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Türk Patoloji Dergisi

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https://www.readbyqxmd.com/read/28984348/acute-myeloid-leukaemia-with-gene-mutation-a-correlation-with-haematological-and-immunophenotypic-characteristics-and-our-experience-in-a-tertiary-care-cancer-center-in-south-india
#1
Rachna Khera, Faiq Ahmed, Manasi Mundada, Lavanya Nambaru, Sudha S Murthy, Sandhya Devig, Senthil J Rajappa, Krishna Mohan Mallavarapu, A Santa, Pavan Kumar
OBJECTIVE: Molecular genetic analysis of FLT3, NPM1, and CEBPA is already the standard of care in patients with acute myeloid leukaemia (AML) and represents the most frequent genetic alterations and important diagnostic and prognostic indicators. This study was undertaken to determine the frequency of FLT3 and NPM1 gene mutations in our institution and to characterize the association between gene mutations and haematological parameters as well as immunophenotypic features. MATERIAL AND METHOD: Morphological, haematological and immunophenotypic characteristics of NPM1 and FLT3 mutations in 126 patients of de novo AML including adults and children were studied...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984347/tumorous-conditions-of-the-hand-a-retrospective-review-of-402-cases
#2
Ali Cavit, Haluk Özcanli, Mesut Sançmiş, Güzide Ayşe Ocak, Elif İnanç Gürer
OBJECTIVE: Knowledge concerning treatment and care of hand lesions is often based on small case series, case reports and a few large general case series. The aim of this study is to present our experience with hand tumors' and tumor-like lesions' incidence, age range and localizations. MATERIAL AND METHOD: Between 2006-2016, 402 patients operated and histopathologically diagnosed with bone and soft tissue tumorous conditions of the hand were evaluated retrospectively...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984346/do-the-well-known-prognostic-parameters-in-pancreatic-ductal-adenocarcinoma-really-reflect-survival
#3
Sonay Kuş Öztürk, Esra Erden
OBJECTIVE: Pancreatic ductal adenocarcinoma is an aggressive tumor with short survival. In this study we aimed to investigate the effect of well-known prognostic parameters on survival in these tumors. MATERIAL AND METHOD: A total of 56 pancreatic ductal adenocarcinoma cases diagnosed between 2005 and 2014 were included in the study. Survival data were obtained and histopathological parameters were re-evaluated in each patient. RESULTS: Tumor size (p=0...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984345/changes-in-the-hematopoietic-system-and-blood-under-the-influence-of-heavy-metal-salts-can-be-reduced-with-vitamin-e
#4
Anatolii Romaniuk, Mykola Lyndin, Yulia Lуndіna, Vladyslav Sikora, Natalia Hrintsova, Olena Timakova, Olena Gudymenko, Oksana Gladchenko
OBJECTIVE: The aim of our work was to study the blood parameters and bone marrow morphological changes in rats exposed to increased amounts of heavy metal salts and the effect of vitamin E. MATERIAL AND METHOD: Investigation of bone marrow structural features and blood parameters was performed in sexually mature Wistar male rats (n=84). RESULTS: Exposure to increased amounts of heavy metal salts led to the inhibition of erythropoiesis and leukopoiesis, as well as a synchronized increase in the number of megakaryocytes which was clearly reflected in the blood: the number of erythrocytes, leukocytes and Hb decreased, and the number of platelets increased...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984344/concomitant-intraocular-retinoblastoma-and-choroidal-hemangioma-in-a-1-year-old-boy
#5
Yacoub A Yousef, Maysa Al-Hussaini, Fareed H Barakat, Alaa Saleh, Mona Mohammad, Rasha Deebajah
We report a case of concomitant choroidal hemangioma in an eye that harbored intraocular retinoblastoma (RB) in a 1-year-old child. A 12-month-old boy presented with right white pupil (Leukocoria). The initial clinical diagnosis was unilateral intraocular RB Group C. The eye was treated initially by systemic chemotherapy combined with focal consolidation therapy followed by I-125 plaque radiotherapy. Massive sub-retinal recurrence was seen 4 months later, and Magnetic Resonance Imaging (MRI) showed extra-scleral invasion of the tumor, and therefore enucleation was performed...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984343/the-world-health-organization-classification-of-odontogenic-lesions-a-summary-of-the-changes-of-the-2017-4th-edition
#6
Merva Soluk-Tekkeşin, John M Wright
The 4 < sup > th < /sup > edition of the World Health Organization (WHO) Classification of Head and Neck Tumors was published in January 2017. The edition serves to provide an updated classification scheme, and extended genetic and molecular data that are useful as diagnostic tools for the lesions of the head and neck region. This review focuses on the most current update of odontogenic cysts and tumors based on the 2017 WHO edition. The updated classification has some important differences from the 3 < sup > rd < /sup > edition (2005), including a new classification of odontogenic cysts, 'reclassified' odontogenic tumors, and some new entities...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984342/follicular-dendritic-cell-sarcoma-of-the-larynx-apropos-a-rare-case-with-review-of-the-literature
#7
Ayushi Sahay, Munita Bal, Asawari Patil, Shubhada Kane, Prathamesh Pai
Extranodal follicular dendritic cell sarcomas are extremely rare neoplasms included under the hematolymphoid and dendritic group of neoplasms. Histologically, fascicular, whorled spindle cells with sprinkled lymphocytes are typical; however higher grade epithelioid morphology seen in a subset makes diagnosis of follicular dendritic cell sarcoma challenging. Rarity of occurrence, a wide histologic spectrum and a long list of differential diagnostic entities render follicular dendritic cell sarcoma an under-recognized entity susceptible to diagnostic pitfalls...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984341/immunohistochemical-analysis-of-the-extrinsic-apoptosis-process-in-the-non-neoplastic-and-neoplastic-prostate
#8
Ayşe Burcu Ileri, Reşit Doğan Köseoğlu, Fatma Markoç, İlker Etikan, Doğan Atilgan, Faik Alev Deresoy
OBJECTIVE: Deviations in the apoptotic process have been demonstrated in prostate carcinogenesis. We aimed to evaluate especially the process of extrinsic apoptosis in the spectrum of neoplastic lesions of the prostate epithelium so as to reveal the variations in the apoptotic process. MATERIAL AND METHOD: The study included 20 benign prostatic hyperplasia, 8 high-grade prostatic intraepithelial neoplasia and 82 prostatic carcinoma patients. Immunohistochemistry was performed on sections obtained from materials of suprapubic prostatectomy, tru-cut biopsy, transurethral resection and radical prostatectomy...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984340/water-clear-cell-adenoma-of-the-mediastinal-parathyroid-gland
#9
Deniz Arik, Emine Dündar, Evrim Yilmaz, Cumhur Sivrikoz
Water-clear cell adenoma of the parathyroid gland is a rare neoplasm that consists of cells with abundant clear-pink cytoplasm. There have only been 19 cases reported in the English literature. Here we report a case of water-clear cell adenoma of the mediastinal parathyroid gland. A 70-year-old male patient presented to the hospital with back pain and a mediastinal mass 6 cm in size was detected. After excision and microscopic evaluation, uniform, large clear cells with fine cytoplasmic vacuolization, without nuclear atypia, and arranged in solid and acinar patterns were revealed...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984339/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#10
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984338/synchronous-cervical-minimal-deviation-adenocarcinoma-gastric-type-adenocarcinoma-and-lobular-endocervical-glandular-hyperplasia-along-with-stil-in-peutz-jeghers-syndrome-eliciting-oncogenesis-pathways
#11
Azfar Neyaz, Nuzhat Husain, Manish Deodhar, Rohini Khurana, Saumya Shukla, Aditi Arora
We describe an unusual case of a Peutz-Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor "lobular endocervical glandular hyperplasia (LEGH)", "minimal deviation adenocarcinoma (MDA)" and "gastric-type adenocarcinoma (GTA)" along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. A 24-year-old woman presented with a white mucoid discharge and bleeding per vaginum for one year. Histopathological evaluation showed MDA & GTA in FIGO grade III with pelvic lymph node metastasis despite a deceptively bland tumour morphology and low Ki-67 index, indicating an aggressive tumour course and poor prognosis...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984337/primary-splenic-pregnancy-a-rare-but-imperative-cause-of-hemoperitoneum-case-report-and-review-of-literature
#12
Ruchi Rathore, Shilpi Shilpi, Ratna Chopra, Namrata Nargotra
Primary splenic pregnancy is an extremely rare form of extratubal ectopic pregnancy. These cases often cause splenic rupture in very early course of their gestation thereby presenting with hemoperitoneum in emergencies. Owing to the higher risk of exsanguination and death caused by hemoperitoneum, it is essential to diagnose these cases for proper management and better prognosis of the patients. We present the case of a 23-year-old female, gravida 2, para 1, live issue 1 presenting to the emergency outpatient department with acute abdomen and hemoperitoneum...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28984336/a-retrospective-evaluation-of-the-epithelial-changes-lesions-and-neoplasms-of-the-gallbladder-in-turkey-and-a-review-of-the-existing-sampling-methods-a-multicentre-study
#13
Güldal Esendağlı, F Göknur Akarca, Serdar Balcı, Asuman Argon, Selma Şengiz Erhan, Nesrin Turhan, Neslihan İnce Zengin, Sevinç Hallaç Keser, Betül Çelik, Tangül Bulut, Samir Abdullazade, Esra Erden, Berna Savaş, Temmuz Bostan, Özgül Sağol, Anıl Aysal Ağalar, Nuray Kepil, Yıldırım Karslıoğlu, Armağan Günal, Fatma Markoç, Burcu Saka, Gonca Özgün, Şükrü Oğuz Özdamar, Burak Bahadır, Esin Kaymaz, Emre Işık, Semin Ayhan, Deniz Tunçel, Banu Özgüven Yılmaz, Sevinç Çelik, Tuba Karabacak, İpek Erbarut Seven, Çiğdem Ataizi Çelikel, Zuhal Gücin, Özgür Ekinci, Gülen Akyol
OBJECTIVE: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. MATERIAL AND METHOD: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272688/can-cutting-needle-biopsy-be-an-alternative-to-excisional-biopsy-in-lymph-node-pathologies
#14
Aydan Kiliçarslan, Mehmet Doğan, Nuran Süngü, Emre Karakök, Leman Karabekmez, Mesut Akyol, Hayriye Tatli Doğan
OBJECTIVE: We aimed to compare cutting-needle biopsy (CNB) diagnoses with excisional biopsy diagnoses of enlarging lymph nodes and to determine the diagnostic value of CNB. MATERIAL AND METHOD: Out of the 291 cases that underwent CNB from lymph nodes between 2010 and 2016, 60 were included in the study in which pathological lymph nodes were excised after CNB. Demographic information, pathology and imaging reports, the diameters of the lymph nodes and the length of the CNBs of these cases were obtained from the hospital registry system...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272687/prognostic-value-of-twist-1-e-cadherin-and-ezh2-in-prostate-cancer-an-immunohistochemical-study
#15
Aziza E Abdelrahman, Shimaa A Arafa, Ragab A Ahmed
OBJECTIVE: There is an urgent need to identify molecular biomarkers rather than clinical markers to distinguish aggressive prostate cancer from the indolent majority for proper treatment and accurate prediction of prognosis. We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMT)-related molecules (Twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272686/ambiguous-genitalia-associated-with-an-extremely-rare-syndrome-a-case-report-of-xlag-syndrome-and-review-of-the-literature
#16
Brijnandan Gupta, Prashant Ramteke, V K Paul, Tarun Kumar, Prasenjit DAS
X-linked lissencephaly, absent corpus callosum, and epilepsy of neonatal onset with ambiguous genitalia comprises the XLAG syndrome and only 15 cases have been reported in literature. Due to its rarity, the exact clinical course and outcome are not known. Exact associations of this disease are also elusive. Hereby we are reporting this extremely rare entity and we searched the English literature extensively to get consolidated knowledge regarding this entity that would help the readers. Pre-natal radiological work-up can detect these malformations, which should be followed by medical termination, counseling and karyotyping...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272685/therapy-induced-neural-differentiation-in-ewing-s-sarcoma-a-case-report-and-review-of-the-literature
#17
Kıvılcım Eren Erdoğan, Mehmet Ali Deveci, Zeynep Ruken Hakkoymaz, Gülfiliz Gönlüşen
Ewing's sarcoma (ES) is a small round cell tumor of adolescents or young adults that usually arises in the deep soft tissues of the extremities. The tumor cells have uniform round nuclei, fine powdery chromatin and indistinct nucleoli. CD99 (O13) is a product of the MIC 2 gene that is highly sensitive to ES but not specific. A panel of markers should be used for the differential diagnosis of small round cell tumors because nearly all others, on occasion, show membranous staining for CD99. One of the defining feature of ES is the presence of 22q12 gene rearrangement...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272684/intraductal-neoplasms-of-the-pancreas-an-update
#18
Gökçe Aşkan, Pelin Bağci, Bahar Memiş, Olca Baştürk
With improvements in imaging to detect silent pancreatic lesions and increases in the number of centers now performing pancreatic surgery, more surgeries have been performed for indications other than invasive carcinoma. This has enormously added to our knowledge of the intraductal neoplasms of the pancreas. In addition, our understanding of the genetics of these lesions has expanded with the introduction of routine molecular genetic analyses. In this review, we provide an update into the most common intraductal neoplasms, namely intraductal papillary mucinous neoplasm and intraductal tubulopapillary neoplasm...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272683/inflammatory-myofibroblastic-tumor-of-the-stomach-presenting-as-an-exophytic-mass-a-diagnostic-dilemma
#19
Meena Jadhav, Rekha Harvi, Rashmi Patil, Shreekant Kittur
Inflammatory myofibroblastic tumor is an uncommon soft tissue neoplasm of uncertain biologic behavior, and rarely reported in the stomach. An eighteen-year-old male presented with a mass in the epigastrium of three-month duration. Clinical and radiological examination suggested a gastrointestinal stromal tumor or a leiomyoma in the lesser curvature of the stomach. On the basis of histomorphological features and immunohistochemical analysis the diagnosis of inflammatory myofibroblastic tumor in the lesser curvature of the stomach was made...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272682/xanthogranulomatous-pancreatitis-a-rare-case-defying-clinical-radiological-and-tumor-marker-diagnostics-with-a-review-of-literature
#20
Kavita Gaur, Shramana Mandal, Nidhi Mahajan, Sandeep Saluja, Satyajit Godhi
Xanthogranulomatous inflammation of the pancreas is an extremely rare entity mimicking pancreatic neoplasia. Elevation of tumor markers has seldom been reported in xanthogranulomatous inflammation of the pancreas, rendering the diagnosis difficult and highlighting the importance of a meticulous histopathological examination. A 58-year-old male presented with severe abdominal pain and anorexia for six months. A heterogeneously enhancing solid cystic mass was detected in the pancreatic head on contrast enhanced computed tomography...
February 4, 2017: Türk Patoloji Dergisi
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