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Journal of Cardiac Failure

Bryce N Balmain, Surendran Sabapathy, Ollie Jay, Julie Adsett, Glenn M Stewart, Rohan Jayasinghe, Norman R Morris
Upon heat exposure, the thermoregulatory system evokes reflex increases in sweating and skin blood flow responses to facilitate heat dissipation and maintain heat balance to prevent the continuing rise in core temperature. These heat dissipating responses are mediated primarily by autonomic and cardiovascular adjustments; which if attenuated, may compromise thermoregulatory control. In patients with heart failure (HF), the neurohumoral and cardiovascular dysfunction that underpins this condition may potentially impair thermoregulatory responses and, consequently, place these patients at a greater risk of heat-related illness...
April 10, 2017: Journal of Cardiac Failure
Jaroslav Meluzin, Zdenek Starek, Tomas Kulik, Jiri Jez, Frantisek Lehar, Jiri Wolf, Ladislav Dusek, Pavel Leinveber, Miroslav Novak
BACKGROUND: Patients with atrial fibrillation (AF) have an increased risk of diastolic dysfunction and heart failure. The purpose of this study was to identify independent predictors of early (i.e., only exercise-induced) heart failure with preserved ejection fraction (HFpEF) and to describe the prevalence of early HFpEF among the patients with paroxysmal AF. METHODS AND RESULTS: One hundred patients with paroxysmal AF and preserved left ventricular ejection fraction (LVEF) underwent catheterization with left atrial pressure (LAP) measurements at rest and at the peak of arm exercise (LAP-exe)...
April 10, 2017: Journal of Cardiac Failure
Olga Laszczyńska, Milton Severo, Fernando Friões, Patrícia Lourenço, Sérgio Silva, Paulo Bettencourt, Nuno Lunet, Ana Azevedo
BACKGROUND: -High diuretic doses in chronic heart failure (HF) are potentially deleterious. We assessed the effect of dynamic furosemide dose on all-cause mortality among HF ambulatory patients. METHODS AND RESULTS: -A cohort of 560 ambulatory patients from an outpatient clinic specialized in HF, with median age 70 years, 67% male, 89% with moderate-severely reduced ejection fraction, was retrospectively followed for up to 5 years. Dynamic furosamide exposure was categorized as low (0-59 mg/d), medium (60-119 mg/d), high (120-159 mg/d) and very high (≥160 mg/d)...
April 5, 2017: Journal of Cardiac Failure
Burhan Mohamedali, Rami Doukky, Kelly Karavalos, Elizabeth Avery, Geetha Bhat
BACKGROUND: Early right ventricular failure (RVF) is common after left ventricular assist device (LVAD) implantation and often leads to increased morbidity and mortality. It is difficult to predict early RVF on the basis of clinical and hemodynamic parameters. We investigated the utility of mean arterial pressure (MAP) to central venous pressure (CVP) ratio in predicting early RVF. METHOD: We analyzed a retrospective cohort of 212 consecutive patients who underwent hemodynamic assessment prior to destination therapy LVAD implantation...
March 29, 2017: Journal of Cardiac Failure
Daniel D Matlock, Jacqueline Jones, Carolyn T Nowels, Amy Jenkins, Larry A Allen, Jean S Kutner
BACKGROUND: Prior studies have demonstrated that patients with primary prevention implantable cardioverter-defibrillators (ICD) often misunderstand the ICD. Advances in behavioral economics demonstrate that some misunderstandings may be due to cognitive biases. We aimed to explore the influence of cognitive bias on ICD decision making. METHODS AND RESULTS: We used a qualitative framework analysis including 9 cognitive biases: affect heuristic, affective forecasting, anchoring, availability, default effects, halo effects, optimism bias, framing effects, and state dependence...
March 28, 2017: Journal of Cardiac Failure
Lars H Lund
No abstract text is available yet for this article.
March 23, 2017: Journal of Cardiac Failure
Bernadet T Santema, Carolyn S P Lam
No abstract text is available yet for this article.
March 22, 2017: Journal of Cardiac Failure
Berhe W Sahle, Alice J Owen, Ken Lee Chin, Christopher M Reid
BACKGROUND: Numerous models predicting the risk of incident heart failure (HF) have been developed, however evidence of their methodological rigour and reporting remains unclear. This study critically appraises the methods underpinning incident HF risk prediction models. METHODS AND RESULTS: EMBASE and PubMed were searched for articles published between 1990 and June 2016 that reported at least one multivariable model for prediction of HF. Model development information, including study design, variable coding, missing data, and predictor selection, was extracted...
March 21, 2017: Journal of Cardiac Failure
Hans Persson
No abstract text is available yet for this article.
March 20, 2017: Journal of Cardiac Failure
M Linschoten, A J Teske, A F Baas, A Vink, D Dooijes, H F Baars, F W Asselbergs
Chemotherapy-induced cardiomyopathy (CCMP) is a complication of chemotherapy treatment occurring in 9% of patients treated with anthracyclines. Currently, risk stratification is based on clinical risk factors that do not adequately explain the variable individual susceptibility. This points towards the presence of other determinants. In this case series, we describe two women with breast cancer that developed severe heart failure within months after chemotherapy. Genetic screening revealed truncating frameshift mutations in TTN, encoding the myofilament titin, in both women...
March 14, 2017: Journal of Cardiac Failure
Luer Bao, Qingshu Meng, Yuan Li, Shengqiong Deng, Zuoren Yu, Zhongmin Liu, Lin Zhang, Huimin Fan
BACKGROUND: Stem cell transplantation offers a promising treatment for heart failure. Recent studies show that both c-kit positive cardiac stem cells (CSCs) and bone marrow-derived mesenchymal stem cells (BM-MSCs) are good candidates for stem cell therapy to treat heart failure. However, the exact mechanism of stem cell therapy in improving cardiac function of ischemic cardiomyopathy is not fully known. Our objective was to test our hypothesis that CSCs and/or BM-MSCs repair the damaged heart by boosting post-myocardial infarction (MI) angiogenesis in a paracrine manner...
March 8, 2017: Journal of Cardiac Failure
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Philippe P B Bertrand, Matthias Dupont, Wilson W H Tang, Wilfried Mullens
BACKGROUND: Cardiac resynchronization therapy (CRT) improves mortality and morbidity on top of optimal medical therapy in heart failure with reduced ejection fraction (HFrEF). This study aimed to elucidate the association between neurohumoral blocker up-titration after CRT implantation and clinical outcomes. METHODS AND RESULTS: Doses of angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs), and beta-blockers were retrospectively evaluated in 650 consecutive CRT patients implanted from October 2008 to August 2015 and followed in a tertiary multidisciplinary CRT clinic...
March 8, 2017: Journal of Cardiac Failure
April Stempien-Otero, Stephen Farris
No abstract text is available yet for this article.
February 21, 2017: Journal of Cardiac Failure
Paul J Hauptman
No abstract text is available yet for this article.
February 20, 2017: Journal of Cardiac Failure
Ali Mehdirad, Charles Love
No abstract text is available yet for this article.
February 17, 2017: Journal of Cardiac Failure
Linda G Park, David W Schopfer, Ning Zhang, Hui Shen, Mary A Whooley
BACKGROUND: Cardiac rehabilitation (CR) is linked to reduced mortality and morbidity, including improvements in cardiorespiratory fitness, psychosocial state, and quality of life in patients with heart failure (HF). However, little is known about CR utilization among patients with HF. OBJECTIVE: We sought to determine (a) the proportion of patients with HF who participated in CR and (b) patient characteristics associated with participation. METHODS: A retrospective study was conducted with the use of national data from the Centers for Medicare and Medicaid Services and the Veterans Health Administration...
February 14, 2017: Journal of Cardiac Failure
Michael E Nassif, Timothy J Fendler, John A Spertus
No abstract text is available yet for this article.
February 14, 2017: Journal of Cardiac Failure
Nasser Davarzani, Sandra Sanders-van Wijk, Joël Karel, Micha T Maeder, Gregor Leibundgut, Marc Gutmann, Matthias E Pfisterer, Peter Rickenbacher, Ralf Peeters, Hans-Peter Brunner-la Rocca
BACKGROUND: Although heart failure (HF) patients are known to experience repeated hospitalizations, most studies evaluated only time to first event. N-Terminal B-type natriuretic peptide (NT-proBNP)-guided therapy has not convincingly been shown to improve HF-specific outcomes, and effects on recurrent all-cause hospitalization are uncertain. Therefore, we investigated the effect of NT-proBNP-guided therapy on recurrent events in HF with the use of a time-between-events approach in a hypothesis-generating analysis...
February 13, 2017: Journal of Cardiac Failure
Dilek Ural, Aysen Şimşek Kandemir, Kurtuluş Karaüzüm, Canan Baydemir, İrem Yılmaz Karaüzüm, Serdar Bozyel, Güliz Kozdağ, Ayşen Ağaçdiken Ağır
BACKGROUND: Hydralazine-nitrate combination is recommended for patients with heart failure with reduced ejection fraction (HFrEF)/systolic heart failure who are symptomatic despite guideline-directed medical therapy (GDMT). Use of nitrates alone for this indication is not well-established. This study aims to evaluate the effect of oral nitrates on all-cause mortality and hospitalization in HFrEF patients using GDMT. METHODS AND RESULTS: Nitrate prescription at discharge and its association with all-cause mortality and heart failure hospitalization were examined in a propensity-matched analysis of 648 HFrEF patients followed for a median of 56 months...
April 2017: Journal of Cardiac Failure
Kathleen C Woulfe, Austine K Siomos, Hieu Nguyen, Megan SooHoo, Csaba Galambos, Brian L Stauffer, Carmen Sucharov, Shelley Miyamoto
BACKGROUND: Although fibrosis seems to be prognostic for adverse outcomes in adults with idiopathic dilated cardiomyopathy (IDC), little is known about the prevalence and development of fibrosis in pediatric IDC hearts. We hypothesized that there is less activation of fibrosis at a molecular level in pediatric IDC hearts than in failing adult hearts. METHODS AND RESULTS: Pediatric hearts were analyzed histologically to determine the prevalence of fibrosis. Left ventricular tissue from adult and pediatric IDC hearts and adult and pediatric nonfailing (NF) hearts were subjected to quantitative reverse-transcription polymerase chain reaction to study the expression of important mRNAs that affect fibrosis...
April 2017: Journal of Cardiac Failure
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