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Türk Patoloji Dergisi

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https://www.readbyqxmd.com/read/28044310/the-diagnostic-and-prognostic-utility-of-dog1-expression-on-gastrointestinal-stromal-tumors
#1
Sevinç Şahin, Özgür Ekinci, Selda Seçkin, Ayşe Dursun
OBJECTIVE: We aimed to review our archives in order to evaluate both the diagnostic and prognostic significance of DOG1 on gastrointestinal stromal tumors (GISTs), and add further insight about those issues to the current literature including some conflicting results. MATERIAL AND METHOD: DOG1 was evaluated in 100 cases of GISTs, immunohistochemically. Immunostaining index was counted for each antibody by using both the intensity and extent of staining. The association between immunostaining index of DOG1 and CD117, CD34, SMA desmin, S-100, and Ki-67 index and clinicopathological features were analyzed...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044309/improving-histopathology-laboratory-productivity-process-consultancy-and-a3-problem-solving
#2
Kutsal Yörükoğlu, Erdener Özer, Birsen Alptekin, Cem Öcal
OBJECTIVE: The ISO 17020 quality program has been run in our pathology laboratory for four years to establish an action plan for correction and prevention of identified errors. In this study, we aimed to evaluate the errors that we could not identify through ISO 17020 and/or solve by means of process consulting. Process consulting is carefully intervening in a group or team to help it to accomplish its goals. MATERIAL AND METHOD: The A3 problem solving process was run under the leadership of a 'workflow, IT and consultancy manager'...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044308/expression-of-monomeric-c-reactive-protein-in-infarcted-brain-tissue-from-patients-with-alzheimer-s-disease
#3
Mark Slevin, Donghui Liu, Glenn Ferris, Malik Al-Hsinawi, Raid Al-Baradie, Jerzy Krupinski
OBJECTIVE: We have previously shown that monomeric-C-reactive protein is deposited in significant quantities within the brain parenchyma after stroke. Since we have recently identified a possible role of this protein in supporting neurodegeneration and aberrant vascular development we identified a small group of post-mortem brain samples from individuals who had Alzheimer's disease and evidence of tissue infarction/ micro-infarction on histological examination. MATERIAL AND METHOD: We used immunohistochemistry staining to identify the monomeric-C-reactive protein expressed in the infarcted brain tissues...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044307/expression-of-p63-p53-and-ki-67-in-patients-with-cervical-intraepithelial-neoplasia
#4
Androniks Mitildzans, Anastasija Arechvo, Dace Rezeberga, Sergejs Isajevs
OBJECTIVE: Cervical intraepithelial neoplasia (CIN) is a dysplastic process in cervical squamous epithelium and carries a risk of progression to cervical cancer. The aim of this study was to compare expression of three biomarkers named p53, p63 and Ki-67 in patients with various grades of cervical intraepithelial neoplasia and in a control group. MATERIAL AND METHOD: 58 patients were enrolled in the study. Each patient underwent a colposcopy-guided biopsy of the cervix...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044306/a-comparative-study-of-activity-based-costing-vs-current-pricing-system-for-pathology-examinations-at-okmeydani-training-and-research-hospital-turkey
#5
Enver Yarikkaya, Selver Özekinci, Aytül Sargan, Şenay Erdoğan Durmuş, Fetin Rüştü Yildiz
OBJECTIVE: To provide real cost data for pathology examinations by using activity-based costing method, in order to provide means to departments, health administrators and the social security institution to achieve improvements in financial planning, quality and cost control. MATERIAL AND METHOD: The cost of the histopathological examinations, which were accepted by the Department of Pathology at Okmeydanı Training and Research Hospital during August 2014, was calculated using the activity-based costing method...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044305/clinicopathological-analysis-of-mediastinal-masses-a-mixed-bag-of-non-neoplastic-and-neoplastic-etiologies
#6
Preeti Sharma, Vidya Jha, Naveen Kumar, Rohit Kumar, Ashish Mandal
OBJECTIVE: The mediastinum is the central portion of the thoracic cavity, housing numerous organs and harbouring a mixed bag of non-neoplastic and neoplastic lesions. Accurate diagnosis is essential owing to the widely variable therapeutic and prognostic implications. MATERIAL AND METHOD: Cases of mediastinal masses were retrospectively reviewed from January 2011 till January 2016. Clinico-radiological records of these cases were retrieved. Fine needle aspiration cytology (FNAC) was performed wherever feasible...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044304/review-of-hydatid-cyst-with-focus-on-cases-with-unusual-locations
#7
Sevinç Hallaç Keser, Ayşegül Selek, Dilek Ece, Cem Cahit Barişik, Sibel Şensu, Gonca Gül Geçmen, Selma Şengiz Erhan, Şermin Çoban Kökten, Nagehan Özdemir Barişik, Aylin Ege Gül
OBJECTIVE: This study has been conducted so as to contribute to health statistics of hydatid cyst by the data obtained from our clinic, and to discuss hydatid cysts in unusual locations. MATERIAL AND METHOD: Cases diagnosed as hydatid cyst at Dr. Lutfi Kirdar Kartal Research and Education Hospital Pathology Clinic between 2007 and 2015 have been evaluated based on criteria such as age, sex and location. RESULTS: A total of 364 cases, 209 females and 155 males, have been included in the study...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044303/acinar-adenocarcinoma-of-prostate-with-predominant-ttf-1-positive-intraductal-component
#8
Banu Sarsik, Nisar Karadeniz, Adnan Şimşir, Rahmi Akyol, Kutsal Yörükoğlu, Sait Şen
Intraductal carcinoma of prostate has been previously described in radical prostatectomies. It's rarely encountered in needle biopsies in the absence of infiltrative carcinoma. But, both histogenesis and nomenclature of the lesion is still controversial. Among the pure intraductal carcinoma of prostate cases, a different solid patern was described with smaller nuclei at the center of the ducts. However, there is a lack of information about the association of those cases with acinar prostate adenocarcinoma. Herein, we describe a case of acinar adenocarcinoma with predominant non-neuroendocrine TTF-1 positive small cell intraductal component...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044302/disseminated-cryptococcosis-in-an-immunocompetent-child
#9
Bhawna Bhutoria Jain, Debdas Bose, Rajat Mondal, Sarbani Chattopadhyay
A case of disseminated cryptococcus infection in an immunocompetent host is described. The present case attests to the importance of using a cautious approach for the diagnosis of granulomatous lymphadenitis. The patient was initially misdiagnosed and treated as disseminated tuberculosis. Later the patient developed visual loss and skin lesions. Periodic Acid Schiff stained sections of lymph node biopsy and cerebrospinal fluid culture established the diagnosis.
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044301/primary-pulmonary-mucinous-colloid-adenocarcinoma-that-arose-in-the-cavernomyoplasty-area-in-a-patient-with-tuberculosis-a-rare-case-report
#10
Neşe A Yener, Nesrin Sariman, Mehmet M Atasoy, Ahmet Midi, Alpay Örki
Primary pulmonary mucinous (colloid) adenocarcinoma is a rare type of lung cancer. Its arising in the cavernomyoplasty area has not been reported before. We here describe a sixty-year-old man with a previous history of multidrug-resistant and surgically-treated tuberculosis who was diagnosed as primary mucinous adenocarcinoma in the cavernomyoplasty site. We discuss the relevant literature on this rare entity.
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044300/a-mimicker-of-gallbladder-carcinoma-cystic-gastric-heterotopia-with-intestinal-metaplasia
#11
Gonca Özgün, Şaduman Balaban Adim, Nesrin Uğraş, Sadık Kiliçturgay
Heterotopic gastric mucosa in the gallbladder is an unusual entity and is usually clinically silent. We report a 75-year-old female patient who presented with intermittent upper abdomial pain radiating to the back. Abdominal imaging studies showed a sessile polypoid lesion and a gallstone in the gallbladder. Gallbladder carcinoma was suspected and cholecystectomy performed. Intraoperative frozen section examination suggested mucinous tumor, suspicious for malignancy. However, the permanent sections revealed aberrant gastric tissue consisted of gastric pyloric and fundic glands of heterotopic gastric mucosa with intestinal metaplasia in the gallbladder...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28044299/mucosal-malignant-melanoma-of-nasal-cavity-recurring-a-year-after-radiotherapy
#12
Cem Çomunoğlu, Gamze Mocan Kuzey, Mete Inançli, Füsun Baba, Hanife Özkayalar
OBJECTIVE: Sinonasal mucosal malignant melanoma is a rare entity. In this report we present a nasal mucosal malignant melanoma case with its histopathological and clinical features. CASE REPORT: An 88-year-old female patient presented with epistaxis a month ago. Examination revealed a polypoid mass lesion of right nasal cavity originating from the middle concha. Her medical history revealed that she had been found to have a mass lesion in the right nasal cavity 15 months ago...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562395/adrenocortical-oncocytic-carcinoma-a-case-report-and-review-of-the-histopathologic-diagnostic-criteria
#13
Deniz Arik, Funda Canaz, Emine Dündar
Oncocytic tumors are rare in the adrenal gland. The histopathological diagnosis of adrenocortical carcinoma is difficult due to the lack of precise diagnostic criteria for malignancy. A 44-year-old man was admitted to our hospital with left flank pain. Radiologically an adrenal mass was detected. After the excision and histopathologic evaluation of the mass, a diagnosis of adrenocortical oncocytic carcinoma was made. At least one of the features of more than 5 mitoses in 50 high power fields, atypical mitotic figures or venous invasion is required for the diagnosis of malignancy in adrenocortical tumors...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562394/nasal-polyp-an-incidental-paraganglioma
#14
Ruchi Srivastava, Neelam Wadhwa, Shikha Gupta, Urvashi Razdan
The nose is an uncommon site for head and neck paraganglioma. The diagnosis is seldom established pre-operatively; its rarity, infrequent functionality and often benign biologic outcome underlie this fact. We present one such case in a 60-year-old man who presented with right nasal obstruction and episodic epistaxis. Rhinoscopy revealed a fleshy polypoid mass arising from the anterior cartilaginous nasal septum. Imaging studies excluded extra-nasal extension. The tumor was highly vascular showing numerous variable sized, mostly thin walled branching blood vessels akin to stag-horn shape simulating a vascular neoplasm...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562393/management-and-outcome-of-uveal-melanoma-in-a-single-tertiary-cancer-center-in-jordan
#15
Ahmed Zewar, Ibrahim Nawaiseh, Imad Jaradat, Jakub Khzouz, Khaleel Alrawashdeh, Ghadeer Abdeen, Mustafa Mehyar, Samer Khurma, Yacoub A Yousef
OBJECTIVE: The aim of this study was evaluate the features and outcome of management of uveal melanoma in King Hussein Cancer Center as an example of a referral tertiary cancer center in the Middle East. MATERIAL AND METHOD: This was aetrospective, observational case series of 46 eyes of 46 patients with uveal melanoma. Data collection required access to medical records, radiology and pathology reports, and laboratory results. The main outcome measures included age at diagnosis, tumor location and dimensions, TNM stage, treatment modality, visual outcome, metastasis, and mortality...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562392/comparison-between-her2-estrogen-receptors-and-progesterone-receptors-in-primary-breast-carcinomas-and-matched-lymph-node-metastases
#16
Mohamed Mokhtar Desouki, Ihab Shafek Atta, Daynna J Wolff, Sally E Self
OBJECTIVE: In the current work, we compared HER2 by fluorescence in situ hybridization and estrogen and progesterone receptors by immunohistochemistry in matched primary breast carcinomas and their lymph node metastases. MATERIAL AND METHOD: Thirty-nine cases of primary and lymph node metastases were assessed for HER2. Primary tumors of the cases selected were known to be HER2 negative. Also, immunohistochemistry for estrogen and progesterone receptors was performed on 36 cases from the same cohort to assess any discrepancy between the primary tumor and the lymph node metastases...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562391/a-six-sigma-trial-for-reduction-of-error-rates-in-pathology-laboratory
#17
Zeynep Tosuner, Zühal Gücin, Tuğçe Kiran, Nur Büyükpinarbaşili, Seval Turna, Olcay Taşkiran, Dilek Sema Arici
OBJECTIVE: A major target of quality assurance is the minimization of error rates in order to enhance patient safety. Six Sigma is a method targeting zero error (3.4 errors per million events) used in industry. The five main principles of Six Sigma are defining, measuring, analysis, improvement and control. Using this methodology, the causes of errors can be examined and process improvement strategies can be identified. The aim of our study was to evaluate the utility of Six Sigma methodology in error reduction in our pathology laboratory...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562390/comparison-of-microvessel-density-with-prognostic-factors-in-invasive-ductal-carcinomas-of-the-breast
#18
Ebru Şener, Sare Şipal, Cemal Gündoğdu
OBJECTIVE: Angiogenesis plays a key role in tumor growth and metastasis. Determination of microvessel density is the most common technique used to evaluate the amount of the intratumoral angiogenesis in breast cancer. We have aimed to investigate the relationship with tumor angiogenesis and prognostic parameters in breast invasive ductal carcinomas. MATERIAL AND METHOD: In this study, a total of 100 invasive ductal carcinoma patients, who were diagnosed at the Department of Pathology, Ataturk University Faculty of Medicine between the years 2003-2008, were re-evaluated...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562389/expression-of-neutrophil-gelatinase-associated-lipocalin-and-kidney-injury-molecule-1-in-wilms-tumor
#19
Senem Ersavaş, Gülden Diniz, Hülya Tosun Yildirim, Yetkin Koca, Dudu Solakoğlu Kahraman, Duygu Ayaz, Bengü Demirağ
OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) and Kidney injury molecule-1 (KIM-1) play important roles in both immunity and cell proliferation. It was reported previously that they are overexpressed in various human cancers. The present study was undertaken to examine the expressions of NGAL and KIM-1 in Wilms Tumors. MATERIAL AND METHOD: Tissue samples of 50 Wilms Tumors were evaluated and underwent immunhistochemical staining for NGAL and KIM-1 protein expressions...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/27562388/circulating-tumor-cells-in-breast-cancer-correlation-with-clinicopathological-parameters-hormone-profile-and-microrna-polymorphisms
#20
Cherry Bansal, Mukta Pujani, Sanjeev Misra, A N Srivastava, U S Singh
OBJECTIVE: Circulating tumor cells are isolated tumor cells in the peripheral blood that serve as important prognostic indicators for many kind of tumors. The study was conducted to know the rate of detection of circulating tumor cells among breast cancer patients in comparison with benign breast diseases and control subjects and to know the association between CTC positivity and various clinicopathological parameters, hormonal profile and microRNA polymorphisms. MATERIAL AND METHOD: In the present case control study, we included 182 healthy controls, 108 cases of benign breast disease and 114 breast carcinoma cases...
2016: Türk Patoloji Dergisi
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