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Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

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https://www.readbyqxmd.com/read/29778318/quality-specifications-for-articles-of-botanical-origin-from-the-united-states-pharmacopeia
#1
Cuiying Ma, Hellen Oketch-Rabah, Nam-Cheol Kim, Maria Monagas, Anton Bzhelyansky, Nandakumara Sarma, Gabriel Giancaspro
BACKGROUND: In order to define appropriate quality of botanical dietary supplements, botanical drugs, and herbal medicines, the United States Pharmacopeia (USP) and the Herbal Medicines Compendium (HMC) contain science-based quality standards that include multiple interrelated tests to provide a full quality characterization for each article in terms of its identity, purity, and content. PURPOSE: To provide a comprehensive description of the pharmacopeial tests and requirements for articles of botanical origin in the aforementioned compendia...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29705003/an-integrated-approach-to-uncover-quality-marker-underlying-the-effects-of-alisma-orientale-on-lipid-metabolism-using-chemical-analysis-and-network-pharmacology
#2
Maoliang Liao, Haihua Shang, Yazhuo Li, Tian Li, Miao Wang, Yanan Zheng, Wenbin Hou, Changxiao Liu
BACKGROUND: Quality control of traditional Chinese medicines is currently a great concern, due to the correlation between the quality control indicators and clinic effect is often questionable. According to the "multi-components and multi-targets" property of TCMs, a new special quality and bioactivity evaluation system is urgently needed. PURPOSE: Present study adopted an integrated approach to provide new insights relating to uncover quality marker underlying the effects of Alisma orientale (AO) on lipid metabolism...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29699843/novel-mathematic-models-for-quantitative-transitivity-of-quality-markers-in-extraction-process-of-the-buyanghuanwu-decoction
#3
Yu-Tian Zhang, Mei-Feng Xiao, Kai-Wen Deng, Yan-Tao Yang, Yi-Qun Zhou, Jin Zhou, Fu-Yuan He, Wen-Long Liu
BACKGROUND: Nowadays, to research and formulate an efficiency extraction system for Chinese herbal medicine, scientists have always been facing a great challenge for quality management, so that the transitivity of Q-markers in quantitative analysis of TCM was proposed by Prof. Liu recently. In order to improve the quality of extraction from raw medicinal materials for clinical preparations, a series of integrated mathematic models for transitivity of Q-markers in quantitative analysis of TCM were established...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29691116/exploring-the-q-marker-of-sweat-soaking-method-processed-radix-wikstroemia-indica-based-on-the-effect-toxicity-chemicals-study
#4
Guo Feng, Yun-Long Chen, Wei Li, Lai-Lai Li, Zeng-Guang Wu, Zi-Jun Wu, Yue Hai, Si-Chao Zhang, Chuan-Qi Zheng, Chang-Xiao Liu, Xin He
BACKGROUND: Radix Wikstroemia indica (RWI), named "Liao Ge Wang" in Chinese, is a kind of toxic Chinese herbal medicine (CHM) commonly used in Miao nationality of South China. "Sweat soaking method" processed RWI could effectively decrease its toxicity and preserve therapeutic effect. However, the underlying mechanism of processing is still not clear, and the Q-markers database for processed RWI has not been established. PURPOSE: Our study is to investigate and establish the quality evaluation system and potential Q-markers based on "effect-toxicity-chemicals" relationship of RWI for quality/safety assessment of "sweat soaking method" processing...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685367/rapid-characterization-of-chemical-markers-for-discrimination-of-moutan-cortex-and-its-processed-products-by-direct-injection-based-mass-spectrometry-profiling-and-metabolomic-method
#5
Chao-Ran Li, Meng-Ning Li, Hua Yang, Ping Li, Wen Gao
BACKGROUND: Processing of herbal medicines is a characteristic pharmaceutical technique in Traditional Chinese Medicine, which can reduce toxicity and side effect, improve the flavor and efficacy, and even change the pharmacological action entirely. It is significant and crucial to perform a method to find chemical markers for differentiating herbal medicines in different processed degrees. PURPOSE: The aim of this study was to perform a rapid and reasonable method to discriminate Moutan Cortex and its processed products, and to reveal the characteristics of chemical components depend on chemical markers...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685366/identifying-quality-markers-from-shengmai-san-protects-against-transgenic-mouse-model-of-alzheimer-s-disease-using-chinmedomics-approach
#6
Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Qing-Yu Zhang, Xi-Jun Wang
BACKGROUND: Shengmai San (SMS), a Chinese classic herbal formula, has been widely used for the treatment of Qi-Yin deficiency syndrome in Asia. Modern pharmacological studies have shown that SMS improves the cognitive function. However, the quality markers (Q-markers) for SMS still need further research. PURPOSE: Using chinmedocmics strategy to systematically evaluate the efficacy of SMS in the treatment of APPswe/PS1dE9 (APP/PS1) transgenic model of Alzheimer's disease (AD) and to discover the efficacy-related Q-markers...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29685365/identify-super-quality-markers-from-prototype-based-pharmacokinetic-markers-of-tangzhiqing-tablet-tzq-based-on-in-vitro-dissolution-permeation-and-in-vivo-absorption-correlations
#7
Ziqiang Li, Jia Liu, Yazhuo Li, Xi Du, Yanfen Li, Ruihua Wang, Chunxiao Lv, Xin He, Baohe Wang, Yuhong Huang, Deqin Zhang
BACKGROUND: A quality marker (Q-marker) is defined as an inherent chemical compound that is used for the quality control of a drug. Its biological activities are closely related to safety and therapeutic effects. Generally, a multiple-component herbal medicine may have many Q-markers. We therefore proposed a concept of "super Q-marker" satisfying both the criterion of Q-markers and PK-markers to be used in more effective quality control of herbal medicine. PURPOSE: The first aim was to find suitable prototype-based PK-markers from Tangzhiqing tablets (TZQ), a Chinese patent medicine...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29576266/exploring-lipid-markers-of-the-quality-of-coix-seeds-with-different-geographical-origins-using-supercritical-fluid-chromatography-mass-spectrometry-and-chemometrics
#8
Jin-Jun Hou, Chun-Mei Cao, Yong-Wei Xu, Shuai Yao, Lu-Ying Cai, Hua-Li Long, Qi-Rui Bi, Yuan-Yuan Zhen, Wan-Ying Wu, De-An Guo
BACKGROUND: Lipids, a group of primary metabolites, could be used as quality markers of Traditional Chinese medicine. PURPOSE: The present study was designed to develop a research method to explore lipid markers of the quality of coix seeds with different geographical origins. STUDY DESIGN: The geographical origins of coix seeds were divided into three regions based on the latitude. A central composite design (CCD test) was used to optimize the chromatographic parameters of supercritical fluid chromatography to obtain optimal lipid profile of coix seed...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29573911/limonene-promotes-osteoblast-differentiation-and-2-deoxy-d-glucose-uptake-through-p38mapk-and-akt-signaling-pathways-in-c2c12-skeletal-muscle-cells
#9
Ilavenil Soundharrajan, Da Hye Kim, Srigopalram Srisesharam, Palaniselvam Kuppusamy, Ravikumar Sivanesan, Ki Choon Choi
BACKGROUND: Limonene is a cyclic monoterpene (CTL) found in citrus fruits and many plant kingdoms. It has attracted attention as potential molecule due to its diverse biological activities. However, molecular mechanism involved in the osteogenic induction of CTL in C2C12 skeletal muscle cells remain unclear. PURPOSE: Skeletal development maintains the bone homeostasis through bone remodeling process. It coordinated between the osteoblast and osteoblast process. Osteoporosis is one of the most common bone diseases caused by a systemic reduction in bone mass...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29555366/application-of-tqsm-polypharmacokinetics-and-its-similarity-approach-to-ascertain-q-marker-by-analyses-of-transitivity-in-vivo-of-five-candidates-in-buyanghuanwu-injection
#10
Yu-Tian Zhang, Mei-Feng Xiao, Qiong Liao, Wen-Long Liu, Kai-Wen Deng, Yi-Qun Zhou, Yu Tang, Fu-Yuan He, Yan-Tao Yang
BACKGROUND: It is well-known that the public still have been facing on a severe issue about the inconsistency of quality and therapeutic efficacy of traditional medicines. Recently, Professor Chang-Xiao Liu has created a new promising concept for identifying relevant quality-markers (Q-marker) from herbs, their formulas and manufacturing products. Therefore, building up a new approach is necessary for us to bridge over quality to efficacy of pharmaceutical products. STUDY DESIGN: In this paper, five candidate Q-markers, astragaloside IV, paeonflorin, amygdalin, tetramethylpyrazine, ferulic acid in Buyanghuanwu injection (BYHWI) had been designed to carry out in rat by using single and polypharmacokinetic models for total quanta to ascertain adequate Q-marker...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551646/promotion-of-quality-standard-of-chinese-herbal-medicine-by-the-integrated-and-efficacy-oriented-quality-marker-of-effect-constituent-index
#11
Yin Xiong, Yupiao Hu, Fan Li, Lijuan Chen, Qin Dong, Jiabo Wang, Elizabeth A Gullen, Yung-Chi Cheng, Xiaohe Xiao
BACKGROUND: Multiple constituents have been applied currently as markers to control the quality of Chinese herbal medicine (CHM). However, those constituents are isolated from each other, failed to present their contribution differences to the bioeffect of CHM. Besides, a CHM for different clinic uses is often controlled by the same quality marker (Q-marker), which cannot correlate its efficacies differentially. PURPOSE: The study aims to promote the quality standard of CHM by the integrated and efficacy-oriented Q-marker of Effect-constituent Index (ECI)...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29551643/discovery-of-markers-for-discriminating-the-age-of-cultivated-ginseng-by-using-uhplc-qtof-ms-coupled-with-opls-da
#12
Bao-Ming Huang, Qing-Lin Zha, Ting-Bo Chen, Sheng-Yuan Xiao, Ying Xie, Pei Luo, Ying-Ping Wang, Liang Liu, Hua Zhou
BACKGROUND: Ginseng (Ginseng Radix et Rhizoma, Panax ginseng C.A. Meyer) is gaining more publicity in modern society due to its health benefit and huge value in market. In the practice of grading and pricing of ginseng, the age is one of the major factor influencing the price and grade of ginseng. Therefore, the age discrimination is an important task for the quality control of ginseng. However, the traditional morphological methods are too subjective to be reproductive in discrimination...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29550178/a-novel-concept-of-q-markers-molecular-connectivity-index
#13
Wen-Long Liu, Xi-Li Zhang, Shi-Qi Fan, Jun-Ping Zhu, Hui-Hui Liang, Yu-Tian Zhang, Mei-Feng Xiao, Yan Zeng, Hong He, Fu-Yuan He, Xiao-Qin Xiao
BACKGROUND: Drugs derived from botany have been playing essential role in both clinical treatment and pharmaceutical industry, unfortunately our worry is still that its quality and therapeutic efficacy are inconsistent. Recently many scientists launched a new project on quality (Q)-marker of medicinal herbs, this study was thus designed to generate a novel concept of quality (Q)-markers: molecular connectivity index (MCI), and to test and verify the new concept of molecular connectivity index (MCI)...
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28040307/polyphyllin-g-induces-apoptosis-and-autophagy-cell-death-in-human-oral-cancer-cells-phytomedicine-23-2016-1545-1554
#14
Ming-Ju Hsieh, Su-Yu Chien, Jen-Tsun Lin, Shun-Fa Yang, Mu-Kuan Chen
No abstract text is available yet for this article.
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28040306/hispolon-from-phellinus-linteus-possesses-mediate-caspases-activation-and-induces-human-nasopharyngeal-carcinomas-cells-apoptosis-through-erk1-2-jnk1-2-and-p38-mapk-pathway-phytomedicine-21-2014-1746-1752
#15
Ming-Ju Hsieh, Su-Yu Chien, Ying-Erh Chou, Chih-Jung Chen, Judy Chen, Mu-Kuan Chen
No abstract text is available yet for this article.
June 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29895497/%C3%AE-n-oxalyl-l-%C3%AE-%C3%AE-diaminopropionic-acid-induces-wound-healing-by-stabilizing-hif-1%C3%AE-and-modulating-associated-protein-expression
#16
Deepshikha Sharma, Preeti Singh, Surya S Singh
BACKGROUND: β-N-oxalyl-L-α,β-diaminopropionic acid (L-ODAP) is a non-protein amino acid with haemostatic property present in Lathyrus sativus. It is considered to be the causative agent of neurolathyrism that occurs upon prolonged overconsumption of Lathyrus sativus seeds. L-ODAP is used as a haemostatic drug in surgical dressings. We previously reported that it can stabilize hypoxia inducible factor (HIF)-1α in normoxic conditions. HYPOTHESIS: We hypothesised that L-ODAP might affect wound healing by modulating cellular proliferation, migration and angiogenesis via HIF-1α stabilization...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29895496/quality-marker-of-tcms-concept-and-applications
#17
EDITORIAL
Chang-Xiao Liu, Liang Liu, De-An Guo
No abstract text is available yet for this article.
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29895495/flavonoids-as-th1-th2-cytokines-immunomodulators-a-systematic-review-of-studies-on-animal-models
#18
REVIEW
Gopalsamy Rajiv Gandhi, Maria Terezinha Santos Leite Neta, Rajiv Gandhi Sathiyabama, Jullyana de Souza Siqueira Quintans, Ana Mara de Oliveira E Silva, Adriano Antunes de Souza Araújo, Narendra Narain, Lucindo José Quintans Júnior, Ricardo Queiroz Gurgel
BACKGROUND: Flavonoids are naturally occurring compounds, extensively distributed in plants. T helper (Th)1 and Th2 cytokines balance plays an essential role in the reaction of inflammatory, allergic and infectious processes and transplantation rejection. PURPOSE: This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions. METHODS: Articles in English published from inception to December 2017 reporting flavonoids with immunomodulatory activity for the management of immune-mediated disorders were acquired from PubMed, EMBASE, Scopus and Web of Science and a animal experiments where Th1 and Th2 cytokines were investigated to assess the outcome of immunoregulatory therapy were included...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29895494/neuroprotective-effect-of-a-standardized-extract-of-centella-asiatica-eca233-in-rotenone-induced-parkinsonism-rats
#19
Narudol Teerapattarakan, Hattaya Benya-Aphikul, Rossarin Tansawat, Oraphan Wanakhachornkrai, Mayuree H Tantisira, Ratchanee Rodsiri
BACKGROUND: Mitochondrial dysfunction and reactive oxygen species (ROS) generation cause dopaminergic neurodegeneration in Parkinson's disease. The neuroprotective approach is a promising strategy to slow disease progression in Parkinson's disease. A standardized extract of Centella asiatica ECa233 has been previously reported to have pharmacological effects in the central nervous system. PURPOSE: This study aimed to determine the neuroprotective effect and mechanisms of ECa233 in rotenone-induced parkinsonism rats...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29895493/isodon-eriocalyx-and-its-bioactive-component-eriocalyxin-b-enhance-cytotoxic-and-apoptotic-effects-of-gemcitabine-in-pancreatic-cancer
#20
L Li, S L Zhao, G G L Yue, T P Wong, J X Pu, H D Sun, K P Fung, P C Leung, Q B Han, C B S Lau, P S Leung
BACKGROUND: Pancreatic cancer, associated with poor prognosis and low survival rate, has been the fourth leading cause of cancer-related death in the US. Although gemcitabine (Gem) is the first-line chemotherapeutic drug in the management of pancreatic cancer, the median survival extension is only 1.5 months, indicating unsatisfactory clinical results. Therefore, exploring agents that can enhance the anti-cancer activity of Gem would be an attractive strategy. PURPOSE: Our previous studies have demonstrated that eriocalyxin b (EriB), an ent‑kaurane diterpenoid isolated from Isodon eriocalyx (Dunn...
May 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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