Si-Min Lu, Bo Yang, Zhang-Bin Tan, Hui-Juan Wang, Jun-di Xie, Meng-Ting Xie, Wei-Hao Jiang, Jin-Zhou Huang, Jun Li, Lei Zhang, Yong-Zhen Tan, Jing-Zhi Zhang, Bin Liu, Wei-Wei Wu, Shuang-Wei Zhang
BACKGROUND: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferroptosis has been reported in the SICD. TaoHe ChengQi decoction (THCQD), a classical traditional Chinese medicinal formula, has multiple beneficial pharmacological effects. The potential effects of THCQD on the SICD remain unknown. PURPOSE: To investigate the effect of THCQD on SICD and explore whether this effect is related to the regulation of myocardial ferroptosis through nuclear factor erythroid 2-related factor 2 (Nrf2) activation...
April 20, 2024: Phytomedicine