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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://www.readbyqxmd.com/read/29895134/lymphoepithelioma-like-breast-carcinoma
#1
REVIEW
Nektarios Koufopoulos, John Syrios, Asimina Papanikolaou, Ioannis Misitzis, Kasiani A Kapatou, Dionysis Dimas, Lubna Khaldi
Nasopharyngeal lymphoepithelioma is an undifferentiated carcinoma in a dominated lymphoplasma-histiocyte stroma. Lymphoepithelioma-like carcinoma of the breast is the mammary counterpart of the lymphoepithelioma of the nasopharynx and is characterised by proliferation of poorly differentiated malignant cells within a prominent lymphoid infiltrate. It is a very rare primary carcinoma of the breast first reported in 1994 by Kumar and Kumar. Fewer than 40 cases have been reported in the English literature. In this manuscript a case of lymphoepithelioma-like carcinoma of the breast in a 57-year-old patient is reported along with a literature review on this rare entity...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895133/keloidal-like-local-recurrence-after-infiltrating-adenosquamous-breast-carcinoma-with-stromal-overgrowth-mimicking-a-benign-skin-lesion
#2
Simona Stolnicu, Alexandra Giurgi, Adrian Naznean, Cristian Podoleanu, Anca Chiriac
We present a very rare case of an adenosquamous infiltrating breast carcinoma with sarcomatous stromal overgrowth of hypocellular collagenised type, which subsequently developed local recurrence, mistaken for a benign skin lesion due to bland keloid-like morphological appearance. All the histological, immunohistochemical, and clinical features must be taken into consideration when distinguishing between a benign skin lesion and a local recurrence of a rare subtype of breast carcinoma.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895132/lymphoepithelioma-like-carcinoma-of-the-endometrium-case-report-of-a-rare-tumour-with-comprehensive-immunohistochemical-and-molecular-analysis
#3
Kristýna Němejcová, Nikola Hájková, Ivana Tichá, Michaela Bártů, Dagmar Dolínská, Vladimír Kalist, Pavel Dundr
We are reporting a case of endometrial lymphoepithelioma-like carcinoma (LELC) in a 63-year-old female. Microscopically, the tumor consisted of groups of tumor cells surrounded by dense lymphoplasmacytic infiltrate. Immunohistochemically, the tumour cells were positive for cytokeratins AE1/AE3, EMA, PAX8, p16, and estrogen receptors. Protein p53 showed an aberrant type of expression. Molecular genetic analysis revealed mutations in the TP53 and PIKP53CA genes. Based on our results, we believe that the tumor represents an unusual morphological variant of endometrial serous carcinoma...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895131/incidental-low-fat-variant-of-spindle-cell-lipoma-a-novel-tumour-of-the-small-intestine
#4
J Fernando Val-Bernal, Sandra Hermana, José-Javier Gómez-Román
A woman underwent surgical intervention for a carcinoma of the ovary. In the intervention, a submucosal nodule of the ileum was found. Pathological study revealed a spindle cell lipoma (SCL). This case revealed the presence of CD34-positive spindle and stellate cells with dendritic cytoplasmic prolongations, a feature shared with dendritic fibromyxolipoma. Fluorescence in <i><i><i>in situ</i></i></i> hybridisation analysis showed 13q14 heterozygous deletion. Spindle cell lipoma of the small intestine has not been previously reported...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895130/single-nucleotide-polymorphisms-of-xrcc3-gene-in-hepatocellular-carcinoma-relationship-with-clinicopathological-features
#5
Elena-Roxana Avadanei, Simona-Eliza Giusca, Lucian Negura, Irina-Draga Caruntu
Recent studies support the involvement of XRCC3 gene polymorphisms in carcinogenesis. Our study focuses on the identification of polymorphic variants of XRCC3 in hepatocellular carcinoma (HCC) and an analysis of the relationship between these polymorphic variants and clinicopathological (including the genotype specific risk) and survival characteristics. Fifty cases of HCC were genotyped using molecular biology techniques for Thr241Met, rs861539 (c.722C>T) and 5'-UTR, rs1799796 (c.562-14A>G) polymorphisms...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895129/overexpression-of-adam10-in-oral-squamous-cell-carcinoma-with-metastases
#6
COMPARATIVE STUDY
Olga Stasikowska-Kanicka, Małgorzata Wągrowska-Danilewicz, Paulina Kulicka, Marian Danilewicz
ADAMs (a disintegrin and metalloproteinase) are important mediators of cell signalling events, which play a role in the pathogenesis and progression of cancers. Immunohistochemical method was used to examine the immunoexpression of ADAM10 and microvessel density in 80 cases of oral squamous cell carcinoma (OSCC): without metastases - OSCC M(-) (n = 38), and with metastases - OSCC M(+) (n = 42), in 24 cases of oral leukoplakia (OLK), (15 cases with low-grade dysplasia - OLK-LG, and 9 cases with high-grade dysplasia - OLK-HG), and 19 controls...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895128/the-influence-of-fibronectin-on-proliferation-and-apoptosis-of-acute-lymphoblastic-leukaemia-cells-in-vitro
#7
COMPARATIVE STUDY
Joanna Włodek, Anna Pituch-Noworolska
The extracellular matrix (ECM) is a dynamic environment involved in the regulation of haematopoiesis. A crucial role of this structure is the promotion of proliferation, maturation, and differentiation of haematopoietic stem cells (HSC), and adhesion and migration of HSC in bone marrow. In the present study the effect of ECM proteins (fibronectin, collagens, laminin, thrombospondin, and vitronectin) on proliferation and apoptosis of acute lymphoblastic leukaemia cells isolated from acute lymphoblastic leukaemia (ALL) patients (<i><i><i><i><i>in vitro</i></i></i></i></i>) was assessed...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895127/angioinvasion-as-a-factor-for-predicting-aggressive-outcome-in-primary-thyroid-angiosarcoma-three-case-reports-and-literature-review
#8
REVIEW
Adela Nechifor-Boilă, Myriam Decaussin-Petrucci, Agota Varga-Ilyés, Laura Chinezu, Cosmin Caraşca, Angela Borda
We report three primary thyroid angiosarcoma (PTA) cases revealing distinctive morphological features. A systematic literature review completed our analysis to evaluate the most important morphological factors for predicting prognosis in PTAs. Three rare PTA cases were analysed. In addition, we identified 46 previously reported PTAs with available follow-up data to compare morphological features related to prognosis between patients with a favourable <i><i><i><i>versus</i></i></i></i> aggressive outcome...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895126/expression-of-growth-hormone-releasing-hormone-receptors-in-apocrine-adnexal-tumours-and-apocrine-glands-of-the-skin
#9
COMPARATIVE STUDY
Bence Kővári, Lajos Kocsis, Erika Varga, Gábor Cserni
Encouraged by our previous finding of growth hormone-releasing hormone receptor (GHRH-R) expression in metaplastic and neoplastic apocrine breast epithelium, we examined a small series of skin adnexal tumours with various degrees of apocrine (oxyphilic) differentiation, as well as normal axillary and anogenital apocrine sweat glands, for the expression of GHRH-R. Sections of formalin-fixed paraffin-embedded tissue blocks were immunostained for gross cystic disease fluid protein-15 (GCDFP-15) and androgen receptor (AR), to prove apocrine differentiation and correlate it with areas of GHRH-R expression...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895125/clinical-efficacy-of-p16-ki-67-dual-stained-cervical-cytology-in-secondary-prevention-of-cervical-cancer
#10
Aleksander Celewicz, Marta Celewicz, Małgorzata Wężowska, Anita Chudecka-Głaz, Janusz Menkiszak, Elzbieta Urasińska
Cervical cancer is the third most common malignant neoplasm in women worldwide. HPV infection is the necessary factor for the cancer to develop. HPV DNA can be integrated into the genome of squamous epithelium and cause transcription of the viral oncoproteins and development of invasive cancer within 15-20 years. We assessed ICC co-expression of p16/Ki-67 proteins in smears collected from the uterine cervix and the association between p16/Ki-67 co-expression and cytologic and histologic results. Samples were collected from 93 women using liquid based cytology (LBC)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895124/smac-protein-expression-as-a-potent-favorable-prognostic-factor-in-locally-advanced-breast-cancer
#11
Piotr Pluta, Dorota Jesionek-Kupnicka, Joanna Kubicka-Wołkowska, Agnieszka Pluta, Kamil Brzozowski, Piotr Potemski, Janusz Piekarski, Radzisław Kordek, Arkadiusz Jeziorski
Preoperative systemic therapy including neoadjuvant chemotherapy (NCT) is standard treatment in locally advanced breast cancer (LABC), the aim of which is to enable a radical surgery and to reduce the risk of local and distant recurrence. It has been established that NCT in LABC may effectively induce apoptosis. The study objective was to assess the role of a proapoptotic second mitochondria-derived activator of apoptosis (SMAC) in LABC. The study group comprised 56 patients with advanced non-metastatic breast cancer (stage IIB -node positive and III), who received NCT followed by surgery and adjuvant treatment...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895123/rhabdomyosarcoma-in-children-current-pathologic-and-molecular-classification
#12
REVIEW
Ireneusz Dziuba, Paweł Kurzawa, Michał Dopierała, Ana B Larque, Danuta Januszkiewicz-Lewandowska
The last 25 years have brought significant progress in the treatment of sarcomas in children, especially rhabdomyosarcoma (RMS). Nevertheless, treatment failure in some patients results from considerable biological heterogeneity noted in these tumours. RMS, the most common malignant soft tissue neoplasm in children, includes two main subtypes: embryonal (ERMS) and alveolar (ARMS). Due to greater aggressiveness and worse prognosis of ARMS in comparison to ERMS, discrimination between different rhabdomyosarcoma subtypes is of crucial clinical importance...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895122/comprehensive-histopathological-diagnostics-of-aggressive-b-cell-lymphomas-based-on-the-updated-criteria-of-the-world-health-organisation-s-2017-classification
#13
REVIEW
Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Beata Grygalewicz, Dorota Jesionek-Kupnicka, Andrzej Gruchała, Bogna Ziarkiewicz-Wróblewska, Krystyna Gałązka, Joanna Reszeć, Katarzyna Borg, Monika Prochorec-Sobieszek
Revision of the fourth edition of the World Health Organisation (WHO) Classification of Haematopoietic and Lymphatic Tissues, which was published in 2017, introduced important changes updating the biology, pathology, genetics, and clinical presentation of aggressive B-cell lymphomas. High grade B-cell lymphomas (HGBLs) replaced B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, the new provisional entity Burkitt-like lymphoma with 11q aberration was identified, and some categories were upgraded, e...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517209/medulloblastoma-with-extensive-nodularity-shh-medulloblastoma
#14
Iga Alicja Fudyma, Nitin R Wadhwani
Medulloblastoma is the most common CNS embryonal tumor and the most common malignant tumor of childhood. Its overall incidence is 1.8 cases per 1 million people, with a childhood incidence of 6 cases per 1 million. 77 percent of patients are less than 19 years old. Medulloblastoma occurs in the 4th ventricle and usually presents with symptoms of increased intracranial pressure (headaches, nausea, vomiting) and signs of obstructive hydrocephalus. Medulloblastoma is both histologically and genetically defined with prognosis that depends on classification...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517208/asymptomatic-uterus-like-mass-ulm-of-the-extraperitoneal-space-a-case-report-of-a-rare-finding-with-unusual-clinical-presentation-and-review-of-the-literature
#15
REVIEW
Konrad Muzykiewicz, Paweł Majchrzak, Ewa Iwańska, Wiktor Szatkowski, Piotr Szubel, Kazimierz Karolewski
The paper presents a case of a uterus-like mass (ULM), a rare type of tumour of the female reproductive system, which did not present any clinical symptoms described in other cases of ULMs. There are 35 reported cases of this type of tumour. It is defined as a lesion composed of smooth muscle-like stromal cells with a central cavity lined with endometrial type epithelium. There are three theories on the pathogenesis of ULMs which we discuss along with clinical presentation, diagnostic features, treatment options and potential oncological implications of this type of tumour, based on our case, and the review of the literature...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517207/soft-tissue-metastasis-of-mediastinal-non-functioning-paraganglioma-with-unusual-ttf-1-expression-a-potential-diagnostic-pitfall
#16
Michal Benej, Iva Zambo, Ondrej Bílek, Ivan Capov
Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517206/ck5-6-expression-based-on-morphological-components-in-adenoid-cystic-carcinoma-of-the-breast
#17
Haibo Wu
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517205/the-role-of-histology-grading-location-of-tumour-and-ploidy-in-evaluation-of-outcome-in-patients-with-liposarcoma
#18
Agnieszka Harazin-Lechowska, Bożena Ambroziak-Lackowska, Janusz Ryś, Anna Kruczak, Andrzej Gruchała, Agnieszka Jaszcz-Gruchała, Dominika Dańda, Marcin Przewoźnik, Krzysztof Halaszka
Department of Tumour Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Kraków, Poland The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517204/-human-papilloma-virus-infection-in-basal-cell-carcinoma-of-the-skin-a-systematic-review-and-meta-analysis-study
#19
REVIEW
Mazaher Ramezani, Masoud Sadeghi
Human papillomaviruses (HPVs) are a large and ubiquitous group of viruses that some of them have been suggested as a co-factor in the development of non-melanoma skin cancers. The aim of this meta-analysis study was to evaluate HPVs' prevalence in basal cell carcinoma (BCC) of the skin and the risk of them in the BCC patients compared with the healthy controls. Five databases were searched from January 1980 to February 2017. A random-effects meta-analysis was done with the event rate (ER) for the prevalence of HPVs and odds ratio (OR) for estimation of the incidence of HPVs...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29517203/role-of-vascular-endothelial-growth-factor-in-inducing-production-of-angiopoetin-1-in-vivo-study-in-fisher-rats
#20
Piotr Barć, Tomasz Płonek, Dagmara Baczyńska, Artur Pupka, Wojciech Witkiewicz, Agnieszka Mastalerz-Migas, Artur Milnerowicz, Maciej Antkiewicz, Agnieszka Hałoń, Jan P Skóra
The aim of the study was to investigate how an intramuscular injection of plasmids with genes coding various pro-angiogenic factors: angiopoetin-1 (ANGPT1), vascular endothelial growth factor (VEGF165) and hepatic growth factor (HGF), influences the production of ANGPT1. 40 Healthy Fisher rats received i.m. injections containing plasmids encoding pro-angiogenic genes in thigh muscles. They were divided into four equal groups. The first group received the plANGPT1 plasmid and the second group- the pIRES/ANGPT1/VEGF165 bicistronic plasmid...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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