journal
MENU ▼
Read by QxMD icon Read
search

Learning & Memory

journal
https://www.readbyqxmd.com/read/29038223/modulation-of-target-recollection-and-recollection-rejection-networks-due-to-retrieval-facilitation-and-interference
#1
Caitlin R Bowman, Shalome L Sine, Nancy A Dennis
To better understand neural recollection processing, we induced interference in target recollection by presenting related lures before their respective targets and facilitated recollection rejection of lures by presenting targets before their related lures. Target recollection following interference recruited visual and prefrontal cortices, showing that these regions support recollection when related information has disrupted target representations. Recollection rejection following target presentation recruited angular gyrus, indicating that this region supports recollection rejection when target representations are strong and highly accessible...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038222/post-training-reversible-disconnection-of-the-ventral-hippocampal-basolateral-amygdaloid-circuits-impairs-consolidation-of-inhibitory-avoidance-memory-in-rats
#2
Gong-Wu Wang, Jian Liu, Xiao-Qin Wang
The ventral hippocampus (VH) and the basolateral amygdala (BLA) are both crucial in inhibitory avoidance (IA) memory. However, the exact role of the VH-BLA circuit in IA memory consolidation is unclear. This study investigated the effect of post-training reversible disconnection of the VH-BLA circuit in IA memory consolidation. Male Wistar rats with implanted guide cannulae were trained with a one-trial IA task, then received immediate intracerebral injections of muscimol or saline, and were tested 24 h later...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038221/prazosin-during-threat-discrimination-boosts-memory-of-the-safe-stimulus
#3
Philipp Homan, Qi Lin, James W Murrough, Laili Soleimani, Dominik R Bach, Roger L Clem, Daniela Schiller
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that prazosin during threat acquisition may have influenced encoding or consolidation of safety processing in particular, subsequently leading to enhanced discrimination between the safe and threatening stimuli...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038220/context-memory-formation-requires-activity-dependent-protein-degradation-in-the-hippocampus
#4
Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, Fred J Helmstetter
Numerous studies have indicated that the consolidation of contextual fear memories supported by an aversive outcome like footshock requires de novo protein synthesis as well as protein degradation mediated by the ubiquitin-proteasome system (UPS). Context memory formed in the absence of an aversive stimulus by simple exposure to a novel environment requires de novo protein synthesis in both the dorsal (dHPC) and ventral (vHPC) hippocampus. However, the role of UPS-mediated protein degradation in the consolidation of context memory in the absence of a strong aversive stimulus has not been investigated...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038219/the-l-type-voltage-gated-calcium-channel-cav1-2-mediates-fear-extinction-and-modulates-synaptic-tone-in-the-lateral-amygdala
#5
Stephanie J Temme, Geoffrey G Murphy
L-type voltage-gated calcium channels (LVGCCs) have been implicated in both the formation and the reduction of fear through Pavlovian fear conditioning and extinction. Despite the implication of LVGCCs in fear learning and extinction, studies of the individual LVGCC subtypes, CaV1.2 and CaV1.3, using transgenic mice have failed to find a role of either subtype in fear extinction. This discontinuity between the pharmacological studies of LVGCCs and the studies investigating individual subtype contributions could be due to the limited neuronal deletion pattern of the CaV1...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038218/experiential-learning-in-rodents-past-experience-enables-rapid-learning-and-localized-encoding-in-hippocampus
#6
Conor D Cox, Linda C Palmer, Danielle T Pham, Brian H Trieu, Christine M Gall, Gary Lynch
Humans routinely use past experience with complexity to deal with novel, challenging circumstances. This fundamental aspect of real-world behavior has received surprisingly little attention in animal studies, and the underlying brain mechanisms are unknown. The present experiments tested for transfer from past experience in rats and then used quantitative imaging to localize synaptic modifications in hippocampus. Six daily exposures to an enriched environment (EE) caused a marked enhancement of short- and long-term memory encoded during a 30-min session in a different and complex environment relative to rats given extensive handling or access to running wheels...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/29038217/hippocampal-area-ca1-and-remote-memory-in-rats
#7
Amber C Ocampo, Larry R Squire, Robert E Clark
Hippocampal lesions often produce temporally graded retrograde amnesia (TGRA), whereby recent memory is impaired more than remote memory. This finding has provided support for the process of systems consolidation. However, temporally graded memory impairment has not been observed with the watermaze task, and the findings have been inconsistent with context fear conditioning. One possibility is that large hippocampal lesions indirectly disrupt (by retrograde degeneration) the function of areas that project to the hippocampus that are important for task performance or thought to be important for storing consolidated memories...
November 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916631/experience-during-early-adulthood-shapes-the-learning-capacities-and-the-number-of-synaptic-boutons-in-the-mushroom-bodies-of-honey-bees-apis-mellifera
#8
Amélie Cabirol, Rufus Brooks, Claudia Groh, Andrew B Barron, Jean-Marc Devaud
The honey bee mushroom bodies (MBs) are brain centers required for specific learning tasks. Here, we show that environmental conditions experienced as young adults affect the maturation of MB neuropil and performance in a MB-dependent learning task. Specifically, olfactory reversal learning was selectively impaired following early exposure to an impoverished environment lacking some of the sensory and social interactions present in the hive. In parallel, the overall number of synaptic boutons increased within the MB olfactory neuropil, whose volume remained unaffected...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916630/false-memories-for-shape-activate-the-lateral-occipital-complex
#9
Jessica M Karanian, Scott D Slotnick
Previous functional magnetic resonance imaging evidence has shown that false memories arise from higher-level conscious processing regions rather than lower-level sensory processing regions. In the present study, we assessed whether the lateral occipital complex (LOC)-a lower-level conscious shape processing region-was associated with false memories for shape. During encoding, participants viewed intact or scrambled colored abstract shapes. During retrieval, colored disks were presented and participants indicated whether the corresponding item was previously "intact" or "scrambled...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916629/histone-deacetylase-inhibition-induces-odor-preference-memory-extension-and-maintains-enhanced-ampa-receptor-expression-in-the-rat-pup-model
#10
Sriya Bhattacharya, Bandhan Mukherjee, Jules J E Doré, Qi Yuan, Carolyn W Harley, John H McLean
Histone deacetylase (HDAC) plays a role in synaptic plasticity and long-term memory formation. We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced GluA1 receptor levels that have been hypothesized to support memory. We used an early odor preference learning model in neonate rat pups that normally produces only 24-h memory to test behavior and examine receptor protein expression. Our behavioral studies showed that intrabulbar infusion of TSA, prior to pairing of the conditioned stimulus (peppermint odor) with the unconditioned stimulus (tactile stimulation), prolonged 24-h odor preference memory for at least 9 d...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916628/the-impact-of-threat-of-shock-induced-anxiety-on-memory-encoding-and-retrieval
#11
Sorcha Bolton, Oliver J Robinson
Anxiety disorders are the most common mental health disorders, and daily transient feelings of anxiety (or "stress") are ubiquitous. However, the precise impact of both transient and pathological anxiety on higher-order cognitive functions, including short- and long-term memory, is poorly understood. A clearer understanding of the anxiety-memory relationship is important as one of the core symptoms of anxiety, most prominently in post-traumatic stress disorder (PTSD), is intrusive reexperiencing of traumatic events in the form of vivid memories...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916627/interactions-between-medial-prefrontal-cortex-and-dorsomedial-striatum-are-necessary-for-odor-span-capacity-in-rats-role-of-glun2b-containing-nmda-receptors
#12
Don A Davies, Quentin Greba, Jantz C Selk, Jillian K Catton, Landon D Baillie, Sean J Mulligan, John G Howland
Working memory is involved in the maintenance and manipulation of information essential for complex cognition. While the neural substrates underlying working memory capacity have been studied in humans, considerably less is known about the circuitry mediating working memory capacity in rodents. Therefore, the present experiments tested the involvement of medial prefrontal cortex (mPFC) and dorsal striatum (STR) in the odor span task (OST), a task proposed to assay working memory capacity in rodents. Initially, Long Evans rats were trained to dig in scented sand for food following a serial delayed nonmatching-to-sample rule...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916626/contextual-fear-conditioning-in-zebrafish
#13
Justin W Kenney, Ian C Scott, Sheena A Josselyn, Paul W Frankland
Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using an electric shock as the aversive stimulus. We find that contextual fear conditioning is modulated by shock intensity, prevented by an established amnestic agent (MK-801), lasts at least 14 d, and exhibits extinction...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28916625/transcriptional-correlates-of-memory-maintenance-following-long-term-sensitization-of-aplysia-californica
#14
Catherine Conte, Samantha Herdegen, Saman Kamal, Jency Patel, Ushma Patel, Leticia Perez, Marissa Rivota, Robert J Calin-Jageman, Irina E Calin-Jageman
We characterized the transcriptional response accompanying maintenance of long-term sensitization (LTS) memory in the pleural ganglia of Aplysia californica using microarray (N = 8) and qPCR (N = 11 additional samples). We found that 24 h after memory induction there is strong regulation of 1198 transcripts (748 up and 450 down) in a pattern that is almost completely distinct from what is observed during memory encoding (1 h after training). There is widespread up-regulation of transcripts related to all levels of protein production, from transcription (e...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/29054891/special-issue-on-the-effect-of-fear-and-stress-on-memory
#15
EDITORIAL
Susan Cushman, John H Byrne
No abstract text is available yet for this article.
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814475/developmental-pathway-genes-and-neural-plasticity-underlying-emotional-learning-and-stress-related-disorders
#16
Marissa E Maheu, Kerry J Ressler
The manipulation of neural plasticity as a means of intervening in the onset and progression of stress-related disorders retains its appeal for many researchers, despite our limited success in translating such interventions from the laboratory to the clinic. Given the challenges of identifying individual genetic variants that confer increased risk for illnesses like depression and post-traumatic stress disorder, some have turned their attention instead to focusing on so-called "master regulators" of plasticity that may provide a means of controlling these potentially impaired processes in psychiatric illnesses...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814474/role-of-the-bed-nucleus-of-the-stria-terminalis-in-aversive-learning-and-memory
#17
Travis D Goode, Stephen Maren
Surviving threats in the environment requires brain circuits for detecting (or anticipating) danger and for coordinating appropriate defensive responses (e.g., increased cardiac output, stress hormone release, and freezing behavior). The bed nucleus of the stria terminalis (BNST) is a critical interface between the "affective forebrain"-including the amygdala, ventral hippocampus, and medial prefrontal cortex-and the hypothalamic and brainstem areas that have been implicated in neuroendocrine, autonomic, and behavioral responses to actual or anticipated threats...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814473/breaking-boundaries-optimizing-reconsolidation-based-interventions-for-strong-and-old-memories
#18
James W B Elsey, Merel Kindt
Recent research has demonstrated that consolidated memories can enter a temporary labile state after reactivation, requiring restabilization in order to persist. This process, known as reconsolidation, potentially allows for the modification and disruption of memory. Much interest in reconsolidation stems from the possibility that maladaptive memory traces-a core feature of several psychiatric conditions-could be tackled by disrupting their reconsolidation. However, research has indicated a range of supposed boundary conditions on the induction of reconsolidation...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814472/neurobiology-of-fear-and-specific-phobias
#19
René Garcia
Fear, which can be expressed innately or after conditioning, is triggered when a danger or a stimulus predicting immediate danger is perceived. Its role is to prepare the body to face this danger. However, dysfunction in fear processing can lead to psychiatric disorders in which fear outweighs the danger or possibility of harm. Although recognized as highly debilitating, pathological fear remains insufficiently treated, indicating the importance of research on fear processing. The neurobiological basis of normal and pathological fear reactions is reviewed in this article...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814471/novelty-and-fear-conditioning-induced-gene-expression-in-high-and-low-states-of-anxiety
#20
Melanie P Donley, Jeffrey B Rosen
Emotional states influence how stimuli are interpreted. High anxiety states in humans lead to more negative, threatening interpretations of novel information, typically accompanied by activation of the amygdala. We developed a handling protocol that induces long-lasting high and low anxiety-like states in rats to explore the role of state anxiety on brain activation during exposure to a novel environment and fear conditioning. In situ hybridization of the inducible transcription factor Egr-1 found increased gene expression in the lateral nucleus of the amygdala (LA) following exposure to a novel environment and contextual fear conditioning in high anxiety-like rats...
September 2017: Learning & Memory
journal
journal
32021
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"