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Journal of Computational Neuroscience

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https://www.readbyqxmd.com/read/29946922/a-model-of-motor-and-sensory-axon-activation-in-the-median-nerve-using-surface-electrical-stimulation
#1
Jessica L Gaines, Kathleen E Finn, Julia P Slopsema, Lane A Heyboer, Katharine H Polasek
Surface electrical stimulation has the potential to be a powerful and non-invasive treatment for a variety of medical conditions but currently it is difficult to obtain consistent evoked responses. A viable clinical system must be able to adapt to variations in individuals to produce repeatable results. To more fully study the effect of these variations without performing exhaustive testing on human subjects, a system of computer models was created to predict motor and sensory axon activation in the median nerve due to surface electrical stimulation at the elbow...
August 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29923159/dynamics-of-spontaneous-activity-in-random-networks-with-multiple-neuron-subtypes-and-synaptic-noise-spontaneous-activity-in-networks-with-synaptic-noise
#2
Rodrigo F O Pena, Michael A Zaks, Antonio C Roque
Spontaneous cortical population activity exhibits a multitude of oscillatory patterns, which often display synchrony during slow-wave sleep or under certain anesthetics and stay asynchronous during quiet wakefulness. The mechanisms behind these cortical states and transitions among them are not completely understood. Here we study spontaneous population activity patterns in random networks of spiking neurons of mixed types modeled by Izhikevich equations. Neurons are coupled by conductance-based synapses subject to synaptic noise...
June 19, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29882174/numerical-optimization-of-coordinated-reset-stimulation-for-desynchronizing-neuronal-network-dynamics
#3
Shigeru Kubota, Jonathan E Rubin
Excessive synchronization in neural activity is a hallmark of Parkinson's disease (PD). A promising technique for treating PD is coordinated reset (CR) neuromodulation in which a neural population is desynchronized by the delivery of spatially-distributed current stimuli using multiple electrodes. In this study, we perform numerical optimization to find the energy-optimal current waveform for desynchronizing neuronal network with CR stimulation, by proposing and applying a new optimization method based on the direct search algorithm...
June 7, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29869761/convolutional-neural-network-models-of-v1-responses-to-complex-patterns
#4
Yimeng Zhang, Tai Sing Lee, Ming Li, Fang Liu, Shiming Tang
In this study, we evaluated the convolutional neural network (CNN) method for modeling V1 neurons of awake macaque monkeys in response to a large set of complex pattern stimuli. CNN models outperformed all the other baseline models, such as Gabor-based standard models for V1 cells and various variants of generalized linear models. We then systematically dissected different components of the CNN and found two key factors that made CNNs outperform other models: thresholding nonlinearity and convolution. In addition, we fitted our data using a pre-trained deep CNN via transfer learning...
June 5, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29766393/linear-feature-projection-based-real-time-decoding-of-limb-state-from-dorsal-root-ganglion-recordings
#5
Sungmin Han, Jun-Uk Chu, Jong Woong Park, Inchan Youn
Proprioceptive afferent activities recorded by a multichannel microelectrode have been used to decode limb movements to provide sensory feedback signals for closed-loop control in a functional electrical stimulation (FES) system. However, analyzing the high dimensionality of neural activity is one of the major challenges in real-time applications. This paper proposes a linear feature projection method for the real-time decoding of ankle and knee joint angles. Single-unit activity was extracted as a feature vector from proprioceptive afferent signals that were recorded from the L7 dorsal root ganglion during passive movements of ankle and knee joints...
May 15, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29752691/analytical-modelling-of-temperature-effects-on-an-ampa-type-synapse
#6
Dominik S Kufel, Grzegorz M Wojcik
It was previously reported, that temperature may significantly influence neural dynamics on the different levels of brain function. Thus, in computational neuroscience, it would be useful to make models scalable for a wide range of various brain temperatures. However, lack of experimental data and an absence of temperature-dependent analytical models of synaptic conductance does not allow to include temperature effects at the multi-neuron modeling level. In this paper, we propose a first step to deal with this problem: A new analytical model of AMPA-type synaptic conductance, which is able to incorporate temperature effects in low-frequency stimulations...
May 11, 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29797294/the-effect-of-inhibition-on-the-existence-of-traveling-wave-solutions-for-a-neural-field-model-of-human-seizure-termination
#7
L R González-Ramírez, M A Kramer
In this paper we study the influence of inhibition on an activity-based neural field model consisting of an excitatory population with a linear adaptation term that directly regulates the activity of the excitatory population. Such a model has been used to replicate traveling wave data as observed in high density local field potential recordings (González-Ramírez et al. PLoS Computational Biology, 11(2), e1004065, 2015). In this work, we show that by adding an inhibitory population to this model we can still replicate wave properties as observed in human clinical data preceding seizure termination, but the parameter range over which such waves exist becomes more restricted...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29666978/spike-timing-precision-of-neuronal-circuits
#8
Deniz Kilinc, Alper Demir
Spike timing is believed to be a key factor in sensory information encoding and computations performed by the neurons and neuronal circuits. However, the considerable noise and variability, arising from the inherently stochastic mechanisms that exist in the neurons and the synapses, degrade spike timing precision. Computational modeling can help decipher the mechanisms utilized by the neuronal circuits in order to regulate timing precision. In this paper, we utilize semi-analytical techniques, which were adapted from previously developed methods for electronic circuits, for the stochastic characterization of neuronal circuits...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29616382/phase-model-based-neuron-stabilization-into-arbitrary-clusters
#9
Timothy D Matchen, Jeff Moehlis
Deep brain stimulation (DBS) is a common method of combating pathological conditions associated with Parkinson's disease, Tourette syndrome, essential tremor, and other disorders, but whose mechanisms are not fully understood. One hypothesis, supported experimentally, is that some symptoms of these disorders are associated with pathological synchronization of neurons in the basal ganglia and thalamus. For this reason, there has been interest in recent years in finding efficient ways to desynchronize neurons that are both fast-acting and low-power...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29589252/the-role-of-phase-shifts-of-sensory-inputs-in-walking-revealed-by-means-of-phase-reduction
#10
Azamat Yeldesbay, Tibor Tóth, Silvia Daun
Detailed neural network models of animal locomotion are important means to understand the underlying mechanisms that control the coordinated movement of individual limbs. Daun-Gruhn and Tóth, Journal of Computational Neuroscience 31(2), 43-60 (2011) constructed an inter-segmental network model of stick insect locomotion consisting of three interconnected central pattern generators (CPGs) that are associated with the protraction-retraction movements of the front, middle and hind leg. This model could reproduce the basic locomotion coordination patterns, such as tri- and tetrapod, and the transitions between them...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29574632/an-integrate-and-fire-model-to-generate-spike-trains-with-long-range-dependence
#11
Alexandre Richard, Patricio Orio, Etienne Tanré
Long-range dependence (LRD) has been observed in a variety of phenomena in nature, and for several years also in the spiking activity of neurons. Often, this is interpreted as originating from a non-Markovian system. Here we show that a purely Markovian integrate-and-fire (IF) model, with a noisy slow adaptation term, can generate interspike intervals (ISIs) that appear as having LRD. However a proper analysis shows that this is not the case asymptotically. For comparison, we also consider a new model of individual IF neuron with fractional (non-Markovian) noise...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29546529/synaptic-efficacy-shapes-resource-limitations-in-working-memory
#12
Nikhil Krishnan, Daniel B Poll, Zachary P Kilpatrick
Working memory (WM) is limited in its temporal length and capacity. Classic conceptions of WM capacity assume the system possesses a finite number of slots, but recent evidence suggests WM may be a continuous resource. Resource models typically assume there is no hard upper bound on the number of items that can be stored, but WM fidelity decreases with the number of items. We analyze a neural field model of multi-item WM that associates each item with the location of a bump in a finite spatial domain, considering items that span a one-dimensional continuous feature space...
June 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29464489/learning-neural-connectivity-from-firing-activity-efficient-algorithms-with-provable-guarantees-on-topology
#13
Amin Karbasi, Amir Hesam Salavati, Martin Vetterli
The connectivity of a neuronal network has a major effect on its functionality and role. It is generally believed that the complex network structure of the brain provides a physiological basis for information processing. Therefore, identifying the network's topology has received a lot of attentions in neuroscience and has been the center of many research initiatives such as Human Connectome Project. Nevertheless, direct and invasive approaches that slice and observe the neural tissue have proven to be time consuming, complex and costly...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29387993/perceptual-judgments-via-sensory-motor-interaction-assisted-by-cortical-gaba
#14
Osamu Hoshino, Meihong Zheng, Kazuo Watanabe
Recurrent input to sensory cortex, via long-range reciprocal projections between motor and sensory cortices, is essential for accurate perceptual judgments. GABA levels in sensory cortices correlate with perceptual performance. We simulated a neuron-astrocyte network model to investigate how top-down, feedback signaling from a motor network (Nmot) to a sensory network (Nsen) affects perceptual judgments in association with ambient (extracellular) GABA levels. In the Nsen, astrocytic transporters modulated ambient GABA levels around pyramidal cells...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29372434/linearization-of-excitatory-synaptic-integration-at-no-extra-cost
#15
Danielle Morel, Chandan Singh, William B Levy
In many theories of neural computation, linearly summed synaptic activation is a pervasive assumption for the computations performed by individual neurons. Indeed, for certain nominally optimal models, linear summation is required. However, the biophysical mechanisms needed to produce linear summation may add to the energy-cost of neural processing. Thus, the benefits provided by linear summation may be outweighed by the energy-costs. Using voltage-gated conductances in a relatively simple neuron model, this paper quantifies the cost of linearizing dendritically localized synaptic activation...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29327161/effects-of-channel-blocking-on-information-transmission-and-energy-efficiency-in-squid-giant-axons
#16
Yujiang Liu, Yuan Yue, Yuguo Yu, Liwei Liu, Lianchun Yu
Action potentials are the information carriers of neural systems. The generation of action potentials involves the cooperative opening and closing of sodium and potassium channels. This process is metabolically expensive because the ions flowing through open channels need to be restored to maintain concentration gradients of these ions. Toxins like tetraethylammonium can block working ion channels, thus affecting the function and energy cost of neurons. In this paper, by computer simulation of the Hodgkin-Huxley neuron model, we studied the effects of channel blocking with toxins on the information transmission and energy efficiency in squid giant axons...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29222729/coding-of-time-dependent-stimuli-in-homogeneous-and-heterogeneous-neural-populations
#17
Manuel Beiran, Alexandra Kruscha, Jan Benda, Benjamin Lindner
We compare the information transmission of a time-dependent signal by two types of uncoupled neuron populations that differ in their sources of variability: i) a homogeneous population whose units receive independent noise and ii) a deterministic heterogeneous population, where each unit exhibits a different baseline firing rate ('disorder'). Our criterion for making both sources of variability quantitatively comparable is that the interspike-interval distributions are identical for both systems. Numerical simulations using leaky integrate-and-fire neurons unveil that a non-zero amount of both noise or disorder maximizes the encoding efficiency of the homogeneous and heterogeneous system, respectively, as a particular case of suprathreshold stochastic resonance...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29210004/a-mathematical-model-of-recurrent-spreading-depolarizations
#18
Cameron Conte, Ray Lee, Monica Sarkar, David Terman
A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for the initiation and propagation of recurrent cortical spreading depolarizations. The model incorporates biophysical processes not considered in the earlier models. This includes a model for the Na+ -glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29192377/how-does-transient-signaling-input-affect-the-spike-timing-of-postsynaptic-neuron-near-the-threshold-regime-an-analytical-study
#19
Safura Rashid Shomali, Majid Nili Ahmadabadi, Hideaki Shimazaki, Seyyed Nader Rasuli
The noisy threshold regime, where even a small set of presynaptic neurons can significantly affect postsynaptic spike-timing, is suggested as a key requisite for computation in neurons with high variability. It also has been proposed that signals under the noisy conditions are successfully transferred by a few strong synapses and/or by an assembly of nearly synchronous synaptic activities. We analytically investigate the impact of a transient signaling input on a leaky integrate-and-fire postsynaptic neuron that receives background noise near the threshold regime...
April 2018: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29230640/new-class-of-reduced-computationally-efficient-neuronal-models-for-large-scale-simulations-of-brain-dynamics
#20
Maxim Komarov, Giri Krishnan, Sylvain Chauvette, Nikolai Rulkov, Igor Timofeev, Maxim Bazhenov
During slow-wave sleep, brain electrical activity is dominated by the slow (< 1 Hz) electroencephalogram (EEG) oscillations characterized by the periodic transitions between active (or Up) and silent (or Down) states in the membrane voltage of the cortical and thalamic neurons. Sleep slow oscillation is believed to play critical role in consolidation of recent memories. Past computational studies, based on the Hodgkin-Huxley type neuronal models, revealed possible intracellular and network mechanisms of the neuronal activity during sleep, however, they failed to explore the large-scale cortical network dynamics depending on collective behavior in the large populations of neurons...
February 2018: Journal of Computational Neuroscience
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