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Cancer Control: Journal of the Moffitt Cancer Center

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https://www.readbyqxmd.com/read/30086666/association-between-positive-cultures-during-admission-and-1-year-mortality-in-patients-with-cancer-receiving-perioperative-intensive-care
#1
Hsiu-Yin Chiang, Tung-Han Wu, Chiann-Yi Hsu, Wen-Cheng Chao
The number of patients with cancer being admitted to intensive care units (ICUs) is increasing worldwide, and these patients are vulnerable to infection. This study aimed to address the long-term impact of positive cultures during admission on 1-year mortality among patients with cancer who received perioperative intensive care. This retrospective cohort study enrolled adult patients with cancer who were admitted to ICUs and received surgery during 2011 to 2016 at a tertiary hospital in central Taiwan. Cancer-related data were retrieved from the cancer registry, and data during ICU admissions were obtained from the electronic medical records...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/30037277/human-plasma-levels-of-vascular-endothelial-growth-factor-matrix-metalloproteinase-9-and-tissue-inhibitor-of-matrix-metalloproteinase-1-and-their-applicability-as-tumor-markers-in-diagnoses-of-cervical-cancer-based-on-roc-analysis
#2
Monika Zajkowska, Monika Zbucka-Krętowska, Iwona Sidorkiewicz, Emilia Lubowicka, Grażyna Ewa Będkowska, Ewa Gacuta, Maciej Szmitkowski, Sławomir Ławicki
Cervical cancer (CC) remains a major diagnostic problem. The introduction of human papillomavirus vaccination significantly reduced the number of new cases; however, the search for new methods that would earlier indicate the development of cancerous changes is vital. The aim of this study was to investigate the diagnostic power of those parameters in comparison to Cancer Antigen 125 (CA 125) and Squamous Cell Carcinoma Antigen (SCC-Ag) in patients with CC and in relation to the control group. The study included 100 patients with CC and 50 healthy women...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/30032643/lenvatinib-a-promising-molecular-targeted-agent-for-multiple-cancers
#3
Koichi Suyama, Hirotaka Iwase
Lenvatinib is a small-molecule tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet-derived growth factor receptor α (PDGFRα), stem cell factor receptor (KIT), and rearranged during transfection (RET). These receptors are important for tumor angiogenesis, and lenvatinib inhibits tumor angiogenesis by inhibiting function of these receptors. Phase I trials of lenvatinib were conducted at the same time in Japan, Europe, and the United States, and tumor shrinkage effects were observed in thyroid cancer, endometrial cancer, melanoma, renal cell carcinoma, sarcoma, and colon cancer...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/30027755/bladder-cancer-in-lebanon-incidence-and-comparison-to-regional-and-western-countries
#4
Najla A Lakkis, Salim M Adib, Ghassan N Hamadeh, Rana T El-Jarrah, Mona H Osman
Lebanon has one of the highest estimated age-standardized incidence rate (ASR(w)) of bladder cancer (BC) worldwide. The aim of this study is to analyze the incidence rates for BC in Lebanon over a period of 7 years and to compare them to the rates in other countries. Data were obtained from the Lebanese National Cancer Registry for the currently available years 2005 to 2011. The calculated ASR(w) and age-specific rates were expressed as per 100 000 population. From 2005 to 2011, BC has been ranked as the third most common cancer in Lebanon...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/30021466/immortal-time-bias-in-observational-studies-of-time-to-event-outcomes-assessing-effects-of-postmastectomy-radiation-therapy-using-the-national-cancer-database
#5
Parul Agarwal, Erin Moshier, Meng Ru, Nisha Ohri, Ronald Ennis, Kenneth Rosenzweig, Madhu Mazumdar
The objectives of this study are to illustrate the effects of immortal time bias (ITB) using an oncology outcomes database and quantify through simulations the magnitude and direction of ITB when different analytical techniques are used. A cohort of 11 626 women who received neoadjuvant chemotherapy and underwent mastectomy with pathologically positive lymph nodes were accrued from the National Cancer Database (2004-2008). Standard Cox regression, time-dependent (TD), and landmark models were used to compare overall survival in patients who did or did not receive postmastectomy radiation therapy (PMRT)...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29925247/anal-cancer-prevention-perspectives-among-foreign-born-latino-hiv-infected-gay-and-bisexual-men
#6
Alexis M Koskan, Madeline Fernandez-Pineda
This study explores understanding of primary and secondary prevention of anal cancer among human immunodeficiency virus (HIV)-infected foreign-born Latino gay and bisexual men (GBM). Between August 2015 and December 2016, researchers conducted 33 in-depth, semi-structured interviews with HIV-infected foreign-born Latino GBM. Interview questions sought to determine participants' knowledge and perceived barriers and facilitators to primary and secondary prevention of anal cancer. Researchers analyzed interview transcripts using a qualitative content analysis approach...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29895186/quality-of-reporting-in-oncology-randomized-controlled-trials-from-2011-to-2015
#7
Huiyun Zhu, Si Chen, Pei Xie, Geliang Yang, Zhenqiang Zhong, Huiqing Zhang, Yiqi Du
Randomized controlled trials (RCTs) are important for evidence-based medicine; however, their quality of reporting remains to be evaluated. The aim of this study was to assess the quality of the report concerning solid tumor medication. Articles were searched in PubMed to identify all oncology phase III RCTs published from 2011 to 2015, and the results were classified manually through Endnote X7.0 software. Registration rate, primary end point (PEP) consistency, positive result rate, enrollment time point, outcome feedback in the registry, and publish time zone were extracted and assessed...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29843532/increased-golm1-expression-independently-predicts-unfavorable-overall-survival-and-recurrence-free-survival-in-lung-adenocarcinoma
#8
Xi Liu, Lei Chen, Tao Zhang
Golgi membrane protein 1 (GOLM1) is a transmembrane glycoprotein of the Golgi cisternae, which is implicated in carcinogenesis of multiple types of cancer. In this study, using data from the Gene Expression Omnibus and The Cancer Genome Atlas, we compared the expression of GOLM1 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) and studied its prognostic value in terms of overall survival (OS) and recurrence-free survival (RFS) in these 2 subtypes of non-small cell lung cancer (NSCLC). Results showed that GOLM1 was significantly upregulated in both LUAD and LUSC tissues compared to the normal controls...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29781295/impact-of-statin-use-on-recurrence-or-survival-after-surgical-curative-resection-of-non-small-cell-lung-cancer
#9
Tak Kyu Oh, Kwhanmien Kim, Sanghoon Jheon, Jaebong Lee, Sang-Hwan Do, Jung-Won Hwang, Hyo Jin Kim, In-Ae Song
Statins are known for their anticancer effects, and many studies have shown the effectiveness of statins for cancer prevention and improvement of cancer-related long-term oncologic outcome. However, their effectiveness on recurrence or survival of non-small cell lung cancer (NSCLC) after curative resection remains unknown. This was a retrospective cohort study that assessed the medical records of patients who were diagnosed with NSCLC and treated with curative resection at a tertiary care hospital between August 2003 and July 2012...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29779412/primary-gastric-lymphoma-epidemiology-clinical-diagnosis-and-treatment
#10
Luis Miguel Juárez-Salcedo, Lubomir Sokol, Julio C Chavez, Samir Dalia
Primary gastric lymphoma (PGL) is the most common extranodal non-Hodgkin lymphoma and represents a wide spectrum of disease, ranging from indolent low-grade marginal zone lymphoma or mucosa-associated lymphoid tissue (MALT) lymphoma to aggressive diffuse large B-cell lymphoma. The PGL is a relatively rare cancer and easily misdiagnosed due to its unspecific symptoms of the digestive tract. The medical literature and ongoing clinical trials were reviewed on the clinical presentation, diagnosis, prognosis, prevention, and treatment of PGL...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29761723/knowledge-and-attitudes-regarding-hpv-and-vaccination-among-chinese-women-aged-20-to-35-years-in-fujian-province-a-cross-sectional-study
#11
Lihua Chen, Yiyi Song, Guanyu Ruan, Qiaoyu Zhang, Fen Lin, Jun Zhang, Ting Wu, Jian An, Binhua Dong, Pengming Sun
The use of the human papillomavirus (HPV) vaccine was recently approved in Mainland China. This study determined the knowledge and attitudes of young women aged 20 to 35 years in Fujian Province, China, with regard to HPV and vaccination and explored the potential factors influencing their attitudes toward HPV vaccination. This was a cross-sectional study that collected data regarding the knowledge on and attitudes toward HPV and vaccination using questionnaires. Furthermore, the prevalence of HPV was determined from the sampled participants...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29739245/long-term-oncologic-outcomes-for-patients-undergoing-volatile-versus-intravenous-anesthesia-for-non-small-cell-lung-cancer-surgery-a-retrospective-propensity-matching-analysis
#12
Tak Kyu Oh, Kwhanmien Kim, Sanghoon Jheon, Jaebong Lee, Sang-Hwan Do, Jung-Won Hwang, In-Ae Song
Propofol-based total intravenous anesthesia (TIVA) has been reported to improve long-term outcome following cancer surgery, when compared with inhalation agents. However, such investigational reports are still controversial, and no studies have been conducted in relation to non-small cell lung cancer (NSCLC) surgery. The present study aimed to compare the favorable effects of TIVA versus inhalation agents on recurrence-free survival and overall survival after curative resection of NSCLC. This retrospective cohort study examined medical records of the patients who were diagnosed with NSCLC and underwent curative resection at Seoul National University Bundang Hospital from August 2003 to July 2012...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29716399/informed-consent-in-pediatric-oncology-a-systematic-review-of-qualitative-literature
#13
Ghiath Alahmad
OBJECTIVE: Obtaining informed consent in pediatric cancer research can be subject to important ethical challenges because of the difficulty in distinguishing between care and research, which are interrelated. Pediatric oncologists also often conduct research, such as clinical trials, on their own patients, which may influence voluntary informed consent. This review aims to determine the ethical issues encountered in obtaining informed consent in pediatric oncology by identifying and summarizing the findings of existing qualitative studies on this topic...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29651883/lncrna-dancr-promotes-lung-cancer-by-sequestering-mir-216a
#14
Qiang Zhen, Li-Na Gao, Ren-Feng Wang, Wei-Wei Chu, Ya-Xiao Zhang, Xiao-Jian Zhao, Bao-Lei Lv, Jia-Bao Liu
BACKGROUND: Long noncoding RNAs (lncRNAs) are a new class of cancer regulators. Here, we aimed to investigate the diagnostic and therapeutic values of an lncRNA, differentiation antagonizing noncoding RNA (DANCR), in lung cancer. METHODS: Real-time polymerase chain reaction was used to compare DANCR levels in normal and cancerous lung tissues as well as lung cancer cells. Lentiviral transduction was used to induce DANCR overexpression or silencing in vitro, followed by monitoring cell proliferation, colony formation, and changes in microRNA-216a (miR-216a) expression...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29606020/hepatitis-b-reactivation-in-the-treatment-of-non-hodgkin-lymphoma
#15
Matthew Kelling, Lubomir Sokol, Samir Dalia
Chronic active hepatitis B infection (HBV) has been implicated in lymphomagenesis of non-Hodgkin lymphoma (NHL). Treatment of cancer including NHL with chemotherapy or immunotherapy can lead to HBV reactivation in previously infected patients. Serological testing of HBV prior to initiation of this therapy is recommended by several national and international medical agencies and expert panels. Patients with positive hepatitis B surface antigen (HBsAg) and anti-hepatitis B core antibody (anti-HBc ab) need to start antiviral therapy with entecavir or tenofovir prior to initiation of chemotherapy or immunotherapy and continue this treatment for 6 to 12 months after completion of cancer therapy to avoid late HBV reactivation...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29592528/barriers-and-facilitating-factors-for-research-involvement-in-cancer-centers-a-survey-of-colorectal-cancer-center-coordinators-in-germany-austria-and-switzerland
#16
Christoph Kowalski, Stefan Post, Thomas Seufferlein, Stefan R Benz, Julia Ferencz, Simone Wesselmann
Improvements in health care depend on research involving health-care providers (HCPs) and health-care organizations (HCOs). Existing research suggests that involvement in research studies is still much lower than it could be. This study investigates factors that may impede or facilitate research involvement. A standardized online questionnaire was used to carry out a survey, in 3 countries, of key informants in colorectal cancer centers that hold certification in accordance with the requirements of the German Cancer Society...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29582668/robot-assisted-versus-laparoscopy-assisted-proximal-gastrectomy-for-early-gastric-cancer-in-the-upper-location-comparison-of-oncological-outcomes-surgical-stress-and-nutritional-status
#17
Kecheng Zhang, Xiaohui Huang, Yunhe Gao, Wenquan Liang, Hongqing Xi, Jianxin Cui, Jiyang Li, Minghua Zhu, Guoxiao Liu, Huazhou Zhao, Chong Hu, Yi Liu, Zhi Qiao, Bo Wei, Lin Chen
BACKGROUND: An increasing amount of attention has been paid to minimally invasive function-preserving gastrectomy, with an increase in incidence of early gastric cancer in the upper stomach. This study aimed to compare oncological outcomes, surgical stress, and nutritional status between robot-assisted proximal gastrectomy (RAPG) and laparoscopy-assisted proximal gastrectomy (LAPG). METHODS: Eighty-nine patients were enrolled in this retrospective study between November 2011 and December 2013...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29480026/in-search-of-a-gold-standard-patient-reported-outcome-measure-for-use-in-chemotherapy-induced-peripheral-neuropathy-clinical-trials
#18
Ellen M Lavoie Smith, Robert Knoerl, James J Yang, Grace Kanzawa-Lee, Deborah Lee, Celia M Bridges
PURPOSE: To test a reduced version-CIPN15-of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy scale (QLQ-CIPN20) to establish a possible gold-standard patient-reported outcome measure for chemotherapy-induced peripheral neuropathy (CIPN). METHODS: Using a prospective, longitudinal, case-control design, patients (n = 121) receiving neurotoxic chemotherapy completed the CIPN15 at baseline and 12 weeks and underwent objective neurological assessment using the 5-item Total Neuropathy Score-Clinical (TNSc)...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29480024/dose-escalation-of-vitamin-d-3-yields-similar-cryosurgical-outcome-to-single-dose-exposure-in-a-prostate-cancer-model
#19
Kimberly L Santucci, John M Baust, Kristi K Snyder, Robert G Van Buskirk, John G Baust
Vitamin D3 (VD3 ) is an effective adjunctive agent, enhancing the destructive effects of freezing in prostate cancer cryoablation studies. We investigated whether dose escalation of VD3 over several weeks, to model the increase in physiological VD3 levels if an oral supplement were prescribed, would be as or more effective than a single treatment 1 to 2 days prior to freezing. PC-3 cells in log phase growth to model aggressive, highly metabolically active prostate cancer were exposed to a gradually increasing dose of VD3 to a final dose of 80 nM over a 4-week period, maintained for 2 weeks at 80 nM, and then exposed to mild sublethal freezing temperatures...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29353494/primary-liver-cancers-part-2-progression-pathways-and-carcinogenesis
#20
Kun Jiang, Barbara A Centeno
Hepatocellular carcinoma (HCC) and primary intrahepatic cholangiocarcinoma (ICC) have been increasing in incidence worldwide and are leading causes of cancer death. Studies of the molecular alterations leading to these carcinomas provide insights into the key mechanisms involved. A literature review was conducted to identify articles with information relevant to current understanding of the etiologies and molecular pathogenesis of HCC and ICC. Chronic inflammatory diseases are the key etiological risk factors for both HCC and ICC, although other diseases play a role, and for many ICCs, an underlying risk factor is not identified...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
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