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Journal of Cardiac Failure

Eugene E Wolfel
No abstract text is available yet for this article.
September 14, 2018: Journal of Cardiac Failure
M Octavia Rangel, Robert Kaplan, Martha Daviglus, Neil Schneiderman, Barry E Hurwitz, Jianwen Cai, Franklyn Gonzalez, Dalane Kitzman, Mayank Kansal, Carlos J Rodriguez
No abstract text is available yet for this article.
September 14, 2018: Journal of Cardiac Failure
Whitney E Hornsby, Mohamed-Ali Sareini, Jessica R Golbus, Cristen J Willer, Jennifer L McNamara, Matthew C Konerman, Scott L Hummel
BACKGROUND: Frailty reflects decreased resilience to physiologic stressors; its prevalence and prognosis are not fully defined in heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS: The Short Physical Performance Battery (SPPB) was prospectively obtained in 114 outpatients with HFpEF. The SPPB tests gait speed, tandem balance, and timed chair rises, each scored 0-4 points. Severe and mild frailty were respectively defined as an SPPB score ≤6 and 7-9 points...
September 13, 2018: Journal of Cardiac Failure
Shunsuke Kuroda, Kevin Damman, Jozine M Ter Maaten, Adriaan A Voors, Takahiro Okumura, Keisuke Kida, Shogo Oishi, Eiichi Akiyama, Satoshi Suzuki, Masayoshi Yamamoto, Takeshi Kitai, Kazuki Yoshida, Akihiko Matsumura, Yuya Matsue
BACKGROUND: In hospitalized heart failure patients, a poor diuretic response (DR) during the first days of hospital admission is associated with worse outcomes. However, it remains unknown whether diuretic response in the first hours has similar prognostic value. Moreover, data on the sequential change in DR during hospital admission are lacking. METHODS AND RESULTS: DR (urine output per 40 mg furosemide-equivalent diuretics dose) was measured from 0 to 6 hours (DR6), 6 to 48 hours (DR6-48), and 0 to 48 hours (DR48) of the patient's arrival to the emergency department (ED) in 1551 patients with AHF (mean age 78 years old; 56% were male; and 48% were de-novo patients with heart failure)...
September 13, 2018: Journal of Cardiac Failure
Calum A MacRae
No abstract text is available yet for this article.
September 13, 2018: Journal of Cardiac Failure
Carine E Hamo, Christopher O'Connor, Marco Metra, James E Udelson, Mihai Gheorghiade, Javed Butler
The prevalence of heart failure continues to grow and this is accompanied by an increase in hospitalization for acute heart failure. Hospitalization for heart failure results in a trajectory shift of the syndrome and is associated with worsening outcomes, increased mortality risk, and high costs. Numerous clinical trials over the past two decades have had limited success with not a single agent shown to improve mortality risk. The lack of success is multifactorial and in part related to inadequate targets and endpoints selected for intervention, underscoring the need to better understand and define the pathophysiology of acute heart failure...
September 11, 2018: Journal of Cardiac Failure
Rengin Çetin Güvenç, Nurgül Ceran, Tolga Sinan Güvenç, Hacer Ceren Tokgöz, Yalçın Velibey
BACKGROUND: Involvement of right-sided heart chambers (RSHC) in patients infected with Human Immunodeficiency Virus (HIV) is common and is usually attributed to pulmonary arterial or venous hypertension. However, myocardial involvement in patients with HIV is also common and might affect RSHC even in the absence of overt pulmonary hypertension (PH). Our aim was to define morphologic and functional alterations in RSHC in patients with HIV and without pulmonary hypertension (PH). METHODS AND RESULTS: A total of 50 asymptomatic patients with HIV and 25 control subjects without clinical or echocardiographic signs for PH were included to the study...
September 6, 2018: Journal of Cardiac Failure
T Scott Bowen, Christian Herz, Natale P L Rolim, Anne-Marie Ormbostad Berre, Martin Halle, Angela Kricke, Axel Linke, Gustavo Justo da Silva, Ulrik Wisloff, Volker Adams
BACKGROUND: HFpEF is underpinned by detrimental skeletal muscle alterations that contribute to disease severity, yet underlying mechanisms and therapeutic treatments remain poorly established. This study used an animal model of HFpEF to better understand whether skeletal muscle abnormalities were: 1) fiber-type specific; and 2) reversible by various exercise training regimes. METHODS AND RESULTS: Lean controls were compared to obese ZSF1 rats at 20 weeks, and 8 weeks later following sedentary, high-intensity interval training, or moderate-continuous treadmill exercise...
September 6, 2018: Journal of Cardiac Failure
Kristin M Kostick, Courtenay R Bruce, Charles G Minard, Robert J Volk, Andrew Civitello, Selim R Krim, Douglas Horstmanshof, Vinay Thohan, Matthias Loebe, Hanna Mazen, Brian A Bruckner, J S Blumenthal-Barby, Jerry D Estep
BACKGROUND: Studies indicate that decision making and informed consent among patients considering Left Ventricular Assist Device (LVAD) support for advanced heart failure could be improved. In the VADDA (ventricular assist device decision aid) trial, we tested a patient-centered decision aid (DA) to enhance the quality of decision making about LVAD therapy. METHODS: After an extensive, user-centered design process we conducted a multi-site randomized trial of the DA compared to standard education (SE) among inpatients considering LVAD treatment for advanced heart failure The main outcome was LVAD Knowledge at 1-week and 1-month following administration of the DA versus SE, using a validated scale...
September 6, 2018: Journal of Cardiac Failure
Bárbara Pereira Fernandes, Lino Sergio Rocha Conceição, Paulo Ricardo Saquete Martins-Filho, Douglas Rafanelle Moura DE Santana Motta, Vitor Oliveira Carvalho
No abstract text is available yet for this article.
September 5, 2018: Journal of Cardiac Failure
Elias J Dayoub, Hema Datwani, Jennifer Lewey, Peter W Groeneveld
Background Peripartum cardiomyopathy (PPCM) is an important cause of obstetric morbidity. Few large, national studies have investigated the cardiovascular outcomes of women with PPCM, particularly beyond the immediate postpartum period. We examined the cardiovascular outcomes of one-year survivors of PPCM in a large, commercially-insured population. Methods and Results A retrospective cohort study was conducted using administrative claims from patients ages 15 to 54 years insured by a national commercial payer during 2005 to 2012...
September 4, 2018: Journal of Cardiac Failure
Sheila L Klassen, Robert J H Miller, Robin Hao, J Wayne Warnica, Nowell M Fine, Mahendra Carpen, Debra L Isaac
BACKGROUND: Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS: We performed an interrupted time-series cohort study of heart failure (HF) patients admitted to the Georgetown Public Hospital Corporation from January to December 2015 and July 2016 to December 2017...
August 16, 2018: Journal of Cardiac Failure
Bunny J Pozehl, Rita McGuire, Kathleen Duncan, Kevin Kupzyk, Joseph Norman, Nancy T Artinian, Pallav Deka, Steven K Krueger, Matthew A Saval, Steven J Keteyian
BACKGROUND: Few exercise training studies in patients with heart failure (HF) report adherence to guideline-recommended 150 minutes of moderate-intensity exercise per week, and no studies have focused on a primary outcome of adherence. METHODS AND RESULTS: This randomized controlled trial evaluated the effect of a multicomponent intervention, Heart Failure Exercise and Resistance Training (HEART) Camp, on adherence to exercise (after 6, 12, and 18 months) compared with an enhanced usual care (EUC) group...
August 16, 2018: Journal of Cardiac Failure
Shinya Tanaka, Kentaro Kamiya, Nobuaki Hamazaki, Ryota Matsuzawa, Kohei Nozaki, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Takashi Masuda, Junya Ako
BACKGROUND: The impact of frailty on long-term prognosis in patients with heart failure (HF) remains unclear, and there is no simple and objective assessment for it. This study was performed to examine the association between frailty score and clinical outcome in elderly patients hospitalized for HF. METHODS AND RESULTS: A retrospective cohort study was performed with 603 elderly patients with HF (mean age 75 ± 6 years, 378 [62.7%] men). Frailty was measured by a composite of 4 markers combined into a frailty score (possible range 0-12): gait speed, handgrip strength, serum albumin, and activities of daily living status...
August 16, 2018: Journal of Cardiac Failure
Paul Welsh, Olia Papacosta, Sheena Ramsay, Peter Whincup, John McMurray, Goya Wannamethee, Naveed Sattar
OBJECTIVE: The aim of this work was to study the association of high-sensitivity troponin T (hsTnT) with incident heart failure (HF), and implications for its use in prediction models. METHODS AND RESULTS: In the British Regional Heart Study, 3852 men aged 60-79years without baseline HF (3165 without baseline chronic heart disease) were followed for a median of 12.6years, during which 295 incident cases of HF occurred (7.7%). A 1-SD increase in log-transformed hsTnT was associated with a higher risk of incident HF after adjusting for classic risk factors (hazard ratio [HR] 1...
August 11, 2018: Journal of Cardiac Failure
C Hjalmarsson, J-A Liljeqvist, M Lindh, K Karason, E Bollano, A Oldfors, B Andersson
BACKGROUND: Parvovirus B19 (PVB19) has emerged as one of the viruses possibly inducing chronic myocarditis and subsequent IDCM. AIM: to investigate the presence and the long-term consequences of PVB19-DNA within myocardial biopsies in patients with IDCM and to compare the findings with those of donor hearts (control group). METHODS AND RESULTS: 40 hospitalized IDCM patients (age 47 ±12y) with LVEF 27 ±12% were included. The presence of PVB19-DNA in myocardial biopsies, and of IgG and IgM antibodies in patient sera was analysed...
August 10, 2018: Journal of Cardiac Failure
Erik H van Iterson, Joshua R Smith, Thomas P Olson
BACKGROUND: Peak exercise pulmonary oxygen uptake (V̇O2 ) is a primary marker of prognosis in heart failure (HF). The pathophysiology of impaired peak V̇O2 is unclear in patients. To what extent alveolar airway function affects V̇O2 during cardiopulmonary exercise testing (CPET) has not been fully elucidated. This study aimed to describe how changes in alveolar ventilation (V̇A ), volume (VA ), and related parameters couple with exercise V̇O2 in HF. METHODS AND RESULTS: A total of 35 patients with HF (left ventricular ejection fraction 20 ± 6%, age 53 ± 7 y) participated in CPET with breath-to-breath measurements of ventilation and gas exchange...
August 10, 2018: Journal of Cardiac Failure
Teruhiko Imamura, Gene Kim, Jayant Raikhelkar, Nitasha Sarswat, Sara Kalantari, Bryan Smith, Daniel Rodgers, Ben Chung, Ann Nguyen, Takeyoshi Ota, Tae Song, Colleen Juricek, Valluvan Jeevanandam, Daniel Burkhoff, Gabriel Sayer, Nir Uriel
BACKGROUND: Decoupling between diastolic pulmonary arterial pressure (dPAP) and pulmonary arterial wedge pressure (PAWP) is an index of pulmonary vasculature remodeling and provides prognostic information. Furthermore, decoupling may change during incremental left ventricular assist device (LVAD) speed changes. METHODS AND RESULTS: In this prospective study, patients underwent an echocardiographic and hemodynamic ramp test after LVAD implantation and were followed for 1 year...
August 10, 2018: Journal of Cardiac Failure
Louise Y Sun, Jack V Tu, Heather Sherrard, Norvinda Rodger, Thais Coutinho, Michele Turek, Elizabeth Chan, Heather Tulloch, Lisa McDonnell, Lisa M Mielniczuk
BACKGROUND: Differences in outcomes have previously been reported between urban and rural settings across a multitude of chronic diseases. Whether these discrepancies have changed over time, and how sex may influence these findings is unknown for patients with ambulatory heart failure (HF). We examined the temporal incidence and mortality trends by geography in these patients. METHODS AND RESULTS: We conducted a retrospective cohort study of 36,175 eastern Ontario residents who were diagnosed with HF in an outpatient setting from 1994 to 2013...
August 10, 2018: Journal of Cardiac Failure
Marco Metra, Nicolò Dasseni, Carlo Lombardi
No abstract text is available yet for this article.
August 9, 2018: Journal of Cardiac Failure
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