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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://www.readbyqxmd.com/read/29517209/medulloblastoma-with-extensive-nodularity-shh-medulloblastoma
#1
Iga Alicja Fudyma, Nitin R Wadhwani
Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old. Medulloblastoma occurs in the 4th ventricle and usually presents with symptoms of increased intracranial pressure (headaches, nausea, vomiting) and signs of obstructive hydrocephalus. Medulloblastoma is both histologically and genetically defined with prognosis that depends on classification...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517208/asymptomatic-uterus-like-mass-ulm-of-the-extraperitoneal-space-a-case-report-of-a-rare-finding-with-unusual-clinical-presentation-and-review-of-the-literature
#2
Konrad Muzykiewicz, Paweł Majchrzak, Ewa Iwańska, Wiktor Szatkowski, Piotr Szubel, Kazimierz Karolewski
The paper presents a case of a uterus-like mass (ULM), a rare type of tumour of the female reproductive system, which did not present any clinical symptoms described in other cases of ULMs. There are 35 reported cases of this type of tumour. It is defined as a lesion composed of smooth muscle-like stromal cells with a central cavity lined with endometrial type epithelium. There are three theories on the pathogenesis of ULMs which we discuss along with clinical presentation, diagnostic features, treatment options and potential oncological implications of this type of tumour, based on our case, and the review of the literature...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517207/soft-tissue-metastasis-of-mediastinal-non-functioning-paraganglioma-with-unusual-ttf-1-expression-a-potential-diagnostic-pitfall
#3
Michal Benej, Iva Zambo, Ondrej Bílek, Ivan Capov
Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517206/ck5-6-expression-based-on-morphological-components-in-adenoid-cystic-carcinoma-of-the-breast
#4
Haibo Wu
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517205/the-role-of-histology-grading-location-of-tumour-and-ploidy-in-evaluation-of-outcome-in-patients-with-liposarcoma
#5
Agnieszka Harazin-Lechowska, Bożena Ambroziak-Lackowska, Janusz Ryś, Anna Kruczak, Andrzej Gruchała, Agnieszka Jaszcz-Gruchała, Dominika Dańda, Marcin Przewoźnik, Krzysztof Halaszka
Department of Tumour Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Kraków, Poland The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517204/-human-papilloma-virus-infection-in-basal-cell-carcinoma-of-the-skin-a-systematic-review-and-meta-analysis-study
#6
Mazaher Ramezani, Masoud Sadeghi
Human papillomaviruses (HPVs) are a large and ubiquitous group of viruses that some of them have been suggested as a co-factor in the development of non-melanoma skin cancers. The aim of this meta-analysis study was to evaluate HPVs' prevalence in basal cell carcinoma (BCC) of the skin and the risk of them in the BCC patients compared with the healthy controls. Five databases were searched from January 1980 to February 2017. A random-effects meta-analysis was done with the event rate (ER) for the prevalence of HPVs and odds ratio (OR) for estimation of the incidence of HPVs...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517203/role-of-vascular-endothelial-growth-factor-in-inducing-production-of-angiopoetin-1-in-vivo-study-in-fisher-rats
#7
Piotr Barć, Tomasz Płonek, Dagmara Baczyńska, Artur Pupka, Wojciech Witkiewicz, Agnieszka Mastalerz-Migas, Artur Milnerowicz, Maciej Antkiewicz, Agnieszka Hałoń, Jan P Skóra
The aim of the study was to investigate how an intramuscular injection of plasmids with genes coding various pro-angiogenic factors: angiopoetin-1 (ANGPT1), vascular endothelial growth factor (VEGF165) and hepatic growth factor (HGF), influences the production of ANGPT1. 40 Healthy Fisher rats received i.m. injections containing plasmids encoding pro-angiogenic genes in thigh muscles. They were divided into four equal groups. The first group received the plANGPT1 plasmid and the second group- the pIRES/ANGPT1/VEGF165 bicistronic plasmid...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517202/is-the-inflammation-process-absolutely-absent-in-tendinopathy-of-the-long-head-of-the-biceps-tendon-histopathologic-study-of-the-long-head-of-the-biceps-tendon-after-arthroscopic-treatment
#8
Jan Zabrzyński, Łukasz Paczesny, Łukasz Łapaj, Dariusz Grzanka, Jacenty Szukalski
Tendinopathy of the long head of the biceps tendon is a difficult medical issue. Its pathogenesis and etiology is multifactorial and unclear. Tendinopathy is thought to be primarily degenerative in nature, as tendons are characterized by impaired regeneration and healing. Thirty-five patients with preoperatively diagnosed tendinopathy of long head of the biceps tendon were referred to the Orthopedics Department. All patients underwent an arthroscopic-assisted biceps tenodesis or tenotomy. The intra-articular portion of the long head of the biceps tendon was obtained from each of the patients who underwent arthroscopy...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517201/effects-of-transforming-growth-factor-%C3%AE-inhibitor-on-the-proliferation-of-glioma-stem-progenitor-cell
#9
Quanbin Zhang, Wei Guo, Chong Di, Meiqing Lou, Haimeng Li, Yaodong Zhao
Transforming growth factor-β (TGF-β) signaling pathways play an important role in inhibition and promotion of cell proliferation in neural stem cells (NSCs) and glioma stem/progenitor cells (GSPCs), respectively. However, the mechanisms underlying these processes remain unknown. We presumed that there may be functional inhibition at the receptor downstream of TGF-β signaling pathway leading to the activation of non- TGF-β/Smad signaling pathway, which stimulates the proliferation of GSPCs. In this study, GSPCs, from glioma cell lines SHG44, were cultivated with TGF-β receptor inhibitors (LY2157299 and LY2109761), and then the proliferative capability of GSPCs was measured; as well, the synthesis of TGF-β ligands, and the mRNA expression level of TGF-β and some key molecules of non-Smad signaling pathways were also detected...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517200/acquired-cystic-disease-associated-renal-cell-carcinoma-a-clinicopathological-study-of-seven-cases
#10
Naoto Kuroda, Takushi Naroda, Masato Tamura, Kenji Yorita, Fumiyoshi Kojima, Shin-Ichi Murata
The disease entity of acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) has been recently incorporated into the international renal tumor classification. However, there are a few descriptions on clinicopathologic features. We performed a clinicopathologic study of seven cases with ACD-RCC. All tumors were incidentally found. Histologically, the tumor consisted of microcystic or cribriform pattern of neoplastic cells with deeply eosinophilic to oncocytic cytoplasm in the stroma of oxalate crystal deposition...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517199/survivin-in-breast-lesions-immunohistochemical-analysis-of-196-cases
#11
Marian Adamkov, Slávka Drahošová, Jaroslava Chylíková, Desanka Výbohová
We examined the survivin expression pattern by immunohistochemistry in 43 fibroadenomas and 153 ductal carcinomas of the breast. The subcellular localization of survivin and the intensity of immunoreaction were assessed. We analyzed the differences of survivin expression between fibroadenomas and carcinomas. We also correlated the survivin expression pattern in carcinomas with other clinicomorphological parameters such as the age of patients, the grade and size of primary tumor as well as the lymph node metastasis...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517198/clinical-significance-of-nestin-and-its-association-with-survival-in-neuroendocrine-lung-tumours
#12
Barbara Brominska, Piotr Gabryel, Donata Jarmołowska-Jurczyszyn, Małgorzata Janicka-Jedyńska, Maciej Trojanowski, Nadia Sawicka-Gutaj, Rafał Czepczyński, Paweł Gut, Gabriel Bromiński, Wojciech Dyszkiewicz, Aldona Woźniak, Marek Ruchała
Nestin is considered to be a cancer stem cell marker. Nestin expression in neuroendocrine tumours might be useful to predict prognosis and facilitate treatment planning. 88 patients with neuroendocrine lung tumours operated in the Department of Thoracic Surgery from 2007 to 2015 were included into the study. Immunohistochemical staining for nestin was performed. Clinicopathological and survival data were retrospectively analyzed. Nestin expression was detected in 15 (17%) specimens. Multivariate analysis showed that lymph node metastases (p = 0...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517197/review-of-hereditary-leiomyomatosis-renal-cell-carcinoma-with-focus-on-clinical-and-pathobiological-aspects-of-renal-tumors
#13
Naoto Kuroda, Chisato Ohe, Ikuma Kato, Mitsuko Furuya, Masaya Baba, Yoji Nagashima, Yukio Nakatani, Ichiro Murakami, Ming Zhou, Michal Michal, Ondrej He, Mahul B Amin
The entity of hereditary leiomyomatosis renal cell carcinoma (HLRCC)-associated RCC has been proposed and integrated into the recent International Society of Urologic Pathology (ISUP) of renal tumors. This tumor is characterized by presence of cutaneous and/or uterine leiomyomas and RCC and autosomal dominant hereditary form. Grossly, HLRCC arising in the kidney show the solid tumor with frequent partial cystic area. Microscopically, the tumor typically shows papillary RCC, type 2, with eosinophilic large nucleoli reminiscent of cytomegaloviral inclusion and perinuclear clearing/haloes...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517196/professional-interest-in-dermatopathology-of-stanis%C3%A5-aw-ostrowski-the-only-one-state-polish-president-among-physicians
#14
Martyna Woltanowska, Andrzej Wincewicz, Piotr Woltanowski, Stanisław Sulkowski
President of prewar Lvov and Polish Republic on Exile, associate professor Stanisław Ostrowski was a dermatologist with a keen interest in dermatopathology. This study was based on original resources, which - mainly reports of his own authorship - were focused on dermatopathology. Stanisław Ostrowski provided excellent description of naevus epitheliomatosus sebaceus Wolters-Friboes both in Polish and German to be cited after decades in renowned handbooks of dermatopahtology published by Springer Verlag. His scientific output also includes meticulous presentation of Fox-Fordyce disease (apocrine miliaria) as well as gold-induced skin changes to Polish readership...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363922/-double-trouble-synchronous-mantle-cell-lymphoma-and-metastatic-squamous-cell-carcinoma-in-an-inguinal-lymph-node
#15
Anna Szumera-Ciećkiewicz, Barbara Bikowska-Opalach, Monika Prochorec-Sobieszek
Multiple primary neoplasms may also occur synchronously. Lymphoma may coexist with second malignant tumor in its primary location or malignant tumor may metastases to lymphomatous lymph nodes. Most often lymphoid component is a low grade lymphoma and coexistence of mantle cell lymphoma (MCL) and second malignant tumor is much rarer. In this report, we describe a case of synchronous squamous cell carcinoma and mantle cell lymphoma coexisting in an enlarged inguinal lymph node. To the best of our knowledge, this is the second report of synchronous metastatic squamous cell carcinoma and MCL in a lymph node...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363921/answer-to-the-teresa-pusiol-comments-to-the-paper-the-association-of-tumor-lymphocyte-infiltration-with-clinico-pathological-factor-and-survival-in-breast-cancer-by-huszno-et-al
#16
Joanna Huszno, Ewa Zembala-Nożyńska, Dariusz Lange, Zofia Kołosza, Elżbieta Nowara
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363920/comments-on-the-article-the-association-of-tumour-lymphocyte-infiltration-with-clinico-pathological-factors-and-survival-in-breast-cancer-by-huszno-et-al
#17
Teresa Pusiol
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363919/ewsr1-fusion-negative-smarcb1-deficient-primary-pulmonary-myxoid-sarcoma
#18
Abbas Agaimy, Thomas Duell, Alicia T Morresi-Hauf
Primary pulmonary myxoid sarcoma (PPMS) is a recently defined rare neoplasm with histological and molecular similarity to extraskeletal myxoid chondrosarcoma. To date, 20 cases have been reported. A 48-year-old man presented with a huge mass filling the right hemithorax and extending into the tracheobronchial system. Histological findings were consistent with PPMS. Immunohistochemistry was positive for vimentin, CD10, and EMA, but other lineage-specific markers were negative. SMARCB1 (INI1) expression was lost in the tumour cells...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363918/intratumoral-heterogeneity-for-inactivating-frameshift-mutation-of-cux1-and-sirt1-genes-in-gastric-and-colorectal-cancers
#19
Yun Sol Jo, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee
Both <I>CUX1</I> and <I>SIRT1</I> are considered tumor suppressor genes (TSGs), but it is not known whether <I>CUX1</I> and <I>SIRT1</I> alterations are different between high microsatellite instability (MSI-H) and microsatellite stable MSI (MSS) cancers. We identified frameshift mutations of <I>CUX1</I> in 4 cases of colorectal cancer (CRC) and of <I>SIRT1</I> in 1 case of gastric cancer (GC) and 3 cases of CRC. All of them were found in GC or CRC with MSI-H (3...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363917/research-directions-in-european-veterinary-pathology-in-2010-2016-based-on-the-congresses-of-the-european-society-of-veterinary-pathology-and-the-european-college-of-veterinary-pathologists
#20
Andrzej Dzikowski, Józef Szarek, Izabella Babińska, Mariusz Zbigniew Felsmann, Krystian Popławski, Dominika Gulda, Krzysztof Wąsowicz, Anna Wiśniewska
The objective of this paper is to depict the current research directions in veterinary pathology in Europe. The analysis was carried out based on the abstracts and agendas of the annual European Society of Veterinary Pathology (ESVP) congresses organised together with the European College of Veterinary Pathologists (ECVP) in 2010-2016. In total, 1444 presentations were evaluated, including 41 plenary lectures, 319 short oral presentations, and 1081 posters, and in 2016 also three science slams. It was found that infectious and parasitic diseases (467 presentations, 32...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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