Keitaro Yamanouchi, Shizuka Kato, Yukie Tanaka, Masanari Ikeda, Yukina Oshimo, Takanori Shiga, Kei Hatamoto, James Chambers, Takuya Imamura, Ryuji Hiramatsu, Kazuyuki Uchida, Fuko Matsuda, Takashi Matsuwaki, Tetsuya Kohsaka
The mammalian X chromosome exhibits enrichment in genes associated with germ cell development. Previously, we generated a rat model of Becker muscular dystrophy (BMD) characterized by an in-frame mutation in the dystrophin gene, situated on the X chromosome and responsible for encoding a protein crucial for muscle integrity. Male BMD rats are infertile owing to the absence of normal spermatids in the epididymis. Within the seminiferous tubules of BMD rats, elongated spermatids displayed abnormal morphology...
January 19, 2024: Journal of Reproduction and Development