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Journal of Bone and Mineral Metabolism

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https://www.readbyqxmd.com/read/30191458/the-relationships-between-bone-variables-and-physical-fitness-across-the-bmi-spectrum-in-young-adult-women
#1
Nathalie Al Rassy, Ziad Bakouny, Joseph Matta, Fabienne Frenn, Ghassan Maalouf, Maroun Rizkallah, Falah Bachour, Amer Sebaaly, Pierre Hardouin, Christophe Chauveau, Rawad El Hage
In this cross-sectional study we aimed to evaluate the relationship between physical fitness and bone variables across the body mass index (BMI) spectrum in women aged 20-35 years. The study included 13 underweight women (BMI < 18.5 kg/m2 ), 24 normal weight women (BMI 18.5-24.9 kg/m2 ), and 20 overweight/obese women (BMI ≥ 25 kg/m2 ) aged between 20 and 35 years. Bone mineral density (BMD) and content (BMC) at the whole body, lumbar spine, and femoral neck, lumbar spine trabecular bone score, femoral neck geometry were assessed using dual-energy X-ray absorptiometry...
September 6, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30191457/bone-mineral-density-loss-in-ambulatory-children-with-epilepsy-in-spite-of-using-supplemental-vitamin-d-in-southern-iran-a-case-control-study
#2
Soroor Inaloo, Mohammad Paktinat, Forough Saki, Pegah Katibeh, Hamid Nemati, Mohammad Hossein Dabbaghmanesh, Gholam Hossein Ranjbar Omrani
Epilepsy might have adverse effect on bone density due to underlying disease, drugs, vitamin D deficiency, immobilization and malnutrition. We investigated the bone mineral density in ambulatory vitamin-D supplemented children with epilepsy. This case-control study was conducted on 90 epileptic children aged 11.4 ± 3.3 years, and age and gender matched controls in pediatric neurology clinics of Shiraz, in Southern Iran, 2016. Anthropometric measurements, puberty, sun exposure, physical activity and biochemical variables were assessed...
September 6, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30191456/osteoporosis-and-vertebral-fracture-are-associated-with-deterioration-of-activities-of-daily-living-and-quality-of-life-in-patients-with-type-2-diabetes-mellitus
#3
Ippei Kanazawa, Ayumu Takeno, Ken-Ichiro Tanaka, Yuko Yamane, Toshitsugu Sugimoto
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture. However, whether diabetes-related osteoporosis independently contributes to the deterioration of activities of daily living (ADLs) and quality of life (QOL) is unclear. This cross-sectional study investigated the association between osteoporosis, ADLs, and QOL in 309 patients with T2DM. ADLs and QOL were assessed using Barthel Index (BI) and a SF-36 questionnaire. Multiple logistic regression analyses adjusted for age, gender, T2DM duration, body mass index, hemoglobin A1c, estimated GFR, diabetic neuropathy, retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, peripheral artery disease, and anti-diabetic treatments were conducted...
September 6, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187277/umbilical-cord-mesenchymal-stem-cell-conditioned-medium-restored-the-expression-of-collagen-ii-and-aggrecan-in-nucleus-pulposus-mesenchymal-stem-cells-exposed-to-high-glucose
#4
Lei Qi, Ran Wang, Qing Shi, Ming Yuan, Min Jin, Dong Li
Diabetes can cause intervertebral disc degeneration by accelerating apoptosis and senescence of nucleus pulposus mesenchymal stem cells (NPMSCs). The aim of this study was to determine the effect of umbilical cord mesenchymal stem cells (UCMSCs) conditioned medium on high glucose (HG) induced degradation of NPMSCs produced extracellular matrix. NPMSCs were isolated from the inner intervertebral disc tissue using type XI collagenase digestion. According to Annexin V/propidium iodide (PI) flow cytometry analysis; HG leads to an increase in the rate of NPMSCs apoptosis...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187276/fgf2-responsive-genes-in-human-dental-pulp-cells-assessed-using-a-rat-spinal-cord-injury-model
#5
Ken Sugiyama, Kosuke Nagashima, Takahiro Miwa, Yuta Shimizu, Tomoko Kawaguchi, Kazuki Iida, Naritaka Tamaoki, Daijiro Hatakeyama, Hitomi Aoki, Chikara Abe, Hironobu Morita, Takahiro Kunisada, Toshiyuki Shibata, Hidefumi Fukumitsu, Ken-Ichi Tezuka
The central nervous system in adult mammals does not heal spontaneously after spinal cord injury (SCI). However, SCI treatment has been improved recently following the development of cell transplantation therapy. We recently reported that fibroblast growth factor (FGF) 2-pretreated human dental pulp cells (hDPCs) can improve recovery in a rat model of SCI. This study aimed to investigate mechanisms underlying the curative effect of SCI enhanced via FGF2 pretreatment; we selected three hDPC lines upon screening for the presence of mesenchymal stem cell markers and of their functionality in a rat model of SCI, as assessed using the Basso, Beattie, and Bresnahan score of locomotor functional scale, electrophysiological tests, and morphological analyses...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187275/development-of-scoliosis-in-young-children-with-osteogenesis-imperfecta-undergoing-intravenous-bisphosphonate-therapy
#6
Masafumi Kashii, Sadaaki Kanayama, Taichi Kitaoka, Takahiro Makino, Takashi Kaito, Motoki Iwasaki, Takuo Kubota, Takehisa Yamamoto, Keiichi Ozono, Hideki Yoshikawa
The purpose of this study was to clarify the prevalence of scoliosis and determine risk factors for the development of scoliosis in young children with osteogenesis imperfecta (OI) who underwent intravenous pamidronate (PAM) therapy. Thirty-four young children with OI who had no scoliosis at the first PAM administration underwent cyclic PAM therapy alone. The medical records and radiographs of these patients were retrospectively reviewed. We examined the relationship between scoliosis (Cobb angle ≥ 10) and type of OI (Sillence classification: types I, III, and IV), physical mobility, Z-scores of bone mineral density in L2-4 of the lumbar spine (L2-4 BMD Z-scores), age of patients at first treatment with PAM, pelvic frontal tilt and leg-length discrepancy...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187274/bone-marrow-lesion-is-associated-with-disability-for-activities-of-daily-living-in-patients-with-early-stage-knee-osteoarthritis
#7
Ryo Sadatsuki, Muneaki Ishijima, Haruka Kaneko, Lizu Liu, Ippei Futami, Shinnosuke Hada, Mayuko Kinoshita, Mitsuaki Kubota, Takako Aoki, Yuji Takazawa, Hiroshi Ikeda, Yasunori Okada, Kazuo Kaneko
Osteoarthritis of the knee (knee OA) induces pain, loss of mobility and diminished activities of daily living (ADL). Although an understanding of the pathophysiology of early stage knee OA has been developed, the structural changes associated with disability for ADL in early stage knee OA are still unclear. The aim of the present study was to examine magnetic resonance imaging (MRI)-detected changes associated with disability for ADL in patients with early stage knee OA. One hundred and thirty-two patients with early stage medial knee OA (Kellgren-Lawrence grade ≤ 2) who first visited the outpatient clinic at our university hospital were included...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187273/denosumab-is-effective-toward-glucocorticoid-induced-osteoporosis-patients-complicated-with-rheumatic-diseases-regardless-of-prior-anti-osteoporotic-drugs
#8
Naoki Iwamoto, Momoko Okamoto, Sosuke Tsuji, Yushiro Endo, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Remi Sumiyoshi, Takashi Igawa, Tomohiro Koga, Shin-Ya Kawashiri, Toshiyuki Aramaki, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Katsumi Eguchi, Yukitaka Ueki, Atsushi Kawakami
We examined the efficacy and safety of denosumab as treatment for glucocorticoid-induced osteoporosis (GIOP) patients complicated with rheumatic diseases, by measuring patients' lumber bone mineral density (BMD) and bone turnover markers. A total of 66 consecutive patients for whom denosumab was initiated between July 2013 and August 2016 were enrolled and evaluated for 12 months. All of the patients were treated with glucocorticoids for underlying rheumatic diseases. The clinical assessment included measurements of the BMD of the lumbar spine (L2-L4) by a dual-energy X-ray absorptiometry technique and the bone turnover markers N-terminal telopeptide of type 1 collagen (NTX) in urine, serum intact procollagen type 1 N-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) at baseline, 6 months and 12 months after the start of denosumab treatment...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30187272/effect-of-a-6-week-supervised-detraining-period-on-bone-metabolism-markers-and-their-association-with-ergometrics-and-components-of-the-hypothalamic-pituitary-gonadal-hpg-axis-in-professional-male-soccer-players
#9
Nikolaos E Koundourakis, Nikolaos Androulakis, Eirini Dermitzaki, Maria Venihaki, Andrew N Margioris
The aim of this study was to examine the effect of a supervised 6-week detraining period on bone metabolism markers, and their association with ergometrics, and components of the hypothalamic-pituitary-gonadal (HPG) axis in elite male professional soccer players. Sixty-seven soccer players (mean age ± SD 23.4 ± 5.2 years) that were following a supervised training program participated in this study. Players were tested twice: immediately after the conclusion of the competition period, and following the detraining period, for the determination of bone-turnover rates, ergometrics, and components of the HPG-axis...
September 5, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30097709/1-25-dihydroxyvitamin-d3-attenuates-disease-severity-and-induces-synoviocyte-apoptosis-in-a-concentration-dependent-manner-in-rats-with-adjuvant-induced-arthritis-by-inactivating-the-nf-%C3%AE%C2%BAb-signaling-pathway
#10
Hua-Qiang Sun, Dong Yan, Qin-Nan Wang, Hong-Zheng Meng, Ye-Yong Zhang, Lu-Xu Yin, Xin-Feng Yan, Shu-Feng Li
An aggressive proliferation of synoviocytes is the hallmark of rheumatoid arthritis (RA). Emerging evidence shows that inhibiting the NF-κB signaling pathway with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] may be a therapeutic approach for controlling inflammatory diseases. In this study, we demonstrated the protective effects of three different 1,25(OH)2D3 concentration on adjuvant-induced arthritis (AA) rats through the NF-κB signaling pathway and their pro-apoptotic roles in cultured adjuvant-induced arthritis synoviocytes (AIASs)...
August 10, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30094509/peg10-counteracts-signaling-pathways-of-tgf-%C3%AE-and-bmp-to-regulate-growth-motility-and-invasion-of-sw1353-chondrosarcoma-cells
#11
Yuhei Yahiro, Shingo Maeda, Naohiro Shinohara, Go Jokoji, Daisuke Sakuma, Takao Setoguchi, Yasuhiro Ishidou, Satoshi Nagano, Setsuro Komiya, Noboru Taniguchi
Recently, we reported highly active transforming growth factor (TGF)-β and bone morphogenetic protein (BMP) signaling in human chondrosarcoma samples and concurrent downregulation of paternally expressed gene 10 (PEG10). PEG10 expression was suppressed by TGF-β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. However, the roles of PEG10 in bone tumors, including chondrosarcoma, remain unknown. Here, we report that PEG10 promotes SW1353 chondrosarcoma cell growth by preventing TGF-β1-mediated suppression...
August 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30066165/microcrack-associated-bone-remodeling-is-rarely-observed-in-biopsies-from-athletes-with-medial-tibial-stress-syndrome
#12
Marinus Winters, David B Burr, Henk van der Hoeven, Keith W Condon, Johan Bellemans, Maarten H Moen
The pathology of medial tibial stress syndrome (MTSS) is unknown. Studies suggest that MTSS is a bony overload injury, but histological evidence is sparse. The presence of microdamage, and its potential association with targeted remodeling, could provide evidence for the pathogenesis of MTSS. Understanding the pathology underlying MTSS could contribute to effective preventative and therapeutic interventions for MTSS. Our aim was to retrospectively evaluate biopsies, previously taken from the painful area in athletes with MTSS, for the presence of linear microcracks, diffuse microdamage and remodeling...
July 31, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30062431/finite-element-analysis-of-the-mouse-proximal-ulna-in-response-to-elbow-loading
#13
Feifei Jiang, Aydin Jalali, Chie Deguchi, Andy Chen, Shengzhi Liu, Rika Kondo, Kazumasa Minami, Takashi Horiuchi, Bai-Yan Li, Alexander G Robling, Jie Chen, Hiroki Yokota
Bone is a mechano-sensitive tissue that alters its structure and properties in response to mechanical loading. We have previously shown that application of lateral dynamic loads to a synovial joint, such as the knee and elbow, suppresses degradation of cartilage and prevents bone loss in arthritis and postmenopausal mouse models, respectively. While loading effects on pathophysiology have been reported, mechanical effects on the loaded joint are not fully understood. Because the direction of joint loading is non-axial, not commonly observed in daily activities, strain distributions in the laterally loaded joint are of great interest...
July 30, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30032440/metformin-protects-bone-mass-in-ultra-high-molecular-weight-polyethylene-particle-induced-osteolysis-by-regulating-osteocyte-secretion
#14
Zhao Yan, Shu Zhu, Xiaoxi Tian, Zichen Ye, Dongsheng Zhai, Zheng Zhu, Di Wei, Qingsheng Zhu, Zifan Lu, Xiaorui Cao
Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bone formation sclerostin (SOST) and Dickkopf-related protein 1 (DKK1), and increased osteoprotegerin (OPG) secretion and the ratio of OPG/Receptor Activator for Nuclear Factor-κB Ligand (RANKL)...
July 21, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30019249/study-design-of-multi-center-open-label-randomized-controlled-head-to-head-trial-comparing-minodronic-acid-and-raloxifene-japanese-osteoporosis-intervention-trial-joint-04
#15
Yukari Uemura, Shiro Tanaka, Teruhiko Miyazaki, Mayumi Tsukiyama, Teruki Sone, Akira Taguchi, Satoshi Soen, Satoshi Mori, Hiroshi Hagino, Toshitsugu Sugimoto, Masao Fukunaga, Hiroaki Ohta, Toshitaka Nakamura, Hajime Orimo, Masataka Shiraki
We planned to conduct multi-center, open-labeled, blinded-endpoints, head-to-head randomized trial of minodronate and raloxifene to compare incidences of vertebral and non-vertebral fractures. The study is the Japanese Osteoporosis Intervention Trial protocol number 4 (JOINT-4). Here, we present the pre-fixed study design. The inclusion criteria are ambulatory older women with osteoporosis, aged > 60 years, and without pre-specified risk factors for secondary osteoporosis and dementia. The subjects who meet selection criteria will be randomly allocated to the raloxifene (60 mg/day) or minodronate (1 mg/day or 50 mg/4 weeks) groups using the central registry...
July 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30019248/microrna-92a-1-5p-influences-osteogenic-differentiation-of-mc3t3-e1-cells-by-regulating-%C3%AE-catenin
#16
Zhiping Lin, Yangyang Tang, Hongchang Tan, Daozhang Cai
Osteoblastic differentiation is a complex process that is critical for proper bone formation. An increasing number of studies have suggested that microRNAs (miRNAs) are pivotal regulators in various physiological and pathological processes, including osteogenesis. Here, we discuss the influence of miRNA-92a-1-5p on osteogenic differentiation. We found that miR-92a-1-5p was obviously downregulated during osteogenic differentiation of MC3T3-E1 cells. Gain-of-function and loss-of-function experiments revealed that miR-92a-1-5p was a negative regulator of osteogenic differentiation...
July 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30014298/impact-of-vitamin-c-on-teriparatide-treatment-in-the-improvement-of-bone-mineral-density-strength-and-quality-in-vitamin-c-deficient-rats
#17
Naohisa Miyakoshi, Masashi Fujii, Yuji Kasukawa, Yoichi Shimada
Age-related decreases in serum levels of vitamin C (VC) may negatively affect the efficacy of anti-osteoporotic pharmacotherapy. The purpose of this study was to evaluate the effects of VC and teriparatide (TPTD) on bone mineral density (BMD), strength, and quality in VC-deficient osteogenic disorder Shionogi (ODS) rats. Six-month-old female ODS rats were divided into an untreated ODS control group, a VC group, a TPTD group, and a VC + TPTD group, based on the administration of VC and TPTD (n = 10 each)...
July 16, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/30014297/accumulation-of-microdamage-at-complete-and-incomplete-fracture-sites-in-a-patient-with-bilateral-atypical-femoral-fractures-on-glucocorticoid-and-bisphosphonate-therapy
#18
Ken Iwata, Tasuku Mashiba, Satoshi Mori, Tetsuji Yamamoto
No abstract text is available yet for this article.
July 16, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29956021/factors-associated-with-low-trabecular-bone-scores-in-patients-with-end-stage-kidney-disease
#19
Hye Eun Yoon, Yaeni Kim, Seok Joon Shin, Yeon Sik Hong, Kwi Young Kang
The trabecular bone score (TBS) is a textural index that indirectly assesses bone trabecular microarchitecture using lumbar spine images obtained by dual-energy X-ray absorptiometry (DXA). This study compared the TBS of patients with end-stage kidney disease (ESKD) with that of matched controls to identify risk factors associated with a low TBS. TBS and bone mineral density (BMD) were assessed in ESKD patients (n = 76) and age- and sex-matched control subjects (n = 76) using DXA. The TBS of both groups was then compared, and risk factors associated with a low TBS (defined as ≤ 1...
June 28, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29956020/incidence-of-four-major-types-of-osteoporotic-fragility-fractures-among-elderly-individuals-in-sado-japan-in-2015
#20
Norio Imai, Naoto Endo, Yugo Shobugawa, Takeo Oinuma, Yasuhito Takahashi, Kazuaki Suzuki, Yuya Ishikawa, Tatsuo Makino, Hayato Suzuki, Dai Miyasaka, Mayumi Sakuma
The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2015. The incidence of vertebral (p < 0.001) and radius fractures (p = 0.001) was lower in 2015 than in 2010, with only the incidence of hip fracture (p = 0.013) being lower in 2015 than in 2004...
June 28, 2018: Journal of Bone and Mineral Metabolism
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