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Protein and Peptide Letters

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https://www.readbyqxmd.com/read/29984641/molecular-aspects-of-the-dengue-virus-infection-process-a-review
#1
Luiz Fernando Da Costa Zonetti, Milena Conceicao Coutinho, Alexandre Suman de Araujo
At the present time, dengue is one of the most important arboviruses affecting man, becoming a serious global public health problem, especially in subtropical and tropical countries, where environmental conditions favor the development and proliferation of the mosquito Aedes aegypti. Dengue is caused by a type of flavivírus, which is an enveloped virus of spherical geometry. Nowadays, it is one of the diseases with the highest incidence in Brazil, reaching the population of all states, regardless of social class...
July 8, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29972101/transglycosylation-activity-of-catalytic-domain-mutant-of-endo-1-3-%C3%AE-glucanase-from-cellulosimicrobium-cellulans
#2
Yoshiji Hantani, Shoko Motoki, Atsushi Miyagawa, Hatsuo Yamamura, Masayuki Oda
A mutation of catalytic residue, Glu119 to Gly, in endo-1,3-β-glucanase from Cellulosimicrobium cellulans DK-1 generates the mutant enzyme (E119G) with decreased hydrolytic activity and which exhibits transglycosylation activity on laminarioligosaccharides. Transglycosylation activity was not observed in the case of laminaribiose as a substrate, probably owing to the lower binding affinity of E119G to laminaribiose than to large laminarioligosaccharides. Notably, the combination of laminaribiose and laminaritriose as a substrate enhanced the transglycosylation activity of E119G...
July 3, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29956608/hyaluronidases-a-therapeutic-enzyme
#3
Naqab Khan, Zahid Rasul Niazi, Fazlur Rehman, Anam Akhtar, Maryam Muhammad Khan, Samiullah Khan, Sheraz Khan
BACKGROUND: Hyaluronidase is the most important enzyme found in the interstitial matrix, effectively degrading the hyaluronic acid. Hyaluronidases are extensively found in the venom of various animals such as snake, scorpion, spider and others. Up till now five venom hyaluronidases are identified with a defined three-dimensional structure. These enzymes are involved in different biochemical, physiological and pathological conditions like degradation of hyaluronic acid, embryogenesis, transmembrane diffusion of drugs and toxins, inflammatory and allergic response to antigens, healing of wounds, bacterial meningitis, bacteremia and pneumonia...
June 29, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29956607/phosphodiesterases-pdes-from-snake-venoms-therapeutic-applications
#4
Bushra Uzair, Barkat Ali Khan, Nourin Sharif, Fouzia Shabbir, Farid Menaa
BACKGROUND: Snake venom, a highly poisonous and active venomous snake's secretion, is a complex mixture of inorganic cations, carbohydrates, lipids, proteins, peptides, toxins and hydrolytic enzymes of importance including Phosphodiesterases (PDEs). These snake venom hydrolytic enzymes interfere in different physiological processes. Snake venom PDEs have several roles to metabolize extracellular nucleotides and to regulate nucleotide based intercellular signalling mechanisms including platelet aggregation, which can lead to death and debilitation in cardiac arrest and strokes in patients having cerebro-vascular and cardiovascular diseases, hypertension and atherosclerosis which is the primary cause of life-threatening diseases such as, stroke and myocardial-infarction...
June 28, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29956606/potential-uses-of-venom-proteins-in-treatment-of-hiv
#5
Bushra Uzair, Rabia Bushra, Barkat Ali Khan, Sarwat Zareen, Fehmida Fasim
BACKGROUND: For about 30 years Human Immunodeficiency Virus (HIV) has been a significant social and health issue. It has been a perilous opponent in the human contest against HIV. At the end of 2015 there were 26.7 million people worldwide who were affected by the Human Immunodeficiency Virus (HIV) and this number is expected to increase. Unfortunately, currently there are no vaccines available for prevention and control of HIV. The global burden of HIV articulates the need for anti-HIV therapeutic factors...
June 28, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29956605/subtle-changes-due-to-mutations-in-the-ggdef-domain-result-in-loss-of-biofilm-forming-activity-in-the-vc0395_0300-protein-from-vibrio-cholerae-but-no-major-change-in-the-overall-structure
#6
Sumit Biswas, Om Prakash Chouhan
Cyclic-di-GMP (c-di-GMP) is a ubiquitous secondary messenger molecule in bacteria synthesized by diguanylate cyclases. This universal messenger regulates diverse cellular functions in bacteria at the transcriptional, translational and posttranslational levels. The cellular functions regulated by c-di-GMP include cell motility, cell cycle progression, virulence, biofilm formation, antibiotic production and other unknown functions. The VC0395_0300 protein from the chromosome I of the Vibrio cholerae classical strain O395, serotype O1 has been established to be a diguanylate cyclase with a necessary role in biofilm formation...
June 28, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29929460/search-for-functional-flexible-regions-in-the-g-protein-family-new-reading-of-the-foldunfold-program
#7
Oxana Galzitskaya, Eugenia Deryusheva, Andrey Machulin, Ekaterina Nemashkalova, Anna Glyakina
High prediction accuracy of flexible loops in different protein families is a challenge because of the crucial functions associated with these regions. Results of the currently available programs for prediction of loops vary from protein to protein. For prediction of flexible regions in the G-domain for 23 representatives of G-proteins with the known 3D structure we have used eight programs. The results of predictions demonstrate that the FoldUnfold program predicts better loop positions than the PONDR, RОNN, DisEMBL, IUPred, GlobPlot 2, FoldIndex, and MobiDB programs...
June 21, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29929458/purification-and-characterization-of-an-extracellular-t2-family-ribonuclease-rnase-from-bacillus-megaterium-nrrl-3712
#8
Fatima Akram, Ikram Ul Haq, Zahid Hussain, Sana Rashid
Ribonucleases of T2 family are ubiquitous cellular components which have played several biological functions in molecular and pharmaceutical fields. Therefore, a soluble and highly active RNase belonging to T2 family was screened from Bacillus megaterium NRRL 3712. Various cultivation strategies were applied to enhance the production of RNase and bacterial cell density. A monomeric enzyme with a molecular mass of 45 kDa, was purified to homogeneity using acetone precipitation and ion-exchange chromatography...
June 21, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29929459/crystal-structure-analysis-of-great-cormorant-phalacrocorax-carbo-hemoglobin
#9
Jagadeesan Ganapathy, Malathy Palayam, Gautam Pennathur, Aravindhan Sanmargam, Gunasekaran Krishnasamy
BACKGROUND: Hemoglobin (Hb) molecule consists of α2β2 dimers arranged in fashion having pseudo-222 symmetry. The subunits are composed of the specific functional prosthetic group "heme'' and a protein moiety "globin". Bird Hbs are functionally similar to mammalian Hbs and regulated by inositol pentaphosphate (IPP) but they are structurally dissimilar with mammalian Hbs in adaptation to vital environment such as high altitudes, high speed flights and oxygen affinity. The insufficient structural studies on avian Hbs limit us to understand their degree of adaptation to such critical environments...
June 20, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921197/venom-protein-c-activators-as-diagnostic-agents-for-defects-of-protein-c-system
#10
Faiqah Ramzan, Andleeb Asmat
Background Protein C is a vitamin K dependent plasma zymogen. It prevents clotting by inhibiting clotting by inactivating factor V and factor VIII. Protein C activation pathway involves three steps: (i) Activation of protein C; (ii) Inhibition of coagulation through inactivating factor V and VIII by activated protein C and (iii) Inhibition of activated protein C by plasma protease inhibitors specific for this enzyme. Proteinases converts the zymogen Protein C (PC) of vertebrates into activated PC, which has been detected in several snake venoms...
June 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921195/simulation-studies-and-dynamic-interaction-of-venom-peptides-with-ion-channels
#11
Naqab Khan, Zahid Rasul Niazi, Nauman Rahim Khan, Kifayatullah Shah, Khurram Rehman, Abdula Wahab, Samiullah Khan
BACKGROUND: Arthropods such as scorpion, snake, insects, and spider as well as the marine animals like sea anemone and cone snails are venomous animals producing venoms with a complex mixture of peptide, poly peptides and small proteins. The disulfide rich peptides isolated from these animals are potent substances which specifically and selectively modulate different ion channels. The significant characteristics of these distinctive pharmacologically potent compounds highlights the molecular details of their peptide-ion channels interactions as well as provides the opportunities for the development of novel and natural therapeutic agents to treat various diseases including neurological disorders also...
June 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921193/potential-application-of-venom-proteins-in-designing-of-medicines-for-treating-human-neurodegenerative-disorders
#12
Zahid Rasul Niazi, Naqab Khan, Samiullah Khan, Mehboob Alam, Mohammad A Kamal
BACKGROUND: Neurodegenerative disorder are persistently increasing and relentlessly affecting the individuals, families and society as whole. Regrettably these disorders are resistant to the available drugs, the outcomes are only palliative while the side effects of the therapy harm the patient compliance as well as treatment. Drugs from venomous source have been considered as an effective alternative for such types of disorders, particularly neurodegenerative diseases. Due to emerging advancement in the field of proteomics, genomics and molecular biology, characterization and screening of these novel compounds become more assessable...
June 14, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921199/applications-of-venom-proteins-as-potential-anticancer-agents
#13
Samina Ejaz, Fatima Bashir Hashmi, Waqas Nazir Malik, Muhammad Ashraf, Faiz Ul-Hassan Nasim, Muhammad Iqbal
BACKGROUND: Venoms, the secretions of venomous animals, are conventionally thought to be the source of toxic substances though the views about venoms in the recent era have been changed. Venoms are the proven source of many biologically and pharmacologically important useful molecules. Bioactive components present in different venoms are mainly proteins and peptides either enzymatic or non-enzymatic which have tremendous therapeutic potential and are being used for the treatment of variety of diseases including cancer...
June 13, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921198/potential-applications-of-venom-peptides-as-anti-thrombotic-agents-for-management-of-arterial-and-deep-vein-thrombosis
#14
Samiullah Khan, Aqsa Gul, Rabia Noreen, Muhammad Ashraf, Sohail Ahmad, Sattar Bakhsh Awan, Zahid Rasool Niazi, Naqab Khan
BACKGROUND: Thrombus is composed of two main substances i.e. red blood cells and aggregated platelets which make a web of inter-connected fibrin proteins. During injury it prevents bleeding, so it is very useful but it can be very dangerous if it is produced in healthy blood vessels and block the blood flow through it. Mural thrombi attaches with the blood vessels but in most cases do not block it completely. Venoms are an incredible source of peptides having amazing bioactivities with varying number of amino acid residues...
June 13, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921196/snake-venom-as-an-effective-tool-against-colorectal-cancer
#15
Bushra Uzair, Nagina Atlas, Sidra Batool Malik, Nazia Jamil, Temitope Ojuolape Salaam, Mujaddad Ur Rehman, Barkat Ali Khan
BACKGROUND: Cancer is considered one of the most predominant causes of morbidity and mortality all over the world and colorectal cancer is the most common fatal cancers, triggering the second cancer related death. Despite progress in understanding carcinogenesis and development in chemotherapeutics, there is an essential need to search for improved treatment. More than the half a century, cytotoxic and cytostatic agents have been examined as a potential treatment of cancer, among these agents; remarkable progresses have been reported by the use of the snake venom...
June 13, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29921194/scorpion-venom-peptides-as-a-potential-source-for-human-drug-candidates
#16
Bushra Uzair, Sarah Bint-E-Irshad, Barkat Ali Khan, Beenish Azad, Tariq Mahmood, Mujaddad Ur Rehman, Valdir A Braga
BACKGROUND: Scorpion venom is the most expensive and deadly venom with exciting medical prospects and having a potential as a source of drug candidates. A number of scorpion venom peptides have shown promising site specificity and are involved in the regulation of biological mechanisms. Due to the structural and functional specificity, the scorpion peptides are widely used for the development of specific drugs especially for the cardiovascular and other immune diseases. In this review, we summarize scorpion venom's biological activities such as antimicrobial, antiviral, anti-cancerous and in immune diseases...
June 13, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29848262/the-effect-of-culture-temperature-on-the-aggregation-of-recombinant-tnfr-fc-is-regulated-by-the-perk-eif2a-pathway-in-cho-cells
#17
Kai Wang, Tu Zhang, Jing Chen, Chen Xuexuan Liu, Jie Tang, Qiuling Xie
Recombinant human tumor necrosis factor receptor II-Fc (TNFR-Fc) is a therapeutic protein expressed in Chinese hamster ovary (CHO) cells. The desired TNFR-Fc is a dimer; however, aggregates are often formed during culture and need to be removed to minimize the risk of immunogenicity to patients. Lower temperatures improve recombinant protein production in CHO cells. Here, we investigated the effect of different culture temperatures (37°C and 31°C, or a shift from 37°C to 31°C on the 3rd day) on the aggregation of recombinant TNFR-Fc...
May 30, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29848261/a-comparison-between-cell-protein-and-peptide-based-approaches-for-selection-of-nanobodies-against-cd44-from-a-synthetic-library
#18
Soudabeh Kavousipour, Pooneh Mokarram, Seyed Latif Mousavi Gargari, Zohreh Mostafavi-Pour, Mehdi Barazesh, Amin Ramezani, Hassan Ashktorab, Shiva Mohammadi, Saeid Ghavami
The hyaluronic acid receptor CD44, is a cancer stem cell biomarker, playing important roles in cell adhesion, tumor progression and drug-resistance. Therefore, CD44 is a potential target for cancer treatment and its blockade could result in multi-factorial therapeutic effects. Nanobodies against CD44 were isolated from a synthetic library with a diversity of 5×1011 CFU/ml using the phage display technique. Three approaches were used for isolation of nanobodies fragments including peptide-, protein- and cell-based panning...
May 30, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29848260/optimization-of-protein-and-peptide-drugs-based-on-the-mechanisms-of-kidney-clearance
#19
Jiaguo Huang, Huizi Wu
Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides has been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times, which limits the application for their clinical use. In most cases a short half-life time is not effective to deliver sufficient amount of drugs to the target organs and tissues, which is generally caused by fast renal clearance and low plasma stability due to proteolytic degradation during systemic circulation, because the most common clearance pathway of small proteins and peptides is through glomerular filtration by the kidneys...
May 30, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29848259/peptide-and-low-molecular-weight-proteins-based-kidney-targeted-drug-delivery-systems
#20
Pengfei Xu, Hailiang Zhang, Ruili Dang, Pei Jiang
Renal disease is a worldwide public health problem, and unfortunately, the therapeutic index of regular drugs is limited. Thus, it is a great need to develop effective treatment strategies. Among the reported strategies, kidney-targeted drug delivery system is a promising method to increase renal efficacy and reduce extra-renal toxicity. In recent years, working as vehicles for targeted drug delivery, low molecular weight proteins (LMWP) and peptide have received immense attention due to their many advantages, such as selective accumulation in kidney, high drug loading capability, control over routes of biodegradation, convenience in modification at the amino terminus, and good biocompatibility...
May 30, 2018: Protein and Peptide Letters
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