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Folia Neuropathologica

Carl Moritz Zipser, Lars Füllbier, Rudi Beschorner, Hans Bösmüller, Ulf Ziemann, Marcos Soares Tatagiba, Ghazaleh Tabatabai, Benjamin Bender, Felix Behling
We report the case of a 78-year-old male patient suffering from right temporal glioblastoma with radiographic meningeal tumor spread. During the further course of the disease he developed a rapidly progressive paraplegia. An magnetic resonance imaging scan showed a contrast enhancing an intraspinal intradural lesion with compression of the myelon on segment Th 8/9. With a high suspicion of a spinal metastasis of the known glioblastoma, emergency spinal decompression and resection of the intradural mass was performed...
2018: Folia Neuropathologica
Ramazan Üstün, Elif Kaval Oğuz
Ankaferd Blood Stopper® (ABS) is a licensed medicinal herbal extract that ensures effective hemostasis on external, internal, postoperative and dental bleeds. Dorsal root ganglia (DRG) harbor cell bodies of peripheral sensory neurons. DRG neurons receive peripheral information and regularly send projections to nuclei in the brainstem and the spinal cord. These neurons play critical roles in neural development. Neuronal dysfunctions were reported due to ABS use in surgical interventions. The purpose of this experiment was to investigate the degenerative effects of the ABS on mice DRG cells <I>in vitro</I>...
2018: Folia Neuropathologica
Kaveh Tabrizian, Mahmoud Hashemzaei, Ali Akbar Nasiri, Sheyda Najafi, Fatemeh Amelinia, Mehdi Sanati, Farzaneh Shamshirgaran, Sahar Fanoudi
INTRODUCTION: Accumulated evidence shows that the cAMP-PKA signaling pathway plays a key role in memory functions. Cyclooxygenase-2, a critical player in neuroinflammation, has been confirmed in the pathogenesis of neurodegenerative diseases. This study is aimed to assess the effect of the interaction of cAMP-PKA and cyclooxygenase pathways on spatial memory acquisition in animal models. MATERIAL AND METHODS: In the present study, the effects of the four-day bilateral intra-hippocampal infusions of H-89 as a protein kinase AII inhibitor (10 µM/side), celecoxib (0...
2018: Folia Neuropathologica
She-Jun Feng, Xue-Qiang Zhang, Jun-Tao Li, Xiao-Min Dai, Fei Zhao
Cerebral ischemia injury seriously endangers human health and its molecular mechanism is still not fully understood. microRNA-223 (miR-223) has been reported to be involved in many physiological functions but the specific role of miRNA-223 in ischemic neuronal injury is still unclear. An oxygen-glucose deprivation and simulated reperfusion (OGD/R) model was constructed here to investigate the possible role miR-223 played in ischemic neuronal injury. The expression of miRNA-223 in the OGD/R model and its effect on cell proliferation were studied by qPCR and CCK8 assay...
2018: Folia Neuropathologica
Khaled Radad, Mubarak Al-Shraim, Ahmed Al-Emam, Rudolf Moldzio, Wolf-Dieter Rausch
INTRODUCTION: Domoic acid is a potent marine neurotoxin produced by certain species of the diatom genus Pseudonitzschia. To our knowledge, there are no studies that have investigated neurotoxic effects of domoic acid on dopaminergic neurons. Accordingly, the present study was carried out to investigate the potential neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture. MATERIAL AND METHODS: Cultures prepared from embryonic mouse mesencephala (total of 250 embryos) were treated with different concentrations of domoic acid (0...
2018: Folia Neuropathologica
Yihong Chen, Hongxiang Wang, Cong Tan, Yong Yan, Junyan Shen, Qilin Huang, Tao Xu, Junting Lin, Juxiang Chen
The purpose of this study was to investigate the expression status of amyloid precursor-like protein 2 (APLP2) and its clinical relevance in patients with glioblastoma. The publically available database Project Betastasis involving Repository for Molecular Brain Neoplasia Data (REMBRANDT) and The Cancer Genome Atlas (TCGA) was first utilized to analyze the expression and prognostic potential of APLP2 in glioblastoma. Compared with normal controls, the glioblastoma group from each dataset showed no significant difference of APLP2 expression (p > 0...
2018: Folia Neuropathologica
Wang Li, Chunyang Geng, Bo Liu
Synaptic vesicle (SV) will be transported to the bouton along the axon, once it is formed in a cell body. After docking in the active zone, neurotransmitters will be released upon the stimulation, and then transmission of chemical signals will be initiated. Presently, many advanced technologies and burgeoning molecular sensors are being used to explore the synaptic transmission. These studies provide a new sight into the presynaptic structure and its function. The present review summarizes the application of fluorescent proteins (FPs) for SV tracking and recycling...
2018: Folia Neuropathologica
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwar
In elderly population, Alzheimer's disease is a common neurodegenerative disorder and accounts for about 70% of all cases of dementia. The neurodegenerative processes of this disease start presumably 20 years ahead of the clinical beginning of the disorder. The postmortem histopathological examination, brains from Alzheimer's disease patients with characteristic features like amyloid plaques and neurofibrillary tangles, neuronal and synaptic disintegration confirm the final diagnosis of Alzheimer's disease...
2018: Folia Neuropathologica
Richard A Armstrong
A variety of methods are available for the quantitative description and analysis of neurodegenerative disease. If neurodegenerative disease exists as a series of distinct disorders, then classificatory methods such as hierarchical cluster analysis (HCA) and decision tree analysis (DTA) can be used to classify cases into groups more objectively. If neurodegenerative disease consists of overlapping phenotypes, then the Braun-Blanquet 'nodal' system and 'constellation diagrams' implicitly recognise intermediate cases and reveal their relationships to the main groupings...
2018: Folia Neuropathologica
Hamid Reza Sadeghnia, Arezoo Rajabian, Ahmad Ghorbani, Maliheh Moradzadeh, Azar Hosseini
<i>Glutamate is one of the major excitatory neurotransmitters in the central nervous system. Increasing glutamate leads to neurodegenerative disease. Nowadays, plant medicine plays a role in the treatment of some disorders. In this research, we investigated the neuroprotective effect of <I>Ferula gummosa</I> root extract against glutamate-induced oxidative stress in the rat adrenal pheochromocytoma (PC12) and mouse neuroblastoma (N2a) cell lines. The cells were pretreated with extract for 2 h and then exposed to glutamate for 24 h...
2017: Folia Neuropathologica
Tomasz Stępień, Ewa Taracha, Ewelina Kaniuga, Adam Płaźnik, Teresa Wierzba-Bobrowicz
<i>In our study expression of phospho-(Ser-10)-histone H3 (pH3S10), a marker for the early stage of neurogenesis, and cellular early response genes were investigated using c-Fos protein as an example of a transcription factor in the neurogenic process in rats. Neurogenesis in the adult brain is regulated by endo- and exogenous factors, which influence the proliferation potential of progenitor cells and accelerate the dendritic development of newborn neurons. D-amphetamine, a psychoactive substance, is one of the exogenous factors able to influence the process of neurogenesis...
2017: Folia Neuropathologica
Kaja Kasarełło, Anika Jesion, Karolina Tyszkowska, Katarzyna Matusik, Katarzyna Czarzasta, Robert Wrzesień, Agnieszka Cudnoch-Jedrzejewska
<i>Multiple sclerosis (MS) is an autoimmunological disease leading to neurodegeneration. The etiology of the disease remains unknown, which strongly impedes the development of effective therapy. Most MS treatments focus on modulating the activity of the immune system. Dimethyl fumarate (DMF) exerts a broad spectrum of action, such as modulating immune cell differentiation towards anti-inflammatory subtypes, influencing cytokine production, regulating immune cell migration into the central nervous system, and activating intracellular antioxidant mechanisms...
2017: Folia Neuropathologica
Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Chen
<i><B>Introduction</B>: Maternal hypoxia induces an adverse uterine environment and may induce long-term effects in offspring. This study investigated whether maternal hypoxia increases hippocampal cell vulnerability and exacerbates neurological impairments in adult rat offspring following ischemia. <B>Material and methods</B>: Pregnant Sprague-Dawley rats were randomly assigned to no maternal hypoxia or maternal hypoxia treatment groups. Adult male rat offspring were subjected to middle cerebral artery occlusion (MCAO)...
2017: Folia Neuropathologica
Huiyu Zhang, Minfang Guo, Lihong Zhang, Huiqing Xue, Zhi Chai, Yuqing Yan, Yanxia Xing, Baoguo Xiao, Peijun Zhang, Cungen Ma
<i>Huangqi glycoprotein (HQGP) is prepared from Astragalus membranaceus by ammonium sulfate precipitation. It was indicated that HQGP has an immunoregulatory effect. In this study, we established a chronic experimental autoimmune encephalomyelitis (EAE) model and observed the therapeutic effect and possible mechanisms of HQGP (intraperitoneally at 1 mg/kg/day) on EAE. The results showed that HQGP delayed onset and ameliorated severity of EAE, and reduced the infiltration and accumulation of pathogenic T cells in the central nerves system (CNS)...
2017: Folia Neuropathologica
Kinga Czubowicz, Mariusz Głowacki, Ewa Fersten, Ewa Kozłowska, Robert P Strosznajder, Zbigniew Czernicki
<i>Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) absorption and treated by surgical shunt insertion. The early diagnosis of NPH is difficult because of various manifestations of the disease. One of the most promising research directions is biochemical CSF analysis. The aim of this study was to determine the CSF levels of cytokines. The levels of various cytokines (IL-6, IL-8, IL-12, IL-10 and TNF-α) were measured in patients with idiopathic active normal pressure hydrocephalus, arrested hydrocephalus and hydrocephalus with brain atrophy compared to controls...
2017: Folia Neuropathologica
Dorota Dziewulska, Dorota Sulejczak, Michalina Wężyk
<i>We report patients from a Polish family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) who possess a novel heterozygous R110C mutation in exon 3 of the NOTCH3 gene leading to stereotypical cysteine loss. The proband had only seizure attacks and her magnetic resonance imaging (MRI) showed very numerous hyperintense foci in the cerebral white matter in a location characteristic of CADASIL. Distinctive ultrastructural assessment of vessels from skin-muscle biopsy revealed only mild degenerative changes but relatively numerous homogeneous deposits of granular osmiophilic material (GOM)...
2017: Folia Neuropathologica
Pawel P Liberski, Agata Gajos, Andrzej Bogucki
<i>We report here autophagy in the optic nerve in experimental Gerstmann-Sträussler-Scheinker disease (GSS) (Fujisaki-1) in mice and experimental Creutzfeldt-Jakob disease (CJD) (Echigo-1) in hamsters. Lesions of both experimental GSS in mice and experimental CJD in hamsters were practically indistinguishable. Briefly, they consisted of widespread Wallerian degeneration, spongiform change and a glial reaction. Numerous axonal swellings were seen. The latter were filled with numerous mitochondria and lysosomal electron-dense bodies...
2017: Folia Neuropathologica
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwar
<i>Cardiac arrest, usually occurring in the aged population, is the most important cause of high morbidity and death in developed countries. Commonly, attention, depression, cognitive impairment, spatial memory, short- and long-term memory, executive functions, decreased quality of life and social participation are disturbed following circulation arrest. Deficits in cognitive function, similar to prodromal Alzheimer's disease dementia, following cardiac arrest remain an area of concern. Recent research has focused on the post-resuscitation period to identify mechanisms of long-term brain damage and cognitive impairment...
2017: Folia Neuropathologica
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2017: Folia Neuropathologica
Tadeusz A Mendel, Beata Błażejewska-Hyżorek, Grażyna M Szpak, Tomasz Stępień, Eliza Lewandowska, Sylwia Tarka, Iwona Kurkowska-Jastrzębska, Teresa Wierzba-Bobrowicz
In patients with cerebral venous thrombosis (CVT) the incidence of intracerebral hemorrhage (ICH) is estimated at about 37% and subarachnoid hemorrhage (SAH) at 1% of patients. A case with coincident occurrence of ICH, SAH and CVT in a patient with cerebral amyloid angiopathy (CAA) is reported. A 79-year-old woman was admitted to the Neurological Department after the occurrence of generalized seizures, the first in her life. On admission she was unconscious with right hemiparesis and deviation of eyes to the left...
2017: Folia Neuropathologica
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