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Journal of Cardiac Failure

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https://www.readbyqxmd.com/read/28801077/myocardial-amyloid-quantification-with-look-locker-magnetic-resonance-sequence-in-cardiac-amyloidosis-diagnostic-accuracy-in-clinical-practice-and-histological-validation
#1
Eduardo Pozo, Jose M Castellano, Anubhav Kanwar, Rajiv Deochand, Mireia Castillo-Martin, Pablo Pazos-López, Carlos González-Lengua, Keren Osman, Matthew Cham, Carlos Cordon-Cardo, Jagat Narula, Valentin Fuster, Javier Sanz
BACKGROUND: Cardiac magnetic resonance (CMR) has demonstrated its utility in the non-invasive diagnosis of cardiac amyloidosis (CA). Our aim was to evaluate the ability of standard Look-Locker sequences to quantify amyloid deposition in CA. METHODS AND RESULTS: Consecutive patients referred for CMR for possible CA were retrospectively evaluated. Positive cardiac biopsy and/or typical pattern of late gadolinium enhancement were required for the diagnosis of CA. Post-contrast T1 values were obtained from Look-Locker sequences, and correlated with markers of severity of disease and major events...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801076/early-development-of-right-ventricular-ischemic-lesions-in-a-novel-large-animal-model-of-acute-right-heart-failure-in-chronic-thromboembolic-pulmonary-hypertension
#2
David Boulate, Jennifer Arthur Ataam, Andrew J Connolly, Genevieve Giraldeau, Myriam Amsallem, Benoit Decante, Lilia Lamrani, Elie Fadel, Peter Dorfmuller, Frederic Perros, Francois Haddad, Olaf Mercier
BACKGROUND: Our aim was to develop a model of acute right heart failure (ARHF) in the setting of pulmonary hypertension and to characterize acute right ventricular lesions that develop early after hemodynamic restoration. METHODS AND RESULTS: We used a described piglet model of chronic pulmonary hypertension (cPH) induced by pulmonary artery occlusions. We induced ARHF in animals with cPH (ARHF-cPH group, n=9) by volume loading and iterative acute pulmonary embolisms until hemodynamic compromise followed by dobutamine infusion for hemodynamic restoration prior to sacrifice for right ventricular tissue evaluation...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801075/doppler-assessment-of-diastolic-function-reflect-the-severity-of-injury-in-rats-with-chronic-heart-failure
#3
Pablo Sanchez, Jordan J Lancaster, Kyle Weigand, Saffie-Alrahman Ezz-Eldin Mohran, Steven Goldman, Elizabeth Juneman
OBJECTIVE: For chronic heart failure (CHF), more emphasis has been placed on evaluation of systolic as opposed to diastolic function. Within the study of diastology, measurements of left ventricular (LV) longitudinal myocardial relaxation have the most validation. Anterior wall radial myocardial tissue relaxation velocities along with mitral valve inflow (MVI) patterns are applicable diastolic parameters in the differentiation between moderate and severe disease in the ischemic rat model of CHF...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28801074/rational-heart-transplant-from-hepatitis-c-donor-new-antiviral-weapons-conquer-the-trojan
#4
Robert L Gottlieb, Teena Sam, Suzanne Y Wada, James F Trotter, Sumeet K Asrani, Brian Lima, Susan M Joseph, Gonzalo Gonzalez-Stawinski, Shelley A Hall
BACKGROUND: Donors with hepatitis C (HCV) viremia are rarely utilized for orthotopic heart transplantation (OHTx) due to post-transplant risks. New, highly effective HCV antivirals may alter the landscape. METHODS: An adult patient unsuitable for bridging mechanical support therapy accepted a heart transplant offer from a donor with HCV viremia. Upon daily logarithmic rise in HCV viral load and adequate titers to ensure successful genotyping, once daily sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa) was initiated empirically pending HCV genotype (genotype 3a confirmed after initiation of therapy)...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28797824/response-to-letter-to-the-editor-by-mr-john-renesch
#5
LETTER
Michael W Rich, Suzanne J Wingate
No abstract text is available yet for this article.
August 7, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28797823/a-patient-s-plea-please%C3%A2-stop-calling-it-heart-failure
#6
LETTER
John Renesch
No abstract text is available yet for this article.
August 7, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28782596/scientific-program
#7
(no author information available yet)
No abstract text is available yet for this article.
August 3, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28760644/why-has-a-run-in-period-been-a-design-element-in-most-landmark-clinical-trials-analysis-of-the-critical-role-of-run-in-periods-in-drug-development
#8
Milton Packer
Prior exposure to one of the randomized treatments has been a routine design element of large-scale trials in patients at high cardiovascular risk. A run-in feature has allowed our trials to be more realistic; it has strengthened their ability to estimate the true treatment effect, and it has never undermined the validity of a trial's findings. Those who suggest that run-in periods distort the results of large-scale trials should become more familiar with our history of drug development and our standards of clinical practice...
July 28, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28757151/run-in-periods-in-randomized-clinical-trials
#9
EDITORIAL
Kenneth B Schechtman
No abstract text is available yet for this article.
July 28, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28757153/hemodynamic-determinants-of-the-biological-variation-of-nt-probnp-in-patients-with-stable-systolic-chronic-heart-failure
#10
Tobias Täger, Ann-Kathrin Wiedergruen, Hanna Fröhlich, Rita Cebola, Anna Corletto, Andrea Horsch, Georg Hess, Karen Slottje, Dietmar Zdunek, Hugo A Katus, Frank H Wians, Lutz Frankenstein
BACKGROUND: Biological variation of amino-terminal probrain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) may affect blood levels and risk stratification. The sources of NT-proBNP variation are unknown. METHODS AND RESULTS: We performed NT-proBNP measurements, clinical and hemodynamic assessment in 50 patients with HFrEF who met criteria for clinical stability at 2 time intervals. Hemodynamic variables were measured using inert gas rebreathing and impedance cardiography...
July 27, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28757152/where-patients-with-heart-failure-die-trends-in-location-of-death-of-patients-with-heart-failure-in-the-united-states
#11
LETTER
Sadeer G Al-Kindi, Christine Koniaris, Guilherme H Oliveira, Monique R Robinson
No abstract text is available yet for this article.
July 27, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28757150/temporal-differences-in-outcomes-during-long-term-mechanical-circulatory-support
#12
Simon Maltais, Lucman A Anwer, Nicholas A Haglund, Jennifer Cowger, Palak Shah, Keith D Aaronson, Francis D Pagani, Shannon M Dunlay, Ramesh Singh, Christopher T Salerno, John M Stulak
BACKGROUND: Device indications have changed for placement of continuous-flow left ventricular assist devices (CF-LVADs). We performed a multicenter analysis evaluating temporal variations in outcomes after CF-LVAD implantation. METHODS & RESULTS: We retrospectively defined three time intervals to reflect changes in CF-LVAD technology (Period 1: 2004 to 2009; Period 2: 2010 to 2012; and Period 3: 2012 to 2014). A total of 1,064 patients (HeartMate II (HMII)=835, HeartWare (HVAD)=229) underwent CF-LVAD implantation between May 2004 and October 2014...
July 27, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28739205/editor-s-page-henry-and-mount-rushmore
#13
EDITORIAL
Paul J Hauptman
No abstract text is available yet for this article.
July 21, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28736291/clinical-and-hemodynamic-correlates-and-prognostic-value-of-ve-vco2-slope-in-patients-with-heart-failure-with-preserved-ejection-fraction-and-pulmonary-hypertension
#14
Sebastiaan H C Klaassen, Licette C Y Liu, Yoran M Hummel, Kevin Damman, P van der Meer, Adriaan A Voors, Elke S Hoendermis, Dirk J van Veldhuisen
BACKGROUND: Impaired exercise capacity is one of the hallmarks of heart failure with preserved ejection fraction (HFpEF), but the clinical and hemodynamic correlates and prognostic value of exercise testing in patients with HFpEF is unknown. METHODS: Patients with HFpEF (Left ventricular ejection fraction [LVEF] ≥ 45%) and pulmonary hypertension, underwent cardiopulmonary exercise test (CPX) to measure maximal (peak VO2) and sub maximal (ventilatory equivalent for carbon dioxide [VE/VCO2] slope) exercise capacity...
July 20, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28716688/influence-of-thoracic-fluid-compartments-on-pulmonary-congestion-in-chronic-heart-failure
#15
Steven C Chase, Bryan J Taylor, Troy J Cross, Kirsten E Coffman, Lyle J Olson, Bruce D Johnson
INTRODUCTION: Pulmonary congestion is a common finding of heart failure (HF), but it remains unclear how pulmonary and heart blood volumes (Vp and Vh) and extravascular lung water (EVLW) change in stable HF and impact lung function. METHODS: Fourteen patients with HF (age: 68±11 y; LVEF: 33±8%) and 12 controls (age: 65±9 y) were recruited. A pulmonary function test, thoracic CT scan, and contrast perfusion scan were performed. From the thoracic scan, a histogram of CT attenuation of lung tissue was generated and skew, kurtosis, and full-width half-max were calculated as surrogates of EVLW...
July 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28716687/measures-of-ventricular-arterial-coupling-and-incident-heart-failure-with-preserved-ejection-fraction-a-matched-case-control-analysis
#16
Carolyn L Lekavich, Debra J Barksdale, Jia-Rong Wu, Virginia Neelon, Jamie Crandell, Eric J Velazquez
BACKGROUND: Evidence continues to demonstrate increasing prevalence, cost, and mortality implications of heart failure with preserved ejection fraction (HFpEF), but clearly defined parameters that distinguish between control subjects and HFpEF have not been established. OBJECTIVES: This study was designed to detect differences in markers associated with Ventricular-arterial coupling and HFpEF when comparing matched case and control groups. METHODS: A study cohort of case (incident patients with HFpEF; n = 155) and matched control (patients with no prior heart failure; n = 155) groups was retrospectively identified...
July 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28712955/clinical-impact-of-changes-in-hemodynamic-indices-of-contractile-function-during-treatment-of-acute-decompensated-heart-failure
#17
Kenneth C Bilchick, Eliany Mejia-Lopez, Peter McCullough, Khadijah Breathett, Jamie L Kennedy, Jose Tallaj, James Bergin, Salpy Pamboukian, Mohammad Abuannadi, Sula Mazimba
BACKGROUND: The objective was to determine the impact of improving right ventricular versus left ventricular stroke work indices (RVSWI v. LVSWI) during therapy for acute decompensated heart failure (ADHF). METHODS AND RESULTS: Cox proportional hazards regression and logistic regression was used to analyze key factors associated with outcomes in 175 patients (age 56.7 ± 13.6 years, 29.1% female) with hemodynamic data from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial...
July 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28712954/social-media-platforms-and-heart-failure
#18
R Jay Widmer, Makala K Arce, Lee A Aase, Farris K Timimi
With the pervasive use of the internet and social media, the potential applicability toward patients with heart failure (HF) remains understudied. Here, we outline the general use of social media and some early work with the use of social media as well as data from our own Mayo Clinic Center for Social Media experience. Both enterprise-wide social media data as well as those specific to HF-related pages and posts appear to support the preferential use of Facebook and Youtube for potential benefit in patients with HF...
July 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28689765/unanswered-questions-in-contemporary-heart-failure
#19
Lauren G Gilstrap, David Snipelisky, Omar AbouEzzeddine, Justin Vader, Lauren Cooper, Jacob Kelley, Antonio Perez, Kenneth Varian, Anuradha Lala, Monica Shah, Lynne W Stevenson
Background The epidemiology of heart failure (HF) is changing. This study aims to describe questions that arise during the routine care of heart failure (HF) patients that are unanswered by the current literature and describe how the type and focus of these questions has changed over time. Methods Investigators from the NHLBI-sponsored Heart Failure Apprentice Network collected and categorized questions from 5 academic hospitals over 12 months. A total of 174 unanswered questions were collected and analyzed...
July 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28688889/increased-secondary-primary-bile-acid-ratio-in-chronic-heart-failure
#20
Cristiane C K Mayerhofer, Thor Ueland, Kaspar Broch, Royce P Vincent, Gemma F Cross, Christen P Dahl, Pål Aukrust, Lars Gullestad, Johannes R Hov, Marius Trøseid
OBJECTIVE: Bile acids (BAs) are now recognized as signaling molecules and emerging evidence suggests that BAs affect cardiovascular function. The gut microbiota has recently been linked to the severity of heart failure (HF), and microbial metabolism has a major impact on BA homeostasis. We aimed to investigate the pattern of BAs, and particularly microbiota-transformed (secondary) BAs, in patients with chronic HF. METHODS AND RESULTS: This was a prospective, observational, single-center study including 142 patients with chronic HF and 20 age- and sex-matched healthy control subjects...
July 5, 2017: Journal of Cardiac Failure
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