journal
https://read.qxmd.com/read/38454775/immunotherapy-of-human-melanoma-past-present-future
#21
JOURNAL ARTICLE
Keywan Mortezaee, Jamal Majidpoor
Immunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in advanced melanoma. Current progress in the field of melanoma immunotherapy is the focus of this review. Solo nivolumab and combo nivolumab-ipilimumab show higher responses compared to solo ipilimumab or chemotherapy...
March 6, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38445701/unlocking-the-immunomodulatory-potential-of-rosmarinic-acid-isolated-from-punica-granatum-l-using-bioactivity-guided-approach-in-silico-in-vitro-and-in-vivo-approaches
#22
JOURNAL ARTICLE
Rupesh K Gautam, Shailesh Mani Tripathi, Shopnil Akash, Sanjay Sharma, Komal Sharma, Swapnil Goyal, Sahar Behzad, Rohit Gundamaraju, Dinesh Kumar Mishra, Yingbo Zhang, Bairong Shen, Sandeep Sundriyal, Rajeev K Singla
BACKGROUND: Punica granatum L. is well-known for its multifaceted therapeutic potential, including anti-inflammatory and immunomodulatory activities. AIM: This study aimed to characterize an immunomodulatory compound isolated from Punica granatum L. using a bioactivity-guided approach. METHODS: Chromatographic techniques were adopted for isolation and purification of secondary metabolites. In silico, in vitro, and in vivo methods were performed to characterize the therapeutic potential of the isolated compound...
March 5, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38441018/defective-mitophagy-impairs-response-to-inflammatory-activation-of-macrophage-like-cells
#23
JOURNAL ARTICLE
Alexander N Orekhov, Alexander D Zhuravlev, Andrey Y Vinokurov, Nikita G Nikiforov, Andrey V Omelchenko, Vasily N Sukhorukov, Vasily V Sinyov, Igor A Sobenin
BACKGROUND AND AIMS: The role of mitophagy in atherosclerosis has been extensively studied during the last few years. It was shown that mitophagy is involved in the regulation of macrophages, which are important players as immune cells in atherosclerosis development. In this study, we investigated the relationship between mitophagy and response to inflammatory stimulation of macrophage-like cells. Six cybrid cell lines with normal mitophagy, that is, increasing in response to stimulation, and 7 lines with defective mitophagy not responding to stimulation were obtained...
March 1, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38425113/nature-s-elixir-for-cancer-treatment-targeting-tumor-induced-neovascularization
#24
JOURNAL ARTICLE
Rani Kumari, Saima Syeda, Anju Shrivastava
Angiogenesis, a multistep process, involves sprouting of new vessels from the pre-existing vessels in response to a stimulus in its microenvironment. Normally, angiogenesis is important for tissue maintenance and homeostasis, however it is also known to be associated with various pathologies, including cancer. Importantly, neovascularization is very crucial for tumors to grow and metastasize since it allows delivery of oxygen and nutrients as well as promotes tumor cell dissemination to distant sites. Activation of angiogenic switch is a consequence of imbalance in pro- as well as anti-angiogenic factors, that are immensely impacted by reactive oxygen species and epigenetic regulation...
February 29, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38425112/ranunculin-protoanemonin-and-anemonin-pharmacological-and-chemical-perspectives
#25
JOURNAL ARTICLE
Betelhem Sirak, Misgana Aragaw, Solomon Tadesse
Ranunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β-glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for use in biological assays. Conversely, anemonin stands out as the optimal molecule for bioassays and demonstrates diverse biological properties, including anti-inflammatory, anti-infective, and anti-oxidant effects...
February 28, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415455/wscd2-expression-its-relevance-to-tumor-infiltrating-immune-cells-and-glioma-prognosis
#26
JOURNAL ARTICLE
Kaderya Abudusalam, Yan Xu, Pazilat Keyumu, Tong Cheng, Manyu Xu, Bing Lu, Pingping Sun, Kadierjiang Musha, Jianfei Huang
BACKGROUND: Patients with glioma have limited treatment options and experience poor prognoses. Therefore, it is urgently needed to explore new diagnostic and therapeutic targets. OBJECTIVE: This study aimed to investigate the relevance of WSC domain-containing 2 (WSCD2) expression to glioma, clinicopathological characteristics, tumor-infiltrating immune cells (TILs), and patient prognosis. METHODS: We analyzed WSCD2 mRNA expression in glioma tissues and patient survival using the Gene Expression Profiling Interactive Analysis database...
February 26, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415454/analysis-and-validation-of-tyrosine-metabolism-related-prognostic-features-for-liver-hepatocellular-carcinoma-therapy
#27
JOURNAL ARTICLE
Zhongfeng Cui, Chunli Liu, Hongzhi Li, Juan Wang, Guangming Li
AIMS: To explore tyrosine metabolism-related characteristics in liver hepatocellular carcinoma (LIHC) and to establish a risk signature for the prognostic prediction of LIHC. Novel prognostic signatures contribute to the mining of novel biomarkers, which are essential for the construction of a precision medicine system for LIHC and the improvement of survival. BACKGROUND: Tyrosine metabolism plays a critical role in the initiation and development of LIHC. Based on the tyrosine metabolism-related characteristics in LIHC, this study developed a risk signature to improve the prognostic prediction of patients with LIHC...
February 26, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38409701/drug-target-affinity-prediction-by-molecule-secondary-structure-representation-network
#28
JOURNAL ARTICLE
Yuewei Tang, Yunhai Li, Pengpai Li, Zhi-Ping Liu
INTRODUCTION: Identification of drug-target interactions (DTI) is a crucial step in drug development with high specificity and low toxicity. To accelerate the process, computer-aided DTI prediction algorithms have been used to screen compounds or targets rapidly. Furthermore, DTI prediction can be used to identify potential targets for existing drugs, thus uncovering new indications and repositioning them. Therefore, it is of great importance to develop efficient and accurate DTI prediction algorithms...
February 22, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38409700/nad-pathways-in-diabetic-coronary-heart-disease-unveiling-the-key-players
#29
JOURNAL ARTICLE
Yuan Liu, Wenjing Zhan, Lexun Wang, Weixuan Wang
Diabetic coronary heart disease is a global medical problem that poses a serious threat to human health, and its pathogenesis is complex and interconnected. Nicotinamide adenine dinucleotide (NAD) is an important small molecule used in the body that serves as a coenzyme in redox reactions and as a substrate for non-redox processes. NAD levels are highly controlled by various pathways, and increasing evidence has shown that NAD pathways, including NAD precursors and key enzymes involved in NAD synthesis and catabolism, exert both positive and negative effects on the pathogenesis of diabetic coronary heart disease...
February 22, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38409699/metformin-effects-on-ship2-ampks-and-gut-microbiota-recent-updates-on-pharmacology
#30
JOURNAL ARTICLE
Priyanka Shivaprakash, Narasimha M Beeraka, Subba Rao V Madhunapantula, Vladimir N Nikolenko, Kanthesh M Basalingappa
INTRODUCTION: Metformin, a biguanide on the WHO's list of essential medicines has a long history of 50 years or more in treating hyperglycemia, and its therapeutic saga continues beyond diabetes treatment. Glucoregulatory actions are central to the physiological effects of metformin; surprisingly, the precise mechanism with which metformin regulates glucose metabolism is not thoroughly understood yet. METHOD: The main aim of this review is to explore the recent implications of metformin in hepatic gluconeogenesis, AMPKs, and SHIP2 and subsequently to elucidate the metformin action across intestine and gut microbiota...
February 21, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38409698/hub-genes-involved-in-the-progression-of-nonalcoholic-fatty-liver-disease-to-hepatocellular-carcinoma
#31
JOURNAL ARTICLE
Baiyi Liu, Xiaoxiao Wang, Nan Wu, Feng Liu, Huiying Rao
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. With an increasing number of patients, NAFLD has been identified as a risk factor for Hepatocellular Carcinoma (HCC). The precise pathophysiology of NAFLD-related HCC has not been completely understood recently. OBJECTIVE: We analyzed the hub genes related to NAFLD and HCC to predict the risk of NAFLD progressing to HCC. METHODS: Two datasets of NAFLD were used to identify differentially expressed genes...
February 21, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415439/rituximab-combined-with-steroid-and-tacrolimus-treats-proliferative-glomerulonephritis-with-monoclonal-igg-deposits-a-case-report-and-review-of-the-literature
#32
Di Liu, Ming Xia, Chang Wang, Xuejing Zhu, Guochun Chen, Hong Liu
INTRODUCTION: Due to the confounding heterogeneity, the therapeutic strategy for proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) remains to be defined. CASE REPRESENTATION: We report a 38-year-old man with recurrent swelling of the eyelids and lower limbs, undergoing rituximab combined with steroid and tacrolimus treatment, who achieved an improved renal outcome. Underlying solid malignant tumours were excluded from the diagnosis. DISCUSSION: We treated patients with rituximab along with steroids and tacrolimus...
February 20, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415438/discussion-on-the-influence-of-gpx-4-target-in-the-field-of-cancer
#33
JOURNAL ARTICLE
Ya-Lan Wang, Hong-Yan Guo, Tong Zhou, Ke Sun, Qing-Kun Shen, Xiao-Ting Li
The current review was undertaken to collate data on Gpx4 inhibitors and the regulatory proteins related to Gpx4. Gpx4 plays an essential role in ferroptosis; it can be used to determine the Gpx4 as an indicator for determining tumor occurrence and as a means of treating cancer. Although there is no market for Gpx4 inhibitors, many researchers have conducted extensive research, and some compounds have entered clinical research. This article summarizes all papers related to Gpx4; hope this review can provide some new insights and ideas for researchers aiming to develop efficient and low-- toxicity Gpx4 inhibitors and provide some new ideas for cancer treatment...
February 20, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415437/clinical-outcomes-and-effectiveness-of-crlx101-for-solid-tumors-a-systematic-review-and-meta-analysis
#34
Nahal Shamaeizadeh, Erfan Sadeghi, Jaleh Varshosaz
BACKGROUND: While it has been demonstrated that delivery of cytotoxic chemotherapy using nanoparticles greatly improves patient drug tolerance and reduces toxicity when compared to the standard formulation, the crucial question of whether they also increase anticancer efficacy remains. The CRLX101 is a nanoparticle composed of cyclodextrin and 20(S)-camptothecin cytotoxic chemotherapy. OBJECTIVE: In order to compare the efficacy of the CRLX101 to its corresponding traditional formulation, we carried out this systematic literature search for randomized clinical and non-randomized trials...
February 20, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415442/evidence-for-the-involvement-of-gene-regulation-of-inflammatory-molecules-in-the-accumulation-of-intracellular-cholesterol-the-mechanism-of-foam-cell-formation-in-atherosclerosis
#35
JOURNAL ARTICLE
Vasily N Sukhorukov, Victoria A Khotina, Daria D Borodko, Mariam Bagheri Ekta, Yumiko Oishi, Andrey V Omelchenko, Kira I Kolmychkova, Nikita G Nikiforov, Igor A Sobenin, Alexander N Orekhov
BACKGROUND: The relationship between the cellular pro-inflammatory response and intracellular lipid accumulation in atherosclerosis is not sufficiently studied. Transcriptomic analysis is one way to establish such a relationship. Previously, we identified 10 potential key genes (IL-15, CXCL8, PERK, IL-7, IL-7R, DUSP1, TIGIT, F2RL1, TSPYL2, and ANXA1) involved in cholesterol accumulation in macrophages. It should be noted that all these genes do not directly participate in cholesterol metabolism, but encode molecules related to inflammation...
February 19, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415441/advanced-targeted-drug-delivery-of-bioactive-agents-fortified-with-graft-chitosan-in-management-of-cancer-a-review
#36
JOURNAL ARTICLE
Rukaiah Begum, Sudarshan Singh, Bhupendra Prajapati, M Sumithra, Ravish J Patel
Cancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation or specific chemicals, and a family history of the disease. Common treatment methods for cancer encompass surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy...
February 19, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38415440/iron-related-biomarkers-in-the-diagnosis-and-management-of-iron-disorders
#37
JOURNAL ARTICLE
Yuliya Semenova, Geir Bjørklund, Monica Butnariu, Massimiliano Peana
BACKGROUND: Iron deficiency and iron-related disorders are common health issues worldwide, affecting a significant proportion of the population. Diagnosis and management of these disorders rely heavily on using various iron-related biomarkers that can provide valuable clinical information. OBJECTIVE: This review article provides an overview of the most commonly used iron-related biomarkers, including serum ferritin, transferrin saturation, soluble transferrin receptor, zinc protoporphyrin, and free erythrocyte protoporphyrin...
February 19, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38375850/natural-phenolic-compounds-with-antithrombotic-and-antiplatelet-effects-a-drug-likeness-approach
#38
JOURNAL ARTICLE
Diégina Araújo Fernandes, Ayala Nara Pereira Gomes, Camila Macaubas da Silva, Isabelly Soares de Medeiros Henriques, Renata Priscila Barros de Menezes, Marcus Tullius Scotti, Yanna Carolina Ferreira Teles, RuAngelie Edrada-Ebel, Maria de Fatima Vanderlei de Souza
BACKGROUND: Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessel diseases. Several studies have been conducted to identify antithrombotic agents from medicinal plants, and phenolic compounds (PCs) have been shown to effectively inhibit plasma coagulation and platelet aggregation. OBJECTIVES: This study aimed to conduct a survey of the natural PCs with proven antithrombotic and antiplatelet activities, as well as to evaluate by computational modeling the physicochemical and toxicological properties of these compounds using drug-likeness approaches...
February 19, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38375849/advanced-targeted-drug-delivery-of-bioactive-nanomaterials-in-the-management-of-cancer
#39
JOURNAL ARTICLE
Biswajit Basu, Kevin Kumar Garala, Rajeshri Patel, Ayon Dutta, Dipanjana Ash, Bhupendra Prajapati, Sudarshan Singh, Sajal Kumar Jha
Cancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do not infiltrate right away, this is particularly true when treating solid tumors. A targeted drug delivery system (TDDS) is a tool that distributes medication to a selected bioactive location in a controlled manner...
February 16, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38375848/mycobacterial-targets-for-thiourea-derivatives-opportunities-for-virtual-screening-in-tuberculosis-drug-discovery
#40
JOURNAL ARTICLE
Vinicius de Melo Milani, Mariana Luiza Silva, Priscila Goes Camargo, Marcelle de Lima Ferreira Bispo
Tuberculosis (TB) remains a primary global health concern, necessitating the discovery and development of new anti-TB drugs, mainly to combat drug-resistant strains. In this context, thiourea derivatives have emerged as promising candidates in TB drug discovery due to their diverse chemical structures and pharmacological properties. This review aimed to explore this potential, identifying and exploring molecular targets for thiourea derivatives in Mycobacterium tuberculosis (Mtb) and the potential application of virtual screening techniques in drug discovery...
February 16, 2024: Current Medicinal Chemistry
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