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Journal of Bone and Mineral Metabolism

Ziyi Wang, Yoshihito Ishihara, Takanori Ishikawa, Mitsuhiro Hoshijima, Naoya Odagaki, Ei Ei Hsu Hlaing, Hiroshi Kamioka
This study aimed to predict the key genes and pathways that are activated when different types of mechanical loading are applied to osteocytes. mRNA expression datasets (series number of GSE62128 and GSE42874) were obtained from Gene Expression Omnibus database (GEO). High gravity-treated osteocytic MLO-Y4 cell-line samples from GSE62128 (Set1), and fluid flow-treated MLO-Y4 samples from GSE42874 (Set2) were employed. After identifying the differentially expressed genes (DEGs), functional enrichment was performed...
November 9, 2018: Journal of Bone and Mineral Metabolism
Forough Saki, Seyed Reza Kasaee, Faezeh Sadeghian, Pedram Talezadeh, Gholam Hossein Ranjbar Omrani
Testosterone is an essential hormone to maintain bone integrity; however, the effect of aromatase enzyme in androgen-induced bone maintenance remains somewhat unclear. The present study evaluated the effect of testosterone itself and combined with letrozole, an aromatase inhibitor, on bone mineral density of male rats. Total of 48 male rats were divided into 4 equal groups (n = 12/group); sham group, O: orchiectomy, O + T: orchiectomized rats treated with testosterone, O + T + L: orchiectomized rats treated with combination of testosterone and letrozole...
November 3, 2018: Journal of Bone and Mineral Metabolism
Ryan D Ross, Matthew J Meagher, D Rick Sumner
Dietary calcium (Ca) restriction during lactation in the rat, which induces intra-cortical and endocortical remodeling, has been proposed as a model to study bone matrix maturation in the adult skeleton. The purpose of this study was to assess the effects of dietary Ca restriction during lactation on post-weaning mineral metabolism and bone formation. Mated female Sprague-Dawley rats were randomized into groups receiving either 0.6% Ca (lactation/normal Ca) or 0.01% Ca (lactation/low Ca) diets during lactation...
October 25, 2018: Journal of Bone and Mineral Metabolism
Gustavo Ribeiro Oliveira, Paula Katherine Vargas-Sanchez, Roger Rodrigo Fernandes, Milla Sprone Tavares Ricoldi, Mayara Sgarbi Semeghini, Dimitrius Leonardo Pitol, Luiz Gustavo de Sousa, Selma Siessere, Karina Fittipaldi Bombonato-Prado
Antioxidant properties of several nutrients may influence bone metabolism, affording protection against damaging effects caused by oxidative stress. Thus, we hypothesized that lycopene may benefit bone tissue metabolism and functional activity of osteoblastic cells from bone marrow of osteoporotic female rats. Wistar rats were ovariectomized and paired with sham animals. In vitro evaluations were performed after 60 days of surgery, when cells were cultured in osteogenic medium and divided in control (C), ovariectomized (OVX) and ovariectomized + 1 μmol/L lycopene (OVXL) groups...
October 24, 2018: Journal of Bone and Mineral Metabolism
Hiroyuki Yamada, Yasuo Ochi, Hiroshi Mori, Satoshi Nishikawa, Yasuaki Hashimoto, Makoto Tanaka, Steve Deacon, Kazuhito Kawabata
This study evaluated the long-term effects of the cathepsin K inhibitor ONO-5334 on bone mass and strength in ovariectomised (OVX) cynomolgus monkeys. Animals were assigned to one of the following six groups: Sham (non-OVX), OVX control treated with vehicle, ONO-5334 1.2, 6 or 30 mg/kg/day, p.o., or alendronate (ALN) 0.05 mg/kg/2 weeks, i.v. for 16 months. Peripheral quantitative computed tomography (pQCT) analysis revealed that ONO-5334 increased not only trabecular bone mineral density (BMD) but also cortical BMD in the distal radius and the lumbar vertebra...
October 24, 2018: Journal of Bone and Mineral Metabolism
Masanori Koide, Yasuhiro Kobayashi
Osteocytes are embedded in bone matrices and are connected to each other to respond to mechanical loading on bone. Recent studies have demonstrated the roles of mechanical loading in bone accrual. Bone responds to mechanical loading by decreasing the expression of sclerostin, an inhibitor of Wnt/β-catenin signals, in osteocytes. This increases bone mass because the activation of Wnt/β-catenin signals in bone microenvironments promotes bone formation and suppresses bone resorption. Thus, in recent years, sclerostin have attracted increasing attention in bone metabolism...
October 24, 2018: Journal of Bone and Mineral Metabolism
Satoshi Nakamura, Yuiko Sato, Tami Kobayashi, Takatsugu Oike, Yosuke Kaneko, Kana Miyamoto, Atsushi Funayama, Akihito Oya, Toru Nishiwaki, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Insulin-like growth factor-I (IGF-I) is a peptide with diverse functions, among them regulation of embryonic development and bone homeostasis. Serum IGF-I levels decline in the elderly; however, IGF-I function in adults has not been clearly defined. Here, we show that IGF-I is required to maintain muscle mass in adults. We crossed Igf-I flox'd and Mx1 Cre mice to yield Mx1 Cre/Igf-Iflox/flox (IGF-I cKO) mice, and deleted Igf-I in adult mice by polyIpolyC injection. We demonstrate that, although serum IGF-I levels significantly decreased after polyIpolyC injection relative to (Igf-Iflox/flox ) controls, serum glucose levels were unchanged...
October 15, 2018: Journal of Bone and Mineral Metabolism
Yoshiya Tanaka
The immune system and bone metabolism influence each other. An imbalance in the immune system, resulting in inflammatory stimuli may induce an imbalance in bone turnover via induction of osteoclast differentiation and inhibition of osteoblast differentiation, leading to various pathological conditions including osteoporosis. T-cell subsets, helper T (Th)1 and Th17, which activate the immune system, induce osteoclasts, whereas regulatory T (Treg) cells, responsible for immunosuppression, inhibit osteoclastic differentiation...
October 15, 2018: Journal of Bone and Mineral Metabolism
Ana Maria Sper Simão, Maytê Bolean, Bruno Zoccaratto Favarin, Ekeveliny Amabile Veschi, Camila Bussola Tovani, Ana Paula Ramos, Massimo Bottini, Rene Buchet, José Luis Millán, Pietro Ciancaglini
Tissue-nonspecific alkaline phosphatase (TNAP), a glycosylphosphatidylinositol-anchored ectoenzyme present on the membrane of matrix vesicles (MVs), hydrolyzes the mineralization inhibitor inorganic pyrophosphate as well as ATP to generate the inorganic phosphate needed for apatite formation. Herein, we used proteoliposomes harboring TNAP as MV biomimetics with or without nucleators of mineral formation (amorphous calcium phosphate and complexes with phosphatidylserine) to assess the role of the MVs' membrane lipid composition on TNAP activity by means of turbidity assay and FTIR analysis...
October 15, 2018: Journal of Bone and Mineral Metabolism
Malachi J McKenna, Julie Martin-Grace, Rachel Crowley, Patrick J Twomey, Mark T Kilbane
Congenital hypophosphataemia (CH) is a collection of disorders that cause defective bone mineralisation manifesting with rickets in childhood and osteomalacia in adulthood. Bone turnover markers (BTMs) are surrogate measures of metabolic bone disease severity. We explored the utility of BTMs in 27 adults with CH: 23 had X-linked hypophosphataemia (XLH), of whom 2 were hypoparathyroid post-total parathyroidectomy (PTx); 2 had autosomal dominant hypophosphataemic rickets (ADHR), and 2 had none of the known mutations...
September 20, 2018: Journal of Bone and Mineral Metabolism
Ippei Kanazawa, Masakazu Notsu, Ayumu Takeno, Ken-Ichiro Tanaka, Toshitsugu Sugimoto
The aim of this cross-sectional study was to examine the association between body mass index (BMI) and the prevalence of vertebral fracture (VF) in Japanese patients with type 2 diabetes (T2DM). A total of 798 patients with T2DM were enrolled. VF was determined semi-quantitatively using lateral X-ray films. The association between BMI quartiles (Q1: ≤ 21.2 kg/m2 , Q2: 21.3-23.4 kg/m2 , Q3: 23.5-25.8 kg/m2 , Q4: 25.9≤ kg/m2 ) and the presence of VF was examined. Multiple logistic regression analyses adjusted for age, sex, diabetes duration, hemoglobin A1c (HbA1c), estimated glomerular filtration rate, and albumin showed that Q1, Q3, and Q4 were significantly associated with an increased VF risk compared to Q2, which served as a reference [Q1; odds ratio (OR) = 1...
September 20, 2018: Journal of Bone and Mineral Metabolism
Seung Hun Lee, Mi Kyung Kwak, Seong Hee Ahn, Hyeonmok Kim, Yoon Young Cho, Sunghwan Suh, Kee-Ho Song, Jung-Min Koh, Jae Hyeon Kim, Beom-Jun Kim
The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary metanephrine (UM), and urinary normetanephrine (UNM) were measured in 16 patients with pheochromocytoma and 224 patients with nonfunctioning adrenal incidentaloma (NFAI), we compared skeletal muscle mass and fat mass (FM) between the two groups...
September 20, 2018: Journal of Bone and Mineral Metabolism
Fei Jiang, Xiaohan Yang, Xin Meng, Zhixuan Zhou, Ning Chen
CBX7 is shown to down-regulate the expression of osteopontin (OPN) that is associated with osteoblast function. Here, we studied the role of CBX7 in the wound healing of tooth extraction socket in which osteoblast activity is critical via comparison between CBX7-knockout (CBX7-/- ) mice and their wild-type (WT) counterparts of 6 weeks old with maxillary first molar extracted. Mice were euthanized at 7, 14, and 21 days after extractions, and alveolar sockets were assessed by semi-quantitative histomorphometry for hard tissue healing, including new bone fill (Masson's trichrome staining), osteoblast activity (OPN/osterix, Osx), osteoclast activity (tartrate-resistant acid phosphatase, TRAP), and for soft tissue healing, including blood vessels (alpha smooth muscle actin, α-SMA)...
September 20, 2018: Journal of Bone and Mineral Metabolism
Dong Won Byun, Seong-Hwan Moon, Tak Kim, Hae-Hyeog Lee, Hyoung Moo Park, Moo-Il Kang, Yong-Chan Ha, Ho-Yeon Chung, Byung-Koo Yoon, Tae-Young Kim, Soo Uk Chae, Chan Soo Shin, Kyu-Hyun Yang, Jae Hyup Lee, Jae Suk Chang, Sung Hoon Kim, In Joo Kim, Jung-Min Koh, Jung Hwa Jung, Kyong Wook Yi, Jeong Joon Yoo, Dong Jin Chung, Young-Kyun Lee, Hyun-Koo Yoon, Seongbin Hong, Deog-Yoon Kim, Ki Hyun Baek, Hyun-Joo Kim, Young-Joo Kim, Seongsik Kang, Yong-Ki Min
Patient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected...
September 20, 2018: Journal of Bone and Mineral Metabolism
Nathalie Al Rassy, Ziad Bakouny, Joseph Matta, Fabienne Frenn, Ghassan Maalouf, Maroun Rizkallah, Falah Bachour, Amer Sebaaly, Pierre Hardouin, Christophe Chauveau, Rawad El Hage
In this cross-sectional study we aimed to evaluate the relationship between physical fitness and bone variables across the body mass index (BMI) spectrum in women aged 20-35 years. The study included 13 underweight women (BMI < 18.5 kg/m2 ), 24 normal weight women (BMI 18.5-24.9 kg/m2 ), and 20 overweight/obese women (BMI ≥ 25 kg/m2 ) aged between 20 and 35 years. Bone mineral density (BMD) and content (BMC) at the whole body, lumbar spine, and femoral neck, lumbar spine trabecular bone score, femoral neck geometry were assessed using dual-energy X-ray absorptiometry...
September 6, 2018: Journal of Bone and Mineral Metabolism
Soroor Inaloo, Mohammad Paktinat, Forough Saki, Pegah Katibeh, Hamid Nemati, Mohammad Hossein Dabbaghmanesh, Gholam Hossein Ranjbar Omrani
Epilepsy might have adverse effect on bone density due to underlying disease, drugs, vitamin D deficiency, immobilization and malnutrition. We investigated the bone mineral density in ambulatory vitamin-D supplemented children with epilepsy. This case-control study was conducted on 90 epileptic children aged 11.4 ± 3.3 years, and age and gender matched controls in pediatric neurology clinics of Shiraz, in Southern Iran, 2016. Anthropometric measurements, puberty, sun exposure, physical activity and biochemical variables were assessed...
September 6, 2018: Journal of Bone and Mineral Metabolism
Ippei Kanazawa, Ayumu Takeno, Ken-Ichiro Tanaka, Yuko Yamane, Toshitsugu Sugimoto
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture. However, whether diabetes-related osteoporosis independently contributes to the deterioration of activities of daily living (ADLs) and quality of life (QOL) is unclear. This cross-sectional study investigated the association between osteoporosis, ADLs, and QOL in 309 patients with T2DM. ADLs and QOL were assessed using Barthel Index (BI) and a SF-36 questionnaire. Multiple logistic regression analyses adjusted for age, gender, T2DM duration, body mass index, hemoglobin A1c, estimated GFR, diabetic neuropathy, retinopathy, nephropathy, cardiovascular disease, cerebrovascular disease, peripheral artery disease, and anti-diabetic treatments were conducted...
September 6, 2018: Journal of Bone and Mineral Metabolism
Lei Qi, Ran Wang, Qing Shi, Ming Yuan, Min Jin, Dong Li
Diabetes can cause intervertebral disc degeneration by accelerating apoptosis and senescence of nucleus pulposus mesenchymal stem cells (NPMSCs). The aim of this study was to determine the effect of umbilical cord mesenchymal stem cells (UCMSCs) conditioned medium on high glucose (HG) induced degradation of NPMSCs produced extracellular matrix. NPMSCs were isolated from the inner intervertebral disc tissue using type XI collagenase digestion. According to Annexin V/propidium iodide (PI) flow cytometry analysis; HG leads to an increase in the rate of NPMSCs apoptosis...
September 5, 2018: Journal of Bone and Mineral Metabolism
Ken Sugiyama, Kosuke Nagashima, Takahiro Miwa, Yuta Shimizu, Tomoko Kawaguchi, Kazuki Iida, Naritaka Tamaoki, Daijiro Hatakeyama, Hitomi Aoki, Chikara Abe, Hironobu Morita, Takahiro Kunisada, Toshiyuki Shibata, Hidefumi Fukumitsu, Ken-Ichi Tezuka
The central nervous system in adult mammals does not heal spontaneously after spinal cord injury (SCI). However, SCI treatment has been improved recently following the development of cell transplantation therapy. We recently reported that fibroblast growth factor (FGF) 2-pretreated human dental pulp cells (hDPCs) can improve recovery in a rat model of SCI. This study aimed to investigate mechanisms underlying the curative effect of SCI enhanced via FGF2 pretreatment; we selected three hDPC lines upon screening for the presence of mesenchymal stem cell markers and of their functionality in a rat model of SCI, as assessed using the Basso, Beattie, and Bresnahan score of locomotor functional scale, electrophysiological tests, and morphological analyses...
September 5, 2018: Journal of Bone and Mineral Metabolism
Masafumi Kashii, Sadaaki Kanayama, Taichi Kitaoka, Takahiro Makino, Takashi Kaito, Motoki Iwasaki, Takuo Kubota, Takehisa Yamamoto, Keiichi Ozono, Hideki Yoshikawa
The purpose of this study was to clarify the prevalence of scoliosis and determine risk factors for the development of scoliosis in young children with osteogenesis imperfecta (OI) who underwent intravenous pamidronate (PAM) therapy. Thirty-four young children with OI who had no scoliosis at the first PAM administration underwent cyclic PAM therapy alone. The medical records and radiographs of these patients were retrospectively reviewed. We examined the relationship between scoliosis (Cobb angle ≥ 10) and type of OI (Sillence classification: types I, III, and IV), physical mobility, Z-scores of bone mineral density in L2-4 of the lumbar spine (L2-4 BMD Z-scores), age of patients at first treatment with PAM, pelvic frontal tilt and leg-length discrepancy...
September 5, 2018: Journal of Bone and Mineral Metabolism
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