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Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

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https://www.readbyqxmd.com/read/30392747/implementation-of-the-nagoya-protocol-in-the-european-union-and-in-germany
#1
Thomas Greiber
BACKGROUND: In 2014 the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization entered into force. The Protocol aims to further concretize and improve the implementation of the access and benefit-sharing (ABS) obligations already foreseen under the Convention on Biological Diversity (CBD) since 1993. The European Union has accepted the challenge to establish the necessary monitoring and compliance measures which are envisaged in the Nagoya Protocol...
October 26, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30343946/corrigendum-to-anti-inflammatory-and-antiviral-activities-of-cynanversicoside-a-and-cynanversicoside-c-isolated-from-cynanchun-paniculatum-in-influenza-a-virus-infected-mice-pulmonary-microvascular-endothelial-cells-phytomedicine-36-2017-18-25
#2
Panying Wei, Tao Zhang, Hong Dong, Qiaohong Chen, Xiang Mu, Ge Hu
No abstract text is available yet for this article.
October 17, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30385134/puerarin-inhibits-hyperglycemia-induced-inter-endothelial-junction-through-suppressing-endothelial-nlrp3-inflammasome-activation-via-ros-dependent-oxidative-pathway
#3
Dawei Lian, Huiqi Yuan, Xiongzhang Yin, Yanjiao Wu, Rongrong He, Yi Huang, Yang Chen
BACKGROUND: Recent studies indicate that vascular complications are closely related to diabetes mellitus; in particular, inflammatory-mediated endothelial dysfunction plays a crucial role in diabetes-induced cardiovascular diseases. Therefore, exploring effective methods to suppress endothelial dysfunction via inhibition of inflammatory responses is imperative. Puerarin (Pu), a flavonoid common in Pueraria, has been widely and successfully used to treat cardiovascular diseases in China for many years...
October 11, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30392748/metabolomics-study-of-the-hepatoprotective-effect-of-phellinus-igniarius-in-chronic-ethanol-induced-liver-injury-mice-using-uplc-q-tof-ms-combined-with-ingenuity-pathway-analysis
#4
REVIEW
Yu Dong, Ping Qiu, Lisha Zhao, Pinghu Zhang, Xiaowen Huang, Changyu Li, Kequn Chai, Dan Shou
BACKGROUND: Phellinus igniarius (L.) Quèl as a potential medicinal mushroom possesses multiple biological activities including hepatoprotection, but the hepatoprotective mechanism is not clear. PURPOSE: To elucidate the hepatoprotective effect and potential target of P. igniarius. METHODS: The male C57BL/6 mice were fed with the Lieber-DeCarli diet containing alcohol or isocaloric maltose dextrin as control diet with or without P. igniarius decoction (PID) in the dosage of 0...
October 2, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30389273/modulation-of-hepatic-lipidome-by-rhodioloside-in-high-fat-diet-fed-apolipoprotein-e-knockout-mice
#5
Shi-Yuan Wen, Yan-Yan Chen, Jia-Xi Lu, Qian-Qian Liang, Hong Shi, Qian Wu, Zhi-Hong Yao, Yan Zhu, Miao-Miao Jiang
BACKGROUND: Rhodioloside is a glucoside of tyrosol isolated from Rhodiola rosea. However, its regulating effect on hepatic dyslipidemia of atherogenic mice has rarely been studied. PURPOSE: The specific aims of current study included to clarify lipidomic perturbation in liver tissues of apolipoprotein E deficient (apoE-/- ) mice fed with high-fat diet, and to examine the effects of rhodioloside against atherosclerosis and dyslipidemia. STUDY DESIGN: The comparisons of hepatic lipidome were executed between wide type (WT) mice fed with normal diet (NDC) and apoE-/- mice fed with high-fat diet (Model), WT mice fed with high-fat diet (HFDC) versus the model mice, as well as the model mice versus rhodioloside-treated atherosclerotic mice...
September 27, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30385133/neuroprotective-effects-of-baicalein-in-animal-models-of-parkinson-s-disease-a-systematic-review-of-experimental-studies
#6
Qi Zhu, Xuxu Zhuang, Jiahong Lu
BACKGROUND: There is an increasing of reports describing the efficacy of neuroprotective small molecule in Parkinson's disease (PD) models. Ideally, the choice of pushing drug candidates to clinical trial should be based on an unbiased assessment of all available data. Systematic review uses a methodical approach to minimize the bias in the selection of studies for inclusion, providing a comprehensive understanding of the drug's effects on multiple animal models with different mechanism...
September 27, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30293859/molecular-mechanism-underlying-orofacial-antinociceptive-activity-of-vanillosmopsis-arborea-baker-asteraceae-essential-oil-complexed-with-%C3%AE-cyclodextrin
#7
Laura Hévila I Leite, Gerlânia O Leite, Bruno Anderson F da Silva, Sacha Aubrey A R Santos, Francisco Ernani A Magalhães, Paula P Menezes, Mairim R Serafini, Claudener S Teixeira, Renan G Brito, Priscila L Santos, José Galberto M da Costa, Adriano A S Araújo, Lucindo J Quintans-Júnior, Irwin R A de Menezes, Henrique Douglas M Coutinho, Adriana Rolim Campos
BACKGROUND: Vanillosmopsis arborea Baker has recognized economic value owing to the high content of (-)-α-bisabolol (BISA) in the essential oil of its stem (EOVA). The antinociceptive effect of EVOA has already been demonstrated, and β-cyclodextrin (βCD) is known to improve the analgesic effect of various substances. PURPOSE: Thus, we aimed to evaluate the orofacial antinociceptive effect of a complex containing EOVA-βCD in rodents. METHODS: EOVA was obtained by simple hydrodistillation, and the essential oil was complexed with βCD...
September 17, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217266/effects-of-marantodes-pumilum-kacip-fatimah-on-vaginal-ph-and-expression-of-vacoular-atpase-and-carbonic-anhydrase-in-the-vagina-of-sex-steroid-deficient-female-rats
#8
Nelli Giribabu, Kamarulzaman Karim, Naguib Salleh
BACKGROUND: In sex-steroid deficiency, increased in the pH of vaginal fluid is due to low estrogen levels. HYPOTHESIS: Consumption of Marantodes pumilum leaves helps to ameliorate increased in vaginal fluid pH in sex-steroid deficient condition. PURPOSE: To investigate changes in vaginal fluid pH and expression of proteins that participate in pH changes i.e vacoular (V)-ATPases and carbonic anhydrases (CA) in the vagina following M. pumilum leaves consumption...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217265/metabolic-profiling-of-hypoxia-reoxygenation-injury-in-h9c2-cells-reveals-the-accumulation-of-phytosphingosine-and-the-vital-role-of-dan-shen-in-xin-ke-shu
#9
Lili Sun, Hongmei Jia, Liyan Ma, Meng Yu, Yong Yang, Yang Liu, Hongwu Zhang, Zhongmei Zou
BACKGROUND: Xin-Ke-Shu (XKS), a patent medicine consisting of five commonly used traditional Chinese herbs, is used for the treatment of coronary heart diseases. A previous study showed that XKS has protective effects for ameliorating myocardial ischemia/reperfusion (I/R) injury. PURPOSE: This study was aimed to deeply understand the mechanisms and compatible principle of XKS against hypoxia/reoxygenation (H/R) injury and the contribution of each single herb to the efficacy of XKS...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217264/inhibitory-effect-of-ligustrum-vulgare-leaf-extract-on-the-development-of-neuropathic-pain-in-a-streptozotocin-induced-rat-model-of-diabetes
#10
Monika E Czerwińska, Emilia Gąsińska, Anna Leśniak, Paulina Krawczyk, Anna K Kiss, Marek Naruszewicz, Magdalena Bujalska-Zadrożny
BACKGROUND: Chronic hyperalgesia and allodynia associated with progressive damage of peripheral neurons are the most prevalent complications of diabetes mellitus. Plants belonging to the family of Oleaceae were traditionally used in folk medicine for the management of diabetes. HYPOTHESIS/PURPOSE: The aim of this study was to investigate whether an aqueous extract from the leaves of Ligustrum vulgare (common privet) could be useful to target neuropathic pain in a rat streptozotocin (STZ) model of diabetes...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217263/rhein-augments-atra-induced-differentiation-of-acute-promyelocytic-leukemia-cells
#11
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, SungHoo Jegal, Yookyung Jeong, Jaekyung Cheon, SuJin Koh, Jin Ho Baek, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
BACKGROUND: Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid), a natural anthraquinone derivative, is a traditional Chinese herb that has been used as a medication in many Asian countries. It has been used as a laxative and stomach drug for a long time in both China and Korea. It is well-known to have many pharmacological activities, such as anti-cancer, anti-bacterial, anti-fungal, anti-oxidant, anti-atherogenic, anti-angiogenic, anti-fibrosis, anti-inflammatory, hepatoprotective, and nephroprotective properties...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217262/coptidis-rhizoma-inhibits-nlrp3-inflammasome-activation-and-alleviates-renal-damage-in-early-obesity-related-glomerulopathy
#12
Yanlin Ren, Dingkun Wang, Fuer Lu, Xin Zou, Lijun Xu, Kaifu Wang, Wenya Huang, Hao Su, Chu Zhang, Yang Gao, Hui Dong
BACKGROUND: Obese subjects have been considered to be in a state of chronic, low-grade systemic inflammation. Excess fat accumulation and persistent inflammation may promote renal dysfunction, to cause chronic kidney disease (CKD) and even end-stage kidney failure. Coptidis Rhizoma is a classical traditional Chinese herb well known for its hypoglycemic and hypolipidemic properties. The mechanism is partially associated with its anti-inflammatory effect. However, this effect is rarely investigated in obesity and obesity-related glomerulopathy (ORG)...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217261/honokiol-enhances-temozolomide-induced-apoptotic-insults-to-malignant-glioma-cells-via-an-intrinsic-mitochondrion-dependent-pathway
#13
Chung-Ching Chio, Yu-Ting Tai, Mahendravarman Mohanraj, Shing-Hwa Liu, Shun-Tai Yang, Ruei-Ming Chen
BACKGROUND: Temozolomide (TMZ) is a first-line chemotherapeutic drug for malignant gliomas. Nonetheless, TMZ-induced side effects and drug resistance remain challenges. Our previous study showed the suppressive effects of honokiol on growth of gliomas. PURPOSE: This study was further aimed to evaluate if honokiol could enhance TMZ-induced insults toward malignant glioma cells and its possible mechanisms. METHODS: Human U87 MG glioma cells were exposed to TMZ, honokiol, and a combination of TMZ and honokiol...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217260/influence-of-silibinin-and-%C3%AE-%C3%AE-dimethylacrylshikonin-on-chordoma-cells
#14
Jahanafrooz Zohreh, Stallinger Alexander, Anders Ines, Kleinegger Florian, Lohberger Birgit, Durchschein Christin, Bauer Rudolf, Deutsch Alexander, Rinner Beate, Kretschmer Nadine
BACKGROUND: Chordoma, slow growing bone tumours originating from remnants of the notochord, leave affected patients with a median survival of six years. The high recurrence rate of chordoma, together with limited treatment options and bad overall prognosis, make the development of new treatment options urgently necessary. PURPOSE: In this study, the potential of two natural products, silibinin and β-β-dimethylacrylshikonin (DMAS), was tested on clival (MUG-CC1 and UM-Chor1) as well as sacral (MUG-Chor1 and U-CH2) chordoma cell lines...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217259/in-vitro-inhibitory-properties-of-sesquiterpenes-from-chloranthus-serratus-on-cell-motility-via-down-regulation-of-limk1-activation-in-human-breast-cancer
#15
Jianjiang Fu, Juanjuan Yu, Jie Chen, Huanjun Xu, Yongming Luo, Hong Lu
BACKGROUND: LIM kinase 1 plays an important role in tumor cell invasion and metastasis by regulating architecture of actin cytoskeleton, and inhibiting activity of this kinase may be a promising strategy to prevent cancer cells from distant spread. In our previous studies, we found several extracts from the medical herbs in genus Chloranthus to exhibit anti-metastatic effects. PURPOSE: The aim of this study is to find LIMK1 inhibitors from Chloranthus serratus, a medical herb from genus Chloranthus and to evaluate their effects on cell motility...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217258/vitis-amurensis-rupr-a-review-of-chemistry-and-pharmacology
#16
REVIEW
Qing Chen, Lichao Diao, Hua Song, Xuan Zhu
PURPOSE: Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for several hundred years as a traditional Chinese herb. The review focuses on the botanical description, traditional uses, phytochemistry, and the biological activities of Vitis amurensis Rupr. to evaluate its therapeutic potential uses. METHODS: This review summarizes the published data concerning the botanical aspects, traditional usage, phytochemistry, and pharmacology of Vitis amurensis Rupr...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217257/potent-anti-inflammatory-effects-of-honokiol-in-human-fetal-membranes-and-myometrium
#17
Yasaswi Kaumadha Wijesuriya, Martha Lappas
BACKGROUND: Preterm birth is the most prominent complication attributing to poor pregnancy and neonatal outcome. Infection is most commonly implicated in preterm birth; it initiates a cascade of inflammatory events that leads to the rupture of fetal membranes and spontaneous uterine contractions. Anti-inflammatory agents may thus be a therapeutic approach to prevent the premature rupture of fetal membranes and block contractions. In non-gestational tissues, the polyphenol honokiol has been shown to possess potent anti-inflammatory properties...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217256/renoprotective-effect-of-spirulina-platensis-extract-against-nicotine-induced-oxidative-stress-mediated-inflammation-in-rats
#18
Walid E Zahran, Manal A Emam
BACKGROUND: Nicotine is an important factor in the pathogenesis of renal injury in smokers. PURPOSE: The purpose of the present study was to investigate the renoprotective effect of Spirulina platensis extract (SP) against chronic nicotine administration in rats. METHODS: Nicotine intoxication was induced with 0.5 mg/kg BW. Rats received 500 mg SP/kg BW by gastric gavage over 4 weeks. RESULTS: Our data revealed that nicotine induced renal dysfunction manifested by significant abnormal levels of kidney function markers (creatinine and urea) accompanied by increased levels of oxidative stress biomarker (malondialdehyde) and inflammatory markers (nitric oxide, Interleukin-6 and tumor necrosis factor-α) while antioxidant status as glutathione level and glutathione S-transferase activity were found to be decreased significantly as compared with controls...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217255/antioxidant-property-of-taraxacum-formosanum-kitam-and-its-antitumor-activity-in-non-small-cell-lung-cancer-cells
#19
John Tung Chien, Ru-Hui Chang, Chia-Hung Hsieh, Chih-Yu Hsu, Chi-Chung Wang
BACKGROUND: Non-small-cell lung cancer (NSCLC) is known to exhibit resistance to various therapeutic agents and become progressively incurable. Taraxacum formosanum is a medicinal Chinese herb that has been clinically used in Taiwan. However, the investigations of the effects of whole plant on lung cancer are limited. PURPOSE: This study evaluated the in vitro antioxidant, antiproliferative, and antimigration effects of the ethanol extract of T. formosanum (ETF)...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195885/effect-of-ginkgo-biloba-extract-761-on-motor-functions-in-permanent-middle-cerebral-artery-occlusion-rats
#20
Gui-Rong Zeng, Shi-da Zhou, Ya-Jie Shao, Miao-Hong Zhang, Li-Ming Dong, Jing-Wei Lv, Hong-Xia Zhang, Ya-Hui Tang, De-Jian Jiang, Xin-Min Liu
BACKGROUND: Ginkgo biloba extract (EGb-761) has been in use to treat variety of ailments including memory loss and emotional disorders usually experienced after ischemic stroke. However, data regarding its protective role in stroke associated motor dysfunction is scarce. PURPOSE: The present work was designed to investigate the long-term effects of EGb-761 on the motor dysfunctions associated with permanent middle cerebral artery occlusion (pMCAO) in rats. STUDY DESIGN/METHODS: Focal ischemic stroke was induced in male Sprague-Dawley rats by pMCAO...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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