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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://www.readbyqxmd.com/read/27543877/blue-nevus-presenting-as-an-endocervical-polyp
#1
S Masuko, Y Ikura, H Kato, Y Iwai
No abstract text is available yet for this article.
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543876/comments-on-the-article-ancient-cardiac-myxomas-another-point-of-view-in-the-light-of-tetraspanins
#2
I Haponiuk
No abstract text is available yet for this article.
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543875/shulman-disease-eosinophilic-fasciitis-in-x-linked-agammaglobulinemia
#3
A Pituch-Noworolska, H Mach-Tomalska, A Szaflarska, D Adamek
X-linked agammaglobulinemia (XLA) diagnosed in the first year of life is an immunodeficiency with a life-long indication for substitution of immunoglobulins, due to lack of B lymphocytes in the periphery. The decrease of bacterial infection frequency and severity is an effect of immunoglobulin replacement. However, in the majority of patients bronchiectasis and chronic sinusitis with an overgrown mucous membrane develop despite regular substitution. Autoimmune diseases as co-existing diseases in XLA are noted in a few patients presenting symptoms associated with arthritis, scleroderma and myositis...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543874/an-unusual-case-of-iga-dominant-postinfectious-glomerulonephritis-a-case-report-and-review-of-the-literature
#4
M Wagrowska-Danilewicz, M Danilewicz, I Fisiak, J Piskorska
We report a case of IgA-dominant postinfectious glomerulonephritis in a 49-year-old man presenting with acute kidney injury, nephrotic range proteinuria and hematuria. He suffered from ischemic heart disease, cardiac insufficiency, mitral regurgitation, tricuspid insufficiency, septal aneurysm and hypertension. Renal biopsy revealed segmental and focal endocapillary and mesangial hypercellularity, and thickening of the glomerular capillary wall. Immunofluorescence showed co-dominant strong coarse granular immunostaining of IgA, IgG and C3 mainly along the glomerular capillary wall...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543873/langerhans-cell-sarcoma-a-case-report-and-review-of-the-literature
#5
D T Liu, J Friesenbichler, L A Holzer, B Liegl-Atzwanger, C Beham-Schmid, A Leithner
We present the case of a 62-year-old male patient with a three-month history of pain in the left shoulder. Magnetic resonance imaging of the left scapula showed an osteo-destructive lesion. H and E stained sections revealed a Langerhans cell sarcoma, and immunohistochemistry was performed additionally; CD68, CD163, CD14, fascin, HLA-DR, lysozyme, S100 CD1a and langerin showed a positive reaction, while CD20, CD30, CD34, CD31, pan-cytokeratin, AE/1AE3, SMA, desmin, EMA, ERG, INI-1, CD21, CD4, PLAP, MPO and CD117c were negative...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543872/local-inflammatory-response-in-colorectal-cancer
#6
P Łaskowski, B Klim, K Ostrowski, M Szkudlarek, E Litwiejko-Pietryńczak, K Kitlas, S Nienartowicz, J Dzięcioł
Type and intensity of tumor-infiltrating lymphocytes (TILs) in close proximity to the primary tumor are prognostically significant in postoperative patients. High intensity of TILs is considered to be a prognostically beneficial factor. The research included 66 postoperative colorectal cancer patients. The control group comprised 20 colon segments. Monoclonal antibodies LCA, CD3, CD4, CD5, CD8, CD20, CD23 and CD138 were used to differentiate between T and B lymphocytes. Types of cells in the infiltrate were defined...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543871/%C3%AE-catenin-accumulation-and-s33f-mutation-of-ctnnb1-gene-in-colorectal-cancer-in-saudi-arabia
#7
S Y Alomar, L Mansour, A Abuderman, A Alkhuriji, M Arafah, S Alwasel, A H Harrath, M Almutairi, P Trayhyrn, J A Dar
Several risk factors associated with colorectal cancer (CRC) have been identified including β-catenin/CTNNB1 hotspot mutations. The levels of β-catenin within a cell are regulated via phosphorylation of the N terminus of β-catenin by GSK-3β. Thus far three serines (S33, 37, 45) and one threonine (T41) are considered to be the substrates for GSK-3β phosphorylation. In the present investigation an attempt was made to study the role of β-catenin mutations in exon-3 in 60 colorectal cancer patients from Kingdom of Saudi Arabia (KSA)...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543870/a-new-laboratory-device-with-mathematically-based-positioning-of-a-frozen-tissue-block-facilitating-precise-sectioning-of-large-specimens
#8
A Bieniek, Ł Matusiak, Z Woźniak, M Lichtenstein, J Szymkowski, M Kozioł, A Salwa, J C Szepietowski
Mohs micrographic surgery (MMS) is a treatment method aiming at thorough, personalized eradication of skin cancers by mean of staged excision of tissues surrounding the tumor with complete (100%) histopathological examination of their margins. In many MMS laboratories, the excised tissue is divided, shaped, frozen in a cryostat with a heat extractor and positioned manually (with the block on the object disc) in an articulated cryostat chuck during cutting. However, these activities may be difficult, time-consuming and associated with the risk of imprecise tissue sectioning...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543869/tumour-thrombus-consistency-has-no-impact-on-survival-in-patients-with-renal-cell-carcinoma
#9
T Gołąbek, M Przydacz, K Okoń, J Kopczyński, J Bukowczan, R Sobczyński, Ł Curyło, K Gołąbek, Ł Curyło, P Chłosta
The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus consistency (TTC) on overall survival remain controversial. The aim of this study was to investigate the prognostic role of TTC in patients' survival. We determined the tumour thrombus consistency (solid vs. friable) in a cohort of 84 patients with RCC and VTT who underwent nephrectomy with thrombectomy, and performed a retrospective evaluation of the patients' data from the prospectively maintained database...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543868/gli2-protein-expression-level-is-a-feasible-marker-of-ligand-dependent-hedgehog-activation-in-pancreatic-neoplasms
#10
Y Sugiyama, J Sasajima, Y Mizukami, K Koizumi, T Kawamoto, Y Ono, H Karasaki, H Tanabe, M Fujiya, Y Kohgo
The hedgehog pathway is known to promote proliferation of pancreatic ductal adenocarcinoma (PDA) and has been shown to restrain tumor progression. To understand how hedgehog causes these effects, we sought to carefully examine protein expression of hedgehog signaling components during different tumor stages. Genetically engineered mice, Pdx1-Cre;LSL-KrasG12D and Pdx1-Cre;LSL-KrasG12D;p53lox/+, were utilized to model distinct phases of tumorigenesis, pancreatic intraepithelial neoplasm (PanIN) and PDA. Human pancreatic specimens of intraductal papillary mucinous neoplasm (IPMN) and PDA were also employed...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543867/expression-pattern-of-isl-1-ttf-1-and-pax5-in-olfactory-neuroblastoma
#11
P Czapiewski, A Gorczyński, J Haybaeck, K Okoń, J Reszeć, W Skrzypczak, J Dzierżanowski, M Kunc, J Karczewska, W Biernat
Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543866/clinical-value-of-digital-image-analysis-in-the-diagnosis-of-urinary-bladder-cancer-particularly-in-aggressive-tumors-a-preliminary-report
#12
T Borkowski, A Monika Dulewicz, A Borkowski, D Piętka, P Radziszewski
The aim of the project was to evaluate the clinical value of a computer analysis of cytological specimen images obtained from urine and bladder washing samples. Three sample types (voided urine, catheterized urine and bladder washing) from 59 patients with primary or recurrent tumor were analyzed. All patients underwent cystoscopy and biopsy or resection. The histological results were compared with the results of the image analyzing computer system of collected urine samples. The consistency between the computer diagnosis and the clinical or histological diagnosis both in the presence and absence of cancer was as follows: 77% for voided urine samples, 72...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543865/morphological-assessment-of-thin-basement-membrane-disease
#13
J Zurawski, P Burchardt, J Moczko, M Seget, K Iwanik, J Sikora, A Woźniak, W Salwa-Zurawska
Thin basement membrane disease is more common than IgA nephropathy or Alport syndrome, which are also associated with the presence of erythrocyturia. Very few reports on the disorder are available in the Polish literature. The objective of this work was to analyze the results from 83 patients with thin basement membrane syndrome as well as to formulate a proposal of strict morphological assessment criteria for the disorder. Attention was drawn to the requirement of thickness of the lamina densa rather than the entire basement membrane thickness and a sufficiently high number of loops featuring thinned lamina densa, namely at least 80% of loops, being taken into account...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543864/comparison-of-skip-expression-in-malignant-pleural-mesotheliomas-with-ki-67-proliferation-index-and-prognostic-parameters
#14
G Türkcü, U AlabalIk, A N Keles, I Ibiloglu, M Küçüköner, H S Sen, H Büyükbayram
We aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic parameters. Pathological preparations of the patients diagnosed with MPM between 2006 and 2012 were evaluated. Immunohistochemical analyses were performed to evaluate the expression of SKIP and the Ki-67 proliferation index. Correlations between SKIP expression, clinicopathological factors and survival were investigated...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543863/professor-witold-nowicki-a-greatly-spirited-pathologist
#15
A Wincewicz, A Szepietowska, S Sulkowski
This paper presents a complete overview of the scientific, professional and social activity of a great Polish pathologist, Witold Nowicki (1878-1941), from mainly Polish-written, original sources with a major impact on mostly his own publications. The biographical commemoration of this eminent professor is not only due to the fact that he provided a profound microscopic characterization of pneumatosis cystoides in 1909 and 1924. Nowicki greatly influenced the development of anatomical pathology in Poland, having authored over 82 publications, with special reference to tuberculosis, lung cancer, sarcomatous carcinomas, scleroma and others...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27543862/review-of-renal-anastomosing-hemangioma-with-focus-on-clinical-and-pathological-aspects
#16
N Kuroda, C Ohe, S Deepika, K Yorita, S Mikami, M Furuya, Y Nagashima, O Hes, A Agaimy, M Michal, M B Amin
Renal anastomosing hemangiomas (RAH) has been recently proposed as a new entity. In this article, we summarize the clinicopathologic features of this tumor. RAH usually develops on a background of end-stage renal disease. Macroscopically, tumors are well-defined and their cut surface shows mahogany brown spongy tissue with epicenter in the renal medulla. Tumors are usually small, but larger lesions are reported. On microscopic examination, the tumor consists of sinusoid-like vascular channels lined by cuboidal endothelial cells with occasional hobnail-like appearance of endothelial cells closely mimicking splenic sinusoids...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27179280/histiocytic-necrotising-lymphadenitis-in-mediastinum-mimicking-thymoma-or-lymphoma-case-presentation-and-literature-review-of-kikuchi-fujimoto-disease
#17
REVIEW
P Błasiak, M Jeleń, A Rzechonek, M Marciniak, K Pawełczyk, J Cianciara, J Kołodziej, B Muszczyńska-Bernhard
Kikuchi Fujimoto disease (KFD) as a rare self-limiting lymphadenopathy of short and benign course concerns most frequently the lymph nodes of the neck. The most common symptoms are painfulness of the diseased area, fever and night sweating. The etiology is not well understood, but in the role of pathogenesis viral, autoimmune and genetic factors are taken into account. In the presented case of 37-year-old female it was necessary to exclude diseases such as lymphoma or thymoma because of atypical mediastinal location of Kikuchi Fujimoto disease...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27179279/giant-cribriform-adenocarcinoma-of-the-tongue-showing-prkd3-rearrangement
#18
H Majewska, A Skálová, I Weinreb, D Stodulski, M Hyrcza, C Stankiewicz, W Biernat
Cribriform adenocarcinoma of the tongue and minor salivary glands (CAMSG) was first described 16 years ago. It typically presents as a mass at the base of the tongue with early spread to lymph nodes, but without potential for distant metastases. In the 2005 World Health Organization Classification of Tumors the entity was classified as a possible variant of polymorphous low-grade adenocarcinoma (PLGA). Since then, more than 40 cases have been described in the English literature. Recently, PRKD1-3 translocation was found in more than 80% of CAMSGs...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27179278/identification-of-a-molecular-defect-in-a-stillborn-fetus-with-perinatal-lethal-hypophosphatasia-using-a-disease-associated-genome-sequencing-approach
#19
E M Olech, T Zemojtel, A Sowińska-Seidler, S Mundlos, P N Robinson, M Karczewski, A Jamsheer
Lethal skeletal disorders represent a heterogeneous and clinically variable group of genetic conditions, usually difficult to diagnose without post-mortem radiological assessment. Here we report on a stillborn patient delivered at 22 weeks of gestation who presented with severe skeletal symptoms comprising limb shortening and intrauterine fractures detected upon prenatal ultrasound and autopsy examination. Since post-mortem X-ray was refused and no phenotypic diagnosis could be attempted, we performed next-generation sequencing (NGS) of 2741 genes associated with all known Mendelian disorders...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27179277/ancient-cardiac-myxomas-another-point-of-view-in-the-light-of-tetraspanins
#20
P Lewitowicz, P Bernaczyk, A Horecka-Lewitowicz, U Leszczyńska, J Reszeć, T Hirnle, A Wincewicz
Myxomas are the most common non-invasive but life-threatening cardiac neoplasms due to obstruction of heart chambers and risk of embolism in a manner resembling thromboembolism as well. They can occasionally disseminate via their detached fragments into the bloodstream to seed and grow as secondary still benign tumors. In this study we evaluated morphological and clinical aspects of 14 ancient, degenerated left or right-sided cardiac atrial myxomas with expression of CD9 and CD63, which are found to contribute to platelet activation, aggregation and, as a result, intratumoral thrombosis or fragmentation...
March 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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