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Türk Patoloji Dergisi

Deniz Arik, Funda Canaz, Emine Dündar
Oncocytic tumors are rare in the adrenal gland. The histopathological diagnosis of adrenocortical carcinoma is difficult due to the lack of precise diagnostic criteria for malignancy. A 44-year-old man was admitted to our hospital with left flank pain. Radiologically an adrenal mass was detected. After the excision and histopathologic evaluation of the mass, a diagnosis of adrenocortical oncocytic carcinoma was made. At least one of the features of more than 5 mitoses in 50 high power fields, atypical mitotic figures or venous invasion is required for the diagnosis of malignancy in adrenocortical tumors...
2016: Türk Patoloji Dergisi
Ruchi Srivastava, Neelam Wadhwa, Shikha Gupta, Urvashi Razdan
The nose is an uncommon site for head and neck paraganglioma. The diagnosis is seldom established pre-operatively; its rarity, infrequent functionality and often benign biologic outcome underlie this fact. We present one such case in a 60-year-old man who presented with right nasal obstruction and episodic epistaxis. Rhinoscopy revealed a fleshy polypoid mass arising from the anterior cartilaginous nasal septum. Imaging studies excluded extra-nasal extension. The tumor was highly vascular showing numerous variable sized, mostly thin walled branching blood vessels akin to stag-horn shape simulating a vascular neoplasm...
2016: Türk Patoloji Dergisi
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
Mohamed Mokhtar Desouki, Ihab Shafek Atta, Daynna J Wolff, Sally E Self
OBJECTIVE: In the current work, we compared HER2 by fluorescence in situ hybridization and estrogen and progesterone receptors by immunohistochemistry in matched primary breast carcinomas and their lymph node metastases. MATERIAL AND METHOD: Thirty-nine cases of primary and lymph node metastases were assessed for HER2. Primary tumors of the cases selected were known to be HER2 negative. Also, immunohistochemistry for estrogen and progesterone receptors was performed on 36 cases from the same cohort to assess any discrepancy between the primary tumor and the lymph node metastases...
2016: Türk Patoloji Dergisi
Zeynep Tosuner, Zühal Gücin, Tuğçe Kiran, Nur Büyükpinarbaşili, Seval Turna, Olcay Taşkiran, Dilek Sema Arici
OBJECTIVE: A major target of quality assurance is the minimization of error rates in order to enhance patient safety. Six Sigma is a method targeting zero error (3.4 errors per million events) used in industry. The five main principles of Six Sigma are defining, measuring, analysis, improvement and control. Using this methodology, the causes of errors can be examined and process improvement strategies can be identified. The aim of our study was to evaluate the utility of Six Sigma methodology in error reduction in our pathology laboratory...
2016: Türk Patoloji Dergisi
Ebru Şener, Sare Şipal, Cemal Gündoğdu
OBJECTIVE: Angiogenesis plays a key role in tumor growth and metastasis. Determination of microvessel density is the most common technique used to evaluate the amount of the intratumoral angiogenesis in breast cancer. We have aimed to investigate the relationship with tumor angiogenesis and prognostic parameters in breast invasive ductal carcinomas. MATERIAL AND METHOD: In this study, a total of 100 invasive ductal carcinoma patients, who were diagnosed at the Department of Pathology, Ataturk University Faculty of Medicine between the years 2003-2008, were re-evaluated...
2016: Türk Patoloji Dergisi
Senem Ersavaş, Gülden Diniz, Hülya Tosun Yildirim, Yetkin Koca, Dudu Solakoğlu Kahraman, Duygu Ayaz, Bengü Demirağ
OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) and Kidney injury molecule-1 (KIM-1) play important roles in both immunity and cell proliferation. It was reported previously that they are overexpressed in various human cancers. The present study was undertaken to examine the expressions of NGAL and KIM-1 in Wilms Tumors. MATERIAL AND METHOD: Tissue samples of 50 Wilms Tumors were evaluated and underwent immunhistochemical staining for NGAL and KIM-1 protein expressions...
2016: Türk Patoloji Dergisi
Cherry Bansal, Mukta Pujani, Sanjeev Misra, A N Srivastava, U S Singh
OBJECTIVE: Circulating tumor cells are isolated tumor cells in the peripheral blood that serve as important prognostic indicators for many kind of tumors. The study was conducted to know the rate of detection of circulating tumor cells among breast cancer patients in comparison with benign breast diseases and control subjects and to know the association between CTC positivity and various clinicopathological parameters, hormonal profile and microRNA polymorphisms. MATERIAL AND METHOD: In the present case control study, we included 182 healthy controls, 108 cases of benign breast disease and 114 breast carcinoma cases...
2016: Türk Patoloji Dergisi
Tuba Canpolat, Canan Ersöz, Aysun Uğuz, Mehmet Ali Vardar, Aytekin Altintaş
OBJECTIVE: Malignant cells show increased glucose uptake in in vitro and in vivo studies. This uptake is mediated by glucose transporter proteins. GLUT-1 is the most common transporter protein, and its expression is reported to be increase in many human cancers. The aim of this study is to determine the GLUT-1 overexpression in benign, hyperplastic, and malignant endometrial tissues, to evaluate the usefulness of GLUT-1 expression in endometrial hyperplasia, and to determine its role in the neoplastic progression to endometrioid type adenocarcinoma...
2016: Türk Patoloji Dergisi
Gülden Diniz, Yasemin Baskin, Gizem Çalibaşi, Safiye Aktaş
No abstract text is available yet for this article.
2016: Türk Patoloji Dergisi
Meetu Agrawal, Tara Roshni Paul, Shantveer G Uppin, Sundaram Challa
Carcinosarcomas of the lung are uncommon neoplasms and are presently categorized along with sarcomatoid carcinomas in the WHO 2004 classification. Morphological recognition of individual components in a surgical specimen is usually straightforward. The respiratory epithelium is also a rare site for salivary gland type tumors. A 72-year-old lady who was investigated for an episode of hemoptysis was found to have a well circumscribed intraluminal tumor. The histo-morphological features were unique and composed of mucoepidermoid carcinoma and undifferentiated sarcoma...
2016: Türk Patoloji Dergisi
Divya Pursnani, Swati Arora, Palur Katyayani, Ambica C, Balasaheb Ramling Yelikar
OBJECTIVE: Proper identification of surgical margins along with margin status holds utmost importance in histopathology. Inking margins is one way. India ink has long been used but it can ink only one margin. On other hand acrylic colours, available in variety of colours can be used for inking multiple margins along with many more advantages. The present study was undertaken to analyse acrylic colours and Indian ink for inking surgical margins via three different methods for optimum results...
2016: Türk Patoloji Dergisi
Smeeta Gajendra, Rashi Sharma, Shalini Goel, Ruchika Goel, Lipika Lipi, Hemanti Sarin, Mridula Guleria, Ritesh Sachdev
OBJECTIVE: Histoplasmosis is an infectious disease caused by the dimorphic fungus Histoplasma capsulatum, endemic in central and eastern states of United States, South America and Africa. India is considered to be non-endemic area for histoplasmosis. Disseminated histoplasmosis may affect almost all systems. Disseminated histoplasmosis with asymptomatic adrenal involvement has been described in immunocompromised patients; whereas isolated adrenal involvement with adrenal insufficiency as the presenting manifestation of the disease is rare...
2016: Türk Patoloji Dergisi
Sümeyye Ekmekci, Nur Olgun, Erdener Özer
OBJECTIVE: Prognostic parameters in determining risk groups for treatment in neuroblastoma are cellular differentiation, mitosis karyorrhexis index (MKI), N-myc amplification and age. However, additional prognosticators are still needed because patients can show unpredictable biological behavior. We aimed to study the prognostic significance of apoptotic activity in neuroblastomas. MATERIAL AND METHOD: Thirty-five primary neuroblastoma were evaluated. The data including stage, treatment protocol, metastatic disease, survival, N-myc status, age and prognostic categorization were obtained from the clinical records...
2016: Türk Patoloji Dergisi
Supriya Jain, Vijaya Basavaraj, Manjunath Gubbanna Vimala
OBJECTIVE: Sub-epidermal bullous disorders belong to immunobullous diseases which develop as a result of autoantibody action against epidermal basement membrane proteins. Clinically, they are tense bullae and do not rupture easily. They are classified into various forms based on histopathology and direct immunofluorescence patterns. This study was undertaken to assess the incidence of various sub-epidermal bullous disorders and the utility of direct immunofluorescence in accurately classifying them, and to study the intensity and pattern of immunofluorescence in various sub-epidermal bullous disorders Material and Method: A 2-year study of 38 cases of sub-epidermal bullous disorders sent for direct immunofluorescence studies formed the study group...
2016: Türk Patoloji Dergisi
Burçin Pehlivanoğlu, Başak Doğanavşargil, Murat Sezak, İlke Nalbantoğlu, Metin Korkmaz
OBJECTIVE: Gastrointestinal parasitosis is a significant cause of morbidity and mortality. Definitive diagnosis is usually made by stool tests and/or serology but may require tissue evaluation. Although pathologists are usually familiar with common parasites, it is not well established whether the diagnosis could be suspected without seeing the "parasite" itself. MATERIAL AND METHOD: Resection or biopsy specimens of 32 cases with Giardia intestinalis (n=20), Enterobius vermicularis (n=5), Entamoeba histolytica (n=4), Fasciola hepatica (n=1), Strongyloides spp...
2016: Türk Patoloji Dergisi
Shimaa Ahmed, Hayam Rashed, Abdelmonem Hegazy, Abdel Motaleb Mohamed, Wael Elmesallamy
OBJECTIVE: Tumor stem cells have been found in a variety of neoplasms and stated to have a role in tumor progression. This study aimed to evaluate the prognostic significance of biomarkers which are said to be related to these cells, i.e., EZH2, ALDH1 and Ki-67, and their correlation with each other in astrocytic gliomas. MATERIAL AND METHOD: Formalin-fixed, paraffin-embedded tissue specimens of 40 patients with astrocytic glioma who underwent initial surgery during the period from December 2011 to May 2014 at Zagazig University Hospitals were enrolled in the study...
2016: Türk Patoloji Dergisi
Gürdeniz Serin, Gonca Karabulut, Yasemin Kabasakal, Gülşen Kandiloğlu, Taner Akalin
OBJECTIVE: Minor salivary gland biopsy is one of the objective tests used in the diagnosis of Sjögren syndrome. The aim of our study was to compare the clinical and laboratory data of primary and secondary Sjögren syndrome cases with a lymphocyte score 3 and 4 in the minor salivary gland biopsy. MATERIAL AND METHOD: Data from a total of 2346 consecutive minor salivary gland biopsies were retrospectively evaluated in this study. Clinical and autoantibody characteristics of 367 cases with lymphocyte score 3 or 4 and diagnosed with primary or secondary Sjögren syndrome were compared...
2016: Türk Patoloji Dergisi
Francesco Piscioli, Teresa Pusiol, Luca Roncati
No abstract text is available yet for this article.
2016: Türk Patoloji Dergisi
Gülsüm Özlem Elpek, Betül Ünal, Cumhur İbrahim Başsorgun, Erdem Ayik
No abstract text is available yet for this article.
2016: Türk Patoloji Dergisi
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