem, Benoit Decante, Lilia Lamrani, Elie Fadel, Peter Dorfmuller, Frederic Perros, Francois Haddad, Olaf Mercier
BACKGROUND: Our aim was to develop a model of acute right heart failure (ARHF) in the setting of pulmonary hypertension and to characterize acute right ventricular lesions that develop early after hemodynamic restoration. METHODS AND RESULTS: We used a described piglet model of chronic pulmonary hypertension (cPH) induced by pulmonary artery occlusions. We induced ARHF in animals with cPH (ARHF-cPH group, n = 9) by volume loading and iterative acute pulmonary embolism until hemodynamic compromise followed by dobutamine infusion for hemodynamic restoration before sacrifice for right ventricular tissue evaluation...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801075/doppler-assessment-of-diastolic-function-reflect-the-severity-of-injury-in-rats-with-chronic-heart-failure
#18
Pablo Sanchez, Jordan J Lancaster, Kyle Weigand, Saffie-Alrahman Ezz-Eldin Mohran, Steven Goldman, Elizabeth Juneman
OBJECTIVE: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801074/rational-heart-transplant-from-hepatitis-c-donor-new-antiviral-weapons-conquer-the-trojan
#19
Robert L Gottlieb, Teena Sam, Suzanne Y Wada, James F Trotter, Sumeet K Asrani, Brian Lima, Susan M Joseph, Gonzalo Gonzalez-Stawinski, Shelley A Hall
BACKGROUND: Donors with hepatitis C (HCV) viremia are rarely utilized for orthotopic heart transplantation (OHTx) due to post-transplant risks. New, highly effective HCV antivirals may alter the landscape. METHODS: An adult patient unsuitable for bridging mechanical support therapy accepted a heart transplant offer from a donor with HCV viremia. Upon daily logarithmic rise in HCV viral load and adequate titers to ensure successful genotyping, once daily sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa) was initiated empirically pending HCV genotype (genotype 3a confirmed after initiation of therapy)...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28797824/response-to-letter-to-the-editor-by-mr-john-renesch
#20
LETTER
Michael W Rich, Suzanne J Wingate
No abstract text is available yet for this article.
August 7, 2017: Journal of Cardiac Failure
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