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Journal of Bone and Mineral Metabolism

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https://www.readbyqxmd.com/read/29335796/association-between-frailty-and-bone-loss-in-patients-undergoing-maintenance-hemodialysis
#1
Kei Yoneki, Jun Kitagawa, Keika Hoshi, Manae Harada, Takaaki Watanabe, Takahiro Shimoda, Ryota Matsuzawa, Atsushi Yoshida, Yusuke Matsunaga, Yasuo Takeuchi, Kentaro Kamiya, Atsuhiko Matsunaga
Frailty is significantly associated with bone loss in the general population. However, it is unclear whether this association also exists in patients undergoing hemodialysis who have chronic kidney disease-mineral and bone disorder (CKD-MBD). This study aimed to assess the association between frailty and bone loss in patients undergoing hemodialysis. This cross-sectional study included 214 (90 women, 124 men) Japanese outpatients undergoing maintenance hemodialysis three times per week, with a mean age of 67...
January 15, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29332195/histomorphometry-and-cortical-robusticity-of-the-adult-human-femur
#2
Justyna Jolanta Miszkiewicz, Patrick Mahoney
Recent quantitative analyses of human bone microanatomy, as well as theoretical models that propose bone microstructure and gross anatomical associations, have started to reveal insights into biological links that may facilitate remodeling processes. However, relationships between bone size and the underlying cortical bone histology remain largely unexplored. The goal of this study is to determine the extent to which static indicators of bone remodeling and vascularity, measured using histomorphometric techniques, relate to femoral midshaft cortical width and robusticity...
January 13, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29327303/differential-osteopontin-expression-in-human-osteoblasts-derived-from-iliac-crest-and-alveolar-bone-and-its-role-in-early-stages-of-angiogenesis
#3
Martin Wein, Diana Huelter-Hassler, Katja Nelson, Tobias Fretwurst, Susanne Nahles, Guenter Finkenzeller, Brigitte Altmann, Thorsten Steinberg
In our previous study, we revealed significant differences of osteopontin (OPN) gene expression in primary human osteoblasts (HOBs) derived from iliac crest bone (iHOBs) and alveolar bone (aHOBs). The present study aims at assigning this discriminative expression to a possible biologic function. OPN is known to be involved in several pathologic and physiologic processes, among others angiogenesis. Therefore, we studied the reaction of human umbilical vein endothelial cells (HUVECs) to HOB-derived OPN regarding angiogenesis...
January 11, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29327302/diffuse-idiopathic-skeletal-hyperostosis-is-associated-with-lumbar-spinal-stenosis-requiring-surgery
#4
Kentaro Yamada, Shigenobu Satoh, Hiroshi Hashizume, Noriko Yoshimura, Ryohei Kagotani, Yuyu Ishimoto, Yuichiro Abe, Hiromitsu Toyoda, Hidetomi Terai, Takeshi Masuda, Shigeyuki Muraki, Hiroaki Nakamura, Munehito Yoshida
Factors related to the onset and progression of lumbar spinal stenosis (LSS) have not yet been identified. Diffuse idiopathic skeletal hyperostosis (DISH) increases mechanical loading on the non-fused lumbar levels and may therefore lead to LSS. This cross-sectional study aimed to identify associations between LSS and DISH. This study included 2363 consecutive patients undergoing surgery for LSS and 787 general inhabitants without symptoms of LSS as participants of the population-based cohort study, Research on Osteoarthritis/Osteoporosis Against Disability...
January 11, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29318392/relationship-between-melatonin-and-bone-resorption-rhythms-in-premenopausal-women
#5
Melissa A St Hilaire, Shadab A Rahman, Joshua J Gooley, Paula A Witt-Enderby, Steven W Lockley
Although evidence exists for a daily rhythm in bone metabolism, the contribution of factors such as melatonin levels, the light-dark cycle, and the sleep-wake cycle is difficult to differentiate given their highly correlated time courses. To examine these influences on bone resorption, we collected 48-h sequential urine samples under both ambulatory (8-h sleep:16-h wake) and constant routine (CR) (constant wake, posture, nutrition and dim light) conditions from 20 healthy premenopausal women. Urinary 6-sulphatoxymelatonin (aMT6s; ng/h) and the bone resorption marker amino-terminal cross-linked collagen I telopeptide (NTx; bone collagen equivalents nM/h) were assayed and fit by cosinor models to determine significant 24-h rhythms and acrophase...
January 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29313098/decrease-of-bone-mineral-density-in-japanese-patients-with-non-metastatic-prostate-cancer-treated-with-androgen-deprivation-therapy
#6
Seiichi Kato, Makoto Kawase, Daiki Kato, Takashi Ishida, Masahiro Uno, Yoshinori Fujimoto, Takako Masue, Naruyasu Masue, Takashi Deguchi
The aim of this study was to conduct a cross-sectional survey of investigations related to the bone mineral density (BMD) of both non-metastatic prostate cancer (NMPC) patients who have not yet received androgen deprivation therapy (ADT) and patients receiving prolonged ADT in Japan. Japanese male patients with NMPC who received continuous ADT or who were planning to receive ADT were enrolled in this study. Lumbar spine and femoral neck BMD was measured using dual-energy X-ray absorptiometry (DEXA). To assess patient characteristics, we searched medical records and questionnaires to determine whether they had any factors that could possibly affect BMD...
January 8, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29282553/muscle-strength-is-associated-with-bone-health-independently-of-muscle-mass-in-postmenopausal-women-the-japanese-population-based-osteoporosis-study
#7
Takahiro Tachiki, Katsuyasu Kouda, Namiraa Dongmei, Junko Tamaki, Masayuki Iki, Jun Kitagawa, Naonobu Takahira, Yuho Sato, Etsuko Kajita, Yuki Fujita, Akiko Yura, Sadanobu Kagamimori
There are conflicting reports on whether muscle strength is associated with bone mineral density (BMD) independently of muscle mass. Here, we examined the association between muscle strength and BMD in a representative population of Japanese women. Cross-sectional data from 680 postmenopausal women, who were participants in the 15th-year follow-up survey of the Japanese Population-based Osteoporosis cohort study, were analyzed. Areal BMD (aBMD) at the femoral neck and lumbar spine, whole-body bone mineral density, and appendicular skeletal muscle mass (ASM, kg) were measured by dual-energy X-ray absorptiometry...
December 27, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29280078/increased-risk-of-fractures-in-patients-with-polycystic-ovary-syndrome-a-nationwide-population-based-retrospective-cohort-study
#8
Hsin-Yi Yang, Herng-Sheng Lee, Wan-Ting Huang, Ming-Jer Chen, Solomon Chih-Cheng Chen, Yueh-Han Hsu
Polycystic ovary syndrome (PCOS) is a complex disorder; various features of this disorder may influence bone metabolism and skeletal mass. The contribution of PCOS to lower bone mineral density has been recognized. However, the impact of PCOS on the long-term risks for fractures remains inconclusive. The aim of this study was to determine the risk of overall fracture and fractures at different anatomic sites in patients with PCOS. Using a nationwide health insurance claims database, we included 11,106 subjects, aged 15-80 years, with newly diagnosed PCOS (ICD-9-CM: 254...
December 26, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29280077/effects-of-combined-human-parathyroid-hormone-1-34-and-menaquinone-4-treatment-on-the-interface-of-hydroxyapatite-coated-titanium-implants-in-the-femur-of-osteoporotic-rats
#9
Hang Li, Qiang Zhou, Bing-Li Bai, She-Ji Weng, Zong-Yi Wu, Zhong-Jie Xie, Zhen-Hua Feng, Liang Cheng, Viraj Boodhun, Lei Yang
The objective of this study was to investigate the effects of human parathyroid hormone (1-34) (PTH1-34; PTH) plus menaquinone-4 (vitamin K2; MK) on the osseous integration of hydroxyapatite (HA)-coated implants in osteoporotic rats. Ovariectomized female Sprague-Dawley rats were used for the study. Twelve weeks after bilateral ovariectomy, HA-coated titanium implants were inserted bilaterally in the femoral medullary canal of the remaining 40 ovariectomized rats. All animals were then randomly assigned to four groups: Control, MK, PTH and PTH + MK...
December 26, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29273889/tumor-necrosis-factor-receptor-associated-factor-6-is-required-to-inhibit-foreign-body-giant-cell-formation-and-activate-osteoclasts-under-inflammatory-and-infectious-conditions
#10
Akihito Oya, Eri Katsuyama, Mayu Morita, Yuiko Sato, Tami Kobayashi, Kana Miyamoto, Toru Nishiwaki, Atsushi Funayama, Yoshinari Fujita, Takashi Kobayashi, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Osteoclasts and foreign body giant cells (FBGCs) are derived from common progenitors and share properties such as multi-nucleation capacity induced by cell-cell fusion; however, mechanisms underlying lineage determination between these cells remain unclear. Here we show that, under inflammatory conditions, osteoclasts are stimulated in a manner similar to M1 macrophages, while formation of FBGCs, which exhibit M2-like phenotypes, is inhibited in a manner similar to that seen in M1/M2 macrophage polarization...
December 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29273888/identification-of-pleiotropic-genetic-variants-affecting-osteoporosis-risk-in-a-korean-elderly-cohort
#11
Eun Pyo Hong, Ka Hyun Rhee, Dong Hyun Kim, Ji Wan Park
Pleiotropy has important implications for understanding the genetic basis and risk assessment of osteoporosis. Our aim was to identify pleiotropic genetic variants associated with the development of osteoporosis and predict osteoporosis risk by leveraging pleiotropic variants. We evaluated the effects of 21 conventional risk factors and 185 single-nucleotide polymorphisms (SNPs) in 63 inflammation- and metabolism-related genes on osteoporosis risk in a community-based Korean cohort study of 1025 participants, the Hallym Aging Study...
December 22, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29264750/study-of-the-osteogenesis-effect-of-icariside-ii-and-icaritin-on-canine-bone-marrow-mesenchymal-stem-cells
#12
Guangming Luo, Biao Xu, Weihong Wang, Yong Wu, Ming Li
This study aimed to identify the osteogenesis effect of icariside II (ICSII) and icaritin (ICT) in vitro. Bone marrow mesenchymal stem cells (BMSCs) were treated with ICSII and ICT in order to detect the proliferation and differentiation of BMSCs, the expression of the osteogenesis-related proteins with or without osteogenic medium (OM) and genes, Runt-related transcription factor 2 (Runx-2), osteocalcin (OCN), osteopontin (OPN), osterix, and basic fibroblast growth factor (bFGF), and the phosphorylation levels of mitogen-activated protein kinase (MAPK)...
December 20, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29236162/bisphosphonates-prevent-age-related-weight-loss-in-japanese-postmenopausal-women
#13
Tomohiko Urano, Masataka Shiraki, Tatsuhiko Kuroda, Shiro Tanaka, Fumihiko Urano, Kazuhiro Uenishi, Satoshi Inoue
Decline of body weight with aging is a major risk factor for frailty, osteoporosis and fracture, suggesting that treatment for osteoporosis may affect body composition. Recently, we have shown that 5-year treatment with raloxifene prevented age-related weight loss, suggesting some other drugs for osteoporosis may also prevent a decrease in body weight with aging. The present study aimed to identify the relationship between bisphosphonate treatment and body composition markers. We measured bone mineral density (BMD), body composition, and bone remodeling markers in 551 Japanese postmenopausal women with bisphosphonate treatment, which included risedronate or alendronate treatment (BP-treatment group; N = 193) and without treatment by any osteoporosis drug (no-treatment group; N = 358) for 4-7 years (mean observation periods; 5...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29236161/genetic-analysis-of-adults-heterozygous-for-alpl-mutations
#14
Agnès Taillandier, Christelle Domingues, Annika Dufour, Françoise Debiais, Pascal Guggenbuhl, Christian Roux, Catherine Cormier, Bernard Cortet, Valérie Porquet-Bordes, Fabienne Coury, David Geneviève, Jean Chiesa, Thierry Colin, Elaine Fletcher, Agnès Guichet, Rose-Marie Javier, Michel Laroche, Michael Laurent, Ekkehart Lausch, Bruno LeHeup, Cédric Lukas, Georg Schwabe, Ineke van der Burgt, Christine Muti, Brigitte Simon-Bouy, Etienne Mornet
Hypophosphatasia (HPP) is a rare inherited metabolic bone disease due to a deficiency of the tissue nonspecific alkaline phosphatase isoenzyme (TNSALP) encoded by the ALPL gene. Patients have consistently low serum alkaline phosphatase (AP), so that this parameter is a good hallmark of the disease. Adult HPP is heterogeneous, and some patients present only mild nonpathognomonic symptoms which are also common in the general population such as joint pain, osteomalacia and osteopenia, chondrocalcinosis, arthropathy and musculoskeletal pain...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29234953/involvement-of-microrna-23b-in-tnf-%C3%AE-reduced-bmsc-osteogenic-differentiation-via-targeting-runx2
#15
Lin Deng, Guoli Hu, Lei Jin, Chenglong Wang, Hongwen Niu
Elucidation of the molecular mechanism governing bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation is of great importance for improving the treatment of osteoporosis. TNF-α is a well-known inhibitory factor during osteogenic differentiation of BMSCs. In our experiment, we consistently observed that TNF-α significantly inhibited BMSC osteogenic differentiation, which was partially rescued by BAY 11-7082 (NF-κB inhibitor). In this study, we examined the potential roles of microRNAs (miRNAs) involved in TNF-α-mediated reduction of BMSC osteogenesis...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29234952/increased-calcium-uptake-and-improved-trabecular-bone-properties-in-intestinal-alkaline-phosphatase-knockout-mice
#16
Lucas R Brun, M Lombarte, S Roma, F Perez, J L Millán, A Rigalli
Previous studies have demonstrated a negative correlation between intestinal alkaline phosphatase (IAP) activity and calcium (Ca) absorption in the gut, as IAP acts as a protective mechanism inhibiting high Ca entry into enterocytes, preventing Ca overload. Here we evaluated Ca absorption and bone properties in knockout mice (KO) completely devoid of duodenal IAP (Akp3 -/- mice). Female C57BL/6 control mice (WT, n = 7) and KO mice (n = 10) were used to determine Ca absorption in vivo and by in situ isolated duodenal loops followed by histomorphometric analysis of duodenal villi and crypts...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29234951/zinc-finger-transcription-factor-odd-skipped-related-1-regulates-cranial-bone-formation
#17
Shinji Kawai, Masashi Yamauchi, Atsuo Amano
Knowledge of the molecular mechanisms of bone formation has been advanced by novel findings related to genetic control. Odd-skipped related 1 (Osr1) is known to play important roles in embryonic, heart, and urogenital development. To elucidate the in vivo function of Osr1 in bone formation, we generated transgenic mice overexpressing full-length Osr1 under control of its 2.8-kb promoter, which were smaller than their wild-type littermates. Notably, abnormalities in the skull of Osr1 transgenic mice were revealed by analysis of X-ray, skeletal preparation, and morphological findings, including round skull and cranial dysraphism...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29134283/investigation-of-the-relation-between-bone-mass-density-and-serum-preptin-levels-in-pre-and-postmenopausal-women
#18
Saeed Nazari Soltan Aahmad, Sajjad Nourollahi, Faranak Kazerouni, Nahid Kianmehr, Hamed Hajipour, Davoud Sanajou, Vahid Hosseini
Preptin is a peptide hormone co-secreted with insulin and amylin from pancreatic β cells. It has been demonstrated to have osteogenic effects both in vitro and in vivo. In the present study, serum preptin levels were measured in pre- and postmenopausal women with similar body mass indexes (BMIs) to elucidate its link with bone mineral density (BMD). Sixty women (30 premenopausal and 30 postmenopausal) with low bone mineral density were studied. The BMD scores, serum preptin levels and serum estradiol levels were measured...
November 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29128970/cord-serum%C3%A2-25-hydroxyvitamin-d-is-not-associated-with-cranial-anthropometrics-in-infants-up-to-6%C3%A2-months-of-age-an-odense-child-cohort-study
#19
Sissil Egge, Nikolas Christensen, Sine Lykkedegn, Tina Kold Jensen, Henrik Thybo Christesen
Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy s-25(OH)D and anterior fontanel area (n = 765), head circumference (HC, n = 1776) and head shape (n = 1527) were investigated along with other factors. Age was corrected for preterm birth...
November 11, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29124437/optimal-vitamin-d-intake-for-preventing-serum-25-hydroxyvitamin-d-insufficiency-in-young-japanese-women
#20
Hiroaki Ohta, Tatsuhiko Kuroda, Naoko Tsugawa, Yoshiko Onoe, Toshio Okano, Masataka Shiraki
Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R (2) = 0...
November 9, 2017: Journal of Bone and Mineral Metabolism
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