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Journal of Cardiac Failure

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https://www.readbyqxmd.com/read/29337281/clinical-significance-of-early-fluid-and-weight-change-during-acute-heart-failure-hospitalization
#1
John D Groarke, Susanna R Stevens, Robert J Mentz, Lauren B Cooper, Justin M Vader, Omar F AbouEzzeddine, Justin L Grodin, Emer Joyce, Kevin J Anstrom, G Michael Felker, Margaret M Redfield, Lynne Warner Stevenson, Anuradha Lala
AIMS: To explore the association of changes in weight and fluid during treatment for acute heart failure (AHF) with clinical endpoints. METHODS AND RESULTS: Weight and net fluid changes recorded at 72-96 hours in 708 AHF patients enrolled in DOSE-HF, CARRESS-HF or ROSE-AHF, were compared to freedom from congestion at 72-96 hours and a composite end point of death, re-hospitalization, and unplanned hospital visit at 60 days. Weight loss was concordant with net fluid loss in 55%, discordant and less than expected for fluid loss in 34%, and paradoxically discordant or more than expected for fluid loss in 11% of patients...
January 11, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29329950/dual-vasopressin-v1a-v2-antagonism-the-next-step-in-neurohormonal-modulation-in-patients-with-heart-failure
#2
LETTER
Steven R Goldsmith, James E Udelson, Mihai Gheorghiade
No abstract text is available yet for this article.
January 9, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29329949/running-out-of-success-in-hf-therapy
#3
EDITORIAL
Lars H Lund
No abstract text is available yet for this article.
January 9, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325797/consequences-of-retained-defibrillator-and-pacemaker-leads-following-heart-transplantation-an-underrecognized-problem
#4
Luise Holzhauser, Teruhiko Imamura, Hemal M Nayak, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Sara Kalantari, David Onsager, Tae Song, Takeyoshi Ota, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
BACKGROUND: Cardiovascular implantable electronic devices (CIED) are common in patients undergoing heart transplantation (HT) and complete removal is not always possible at the time of transplant. METHODS: We retrospectively assessed the frequency of retained CIED leads and clinical consequences in consecutive HT patients from 2013-2016. Clinical outcomes included bacteremia, upper extremity deep venous thrombosis (UEDVT), lead migration and inability to perform MRI...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325796/lcz696-sacubitril-valsartan-an-angiotensin-receptor-neprilysin-inhibitor-attenuates-cardiac-hypertrophy-fibrosis-and-vasculopathy-in-a-rat-model-of-chronic-kidney-disease
#5
Yasunori Suematsu, Wanghui Jing, Ane Nunes, Moti L Kashyap, Mahyar Khazaeli, Nosratola D Vaziri, Hamid Moradi
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiac hypertrophy, fibrosis and increased risk of cardiovascular mortality. LCZ696 (Sacubitril/valsartan) is a promising agent which has shown significant potential in treatment of heart failure. We hypothesized that LCZ696 is more effective than valsartan alone in treatment of cardiovascular abnormalities associated with experimental CKD. METHODS AND RESULTS: Male Sprague Dawley rats underwent 5/6 nephrectomy and were subsequently randomized to no treatment (CKD), 30 mg/kg valsartan (VAL), or 60 mg/kg LCZ696 (LCZ)...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325795/insertional-mutagenesis-confounds-the-mechanism-of-the-morbid-phenotype-of-a-plnr9c-transgenic-mouse-line
#6
Alexander Kraev
BACKGROUND: A mouse line with heterozygous transgenic expression of phospholamban carrying a substitution of cysteine for arginine 9 (TgPLNR9C) under the control of α-myosin heavy chain (αMHC) promoter features dilated cardiomyopathy, heart failure and premature death. METHODS AND RESULTS: Determination of transgene chromosomal localization by conventional methods shows that in this line the transgenic array of 13 PLNR9C expression cassettes, arranged in a head-to-tail tandem orientation, has integrated into the bi-directional promoter of the αMHC (Myh6) gene and the gene for the regulatory non-coding RNA Myheart (Mhrt), both of which are known to be involved in cardiac development and pathology...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29325794/association-of-posture-and-ambulation-with-function-at-30-days-post-hospital-discharge-in-older-adults-with-heart-failure
#7
Theresa A Floegel, Jared M Dickinson, Cheryl DerAnanian, Marianne McCarthy, Steven P Hooker, Matthew P Buman
PURPOSE: To investigate the predictive value of in-hospital posture and ambulatory activity for 30-d following discharge on functional status in older patients with heart failure. METHODS: Prospective observational pilot study of 27 patients (78 ± 9.8yrs; 51.8% female) admitted with heart failure. Participants wore two inclinometric accelerometers to record posture in-hospital, and an ankle accelerometer to record ambulatory activity in-hospital and 30 days after discharge...
January 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29305971/more-than-meets-the-eye-time-for-a-new-imaging-paradigm-to-test-for-cardiac-amyloidosis
#8
EDITORIAL
Mathew S Maurer, Frederick L Ruberg, Jonathan W Weinsaft
No abstract text is available yet for this article.
January 3, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29305970/does-neprilysin-inhibition-potentiate-or-minimize-the-adverse-effects-of-glucagon-like-peptide-1-receptor-agonists-in-chronic-heart-failure
#9
EDITORIAL
Milton Packer
No abstract text is available yet for this article.
January 3, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29305186/time-course-of-common-clinical-manifestations-in-patients-with-transthyretin-cardiac-amyloidosis-delay-from-symptom-onset-to-diagnosis
#10
LETTER
Nikolaos Papoutsidakis, Edward J Miller, Anna Rodonski, Daniel Jacoby
BACKGROUND: Cardiac transthyretin amyloidosis (aTTR-CA) is an increasingly recognized cause of heart failure and carries an unfavorable prognosis. There has been no systematic investigation of how long prodromal symptoms are present before the diagnosis of aTTR-CA. We sought to document the type, frequency and distribution of early clinical manifestations in aTTR-CA in order to identify the earliest possible time window for diagnosis. METHODS AND RESULTS: Medical records of 34 aTTR-CA patients with heart failure (29 males, mean age 73...
January 2, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29292112/effects-of-transcatheter-mitral-valve-repair-with-mitraclip-on-left-ventricular-and-atrial-hemodynamic-load-and-myocardial-wall-stress
#11
S E van Wijngaarden, V Kamperidis, I Al-Amri, F van der Kley, M J Schalij, N Ajmone Marsan, J J Bax, V Delgado
AIMS: To evaluate the effects of MitraClip on left ventricular (LV) and left atrial (LA) myocardial wall stress as assessed with N-terminal pro-brain natriuretic peptide (NT-proBNP) and strain imaging. METHODS AND RESULTS: Sixty-five patients with symptomatic moderate and severe mitral regurgitation (MR) (age 75±9 years, 57% male, 89% functional MR) treated with MitraClip were evaluated. Patients were divided according to the 6-month NT-proBNP tertiles. Changes in echocardiographic parameters over 6 months were assessed...
December 29, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29289723/diaphragm-muscle-dysfunction-in-patients-with-heart-failure
#12
Mari Miyagi, Yoshiharu Kinugasa, Takeshi Sota, Kensaku Yamada, Takuya Ishisugi, Masayuki Hirai, Kiyotaka Yanagihara, Nobuhiko Haruki, Koichi Matsubara, Masahiko Kato, Kazuhiro Yamamoto
BACKGROUND: Inspiratory muscle weakness is associated with the development of exercise intolerance in patients with heart failure (HF). Ultrasound assessment of the diaphragm is used to evaluate respiratory muscle function, but its application in patients with HF remains undefined. We examined the relationship of diaphragm function as assessed by ultrasonography with inspiratory muscle strength and exercise tolerance in HF. METHODS AND RESULTS: Seventy-seven patients hospitalized with HF were enrolled...
December 28, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29247707/the-nitrate-nitrite-no-pathway-as-a-novel-therapeutic-target-in-heart-failure-with-reduced-ejection-fraction
#13
EDITORIAL
Julio A Chirinos
No abstract text is available yet for this article.
December 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29197548/right-heart-dysfunction-in-heart-failure-with-preserved-ejection-fraction-the-impact-of-atrial-fibrillation
#14
Thomas M Gorter, Joost P van Melle, Michiel Rienstra, Barry A Borlaug, Yoran M Hummel, Isabelle C Van Gelder, Elke S Hoendermis, Adriaan A Voors, Dirk J Van Veldhuisen, Carolyn S P Lam
BACKGROUND: Right ventricular (RV) dysfunction and atrial fibrillation (AF) frequently coexist in heart failure with preserved ejection fraction (HFpEF). The mechanisms underlying the association between AF and RV dysfunction are incompletely understood. METHODS AND RESULTS: 102 patients were identified. RV function was assessed using multiple echocardiographic parameters and dysfunction was present if ≥2 parameters were below the recommended cutoff. RV function, right atrial (RA) reservoir strain and RA emptying fraction, were compared between AF and sinus rhythm...
November 29, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29180305/pulmonary-vascular-resistance-during-exercise-predicts-long-term-outcomes-in-heart-failure-with-preserved-ejection-fraction
#15
Wei Huang, Rudolf K F Oliveira, Han Lei, David M Systrom, Aaron B Waxman
BACKGROUND: In heart failure with preserved ejection fraction (HFpEF), the prognostic value of pulmonary vascular dysfunction (PV-dysfunction), identified by elevated PVR at peak exercise, is not completely understood. We evaluated the long-term prognostic implications of PV-dysfunction in HFpEF during exercise in consecutive patients undergoing invasive cardiopulmonary exercise testing for unexplained dyspnea. METHODS: Patients with HFpEF were classified into two main groups: resting-HFpEF (rHFpEF;n=104, 62% female, 61-yrs) with a pulmonary arterial wedge pressure (PAWP)>15mmHg at rest; and exercise-HFpEF (eHFpEF;n=81) with a PAWP<15mmHg at rest, but >20mmHg during exercise...
November 24, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29175281/predicting-survival-in-heart-failure-patients-with-an-implantable-cardioverter-defibrillator-the-heart-failure-meta-score
#16
Ana C Alba, Stephen D Walter, Gordon H Guyatt, Wayne C Levy, Jiming Fang, Heather J Ross, Douglas S Lee
BACKGROUND: Prognostic evaluation in heart failure (HF) is important to predict future events and decide timely management. Many HF patients are treated with an implantable cardioverter defibrillator (ICD). This study aimed to validate a meta-analytically-derived prognostic score to predict survival in ICD-HF patients. METHODS AND RESULTS: The HF Meta-Score includes 14 independent mortality predictors identified in a meta-analysis, including age, sex, ethnicity, diabetes, chronic obstructive pulmonary disease, peripheral vascular disease, atrial fibrillation, ischemic cardiomyopathy, history of heart failure admission, NYHA class, left ventricular ejection fraction, renal function, QRS duration, secondary prevention indication and ICD shocks...
November 22, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29275923/global-health-and-heart-failure
#17
EDITORIAL
Paul J Hauptman
No abstract text is available yet for this article.
January 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29158065/electrocardiographic-predictors-of-morbidity-and-mortality-in-patients-with-acute-myocarditis-the-importance-of-qrs-t-angle
#18
Shmuel Chen, Sarah Hoss, Vicki Zeniou, Ayelet Shauer, Dan Admon, Donna R Zwas, Chaim Lotan, Andre Keren, Israel Gotsman
BACKGROUND: Acute myocarditis carries a variable prognosis. We evaluated the morbidity and mortality rates in patients with acute myocarditis and admission electrocardiographic predictors of outcome. METHODS AND RESULTS: Patients admitted to a tertiary hospital with a clinical diagnosis of acute myocarditis were evaluated; 193 patients were included. Median follow-up was 5.7 years, 82% were male, and overal median age was 30 years (range 21-39). The most common clinical presentations were chest pain (77%) and fever (53%)...
January 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29104082/how-we-are-doing-the-journal-enters-its-25th-year
#19
EDITORIAL
Paul J Hauptman
No abstract text is available yet for this article.
December 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28970073/outcomes-of-restrictive-and-hypertrophic-cardiomyopathies-after-lvad-an-intermacs-analysis
#20
Snehal R Patel, Omar Saeed, David Naftel, Susan Myers, James Kirklin, Ulrich P Jorde, Daniel J Goldstein
BACKGROUND: Patients with restrictive (RCM) and hypertrophic (HCM) cardiomyopathies are felt to be a difficult population to treat with left ventricular assist device (LVAD) therapy. Scarce data exist on outcomes of continuous-flow (CF) LVAD support in these challenging patient cohorts. METHODS: The Interagency Registry for Mechanically Assisted Circulatory Support Registry was queried for all patients with RCM (n = 94) and HCM (n = 104) who underwent CF LVAD implantation between March 2008 and March 2014...
December 2017: Journal of Cardiac Failure
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