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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://www.readbyqxmd.com/read/29363922/-double-trouble-synchronous-mantle-cell-lymphoma-and-metastatic-squamous-cell-carcinoma-in-an-inguinal-lymph-node
#1
Anna Szumera-Ciećkiewicz, Barbara Bikowska-Opalach, Monika Prochorec-Sobieszek
Multiple primary neoplasms may also occur synchronously. Lymphoma may coexist with second malignant tumor in its primary location or malignant tumor may metastases to lymphomatous lymph nodes. Most often lymphoid component is a low grade lymphoma and coexistence of mantle cell lymphoma (MCL) and second malignant tumor is much rarer. In this report, we describe a case of synchronous squamous cell carcinoma and mantle cell lymphoma coexisting in an enlarged inguinal lymph node. To the best of our knowledge, this is the second report of synchronous metastatic squamous cell carcinoma and MCL in a lymph node...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363921/answer-to-the-teresa-pusiol-comments-to-the-paper-the-association-of-tumor-lymphocyte-infiltration-with-clinico-pathological-factor-and-survival-in-breast-cancer-by-huszno-et-al
#2
Joanna Huszno, Ewa Zembala-Nożyńska, Dariusz Lange, Zofia Kołosza, Elżbieta Nowara
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363920/comments-on-the-article-the-association-of-tumour-lymphocyte-infiltration-with-clinico-pathological-factors-and-survival-in-breast-cancer-by-huszno-et-al
#3
Teresa Pusiol
No abstract text is available yet for this article.
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363919/ewsr1-fusion-negative-smarcb1-deficient-primary-pulmonary-myxoid-sarcoma
#4
Abbas Agaimy, Thomas Duell, Alicia T Morresi-Hauf
Primary pulmonary myxoid sarcoma (PPMS) is a recently defined rare neoplasm with histological and molecular similarity to extraskeletal myxoid chondrosarcoma. To date, 20 cases have been reported. A 48-year-old man presented with a huge mass filling the right hemithorax and extending into the tracheobronchial system. Histological findings were consistent with PPMS. Immunohistochemistry was positive for vimentin, CD10, and EMA, but other lineage-specific markers were negative. SMARCB1 (INI1) expression was lost in the tumour cells...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363918/intratumoral-heterogeneity-for-inactivating-frameshift-mutation-of-cux1-and-sirt1-genes-in-gastric-and-colorectal-cancers
#5
Yun Sol Jo, Min Sung Kim, Nam Jin Yoo, Sug Hyung Lee
Both <I>CUX1</I> and <I>SIRT1</I> are considered tumor suppressor genes (TSGs), but it is not known whether <I>CUX1</I> and <I>SIRT1</I> alterations are different between high microsatellite instability (MSI-H) and microsatellite stable MSI (MSS) cancers. We identified frameshift mutations of <I>CUX1</I> in 4 cases of colorectal cancer (CRC) and of <I>SIRT1</I> in 1 case of gastric cancer (GC) and 3 cases of CRC. All of them were found in GC or CRC with MSI-H (3...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363917/research-directions-in-european-veterinary-pathology-in-2010-2016-based-on-the-congresses-of-the-european-society-of-veterinary-pathology-and-the-european-college-of-veterinary-pathologists
#6
Andrzej Dzikowski, Józef Szarek, Izabella Babińska, Mariusz Zbigniew Felsmann, Krystian Popławski, Dominika Gulda, Krzysztof Wąsowicz, Anna Wiśniewska
The objective of this paper is to depict the current research directions in veterinary pathology in Europe. The analysis was carried out based on the abstracts and agendas of the annual European Society of Veterinary Pathology (ESVP) congresses organised together with the European College of Veterinary Pathologists (ECVP) in 2010-2016. In total, 1444 presentations were evaluated, including 41 plenary lectures, 319 short oral presentations, and 1081 posters, and in 2016 also three science slams. It was found that infectious and parasitic diseases (467 presentations, 32...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363916/the-significance-of-angiogenesis-for-predicting-optimal-therapeutic-response-in-chronic-myeloid-leukaemia-patients
#7
Irena Ćojbašić, Lana Mačukanović-Golubović, Dragan Mihailović, Miodrag Vučić, Žarko Ćojbašić
In this study the correlation and the prognostic value of the morphometric parameters of angiogenesis for optimal therapeutic response to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukaemia (CML), i.e. complete cytogenetic response (CCgR) and major molecular response (MMoR), were investigated. Microvascular density (MVD) and a number of different size- and shape-related morphometric parameters of microvessels of bone marrow biopsy from 40 CML patients and 20 controls were examined...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363915/impact-of-tgf-%C3%AE-1-expression-and-509c-t-polymorphism-in-the-tgf-%C3%AE-1-gene-on-the-progression-and-survival-of-gastric-cancer
#8
Julian Ananiev, Irena Manolova, Elina Aleksandrova, Maya Gulubova
The aim of this study was to examine the expression of TGF-β1 and TGF-β receptor type II (RII) and the impact of the -509C>T single nucleotide polymorphism (SNP) in the gene in relation to clinicopathological factors in gastric cancer (GC). Using immunohistochemistry we investigated 43 patients with GC for expression of TGF-β1 and TGF-β-RII. Consequently, RFLP-PCR was performed to analyze the presence of -509C>T polymorphism in the TGF-β1 gene. We found that 72.1% of GCs had cytoplasmic TGF-β1 expression and 27...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363914/expression-of-resistin-in-the-liver-of-patients-with-non-alcoholic-fatty-liver-disease
#9
Piotr Gierej, Beata Gierej, Piotr Kalinowski, Tadeusz Wróblewski, Rafał Paluszkiewicz, Konrad Kobryń, Bogna Ziarkiewicz-Wróblewska
Adipokines are cytokines that presumably connect the pathologies of metabolic syndrome. One of the adipokines is resistin, the role of which in insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD) needs to be determined. Liver biopsy specimens were obtained intraoperatively from 214 obese patients. Histological assessment was based on NAFLD activity score according to Kleiner. Statistical analysis involved semi-quantitive immunohistochemistry assessment of resistin staining and: NAFLD status in obese patients compared with a non-obese control group, selected clinical data (age, sex, body mass index - BMI), selected biochemical data, comorbidities (hypertension, type 2 diabetes mellitus, dyslipidaemia), and metformin treatment in patients with type 2 diabetes mellitus...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363913/-immunohistochemical-differentiation-between-muscularis-mucosae-and-muscularis-propria-for-improving-the-staging-of-bladder-cancer-in-patients-undergoing-transurethral-resection-of-bladder-tumours
#10
Sławomir Poletajew, Ewa Wolińska, Aleksander Wasiutyński, Bartosz Dybowski, Piotr Radziszewski, Barbara Górnicka
Microscopic differentiation between muscularis mucosae (MM) and muscularis propria (MP) of the bladder in the material obtained during transurethral resection (TUR) remains difficult. The study was aimed at determination of the usefulness of immunohistochemical staining in this context. Forty-seven TUR specimens were stained with 5 mouse anti-human antibodies: anti-desmin, anti-filamin, anti-type IV collagen, anti-smoothelin, and anti-vimentin. Slides were assessed under light microscopy and the intensity of the immune reaction within MM and MP was evaluated on a four-level visual scale as follows: negative (0) and weakly (1), moderately (2), or strongly (3) positive...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363912/massively-parallel-targeted-resequencing-reveals-novel-genetic-variants-associated-with-aspergillosis-in-paediatric-patients-with-haematological-malignancies
#11
Katarzyna Skonieczna, Jan Styczyński, Anna Krenska, Piotr Stawiński, Rafał Płoski, Katarzyna Derwich, Wanda Badowska, Mariusz Wysocki, Tomasz Grzybowski
This study aimed to find novel genetic variants of susceptibility to aspąergillosis in paediatric patients with haematological malignancies. Complete sequences of fifteen genes of human innate immunity (CCL2, CCR2, CD209, CLEC6A, CLEC7A and ten TLR genes) were studied in 40 patients diagnosed with haematological disorders (20 unaffected and 20 affected by aspergillosis). All samples were sequenced with MiSeq (Illumina) and 454 (Roche Diagnostics) technologies. Statistical significance of the differences between studied groups was determined using the two-tailed Fisher's exact test...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363911/comparison-of-clinicopathological-features-in-incidental-and-nonincidental-papillary-thyroid-carcinomas-in-308-patients
#12
Nuray Can, Filiz Ozyilmaz, Mehmet Celik, Atakan Y Sezer, Necdet Sut, Ebru Tastekin, Semra Ayturk, Funda Ustun, Buket Y Bulbul, Sibel Guldiken
Incidental papillary thyroid carcinomas (IPTCs) consist of a significant portion of increasing incidence in papillary thyroid carcinomas. This study investigated the clinicopathological features of IPTCs from different perspectives and by comparing nonincidental PTCs (NIPTCs) in patients who underwent total thyroidectomy and lymph node dissection. Basic results were as follows. IPTC was present in 27.9% of 308 patients. IPTCs were significantly accompanied by lymphocytic thyroiditis (LT), particularly, multinodular hyperplasia (MNH)...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29363910/mast-cells-as-the-strength-of-the-inflammatory-process
#13
Joanna Pastwińska, Justyna Agier, Jarosław Dastych, Ewa Brzezińska-Błaszczyk
The inflammatory process is a complex host defence mechanism aimed at the elimination of deleterious factors disturbing homeostasis. Inflammation consists of several interdependent stages controlled by a wide range of mediators. Those include acute phase proteins, heat shock proteins, complement components, biogenic amines, cytokines, lipid-derived mediators, reactive oxygen species, nitric oxide, proteolytic enzymes, and kinins. Due to the strategic location in the body, mast cells play a protective role in the inflammatory process, through its initiation, amplification, and resolution...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025254/chromoblastomycosis-of-the-leg
#14
Akash Pramod Sali, Ayushi Sahay
We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Histopathological examination of the skin biopsy revealed the presence of characteristic pigmented sclerotic bodies with pseudoepitheliomatous hyperplasia of the overlying epithelium...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025253/pathology-of-mitochondria-in-melas-syndrome-an-ultrastructural-study
#15
Paulina Felczak, Eliza Lewandowska, Iwona Stępniak, Monika Ołdak, Agnieszka Pollak, Urszula Lechowicz, Elżbieta Pasennik, Tomasz Stępień, Teresa Wierzba-Bobrowicz
Ultrastructural changes in skeletal muscle biopsy in a 24-year-old female patient with clinically suspected mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes (MELAS) syndrome are presented. We observed proliferation and/or pleomorphism of mitochondria in skeletal muscle and smooth muscle cells of arterioles, as well as in pericytes of capillaries. Paracrystalline inclusions were found only in damaged mitochondria of skeletal muscle. Genetic testing revealed a point mutation in A3243G tRNALeu(UUR) typical for MELAS syndrome...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025252/solitary-breast-metastasis-from-oestrogen-receptor-positive-pulmonary-adenocarcinoma-report-of-a-case-with-a-potential-pitfall
#16
Gábor Cserni
Solitary breast metastases are rare and mimic primary breast carcinoma. A 60-year-old female with a history of pulmonary adenocarcinoma presented with a solitary left breast lump suspicious for malignancy on breast imaging. Core-needle biopsy disclosed an adenocarcinoma strongly and diffusely positive for oestrogen receptors. Further immunohistochemistry was consistent with the breast tumour being a solitary metastasis of her pulmonary cancer. Clinicians and pathologists should be aware of the fact that pulmonary adenocarcinomas may sometimes display strong rather than only focal positivity for oestrogen receptors by immunohistochemistry and may mimic breast cancer of no special type...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025251/glial-choristoma-of-the-tongue-clinicopathological-analysis-of-a-case-and-pathogenetic-insights
#17
Alessandro Corsi, Norman Veccia, Mara Riminucci
Glial choristoma of the tongue is a rare developmental anomaly usually occurring in the first two years of life. Although diverse theories have been suggested to explain its development, they do not seem to take into account the normal tongue development. We report here on a glial choristoma of the tongue in a two-month-old male with the aim to describe the clinicopathological features of this lesion and to discuss the pathogenetic role of the cells that normally migrate from the cranial neural crests to generate the ectomesenchymal derivatives of the tongue and express neuroglial differentiation as normal developmental pathway...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025250/ceramic-polylactide-composite-material-used-in-a-model-of-healing-of-osseous-defects-in-rabbits
#18
Paweł Myciński, Joanna Zarzecka, Agnieszka Skórska-Stania, Agnieszka Jelonek, Krzysztof Okoń, Maria Wróbel
The growing demand for various kinds of bone regeneration material has in turn increased the desire to find materials with optimal physical, chemical, and biological properties. The objective of the present study was to identify the proportions of ceramic and polylactide components in a bone substitute material prepared in collaboration with the Crystal Chemistry of Drugs Team of the Faculty of Chemistry at the Jagiellonian University, which would be optimal for bone regeneration processes. Another goal was to provide a histological analysis of the influence of a ceramic-polylactide composite on the healing of osseous defects in rabbits...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025249/the-utility-of-glomerular-c4d-immunostaining-in-renal-biopsies-in-patients-with-immunoglobulin-a-nephropathy-a-clinicopathological-study
#19
Małgorzata Wągrowska-Danilewicz, Marian Danilewicz
The course of IgA nephropathy (IgAN) is highly variable and ranges from a totally benign condition to end-stage renal disease in approximately one third of cases. The identification of new prognostic markers could provide insights into the pathogenesis of IgAN and unveil new therapeutic avenues. Glomerular deposition of C4d is a marker of activation of the lectin pathway of complement. It is thought that activation of the lectin pathway in IgAN is associated with more severe renal damage, and more severe histological findings...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025248/ultrastructural-liver-changes-in-the-experimental-thyrotoxicosis
#20
Nadiya Vasylivna Pasyechko, Iryna Ihorivna Kuleshko, Veronika Mykolaiivna Kulchinska, Liudmyla Valeriivna Naumova, Iryna Volodymyrivna Smachylo, Anzhela Olehivna Bob, Liudmyla Volodymyrivna Radetska, Mykhailo Yevhenovych Havryliuk, Olha Mykolaiivna Sopel, Liudmyla Petrivna Mazur
Aim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis. For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that received intragastric sodium chloride 0.9% solution, the second group (12 animals) - animals with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 2 weeks, and the third group (12 animals) - rats with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 4 weeks...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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