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Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

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https://www.readbyqxmd.com/read/28732813/a-randomized-double-blind-placebo-controlled-study-on-the-anti-haemostatic-effects-of-curcuma-longa-angelica-sinensis-and-panax-ginseng
#1
Foon Yin Fung, Wan Hui Wong, Seng Kok Ang, Hwee Ling Koh, Mei Ching Kun, Lai Heng Lee, Xiaomei Li, Heng Joo Ng, Chuen Wen Tan, Yan Zhao, Yeh Ching Linn
PURPOSE: Herbs with "blood-activating" properties by traditional medicine theory often raise concerns for their possible anti-platelet or anticoagulation effects based on reports from in vitro studies. Such herbs have been implicated for bleeding manifestations based on only anecdotal reports. In particular, the combination of such herbs with anti-platelet agents is often empirically advised against despite lack of good clinical evidence. Here we studied 3 commonly used herbal preparations Curcuma longa, Angelica sinensis and Panax ginseng on their respective anti-platelet and anticoagulation effect, alone and in combination with aspirin...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732812/extracts-and-compounds-active-on-trp-ion-channels-from-waldheimia-glabra-a-ritual-medicinal-plant-from-himalaya
#2
Annamaria Giorgi, Angela Bassoli, Gigliola Borgonovo, Sara Panseri, Alessandra Manzo, Daniela Pentimalli, Aniello Schiano Moriello, Luciano De Petrocellis
BACKGROUND: Waldheimia glabra (Decne.) Regel is a wild plant from the Himalayan Mountains, commonly known as Smooth Ground Daisy. This plant is traditionally used by local populations in religious rituals (incense) or in traditional herbal medicine to treat skin diseases, headache, joint pain and fever. In literature few data are available on the investigation of this aromatic plant. PURPOSE: The present work aims at deepening knowledge about the chemical composition of W...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732811/kaurenoic-acid-activates-tgf-%C3%AE-signaling
#3
Kyun Ha Kim, Jin Woo Han, Sung-Ki Jung, Bum-Joon Park, Chang Woo Han, Myungsoo Joo
BACKGROUND: Kaurenoic acid (ent-kaur-16-en-19-oic acid: KA) is a key constituent found in the roots of Aralia continentalis Kitagawa (Araliaceae) that has been used for treating rheumatism in traditional Asian medicine. HYPOTHESIS: Although KA was reported to suppress inflammation by activating Nrf2, the anti-inflammatory function of KA is less characterized. Given the complex nature of the inflammatory response and the critical role of TGF-β in resolving inflammation, we hypothesized that KA suppresses inflammatory response by activating TGF-β signaling...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732810/the-interaction-of-auraptene-and-other-oxyprenylated-phenylpropanoids-with-glucose-transporter-type-4
#4
Salvatore Genovese, Hitoshi Ashida, Yoko Yamashita, Tomoya Nakgano, Masaki Ikeda, Shirasaya Daishi, Francesco Epifano, Vito Alessandro Taddeo, Serena Fiorito
BACKGROUND: Glucose transporter 4 (GLUT4) is firmly established to play a pivotal role in glucose metabolism and in particular in modulating the insulin-stimulated glucose transport in several tissues, such as skeletal muscle and adipose tissue. Stimulation of GLUT4 by insulin results in its translocation to the plasma membrane, activation of several kinases, and finally in a large glucose influx into cells. PURPOSE: In this study we investigated the modulating properties of four biologically active oxyprenylated ferulic acid and umbelliferone derivatives and of their unprenylated parent compounds on GLUT-4 mediated glucose uptake and translocation...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732809/oleacein-may-inhibit-destabilization-of-carotid-plaques-from-hypertensive-patients-impact-on-high-mobility-group-protein-1
#5
Agnieszka Filipek, Monika E Czerwińska, Anna K Kiss, Jerzy A Polański, Marek Naruszewicz
BACKGROUND: In patients with hypertension the haemorrhage into carotid atherosclerotic plaque increases risk of plaque destabilization and rupture. Our previous study showed that oleacein, a secoiridoid present in extra virgin olive oil, enhanced uptake of haemoglobin-haptoglobin complex and change macrophage phenotype from pro-inflammatory M1 to anti-inflammatory M2. PURPOSE: The aim this study was to investigate a potential role of oleacein in attenuation of carotid plaque destabilisation ex vivo...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732808/safety-evaluation-of-astragalus-extract-mixture-ht042-and-its-constituent-herbs-in-sprague-dawley-rats
#6
Jungbin Song, Donghun Lee, Byoungjae Min, Jin-Sook Bae, Gyu Tae Chang, Hocheol Kim
BACKGROUND: Astragalus extract mixture HT042 is a combination of three standardized extracts from Astragalus membranaceus root, Eleutherococcus senticosus stem, and Phlomis umbrosa root, which has proven to stimulate children's height growth. PURPOSE: The aim of this study was to demonstrate the safety of HT042 and its three constituent herbs when administered orally. METHODS: Acute and sub-chronic oral toxicity studies were conducted using male and female Sprague-Dawley rats...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732807/pharmacology-and-toxicology-of-%C3%AE-and-%C3%AE-asarone-a-review-of-preclinical-evidence
#7
REVIEW
Ranjithkumar Chellian, Vijayapandi Pandy, Zahurin Mohamed
BACKGROUND: Asarone is one of the most researched phytochemicals and is mainly present in the Acorus species and Guatteria gaumeri Greenman. In preclinical studies, both α- and β-asarone have been reported to have numerous pharmacological activities and at the same time, many studies have also revealed the toxicity of α- and β-asarone. PURPOSE: The purpose of this comprehensive review is to compile and analyze the information related to the pharmacokinetic, pharmacological, and toxicological studies reported on α- and β-asarone using preclinical in vitro and in vivo models...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732806/artemisia-annua-dried-leaf-tablets-treated-malaria-resistant-to-act-and-i-v-artesunate-case-reports
#8
Nsengiyumva Bati Daddy, Luc Malemo Kalisya, Pascal Gisenya Bagire, Robert L Watt, Melissa J Towler, Pamela J Weathers
BACKGROUND: Dried leaf Artemisia annua (DLA) has shown efficacy against Plasmodium sp. in rodent studies and in small clinical trials. Rodent malaria also showed resiliency against the evolution of artemisinin drug resistance. PURPOSE: This is a case report of a last resort treatment of patients with severe malaria who were responding neither to artemisinin combination therapy (ACT) nor i.v. artesunate. STUDY DESIGN: Of many patients treated with ACTs and i...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732805/capillarisin-attenuates-exercise-induced-muscle-damage-through-mapk-and-nf-%C3%AE%C2%BAb-signaling
#9
Minjee Kim, Jaemoo Chun, Hyun Ah Jung, Jae Sue Choi, Yeong Shik Kim
BACKGROUND: Intense exercise has the potential to increase oxidative stress and cause muscle damage. Mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) are two major regulators of gene transcription in response to oxidative stress in the skeletal muscle. Pure capillarisin (CAP) isolated from Artemisia capillaris Thunberg is known to have antioxidant and anti-inflammatory effects. HYPOTHESIS/PURPOSE: We hypothesized CAP to exert antioxidant activity against exercise-induced oxidative stress and suppress acute inflammatory response...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732804/interactions-of-a-prenylated-flavonoid-from-dalea-elegans-with-fluconazole-against-azole-resistant-candida-albicans
#10
Sebastián Barceló, Mariana Peralta, Maximiliano Calise, Soledad Finck, Gabriela Ortega, Roberto A Diez, José Luis Cabrera, Cristina Pérez
BACKGROUND: The prenylated flavonoid 2', 4'-dihydroxy-5'-(1'″, 1'″-dimethylallyl)-8-prenylpinocembrin (8PP, formerly 6PP) shows antifungal activity, inhibits rhodamine 6G efflux and reverses fluconazole (FCZ) resistance in azole-resistant Candida albicans overexpressing cdr1, cdr2 and mdr1 transporters. PURPOSE AND DESIGN: In this paper, we tried to characterize 8PP in vitro interactions on the cell growth and lethality of C. albicans. We also initiated preliminary in vivo toxicological studies on mice...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732803/-7-s-hydroxymatairesinol-protects-against-tumor-necrosis-factor-%C3%AE-mediated-inflammation-response-in-endothelial-cells-by-blocking-the-mapk-nf-%C3%AE%C2%BAb-and-activating-nrf2-ho-1
#11
Di Yang, Chen-Xi Xiao, Zheng-Hua Su, Meng-Wei Huang, Ming Qin, Wei-Jun Wu, Wan-Wan Jia, Yi-Zhun Zhu, Jin-Feng Hu, Xin-Hua Liu
BACKGROUND: Endothelial inflammation is an increasingly prevalent condition in the pathogenesis of many cardiovascular diseases. (-)-7(S)-hydroxymatairesinol (7-HMR), a naturally occurring plant lignan, possesses both antioxidant and anti-cancer properties and therefore would be a good strategy to suppress tumor necrosis factor-α (TNF-α)-mediated inflammation in vascular endothelial cells (VECs). PURPOSE: The objective of this study is to evaluate for its anti-inflammatory effect on TNF-α-stimulated VECs and underling mechanisms...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28732802/carica-papaya-ameliorates-allergic-asthma-via-down-regulation-of-il-4-il-5-eotaxin-tnf-%C3%AE-nf-%C3%A4-b-and-inos-levels
#12
Asma Inam, Muhammad Shahzad, Arham Shabbir, Hira Shahid, Khadija Shahid, Aqeel Javeed
BACKGROUND: Natural products have a prime importance as an essential source for new drug discovery. Carica papaya leaves (CPL) have been used to treat inflammation in traditional system of medicine. AIM/HYPOTHESIS: Current study evaluates the anti-inflammatory and immunomodulatory effects of CPL extract using mouse model of ovalbumin- (OVA) induced allergic asthma. METHODS: All the mice were intraperitoneally sensitized and subsequently given intranasal challenge with OVA except the control group...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28606513/serum-metabolomics-analysis-reveals-that-obvious-cardioprotective-effects-of-low-dose-sini-decoction-against-isoproterenol-induced-myocardial-injury-in-rats
#13
Jun Zhou, Xiaoqiong Ma, Min Shi, Cuiwei Chen, Yue Sun, Jingjing Li, Youxiang Xiong, Junjie Chen, Fanzhu Li
BACKGROUND: Sini decoction (SND) is used for cardiovascular disease over thousands of years in China. However, it is still lacking of dose-response relationship of SND in cardiovascular disease at the metabolic level. PURPOSE: The present study is designed to explore the cardioprotective effects of different dosages of SND pretreatment on the isoproterenol (ISO)-induced myocardial injury and elucidate the mechanism underlying this protective effect. METHODS: The cardioprotective effects of different dosages of SND pretreatment on the isoproterenol-induced myocardial injury were compared through a serum metabolomics approach based on ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS)...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28606512/heme-oxygenase-1-mediates-anti-adipogenesis-effect-of-raspberry-ketone-in-3t3-l1-cells
#14
Yung-Chieh Tsai, Bo-Cheng Yang, Wen-Huang Peng, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng
BACKGROUND: Obesity is caused by excessive accumulation of body fat and is closely related to complex metabolic diseases. Raspberry ketone (RK), a major aromatic compound in red raspberry, was recently reported to possess anti-obesity effects. However, its mechanisms are unclear. AIM: Adipogenesis plays a critical role in obesity and, therefore, this study aimed to investigate the effect and mechanisms of action of RK on adipogenesis in 3T3-L1 preadipocytes. MATERIALS AND METHODS: 3T3-L1 preadipocytes were differentiated in medium containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthine...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28606511/the-escop-monographs-for-universities
#15
LETTER
Liselotte Krenn
No abstract text is available yet for this article.
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28606510/in-vitro-inhibitory-mechanisms-and-molecular-docking-of-1-s-1-acetoxychavicol-acetate-on-human-cytochrome-p450-enzymes
#16
A K M Mahmudul Haque, Kok Hoong Leong, Yoke Lin Lo, Khalijah Awang, Noor Hasima Nagoor
BACKGROUND: The compound, 1'-S-1'-acetoxychavicol acetate (ACA), isolated from the rhizomes of a Malaysian ethno-medicinal plant, Alpinia conchigera Griff. (Zingiberaceae), was previously shown to have potential in vivo antitumour activities. In the development of a new drug entity, potential interactions of the compound with the cytochrome P450 superfamily metabolizing enzymes need to be ascertain. PURPOSE: The concomitant use of therapeutic drugs may cause potential drug-drug interactions by decreasing or increasing plasma levels of the administered drugs, leading to a suboptimal clinical efficacy or a higher risk of toxicity...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545672/enhancement-of-apoptotic-activities-on-brain-cancer-cells-via-the-combination-of-%C3%AE-tocotrienol-and-jerantinine-a
#17
Ibrahim Babangida Abubakar, Kuan-Hon Lim, Toh-Seok Kam, Hwei-San Loh
BACKGROUND: γ-Tocotrienol, a vitamin E isomer possesses pronounced in vitro anticancer activities. However, the in vivo potency has been limited by hardly achievable therapeutic levels owing to inefficient high-dose oral delivery which leads to subsequent metabolic degradation. Jerantinine A, an Aspidosperma alkaloid, originally isolated from Tabernaemontana corymbosa, has proved to possess interesting anticancer activities. However, jerantinine A also induces toxicity to non-cancerous cells...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545671/trypanosuppresive-effects-of-ellagic-acid-and-amelioration-of-the-trypanosome-associated-pathological-features-coupled-with-inhibitory-effects-on-trypanosomal-sialidase-in-vitro-and-in-silico
#18
Raphael Aminu, Mohammed Auwal Ibrahim, Md Atiar Rahman, Raju Dash, Ismaila Alhaji Umar
BACKGROUND: The search for novel antitrypanosomal agents had previously led to the isolation of ellagic acid as a bioactive antitrypanosomal compound using in vitro studies. However, it is not known whether this compound will elicit antitrypanosomal activity in in vivo condition which is usually the next step in the drug discovery process. PURPOSE: Herein, we investigated the in vivo activity of ellagic acid against bloodstream form of Trypanosoma congolense and its ameliorative effects on trypanosome-induced anemia and organ damage as well as inhibitory effects on trypanosomal sialidase...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545670/inhibitory-mechanism-of-five-natural-flavonoids-against-murine-norovirus
#19
Dong Joo Seo, Changsun Choi
BACKGROUND: Human noroviruses (HuNoV), which are responsible for acute gastroenteritis, are becoming a serious public health concern worldwide. Since no effective antiviral drug or vaccine for HuNoV has been developed yet, some natural extracts and their active components have been investigated for their ability to inhibit noroviruses. However, their exact antiviral mechanisms have not been investigated. PURPOSE: This study was performed to investigate the expression of interferon (IFN)-α, IFN-λ, tumor necrosis factor-α (TNF-α), Mx, and zinc finger CCCH type antiviral protein 1 (ZAP), 2'-5' oligo (A) synthetase (OAS), and inducible nitric oxide synthase (iNOS) in RAW 264...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545669/are-russian-propolis-ethanol-extracts-the-future-for-the-prevention-of-medical-and-biomedical-implant-contaminations
#20
Ashwin Ambi, Julia Bryan, Katherine Borbon, Daniel Centeno, Tianchi Liu, Tung Po Chen, Thomas Cattabiani, Christian Traba
BACKGROUND: Most studies reveal that the mechanism of action of propolis against bacteria is functional rather than structural and is attributed to a synergism between the compounds in the extracts. HYPOTHESIS/PURPOSE: Propolis is said to inhibit bacterial adherence, division, inhibition of water-insoluble glucan formation, and protein synthesis. However, it has been shown that the mechanism of action of Russian propolis ethanol extracts is structural rather than functional and may be attributed to the metals found in propolis...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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