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Journal of Cardiac Failure

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https://www.readbyqxmd.com/read/30448455/effects-of-weight-loss-in-outpatients-with-mild-chronic-heart-failure-findings-from-the-j-melodic-study
#1
Yoshitaka Okuhara, Masanori Asakura, Yoshiyuki Orihara, Yoshiro Naito, Takeshi Tsujino, Masaharu Ishihara, Tohru Masuyama
BACKGROUND: Weight loss is a strong prognostic factor in chronic heart failure (CHF); however, little is known about its effects in patients with mild CHF. Therefore, we investigated the effects of weight loss in patients with mild CHF. METHODS AND RESULTS: We analyzed a total of 242 outpatients with mild CHF from J-MELODIC study cohort. Weight loss was defined as ≥5% weight loss at 1 year. Twenty-seven (11.2%) patients lost ≥5% weight in 1 year. Patients with weight loss was associated with higher rate of underweight and worsening renal function in 1 year compared with those without ≥5% weight loss...
November 15, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30439566/lower-extremity-function-as-a-marker-of-frailty-and-outcomes-of-heart-failure-with-preserved-ejection-fraction-in-older-adults
#2
Dae Hyun Kim, Sandra M Shi
No abstract text is available yet for this article.
November 12, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30423457/heart-failure-epidemiology-in-patients-with-diabetes-mellitus-without-coronary-heart-disease
#3
Hassan Khan, Stefan D Anker, James L Januzzi, Darren K McGuire, Naveed Sattar, Hans Juergen Woerle, Javed Butler
BACKGROUND: Epidemiology of patients with comorbid heart failure (HF) and diabetes mellitus (DM) without coronary heart disease (CHD) is not well described. METHODS AND RESULTS: We assessed HF incidence and outcomes in 2,896 participants of the Health ABC Study (age 74.0±3.0 years, 48.4% men, 41.1% black, 34.6% DM) in relation to prior DM and CHD status. During a median follow-up of 11.4 years, 484 (16.7%) participants developed incident HF; 214 (44.2%) had DM of whom 71 (33...
November 10, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30415014/improvement-in-biventricular-cardiac-function-following-ambulatory-counterpulsation
#4
Teruhiko Imamura, Colleen Juricek, Tae Song, Takeyoshi Ota, David Onsager, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Sara Kalantari, Gabriel Sayer, Daniel Burkhoff, Valluvan Jeevanandam, Nir Uriel
BACKGROUND: The NuPulseCV intravascular ventricular assist system (iVAS), which consists of a durable pump placed through the subclavian artery, provides extended duration ambulatory counterpulsation. This study investigated the effect of iVAS on biventricular cardiac function. METHODS AND RESULTS: We reviewed all heart failure patients who received iVAS implantation as a bridge to transplantation or a bridge to candidacy since April 2016 as part of the iVAS first-in-human and subsequent Feasibility study...
November 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30415013/use-of-heart-failure-exacerbating-medications-among-adults-with-heart-failure
#5
LETTER
Jerard Kneifati-Hayek, Peter Kennel, Joanna Bryan, Monika M Safford, Parag Goyal
No abstract text is available yet for this article.
November 8, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30412734/incidence-predictors-and-outcomes-of-new-onset-left-ventricular-systolic-dysfunction-after-orthotopic-liver-transplantation
#6
Dr Vaughn A Eyvazian, Jonathan S Gordin, Eric H Yang, Olcay Aksoy, Henry M Honda, Ronald W Busuttil, Vatche G Agopian, Gabriel Vorobiof
BACKGROUND: Adverse cardiovascular events after liver transplant (LT) are relatively common and are a significant source of early mortality. Although new onset systolic dysfunction after LT is a reported phenomenon, there is little data regarding its incidence, risk factors, and outcomes. METHODS: This single center, retrospective study from January 2002 to March 2015 included all adult patients with deceased donor LT and available pre-operative transthoracic echocardiogram (TTE)...
November 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30366054/pulmonary-artery-wedge-pressure-at-rest-and-during-exercise-in-healthy-adults-a-systematic-review-and-meta-analysis
#7
Sam Esfandiari, Emil Wolsk, David Granton, Lucas Azevedo, Felipe Homem Valle, Finn Gustafsson, Susanna Mak
BACKGROUND: The pulmonary artery wedge pressure (PAWP) response to exercise may unmask latent heart failure with preserved ejection fraction. There remains a lack of consensus over threshold values for PAWP during exercise. A systematic review of studies examining PAWP by right heart catheterization at rest and during exercise in healthy individuals was performed. METHODS AND RESULTS: Relevant data derived from healthy volunteers were stratified by age (> or ≤40 years) and sex...
October 23, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30359689/heart-failure-etiologies-and-challenges-to-care-in-the-developing-world-an-observational-study-in-the-democratic-republic-of-congo
#8
Didier Malamba-Lez, Dophra Ngoy-Nkulu, Paul Steels, Désiré Tshala-Katumbay, Wilfried Mullens
BACKGROUND: Limited data are available with regards to etiology and outcome of heart failure as well as organization of care in the developing world. METHODS: We included consecutive patients diagnosed with heart failure between November 2014 and September 2016 in a university and private hospital of Lubumbashi, Democratic Republic Congo. Baseline data including echocardiography were analyzed to determine factors associated with mortality. Cost of hospitalization as well as challenges for care with regards to follow-up were determined...
October 22, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30347272/hydrogen-and-methane-based-breath-testing-and-outcomes-in-patients-with-heart-failure
#9
Anna Mollar, Maria Pilar Villanueva, Eduardo NÚÑez, Arturo CarratalÁ, Francisco Mora, Antoni BayÉs-GenÍs, Miguel MÍnguez, Vannina G Marrachelli, Daniel Monleon, David Navarro, Juan Sanchis, Julio NÚÑez
BACKGROUND: Recent evidence endorses gut microbiota dysregulation in the pathophysiology of heart failure (HF). Small intestinal bacterial overgrowth (SIBO) might be present in HF and associated with poor clinical outcomes. Lactulose breath testing is a simple noninvasive test that has been advocated as a reliable indicator of SIBO. In patients with HF, we aimed to evaluate the association with clinical outcomes of the exhaled hydrogen (H2 ) and methane (CH4 ) concentrations through the lactulose breath test...
October 19, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30347271/a-novel-paradigm-for-sacubitril-valsartan-beta-endorphin-elevation-as-a-contributor-to-exercise-tolerance-improvement-in-rats-with-preexisting-heart-failure-induced-by-pressure-overload
#10
M Y Maslov, S Foianini, M V Orlov, J L Januzzi, M A Lovich
BACKGROUND: Simultaneous angiotensin receptor (AT1 ) blockade and neprilysin inhibition with sacubitril/valsartan has been recently approved to treat patients with heart failure (HF). Therapeutic benefits of this therapy have been attributed to natriuretic peptide elevation and AT1 receptor blockade. However, this pharmacologic picture may not be complete. The aims of this study were to investigate the pharmacology of sacubitril/valsartan in comparison to monotherapies with sacubitril, and valsartan, and to examine their impact on peptides upregulated by neprilysin inhibition, such as beta-endorphin...
October 19, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30342903/failure-to-develop-new-therapies-in-ahf-is-it-time-to-de-focus-from-congestion
#11
Gad Cotter, Beth A Davison
No abstract text is available yet for this article.
October 18, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30339796/low-utilization-of-beta-blockers-among-medicare-beneficiaries-hospitalized-for-heart-failure-with-reduced-ejection-fraction
#12
Matthew Shane Loop, Melissa K Van Dyke, Ligong Chen, Monika M Safford, Meredith L Kilgore, Todd M Brown, Raegan W Durant, Emily B Levitan
BACKGROUND: The evidence-based beta-blockers carvedilol, bisoprolol, and metoprolol succinate reduce mortality and hospitalizations among patients with heart failure with reduced ejection fraction (HFrEF). Use of these medications is not well described in the general population of patients with HFrEF, especially among patients with potential contraindications. OBJECTIVES: Our goal was to describe the patterns of prescription fills for carvedilol, bisoprolol, and metoprolol succinate among Medicare beneficiaries hospitalized for HFrEF, as well as to estimate the associations between specific contraindications for beta-blocker therapy and those patterns...
October 16, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30336199/heart-failure-and-suicide-the-role-of-depression
#13
Christopher M Celano, Jeff C Huffman
No abstract text is available yet for this article.
October 15, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30312764/understanding-the-etiology-of-heart-failure-among-the-rural-poor-in-sub-saharan-africa-a-10-year-experience-from-district-hospitals-in-rwanda
#14
Lauren A Eberly, Emmanuel Rusingiza, Paul H Park, Gedeon Ngoga, Symaque Dusabeyezu, Francis Mutabazi, Emmanuel Harerimana, Joseph Mucumbitsi, Philippe F Nyembo, Ryan Borg, Cyprien Gahamanyi, Cadet Mutumbira, Evariste Ntaganda, Christian Rusangwa, Gene F Kwan, Gene Bukhman
BACKGROUND: Heart failure is a significant cause of morbidity and mortality in sub-Saharan Africa. Our understanding of the heart failure burden in this region has been limited mainly to registries from urban referral centers. Starting in 2006, a nurse-driven strategy was initiated to provide echocardiography and decentralized heart failure care within noncommunicable disease (NCD) clinics in rural district hospitals in Rwanda. METHODS: We conducted a retrospective review of patients with cardiologist-confirmed heart failure treated at 3 district hospital NCD clinics in Rwanda from 2006 to 2017 to determine patient clinical characteristics and disease distribution RESULTS: Over 10 years, 719 patients with confirmed heart failure were identified...
October 9, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30308241/a-novel-simple-diagnostic-algorithm-for-rapid-and-accurate-detection-of-anemia-etiology-in-patients-with-advanced-heart-failure
#15
LETTER
Elisabeth Kaldara, Konstantinos Malliaras, Despina Barbarousi, Chris J Kapelios, Stella Vakrou, Ioannis Tachliabouris, John N Nanas
No abstract text is available yet for this article.
October 9, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30300685/the-crossroads-of-frailty-and-heart-failure-what-more-can-we-learn
#16
EDITORIAL
Quin E Denfeld, Christopher S Lee
No abstract text is available yet for this article.
October 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30300684/resting-heart-rate-and-chronotropic-response-to-exercise-prognostic-implications-in-heart-failure-across-left-ventricular-ejection-fraction-spectrum
#17
Mário Santos, Erin West, Hicham Skali, Daniel E Forman, Wilson Nadruz, Amil M Shah
BACKGROUND: We studied the relationship between resting HR, chronotropic response to exercise, and clinical outcomes in patients with HF across the spectrum of left ventricle ejection fraction (LVEF). METHODS: Resting HR and chronotropic index (CIx) were assessed in 718 patients with HF (53±14 years, 66% male) referred for exercise testing. Associations with the composite outcome of LVAD implantation, transplantation, or death (151 events; 4.4 [3.0-5.8] years of follow-up) were assessed by Cox models adjusted for age, sex, HF etiology, diabetes, LVEF, beta-blocker use, device therapy, eGFR and peak VO2 ...
October 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30296584/biochemical-determinants-of-changes-in-plasma-volume-after-decongestion-therapy-for-worsening-heart-failure
#18
Hajime Kataoka
BACKGROUND: Optimal vascular volume is required to avoid organ dysfunction during decongestive therapy for worsening heart failure (HF). This study investigated the relation between changes in serum substance(s) and the vascular volume after diuresis in HF patients. METHODS AND RESULTS: Data from 47 patients with HF undergoing conventional diuretic therapy were analyzed. Blood tests included measurements of hemoglobin, hematocrit, and serum albumin/solutes. The relative changes in the plasma volume (%PV) from worsening HF to recovery were determined with the use of the Strauss formula...
October 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30296583/heart-failure-differentially-modulates-the-effects-of-ivabradine-on-the-electrical-activity-of-the-sinoatrial-node-and-pulmonary-veins
#19
Chao-Shun Chan, Yao-Chang Chen, Shih-Lin Chang, Yung-Kuo Lin, Yu-Hsun Kao, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Ivabradine increases the risk of atrial fibrillation (AF). Heart failure (HF) or sinoatrial node (SAN) dysfunction increases the risk of AF, and pulmonary veins (PVs) play a critical role in the pathophysiology of AF. This study investigated the electrophysiologic effects of ivabradine on SANs and PVs in a rabbit model of HF. METHODS AND RESULTS: Conventional microelectrodes were used to simultaneously record the electrical activities and conduction properties of control and HF rabbit SAN-PV preparations before and after perfusion with ivabradine (0...
October 6, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30296582/first-hospitalization-for-heart-failure-in-outpatients-with-stable-coronary-artery-disease-determinants-role-of-incident-myocardial-infarction-and-prognosis
#20
Nicolas Lamblin, Thibaud Meurice, Olivier Tricot, Pascal de Groote, Gilles Lemesle, Christophe Bauters
BACKGROUND: We lack recent data on the incidence, correlates, and prognosis associated with heart failure (HF) development in patients with stable coronary artery disease (CAD). Here, we analyzed HF development in a contemporary population of outpatients with stable CAD. METHODS AND RESULTS: Of 4184 unselected outpatients with stable CAD (i.e., myocardial infarction [MI] and/or coronary revascularization >1 year prior) included in the multicenter CORONOR registry, we identified 3871 patients with no history of hospitalization for HF at inclusion, and followed 3785 (98%) for 5 years...
October 5, 2018: Journal of Cardiac Failure
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