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Journal of Cardiac Failure

Jonah Rubin, D Eric Steidley, Martin Carlsson, Moh-Lim Ong, Mathew S Maurer
BACKGROUND: Transthyretin amyloidosis (ATTR) is often associated with cardiac involvement manifesting as conduction disease as well as a restrictive cardiomyopathy causing heart failure and death. Myocardial contraction fraction (MCF), the ratio of left ventricular stroke volume (SV) to myocardial volume (MV), is a volumetric measure of myocardial shortening that is superior to EF in predicting mortality in patients with primary amyloid light chain (AL) cardiac amyloidosis. We hypothesized that MCF would be an independent predictor of survival in ATTR...
July 12, 2018: Journal of Cardiac Failure
Bunny J Pozehl, Rita McGuire, Kathleen Duncan, Kevin Kupzyk, Joseph Norman, Nancy T Artinian, Pallav Deka, Steven K Krueger, Matthew A Saval, Steven J Keteyian
BACKGROUND: Few exercise training studies in patients with heart failure (HF) report adherence to guideline-recommended 150 minutes of moderate intensity exercise per week and no studies have focused on a primary outcome of adherence. METHODS AND RESULTS: This randomized controlled trial evaluated the effect of a multi-component intervention (Heart failure Exercise And Resistance Training Camp - HEART Camp) on adherence to exercise (6, 12 and 18 months) compared to an enhanced usual care (EUC) group...
July 12, 2018: Journal of Cardiac Failure
Shinya Tanaka, Kentaro Kamiya, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Takashi Masuda, Junya Ako
BACKGROUND: The impact of frailty on long-term prognosis in patients with heart failure (HF) remains unclear, and there is no simple and objective assessment for it. This study was performed to examine the association between frailty score and clinical outcome in elderly patients hospitalized for HF. METHODS AND RESULTS: A retrospective cohort study was performed in 603 elderly patients with HF (mean age: 75±6 years, 378 men; 62.7%). Frailty was measured by a composite of four markers combined into a frailty score (possible range 0-12): gait speed, handgrip strength, serum albumin, and activities of daily living status...
July 12, 2018: Journal of Cardiac Failure
Nwora Lance Okeke, Fawaz Alenezi, Gerald S Bloomfield, Allison Dunning, Meredith E Clement, Svati H Shah, Susanna Naggie, Eric J Velazquez
OBJECTIVE: To investigate determinants of structural myocardial abnormalities in persons living with HIV (PLWH). METHODS: We reviewed archived transthoracic echocardiograms (TTE) performed on PLWH at Duke University Medical Center between 2001 and 2012. The primary outcomes were presence of left ventricular hypertrophy (LVH) or diastolic dysfunction (DD). RESULTS: TTEs for 498 HIV-infected persons were reviewed (median age 44 yrs, 38% female, 72% Black, 34% with hypertension, 15% with diabetes)...
June 29, 2018: Journal of Cardiac Failure
Renata De Maria
No abstract text is available yet for this article.
June 25, 2018: Journal of Cardiac Failure
Taiki Sakaguchi, Akio Hirata, Kazunori Kashiwase, Yoshiharu Higuchi, Tomohito Ohtani, Yasushi Sakata, Yoshio Yasumura
BACKGROUND: Although central venous pressure (CVP) is a surrogate measure of preload in patients with acute decompensated heart failure (ADHF), it is a multifactorial index influenced not only by fluid volume status, but also by cardiac pump function and other factors. We aimed to elucidate the individual pathophysiologic factors of CVP elevation in ADHF patients by assessing the relationship between CVP and extracellular fluid volume status (EVS). METHODS AND RESULTS: We quantified EVS in 100 ADHF patients using bioelectrical impedance analysis...
June 8, 2018: Journal of Cardiac Failure
Ganapathi Sanjay, Panniyammakal Jeemon, Anubha Agarwal, Sunitha Viswanathan, Madhu Sreedharan, Vijayaraghavan Govindan, Bahuleyan Charantharalyil Gopalan, R Biju, Tiny Nair, N Prathapkumar, G Krishnakumar, N Rajalekshmi, Krishnan Suresh, Lawrence P Park, Mark D Huffman, Sivadasanpillai Harikrishnan
BACKGROUND: Long-term data on outcomes of participants hospitalized with heart failure (HF) from low and middle-income countries are limited. METHODS AND RESULTS: In the Trivandrum Heart Failure Registry (THFR) in 2013, 1205 participants from 18 hospitals in Trivandrum, India were enrolled. Data were collected on demographics, clinical presentation, treatment and outcomes. We performed survival analyses, compared groups and evaluated the association between HF type and mortality, adjusting for covariates that predicted mortality in a global HF risk score...
June 6, 2018: Journal of Cardiac Failure
Matthew S Delfiner, Colleen Nofi, Ying Li, A Martin Gerdes, Youhua Zhang
BACKGROUND: Both vagal (VS) and sympathetic (SS) stimulations can increase atrial fibrillation (AF) inducibility, with VS being known as more arrhythmogenic in normal hearts. Heart failure (HF) results in autonomic dysfunction (characterized by sympathetic activation and vagal withdrawal) and is associated with an increased AF incidence. This study investigated whether failing hearts, compared to normal-controls, respond differently to autonomic stimulation induced AF arrhythmogenesis and the effect of dantrolene on SS enhanced AF in HF...
June 6, 2018: Journal of Cardiac Failure
Christian Jung, Bernhard Wernly, Mikael Bjursell, John Wiseman, Therese Admyre, Johannes Wikström, Malin Palmér, Frank Seeliger, Michael Lichtenauer, Marcus Franz, Charlotte Frick, Ann-Katrin Andersson, Margareta Elg, John Pernow, Per-Ove Sjöquist, Mohammad Bohlooly-Y, Qing-Dong Wang
BACKGROUND: Oxytocin (Oxt) and its receptor (Oxtr) gene system has been implicated in cardiomyogenesis and cardioprotection; however, effects of chronic activation of Oxtr are not known. We generated and investigated transgenic (TG) mice that overexpress Oxtr specifically in the heart. METHODS AND RESULTS: Cardiac-specific overexpression of Oxtr was obtained by having the α-major histocompatibility complex promoter drive the mouse Oxtr gene (α-Mhc-Oxtr). Left ventricular (LV) function and remodeling were assessed by magnetic resonance imaging and echocardiography...
May 23, 2018: Journal of Cardiac Failure
Merrick Miles, Bret D Alvis, Kyle Hocking, Franz Baudenbacher, Christy Guth, Joann Lindenfeld, Colleen Brophy, Susan Eagle
BACKGROUND: To determine the feasibility of peripheral intravenous volume analysis (PIVA) of venous waveforms for assessing volume overload in patients admitted to the hospital with acute decompensated heart failure (ADHF). METHODS: Venous waveforms were captured from a peripheral intravenous catheter in subjects admitted for ADHF and healthy age-matched controls. Admission PIVA signal, brain natriuretic peptide, and chest radiographic measurements were related to the net volume removed during diuresis...
May 16, 2018: Journal of Cardiac Failure
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
BACKGROUND: Because neprilysin is involved in the degradation of amyloid-beta, there is concern that the angiotensin-neprilysin inhibitor sacubitril-valsartan could increase the risk for dementia. METHODS: We analyzed adverse event cases submitted to the Food and Drug Administration Adverse Event Report System from July 2015 to March 2017. Cognition- and dementia-related adverse event cases were defined with the use of broad and narrow structured medical queries...
May 7, 2018: Journal of Cardiac Failure
Amichai Perlman, Bruria Hirsh Raccah, Ilan Matok, Mordechai Muszkat
The Publisher regrets that this article is an accidental duplication of an article that has already been published, The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at
May 7, 2018: Journal of Cardiac Failure
Ashish Correa, Achint Patel, Kinsuk Chauhan, Harshil Shah, Aparna Saha, Mihir Dave, Priti Poojary, Abhishek Mishra, Narender Annapureddy, Shaman Dalal, Ioannis Konstantinidis, Renu Nimma, Shiv Kumar Agarwal, Lili Chan, Girish Nadkarni, Sean Pinney
BACKGROUND: Dialysis-requiring acute kidney injury (D-AKI) is a serious complication in hospitalized heart failure (HF) patients. However, data on national trends are lacking after 2002. METHODS: We used the Nationwide Inpatient Sample (2002-2013) to identify HF hospitalizations with and without D-AKI. We analyzed trends in incidence, in-hospital mortality, length of stay (LoS), and cost. We calculated adjusted odds ratios (aORs) for predictors of D-AKI and for outcomes including in-hospital mortality and adverse discharge (discharge to skilled nursing facilities, nursing homes, etc)...
May 3, 2018: Journal of Cardiac Failure
Edimar Alcides Bocchi, Fátima das Dores da Cruz, Sara Michelly Brandão, Victor Issa, Silvia Moreira Ayub-Ferreira, Hans-Peter Brunner la Rocca, Sandra Sanders-van Wijk
BACKGROUND: Published studies have generated mixed, controversial results regarding the cost-effectiveness of heart failure disease management programs (HF-DMPs). This study assessed the cost-effectiveness of an HF-DMP in ambulatory patients compared with usual care (UC). METHODS: In the prospective randomized REMADHE trial, we evaluated incremental costs per quality-adjusted life-year (QALY) and life-year (LY) gained as effectiveness ratios (ICERs) over a study period of 2...
April 30, 2018: Journal of Cardiac Failure
Brendan J Carry, Stuart D Katz
No abstract text is available yet for this article.
April 26, 2018: Journal of Cardiac Failure
Paul J Hauptman
No abstract text is available yet for this article.
June 2018: Journal of Cardiac Failure
Bo Xu, Allan L Klein
No abstract text is available yet for this article.
June 2018: Journal of Cardiac Failure
John Gorcsan
No abstract text is available yet for this article.
June 2018: Journal of Cardiac Failure
Karen Distelhorst, Renee Claussen, Kelly Dion, James F Bena, Shannon L Morrison, Donna Walker, Hua-Li Tai, Nancy M Albert
BACKGROUND: Follow-up within 14 days after hospital discharge for heart failure (HF) may prevent 30-day hospital readmission, but adherence varies. The purpose of this study was to determine predictors of nonadherence to scheduled appointments. METHODS AND RESULTS: A medical record review included patients hospitalized for decompensated HF at 3 health system hospitals who had a scheduled 14-day office appointment. Patient demographics, and social, HF, and hospital factors were studied for association with appointment adherence...
June 2018: Journal of Cardiac Failure
Paul J Hauptman
No abstract text is available yet for this article.
May 2018: Journal of Cardiac Failure
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