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Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

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https://www.readbyqxmd.com/read/30217266/effects-of-marantodes-pumilum-kacip-fatimah-on-vaginal-ph-and-expression-of-vacoular-atpase-and-carbonic-anhydrase-in-the-vagina-of-sex-steroid-deficient-female-rats
#1
Nelli Giribabu, Kamarulzaman Karim, Naguib Salleh
BACKGROUND: In sex-steroid deficiency, increased in the pH of vaginal fluid is due to low estrogen levels. HYPOTHESIS: Consumption of Marantodes pumilum leaves helps to ameliorate increased in vaginal fluid pH in sex-steroid deficient condition. PURPOSE: To investigate changes in vaginal fluid pH and expression of proteins that participate in pH changes i.e vacoular (V)-ATPases and carbonic anhydrases (CA) in the vagina following M. pumilum leaves consumption...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217265/metabolic-profiling-of-hypoxia-reoxygenation-injury-in-h9c2-cells-reveals-the-accumulation-of-phytosphingosine-and-the-vital-role-of-dan-shen-in-xin-ke-shu
#2
Lili Sun, Hongmei Jia, Liyan Ma, Meng Yu, Yong Yang, Yang Liu, Hongwu Zhang, Zhongmei Zou
BACKGROUND: Xin-Ke-Shu (XKS), a patent medicine consisting of five commonly used traditional Chinese herbs, is used for the treatment of coronary heart diseases. A previous study showed that XKS has protective effects for ameliorating myocardial ischemia/reperfusion (I/R) injury. PURPOSE: This study was aimed to deeply understand the mechanisms and compatible principle of XKS against hypoxia/reoxygenation (H/R) injury and the contribution of each single herb to the efficacy of XKS...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217264/inhibitory-effect-of-ligustrum-vulgare-leaf-extract-on-the-development-of-neuropathic-pain-in-a-streptozotocin-induced-rat-model-of-diabetes
#3
Monika E Czerwińska, Emilia Gąsińska, Anna Leśniak, Paulina Krawczyk, Anna K Kiss, Marek Naruszewicz, Magdalena Bujalska-Zadrożny
BACKGROUND: Chronic hyperalgesia and allodynia associated with progressive damage of peripheral neurons are the most prevalent complications of diabetes mellitus. Plants belonging to the family of Oleaceae were traditionally used in folk medicine for the management of diabetes. HYPOTHESIS/PURPOSE: The aim of this study was to investigate whether an aqueous extract from the leaves of Ligustrum vulgare (common privet) could be useful to target neuropathic pain in a rat streptozotocin (STZ) model of diabetes...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217263/rhein-augments-atra-induced-differentiation-of-acute-promyelocytic-leukemia-cells
#4
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, SungHoo Jegal, Yookyung Jeong, Jaekyung Cheon, SuJin Koh, Jin Ho Baek, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
BACKGROUND: Rhein (4, 5-dihydroxyanthraquinone-2-carboxylic acid), a natural anthraquinone derivative, is a traditional Chinese herb that has been used as a medication in many Asian countries. It has been used as a laxative and stomach drug for a long time in both China and Korea. It is well-known to have many pharmacological activities, such as anti-cancer, anti-bacterial, anti-fungal, anti-oxidant, anti-atherogenic, anti-angiogenic, anti-fibrosis, anti-inflammatory, hepatoprotective, and nephroprotective properties...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217262/coptidis-rhizoma-inhibits-nlrp3-inflammasome-activation-and-alleviates-renal-damage-in-early-obesity-related-glomerulopathy
#5
Yanlin Ren, Dingkun Wang, Fuer Lu, Xin Zou, Lijun Xu, Kaifu Wang, Wenya Huang, Hao Su, Chu Zhang, Yang Gao, Hui Dong
BACKGROUND: Obese subjects have been considered to be in a state of chronic, low-grade systemic inflammation. Excess fat accumulation and persistent inflammation may promote renal dysfunction, to cause chronic kidney disease (CKD) and even end-stage kidney failure. Coptidis Rhizoma is a classical traditional Chinese herb well known for its hypoglycemic and hypolipidemic properties. The mechanism is partially associated with its anti-inflammatory effect. However, this effect is rarely investigated in obesity and obesity-related glomerulopathy (ORG)...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217261/honokiol-enhances-temozolomide-induced-apoptotic-insults-to-malignant-glioma-cells-via-an-intrinsic-mitochondrion-dependent-pathway
#6
Chung-Ching Chio, Yu-Ting Tai, Mahendravarman Mohanraj, Shing-Hwa Liu, Shun-Tai Yang, Ruei-Ming Chen
BACKGROUND: Temozolomide (TMZ) is a first-line chemotherapeutic drug for malignant gliomas. Nonetheless, TMZ-induced side effects and drug resistance remain challenges. Our previous study showed the suppressive effects of honokiol on growth of gliomas. PURPOSE: This study was further aimed to evaluate if honokiol could enhance TMZ-induced insults toward malignant glioma cells and its possible mechanisms. METHODS: Human U87 MG glioma cells were exposed to TMZ, honokiol, and a combination of TMZ and honokiol...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217260/influence-of-silibinin-and-%C3%AE-%C3%AE-dimethylacrylshikonin-on-chordoma-cells
#7
Jahanafrooz Zohreh, Stallinger Alexander, Anders Ines, Kleinegger Florian, Lohberger Birgit, Durchschein Christin, Bauer Rudolf, Deutsch Alexander, Rinner Beate, Kretschmer Nadine
BACKGROUND: Chordoma, slow growing bone tumours originating from remnants of the notochord, leave affected patients with a median survival of six years. The high recurrence rate of chordoma, together with limited treatment options and bad overall prognosis, make the development of new treatment options urgently necessary. PURPOSE: In this study, the potential of two natural products, silibinin and β-β-dimethylacrylshikonin (DMAS), was tested on clival (MUG-CC1 and UM-Chor1) as well as sacral (MUG-Chor1 and U-CH2) chordoma cell lines...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217259/in-vitro-inhibitory-properties-of-sesquiterpenes-from-chloranthus-serratus-on-cell-motility-via-down-regulation-of-limk1-activation-in-human-breast-cancer
#8
Jianjiang Fu, Juanjuan Yu, Jie Chen, Huanjun Xu, Yongming Luo, Hong Lu
BACKGROUND: LIM kinase 1 plays an important role in tumor cell invasion and metastasis by regulating architecture of actin cytoskeleton, and inhibiting activity of this kinase may be a promising strategy to prevent cancer cells from distant spread. In our previous studies, we found several extracts from the medical herbs in genus Chloranthus to exhibit anti-metastatic effects. PURPOSE: The aim of this study is to find LIMK1 inhibitors from Chloranthus serratus, a medical herb from genus Chloranthus and to evaluate their effects on cell motility...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217258/vitis-amurensis-rupr-a-review-of-chemistry-and-pharmacology
#9
REVIEW
Qing Chen, Lichao Diao, Hua Song, Xuan Zhu
PURPOSE: Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to the Asian continent. It is a highly attractive plant, used widely worldwide. It has been used for several hundred years as a traditional Chinese herb. The review focuses on the botanical description, traditional uses, phytochemistry, and the biological activities of Vitis amurensis Rupr. to evaluate its therapeutic potential uses. METHODS: This review summarizes the published data concerning the botanical aspects, traditional usage, phytochemistry, and pharmacology of Vitis amurensis Rupr...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217257/potent-anti-inflammatory-effects-of-honokiol-in-human-fetal-membranes-and-myometrium
#10
Yasaswi Kaumadha Wijesuriya, Martha Lappas
BACKGROUND: Preterm birth is the most prominent complication attributing to poor pregnancy and neonatal outcome. Infection is most commonly implicated in preterm birth; it initiates a cascade of inflammatory events that leads to the rupture of fetal membranes and spontaneous uterine contractions. Anti-inflammatory agents may thus be a therapeutic approach to prevent the premature rupture of fetal membranes and block contractions. In non-gestational tissues, the polyphenol honokiol has been shown to possess potent anti-inflammatory properties...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217256/renoprotective-effect-of-spirulina-platensis-extract-against-nicotine-induced-oxidative-stress-mediated-inflammation-in-rats
#11
Walid E Zahran, Manal A Emam
BACKGROUND: Nicotine is an important factor in the pathogenesis of renal injury in smokers. PURPOSE: The purpose of the present study was to investigate the renoprotective effect of Spirulina platensis extract (SP) against chronic nicotine administration in rats. METHODS: Nicotine intoxication was induced with 0.5 mg/kg BW. Rats received 500 mg SP/kg BW by gastric gavage over 4 weeks. RESULTS: Our data revealed that nicotine induced renal dysfunction manifested by significant abnormal levels of kidney function markers (creatinine and urea) accompanied by increased levels of oxidative stress biomarker (malondialdehyde) and inflammatory markers (nitric oxide, Interleukin-6 and tumor necrosis factor-α) while antioxidant status as glutathione level and glutathione S-transferase activity were found to be decreased significantly as compared with controls...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30217255/antioxidant-property-of-taraxacum-formosanum-kitam-and-its-antitumor-activity-in-non-small-cell-lung-cancer-cells
#12
John Tung Chien, Ru-Hui Chang, Chia-Hung Hsieh, Chih-Yu Hsu, Chi-Chung Wang
BACKGROUND: Non-small-cell lung cancer (NSCLC) is known to exhibit resistance to various therapeutic agents and become progressively incurable. Taraxacum formosanum is a medicinal Chinese herb that has been clinically used in Taiwan. However, the investigations of the effects of whole plant on lung cancer are limited. PURPOSE: This study evaluated the in vitro antioxidant, antiproliferative, and antimigration effects of the ethanol extract of T. formosanum (ETF)...
October 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195885/effect-of-ginkgo-biloba-extract-761-on-motor-functions-in-permanent-middle-cerebral-artery-occlusion-rats
#13
Gui-Rong Zeng, Shi-da Zhou, Ya-Jie Shao, Miao-Hong Zhang, Li-Ming Dong, Jing-Wei Lv, Hong-Xia Zhang, Ya-Hui Tang, De-Jian Jiang, Xin-Min Liu
BACKGROUND: Ginkgo biloba extract (EGb-761) has been in use to treat variety of ailments including memory loss and emotional disorders usually experienced after ischemic stroke. However, data regarding its protective role in stroke associated motor dysfunction is scarce. PURPOSE: The present work was designed to investigate the long-term effects of EGb-761 on the motor dysfunctions associated with permanent middle cerebral artery occlusion (pMCAO) in rats. STUDY DESIGN/METHODS: Focal ischemic stroke was induced in male Sprague-Dawley rats by pMCAO...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195884/drug-resistance-in-glioblastoma-and-cytotoxicity-of-seaweed-compounds-alone-and-in-combination-with-anticancer-drugs-a-mini-review
#14
REVIEW
Joana Ferreira, Alice Abreu Ramos, Tânia Almeida, Amaya Azqueta, Eduardo Rocha
BACKGROUND: Glioblastomas (GBM) are one of the most aggressive tumor of the central nervous system with an average life expectancy of only 1-2 years after diagnosis, even with the use of advanced treatments with surgery, radiation, and chemotherapy. There are several anticancer drugs with alkylating properties that have been used in the therapy of malignant gliomas. Temozolomide (TMZ) is one of them, widely used even in combination with ionizing radiation. However, the main disadvantage of using these types of drugs in the treatment of GBM is the development of cancer drug resistance...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195883/pyrus-ussuriensis-maxim-leaves-extract-ameliorates-dncb-induced-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#15
KyoHee Cho, Amna Parveen, Min Cheol Kang, Lalita Subedi, Jae Hyuk Lee, Sun Young Park, Mi Rim Jin, Hyeokjun Yoon, Youn Kyoung Son, Sun Yeou Kim
PURPOSE: Pyrus ussuriensis Maxim. has been reported to treat the fever, cough, asthma, and chronic skin disease in Korean Medicine. However, there is no scientific evidence for the use of Pyrus ussuriensis Maxim. Leaves (PUL) extract or its mechanism of action in atopic dermatitis (AD). This study was performed to find the potential therapeutic effects of PUL on the progression of AD using in vitro and in vivo experimental models. METHODS: We examined the effects of PUL on the production of nitric oxide (NO) in RAW 264...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195882/the-effect-of-a-garlic-supplement-on-the-pro-inflammatory-adipocytokines-resistin-and-tumor-necrosis-factor-alpha-and-on-pain-severity-in-overweight-or-obese-women-with-knee-osteoarthritis
#16
Sahar Dehghani, Elham Alipoor, Ahmad Salimzadeh, Mehdi Yaseri, Mostafa Hosseini, Christine Feinle-Bisset, Mohammad Javad Hosseinzadeh-Attar
BACKGROUND: Osteoarthritis (OA) is a prevalent degenerative joint disease, which is associated with chronic and disabling pain. The adipocytokines, resistin and tumor necrosis factor-alpha (TNF-α), might play a role in OA pathogenesis and outcomes. PURPOSE: The aim of this study was, therefore, to assess the anti-inflammatory and analgesic effects of a garlic supplement on serum resistin and TNF-α concentrations and on pain severity in overweight or obese women with knee OA...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195881/zingiber-officinale-extract-administration-diminishes-steroyl-coa-desaturase-gene-expression-and-activity-in-hyperlipidemic-hamster-liver-by-reducing-the-oxidative-and-endoplasmic-reticulum-stress
#17
Mihaela Georgiana Carnuta, Mariana Deleanu, Teodora Barbalata, Laura Toma, Mina Raileanu, Anca Volumnia Sima, Camelia Sorina Stancu
BACKGROUND: Stearoyl CoA desaturases (SCD) are enzymes that convert saturated to monounsaturated fatty acids and have increased activity in hepatic steatosis. PURPOSE: We aimed to investigate the potential of ginger extract (GIN) to modulate the liver SCD1 expression and activity in hyperlipidemic (HL) conditions, in order to lower lipid accumulation in the steatotic liver. STUDY DESIGN/METHODS: Male Golden Syrian hamsters were divided in three groups: (i) fed with standard chow (N), (ii) fed with standard chow plus 3% cholesterol and 15% butter for 21 weeks (HL), (iii) HL treated with GIN (800 µg/kg body weight/day) in the last 5 weeks of fat diet (HL-GIN)...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195880/curcumin-enhances-cisplatin-sensitivity-of-human-nsclc-cell-lines-through-influencing-cu-sp1-ctr1-regulatory-loop
#18
Wei Zhang, Hengfei Shi, Changmai Chen, Ke Ren, Yujun Xu, Xiaoyi Liu, Long He
BACKGROUND: Curcumin is a naturally occurring polyphenol which has been demonstrated to possess diverse biological activities. We previously reported that curcumin is a biologically active copper chelator with antitumor activity. Copper transporter 1 (CTR1) on the plasma membrane of eukaryotic cells mediates both copper as well as anticancer drug cisplatin uptake. PURPOSE: This study aims to investigate whether curcumin enhances cisplatin sensitivity of human non-small cell lung cancer (NSCLC) through influencing Cu-Sp1-CTR1 regulatory loop...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195879/the-anti-anaphylactoid-effects-of-hydroxysafflor-yellow-a-on-the-suppression-of-mast-cell-ca-2-influx-and-degranulation
#19
Rui Liu, Tingting Zhao, Delu Che, Jiao Cao, Jue Wang, Yanni Lv, Pengyu Ma, Yuanyuan Ding, Nana Wang, Xiaoyang Wang, Nan Wang, Jianli Wang, Zijun Gao, Tao Zhang
BACKGROUND: Anaphylaxis is a type of potentially fatal hypersensitivity reaction resulting from the activation of mast cell mediators, especially histamine and lipid mediators. Non-IgE-mediated anaphylaxis can occur because of the direct activation of mast cells. Hydroxysafflor yellow A (HSYA) is the main chemical component of safflower (Carthamus tinctorius) and has been reported to have pharmacological activities. However, the anti-anaphylactoid effect of HSYA has not yet been investigated...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30195878/role-of-the-serotonergic-pathway-in-uterotonic-activity-of-ananas-comosus-l-merr-an-in-vitro-and-in-vivo-study
#20
Faezeh Monji, P Ganesan Adaikan, Lang Chu Lau, Abrar Al-Mahmood Siddiquee, Baharudin Bin Said, Lay-Kien Yang, Yoganathan K, Mahesh A Choolani
BACKGROUND: Ananas comosus (L.) Merr. has been used as a traditional medicine in inducing abortion in many countries. Our previous in vitro experiments showed that the aqueous fraction (F4) of A. comosus extract stimulated the rat and human uterine contractions. PURPOSE: The aim of this study was to identify the bioactive compound and further investigate the molecular mechanism of F4 induced contraction and the in vivo uterotonic effect of F4. MATERIALS AND METHODS: Organ bath studies were employed to compare the stimulatory effect of F4 in non and late pregnant uterine tissue followed by isolation of protein from late pregnant uterine tissue for the western blot analysis...
September 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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