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Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

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https://www.readbyqxmd.com/read/29778318/quality-specifications-for-articles-of-botanical-origin-from-the-united-states-pharmacopeia
#1
Cuiying Ma, Hellen Oketch-Rabah, Nam-Cheol Kim, Maria Monagas, Anton Bzhelyansky, Nandakumara Sarma, Gabriel Giancaspro
BACKGROUND: In order to define appropriate quality of botanical dietary supplements, botanical drugs, and herbal medicines, the United States Pharmacopeia (USP) and the Herbal Medicines Compendium (HMC) contain science-based quality standards that include multiple interrelated tests to provide a full quality characterization for each article in terms of its identity, purity, and content. PURPOSE: To provide a comprehensive description of the pharmacopeial tests and requirements for articles of botanical origin in the aforementioned compendia...
April 10, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29699843/novel-mathematic-models-for-quantitative-transitivity-of-quality-markers-in-extraction-process-of-the-buyanghuanwu-decoction
#2
Yu-Tian Zhang, Mei-Feng Xiao, Kai-Wen Deng, Yan-Tao Yang, Yi-Qun Zhou, Jin Zhou, Fu-Yuan He, Wen-Long Liu
BACKGROUND: Nowadays, to research and formulate an efficiency extraction system for Chinese herbal medicine, scientists have always been facing a great challenge for quality management, so that the transitivity of Q-markers in quantitative analysis of TCM was proposed by Prof. Liu recently. In order to improve the quality of extraction from raw medicinal materials for clinical preparations, a series of integrated mathematic models for transitivity of Q-markers in quantitative analysis of TCM were established...
April 6, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685365/identify-super-quality-markers-from-prototype-based-pharmacokinetic-markers-of-tangzhiqing-tablet-tzq-based-on-in-vitro-dissolution-permeation-and-in-vivo-absorption-correlations
#3
Ziqiang Li, Jia Liu, Yazhuo Li, Xi Du, Yanfen Li, Ruihua Wang, Chunxiao Lv, Xin He, Baohe Wang, Yuhong Huang, Deqin Zhang
BACKGROUND: A quality marker (Q-marker) is defined as an inherent chemical compound that is used for the quality control of a drug. Its biological activities are closely related to safety and therapeutic effects. Generally, a multiple-component herbal medicine may have many Q-markers. We therefore proposed a concept of "super Q-marker" satisfying both the criterion of Q-markers and PK-markers to be used in more effective quality control of herbal medicine. PURPOSE: The first aim was to find suitable prototype-based PK-markers from Tangzhiqing tablets (TZQ), a Chinese patent medicine...
April 4, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29705003/an-integrated-approach-to-uncover-quality-marker-underlying-the-effects-of-alisma-orientale-on-lipid-metabolism-using-chemical-analysis-and-network-pharmacology
#4
Maoliang Liao, Haihua Shang, Yazhuo Li, Tian Li, Miao Wang, Yanan Zheng, Wenbin Hou, Changxiao Liu
BACKGROUND: Quality control of traditional Chinese medicines is currently a great concern, due to the correlation between the quality control indicators and clinic effect is often questionable. According to the "multi-components and multi-targets" property of TCMs, a new special quality and bioactivity evaluation system is urgently needed. PURPOSE: Present study adopted an integrated approach to provide new insights relating to uncover quality marker underlying the effects of Alisma orientale (AO) on lipid metabolism...
April 3, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685367/rapid-characterization-of-chemical-markers-for-discrimination-of-moutan-cortex-and-its-processed-products-by-direct-injection-based-mass-spectrometry-profiling-and-metabolomic-method
#5
Chao-Ran Li, Meng-Ning Li, Hua Yang, Ping Li, Wen Gao
BACKGROUND: Processing of herbal medicines is a characteristic pharmaceutical technique in Traditional Chinese Medicine, which can reduce toxicity and side effect, improve the flavor and efficacy, and even change the pharmacological action entirely. It is significant and crucial to perform a method to find chemical markers for differentiating herbal medicines in different processed degrees. PURPOSE: The aim of this study was to perform a rapid and reasonable method to discriminate Moutan Cortex and its processed products, and to reveal the characteristics of chemical components depend on chemical markers...
April 3, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685366/identifying-quality-markers-from-shengmai-san-protects-against-transgenic-mouse-model-of-alzheimer-s-disease-using-chinmedomics-approach
#6
Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Qing-Yu Zhang, Xi-Jun Wang
BACKGROUND: Shengmai San (SMS), a Chinese classic herbal formula, has been widely used for the treatment of Qi-Yin deficiency syndrome in Asia. Modern pharmacological studies have shown that SMS improves the cognitive function. However, the quality markers (Q-markers) for SMS still need further research. PURPOSE: Using chinmedocmics strategy to systematically evaluate the efficacy of SMS in the treatment of APPswe/PS1dE9 (APP/PS1) transgenic model of Alzheimer's disease (AD) and to discover the efficacy-related Q-markers...
April 3, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29691116/exploring-the-q-marker-of-sweat-soaking-method-processed-radix-wikstroemia-indica-based-on-the-effect-toxicity-chemicals-study
#7
Guo Feng, Yun-Long Chen, Wei Li, Lai-Lai Li, Zeng-Guang Wu, Zi-Jun Wu, Yue Hai, Si-Chao Zhang, Chuan-Qi Zheng, Chang-Xiao Liu, Xin He
BACKGROUND: Radix Wikstroemia indica (RWI), named "Liao Ge Wang" in Chinese, is a kind of toxic Chinese herbal medicine (CHM) commonly used in Miao nationality of South China. "Sweat soaking method" processed RWI could effectively decrease its toxicity and preserve therapeutic effect. However, the underlying mechanism of processing is still not clear, and the Q-markers database for processed RWI has not been established. PURPOSE: Our study is to investigate and establish the quality evaluation system and potential Q-markers based on "effect-toxicity-chemicals" relationship of RWI for quality/safety assessment of "sweat soaking method" processing...
March 28, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29699844/research-on-q-markers-of-qiliqiangxin-capsule-for-chronic-heart-failure-treatment-based-on-pharmacokinetics-and-pharmacodynamics-association
#8
Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao
BACKGROUND: Qiliqiangxin capsule (QLQX), composed of 11 herbs, is an effective traditional Chinese medicine (TCM) that has been widely used for treatment of chronic heart failure (CHF) in China. In the Chinese pharmacopoeia (Ch.P.) only astragaloside was described as the marker component to control the quality of QLQX, which could not reflect the overall effectiveness. PURPOSE: The aim of this work was to investigate the quality markers (Q-markers) of QLQX based on the association of the pharmacodynamics (PD) of inhibitory effect on activated renin-angiotensin-aldosterone system (RAAS) and the pharmacokinetics (PK) of bioactive compounds according to the Q-marker theory...
March 21, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29631806/determination-of-quality-markers-of-xuezhiling-tablet-for-hyperlipidemia-treatment
#9
Chaohong Nie, Fugeng Zhang, Xiaowei Ma, Rui Guo, Shuiping Zhou, Libin Zhao, Haiyu Xu, Xuefeng Xiao, Zhuju Wang
BACKGROUND: The massive number of ingredients in traditional Chinese medicines (TCMs) makes quality control very difficult. The concept of quality markers (Q-marker) was recently proposed to evaluate the quality of TCMs. Xuezhiling tablets (XZL) are widely used for the treatment of hyperlipidemia in China owing to its noticeable effectiveness and mild adverse effects, but there are no proper Q-markers for this Chinese patent medicine. PURPOSE: The aim of the present study was to determine the Q-markers of XZL against hyperlipidemia through an integration of investigations on its lipid-lowering effect, metabolomics, content determination and pharmacokinetics...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29573911/limonene-promotes-osteoblast-differentiation-and-2-deoxy-d-glucose-uptake-through-p38mapk-and-akt-signaling-pathways-in-c2c12-skeletal-muscle-cells
#10
Ilavenil Soundharrajan, Da Hye Kim, Srigopalram Srisesharam, Palaniselvam Kuppusamy, Ravikumar Sivanesan, Ki Choon Choi
BACKGROUND: Limonene is a cyclic monoterpene (CTL) found in citrus fruits and many plant kingdoms. It has attracted attention as potential molecule due to its diverse biological activities. However, molecular mechanism involved in the osteogenic induction of CTL in C2C12 skeletal muscle cells remain unclear. PURPOSE: Skeletal development maintains the bone homeostasis through bone remodeling process. It coordinated between the osteoblast and osteoblast process. Osteoporosis is one of the most common bone diseases caused by a systemic reduction in bone mass...
March 12, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29550178/a-novel-concept-of-q-markers-molecular-connectivity-index
#11
Wen-Long Liu, Xi-Li Zhang, Shi-Qi Fan, Jun-Ping Zhu, Hui-Hui Liang, Yu-Tian Zhang, Mei-Feng Xiao, Yan Zeng, Hong He, Fu-Yuan He, Xiao-Qin Xiao
BACKGROUND: Drugs derived from botany have been playing essential role in both clinical treatment and pharmaceutical industry, unfortunately our worry is still that its quality and therapeutic efficacy are inconsistent. Recently many scientists launched a new project on quality (Q)-marker of medicinal herbs, this study was thus designed to generate a novel concept of quality (Q)-markers: molecular connectivity index (MCI), and to test and verify the new concept of molecular connectivity index (MCI)...
March 8, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29576266/exploring-lipid-markers-of-the-quality-of-coix-seeds-with-different-geographical-origins-using-supercritical-fluid-chromatography-mass-spectrometry-and-chemometrics
#12
Jin-Jun Hou, Chun-Mei Cao, Yong-Wei Xu, Shuai Yao, Lu-Ying Cai, Hua-Li Long, Qi-Rui Bi, Yuan-Yuan Zhen, Wan-Ying Wu, De-An Guo
BACKGROUND: Lipids, a group of primary metabolites, could be used as quality markers of Traditional Chinese medicine. PURPOSE: The present study was designed to develop a research method to explore lipid markers of the quality of coix seeds with different geographical origins. STUDY DESIGN: The geographical origins of coix seeds were divided into three regions based on the latitude. A central composite design (CCD test) was used to optimize the chromatographic parameters of supercritical fluid chromatography to obtain optimal lipid profile of coix seed...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29555366/application-of-tqsm-polypharmacokinetics-and-its-similarity-approach-to-ascertain-q-marker-by-analyses-of-transitivity-in-vivo-of-five-candidates-in-buyanghuanwu-injection
#13
Yu-Tian Zhang, Mei-Feng Xiao, Qiong Liao, Wen-Long Liu, Kai-Wen Deng, Yi-Qun Zhou, Yu Tang, Fu-Yuan He, Yan-Tao Yang
BACKGROUND: It is well-known that the public still have been facing on a severe issue about the inconsistency of quality and therapeutic efficacy of traditional medicines. Recently, Professor Chang-Xiao Liu has created a new promising concept for identifying relevant quality-markers (Q-marker) from herbs, their formulas and manufacturing products. Therefore, building up a new approach is necessary for us to bridge over quality to efficacy of pharmaceutical products. STUDY DESIGN: In this paper, five candidate Q-markers, astragaloside IV, paeonflorin, amygdalin, tetramethylpyrazine, ferulic acid in Buyanghuanwu injection (BYHWI) had been designed to carry out in rat by using single and polypharmacokinetic models for total quanta to ascertain adequate Q-marker...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551646/promotion-of-quality-standard-of-chinese-herbal-medicine-by-the-integrated-and-efficacy-oriented-quality-marker-of-effect-constituent-index
#14
Yin Xiong, Yupiao Hu, Fan Li, Lijuan Chen, Qin Dong, Jiabo Wang, Elizabeth A Gullen, Yung-Chi Cheng, Xiaohe Xiao
BACKGROUND: Multiple constituents have been applied currently as markers to control the quality of Chinese herbal medicine (CHM). However, those constituents are isolated from each other, failed to present their contribution differences to the bioeffect of CHM. Besides, a CHM for different clinic uses is often controlled by the same quality marker (Q-marker), which cannot correlate its efficacies differentially. PURPOSE: The study aims to promote the quality standard of CHM by the integrated and efficacy-oriented Q-marker of Effect-constituent Index (ECI)...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551644/identification-of-quality-markers-of-yuanhu-zhitong-tablets-based-on-integrative-pharmacology-and-data-mining
#15
Ke Li, Junfang Li, Jin Su, Xuefeng Xiao, Xiujuan Peng, Feng Liu, Defeng Li, Yi Zhang, Tao Chong, Haiyu Xu, Changxiao Liu, Hongjun Yang
BACKGROUND: The quality evaluation of traditional Chinese medicine (TCM) formulations is needed to guarantee the safety and efficacy. In our laboratory, we established interaction rules between chemical quality control and biological activity evaluations to study Yuanhu Zhitong tablets (YZTs). Moreover, a quality marker (Q-marker) has recently been proposed as a new concept in the quality control of TCM. However, no appropriate methods are available for the identification of Q-markers from the complex TCM systems...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551643/discovery-of-markers-for-discriminating-the-age-of-cultivated-ginseng-by-using-uhplc-qtof-ms-coupled-with-opls-da
#16
Bao-Ming Huang, Qing-Lin Zha, Ting-Bo Chen, Sheng-Yuan Xiao, Ying Xie, Pei Luo, Ying-Ping Wang, Liang Liu, Hua Zhou
BACKGROUND: Ginseng (Ginseng Radix et Rhizoma, Panax ginseng C.A. Meyer) is gaining more publicity in modern society due to its health benefit and huge value in market. In the practice of grading and pricing of ginseng, the age is one of the major factor influencing the price and grade of ginseng. Therefore, the age discrimination is an important task for the quality control of ginseng. However, the traditional morphological methods are too subjective to be reproductive in discrimination...
March 7, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29631807/quality-transitivity-and-traceability-system-of-herbal-medicine-products-based-on-quality-markers
#17
Changxiao Liu, De-An Guo, Liang Liu
BACKGROUND: Due to a variety of factors to affect the herb quality, the existing quality management model is unable to evaluate the process control. The development of the concept of "quality marker" (Q-marker) lays basis for establishing an independent process quality control system for herbal products. HYPOTHESIS/PURPOSE: To ensure the highest degree of safety, effectiveness and quality process control of herbal products, it is aimed to establish a quality transitivity and traceability system of quality and process control from raw materials to finished herbal products...
March 6, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551647/an-integrated-strategy-for-rapid-discovery-and-identification-of-quality-markers-in-guanxin-kangtai-preparation-using-uhplc-tof-ms-and-multivariate-statistical-analysis
#18
Ting-Bo Chen, Yi-Han Zuo, Geng-Ting Dong, Liang Liu, Hua Zhou
BACKGROUND: Guanxin Kangtai preparation (GXKT), consisting of Panax ginseng, Panax notoginseng and Ilex pubescens, is a new proprietary Chinese medicines under development for treating coronary heart disease. Like other Chinese medicines, the components of GXKT were complex and the bioactive compounds remained unclear. PURPOSE: To discover bioactive compounds as quality markers (Q-markers) for better quality control of GXKT. STUDY DESIGN: Chinese medicines was separated into fractions...
March 6, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551642/quality-markers-of-animal-medicinal-materials-correlative-analysis-of-musk-reveals-distinct-metabolic-changes-induced-by-multiple-factors
#19
Zhi-Shu Tang, Yan-Ru Liu, Yang Lv, Jin-Ao Duan, Shi-Zhong Chen, Jing Sun, Zhong-Xing Song, Xiao-Min Wu, Li Liu
BACKGROUND: Common farming environmental elements, such as longitude, latitude, and altitude, and physiological conditions, such as age and body weight, are thought to influence medicinal animal homeostasis and material quality by altering endocrine functions for primary and secondary metabolite formation. However, the currently available methods for evaluating complex components of traditional Chinese animal medicines have insufficient sensitivity and specificity. PURPOSE: Characterizing the primary/secondary metabolomes of medicinal animals is essential for understanding their material basis, controlling product quality, and reflecting on distribution interactions...
March 6, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551645/the-method-of-quality-marker-research-and-quality-evaluation-of-traditional-chinese-medicine-based-on-drug-properties-and-effect-characteristics
#20
Tiejun Zhang, Gang Bai, Yanqi Han, Jun Xu, Suxiao Gong, Yazhuo Li, Hongbing Zhang, Changxiao Liu
BACKGROUND: Quality of traditional Chinese medicine (TCM) plays a critical role in industry of TCM. Rapid development of TCM pharmaceutical areas is, however, greatly limited, since there are many issues not been resolved, concerning the quality study of TCM. HYPOTHESIS/PURPOSE: Core concept of TCM quality as well as the characteristics of TCM was discussed, in order to guide the quality research and evaluation of TCM, further improve the level of TCM quality control...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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