journal
MENU ▼
Read by QxMD icon Read
search

Folia Neuropathologica

journal
https://www.readbyqxmd.com/read/28984119/neurochemical-conference-2017-advances-in-molecular-and-epigenetic-mechanisms-in-neurodegeneration-and-neuroinflammation-novel-therapeutic-approaches
#1
(no author information available yet)
No abstract text is available yet for this article.
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984118/intracerebral-hemorrhage-in-the-context-of-cerebral-amyloid-angiopathy-and-varied-time-of-onset-of-cerebral-venous-thrombosis-a-case-report
#2
Tadeusz A Mendel, Beata Błażejewska-Hyżorek, Grażyna M Szpak, Tomasz Stępień, Eliza Lewandowska, Sylwia Tarka, Iwona Kurkowska-Jastrzębska, Teresa Wierzba-Bobrowicz
In patients with cerebral venous thrombosis (CVT) the incidence of intracerebral hemorrhage (ICH) is estimated at about 37% and subarachnoid hemorrhage (SAH) at 1% of patients. A case with coincident occurrence of ICH, SAH and CVT in a patient with cerebral amyloid angiopathy (CAA) is reported. A 79-year-old woman was admitted to the Neurological Department after the occurrence of generalized seizures, the first in her life. On admission she was unconscious with right hemiparesis and deviation of eyes to the left...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984117/sudden-unexpected-postnatal-collapse-at-20-hours-from-birth-during-skin-to-skin-care-related-to-brainstem-developmental-alterations-a-case-report
#3
Anna M Lavezzi, Francesco Piscioli, Teresa Pusiol
This report describes a case of sudden collapse of a 20-hour-old newborn, while he was placed close to their mother according to skin-to-skin care, attributed to developmental alterations of brainstem nuclei involved in regulation of the vital functions. The infant, after a normal pregnancy, appeared well developed at birth, with no evidence of malformations or trauma, but showing severe asphyxia. The routine autopsy did not reveal a possible cause of death. Only the in-depth anatomopathological examination of the autonomic nervous system, according to the protocol developed by the "Lino Rossi" Research Center of Milan University, provided an explanation of the pathogenetic mechanism of this early death...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984116/cerebellar-liponeurocytoma-with-atypical-histological-features-a-rare-example-of-a-glioneuronal-tumor
#4
Blanka Hermann, Michal Woznica, Wojciech Kloc, Piotr Borkowski, Witold Libionka, Ewa Izycka-Swieszewska
We present a case of a rare neoplasm in a 77-year-old woman with previous oncological history, who developed a rapid onset of cerebellar symptoms. The neuroimaging detected a posterior fossa tumor suspected of meningioma which was completely resected soon after. Histologically the neoplasm had two components with different immunophenotype. One constituent was lobular, composed of monotonous mitotically active round cells with a predominant neuronal profile. The second, astrocytic component contained lipomatous cells intermixed with larger gemistocytic astrocytes...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984115/ebv-positive-post-transplant-lymphoproliferative-disorder-presenting-as-primary-diffuse-large-b-cell-lymphoma-of-the-central-nervous-system
#5
Haoliang Xu, Julia Rewerska, Nathan Aardsma, Konstantin Slavin, Tibor Valyi-Nagy, Hongyu Ni
Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare complication with inferior survival outcomes in solid organ transplant patients. It represents approximately 7-15% of all PTLD patients. Because of the rarity of this disease, the diagnosis of PCNS-PTLD is often challenging, and the optimal therapy has not been established. We report a case of a renal transplant patient who initially presented with acute altered neurological function, an enhancing mass lesion of the brain on magnetic resonance imaging (MRI), and nonspecific reactive histopathological changes on brain biopsy...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984114/a-novel-de-novo-col6a1-mutation-emphasizes-the-role-of-intron-14-donor-splice-site-defects-as-a-cause-of-moderate-progressive-form-of-colvi-myopathy-a-case-report-and-review-of-the-genotype-phenotype-correlation
#6
Agnieszka A Koppolu, Agnieszka Madej-Pilarczyk, Małgorzata Rydzanicz, Joanna Kosińska, Piotr Gasperowicz, Jolanta Dorszewska, Wojciech Kozubski, Barbara Steinborn, Andrzej M Kochański, Rafał Płoski
Collagen VI-related myopathy is a group of disorders affecting skeletal muscles and connective tissue. The most common symptoms are muscle weakness and joint deformities which limit the movement and progress over time. Several forms of collagen VI-related myopathies have been described: Bethlem myopathy, an intermediate form and Ullrich congenital muscular dystrophy, which is the most severe. Here we report a novel de novo c.1056+3A>C substitution in intron 14 of the COL6A1 gene encoding alpha-chains of collagen VI in a 13-year-old girl suffering from collagen VI (ColVI) myopathy...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984113/neuroprotective-effect-of-safranal-an-active-ingredient-of-crocus-sativus-in-a-rat-model-of-transient-cerebral-ischemia
#7
Hamid R Sadeghnia, Hamideh Shaterzadeh, Fatemeh Forouzanfar, Hossein Hosseinzadeh
Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery occlusion for 30 min, followed by 24 h of reperfusion. Safranal in the doses of 72.5 and 145 mg/kg was administered intraperitoneally at 0, 3, and 6 h after reperfusion...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984112/effects-of-green-tea-epigallocatechin-3-gallate-on-the-proteolipid-protein-and-oligodendrocyte-transcription-factor-1-messenger-rna-gene-expression-in-a-mouse-model-of-multiple-sclerosis
#8
Mohammadreza Semnani, Farhad Mashayekhi, Mahnaz Azarnia, Zivar Salehi
The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. It has been shown that green tea epigallocatechin-3-gallate (EGCG) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. In this study the effects of EGCG on proteolipid protein (PLP) and oligodendrocyte transcription factor 1 (Olig1) expression in the cerebral cortex of a murine model of cuprizone-induced demyelination was investigated...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984111/dysfunctional-lamins-as-mediators-of-oxidative-stress-in-emery-dreifuss-muscular-dystrophy
#9
Irena Niebroj-Dobosz, Beata Sokołowska, Agnieszka Madej-Pilarczyk, Michał Marchel, Irena Hausmanowa-Petrusewicz
Deficit of lamin A/C or emerin causes genetically transmitted Emery-Dreifuss muscular dystrophy (EDMD). As lamins are considered to be mediators of oxidative stress, the antioxidant/oxidant status was examined. The total oxidant/antioxidant status in serum was examined in 29 cases of Emery-Dreifuss muscular dystrophy. The study included 12 autosomal-dominant laminopathies (AD-EDMD), 17 X-linked emerinopathies (X-EDMD) and 20 age-matched normal subjects. Total oxidant status (TOS) was reduced in all cases, and the total antioxidant capacity (TAC) was found to be decreased in the majority of the patients (in 82...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984110/neuronal-cytoplasmic-inclusions-in-tau-tdp-43-and-fus-molecular-subtypes-of-frontotemporal-lobar-degeneration-share-similar-spatial-patterns
#10
Richard A Armstrong
The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders. Hence, the spatial patterns of the NCI were compared in three molecular subtypes of FTLD: (1) two variants of FTLD-tau, viz. cortico-basal degeneration (CBD) and Pick's disease (PiD), (2) FTLD with transactive response (TAR) DNA-binding protein 43(TDP-43)-immunoreactive inclusions (FTLD-TDP), and (3) FTLD with 'fused in sarcoma' (FUS)-immunoreactive inclusions (FTLD-FUS)...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28984109/in-memoriam-professor-janina-rafa%C3%A5-owska
#11
Dorota Dziewulska, Ewa Matyja, Milena Laure-Kamionowska
No abstract text is available yet for this article.
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677375/high-expression-of-cx3c-chemokine-receptor-1-cx3cr1-in-human-carotid-plaques-is-associated-with-vulnerability-of-the-lesions
#12
Marta Masztalewicz, Przemysław Nowacki, Łukasz Szydłowski, Maciej Żukowski, Piotr Gutowski
<i><b>Introduction</b>: In data based on ex vivo studies and animal models, fractalkine is considered an important mediator in the development and destabilization of atherosclerotic plaques. We do not know how it is associated with human carotid plaques morphology. <b>Material and methods</b>: The study included 126 carotid plaques taken from 126 patients who underwent endarterectomy of internal carotid arteries. We assessed the following characteristics: inflammatory infiltration, connective tissue elements, foam cells, lipid core, plaque vascularisation, calcifications, intraplaque haemorrhage, thrombi built into the plaque structure, and mural thrombi...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677374/retinal-ganglion-cell-inner-plexiform-layer-thickness-in-patients-with-parkinson-s-disease
#13
Maja Živković, Volkan Dayanir, Jelena Stamenović, Srdjan Ljubisavljević, Ana Pražić, Marko Zlatanović, Gordana Zlatanović, Vesna Jakšić, Marija Radenković, Svetlana Jovanović
<i><b>Introduction: </b> The aim of the paper was to analyze the changes in the macular ganglion cell layer and inner plexiform layer (GCL-IPL) thickness in patients with Parkinson's disease. <b>Material and methods</b>: The study enrolled 46 patients with established diagnosis of Parkinson's disease and 46 healthy subjects. Both groups were age- and gender-matched. An OCT protocol, namely standardized Ganglion Cell Analysis algorithm was used to measure the thickness of the macular GCL-IPL layer...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677373/commitment-of-protein-p53-and-amyloid-beta-peptide-a%C3%AE-in-aging-of-human-cerebellum
#14
Danuta Maślińska, Milena Laure-Kamionowska, Dariusz Szukiewicz, Sławomir Maśliński, Krystyna Księżopolska-Orłowska
Protein p53 is known to induce the cell cycle arrest and apoptosis in response to a variety of cellular distress signals and DNA damage. A recent study has demonstrated that in blood cells of aging subjects, p53 may induce early pathological changes that precede the amyloidogenic cascade. However, it is not clear whether p53 participates in the local deposition of amyloid-beta peptide (Aβ) in the nerve tissue of normal aging subjects. Therefore, in the present study, we analyse the distribution of both (Aβ and p53) proteins in the cerebellum of individuals without any history of dementia or other neurological illness who died suddenly in traffic accidents...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677372/early-increased-density-of-cyclooxygenase-2-cox-2-immunoreactive-neurons-in-down-syndrome
#15
Maria Mulet, José Miguel Blasco-Ibáńez, Carlos Crespo, Juan Nácher, Emilio Varea
<i>Neuroinflammation is one of the hallmarks of Alzheimer's disease. One of the enzymes involved in neuroinflammation, even in early stages of the disease, is COX-2, an inducible cyclooxygenase responsible for the generation of eicosanoids and for the generation of free radicals. Individuals with Down syndrome develop Alzheimer's disease early in life. Previous studies pointed to the possible overexpression of COX-2 and correlated it to brain regions affected by the disease. We analysed the COX-2 expression levels in individuals with Down syndrome and in young, adult and old mice of the Ts65Dn mouse model for Down syndrome...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677371/neuropathological-characteristics-of-the-brain-in-two-patients-with-slc19a3-mutations-related-to-the-biotin-thiamine-responsive-basal-ganglia-disease
#16
Maciej Pronicki, Dorota Piekutowska-Abramczuk, Elżbieta Jurkiewicz, Dariusz Rokicki, Elżbieta Ciara, Joanna Trubicka, Katarzyna Iwanicka-Pronicka, Magdalena Pajdowska, Marek Migdał, Wieslawa A Grajkowska
<i>Biotin-thiamine-responsive basal ganglia disease is a severe form of a rare neurogenetic disorder caused by pathogenic molecular variants in the thiamine transporter gene. Nowadays, a potentially effective treatment is known, therefore the early diagnosis is mandatory. The aim of the paper was to assess the contribution of neuropathological and magnetic resonance imaging (MRI) studies to a proper diagnosis. We present the brain study of two Polish patients with SLC19A3 mutations, including (1) an infant with an intriguing "walnut" appearance of the brain autopsied many years before the discovery of the SLC19A3 defect, and (2) a one-year-old patient with clinical features of Leigh syndrome...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677370/neuronal-vacuolation-and-spinocerebellar-degeneration-associated-with-altered-neurotransmission
#17
Aggeliki Giannakopoulou
<i>Inherited neurodegenerative disorders are debilitating diseases that occur across different species, such as the domestic dog (Canis lupus familiaris), and many are caused by mutations in the same genes as corresponding human conditions. In the present study, we report an inherited neurodegenerative condition, termed 'neuronal vacuolation and spinocerebellar degeneration' (NVSD) which affects neonatal or young dogs, mainly Rottweilers, which recently has been linked with the homozygosity for the RAB3GAP1:c...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677369/propofol-attenuates-intermittent-hypoxia-induced-up-regulation-of-proinflammatory-cytokines-in-microglia-through-inhibiting-the-activation-of-nf-b%C3%AE%C2%BA-p38-mapk-signalling
#18
Song Liu, Jin-Yuan Sun, Lian-Ping Ren, Kui Chen, Bo Xu
<i>As immune sentinels of the central nervous system (CNS), microglia is pivotal cellular mediator of neuroinflammatory processes. Activation of microglia might elicit the expression of proinflammatory cytokines involved in the progression of neuroinflammatory diseases. Numerous studies have demonstrated that propofol (2,6-diisopropylphenol) has an effective anti-inflammatory property. Intermittent hypoxia (IH), as a result of obstructive sleep apnoea (OSA), could lead to neuron damage and neuroinflammation in the CNS...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677368/functional-properties-of-different-collagen-scaffolds-to-create-a-biomimetic-niche-for-neurally-committed-human-induced-pluripotent-stem-cells-ipsc
#19
Krystyna Pietrucha, Marzena Zychowicz, Martyna Podobinska, Leonora Buzanska
<i>The biomimetic, standardized conditions for <i><i><i><i><i>in vitro</i></i></i></i></i> cultures of human neural progenitors derived from induced pluripotent stem cells (hiPSC-NPs) should meet the requirements to serve as the template and protective environment for therapeutically competent cell population. In this study, two different collagen scaffolds: bi-component consisting of collagen and chondroitin sulphate (Col-CS), and collagen modified by crosslinking agent 2,3-dialdehyde cellulose (Col-DAC) have been used for the first time to encapsulate hiPSC-NPs and compared for the ability to create permissive microenvironment enabling cell survival, growth and differentiation...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28677367/neurologic-complications-in-kidney-transplant-recipients
#20
Piotr C Piotrowski, Anna Lutkowska, Alexander Tsibulski, Marek Karczewski, Paweł P Jagodziński
<i>Transplantology experiences continuous growth and kidney transplantation is the most frequently transplanted solid organ. Metabolic, cardiovascular, infectious or kidney function-related aspects are widely recognised and are of key interest for transplant doctors. Neurological complications seen in these patients, although known, are less covered in the literature. According to some reports, neurologic symptoms are experienced by almost 9 per 10 transplant recipients. The intensity, severity and type of abnormalities may vary, and most frequently the complications seem to be associated with a direct or indirect effect of immunosuppressive medications, including their direct effect on cells, on blood vessels, and susceptibility to infections...
2017: Folia Neuropathologica
journal
journal
32041
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"