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Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists

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https://www.readbyqxmd.com/read/30351870/quiz-what-is-your-diagnosis
#1
Yui Hattori, Kazuhiro Sentani, Naoki Matsuoka, Hirofumi Nakayama, Takuya Hattori, Yoshiki Kudo, Wataru Yasui
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351869/intraoral-manifestation-of-systemic-al-amyloidosis-with-unique-microscopic-presentation-of-intracellular-amyloid-deposition-in-striated-muscles
#2
Zuzanna Oruba, Tomasz Kaczmarzyk, Katarzyna Urbańczyk, Artur Jurczyszyn, Szymon Fornagiel, Krystyna Gałązka, Anna Bednarczyk, Maria Chomyszyn-Gajewska
We report the history of a 59-year old patient with systemic AL amyloidosis of intraoral manifestation. The patient first presented with complaints about dysphagia and remarkable enlargement of the tongue with highly reduced mobility, as well as bilateral submucosal thickenings on the cheeks. Histopathological examination of the incisional biopsy of the buccal mucosa and underlying tissues revealed AL amyloidosis. The microscopic presentation was, however, unique, as the amyloid deposits were present intracellularly in the striated muscles...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351868/dedifferentiated-endometrial-carcinoma-an-ongoing-diagnostic-dilemma
#3
Ameer Hamza, Sidrah Khawar, Warda Ibrar, Ramen Sakhi, Lamia Fathallah
Tumours of uterine corpus are the most common gynaecological malignancies. The clinicopathological features of most of these tumours are well understood; however, dedifferentiated endometrial carcinoma still requires a lot of research to establish adequate management guidelines. The entity was first described in 2006 and is an aggressive tumour with poor prognosis. We present two cases of this tumour with a literature review, emphasising morphologic and immunohistochemical features that may help in the differential diagnosis...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351867/fibroma-of-the-breast-a-rare-tumour-in-the-spectrum-of-the-benign-spindle-cell-tumours-of-the-mammary-stroma
#4
Magro Gaetano, Angelico Giuseppe, Spadola Saveria, Ragusa Rosalia, Righi Alberto, Orvieto Enrico
Benign spindle cell tumours of the mammary stroma comprises different lesions that show a variable degree of fibroblastic/myofibroblastic differentiation. We herein report a previously under-recognised hypocellular fibrocollagenous tumour of the breast, for which the term "fibroma" is proposed. The tumour was composed of CD34-positive bland-looking spindle cells embedded in an abundant hyalinised stroma. Fluorescence in situ hybridisation (FISH) showed 13q14 deletion in most neoplastic cells, a chromosomal alteration typically found in mammary myofibroblastoma...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351866/encapsulated-papillary-breast-carcinoma-in-a-male-patient-in-association-with-microdeposits-of-carcinoma-cells-in-the-needle-track-and-sentinel-lymph-node-treated-conservatively
#5
Simona Stolnicu, Alexandra Giurgi, Orsolya Bauer, Anca Chiriac, Cristian Podoleanu, Rares Georgescu
We present an encapsulated papillary breast carcinoma in a male patient, in association with microdeposits of carcinoma cells within the needle track, in the lymphatic spaces of the breast parenchyma and subcapsular sinus of two sentinel lymph nodes in which conservative treatment has been recommended. Both in females and males, papillary tumours and particularly encapsulated papillary breast carcinoma can be associated with microdeposits mechanically displaced, which have to be differentiated from true invasion and metastases and treated conservatively...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351865/professor-andrew-obrzut-the-first-head-of-the-pathological-anatomy-department-1896-1910-of-the-medical-faculty-of-jan-casimir-university-in-lviv
#6
Dmytro Zerbino, Liliya I Volos
No abstract text is available yet for this article.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351864/lymphoid-environment-in-molecular-subtypes-of-breast-cancer
#7
Anna Glajcar, Joanna Szpor, Katarzyna Ewa Tyrak, Joanna Streb, Diana Hodorowicz-Zaniewska, Krzysztof Okoń
Recently, a large body of evidence has shown that the microenvironment of invasive breast carcinoma affects its development and the patient's outcome, and vice versa - cancer cells express factors that modulate tumour milieu in terms of its composition and function. We performed an immunohistochemical (IHC) staining of 108 formalin-fixed, paraffin-embedded (FFPE) tissue samples to investigate the relationships between T-cell, B-cell, and NK-cell infiltrate, invasive breast carcinomas molecular subtypes, and other prognostic indicators...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351863/prognostic-significance-of-androgen-receptor-expression-in-her2-positive-and-triple-negative-breast-cancer
#8
Betul Bolat Kucukzeybek, Ibrahım V Bayoglu, Yuksel Kucukzeybek, Yasar Yıldız, Utku Oflazoglu, Murat K Atahan, Halıl Taskaynatan, Ahmet Alacacioglu, Seyran Yigit, Mustafa O Tarhan
Triple-negative breast cancer (TNBC) and HER2-positive breast cancer are more aggressive than other subtypes of breast cancer. Due to the limited number of treatment alternatives and the absence of target receptors in TNBC, and because of progression in the HER2-positive group despite targeted treatments, new treatment targets and therapeutic combinations are required. In this context, the present study aims to evaluate the prognostic importance of immunohistochemical androgen receptor (AR) expression in HER2-positive breast cancer and TNBC subtypes...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351862/influence-of-tnf-%C3%AE-promoter-variability-on-stage-and-grade-in-individuals-with-colorectal-cancer
#9
Michał Natkaniec, Jadwiga Dworak, Jerzy Hankus, Marek Sanak, Michał Pędziwiatr, Piotr Major, Sabina Lichołai, Andrzej Budzyński
Carcinogenesis is a multistep process in which inflammation plays an important role. Tumour necrosis factor a (TNF-α) is a cytokine that plays a major role in inflammation. Activity of the TNF cytokine family could influence progression of colorectal cancer (CRC). The aim of the study was to establish an association between TNF-α promoter variability and stage/grade in individuals with sporadic CRC. The study included 152 CRC patients and 107 healthy volunteers. Four single nucleotide polymorphisms (rs361525, rs1800629, rs1799724, and rs1799964) located at the promoter of TNFA gene were genotyped using commercially available TaqMan allelic discrimination assays by real-time PCR...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351861/association-between-her2-neu-status-in-colorectal-carcinoma-and-clinicopathological-features-a-retrospective-study-using-whole-tissue-sections
#10
Aydan Kılıçarslan, Hayriye Tatli Dogan, Nuran Süngü, Mehmet Dogan, Abdussamet Yalcin, Didem Şener Dede
The human epidermal growth factor receptor 2 (Her2/neu) signal pathway plays a significant role in the occurance of various solid tumor types. The rate of Her2/neu in colorectal carcinoma (CRC) is not clearly elucidated. In this study, we discuss the association between Her2/neu overexpression and clinicopathological parameters in CRC. Her2/neu immunohistochemical (IHC) staining was performed on whole sections of formalin fixed paraffin embedded tumor tissues of 100 CRC resections. Cases with score 3+ and score 2+ expressions were further evaluated by silver in-situ hybridization (ISH) for the existence of Her2/neu gene amplification...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351860/clinicopathological-and-fluorescence-in-situ-hibridisation-analysis-of-primary-testicular-diffuse-large-b-cell-lymphoma-a-single-centre-case-series
#11
Maja Perunicic Jovanovic, Biljana Mihaljevic, Petar Jovanovic, Jelena Jelicic, Vesna Cemerikic Martinovic, Jelica Jovanović, Marija Dencic Fekete, Milica Čekerevac, Nebojša Bojanić
Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) represents a rare and aggressive extranodal non-Hodgkin's lymphoma (NHL) with some specific features that differ from other NHLs. Formalin fixed, paraffin wax embedded (FFPE) samples of 21 PT-DLBCLs and 30 comparative patients with DLBCL were analysed. All PT-DLBCL patients were treated with rituximab-containing regimens, intrathecal prophylaxis (10 patients), and irradiation of the contralateral testis (9 patients). FFPE samples were additionally analysed by immunohistochemistry (Bcl-2, c-Myc protein expression) and fluorescence in situ hybridisation (FISH) (BCL2 and MYC)...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351859/clinicopathologic-study-of-10-cases-of-gastric-adenocarcinoma-with-hepatoid-or-enteroblastic-differentiation
#12
Naoto Kuroda, Kenji Yorita
Gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED), known also as AFP-producing carcinoma, is a rare neoplasm. Ten cases with GAHED and 209 cases without GAHED were selected. Clinicopathological features of GAHED were investigated. The disease-free survival (DFS) of the GAHED group was compared with that of the non-GAHED group. Grossly, the tumours consisted of two early types and eight advanced types. Histologically, all tumours were composed of various proportions of tubular, cribriform, papillary, solid, and/or trabecular growth patterns of clear to slightly eosinophilic tumour cells...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351858/an-insight-into-the-history-of-anatomopathological-museums-part-2
#13
Jacek Gulczyński, Piotr Paluchowski, Jacek Halasz, Adam Szarszewski, Marek Bukowski, Ewa Iżycka-Świeszewska
The second part of the comprehensive work concerning pathology museums and collections presents their history since the 19th century. The evolution and specialisation of museums, depending on the attitude of their creators and geographic localization, have been analysed. The changing aspects of obtaining the exhibits and how they were preserved, presented, and stored are also a part of this work. The methods of human organ fixation reached excellence in the 19th century, but the rarity of some pathologies urged the scientists to recreate them artificially in models for didactic purposes...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351857/where-are-we-with-polish-pathology-at-the-turn-of-the-centuries-in-the-light-of-the-congresses-of-the-polish-society-of-pathologists
#14
Andrzej Dzikowski, Józef Szarek, Dominika Gulda, Izabella Babińska, Mariusz Zbigniew Felsmann, Krystian Popławski, Beata Szynaka
The aim of this study is to depict the current and past research directions in Polish pathology at the turn of the centuries. The analysis was based on the abstracts of the congresses of the Polish Society of Pathologists organized in 1992-2016 and concerned 1,824 presentations. It has been proven that oncology (1,090 presentations, 59.76%) was the most commonly discussed topic and dominated the dispute. Organ pathology was the area of research covered with over ¼ of all papers (464 presentations, 25...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30351856/a-review-of-alk-rearranged-renal-cell-carcinomas-with-a-focus-on-clinical-and-pathobiological-aspects
#15
Naoto Kuroda, Emiko Sugawara, Hironori Kusano, Yoshiaki Yuba, Kenji Yorita, Kengo Takeuchi
ALK-rearranged renal cell carcinoma (ALK-RCC) has been recently proposed and incorporated into the recent World Health Organisation Classification of renal tumours as a provisional entity. In this article, we review ALK-RCC with a focus on clinical and pathobiological aspects. Seventeen cases have been described to date. ALK-RCC accounts for less than 1% of all renal tumours. The age of patients ranges from 6 to 61 years with a mean age of 29.6 years. Grossly, the tumour forms were ill-demarcated or well demarcated solid mass in the renal medulla...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895134/lymphoepithelioma-like-breast-carcinoma
#16
REVIEW
Nektarios Koufopoulos, John Syrios, Asimina Papanikolaou, Ioannis Misitzis, Kasiani A Kapatou, Dionysis Dimas, Lubna Khaldi
Nasopharyngeal lymphoepithelioma is an undifferentiated carcinoma in a dominated lymphoplasma-histiocyte stroma. Lymphoepithelioma-like carcinoma of the breast is the mammary counterpart of the lymphoepithelioma of the nasopharynx and is characterised by proliferation of poorly differentiated malignant cells within a prominent lymphoid infiltrate. It is a very rare primary carcinoma of the breast first reported in 1994 by Kumar and Kumar. Fewer than 40 cases have been reported in the English literature. In this manuscript a case of lymphoepithelioma-like carcinoma of the breast in a 57-year-old patient is reported along with a literature review on this rare entity...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895133/keloidal-like-local-recurrence-after-infiltrating-adenosquamous-breast-carcinoma-with-stromal-overgrowth-mimicking-a-benign-skin-lesion
#17
Simona Stolnicu, Alexandra Giurgi, Adrian Naznean, Cristian Podoleanu, Anca Chiriac
We present a very rare case of an adenosquamous infiltrating breast carcinoma with sarcomatous stromal overgrowth of hypocellular collagenised type, which subsequently developed local recurrence, mistaken for a benign skin lesion due to bland keloid-like morphological appearance. All the histological, immunohistochemical, and clinical features must be taken into consideration when distinguishing between a benign skin lesion and a local recurrence of a rare subtype of breast carcinoma.
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895132/lymphoepithelioma-like-carcinoma-of-the-endometrium-case-report-of-a-rare-tumour-with-comprehensive-immunohistochemical-and-molecular-analysis
#18
Kristýna Němejcová, Nikola Hájková, Ivana Tichá, Michaela Bártů, Dagmar Dolínská, Vladimír Kalist, Pavel Dundr
We are reporting a case of endometrial lymphoepithelioma-like carcinoma (LELC) in a 63-year-old female. Microscopically, the tumor consisted of groups of tumor cells surrounded by dense lymphoplasmacytic infiltrate. Immunohistochemically, the tumour cells were positive for cytokeratins AE1/AE3, EMA, PAX8, p16, and estrogen receptors. Protein p53 showed an aberrant type of expression. Molecular genetic analysis revealed mutations in the TP53 and PIKP53CA genes. Based on our results, we believe that the tumor represents an unusual morphological variant of endometrial serous carcinoma...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895131/incidental-low-fat-variant-of-spindle-cell-lipoma-a-novel-tumour-of-the-small-intestine
#19
J Fernando Val-Bernal, Sandra Hermana, José-Javier Gómez-Román
A woman underwent surgical intervention for a carcinoma of the ovary. In the intervention, a submucosal nodule of the ileum was found. Pathological study revealed a spindle cell lipoma (SCL). This case revealed the presence of CD34-positive spindle and stellate cells with dendritic cytoplasmic prolongations, a feature shared with dendritic fibromyxolipoma. Fluorescence in <i><i><i>in situ</i></i></i> hybridisation analysis showed 13q14 heterozygous deletion. Spindle cell lipoma of the small intestine has not been previously reported...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29895130/single-nucleotide-polymorphisms-of-xrcc3-gene-in-hepatocellular-carcinoma-relationship-with-clinicopathological-features
#20
Elena-Roxana Avadanei, Simona-Eliza Giusca, Lucian Negura, Irina-Draga Caruntu
Recent studies support the involvement of XRCC3 gene polymorphisms in carcinogenesis. Our study focuses on the identification of polymorphic variants of XRCC3 in hepatocellular carcinoma (HCC) and an analysis of the relationship between these polymorphic variants and clinicopathological (including the genotype specific risk) and survival characteristics. Fifty cases of HCC were genotyped using molecular biology techniques for Thr241Met, rs861539 (c.722C>T) and 5'-UTR, rs1799796 (c.562-14A>G) polymorphisms...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
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