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Journal of Bone and Mineral Metabolism

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https://www.readbyqxmd.com/read/29785666/evaluation-of-ostarine-as-a-selective-androgen-receptor-modulator-in-a-rat-model-of-postmenopausal-osteoporosis
#1
D B Hoffmann, M Komrakova, S Pflug, M von Oertzen, D Saul, L Weiser, T A Walde, M Wassmann, A F Schilling, W Lehmann, S Sehmisch
Selective androgen receptor modulators (SARMs) have shown beneficial effects on muscle wasting, general physical function and bone properties in male mammals. However, data on the effects of SARMs in postmenopausal osteoporotic bone are scarce. We evaluated the effects of the SARM drug ostarine on postmenopausal osteoporotic bone in a rat osteoporosis model. Ovariectomy was performed on 46 of 56 3-month-old female Sprague-Dawley rats. Eight weeks after ovariectomy, ostarine was orally administered daily for 5 weeks in dosages of 0...
May 21, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29737412/factors-associated-with-inadequate-responses-to-risedronate-in-japanese-patients-with-osteoporosis
#2
Ryo Okazaki, Ryoichi Muraoka, Masayuki Maehara, Daisuke Inoue
Factors associated with an inadequate response (IR) to bisphosphonates have been reported in many countries, but not in Japan, where the approved dose is half the global dose. We analyzed factors associated with IR to risedronate in Japanese patients with osteoporosis. This was a post hoc analysis of 1261 Japanese osteoporosis patients who received risedronate for 1 year in phase III trials. IR was defined as more than one new vertebral fracture (VF) and/or negative change in lumbar spine bone mineral density (BMD) at 1 year...
May 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29721809/gushukang-exerts-osteopreserve-effects-by-regulating-vitamin-d-and-calcium-metabolism-in-ovariectomized-mice
#3
Xiao-Li Li, Liang Wang, Xiao-Lei Bi, Bing-Bing Chen, Yan Zhang
Calcium homeostasis plays vital roles in the management of bone health. Traditional herbal formula Gushukang (GSK) was clinically applied to treat primary osteoporosis. This study aimed to explore the osteoprotective effects of GSK and its roles in maintaining calcium homeostasis in ovariectomized (OVX) mice. The OVX mice were orally treated with low (0.38 g/kg), middle (0.76 g/kg) and high (1.52 g/kg) dose of GSK for 8 weeks. GSK treatment dramatically increased serum calcium level and decreased urinary calcium excretion as well as enhanced calcium content in bone of OVX mice...
May 2, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29721808/the-characteristics-of-clinical-changes-in-primary-hyperparathyroidism-in-chinese-patients
#4
Xiao-Ai Yao, Bo-Jun Wei, Tao Jiang, Hong Chang
In Western countries, the presentation of primary hyperparathyroidism (PHPT) changed from a symptomatic to an asymptomatic disease after the 1970s, whereas in China, only one study has evaluated the changing clinical characteristics and biochemical profiles of PHPT patients. The aim of this study was to explore changes in the clinical characteristics of PHPT in Chinese patients. Overall, 140 consecutive patients with PHPT were studied between January 1, 2010 and June 30, 2016. The patients were divided into two groups: 32 consecutive patients from January 1, 2010 to March 31, 2013 were included in group 1, and 108 consecutive patients from April 1, 2013 to June 30, 2016 were included in group 2...
May 2, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29721807/potential-association-with-early-changes-in-serum-calcium-level-after-starting-or-switching-to-denosumab-combined-with-eldecalcitol
#5
Tsuyoshi Asano, Tomohiro Shimizu, Daisuke Takahashi, Masahiro Ota, Dai Sato, Hiroki Hamano, Shigeto Hiratsuka, Masahiko Takahata, Norimasa Iwasaki
The aims of this study are to investigate changes in serum calcium (Ca) level after switching from either non-therapy, bisphosphonate, selective estrogen receptor modulators (SERM) or teriparatide treatments to a combination therapy of denosumab (DMAb), and eldecalcitol, and the association between early changes in serum calcium and changes in bone metabolic markers and bone mineral density (BMD). 129 patients with postmenopausal osteoporosis (32 non-pretreatment, 50 bisphosphonates, 18 SERM, and 29 teriparatide) were recruited and switched to DMAb plus eldecalcitol...
May 2, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29721806/optimal-administration-frequency-and-dose-of-teriparatide-for-acceleration-of-biomechanical-healing-of-long-bone-fracture-in-a-mouse-model
#6
Masahiro Ota, Masahiko Takahata, Tomohiro Shimizu, Daisuke Momma, Hiroki Hamano, Shigeto Hiratsuka, Norio Amizuka, Tomoka Hasegawa, Norimasa Iwasaki
Despite preclinical studies demonstrating the effectiveness of teriparatide for skeletal repair in small animals, inconclusive data from clinical trials have raised questions regarding the optimal teriparatide dosing regimen for bone repair. To address this, we assessed the effect of teriparatide frequency and dose on long-bone healing using a mouse femur osteotomy/fracture model. Eight-week-old male ICR mice were subjected to open femur osteotomies, then randomized into following five groups (n = 8 per group): vehicle; low dose/high frequency: 3 μg/kg/dose, 3 times/day; low dose/low frequency: 9 μg/kg/dose, 1 time/day; high dose/high frequency: 9 μg/kg/dose, 3 times/day; high dose/low frequency: 27 μg/kg/dose, 1 time/day...
May 2, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29671044/comparison-of-femur-stiffness-measured-from-dxa-and-qct-for-assessment-of-hip-fracture-risk
#7
Yunhua Luo, Huijuan Yang
Femur stiffness, for example axial and bending stiffness, integrates both geometric and material information of the bone, and thus can be an effective indicator of bone strength and hip fracture risk. Femur stiffness is ideally measured from quantitative computed tomography (QCT), but QCT is not recommended for routine clinical use due to the public concern about exposure to high-dosage radiation. Dual energy X-ray absorptiometry (DXA) is currently the primary imaging modality in clinic. However, DXA is two-dimensional and it is not clear whether DXA-estimated stiffness has adequate accuracy to replace its QCT counterpart for clinical application...
April 18, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29667007/failure-in-diagnosis-and-under-treatment-of-osteoporosis-in-elderly-patients-with-fragility-fractures
#8
Sofia Bougioukli, Panagoula Κollia, Theodora Koromila, Sokratis Varitimidis, Michael Hantes, Theofilos Karachalios, Κonstantinos Ν Malizos, Zoe H Dailiana
We evaluated whether osteoporosis is adequately managed and treated in patients suffering from fragility fractures. Factors that influenced osteoporosis diagnosis and treatment rates were also assessed. To this end, patients with the principal diagnosis of low-energy hip, vertebral, or distal radius fractures were recruited for the study. Collected data included risk factors for osteoporosis, history of previous fractures, known history of osteoporosis, and osteoporosis treatment at the time of admission. The patients' prefracture risk profile was also assessed to determine whether osteoporosis could have been identified prior to the index fracture...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29667006/establishment-and-characterization-of-a-c57bl-6-mouse-model-of-bone-metastasis-of-breast-cancer
#9
Toru Hiraga, Tadashi Ninomiya
Bone is one of the most common sites of metastasis in patients with advanced breast cancer; however, the mechanisms of bone metastasis remain to be fully elucidated. Animal models are essential research tools for investigating the mechanisms of diseases and drug actions. To date, there have only been a few reports in which C57BL/6 mice were used for the study of bone metastases of breast cancer. In the current study, we found that intracardiac inoculation of C57BL/6 mouse-derived parental E0771 breast cancer cells (E0771/Pa) frequently lead to bone metastases in C57BL/6 mice within 2 weeks...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29667005/the-bmp-2-mutant-l51p-a-bmp-receptor-ia-binding-deficient-inhibitor-of-noggin
#10
REVIEW
Hany Mohamed Khattab, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Walter Sebald
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineered bone morphogentic protein-2 (BMP-2) variant with a substitution of the 51st leucine with a proline residue. L51P is deficient in BMP receptor binding, but maintains its structure and affinity for inhibitory proteins such as noggin, chordin, and gremlin. These modifications convert the BMP-2 variant L51P into a receptor-inactive inhibitor of BMP antagonists...
April 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29603072/comment-on-effects-of-interventions-with-a-physical-activity-component-on-bone-health-in-obese-children-and-adolescents-a-systematic-review-and-meta-analysis
#11
LETTER
Mohammad Alwardat, Nuha Alwardat
No abstract text is available yet for this article.
March 30, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29603071/serum-homocysteine-levels-are-affected-by-renal-function-during-a-3-year-period-of-minodronate-therapy-in-female-osteoporotic-patients
#12
Tsuyoshi Ohishi, Tomotada Fujita, Daisuke Suzuki, Tatsuya Nishida, Mitsuru Asukai, Yukihiro Matsuyama
Serum homocysteine is a possible marker to indicate bone quality. However, it is not clear whether changes are seen in serum homocysteine levels with long-term bisphosphonate therapy. We aimed to investigate the factors affecting serum homocysteine levels during a 3-year period of monthly minodronate therapy in osteoporotic women, and to examine if the serum homocysteine levels could reflect some aspects of bone metabolism. The study included 43 patients (age 72.3 ± 7.0 years) undergoing treatment for osteoporosis for the first time (New group) and 35 patients (age 74...
March 30, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29603070/high-calcium-phosphate-and-calcitriol-supplementation-leads-to-an-osteocyte-like-phenotype-in-calcified-vessels-and-bone-mineralisation-defect-in-uremic-rats
#13
Sarah-Kim Bisson, Roth-Visal Ung, Sylvain Picard, Danika Valade, Mohsen Agharazii, Richard Larivière, Fabrice Mac-Way
A link between vascular calcification and bone anomalies has been suggested in chronic kidney disease (CKD) patients with low bone turnover disease. We investigated the vascular expression of osteocyte markers in relation to bone microarchitecture and mineralization defects in a model of low bone turnover CKD rats with vascular calcification. CKD with vascular calcification was induced by 5/6 nephrectomy followed by high calcium and phosphate diet, and vitamin D supplementation (Ca/P/VitD). CKD + Ca/P/VitD group (n = 12) was compared to CKD + normal diet (n = 12), control + normal diet (n = 8) and control + Ca/P/VitD supplementation (n = 8)...
March 30, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29536198/gender-differences-in-anti-osteoporosis-drug-treatment-after-osteoporotic-fractures
#14
Youn Jung, Yeonhee Ko, Ha Young Kim, Yong Chan Ha, Young-Kyun Lee, Tae-Young Kim, Dong-Soo Choo, Sunmee Jang
This study examined differences between men and women in factors affecting anti-osteoporosis drug treatment after osteoporotic fracture. Using a national claims database, we analyzed patients aged 50 years and older who experienced their first osteoporotic fracture between January 1, 2008, and December 31, 2012. We examined whether patients were prescribed anti-osteoporosis drugs within 6 months post-fracture. Factors associated with treatment status were identified using multivariate logistic regression...
March 13, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29532248/the-safety-and-effectiveness-profile-of-eldecalcitol-in-a-prospective-post-marketing-observational-study-in-japanese-male-patients-with-osteoporosis
#15
Satoshi Kondo, Hiroyuki Kakihata, Yosuke Nishida, Yuko Furuno, Yumiko Kobayashi, Hidehiro Tabata, Makoto Nomura
We conducted a post-marketing observational study to investigate the safety and effectiveness of eldecalcitol for the treatment of osteoporosis in a Japanese clinical setting. The observation period was 12 months for women and 36 months for men. The final results for the female patients have already been published. In this article, the final results for the male patients are reported. A total of 470 male osteoporosis patients were enrolled. The safety analysis set included 431 patients (mean age, 76.8 years; mean ± SD follow-up period, 631...
March 12, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29523963/changes-in-quality-of-life-in-patients-with-postmenopausal-osteoporosis-receiving-weekly-bisphosphonate-treatment-a-2-year-multicenter-study-in-japan
#16
Hiroshi Hagino, Satoshi Soen, Toshitsugu Sugimoto, Naoto Endo, Ryo Okazaki, Kiyoshi Tanaka, Toshitaka Nakamura
We investigated changes in quality of life (QOL), including pain, in Japanese women aged ≥ 55 years who were diagnosed as having osteoporosis at 265 centers across Japan and treated continuously with once-weekly bisphosphonates for 24 months. In 2650 evaluable patients, a significant improvement in QOL was observed from 3 months after enrollment onward and maintained throughout the 2-year observation period. A significant improvement in scores was observed for all domains of the Euro QOL 5 Dimension (EQ-5D), and the "pain", "health perception", and "posture, figure" domains of the Japanese Osteoporosis QOL Questionnaire (JOQOL)...
March 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29520508/disease-burden-of-fractures-among-patients-with-osteoporosis-in-japan-health-related-quality-of-life-work-productivity-and-activity-impairment-healthcare-resource-utilization-and-economic-costs
#17
Saeko Fujiwara, Xiahong Zhao, Cheryl Teoh, Dena H Jaffe, Yurie Taguchi
Osteoporosis remains undertreated in Japan, and bone fractures are the most frequent complications imposing heavy burden on individuals and the community. This paper investigates the clinical and economic burden of fractures among osteoporosis patients in Japan. The Japan National Health and Wellness Survey 2012-2014 database was used for analysis. Respondents aged ≥ 50 years and indicated a physician diagnosis of osteoporosis (N = 1107) were categorized into three subgroups: no prior fracture (N = 693), single fracture (N = 242), and multiple (≥ 2) fractures (N = 172)...
March 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29520507/pcos-and-risk-of-fractures
#18
LETTER
Yueh-Han Hsu, Hsin-Yi Yang
No abstract text is available yet for this article.
March 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29520506/effects-of-denosumab-on-bone-mineral-density-in-japanese-women-with-osteoporosis-treated-with-aromatase-inhibitors-for-breast-cancer
#19
Katsuhiko Nakatsukasa, Hiroshi Koyama, Yoshimi Ouchi, Kouichi Sakaguchi, Yoshifumi Fujita, Takayuki Matsuda, Makoto Kato, Eiichi Konishi, Tetsuya Taguchi
Adjuvant aromatase inhibitor (AI) therapy, for hormone receptor-positive breast cancer, in postmenopausal women is associated with bone loss, leading to an increased risk of fractures. Denosumab, an antibody raised against the receptor activator of nuclear factor-κB ligand, has been proven to protect against AI-induced bone loss. Hence, we aimed to determine whether denosumab is effective in postmenopausal Japanese women with osteoporosis, treated with AI. We prospectively evaluated the bone mineral density (BMD) in the lumbar spine and the bilateral femoral neck in 102 postmenopausal women with clinical hormone receptor-positive breast cancer, stages I-IIIA, during a postoperative period of 12 months...
March 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28642975/association-of-bone-metabolism-markers-with-coronary-atherosclerosis-and-coronary-artery-disease-in-postmenopausal-women
#20
Yan Ling, Zhen Wang, Bingjie Wu, Xin Gao
This study aimed to evaluate the association of bone metabolism markers with coronary atherosclerosis and coronary artery disease (CAD) in postmenopausal women. Based on the findings of coronary angiography, 111 women with CAD and 116 women without CAD were recruited. Serum calcium, phosphate, parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), osteocalcin, N-terminal propeptide of type I procollagen (P1NP) and C-terminal cross-linked telopeptide of type I collagen (CTX) were measured. The Gensini score was used to assess the severity of coronary atherosclerosis...
May 2018: Journal of Bone and Mineral Metabolism
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